SHIMIZU HIROYUKI 清水博之

… Alternative Names

清水博之シミズヒロユキ

SHIMIZU Hiroyuki 清水博之

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Researcher Number	90270644
Other IDs	https://orcid.org/0000-0002-2987-2377
External Links
Affiliation (Current)	2025: 国立健康危機管理研究機構, ウイルス第二部, 主任研究員
Affiliation (based on the past Project Information) *help	2021 – 2022: 国立感染症研究所, ウイルス第二部, 主任研究官 2016 – 2020: 国立感染症研究所, ウイルス第二部, 室長 2019: 国立感染症研究所, ウイルス第二部, 主任研究官 2014 – 2016: 国立感染症研究所, その他部局等, その他 2014: 国立感染症研究所, ウイルス第2部, 室長 … More 2010 – 2014: 国立感染症研究所, ウイルス第二部, 室長 2013: 国立感染症研究所, その他部局等, 室長 2003: NATIONAL INSTITUTE OF INFECTIOUS DISEASES, DEPARTMENT OF VIROLOGY II, CHIEF, ウイルス第2部・室長, 厚生労働技官 2001 – 2003: 国立感染症研究所, ウイルス第二部, 室長 2000: 国立感染症研究所, ウイルス二部, 主任研究官 2000: Institute of Infectious Diseases Senior Researcher, ウイルス第2部, 厚生技官 1999: 国立感染症研究所, ウイルス第二部, 厚生技官 1997: National Institute of Infectious Diseases, Dept.of Virology II, ウイルス第二部, 研究員 1996: 国立予防衛生研究所, ウイルス第二部, 研究員 Less
Review Section/Research Field	Principal Investigator Virology / Virology / Biological pharmacy Except Principal Investigator Virology / Virology / Basic Section 52050:Embryonic medicine and pediatrics-related / Clinical oncology
Keywords	Principal Investigator 手足口病 / エンテロウイルス71 / エンテロウイルス / 病原性 / PSGL-1 / 受容体 / 動物モデル / 感染症 / ウイルス / カニクイザル … More / レセプター / 感染モデル / エンテロウイルスA71 / MOLECULAR EPIDEMIOLOGY / CNS INFECTION / ENCEPHALITIS / HAND, FOOT AND MOUTH DISEASE / ENTEROVIRUS71 / ENTEROVIRUS / エンテロウイルス感染症 / マレーシア:中国:タイ:ベトナム / 国際情報交換 / 分子疫学 / 中枢神経感染 / 脳炎 / 分子進化 / 感染動物モデル / 抗ウイルス剤 / ベンズイミダゾール / NTPase / 2C蛋白質 / ポリオウイルス … More Except Principal Investigator RNA belicase / ATPase / NS3 protein / JEV / 動物モデル / ウイルス / 感染症 / 神経病原性 / 麻痺 / エンテロウイルス / 急性弛緩性麻痺 / 弛緩性麻痺 / エンテロウイルスD68 / RNA helicase / nucleotide sequence / oral polio vaccine / wild strain / polioeradication program / poliomyelitis / トランスジェニックマウス / リコンビナントウイルス / ワクチン / ポリオウイルス / 塩基配列 / ポリオワクチン / 野生株 / ポリオ根絶計画 / ポリオ / 病原性 / 病理学 / 脳神経疾患 / 神経毒力 / ウイルス受容体 / マウス感染モデル / エンテロウイルス７１ / CVB3精製 / miR-217 / miR-1 / 遺伝子改変CVB3 / miRNA相補配列挿入CVB3 / 密度勾配遠心法 / コクサッキーウイルス(CV)B3 / microRNA / 顆粒球マクロファージコロニー刺激因子 / GMP / コクサッキーウイルス / 腫瘍溶解性ウイルス療法 / ウイルス製造 / 担癌マウスモデル / GMP準拠 / 一般毒性試 / 医薬品医療機器総合機構 / 腫瘍溶解ウイルス / GM-CSF / 一般毒性試験 / ウイルス製剤製造 / 顆粒球マクロファージ刺激因子 / miRNA / コクサッキーウイルスB群3型 / 腫瘍溶解性ウイルス Less

Study on pathogenesis of flaccid paralysis caused by enterovirus D68 using animal models
- Principal Investigator
  
  Nagata Noriyo
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Institute of Infectious Diseases
The involvement of amino acid mutations of the capsid ptoteins of enterovirus A71 in viral genetic diversity and neuropathogenesisPrincipal Investigator
- Principal Investigator
  
  Shimizu Hiroyuki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases
Changes in receptor specificity and pathogenesis associated with mutations of capsid amino acids of enterovirus 71 in host adaptationPrincipal Investigator
- Principal Investigator
  
  SHIMIZU HIROYUKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases
Clinical development of the novel oncolytic coxsackievirus B3 targeting malignant tumors
- Principal Investigator
  
  TANI Kenzaburo
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Clinical oncology
- Research Institution
  Kyushu University
Molecular basis of enterovirus 71 neuropathogenicity
- Principal Investigator
  
  KOIKE Satoshi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Pathogenesis of Saffold virus infection in animal models
- Principal Investigator
  
  NAGATA Noriyo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases
The molecular basis of PSGL-1-dependent viral replication and pathogenesis in enterovirus 71 infectionPrincipal Investigator
- Principal Investigator
  
  SHIMIZU HIROYUKI
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases
VIROLOGICAL AND PATHOLOGICAL ANALYSIS OF ENTEROVIRUS 71 ENCEPHALITIS IN THE WESTERN PACIFIC REGIONPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Hiroyuki
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  NATIONAL INSTITUTE OF INFECTIOUS DISEASES
Study on the RNA Helicase Activity of the Flavivirus NS3 Proteins
- Principal Investigator
  
  IGARASHI Akira
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Institute of Tropical Medicine, Nagasaki University
ポリオウイルス2C蛋白質機能の阻害剤を用いた解析Principal Investigator
- Principal Investigator
  
  清水博之
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  国立予防衛生研究所
Genetic analysis of wild polioviruses and its ecology
- Principal Investigator
  
  MIYAMURA Tatsuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Virology
- Research Institution
  National Institute of Infectious Diseases

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] ウイルス検査法2018
- Author(s)
  清水博之
- Total Pages
  382
- Publisher
  日本臨床ウイルス学会
- ISBN
- Data Source
  KAKENHI-PROJECT-16H05200
[Book] グローバル時代のウイルス感染症2018
- Author(s)
  清水博之
- Total Pages
  279
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-16H05200
[Book] ワクチン― 基礎から臨床まで ―2018
- Author(s)
  中野貴司、清水博之
- Total Pages
  350
- Publisher
  日本ワクチン学会
- Data Source
  KAKENHI-PROJECT-16H05200
[Book] 感染症予防必携 (第３版)　「急性灰白髄炎」の項を担当2015
- Author(s)
  清水博之
- Total Pages
  634
- Publisher
  日本公衆衛生協会
- Data Source
  KAKENHI-PROJECT-25293111
[Book] まるわかりワクチン Q&A　Q25およびQ26を担当2015
- Author(s)
  清水博之
- Total Pages
  407
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-25293111
[Book] 臨床医のための呼吸器・消化管ウイルス感染症消化器ウイルス篇　エンテロウイルス-ポリオウイルスおよび非ポリオエンテロウイルス」の項を分担執筆2014
- Author(s)
  清水博之
- Total Pages
  135
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-25293111
[Journal Article] エンテロウイルス感染による急性弛緩性麻痺の病理2020
- Author(s)
  永田典代、長谷川秀樹、清水博之、斎藤博之
- Journal Title
  
