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SHIMIZU HIROYUKI  清水 博之

Researcher Number 90270644
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-2987-2377
External Links
Affiliation *help 2016 – 2018 : 国立感染症研究所, ウイルス第二部, 室長
2014 – 2016 : 国立感染症研究所, その他部局等, その他
2014 : 国立感染症研究所, ウイルス第2部, 室長
2010 – 2014 : 国立感染症研究所, ウイルス第二部, 室長
2013 : 国立感染症研究所, その他部局等, 室長 … More
2003 : NATIONAL INSTITUTE OF INFECTIOUS DISEASES, DEPARTMENT OF VIROLOGY II, CHIEF, ウイルス第2部・室長, 厚生労働技官
2001 – 2003 : 国立感染症研究所, ウイルス第二部, 室長
2000 : 国立感染症研究所, ウイルス二部, 主任研究官
2000 : Institute of Infectious Diseases Senior Researcher, ウイルス第2部, 厚生技官
1999 : 国立感染症研究所, ウイルス第二部, 厚生技官
1997 : National Institute of Infectious Diseases, Dept.of Virology II, ウイルス第二部, 研究員
1996 : 国立予防衛生研究所, ウイルス第二部, 研究員 Less
Review Section/Research Field
Principal Investigator
Virology / Virology / Biological pharmacy
Except Principal Investigator
Virology / Virology / Clinical oncology
Keywords
Principal Investigator
エンテロウイルス71 / エンテロウイルス / 手足口病 / 病原性 / 受容体 / PSGL-1 / カニクイザル / 動物モデル / 感染症 / 感染モデル … More / レセプター / ウイルス / ENTEROVIRUS71 / マレーシア:中国:タイ:ベトナム / エンテロウイルス感染症 / 感染動物モデル / ENCEPHALITIS / CNS INFECTION / 国際情報交換 / 2C蛋白質 / 分子進化 / ベンズイミダゾール / 中枢神経感染 / 脳炎 / ENTEROVIRUS / HAND, FOOT AND MOUTH DISEASE / 分子疫学 / NTPase / エンテロウイルスA71 / 抗ウイルス剤 / MOLECULAR EPIDEMIOLOGY / ポリオウイルス … More
Except Principal Investigator
NS3 protein / ATPase / RNA belicase / JEV / ウイルス / 感染症 / wild strain / miR-217 / ポリオ根絶計画 / ウイルス受容体 / 一般毒性試験 / エンテロウイルス71 / 腫瘍溶解性ウイルス / 医薬品医療機器総合機構 / コクサッキーウイルスB群3型 / poliomyelitis / 動物モデル / 病原性 / miR-1 / 野生株 / ウイルス製剤製造 / リコンビナントウイルス / コクサッキーウイルス(CV)B3 / トランスジェニックマウス / 塩基配列 / 神経病原性 / 病理学 / GMP準拠 / ワクチン / 腫瘍溶解ウイルス / GM-CSF / ポリオワクチン / RNA helicase / 一般毒性試 / oral polio vaccine / nucleotide sequence / miRNA / ウイルス製造 / 遺伝子改変CVB3 / マウス感染モデル / GMP / 腫瘍溶解性ウイルス療法 / ポリオ / microRNA / CVB3精製 / ポリオウイルス / コクサッキーウイルス / 神経毒力 / 担癌マウスモデル / 密度勾配遠心法 / 顆粒球マクロファージコロニー刺激因子 / polioeradication program / 脳神経疾患 / miRNA相補配列挿入CVB3 / 顆粒球マクロファージ刺激因子 Less
  • Research Projects

    (10results)
  • Research Products

    (117results)
  • Co-Researchers

    (39People)
  •  The involvement of amino acid mutations of the capsid ptoteins of enterovirus A71 in viral genetic diversity and neuropathogenesisPrincipal InvestigatorOngoing

    • Principal Investigator
      清水 博之
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases
  •  Changes in receptor specificity and pathogenesis associated with mutations of capsid amino acids of enterovirus 71 in host adaptationPrincipal Investigator

    • Principal Investigator
      SHIMIZU HIROYUKI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases
  •  Clinical development of the novel oncolytic coxsackievirus B3 targeting malignant tumors

    • Principal Investigator
      TANI Kenzaburo
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Clinical oncology
    • Research Institution
      Kyushu University
  •  Molecular basis of enterovirus 71 neuropathogenicity

    • Principal Investigator
      KOIKE Satoshi
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Pathogenesis of Saffold virus infection in animal models

    • Principal Investigator
      NAGATA Noriyo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases
  •  The molecular basis of PSGL-1-dependent viral replication and pathogenesis in enterovirus 71 infectionPrincipal Investigator

    • Principal Investigator
      SHIMIZU HIROYUKI
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases
  •  VIROLOGICAL AND PATHOLOGICAL ANALYSIS OF ENTEROVIRUS 71 ENCEPHALITIS IN THE WESTERN PACIFIC REGIONPrincipal Investigator

    • Principal Investigator
      SHIMIZU Hiroyuki
    • Project Period (FY)
      2000 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      NATIONAL INSTITUTE OF INFECTIOUS DISEASES
  •  Study on the RNA Helicase Activity of the Flavivirus NS3 Proteins

    • Principal Investigator
      IGARASHI Akira
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Institute of Tropical Medicine, Nagasaki University
  •  ポリオウイルス2C蛋白質機能の阻害剤を用いた解析Principal Investigator

    • Principal Investigator
      清水 博之
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      国立予防衛生研究所
  •  Genetic analysis of wild polioviruses and its ecology

    • Principal Investigator
      MIYAMURA Tatsuo
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Virology
    • Research Institution
      National Institute of Infectious Diseases

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

  • [Book] まるわかりワクチン Q&A Q25およびQ26を担当2015

    • Author(s)
      清水博之
    • Total Pages
      407
    • Publisher
      日本医事新報社
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Book] 感染症予防必携 (第3版) 「急性灰白髄炎」の項を担当2015

