Kondo Kazunao 近藤一直

… Alternative Names

KONDO Kazunao 近藤一直

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Researcher Number	90270983
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2018: 藤田医科大学, 医学部, 教授 2015: 藤田保健衛生大学, 医学部, 教授 2012: 藤田保健衛生大学, 医学部, 教授 2005: Hamamatsu University School of Medicine, Dept of Pharmacology, Associate Professor, 医学部, 助教授 2004: 国立大学法人浜松医科大学, 医学部, 助教授 2000 – 2003: 浜松医科大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Experimental pathology / 応用薬理学・医療系薬学 / General pharmacology Except Principal Investigator General pharmacology / 応用薬理学・医療系薬学
Keywords	Principal Investigator 血管内膜肥厚 / Epigallocathechin gallate / cytokine / platelet / inflammation / 炎症性サイトカイン / サイトカイン / 血小板凝集 / 炎症 / intima thickening … More / atherosclerosis / オステオポンチン / 糖尿病 / 動脈硬化 / 光増感反応 / 細胞内シグナル / Boyden-chamber法 / 血小板由来増殖因子 / 細胞遊走 / 血管平滑筋 / ミッドカイン … More Except Principal Investigator テトラヒドロビオプテリン / 血管 / 持続勃起症 / 交感神経 / 高血圧 / 一酸化窒素 / ドパミン神経 / 不安定高血圧症 / Priapism （持続勃起症） / 持続勃起症（Priapism） / セピアプテリン還元酵素 / Priapism（持続勃起症） / 徐脈 / ノルアドレナリン / ドパミンニューロン / ドパミン / Heparin / Cerebral hemorrhage / Ischemic reperfusion / IIIa / GPIIb / 動物実験 / 脳梗塞 / ヘパリン / 脳出血 / 虚血・再灌流 / フェニルアラニン / ジストニア / 血管内皮細胞 / 一酸化窒素合成酵素 / チロシン水酸化酵素 / 生理活性物質 Less

Tetrahydrobiopterin-deficiency causes hypertension with fluctuation, bradycardia and priapism.
- Principal Investigator
  
  SUMI-ICHINOSE Chiho
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fujita Health University
Study on the disease induced by imbalance of tetrahydrobiopterin-metabolism and research on the mechanisms for protection against the state.
- Principal Investigator
  
  Sumi-Ichinose Chiho
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fujita Health University
Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease
- Principal Investigator
  
  SUMI-ICHINOSE Chiho
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fujita Health University
Origin of neointima cells and mechanism of intima thickening formation, using radiation chimera rat.Principal Investigator
- Principal Investigator
  
  KONDO Kazunao
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Hamamatsu University School of Medicine
Role of osteopontin in diabetic atherosclerosiPrincipal Investigator
- Principal Investigator
  
  KONDO Kazunao
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
ヘパリン結合性増殖因子ミッドカインが血管内膜肥厚におよぼす影響Principal Investigator
- Principal Investigator
  
  近藤一直
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Hamamatsu University School of Medicine
Pharmacological investigation of roles of cyclic flow reductions in the development of cerebral infarction
- Principal Investigator
  
  UMEMURA Kazuo
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Hamamatsu University School of Medicine

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.2017
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Hiroko Nomura, Kazuhisa Ikemoto, Tadayoshi Hata, Setsuko Katoh, Hiroshi Ichinose and Kazunao Kondo
- Journal Title
  
  Physiological Reports
  
  Volume: 5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08561
[Journal Article] Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.2014
- Author(s)
  Xu F, Sudo Y, Sanechika S, Yamashita J, Shimaguchi S, Honda S, Sumi-Ichinose C, Mori-Kojima M, Nakata R, Furuta T, Sakurai M, Sugimoto M, Soga T, Kondo K, Ichinose H.
- Journal Title
  
  FEBS Letters
  
  Volume: 588 Issue: 21 Pages: 3924-3931
- DOI
  10.1016/j.febslet.2014.09.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460346, KAKENHI-PROJECT-26462860
[Journal Article] Cilostazol Inhibits Cytokine-induced Tetrahydrobiopterin Biosynthesis in Human Umbilical Vein Endothelial Cells.2011
- Author(s)
  Hiroaki Shiraishi, Kazuhisa Ikemoto, Shin Tada, Yasuhiro Udagawa, Masatsugu, Ohtsuki, Chiho Sumi-Ichinose, Kazunao Kondo, and Takahide Nomura.
- Journal Title
  
  J Ather Thromb
  
  Volume: 18(4) Pages: 312-317
- NAID
  130004845370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590250
[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.2011
- Author(s)
  Daigo Homma, Chiho Sumi-Ichinose, Hirofumi Tokuoka, Kazuhisa Ikemoto, Takahide Nomura, Kazunao Kondo, Setsuko Katoh, and Hiroshi Ichinose.
- Journal Title
  