  病原微生物検出情報
  
  Volume: 41 Pages: 25-27
- Open Access
- Data Source
  KAKENHI-PROJECT-19H03626
[Journal Article] Coxsackieviruses A6 and A16 associated with hand, foot, and mouth disease in Vietnam, 2008?2017: Essential information for rational vaccine design2020
- Author(s)
  Hoa-Tran Thi Nguyen、Dao Anh Thi Hai、Nguyen Anh The、Kataoka Chikako、Takemura Taichiro、Pham Chau Ha、Vu Hung Manh、Hong Ta Thi Thu、Ha Nguyen Thi Viet、Duong Tran Nhu、Thanh Nguyen Thi Hien、Shimizu Hiroyuki
- Journal Title
  
  Vaccine
  
  Volume: 38 Issue: 52 Pages: 8273-8285
- DOI
  10.1016/j.vaccine.2020.11.031
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03626
[Journal Article] Neuropathology in Neonatal Mice After Experimental Coxsackievirus B2 Infection Using a Prototype Strain, Ohio-12019
- Author(s)
  Ushioda Waka、Kotani Osamu、Kawachi Kengo、Iwata-Yoshikawa Naoko、Suzuki Tadaki、Hasegawa Hideki、Shimizu Hiroyuki、Takahashi Kimimasa、Nagata Noriyo
- Journal Title
  
  Journal of Neuropathology & Experimental Neurology
  
  Volume: 79 Issue: 2 Pages: 209-225
- DOI
  10.1093/jnen/nlz124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03626
[Journal Article] Serial MRI findings of acute flaccid myelitis during an outbreak of enterovirus D68 infection in Japan2019
- Author(s)
  Okumura Akihisa、Mori Harushi、Fee Chong Pin、Kira Ryutaro、Torisu Hiroyuki、Yasumoto Sawa、Shimizu Hiroyuki、Fujimoto Tsuguto、Tanaka-Taya Keiko
- Journal Title
  
  Brain and Development
  
  Volume: 41 Issue: 5 Pages: 443-451
- DOI
  10.1016/j.braindev.2018.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-18K07890, KAKENHI-PROJECT-19H03626
[Journal Article] Molecular characterization of enterovirus-A71 in children with acute flaccid paralysis in the Philippines2019
- Author(s)
  Apostol Lea Necitas、Shimizu Hiroyuki、Suzuki Akira、Umami Rifqiyah Nur、Jiao Maria Melissa Ann、Tandoc Amado、Saito Mariko、Lupisan Socorro、Oshitani Hitoshi
- Journal Title
  
  BMC Infectious Diseases
  
  Volume: 19 Issue: 1
- DOI
  10.1186/s12879-019-3955-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Journal Article] Nationwide Survey of Pediatric Inpatients With Hand, Foot, and Mouth Disease, Herpangina, and Associated Complications During an Epidemic Period in Japan: Estimated Number of Hospitalized Patients and Factors Associated With Severe Cases2019
- Author(s)
  Takechi Maria、Fukushima Wakaba、Nakano Takashi、Inui Miki、Ohfuji Satoko、Kase Tetsuo、Ito Kazuya、Kondo Kyoko、Maeda Akiko、Shimizu Hiroyuki、Hirota Yoshio
- Journal Title
  
  Journal of Epidemiology
  
  Volume: 29 Issue: 9 Pages: 354-362
- DOI
  10.2188/jea.JE20180060
- NAID
  130007703035
- ISSN
  0917-5040, 1349-9092
- Year and Date
  2019-09-05
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05200
[Journal Article] Enterovirus D68 respiratory infection in a children's hospital in Japan in 20152019
- Author(s)
  Funakoshi Yu、Ito Kenta、Morino Saeko、Kinoshita Kazue、Morikawa Yoshihiko、Kono Tatsuo、Doan Yen Hai、Shimizu Hiroyuki、Hanaoka Nozomu、Konagaya Masami、Fujimoto Tsuguto、Suzuki Ai、Chiba Takashi、Akiba Tetsuya、Tomaru Yasuhiro、Watanabe Ken、Shimizu Norio、Horikoshi Yuho
- Journal Title
  
  Pediatrics International
  
  Volume: 61 Issue: 8 Pages: 768-776
- DOI
  10.1111/ped.13903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03626
[Journal Article] Notes from the Field: Circulating Vaccine-Derived Poliovirus Type 1 and Outbreak Response ? Papua New Guinea, 20182019
- Author(s)
  Bauri Mathias、Wilkinson Amanda L.、Ropa Berry、Feldon Keith、Snider Cynthia J.、Anand Abhijeet、Tallis Graham、Boualam Liliane、Grabovac Varja、Avagyan Tigran、Reza Mohammad S.、Mekonnen Dessie、Zhang Zaixing、Thorley Bruce R.、Shimizu Hiroyuki、Apostol Lea Necitas G.、Takashima Yoshihiro
- Journal Title
  
  MMWR. Morbidity and Mortality Weekly Report
  
  Volume: 68 Issue: 5 Pages: 119-120
- DOI
  10.15585/mmwr.mm6805a6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Journal Article] Polio vaccination coverage and seroprevalence of poliovirus antibodies after the introduction of inactivated poliovirus vaccines for routine immunization in Japan2019
- Author(s)
  Satoh Hiroshi、Tanaka-Taya Keiko、Shimizu Hiroyuki、Goto Akiko、Tanaka Shizuka、Nakano Tsuyoshi、Hotta Chiemi、Okazaki Terue、Itamochi Masae、Ito Miyabi、Okamoto-Nakagawa Reiko、Yamashita Yasutaka、Arai Satoru、Okuno Hideo、Morino Saeko、Oishi Kazunori
- Journal Title
  
  Vaccine
  
  Volume: 37 Issue: 14 Pages: 1964-1971
- DOI
  10.1016/j.vaccine.2019.02.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05200
[Journal Article] Detection and genetic characterization of enterovirus strains circulating among children with acute gastroenteritis in Japan during 2014?20162018
- Author(s)
  Ngan Thi Kim Pham、Aksara Thongprachum、Quang Duy Trinh、Shoko Okitsu、Shihoko Komine-Aizawa、Hiroyuki Shimizu、Satoshi Hayakawa、Hiroshi Ushijima
- Journal Title
  
  Infection, Genetics and Evolution
  
  Volume: 61 Pages: 16-19
- DOI
  10.1016/j.meegid.2018.03.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11160, KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-16H05360
[Journal Article] Equine-like G3 rotavirus strains as predominant strains among children in Indonesia in 2015?20162018
- Author(s)
  Utsumi Takako、Wahyuni Rury Mega、Doan Yen Hai、Dinana Zayyin、Soegijanto Soegeng、Fujii Yoshiki、Juniastuti、Yamani Laura Navika、Matsui Chieko、Deng Lin、Abe Takayuki、Soetjipto、Lusida Maria Inge、Ishii Koji、Shimizu Hiroyuki、Katayama Kazuhiko、Shoji Ikuo
- Journal Title
  
  Infection, Genetics and Evolution
  
  Volume: 61 Pages: 224-228
- DOI
  10.1016/j.meegid.2018.03.027
- NAID
  120006541938
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-16K08825
[Journal Article] A novel combination therapy for human oxaliplatin-resistant colorectal cancer using oxaliplatin and coxsackievirus A11.2018
- Author(s)
  Wang, B., Ogata, H., Takishima, Y., Miyamoto, S., Inoue, H., Kuroda, M., Yamada, K., Hijikata, Y., Murahashi, M., Shimizu, H., Okazaki, T., Nakanishi, Y., Tani, K.
- Journal Title
  
  Anticancer Res.
  