    • Author(s)
      清水博之
    • Total Pages
      634
    • Publisher
      日本公衆衛生協会
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Book] 臨床医のための呼吸器・消化管ウイルス感染症 消化器ウイルス篇 エンテロウイルス-ポリオウイルスおよび非ポリオエンテロウイルス」の項を分担執筆2014

    • Author(s)
      清水博之
    • Total Pages
      135
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Journal Article] Detection of nineteen enteric viruses in raw sewage in Japan2018

    • Author(s)
      Thongprachum A, Fujimoto T, Takanashi S, Saito H, Okitsu S, Shimizu H, Khamrin P, Maneekarn N, Hayakawa S, Ushijima H
    • Journal Title

      Infect Genet Evol

      Volume : in pres

    • DOI
      10.1016/j.meegid.2018.05.006
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Journal Article] Acute Flaccid Myelitis Collaborative Study I. Clinical Features of Acute Flaccid Myelitis Temporally Associated With an Enterovirus D68 Outbreak: Results of a Nationwide Survey of Acute Flaccid Paralysis in Japan, August-December 20152018

    • Author(s)
      Chong PF, Kira R, Mori H, Okumura A, Torisu H, Yasumoto S, Shimizu H, Fujimoto T, Hanaoka N, Kusunoki S, Takahashi T, Oishi K, Tanaka-Taya K
    • Journal Title

      Clin Infect Dis

      Volume : 66 Pages : 653-664

    • DOI
      10.1093/cid/cix860
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Journal Article] VP1 amino acid residue 145 of enterovirus 71 is a key residue for its receptor attachment and resistance to neutralizing antibody during cynomolgus monkey infection2018

    • Author(s)
      Fujii K, Sudaka Y, Takashino A, Kobayashi K, Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O, Ami Y, Shimizu H, Nagata N, Mizuta K, Matsuzaki Y, Koike S.
    • Journal Title

      J Virol

      Volume : in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Journal Article] Detection and genetic characterization of enterovirus strains circulating among children with acute gastroenteritis in Japan during 2014-20162018

    • Author(s)
      Ngan Thi Kim Pham、Aksara Thongprachum、Quang Duy Trinh、Shoko Okitsu、Shihoko Komine-Aizawa、Hiroyuki Shimizu、Satoshi Hayakawa、Hiroshi Ushijima
    • Journal Title

      Infect Genet Evol

      Volume : 61 Pages : 16-19

    • DOI
      10.1016/j.meegid.2018.03.009
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11160, KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-16H05360
  • [Journal Article] Intracerebral inoculation of mouse-passaged Saffold virus type 3 affects cerebellar development in neonatal mice.2018

    • Author(s)
      Kotani O, Suzuki T, Yokoyama M, Iwata-Yoshikawa N, Nakajima N, Sato H, Hasegawa H, Taguchi F, Shimizu H, Nagata N
    • Journal Title

      Journal of Virology

      Volume : in press Pages : 00864-16

    • DOI
      10.1128/jvi.00864-16
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-26860307, KAKENHI-PROJECT-15K08511, KAKENHI-PROJECT-16K08824
  • [Journal Article] Multiplex RT-PCR for rapid detection of viruses commonly causing diarrhea in pediatric patients.2017

    • Author(s)
      Thongprachum A, Khamrin P, Thi Kim Pham N, Takanashi S, Okitsu S, Shimizu H, Maneekarn N, Hayakawa S, Ushijima H
    • Journal Title

      J Med Virol.

      Volume : 89 Pages : 818-824

    • DOI
      10.1002/jmv.24711
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-16H05360, KAKENHI-PROJECT-26860434, KAKENHI-PROJECT-17H04341
  • [Journal Article] Cosavirus (family Picornaviridae) in pigs in Thailand and Japan. .2016

    • Author(s)
      Okitsu S, Khamrin P, Hanaoka N, Thongprachum A, Takanashi S, Fujimoto T, Mizuguchi M, Shimizu H, Hayakawa S, Maneekarn N, Ushijima H
    • Journal Title

      Arch Virol.

      Volume : 161 Pages : 159-163

    • DOI
      10.1007/s00705-015-2637-2
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460791, KAKENHI-PROJECT-24390266, KAKENHI-PROJECT-24390382, KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-15F15117, KAKENHI-PROJECT-26860434
  • [Journal Article] Human rhinovirus infections in hospitalized children: clinical, epidemiological and virological features2016

    • Author(s)
      Tran DN, Trinh QD, Pham NT, Pham TM, Ha MT, Nguyen TQ, Okitsu S, Shimizu H, Hayakawa S, Mizuguchi M, Ushijima H.
    • Journal Title

      Epidemiol Infect

      Volume : 144 Pages : 346-54

    • DOI
      10.1017/s0950268815000953
    • Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-14F03406, KAKENHI-PROJECT-25460791, KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-24390266
  • [Journal Article] Neuropathogenicity of two Saffold virus type 3 isolates in mouse models2016

    • Author(s)
      Kotani O, Naeem A, Suzuki T, Iwata-Yoshikawa N, Sato Y, Nakajima N, Hosomi T, Tsukagoshi H, Kozawa K, Hasegawa H, Taguchi F, Shimizu H, Nagata N.
    • Journal Title

      PLoS One

      Volume : 11 Pages : 1-29

    • DOI
      10.1371/journal.pone.0148184
    • Peer Reviewed / Int'l Joint Research / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08511, KAKENHI-PROJECT-25450431, KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-16H05200, KAKENHI-PROJECT-26860307
  • [Journal Article] Adult Case of Acute Flaccid Paralysis with Enterovirus D68 Detected in the CSF.2016

    • Author(s)
      Kimura K, Fukushima T, Katada N, Shimizu H, Nakamura T, Fujimoto T, Hanaoka N, Tanaka-Taya K, Makino K
    • Journal Title