  J Biol Chem
  
  Volume: 286(2) Pages: 1445-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590250
[Journal Article] Regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.2010
- Author(s)
  Chiho Sumi-Ichinose, Hiroshi Ichinose, Kazuhisa Ikemoto, Takahide Nomura, and Kazunao Kondo.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 114 Pages: 17-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Sepiapterin reductase gene disrupted mice suffered from severe priapism.2019
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, Hiroshi Ichinose and Kazunao Kondo
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] Effect of methotrexate on pteridine-contents and relaxation response of the aorta from quinonoid-dihydropteridine reductase (QDPR) knockout mice.2018
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, Ichinose Hiroshi, and Kazunao Kondo
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] テトラヒドロビオプテリン欠損マウスは、重篤な持続勃起症を発症する2018
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、近藤一直
- Organizer
  第134回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスの血圧変動の機序2017
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第131回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] メトトレキサート投与が、キノノイド型ジヒドロビオプテリン還元酵素遺伝子ノックアウトマウス大動脈のプテリジン含量と弛緩反応におよぼす影響2017
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、一瀬　宏、近藤一直
- Organizer
  第31回日本プテリジン研究会
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] Sepiapterin reductase gene disrupted mice suffered from hypertension with fluctuation and bradycardia.2017
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Hiroko Nomura, Kazuhisa Ikemoto, Tadayoshi Hata, Setsuko Katoh, Hiroshi Ichinose and Kazunao Kondo
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール(長崎県・長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] ビオプテリン欠損がひきおこす不安定な高血圧・徐脈とPriapism（持続勃起症）2016
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第135回日本薬理学会関東部会
- Place of Presentation
  アクトシティ浜松交流センター(静岡県・浜松市)
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスの加齢と循環器系フェノタイプの変化2016
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第130回日本薬理学会近畿部会
- Place of Presentation
  京都大学百周年時計記念館(京都府・京都市）
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] セピアプテリン還元酵素遺伝子ノックアウトマウスは変動の大きい高血圧、徐脈とpriapism（持続勃起症）を生じる2016
- Author(s)
  一瀬（鷲見）千穂、菅沼由唯、狩野泰輝、井平典子、野村裕子、池本和久、畑　忠善、加藤節子、一瀬　宏、近藤一直
- Organizer
  第30回日本プテリジン研究会
- Place of Presentation
  名古屋大学環境学研究科環境総合館レクチャーホール１Ｆ(愛知県・名古屋市）
- Data Source
  KAKENHI-PROJECT-16K08561
[Presentation] Sepiapterin reductase knockout mice suffered from unstable hypertension and serious priapism.2016
- Author(s)
  ①Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, and Kazunao Kondo.
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜　パシフィコ横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25460346
[Presentation] キノノイド型ジヒドロプテリン還元酵素遺伝子ノックアウトマウス大動脈リング標本の血管弛緩反応2015
- Author(s)
  ③一瀬―鷲見千穂、菅沼由唯、狩野泰輝、井平典子、池本和久、一瀬　宏、近藤一直
- Organizer
  第29回日本プテリジン研究会
- Place of Presentation
  多摩　日本医科大学多摩永山病院会議室
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460346
[Presentation] Hypoxiaが血管内皮細胞における細胞内テトラヒドロビオプテリン量と細胞増殖に及ぼす影響2015
- Author(s)
  ②池本和久、菅沼由唯、狩野泰輝、野村隆英、一瀬千穂、近藤一直
- Organizer
  第29回日本プテリジン研究会
- Place of Presentation
  多摩　日本医科大学多摩永山病院会議室
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460346
[Presentation] マウス全血におけるテトラヒドロビオプテリンの抗血小板作用2013
- Author(s)
  菅沼由唯、池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] マウス血小板凝集にテトラヒドロビオプテリンが及ぼす影響2012
- Author(s)
  菅沼由唯、池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第22回循環器薬理学会年会
- Place of Presentation
  富山
- Year and Date
  2012-11-30
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] シンポジウム 1 ビタミン研究の最前線2012
- Author(s)
  一瀬宏、本間大悟、一瀬(鷲見)千穂、近藤一直
- Organizer
  ビオプテリンによる脳内ドーパミン系の発達および神経機能との関連第10回日本機能性食品医用学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] テトラヒドロビオプテリンがマウス血小板凝集に及ぼす影響2012
- Author(s)
  菅沼由唯、池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第121回日本薬理学会近畿部会
- Place of Presentation
  徳島
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Characterization of dihydropteridine reductase knockout mice15th2012
- Author(s)
  Hiroshi Ichinose, Sho Sanechika, Yoshitaka Hara, Yusuke Sudo, Feng Xu, Shun-ichiro Honda, Sho Shimaguchi, Shigeki Matsuki, Mieko Horiguchi, MasayoKojima, Takahide Nomura, Kazunao Kondo, Chiho Sumi-Ichinose.
- Organizer
  International Symposium onPteridines and Folates
- Place of Presentation
  Antalya Turkey
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] テトラヒドロビオプテリンの欠乏はモノアミン神経系の生後発達を阻害する2012
- Author(s)
  一瀬(鷲見)千穂、菅沼由唯、池本和久、野村隆英、近藤一直
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] テトラヒドロビオプテリンによる血小板凝集抑制効果のメカニズム解明2012
- Author(s)
  菅沼由唯、池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第122回日本薬理学会近畿部会
- Place of Presentation
  豊中
- Year and Date
  2012-11-16
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] チロシン水酸化酵素の転写促進因子 V-1 はドーパ脱炭酸酵素の遺伝子発現を増強する2012
- Author(s)
  来延新、川畑伊知郎、一瀬千穂、近藤一直、加藤成樹、一瀬宏、小林和人、山國徹
- Organizer
  第51回日本薬学会東北支部大会
- Place of Presentation
  青森
- Year and Date
  2012-10-07
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Disturbance in the biosynthesis of monoamines andPTSD-like phenotype in the dihydrpterinr reductase-deficient mice.2012
- Author(s)
  Hiroshi Ichinose, Yusuke Sudo, ShoSanechika, Koichi Tanda, Kenzo Takao, Yoshitaka Hara, Shun-ichiro Honda, Sho Shimaguchi, Masayo Kojima, ChihoSumi-Ichinose, Takahide Nomura, KazunaoKondo, Tsuyoshi Miyakawa
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system2011
- Author(s)
  D. Homma, C. Sumi-Ichinose, H. Tokuoka, K. Ikemoto, T. Nomura, K. Kondo, H. Ichinose
- Organizer
  10th International Conference on Alzheimer's and Parkinson's Diseases
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Tetrahydrobiopterin and reactive oxygen species in cutokine-stimulated HUVEC2011
- Author(s)
  K. Ikemoto, C. Sumi-Ichinose, T. Nomura, K. Kondo
- Organizer
  Gordon Research Conference, Vascular Cell Biology
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Neuronal activity of the basal ganglia in a transgenic mouse model of dopa-responsive dystonia.2011
- Author(s)
  Satomi Chiken, Chiho Sumi-Ichinose, Hiroshi Ichinose, Kazunao Kondo, Atsushi Nambu
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] 統合失調症様行動異常を呈する APC1638T マウスの脳におけるモノアミンの動態2010
- Author(s)
  千田隆夫、尾之内高慶、唐沢延幸、一瀬千穂、高雄啓三、近藤一直、宮川剛
- Organizer
  日本解剖学会第70回中部支部学術集会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] テトラヒドロビオプテリン欠損マウスの生後発達と生化学的変化2010
- Author(s)
  一瀬(鷲見)千穂、池本和久、野村隆英、近藤一直
- Organizer
  第118回日本薬理学会近畿部会
- Place of Presentation
  大阪
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] プテリン類の分析に関する 3 項目の検討2010
- Author(s)
  池本和久、一瀬千穂、野村隆英、近藤一直
- Organizer
  第24回日本プテリジン研究会シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-22590250
[Presentation] Aortic relaxation by acethlcholine is maintained against hyper dihydrobiopterinemia in quinonoid-dihydrobiopterin reductase knockout mice
- Author(s)
  Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Kazuhisa Ikemoto, Takahide Nomura, and Kazunao Kondo
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  Naggoya, Japan
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25460346