  Volume: 38 Issue: 11 Pages: 6121-6126
- DOI
  10.21873/anticanres.12963
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01547, KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-16K19181, KAKENHI-PROJECT-17K09464
[Journal Article] VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection2018
- Author(s)
  Fujii Ken、Sudaka Yui、Takashino Ayako、Kobayashi Kyousuke、Kataoka Chikako、Suzuki Tadaki、Iwata-Yoshikawa Naoko、Kotani Osamu、Ami Yasushi、Shimizu Hiroyuki、Nagata Noriyo、Mizuta Katsumi、Matsuzaki Yoko、Koike Satoshi
- Journal Title
  
  Journal of Virology
  
  Volume: 92 Issue: 15 Pages: 1-17
- DOI
  10.1128/jvi.00682-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-18H02667, KAKENHI-PROJECT-15K08511
[Journal Article] VP1 amino acid residue 145 of enterovirus 71 is a key residue for its receptor attachment and resistance to neutralizing antibody during cynomolgus monkey infection2018
- Author(s)
  Fujii　K, Sudaka Y, Takashino A, Kobayashi K, Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O, Ami Y, Shimizu H, Nagata N, Mizuta K, Matsuzaki Y, Koike S.
- Journal Title
  
  J Virol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05200
[Journal Article] Detection of nineteen enteric viruses in raw sewage in Japan2018
- Author(s)
  Thongprachum Aksara、Fujimoto Tsuguto、Takanashi Sayaka、Saito Hiroyuki、Okitsu Shoko、Shimizu Hiroyuki、Khamrin Pattara、Maneekarn Niwat、Hayakawa Satoshi、Ushijima Hiroshi
- Journal Title
  
  Infection, Genetics and Evolution
  
  Volume: 63 Pages: 17-23
- DOI
  10.1016/j.meegid.2018.05.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-16H05360
[Journal Article] Acute Flaccid Myelitis Collaborative Study I. Clinical Features of Acute Flaccid Myelitis Temporally Associated With an Enterovirus D68 Outbreak: Results of a Nationwide Survey of Acute Flaccid Paralysis in Japan, August-December 20152018
- Author(s)
  Chong PF, Kira R, Mori H, Okumura A, Torisu H, Yasumoto S, Shimizu H, Fujimoto T, Hanaoka N, Kusunoki S, Takahashi T, Oishi K, Tanaka-Taya K
- Journal Title
  
  Clin Infect Dis
  
  Volume: 66 Issue: 5 Pages: 653-664
- DOI
  10.1093/cid/cix860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-18K07890
[Journal Article] Epidemic dynamics, interactions and predictability of enteroviruses associated with hand, foot and mouth disease in Japan2018
- Author(s)
  Takahashi Saki、Metcalf C. Jessica E.、Arima Yuzo、Fujimoto Tsuguto、Shimizu Hiroyuki、Rogier van Doorn H.、Le Van Tan、Chan Yoke-Fun、Farrar Jeremy J.、Oishi Kazunori、Grenfell Bryan T.
- Journal Title
  
  Journal of The Royal Society Interface
  
  Volume: 15 Issue: 146 Pages: 20180507-20180507
- DOI
  10.1098/rsif.2018.0507
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Journal Article] Multiplex RT-PCR for rapid detection of viruses commonly causing diarrhea in pediatric patients2017
- Author(s)
  Thongprachum A, Khamrin P, Thi Kim Pham N, Takanashi S, Okitsu S, Shimizu H, Maneekarn N, Hayakawa S, Ushijima H
- Journal Title
  
  J Med Virol
  
  Volume: 89 Issue: 5 Pages: 818-824
- DOI
  10.1002/jmv.24711
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-16H05360, KAKENHI-PROJECT-26860434, KAKENHI-PROJECT-17H04341
[Journal Article] エンテロウイルス71ワクチン開発の現状2016
- Author(s)
  清水博之
- Journal Title
  
  小児科
  
  Volume: 57 Pages: 929-936
- Data Source
  KAKENHI-PROJECT-16H05200
[Journal Article] Intracerebral inoculation of mouse-passaged Saffold virus type 3 affects cerebellar development in neonatal mice.2016
- Author(s)
  Kotani O, Suzuki T, Yokoyama M, Iwata-Yoshikawa N, Nakajima N, Sato H, Hasegawa H, Taguchi F, Shimizu H, Nagata N.
- Journal Title
  
  J Virol
  
  Volume: pii: JVI. Issue: 21 Pages: 00864-16
- DOI
  10.1128/jvi.00864-16
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860307, KAKENHI-PROJECT-15K08511, KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-16H05200
[Journal Article] Human rhinovirus infections in hospitalized children: clinical, epidemiological and virological features.2016
- Author(s)
  Tran DN, Trinh QD, Pham NT, Pham TM, Ha MT, Nguyen TQ, Okitsu S, Shimizu H, Hayakawa S, Mizuguchi M, Ushijima H.
- Journal Title
  
  Epidemiol Infect.
  
  Volume: 144 Issue: 2 Pages: 346-54
- DOI
  10.1017/s0950268815000953
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-14F03406, KAKENHI-PROJECT-25460791, KAKENHI-PROJECT-24390266, KAKENHI-PROJECT-25293111
[Journal Article] Neuropathogenicity of Two Saffold Virus Type 3 Isolates in Mouse Models.2016
- Author(s)
  Kotani O, Naeem A, Suzuki T, Iwata-Yoshikawa N, Sato Y, Nakajima N, Hosomi T, Tsukagoshi H, Kozawa K, Hasegawa H, Taguchi F, Shimizu H, Nagata N.
- Journal Title
  
  PLOS One
  
  Volume: 11 Issue: 2 Pages: 1-29
- DOI
  10.1371/journal.pone.0148184
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08511, KAKENHI-PROJECT-25450431, KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-26860307
[Journal Article] Development and introduction of inactivated poliovirus vaccines derived from Sabin strains in Japan2016
- Author(s)
  Shimizu H
- Journal Title
  
  Vaccine
  
  Volume: 34 Issue: 16 Pages: 1975-1985
- DOI
  10.1016/j.vaccine.2014.11.015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-16H05200
[Journal Article] Adult Case of Acute Flaccid Paralysis with Enterovirus D68 Detected in the CSF.2016
- Author(s)
  Kimura K, Fukushima T, Katada N, Shimizu H, Nakamura T, Fujimoto T, Hanaoka N, Tanaka-Taya K, Makino K
- Journal Title
  
  Neurology: Clinical Practice
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05200
[Journal Article] Cosavirus (family Picornaviridae) in pigs in Thailand and Japan2016
- Author(s)
  Okitsu S, Khamrin P, Hanaoka N, Thongprachum A, Takanashi S, Fujimoto T, Mizuguchi M, Shimizu H, Hayakawa S, Maneekarn N, Ushijima H
- Journal Title
  
  Arch Virol
  
  Volume: 161 Issue: 1 Pages: 159-163
- DOI
  10.1007/s00705-015-2637-2
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460791, KAKENHI-PROJECT-24390266, KAKENHI-PROJECT-24390382, KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-15F15117, KAKENHI-PROJECT-26860434
[Journal Article] The suramin derivative NF449 interacts with the 5-fold vertex of the enterovirus A71 capsid to prevent virus attachment to PSGL-1 and heparan sulfate2015
- Author(s)
  Nishimura Y, McLaughlin NP, Pan J, Goldstein S, Hafenstein S, Shimizu H, Winkler JD, Bergelson JM
- Journal Title
  