      Neurology: Clinical Practice

      Volume : in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Journal Article] Development and introduction of inactivated poliovirus vaccines derived from Sabin strains in Japan2016

    • Author(s)
      Shimizu H
    • Journal Title

      Vaccine

      Volume : 34 Pages : 1975-1985

    • DOI
      10.1016/j.vaccine.2014.11.015
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-16H05200
  • [Journal Article] エンテロウイルス71ワクチン開発の現状2016

    • Author(s)
      清水博之
    • Journal Title

      小児科

      Volume : 57 Pages : 929-936

    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Journal Article] Development of an efficient entire-capsid-coding-region amplification method for direct detection of poliovirus from stool extracts2015

    • Author(s)
      Arita M, Kilpatrick DR, Nakamura T, Burns CC, Bukbuk D, Oderinde SB, Oberste MS, Kew OM, Pallansch MA, Shimizu H
    • Journal Title

      Journal of clinical microbiology

      Volume : 53 Pages : 73-78

    • DOI
      10.1128/jcm.02384-14
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-26860450
  • [Journal Article] The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate2015

    • Author(s)
      Nishimura Y, McLaughlin NP, Pan J, Goldstein S, Hafenstein S, Shimizu H, Winkler JD, Bergelson JM
    • Journal Title

      PLoS Pathog

      Volume : 11

    • DOI
      10.1371/journal.ppat.1005184
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08512, KAKENHI-PROJECT-25293111
  • [Journal Article] Establishment of a panel of in-house polyclonal antibodies for the diagnosis of enterovirus infections2015

    • Author(s)
      Kotani O, Iwata-Yoshikawa N, Suzuki T, Sato Y, Nakajima N, Koike S, Iwasaki T, Sata T, Yamashita T, Minagawa H, Taguchi F, Hasegawa H, Shimizu H, Nagata N.
    • Journal Title

      Neuropathology

      Volume : 35(2) Pages : 107-21

    • DOI
      10.1111/neup.12171
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860307, KAKENHI-PROJECT-25450431, KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-23390116, KAKENHI-PLANNED-24115006
  • [Journal Article] An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses2015

    • Author(s)
      Zhang Y, Yan D, Zhu S, Nishimura Y, Ye X, Wang D, Jorba J, Zhu H, An H, Shimizu H, Kew O, Xu W
    • Journal Title

      Scientific Reports

      Volume : 5 Pages : 17291-17291

    • DOI
      10.1038/srep17291
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Journal Article] The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model2015

    • Author(s)
      Kataoka C, Suzuki T, Kotani O, Iwata-Yoshikawa N, Nagata N, Ami Y, Wakita T, Nishimura Y, Shimizu H.
    • Journal Title

      PLoS Pathog

      Volume : 11(7)

    • DOI
      10.1371/journal.ppat.1005033
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860307, KAKENHI-PROJECT-25293111
  • [Journal Article] Genetic diversity of circulating Saffold viruses in Pakistan and Afghanistan2014

    • Author(s)
      Naeem A, Hosomi T, Nishimura Y, Alam MM, Oka T, Zaidi SS, Shimizu H
    • Journal Title

      J Gen Virol

      Volume : 95 Pages : 1945-1957

    • DOI
      10.1099/vir.0.066498-0
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Journal Article] Surveillance of hand, foot, and mouth disease for a vaccine2014

    • Author(s)
      Shimizu H, Nakashima K
    • Journal Title

      Lancet Infect Dis

      Volume : 14 Pages : 262-3

    • DOI
      10.1016/s1473-3099(13)70330-x
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-25293111
  • [Journal Article] Clinical manifestations of coxsackievirus a6 infection associated with a major outbreak of hand, foot, and mouth disease in Japan2013

    • Author(s)
      Kobayashi M, Makino T, Hanaoka N, Shimizu H, Enomoto M, Okabe N, Kanou K, Konagaya M, Oishi K, Fujimoto T
    • Journal Title

      Jpn J Infect Dis

      Volume : 66 Pages : 260-261

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Journal Article] A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit2013

    • Author(s)
      Yasui Y, Makino T, Hanaoka N, Shimizu H, Kanou K, Kobayashi M, Konagaya M, Fujimoto T
    • Journal Title

      Jpn J Infect Dis

      Volume : 66 Pages : 564-566

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Journal Article] Multiple Independent Emergences of Type 2 Vaccine-Derived Polioviruses during a Large Outbreak in northern Nigeria2013

    • Author(s)
      Burns CC et al.
    • Journal Title

      J Virol

      Volume : 87 Pages : 4907-4922

    • DOI
      10.1128/jvi.02954-12
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-25293111
  • [Journal Article] Oxysterol-binding protein family I is the target of minor enviroxime-like compounds2013

    • Author(s)
      Arita M, Kojima H, Nagano T, Okabe T, Wakita T, Shimizu H
    • Journal Title

      J Virol

      Volume : 87 Pages : 4252-4260

    • DOI
      10.1128/jvi.03546-12
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092, KAKENHI-PLANNED-24115003
  • [Journal Article] Quantification of the dynamics of enterovirus 71 infection by experimental-mathematical investigation.2013

    • Author(s)
      Fukuhara M, Iwami S, Sato K, Nishimura Y, Shimizu H, Aihara K, Koyanagi Y
    • Journal Title

      J. Virol

      Volume : 87 Pages : 701-705

    • DOI
      10.1128/jvi.01453-12
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-23659229, KAKENHI-PROJECT-23790500, KAKENHI-PLANNED-24115008
  • [Journal Article] Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction2013

    • Author(s)
      Nishimura Y, Lee H, Hafenstein S, Kataoka C, Wakita T, Bergelson JM, Shimizu H
    • Journal Title

      PLOS Pathogen

      Volume : 9

    • DOI
      10.1371/journal.ppat.1003511
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-23590554, KAKENHI-PLANNED-24115003, KAKENHI-PROJECT-25293111, KAKENHI-PROJECT-25860832
  • [Journal Article] Clinical manifestations of coxsackievirus A6 infection associated with a major outbreak of hand, foot, and mouth disease in Japan2013