1. SUMI-ICHINOSE Chiho (10247653)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
2. Ichinose Hiroshi (90192492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. Ihira Noriko

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. UMEMURA Kazuo (40232912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IKEDA Yasuhiko (50293618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAKAMURA Mieko (30236012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KANAMORI Masao (90127019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kondo Kazunao 近藤 一直

KONDO Kazunao 近藤 一直

Research Projects

Research Products

Co-Researchers

Tetrahydrobiopterin-deficiency causes hypertension with fluctuation, bradycardia and priapism.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the disease induced by imbalance of tetrahydrobiopterin-metabolism and research on the mechanisms for protection against the state.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Origin of neointima cells and mechanism of intima thickening formation, using radiation chimera rat.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of osteopontin in diabetic atherosclerosiPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヘパリン結合性増殖因子ミッドカインが血管内膜肥厚におよぼす影響Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pharmacological investigation of roles of cyclic flow reductions in the development of cerebral infarction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.2017

Author(s)

Journal Title

Data Source

[Journal Article] Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cilostazol Inhibits Cytokine-induced Tetrahydrobiopterin Biosynthesis in Human Umbilical Vein Endothelial Cells.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.2011

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.2010

Author(s)

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[Presentation] Sepiapterin reductase gene disrupted mice suffered from severe priapism.2019

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[Presentation] Effect of methotrexate on pteridine-contents and relaxation response of the aorta from quinonoid-dihydropteridine reductase (QDPR) knockout mice.2018

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[Presentation] テトラヒドロビオプテリン欠損マウスは、重篤な持続勃起症を発症する2018

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Kondo Kazunao 近藤一直

KONDO Kazunao 近藤一直

[Presentation] マウス全血におけるテトラヒドロビオプテリンの抗血小板作用2013