  PLoS Pathogens
  
  Volume: 11 Issue: 10 Pages: e1005184-e1005184
- DOI
  10.1371/journal.ppat.1005184
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08512, KAKENHI-PROJECT-25293111
[Journal Article] An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses2015
- Author(s)
  Zhang Y, Yan D, Zhu S, Nishimura Y, Ye X, Wang D, Jorba J, Zhu H, An H, Shimizu H, Kew O, Xu W
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 17291-17291
- DOI
  10.1038/srep17291
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293111
[Journal Article] Development of an efficient entire-capsid-coding-region amplification method for direct detection of poliovirus from stool extracts2015
- Author(s)
  Arita M, Kilpatrick DR, Nakamura T, Burns CC, Bukbuk D, Oderinde SB, Oberste MS, Kew OM, Pallansch MA, Shimizu H
- Journal Title
  
  J Clin Microbiol
  
  Volume: 53 Issue: 1 Pages: 73-78
- DOI
  10.1128/jcm.02384-14
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-26860450
[Journal Article] The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model.2015
- Author(s)
  Kataoka C, Suzuki T, Kotani O, Iwata-Yoshikawa N, Nagata N, Ami Y, Wakita T, Nishimura Y, Shimizu H.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 11(7) Issue: 7 Pages: e1005033-e1005033
- DOI
  10.1371/journal.ppat.1005033
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860307, KAKENHI-PROJECT-25293111
[Journal Article] Establishment of a panel of in-house polyclonal antibodies for the diagnosis of enterovirus infections2014
- Author(s)
  Kotani O, Iwata-Yoshikawa N, Suzuki T, Sato Y, Nakajima N, Koike S, Iwasaki T, Sata T, Yamashita　T, Minagawa H, Taguchi F, Hasegawa H, Shimizu H, Nagata N
- Journal Title
  
  Neuropathology
  
  Volume: 35 Issue: 2 Pages: 107-121
- DOI
  10.1111/neup.12171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390116, KAKENHI-PLANNED-24115006, KAKENHI-PROJECT-26860307, KAKENHI-PROJECT-25450431, KAKENHI-PROJECT-25293111
[Journal Article] Surveillance of hand, foot, and mouth disease for a vaccine2014
- Author(s)
  Shimizu H, Nakashima K
- Journal Title
  
  Lancet Infect Dis
  
  Volume: 14 Issue: 4 Pages: 262-3
- DOI
  10.1016/s1473-3099(13)70330-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-25293111
[Journal Article] Genetic diversity of circulating Saffold viruses in Pakistan and Afghanistan2014
- Author(s)
  Naeem A, Hosomi T, Nishimura Y, Alam MM, Oka T, Zaidi SS, Shimizu H
- Journal Title
  
  J Gen Virol
  
  Volume: 95 Issue: 9 Pages: 1945-1957
- DOI
  10.1099/vir.0.066498-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293111
[Journal Article] Oxysterol-binding protein (OSBP) family I is the target of minor enviroxime-like compounds2013
- Author(s)
  Arita M, Kojima H, Nagano T, Okabe T, Wakita T, Shimizu H
- Journal Title
  
  J Virol
  
  Volume: 87 Issue: 8 Pages: 4252-4260
- DOI
  10.1128/jvi.03546-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092, KAKENHI-PLANNED-24115003
[Journal Article] A Strain-Specific Epitope of Enterovirus 71 Identified by Cryo-Electron Microscopy of the Complex with Fab from Neutralizing Antibody2013
- Author(s)
  Lee H, Cifuente JO, Ashley RE, Conway JF, Makhov AM, Tano Y, Shimizu H, Nishimura Y, Hafenstein S
- Journal Title
  
  J Virol
  
  Volume: 87 Issue: 21 Pages: 11363-11370
- DOI
  10.1128/jvi.01926-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-25293111
[Journal Article] Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation2013
- Author(s)
  Fukuhara M, Iwami S, Sato K, Nishimura Y, Shimizu H, Aihara K, Koyanagi Y
- Journal Title
  
  J Virol
  
  Volume: 87 Issue: 1 Pages: 701-705
- DOI
  10.1128/jvi.01453-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-23659229, KAKENHI-PROJECT-23790500, KAKENHI-PLANNED-24115008
[Journal Article] A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit2013
- Author(s)
  Yasui Y, Makino T, Hanaoka N, Shimizu H, Kanou K, Kobayashi M, Konagaya M, Fujimoto T
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 66 Pages: 564-566
- NAID
  130003390346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293111
[Journal Article] Clinical Manifestations of Coxsackievirus A6 Infection Associated with a Major Outbreak of Hand, Foot, and Mouth Disease in Japan2013
- Author(s)
  Kobayashi M, Makino T, Hanaoka N, Shimizu H, Enomoto M, Okabe N, Kanou K, Konagaya M, Oishi K, Fujimoto T
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 66 Issue: 3 Pages: 260-261
- DOI
  10.7883/yoken.66.260
- NAID
  130003381685
- ISSN
  1344-6304, 1884-2836
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Enterovirus 71 Binding to PSGL-1 on Leukocytes : VP1-145 Acts as a Molecular Switch to Control Receptor Interaction2013
- Author(s)
  Nishimura Y, Lee H, Hafenstein S, Kataoka C, Wakita T, Bergelson JM, Shimizu H
- Journal Title
  
  PLoS Pathog
  
  Volume: 9 Issue: 7 Pages: e1003511-e1003511
- DOI
  10.1371/journal.ppat.1003511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-23590554, KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-25860832
[Journal Article] Clinical manifestations of coxsackievirus a6 infection associated with a major outbreak of hand, foot, and mouth disease in Japan2013
- Author(s)
  Kobayashi M, Makino T, Hanaoka N, Shimizu H, Enomoto M, Okabe N, Kanou K, Konagaya M, Oishi K, Fujimoto T
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 66 Pages: 260-261
- NAID
  130003381685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293111
[Journal Article] A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit2013
- Author(s)
  Yasui Y, Makino T, Hanaoka N, Shimizu H, Kanou K, Kobayashi M, Konagaya M, Fujimoto T
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 66 Issue: 6 Pages: 564-566
- DOI
  10.7883/yoken.66.564
- NAID
  130003390346
- ISSN
  1344-6304, 1884-2836
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Multiple Independent Emergences of Type 2 Vaccine-Derived Polioviruses during a Large Outbreak in northern Nigeria2013
- Author(s)
  Burns CC et al.
- Journal Title
  
  J Virol
  
  Volume: 87 Issue: 9 Pages: 4907-4922
- DOI
  10.1128/jvi.02954-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-25293111
[Journal Article] 東アジア地域を中心とした手足口病流行の現状2013
- Author(s)
  清水博之
- Journal Title
  
  感染症
  
  Volume: 43
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Valosin-Containing Protein (VCP/p97) Is Required for Poliovirus Replication and Is Involved in Cellular Protein Secretion Pathway in Poliovirus Infection2012
- Author(s)
  Arita M, Wakita T, Shimizu H
- Journal Title
  
  J Virol
  
  Volume: 86 Issue: 10 Pages: 5541-5553
- DOI
  10.1128/jvi.00114-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] 手足口病の問題点2012
- Author(s)
  清水博之
- Journal Title
  
  小児科
  
  Volume: 53 Pages: 751-758
- NAID
  40019344625
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Cellular receptors for human enterovirus species A2012
- Author(s)
  Nishimura Y, Shimizu H
- Journal Title
  