    • Author(s)
      Kobayashi M, Makino T, Hanaoka N, Shimizu H, Enomoto M, Okabe N, Kanou K, Konagaya M, Oishi K, Fujimoto T
    • Journal Title

      Jpn J Infect Dis

      Volume : 66 Pages : 260-261

    • DOI
      10.7883/yoken.66.260
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit2013

    • Author(s)
      Yasui Y, Makino T, Hanaoka N, Shimizu H, Kanou K, Kobayashi M, Konagaya M, Fujimoto T
    • Journal Title

      Jpn J Infect Dis

      Volume : 66 Pages : 564-566

    • DOI
      10.7883/yoken.66.564
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] A Strain-Specific Epitope of Enterovirus 71 Identified by Cryo-Electron Microscopy of the Complex with Fab from Neutralizing Antibody2013

    • Author(s)
      Lee H, Cifuente JO, Ashley RE, Conway JF, Makhov AM, Tano Y, Shimizu H, Nishimura Y, Hafenstein S
    • Journal Title

      J Virol

      Volume : 87 Pages : 11363-11370

    • DOI
      10.1128/jvi.01926-13
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092, KAKENHI-PROJECT-25293111
  • [Journal Article] 東アジア地域を中心とした手足口病流行の現状2013

    • Author(s)
      清水博之
    • Journal Title

      感染症

      Volume : 43

    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] Enterovirus 71 encephalomyelitis and Japanese encephalitis can be distinguished by topographic distribution of inflammation and specific intraneuronal detection of viral antigen and RNA in the central nervous system2012

    • Author(s)
      Wong KT, Ng KY, Ong KC, Ng WF, Shankar SK, Mahadevan A, Radotra B, Su JI, Lau G, Ling AE, Chan KP, Macorelles P, Desai AS, Ravi V, Nagata N, Shimizu H, Takasaki T
    • Journal Title

      Neuropath Appl Neuro

      Volume : 38(1365-2990.2011.01247.x) Pages : 443-453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] Development of a transcription-reverse transcription concerted reaction method for specific detection of human enterovirus 71 from clinical specimen2012

    • Author(s)
      Nakajima N, Kitamori Y, Ohnaka S, Mitoma Y, Mizuta K, Wakita T, Shimizu H, Arita M
    • Journal Title

      J Clin Microbiol

      Volume : 50 Pages : 1764-1768

    • DOI
      10.1128/jcm.00394-12
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] Cellular receptors for human enterovirus species A2012

    • Author(s)
      Nishimura Y, Shimizu H
    • Journal Title

      Front Microbiol

      Volume : 3 Pages : 105-105

    • DOI
      10.3389/fmicb.2012.00105
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] Valosin-Containing Protein (VCP/p97) Is Required for Poliovirus Replication and Is Involved in Cellular Protein Secretion Pathway in Poliovirus Infection2012

    • Author(s)
      Arita M, Wakita T, Shimizu H
    • Journal Title

      J Virol

      Volume : 86 Pages : 5541-5553

    • DOI
      10.1128/jvi.00114-12
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6, Japan, 20112012

    • Author(s)
      Fujimoto T, Iizuka S, Enomoto M, Abe K, Yamashita K, Hanaoka N, Okabe N, Yoshida H, Yasui Y, Kobayashi M, Fujii Y, Tanaka H, Yamamoto M, Shimizu H
    • Journal Title

      Emerg Infect Dis

      Volume : 18 Pages : 337-339

    • DOI
      10.3201/eid1802.111147
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] 手足口病特集「感染症動向2013」2012

    • Author(s)
      清水博之
    • Journal Title

      メディカル朝日

      Volume : 1 Pages : 28-30

    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] 手足口病の問題点2012

    • Author(s)
      清水博之
    • Journal Title

      小児科

      Volume : 53 Pages : 751-758

    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] Phosphatidylinositol-4 kinase III beta is a target of enviroxime-like compounds for anti-poliovirus activity2011

    • Author(s)
      Arita M, Kojima H, Nagano T, Okabe T, Wakita T, Shimizu H
    • Journal Title

      J Virol

      Volume : 85 Pages : 2364-2372

    • DOI
      10.1128/jvi.02249-10
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-12011

    • Author(s)
      Miyamura K, Nishimura Y, Abo M, Wakita T, and Shimizu H
    • Journal Title

      J Gen Virol

      Volume : 92 Pages : 287-291

    • DOI
      10.1099/vir.0.022418-0
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection2010

    • Author(s)
      Nishimura Y, Wakita T, and Shimizu H
    • Journal Title

      PLoS Pathog

      Volume : 6

    • DOI
      10.1371/journal.ppat.1001174
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] 手足口病の大規模流行と原因ウイルス2010

    • Author(s)
      清水博之
    • Journal Title

      日本医事新報

      Volume : 4673 Pages : 91-91

    • Data Source
      KAKENHI-PROJECT-22390092
  • [Journal Article] A bifunctional anti-enterovirus compound that inhibits replication and early stage of enterovirus 71 infection2010

    • Author(s)
      Arita M, Takebe Y, Wakita T, and Shimizu H
    • Journal Title

      J Gen Virol

      Volume : 91 Pages : 2734-44

    • DOI
      10.1099/vir.0.023374-0
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] Understanding of the pathogenesis of enterovirus 71 infection based on the identification of the receptors2018

    • Author(s)
      Shimizu H
    • Organizer
      The 20nd International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] Nationwide survey of acute flaccid paralysis in August-December 2015 during an enterovirus D68 outbreak in Japan2018

    • Author(s)
      Shimizu H
    • Organizer
      U.S.-Japan Cooperative Medical Sciences Program Viral Diseases Panel Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] 感染マウスモデルを用いたサフォードウイルスの脱髄病変形成メカニズムの解明2017