  Front Microbiol
  
  Volume: 3 Pages: 105-105
- DOI
  10.3389/fmicb.2012.00105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6, Japan, 20112012
- Author(s)
  Fujimoto T, Iizuka S, Enomoto M, Abe K, Yamashita K, Hanaoka N, Okabe N, Yoshida H, Yasui Y, Kobayashi M, Fujii Y, Tanaka H, Yamamoto M, Shimizu H
- Journal Title
  
  Emerg Infect Dis
  
  Volume: 18 Issue: 2 Pages: 337-339
- DOI
  10.3201/eid1802.111147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Enterovirus 71 encephalomyelitis and Japanese encephalitis can be distinguished by topographic distribution of inflammation and specific intraneuronal detection of viral antigen and RNA in the central nervous system2012
- Author(s)
  Wong KT, Ng KY, Ong KC, Ng WF, Shankar SK, Mahadevan A, Radotra B, Su JI, Lau G, Ling AE, Chan KP, Macorelles P, Desai AS, Ravi V, Nagata N, Shimizu H, Takasaki T
- Journal Title
  
  Neuropath Appl Neuro
  
  Volume: 38(1365-2990.2011.01247.x) Pages: 443-453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Development of a transcription-reverse transcription concerted reaction method for specific detection of human enterovirus 71 from clinical specimen2012
- Author(s)
  Nakajima N, Kitamori Y, Ohnaka S, Mitoma Y, Mizuta K, Wakita T, Shimizu H, Arita M
- Journal Title
  
  J Clin Microbiol
  
  Volume: 50 Issue: 5 Pages: 1764-1768
- DOI
  10.1128/jcm.00394-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] 手足口病特集「感染症動向2013」2012
- Author(s)
  清水博之
- Journal Title
  
  メディカル朝日
  
  Volume: 1 Pages: 28-30
- NAID
  40019550130
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Phosphatidylinositol-4 kinase III beta is a target of enviroxime-like compounds for anti-poliovirus activity2011
- Author(s)
  Arita M, Kojima H, Nagano T, Okabe T, Wakita T, Shimizu H
- Journal Title
  
  J Virol
  
  Volume: 85 Issue: 5 Pages: 2364-2372
- DOI
  10.1128/jvi.02249-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-12011
- Author(s)
  Miyamura K, Nishimura Y, Abo M, Wakita T, and Shimizu H
- Journal Title
  
  J Gen Virol
  
  Volume: 92 Issue: 2 Pages: 287-291
- DOI
  10.1099/vir.0.022418-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] A bifunctional anti-enterovirus compound that inhibits replication and early stage of enterovirus 71 infection2010
- Author(s)
  Arita M, Takebe Y, Wakita T, and Shimizu H
- Journal Title
  
  J Gen Virol
  
  Volume: 91 Issue: 11 Pages: 2734-44
- DOI
  10.1099/vir.0.023374-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection2010
- Author(s)
  Nishimura Y, Wakita T, and Shimizu H
- Journal Title
  
  PLoS Pathog
  
  Volume: 6 Issue: 11 Pages: e1001174-e1001174
- DOI
  10.1371/journal.ppat.1001174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390092
[Journal Article] 手足口病の大規模流行と原因ウイルス2010
- Author(s)
  清水博之
- Journal Title
  
  日本医事新報
  
  Volume: 4673 Pages: 91-91
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] マウスモデルにおけるエンテロウイルスＤ６８の神経病原性2019
- Author(s)
  永田典代、宮崎誠、斎藤博之、柴田ちひろ、ドゥアンイェンハイ、荒尾雄二郎、岩田（吉河）奈織子、清水博之、長谷川秀樹
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03626
[Presentation] Pathogenicity of recent Coxsackievirus B2 isolates in adult mice2018
- Author(s)
  Nagata N, Iwata-Yoshikawa N, Doan YH, Shimizu H, Hasegawa H.
- Organizer
  Europic 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Development of a flaccid paralysis mouse model after infection with enterovirus D682018
- Author(s)
  Miyazaki M, Saito H, Shibata C, Yen DH, Arao Y, Iwata-Yoshikawa N, Hasegawa H, Shimizu H, Nagata N
- Organizer
  Europic 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] A cluster of cases with acute flaccid myelitis coincident with an enterovirus D68 outbreak in Japan, 2015,A respiratory“neurovirulent”? enterovirus.2018
- Author(s)
  Shimizu H
- Organizer
  International Workshop on Laboratory Diagnosis for Enterovirus
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] An Outbreak of Enterovirus D68 in August-December 2015 in Japan as an emerging“neurovirulent” enterovirus infection2018
- Author(s)
  Shimizu H
- Organizer
  Lessons Learned since 1998 Enterovirus A71 Epidemic in Taiwan Contributions and Implications
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Cis-allosteric regulation of the interaction surfaces of enterovirus A71 capsid protein by the VP1 single amino acid residue at position 1452018
- Author(s)
  Kotani O, Yokoyama M, Fujii K, Kobayashi K, Nishimura Y, Nagata N, Shimizu H, Koike S, Sato H
- Organizer
  Europic 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Understanding of the pathogenesis of enterovirus 71 infection based on the identification of the receptors2018
- Author(s)
  Shimizu H
- Organizer
  The 20nd International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Nationwide survey of acute flaccid paralysis in August-December 2015 during an enterovirus D68 outbreak in Japan2018
- Author(s)
  Shimizu H
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program Viral Diseases Panel Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] エンテロウイルスD68のウイルス学的性状2017
- Author(s)
  清水博之
- Organizer
  第22回日本神経感染症学会学術大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Enterovirus D68 outbreak in Japan during autumn 20152017
- Author(s)
  Shimizu H
- Organizer
  The 3rd Symposium on Research and Quality Control of Vaccines
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] エンテロウイルスD68型感染後の弛緩性麻痺発現マウスモデルの構築2017
- Author(s)
  宮崎誠、斎藤博之、柴田ちひろ、YEN HAI DOAN、荒尾雄二郎、岩田奈織子、長谷川秀樹、清水博之、永田典代
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] 感染マウスモデルを用いたサフォードウイルスの脱髄病変形成メカニズムの解明2017
- Author(s)
  萩原圭、小谷治、岩田奈織子、長谷川秀樹、清水博之、永田典代
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Detection of Enterovirus D68 Based on the National Epidemiological Surveillance of Infectious Diseases System in Japan from 2005 to 20152016
- Author(s)
  Kinoshita H, Arima Y, Sunagawa T, Tanaka-Taya K, Hanaoka N, Fujimoto T, Oishi K, Shimizu H
- Organizer
  Europic 2016
- Place of Presentation
  Switzerland
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Prediction of enterovirus A71 functional region for the viral encapsidation2016
- Author(s)
  Kotani O, Yokoyama M, Nishimura Y, Nagata N, Shimizu H, Sato H
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] 世界ポリオ根絶計画の進捗と残された課題2016
- Author(s)
  清水博之
- Organizer
  感染研シンポジウムWHO the expanded program on immunization (EPI) と麻疹・ポリオの排除・根絶
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Outbreak of type 1 vaccine-derived poliovirus in Lao People's Democratic Republic in 2015-20162016
- Author(s)
  Shimizu H, Vongphrachanh P, Khamphaphongphane B, Sengkeopraseuth B, Nakamura T, Nishimura Y, Arita M, Wada J, Yoshida H, Schluter WW, Datta SS
- Organizer
  Europic 2016
- Place of Presentation
  Switzerland
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Current Outbreaks of Acute Flaccid Paralysis in Laos and Japan2016
- Author(s)
  Shimizu H
- Organizer
  NIID International Seminar on Infectious Diseases
- Place of Presentation
  東京
- Year and Date
  2016-01-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] Saffold virus in vivo passages drive the structural evolution of the capsid protein for enhancing replication fitness in neural cells2016
- Author(s)
  Kotani O, Yokoyama M, Iwata-Yoshikawa N, Suzuki T, Hasegawa H, Shimizu H, Sato H, Nagata N
- Organizer
  Europic 2016
- Place of Presentation
  Switzerland
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Virulence Of Recent Coxsackievirus B2 Isolates In A Neonatal Mouse Model2016
- Author(s)
  Nagata N, Ushioda W, Nakamura T, Agoh M, Iizuka S, Kotani O, Iwata-Yoshikawa N, Shimizu H, Hasegawa H
- Organizer
  Europic 2016
- Place of Presentation
  Switzerland
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] The VP1 amino acid residue 145 of EV71 is a virulence determinant in a cynomolgus monkey model2016
- Author(s)
  Fujii K, Sudaka Y, Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O, Ami Y, Shimizu H, Nagata N, Koike K
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] he VP1 amino acid residue 145 of EV71 is a virulence determinant in SCARB2-dependent infection2016
- Author(s)
  Fujii K, Sudaka Y, Ayumi Imura, Takashino A, Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O, Ami Y, Shimizu H, Nagata N, Koike K
- Organizer
  Europic 2016
- Place of Presentation
  Switzerland
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05200
[Presentation] Development of direct detection method of polioviruses from environmental samples2015
- Author(s)
  Nakamura T, Arita M, Shimizu H
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] The pathogenesis of a Saffold virus isolate from upper respiratory inflammation in a mouse model2015
- Author(s)
  Yamada S, Kotani O, Iwata-Yoshikawa N, Hasegawa H, Shimizu H, Nagata N
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] NF449 interacts with the 5-fold vertex of the enterovirus 71 capsid to prevent virus attachment to PSGL-1 and heparan sulfate2015
- Author(s)
  Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, Winkler JD, Bergelson JM
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] 不活化ポリオワクチン導入によるポリオの予防接種状況および抗体保有状況の推移について（2012～2014年度感染症流行予測調査より）2015
- Author(s)
  佐藤弘、多屋馨子、大石和徳、清水博之
- Organizer
  第47回日本小児感染症学会学術集会
- Place of Presentation
  福島
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] A molecular mechanism of adaptive evolution of Saffold virus type 3 in cerebellum of mouse2015
- Author(s)
  Kotani O, Yokoyama M, Suzuki T, Iwata-Yosikawa N, Hasegawa H, Shimizu H, Sato H, Nagata N
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] 2011年と2012年の北部ベトナムにおける手足口病の流行状況2015
- Author(s)
  片岡周子、Tran Thi Nguyen Hoa、中村朋史、Nguyen Thi Hien Thanh、清水博之
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] ポリオウイルス病原体管理に関するWHO行動計画(GAP III)と今後の課題2015
- Author(s)
  清水博之
- Organizer
  第15回日本バイオセーフティ学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] The suramin derivative NF449 interacts with the 5-fold vertex of the enterovirus 71 capsid to prevent virus attachment to PSGL-1 and heparan sulfate2015
- Author(s)
  Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, Winkler JD, Bergelson JM
- Organizer
  10th Asia-Pacific Congress of Medical Virology 2015
- Place of Presentation
  台北
- Year and Date
  2015-10-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] Immunogenicity of Booster Doses of the Inactivated Polio Vaccine among Japanese adult travelers2015
- Author(s)
  Fukushima S, Nakano T, Shimizu H, Hamada A
- Organizer
  The 14th Conference of International society of Travel Medicine
- Place of Presentation
  ケベック
- Year and Date
  2015-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] VP1-145 of enterovirus 71 is one of the determinants for pathogenicity in a cynomolgus monkey model2014
- Author(s)
  Kataoka C, Nishimura Y, Suzuki T, Kotani O, Iwata N, Nagata A, Ami Y, Shimizu H
- Organizer
  Europic 2014
- Place of Presentation
  Belgium
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] A comparison of human enterovirus detection in experimentally infected neonatal mice using immunohistochemistry2014
- Author(s)
  Nagata N, Kotani O, Iwata N, Suzuki T, Sato Y, Koike S, Iwasaki T, Taguchi F, Hasegawa H, Shimizu H
- Organizer
  Europic 2014
- Place of Presentation
  Belgium
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] VP1-145 of enterovirus 71 is one of the determinants for pathogenicity in a cynomolgus monkey model2014
- Author(s)
  Kataoka C, Nishimura Y, Suzuki T, Kotani O, Iwata N, Nagata A, Ami Y, Shimizu H
- Organizer
  Europic 2014
- Place of Presentation
  Belgium
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] Comparative analyses of the pathogenicity of two isolates of Saffold virus in neonatal mouse2014
- Author(s)
  Kotani O, Asif N, Suzuki T, Iwata N, Nakajima N, Katano H, Hosomi T, Tsukagoshi H, Hasegawa H, Taguchi F, Shimizu H, Nagata N
- Organizer
  Europic 2014
- Place of Presentation
  Belgium
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] The molecular basis of the interaction between EV71 and PSGL-1 from structural and functional standpoints2014
- Author(s)
  Shimizu H
- Organizer
  TLL Seminar, Temasek Life Science Laboratory
- Place of Presentation
  Singapore
- Year and Date
  2014-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] A comparison of human enterovirus detection in experimentally infected neonatal mice using immunohistochemistry.2014
- Author(s)
  Nagata N, Kotani O, Iwata N, Suzuki T, Sato Y, Koike S, Iwasaki T, Taguchi F, Hasegawa H, Shimizu H
- Organizer
  18th International Picornavirus meeting (Europic 2014)
- Place of Presentation
  Blankenberge, Belgium
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] Comparative analyses of the pathogenicity of two isolates of Saffold virus in neonatal mouse.2014
- Author(s)
  Kotani O, Asif N, Suzuki T, Iwata N, Nakajima N, Katano H, Hosomi T, Tsukagoshi H, Hasegawa H, Taguchi F, Shimizu H, Nagata N
- Organizer
  18th International Picornavirus meeting (Europic 2014)
- Place of Presentation
  Blankenberge, Belgium
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] Structural and functional basis of the interaction between enterovirus 71 and a cellular receptor, PSGL-12014
- Author(s)
  Shimizu H
- Organizer
  Protein Island Matsuyama International Symposium
- Place of Presentation
  Matsuyama,Ehime
- Year and Date
  2014-09-17
- Invited
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] 世界ポリオ根絶計画とポリオワクチンのこれから2014
- Author(s)
  清水博之
- Organizer
  第46回日本小児感染症学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-10-19
- Invited
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] Molecular basis of virus-host interaction and pathogenesis of enterovirus 71 infection2014
- Author(s)
  Shimizu H
- Organizer
  Monto Ho Memorial Lectures on Enterovirus 71, 2014 International Symposium on Infectious Disease and Signal Transduction
- Place of Presentation
  Tainan, Taiwan
- Year and Date
  2014-11-02
- Invited
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] Infection with dual microRNA-targeted coxsackievirus B3 abrogates its pathogenicity retaining oncolytic activity.2013
- Author(s)
  Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
- Organizer
  第19回日本遺伝子治療学会
- Place of Presentation
  岡山
- Year and Date
  2013-07-04
- Data Source
  KAKENHI-PROJECT-23240133