    • Author(s)
      萩原圭、小谷治、岩田奈織子、長谷川秀樹、清水博之、永田典代
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] エンテロウイルスD68のウイルス学的性状2017

    • Author(s)
      清水博之
    • Organizer
      第22回日本神経感染症学会学術大会
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] Enterovirus D68 outbreak in Japan during autumn 20152017

    • Author(s)
      Shimizu H
    • Organizer
      The 3rd Symposium on Research and Quality Control of Vaccines
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] エンテロウイルスD68型感染後の弛緩性麻痺発現マウスモデルの構築2017

    • Author(s)
      宮崎誠、斎藤博之、柴田ちひろ、YEN HAI DOAN、荒尾雄二郎、岩田奈織子、長谷川秀樹、清水博之、永田典代
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] Saffold virus in vivo passages drive the structural evolution of the capsid protein for enhancing replication fitness in neural cells2016

    • Author(s)
      Kotani O, Yokoyama M, Iwata-Yoshikawa N, Suzuki T, Hasegawa H, Shimizu H, Sato H, Nagata N
    • Organizer
      Europic 2016
    • Place of Presentation
      Switzerland
    • Year and Date
      2016-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] Detection of Enterovirus D68 Based on the National Epidemiological Surveillance of Infectious Diseases System in Japan from 2005 to 20152016

    • Author(s)
      Kinoshita H, Arima Y, Sunagawa T, Tanaka-Taya K, Hanaoka N, Fujimoto T, Oishi K, Shimizu H
    • Organizer
      Europic 2016
    • Place of Presentation
      Switzerland
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] Virulence Of Recent Coxsackievirus B2 Isolates In A Neonatal Mouse Model2016

    • Author(s)
      Nagata N, Ushioda W, Nakamura T, Agoh M, Iizuka S, Kotani O, Iwata-Yoshikawa N, Shimizu H, Hasegawa H
    • Organizer
      Europic 2016
    • Place of Presentation
      Switzerland
    • Year and Date
      2016-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] Outbreak of type 1 vaccine-derived poliovirus in Lao People's Democratic Republic in 2015-20162016

    • Author(s)
      Shimizu H, Vongphrachanh P, Khamphaphongphane B, Sengkeopraseuth B, Nakamura T, Nishimura Y, Arita M, Wada J, Yoshida H, Schluter WW, Datta SS
    • Organizer
      Europic 2016
    • Place of Presentation
      Switzerland
    • Year and Date
      2016-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] Prediction of enterovirus A71 functional region for the viral encapsidation2016

    • Author(s)
      Kotani O, Yokoyama M, Nishimura Y, Nagata N, Shimizu H, Sato H
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] 世界ポリオ根絶計画の進捗と残された課題2016

    • Author(s)
      清水博之
    • Organizer
      感染研シンポジウムWHO the expanded program on immunization (EPI) と麻疹・ポリオの排除・根絶
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] The VP1 amino acid residue 145 of EV71 is a virulence determinant in a cynomolgus monkey model2016

    • Author(s)
      Fujii K, Sudaka Y, Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O, Ami Y, Shimizu H, Nagata N, Koike K
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] Current Outbreaks of Acute Flaccid Paralysis in Laos and Japan2016

    • Author(s)
      Shimizu H
    • Organizer
      NIID International Seminar on Infectious Diseases
    • Place of Presentation
      東京
    • Year and Date
      2016-01-26
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] he VP1 amino acid residue 145 of EV71 is a virulence determinant in SCARB2-dependent infection2016

    • Author(s)
      Fujii K, Sudaka Y, Ayumi Imura, Takashino A, Kataoka C, Suzuki T, Iwata-Yoshikawa N, Kotani O, Ami Y, Shimizu H, Nagata N, Koike K
    • Organizer
      Europic 2016
    • Place of Presentation
      Switzerland
    • Year and Date
      2016-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05200
  • [Presentation] 不活化ポリオワクチン導入によるポリオの予防接種状況および抗体保有状況の推移について(2012~2014年度感染症流行予測調査より)2015

    • Author(s)
      佐藤 弘、多屋馨子、大石和徳、清水博之
    • Organizer
      第47回日本小児感染症学会学術集会
    • Place of Presentation
      福島
    • Year and Date
      2015-10-31
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] ポリオウイルス病原体管理に関するWHO行動計画(GAP III)と今後の課題2015

    • Author(s)
      清水博之
    • Organizer
      第15回日本バイオセーフティ学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-15
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] Immunogenicity of Booster Doses of the Inactivated Polio Vaccine among Japanese adult travelers2015

    • Author(s)
      Fukushima S, Nakano T, Shimizu H, Hamada A
    • Organizer
      The 14th Conference of International society of Travel Medicine
    • Place of Presentation
      ケベック
    • Year and Date
      2015-05-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] The suramin derivative NF449 interacts with the 5-fold vertex of the enterovirus 71 capsid to prevent virus attachment to PSGL-1 and heparan sulfate2015

    • Author(s)
      Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, Winkler JD, Bergelson JM
    • Organizer
      10th Asia-Pacific Congress of Medical Virology 2015
    • Place of Presentation
      台北
    • Year and Date
      2015-10-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] NF449 interacts with the 5-fold vertex of the enterovirus 71 capsid to prevent virus attachment to PSGL-1 and heparan sulfate2015

    • Author(s)
      Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, Winkler JD, Bergelson JM
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] Development of direct detection method of polioviruses from environmental samples2015

    • Author(s)
      Nakamura T, Arita M, Shimizu H
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] 2011年と2012年の北部ベトナムにおける手足口病の流行状況2015

    • Author(s)
      片岡周子、Tran Thi Nguyen Hoa、中村朋史、Nguyen Thi Hien Thanh、清水博之
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] A molecular mechanism of adaptive evolution of Saffold virus type 3 in cerebellum of mouse2015

    • Author(s)
      Kotani O, Yokoyama M, Suzuki T, Iwata-Yosikawa N, Hasegawa H, Shimizu H, Sato H, Nagata N
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] The pathogenesis of a Saffold virus isolate from upper respiratory inflammation in a mouse model2015