[Presentation] Differential susceptibility of cancer stem cells and cancer cells undergoing epithelial-mesenchymal transition to oncolysis by CVB3 infection.2013
- Author(s)
  Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Chika Sakamoto, Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
- Organizer
  第19回日本遺伝子治療学会
- Place of Presentation
  岡山
- Year and Date
  2013-07-04
- Data Source
  KAKENHI-PROJECT-23240133
[Presentation] ヒトカルジオウイルス(Saffold virus)の新生仔マウス小脳における病理学的解析2013
- Author(s)
  小谷治、鈴木忠樹、Naeem Asif、岩田奈織子、中島典子、片野晴隆、田口文広、長谷川秀樹、清水博之、永田典代
- Organizer
  感染症若手フォーラム2013
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] CVB3 infection elicits potent oncolytic activity against lung cancer stem cells.2013
- Author(s)
  Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Chika Sakamoto, Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu Yoichi Nakanishi, Kenzaburo Tani
- Organizer
  The 16th Annual Meeting of American Society of Gene and Cell Therapy.
- Place of Presentation
  Salt Lake City, UT
- Year and Date
  2013-05-15
- Data Source
  KAKENHI-PROJECT-23240133
[Presentation] Current status of hand, foot, and mouth disease outbreaks and EV71 infection in Japan and Asian countries2013
- Author(s)
  Shimizu H
- Organizer
  The 7th China-Korea-Japan Forum on Communicable Disease Control and Prevention
- Place of Presentation
  Beijing, China
- Year and Date
  2013-11-25
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] MicroRNA-targeted coxsackievirus B3 infection markedly reduces its toxicity without losing its original oncolytic activity.2013
- Author(s)
  Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
- Organizer
  Therapeutics Discovery Symposium Asia Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013 Meeting On ‘RNA Regulation to Delivery, Programming to Pluripotency & Therapeutics’
- Place of Presentation
  Tokyo
- Year and Date
  2013-11-25
- Data Source
  KAKENHI-PROJECT-23240133
[Presentation] エンテロウイルス71のカニクイザルにおける病原性の解析2013
- Author(s)
  片岡周子、西村順裕、鈴木忠樹、小谷治、岩田奈織子、永田典代、網康至、清水博之
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] エンテロウイルス71と受容体PSGL-1との結合:VP1-145は受容体特異性を制御する分子スイッチである2013
- Author(s)
  西村順裕、Hyunwook Lee、Susan Hafenstein、片岡周子、脇田隆字、Jeffrey M. Bergelson、清水博之
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] Hand, Foot, and Mouth Disease and infectious agent surveillance in Japan2013
- Author(s)
  Shimizu H
- Organizer
  International Workshop on Hand, Foot and Mouth Disease
- Place of Presentation
  Hanoi, Vietnam
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] エンテロウイルス71のカニクイザルにおける病原性の解析2013
- Author(s)
  片岡周子　西村順裕　鈴木忠樹　小谷治　岩田奈織子　永田典代　網康至　清水博之
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] Hand, foot, and mouth disease and infectious agent surveillance in Japan2013
- Author(s)
  Shimizu H
- Organizer
  International Workshop on Hand, Foot and Mouth Disease
- Place of Presentation
  Hanoi, Viet Nam
- Invited
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] and, Foot, and Mouth Disease and infectious agent surveillance in Japan2013
- Author(s)
  Shimizu H
- Organizer
  International Workshop on Hand, Foot and Mouth Disease
- Place of Presentation
  Hanoi
- Invited
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] アジアにおける手足口病とエンテロウイルス感染症流行の現状2013
- Author(s)
  清水博之
- Organizer
  第87回日本感染症学会学術講演会・第61回日本化学療法学会総会合同学会、シンポジウム「世界的視野でみる感染症疫学とその対策」
- Place of Presentation
  横浜市
- Year and Date
  2013-06-05
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] コクサッキーウイルスB2実験室株脳内接種後のマウスにおける水頭症の発症機序2013
- Author(s)
  潮田和佳、小谷治、岩田奈織子、鈴木忠樹、中島典子、長谷川秀樹、清水博之、永田典代
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] olecular Epidemiology and Virulence (viral) factors of EV712013
- Author(s)
  Shimizu H
- Organizer
  International Workshop on Hand, Foot and Mouth Disease
- Place of Presentation
  Hanoi
- Invited
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] MicroRNA-regulated coxsackievirus B3 abrogates its pathogenicity retaining oncolytic activity.2013
- Author(s)
  Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
- Organizer
  The 23rd Hot Spring Harbor International Symposium, Recent Advances in Stem Cell Biology 2013
- Place of Presentation
  Fukuoka
- Year and Date
  2013-11-04
- Data Source
  KAKENHI-PROJECT-23240133
[Presentation] エンテロウイルス71と受容体PSGL-1との結合：VP1-145は受容体特異性を制御する分子スイッチである2013
- Author(s)
  西村順裕、Hyunwook Lee、Susan Hafenstein、片岡周子、脇田隆字、Jeffrey M. Bergelson、清水博之
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] RD-A細胞を用いたHuman enterovirus Aの分離2013
- Author(s)
  飯塚節子、清水博之
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] MicroRNA-targeted coxsackievirus B3 infection markedly reduces its pathogenicity retaining oncolytic activity.2013
- Author(s)
  Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23240133
[Presentation] Dual microRNA-regulated oncolytic coxsackievirus B3 infection displays antitumor activity with attenuated pathogenicity in mice.2013
- Author(s)
  Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
- Organizer
  The 16th Annual Meeting of American Society of Gene and Cell Therapy
- Place of Presentation
  Salt Lake City, UT
- Year and Date
  2013-05-15
- Data Source
  KAKENHI-PROJECT-23240133
[Presentation] Molecular Epidemiology and Virulence (viral) factors of EV712013
- Author(s)
  Shimizu H
- Organizer
  International Workshop on Hand, Foot and Mouth Disease
- Place of Presentation
  Hanoi, Viet Nam
- Invited
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] Molecular Epidemiology and Virulence (viral) factors of EV712013
- Author(s)
  Shimizu H
- Organizer
  International Workshop on Hand, Foot and Mouth Disease
- Place of Presentation
  Hanoi, Vietnam
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] CVB3 infection displays different oncolytic activities against cancer stem cells and cancer cells undergoing EMT.2013
- Author(s)
  Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Chika Sakamoto, Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23240133
[Presentation] エンテロウイルス71のカニクイザルにおける病原性の解析2013
- Author(s)
  片岡周子、西村順裕、鈴木忠樹、小谷治岩田奈織子、永田典代、網康至、清水博之
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] 新生仔マウスを用いたSaffold virus小脳継代株の作出とその病原性の解析2013
- Author(s)
  小谷治、Naeem Asif、鈴木忠樹、岩田奈織子、中島典子、片野晴隆、長谷川秀樹、田口文広、清水博之、永田典代
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] 新生仔マウスにおける新規ヒトカルジオウイルス（Saffold virus）の神経病原性の解析2012
- Author(s)
  小谷治、鈴木忠樹、Naeem Asif、岩田奈織子、中島典子、片野晴隆、田口文広、長谷川秀樹、清水博之、永田典代
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] Genetic analysis of PSGL-1-tropic enterovirus 71 isolates from clinical samples2012
- Author(s)
  Umami RN, Hosomi T, Nishimura Y, Shimizu H
- Organizer
  The 17th Meeting of the European Study Group on the Molecular Biology of Picornaviruses
- Place of Presentation
  Saint Raphael, France
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] 新生仔マウスにおける新規ヒトカルジオウイルス(Saffold virus)の神経病原性の解析2012
- Author(s)
  小谷治、鈴木忠樹、Naeem Asif、岩田奈織子、中島典子、片野晴隆、田口文広、長谷川秀樹、清水博之、永田典代
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23590554
[Presentation] Valosin containing protein (VCP/p97) is required for replication of poliovirus and inhibition of cellular protein secretion caused by viral proteins2012
- Author(s)
  Arita M, Wakita T, Shimizu H
- Organizer
  The 17th Meeting of the European Study Group on the Molecular Biology of Picornaviruses.
- Place of Presentation
  Saint Raphael, France
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] VCP/p97はポリオウイルスの複製に必要とされる新規宿主因子でありウイルス感染における細胞蛋白質分泌経路に関与する2012
- Author(s)
  有田峰太郎、脇田隆字、清水博之
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-14
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] The cryoEM structure of EV71 bound by fragments of neutralizing antibody predicts a mechanism of neutralization by crosslinking and competition with PSGL-12012
- Author(s)
  Lee H, Cifuente JO, Carnegie MS, Markoff A, Conway J, Shimizu H, Tano Y, Nishimura Y, Hafenstein S
- Organizer
  The 17th Meeting of the European Study Group on the Molecular Biology of Picornaviruses
- Place of Presentation
  Saint Raphael, France
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] Hand, foot, and mouth disease outbreaks in the Asia-Pacific region2011
- Author(s)
  Shimizu H
- Organizer
  Pasteur Institute in Ho Chi Minh City 120 Years for Control and Prevention of Communicable Diseases
- Place of Presentation
  Ho Chi Minh City
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] アジア地域におけるエンテロウイルス71感染症の流行2011
- Author(s)
  清水博之
- Organizer
  第52回日本臨床ウイルス学会
- Place of Presentation
  津市
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] PSGL-1-dependent and-independent replication of enterovirus 712011
- Author(s)
  Shimizu H
- Organizer
  The 1st International Symposium of Vaccine Development against Human Hand-Foot-and-Mouth Diseases
- Place of Presentation
  ZhuNan, Taiwan
- Year and Date
  2011-09-04
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] Analysis of amino acid determinants of enterovirus 71 responsible for the PSGL-1-binding phenotype2011
- Author(s)
  Nishimura Y, Wakita T, Shimizu H
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] Hand, foot, and mouth disease outbreaks in the Asia-Pacific region2011
- Author(s)
  Shimizu H
- Organizer
  Pasteur Institute in Ho Chi Minh City 120 Years for Control and Prevention of Communicable Diseases
- Place of Presentation
  Ho Chi Minh City, Viet Nam
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] PSGL-1-dependent and -independent replication of enterovirus 712011
- Author(s)
  Shimizu H
- Organizer
  The 1st International Symposium of Vaccine Development against Human Hand-Foot-and-Mouth Diseases
- Place of Presentation
  ZhuNan, Taiwan
- Year and Date
  2011-09-04
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] コクサッキーA16型ウイルスの白血球系細胞株における増殖の解析2010
- Author(s)
  西村順裕、脇田隆字、清水博之
- Organizer
  第58回日本ウイルス学会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection2010
- Author(s)
  Nishimura Y, Wakita T, Shimizu H
- Organizer
  16th Meeting of the European Study Group on the Molecular Biology of Picornaviruses
- Place of Presentation
  Scotland
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] Involvement of host and viral factors for interaction of PSGL-1 with enterovirus 712010
- Author(s)
  Nishimura Y, Miyamura K, Shimizu H
- Organizer
  The 2^<nd> International Vaccine Symposium
- Place of Presentation
  Taiwan
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] Characterization of cellular and viral factors involved in PSGL-1-dependent viral replication of enterovirus 712010
- Author(s)
  Nishimura Y, Miyamura K, Shimizu H
- Organizer
  EV71 workshop at National Cheng Kung University
- Place of Presentation
  Taiwan
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] ウイルス受容体特異性を応用したポリオウイルス直接検出法の開発
- Author(s)
  中村朋史、有田峰太郎、清水博之
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] エンテロウイルス71のカニクイザルにおける病原性の解析
- Author(s)
  8)片岡周子、西村順裕、鈴木忠樹、小谷治、岩田奈織子、永田典代、網康至、清水博之
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25293111
[Presentation] Genetic and Phenotypic Diversity of Enterovirus 71
- Author(s)
  Shimizu H
- Organizer
  Current Progress in Enterovirus 71 Research in the Asia-Pacific Region
- Place of Presentation
  Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-22390092
[Presentation] アジアにおける手足口病とエンテロウイルス感染症流行の現状
- Author(s)
  清水博之
- Organizer
  第87回日本感染症学会学術講演会・第61回日本化学療法学会総会合同学会
- Place of Presentation
  横浜市
- Invited
- Data Source
  KAKENHI-PROJECT-25293111

1. NAGATA Noriyo (30270648)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
2. NISHIMURA Yorihiro (00392316)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
3. TANI Kenzaburo (00183864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
4. KOIKE Satoshi (30195630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. FUJII Ken (10580201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YAMAYOSHI Seiya (50529534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IWATA Naoko (10360695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
8. SUZUKI Tadaki (30527180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
9. KATAOKA CHIKAKO (10646623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. MIYAMURA Tatsuo (90100099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOSHIDA Hiromu (30270656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YONEYAMA Tetsuo (90100106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HAGIWARA Akio (10100091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. IGARASHI Akira (40029773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HASEBE Futoshi (20253693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MORITA Kouichi (40182240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TADANO Masayuki (80179712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. AMI Yasusi (10202699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 松浦善治 (50157252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 武田直和 (90132894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KOTANI Osamu

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
22. PHAN Van Tu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. RADU Crainic

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. DELPEYROUX F

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. CRAINIC Radu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. AIZAWA Shihoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. OKITSU Shoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 早川智

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. TRINH DUYQUANG

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. PHAM Ngan

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SHIMIZU HIROYUKI 清水 博之

清水 博之 シミズ ヒロユキ

SHIMIZU Hiroyuki 清水 博之

Research Projects

Research Products

Co-Researchers

Study on pathogenesis of flaccid paralysis caused by enterovirus D68 using animal models

Principal Investigator

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Review Section

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The involvement of amino acid mutations of the capsid ptoteins of enterovirus A71 in viral genetic diversity and neuropathogenesisPrincipal Investigator

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Changes in receptor specificity and pathogenesis associated with mutations of capsid amino acids of enterovirus 71 in host adaptationPrincipal Investigator

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Clinical development of the novel oncolytic coxsackievirus B3 targeting malignant tumors

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Molecular basis of enterovirus 71 neuropathogenicity

Principal Investigator

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Pathogenesis of Saffold virus infection in animal models

Principal Investigator

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The molecular basis of PSGL-1-dependent viral replication and pathogenesis in enterovirus 71 infectionPrincipal Investigator

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VIROLOGICAL AND PATHOLOGICAL ANALYSIS OF ENTEROVIRUS 71 ENCEPHALITIS IN THE WESTERN PACIFIC REGIONPrincipal Investigator

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Study on the RNA Helicase Activity of the Flavivirus NS3 Proteins

Principal Investigator

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ポリオウイルス2C蛋白質機能の阻害剤を用いた解析Principal Investigator

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Genetic analysis of wild polioviruses and its ecology

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[Book] ウイルス検査法2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] グローバル時代のウイルス感染症2018

Author(s)

SHIMIZU HIROYUKI 清水博之

清水博之シミズヒロユキ

SHIMIZU Hiroyuki 清水博之

[Book] 感染症予防必携 (第３版)　「急性灰白髄炎」の項を担当2015

[Book] まるわかりワクチン Q&A　Q25およびQ26を担当2015

[Book] 臨床医のための呼吸器・消化管ウイルス感染症消化器ウイルス篇　エンテロウイルス-ポリオウイルスおよび非ポリオエンテロウイルス」の項を分担執筆2014