    • Author(s)
      Yamada S, Kotani O, Iwata-Yoshikawa N, Hasegawa H, Shimizu H, Nagata N
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] A comparison of human enterovirus detection in experimentally infected neonatal mice using immunohistochemistry2014

    • Author(s)
      Nagata N, Kotani O, Iwata N, Suzuki T, Sato Y, Koike S, Iwasaki T, Taguchi F, Hasegawa H, Shimizu H
    • Organizer
      Europic 2014
    • Place of Presentation
      Belgium
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] Comparative analyses of the pathogenicity of two isolates of Saffold virus in neonatal mouse2014

    • Author(s)
      Kotani O, Asif N, Suzuki T, Iwata N, Nakajima N, Katano H, Hosomi T, Tsukagoshi H, Hasegawa H, Taguchi F, Shimizu H, Nagata N
    • Organizer
      Europic 2014
    • Place of Presentation
      Belgium
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] VP1-145 of enterovirus 71 is one of the determinants for pathogenicity in a cynomolgus monkey model2014

    • Author(s)
      Kataoka C, Nishimura Y, Suzuki T, Kotani O, Iwata N, Nagata A, Ami Y, Shimizu H
    • Organizer
      Europic 2014
    • Place of Presentation
      Belgium
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] The molecular basis of the interaction between EV71 and PSGL-1 from structural and functional standpoints2014

    • Author(s)
      Shimizu H
    • Organizer
      TLL Seminar, Temasek Life Science Laboratory
    • Place of Presentation
      Singapore
    • Year and Date
      2014-09-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] Molecular basis of virus-host interaction and pathogenesis of enterovirus 71 infection2014

    • Author(s)
      Shimizu H
    • Organizer
      Monto Ho Memorial Lectures on Enterovirus 71, 2014 International Symposium on Infectious Disease and Signal Transduction
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2014-11-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] Structural and functional basis of the interaction between enterovirus 71 and a cellular receptor, PSGL-12014

    • Author(s)
      Shimizu H
    • Organizer
      Protein Island Matsuyama International Symposium
    • Place of Presentation
      Matsuyama,Ehime
    • Year and Date
      2014-09-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] 世界ポリオ根絶計画とポリオワクチンのこれから2014

    • Author(s)
      清水博之
    • Organizer
      第46回日本小児感染症学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-19
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] VP1-145 of enterovirus 71 is one of the determinants for pathogenicity in a cynomolgus monkey model2014

    • Author(s)
      Kataoka C, Nishimura Y, Suzuki T, Kotani O, Iwata N, Nagata A, Ami Y, Shimizu H
    • Organizer
      Europic 2014
    • Place of Presentation
      Belgium
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] Comparative analyses of the pathogenicity of two isolates of Saffold virus in neonatal mouse.2014

    • Author(s)
      Kotani O, Asif N, Suzuki T, Iwata N, Nakajima N, Katano H, Hosomi T, Tsukagoshi H, Hasegawa H, Taguchi F, Shimizu H, Nagata N
    • Organizer
      18th International Picornavirus meeting (Europic 2014)
    • Place of Presentation
      Blankenberge, Belgium
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] A comparison of human enterovirus detection in experimentally infected neonatal mice using immunohistochemistry.2014

    • Author(s)
      Nagata N, Kotani O, Iwata N, Suzuki T, Sato Y, Koike S, Iwasaki T, Taguchi F, Hasegawa H, Shimizu H
    • Organizer
      18th International Picornavirus meeting (Europic 2014)
    • Place of Presentation
      Blankenberge, Belgium
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] Differential susceptibility of cancer stem cells and cancer cells undergoing epithelial-mesenchymal transition to oncolysis by CVB3 infection.2013

    • Author(s)
      Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Chika Sakamoto, Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
    • Organizer
      第19回日本遺伝子治療学会
    • Place of Presentation
      岡山
    • Year and Date
      2013-07-04
    • Data Source
      KAKENHI-PROJECT-23240133
  • [Presentation] Infection with dual microRNA-targeted coxsackievirus B3 abrogates its pathogenicity retaining oncolytic activity.2013

    • Author(s)
      Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
    • Organizer
      第19回日本遺伝子治療学会
    • Place of Presentation
      岡山
    • Year and Date
      2013-07-04
    • Data Source
      KAKENHI-PROJECT-23240133
  • [Presentation] CVB3 infection elicits potent oncolytic activity against lung cancer stem cells.2013

    • Author(s)
      Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Chika Sakamoto, Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu Yoichi Nakanishi, Kenzaburo Tani
    • Organizer
      The 16th Annual Meeting of American Society of Gene and Cell Therapy.
    • Place of Presentation
      Salt Lake City, UT
    • Year and Date
      2013-05-15
    • Data Source
      KAKENHI-PROJECT-23240133
  • [Presentation] ヒトカルジオウイルス(Saffold virus)の新生仔マウス小脳における病理学的解析2013

    • Author(s)
      小谷治、鈴木忠樹、Naeem Asif、岩田奈織子、中島典子、片野晴隆、田口文広、長谷川秀樹、清水博之、永田典代
    • Organizer
      感染症若手フォーラム2013
    • Place of Presentation
      北海道
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] エンテロウイルス71のカニクイザルにおける病原性の解析2013

    • Author(s)
      片岡周子、西村順裕、鈴木忠樹、小谷治、岩田奈織子、永田典代、網康至、清水博之
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] 新生仔マウスを用いたSaffold virus小脳継代株の作出とその病原性の解析2013

    • Author(s)
      小谷治、Naeem Asif、鈴木忠樹、岩田奈織子、中島典子、片野晴隆、長谷川秀樹、田口文広、清水博之、永田典代
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] Dual microRNA-regulated oncolytic coxsackievirus B3 infection displays antitumor activity with attenuated pathogenicity in mice.2013

    • Author(s)
      Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
    • Organizer
      The 16th Annual Meeting of American Society of Gene and Cell Therapy
    • Place of Presentation
      Salt Lake City, UT
    • Year and Date
      2013-05-15
    • Data Source
      KAKENHI-PROJECT-23240133
  • [Presentation] MicroRNA-regulated coxsackievirus B3 abrogates its pathogenicity retaining oncolytic activity.2013

    • Author(s)
      Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
    • Organizer
      The 23rd Hot Spring Harbor International Symposium, Recent Advances in Stem Cell Biology 2013
    • Place of Presentation
      Fukuoka
    • Year and Date
      2013-11-04
    • Data Source
      KAKENHI-PROJECT-23240133
  • [Presentation] MicroRNA-targeted coxsackievirus B3 infection markedly reduces its toxicity without losing its original oncolytic activity.2013

    • Author(s)
      Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
    • Organizer
      Therapeutics Discovery Symposium Asia Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013 Meeting On ‘RNA Regulation to Delivery, Programming to Pluripotency & Therapeutics’
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-11-25
    • Data Source
      KAKENHI-PROJECT-23240133
  • [Presentation] コクサッキーウイルスB2実験室株脳内接種後のマウスにおける水頭症の発症機序2013

    • Author(s)
      潮田和佳、小谷治、岩田奈織子、鈴木忠樹、中島典子、長谷川秀樹、清水博之、永田典代
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] CVB3 infection displays different oncolytic activities against cancer stem cells and cancer cells undergoing EMT.2013

    • Author(s)
      Miyako Sagara, Hiroyuki Inoue, Shohei Miyamoto, Chika Sakamoto, Yuki Nakano, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-03
    • Data Source
      KAKENHI-PROJECT-23240133
  • [Presentation] エンテロウイルス71と受容体PSGL-1との結合:VP1-145は受容体特異性を制御する分子スイッチである2013

    • Author(s)
      西村順裕、Hyunwook Lee、Susan Hafenstein、片岡周子、脇田隆字、Jeffrey M. Bergelson、清水博之
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] エンテロウイルス71のカニクイザルにおける病原性の解析2013

    • Author(s)
      片岡周子 西村順裕 鈴木忠樹 小谷治 岩田奈織子 永田典代 網康至 清水博之
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] Current status of hand, foot, and mouth disease outbreaks and EV71 infection in Japan and Asian countries2013

    • Author(s)
      Shimizu H
    • Organizer
      The 7th China-Korea-Japan Forum on Communicable Disease Control and Prevention
    • Place of Presentation
      Beijing, China
    • Year and Date
      2013-11-25
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] アジアにおける手足口病とエンテロウイルス感染症流行の現状2013

    • Author(s)
      清水博之
    • Organizer
      第87回日本感染症学会学術講演会・第61回日本化学療法学会総会合同学会、シンポジウム「世界的視野でみる感染症疫学とその対策」
    • Place of Presentation
      横浜市
    • Year and Date
      2013-06-05
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] and, Foot, and Mouth Disease and infectious agent surveillance in Japan2013

    • Author(s)
      Shimizu H
    • Organizer
      International Workshop on Hand, Foot and Mouth Disease
    • Place of Presentation
      Hanoi
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] エンテロウイルス71と受容体PSGL-1との結合:VP1-145は受容体特異性を制御する分子スイッチである2013

    • Author(s)
      西村順裕、Hyunwook Lee、Susan Hafenstein、片岡周子、脇田隆字、Jeffrey M. Bergelson、清水博之
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] エンテロウイルス71のカニクイザルにおける病原性の解析2013

    • Author(s)
      片岡周子、西村順裕、鈴木忠樹、小谷治岩田奈織子、永田典代、網康至、清水博之
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] RD-A細胞を用いたHuman enterovirus Aの分離2013

    • Author(s)
      飯塚節子、清水博之
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] Hand, Foot, and Mouth Disease and infectious agent surveillance in Japan2013

    • Author(s)
      Shimizu H
    • Organizer
      International Workshop on Hand, Foot and Mouth Disease
    • Place of Presentation
      Hanoi, Vietnam
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] MicroRNA-targeted coxsackievirus B3 infection markedly reduces its pathogenicity retaining oncolytic activity.2013

    • Author(s)
      Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara, Beibei Wang, Koichi Takayama, Hiroyuki Shimizu, Yoichi Nakanishi, Kenzaburo Tani
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-03
    • Data Source
      KAKENHI-PROJECT-23240133
  • [Presentation] 新生仔マウスにおける新規ヒトカルジオウイルス(Saffold virus)の神経病原性の解析2012

    • Author(s)
      小谷治、鈴木忠樹、Naeem Asif、岩田奈織子、中島典子、片野晴隆、田口文広、長谷川秀樹、清水博之、永田典代
    • Organizer
      第60回日本ウイルス学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] Genetic analysis of PSGL-1-tropic enterovirus 71 isolates from clinical samples2012

    • Author(s)
      Umami RN, Hosomi T, Nishimura Y, Shimizu H
    • Organizer
      The 17th Meeting of the European Study Group on the Molecular Biology of Picornaviruses
    • Place of Presentation
      Saint Raphael, France
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] The cryoEM structure of EV71 bound by fragments of neutralizing antibody predicts a mechanism of neutralization by crosslinking and competition with PSGL-12012

    • Author(s)
      Lee H, Cifuente JO, Carnegie MS, Markoff A, Conway J, Shimizu H, Tano Y, Nishimura Y, Hafenstein S
    • Organizer
      The 17th Meeting of the European Study Group on the Molecular Biology of Picornaviruses
    • Place of Presentation
      Saint Raphael, France
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] VCP/p97はポリオウイルスの複製に必要とされる新規宿主因子でありウイルス感染における細胞蛋白質分泌経路に関与する2012

    • Author(s)
      有田峰太郎、脇田隆字、清水博之
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-14
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] Valosin containing protein (VCP/p97) is required for replication of poliovirus and inhibition of cellular protein secretion caused by viral proteins2012

    • Author(s)
      Arita M, Wakita T, Shimizu H
    • Organizer
      The 17th Meeting of the European Study Group on the Molecular Biology of Picornaviruses.
    • Place of Presentation
      Saint Raphael, France
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] 新生仔マウスにおける新規ヒトカルジオウイルス(Saffold virus)の神経病原性の解析2012

    • Author(s)
      小谷 治、鈴木 忠樹、Naeem Asif、岩田 奈織子、中島 典子、片野 晴隆、田口 文広、長谷川 秀樹、清水 博之、永田 典代
    • Organizer
      第60回日本ウイルス学会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23590554
  • [Presentation] Hand, foot, and mouth disease outbreaks in the Asia-Pacific region2011

    • Author(s)
      Shimizu H
    • Organizer
      Pasteur Institute in Ho Chi Minh City 120 Years for Control and Prevention of Communicable Diseases
    • Place of Presentation
      Ho Chi Minh City
    • Year and Date
      2011-11-17
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] アジア地域におけるエンテロウイルス71感染症の流行2011

    • Author(s)
      清水博之
    • Organizer
      第52回日本臨床ウイルス学会
    • Place of Presentation
      津市
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] PSGL-1-dependent and -independent replication of enterovirus 712011

    • Author(s)
      Shimizu H
    • Organizer
      The 1st International Symposium of Vaccine Development against Human Hand-Foot-and-Mouth Diseases
    • Place of Presentation
      ZhuNan, Taiwan
    • Year and Date
      2011-09-04
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] Analysis of amino acid determinants of enterovirus 71 responsible for the PSGL-1-binding phenotype2011

    • Author(s)
      Nishimura Y, Wakita T, Shimizu H
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] コクサッキーA16型ウイルスの白血球系細胞株における増殖の解析2010

    • Author(s)
      西村順裕、脇田隆字、清水博之
    • Organizer
      第58回日本ウイルス学会
    • Place of Presentation
      徳島市
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] Characterization of cellular and viral factors involved in PSGL-1-dependent viral replication of enterovirus 712010

    • Author(s)
      Nishimura Y, Miyamura K, Shimizu H
    • Organizer
      EV71 workshop at National Cheng Kung University
    • Place of Presentation
      Taiwan
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] Involvement of host and viral factors for interaction of PSGL-1 with enterovirus 712010

    • Author(s)
      Nishimura Y, Miyamura K, Shimizu H
    • Organizer
      The 2^<nd> International Vaccine Symposium
    • Place of Presentation
      Taiwan
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection2010

    • Author(s)
      Nishimura Y, Wakita T, Shimizu H
    • Organizer
      16th Meeting of the European Study Group on the Molecular Biology of Picornaviruses
    • Place of Presentation
      Scotland
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] Genetic and Phenotypic Diversity of Enterovirus 71

    • Author(s)
      Shimizu H
    • Organizer
      Current Progress in Enterovirus 71 Research in the Asia-Pacific Region
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-22390092
  • [Presentation] アジアにおける手足口病とエンテロウイルス感染症流行の現状

    • Author(s)
      清水博之
    • Organizer
      第87回日本感染症学会学術講演会・第61回日本化学療法学会総会合同学会
    • Place of Presentation
      横浜市
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] エンテロウイルス71のカニクイザルにおける病原性の解析

    • Author(s)
      8)片岡周子、西村順裕、鈴木忠樹、小谷治、岩田奈織子、永田典代、網康至、清水博之
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-25293111
  • [Presentation] ウイルス受容体特異性を応用したポリオウイルス直接検出法の開発

    • Author(s)
      中村 朋史、有田 峰太郎、清水 博之
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-25293111
  • 1.  NAGATA Noriyo (30270648)
    # of Collaborated Projects : 3results
    # of Collaborated Products : 14results
  • 2.  NISHIMURA Yorihiro (00392316)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 28results
  • 3.  TANI Kenzaburo (00183864)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 8results
  • 4.  KOIKE Satoshi (30195630)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 1results
  • 5.  FUJII Ken (10580201)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 6.  YAMAYOSHI Seiya (50529534)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 7.  IWATA Naoko (10360695)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 10results
  • 8.  SUZUKI Tadaki (30527180)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 14results
  • 9.  KATAOKA CHIKAKO (10646623)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 7results
  • 10.  MIYAMURA Tatsuo (90100099)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 11.  YOSHIDA Hiromu (30270656)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 12.  YONEYAMA Tetsuo (90100106)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 13.  HAGIWARA Akio (10100091)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 14.  IGARASHI Akira (40029773)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 15.  HASEBE Futoshi (20253693)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 16.  MORITA Kouichi (40182240)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 17.  TADANO Masayuki (80179712)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 18.  AMI Yasusi (10202699)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 19.  松浦 善治 (50157252)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 20.  武田 直和 (90132894)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 21.  KOTANI Osamu
    # of Collaborated Projects : 1results
    # of Collaborated Products : 10results
  • 22.  PHAN Van Tu
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 23.  RADU Crainic
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 24.  DELPEYROUX F
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 25.  CRAINIC Radu
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 26.  OKITSU Shoko
    # of Collaborated Projects : 0results
    # of Collaborated Products : 3results
  • 27.  TAKANASHI Sayaka
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 28.  USHIJIMA Hiroshi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 4results
  • 29.  SHIMIZU Yuko
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 30.  HAYAKAWA Satoshi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 4results
  • 31.  THONGPRACHUM Aksara
    # of Collaborated Projects : 0results
    # of Collaborated Products : 4results
  • 32.  Nakamura Tomofumi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 33.  WAKITA Takaji
    # of Collaborated Projects : 0results
    # of Collaborated Products : 3results
  • 34.  PHAM NGAN
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 35.  田口 文広
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 36.  小柳 義夫
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 37.  佐藤 佳
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 38.  相澤 志保子
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 39.  TRINH DUYQUANG
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results

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