MATSUMOTO Shigekiyo 松本重清

Researcher Number	90274761
Other IDs
Affiliation (Current)	2022: 大分大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2011 – 2022: 大分大学, 医学部, 准教授 2010: 大分大学, 医学部, 講師 2008 – 2009: 大分大学, 医学部, 助教 2005: 大分大学, 医学部, 助手 2004: 大分大学, 脳・神経機能統御講座, 助手 2003: Oita University, Faculty of Medicine, Assistant Professor, 医学部, 助手 2002: 大分医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology / Basic Section 55050:Anesthesiology-related Except Principal Investigator Basic Section 55050:Anesthesiology-related / Basic Section 55060:Emergency medicine-related / Anesthesiology / Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 酸化ストレス / ビタミンC / アスコルビン酸 / 敗血症 / 電子スピン共鳴 / フリーラジカル / 脳虚血 / 弓部大動脈置換術 / 脳分離体外循環 / アスコルビン酸ラジカル … More / 電子スピン共鳴法 / ヒドロキシルラジカル / 副腎不全 / ETS-GS / ビタミン / 下垂体後葉ホルモン / 副腎髄質ホルモン / 副腎皮質ホルモン / カテコラミン / コルチゾール / SMP30/GNLノックアウトマウス / 敗血症性ショック / 下垂体ホルモン / 副腎皮質・髄質ホルモン / 下垂体・副腎ホルモン / 副腎機能 / 術後せん妄 / 全身性炎症反応 / 炎症反応 / 周術期せん妄 / 術後認知機能障害 / 抗酸化療法 / 揮発性有機化合物 / 術中バイオマーカー / 急性腎傷害 / 臓器傷害 / 術後合併症 / 呼気モニタリング / 周術期臓器傷害 / 炎症 … More Except Principal Investigator フリーラジカル / 電子スピン共鳴 / 抗酸化作用 / ラジカル消去能 / 酸化ストレス / RT-PCR / 局所麻酔薬 / 電子スピン共鳴法 / 質量分析イメージング / 抗酸化能 / スピン共鳴解析 / 核磁気共鳴法 / ビタミンC / 周術期合併症 / 全脳虚血 / 脳低体温療法 / 気腹 / 循環動態 / ADH / Pnumoperitoneum / hemodynamics / local anesthetics / フリーラジカル消去作用 / 水溶性αリポ酸誘導体 / 高エネルギーリン酸 / NMRメタボロミクス / フリーラジカル消去能 / Dexmedetomidine / 虚血再灌流傷害 / スピン解析 / 虚血-再灌流負荷 / 脳エネルギー代謝 / レミフェンタニル / ラジカル消去作用 / remifentanil / 術後認知機能障害 / μオピオイド受容体作動薬 / VCR/DMSO / 外傷 / 電子スピン共鳴装置 / ラジカル / 補充療法 / 敗血症 / 光療法 / 概日リズム / 認知機能障害 / 認知機能傷害 / スピンメタボロミクス / NMR / ESR / 局所麻酔 / 抗酸化 / 酸化増強 / 心停止後症候群 / 治療介入 / 心停止 / 抗酸化物質 / レミマゾラム Less

Anti-oxidative activity of Remimazolam
- Principal Investigator
  
  徳丸治
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Oita University
Light elicited circadian re-entrainment as a treatment for post-sepsis cognitive impairment
- Principal Investigator
  
  小山淑正
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Oita University
周術期合併症に関する予測因子の基礎的検討-スピンメタボロミクスの臨床応用
- Principal Investigator
  
  新宮千尋
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Oita University
Real-time monitoring of breath volatile organic compounds for early detection of perioperative organ injuryPrincipal Investigator
- Principal Investigator
  
  松本重清
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Oita University
Are local anesthetics antioxidants or prooxidants?
- Principal Investigator
  
  北野敬明
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Oita University
Assessment of oxidative stress and therapeutic intervention in cases of cardiac arrest and Post-Cardiac Arrest Syndrome
- Principal Investigator
  
  重光修
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Oita University
Antioxidative activity of remifentanil: Does remifentanil directly scavenge free radicals?
- Principal Investigator
  
  徳丸治
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Oita University
Establishment of additional Vitamin C therapy for the suppression of oxidative stress from patients with severe traumatic injury
- Principal Investigator
  
  竹中隆一
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Oita University
Antioxidative effect of dexmedetomidine by spin resonance analysis
- Principal Investigator
  
  Kitano Takaaki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Oita University
Antioxidative therapy for prevention of postoperative delirium and cognitive dysfunctionPrincipal Investigator
- Principal Investigator
  
  Matsumoto Shigekiyo
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Oita University
Antioxidative and neuroprotective activity of alpha-lipoic acid derivatives: spin resonance analyses
- Principal Investigator
  
  Tokumaru Osamu
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Oita University
A new endocrinological mechanism of septic shock and vitamin C supplementation in septic shock under real-time vitamin C monitoring with electron spin resonance spectroscopyPrincipal Investigator
- Principal Investigator
  
  Matsumoto Shigekiyo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Oita University
A new strategy for adrenal insufficiency in septic shock: a new antioxdant ETS-GSPrincipal Investigator
- Principal Investigator
  
  MATSUMOTO Shigekiyo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Oita University
Assessing the severity of patients in therapeutic hypothermia for brain -ESR study-
- Principal Investigator
  
  SHINGU Chihiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Oita University
血中フリーラジカルの経時的変化による脳虚血の検出:電子スピン共鳴法を用いた検討Principal Investigator
- Principal Investigator
  
  松本重清
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Oita University
  大分医科大学
Effect of. local anesthetics on cerebral and abdominal organ injury during pneumoperitoneum
- Principal Investigator
  
  YOSHITAKE Shigenori
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Oita University (Faculty of Medicine)

All 2022 2021 2020 2019 2017 2016 2010

All Journal Article Presentation

[Journal Article] Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors2019
- Author(s)
  Umeda Ryohei、Takanari Hiroki、Ogata Kazue、Matsumoto Shigekiyo、Kitano Takaaki、Ono Katsushige、Tokumaru Osamu
- Journal Title
  
  J. Clin. Biochem. Nutr.
  
  Volume: 64 Issue: 1 Pages: 20-26
- DOI
  10.3164/jcbn.18-48
- NAID
  130007542260
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11087, KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-15K10515, KAKENHI-PROJECT-16K09964, KAKENHI-PROJECT-19H04443
[Journal Article] The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury : an electron spin study.2010
- Author(s)
  Matsumoto S, Shingu C, Koga H, Hidaka S, Goto K, Hagiwara S, Iwasaka H, Noguchi T, Yokoi I.
- Journal Title
  
  Journal of Trauma 68
  
  Pages: 796-801
- Data Source
  KAKENHI-PROJECT-20591808
[Journal Article] An Electron Spin Resonance Study for Real-time Detection of Ascorbyl Free Radicals After Addition of Dimethyl Sulfoxide in Murine Hippocampus or Plasma During Kainic Acid-Induced Seizures.2010
- Author(s)
  Matsumoto S, Shingu C, Koga H, Hagiwara S, Iwasaka H, Noguchi T, Yokoi I.
- Journal Title
  
  Neurochem Res. 35(7)
  
  Pages: 1010-1016
- Data Source
  KAKENHI-PROJECT-20591808
[Journal Article] The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury : an electron spin resonance study2010
- Author(s)
  Matsumoto S, Shingu C, Koga H, Hidaka S, Goto K, Hagiwara S, Iwasaka H, Noguchi T, Yokoi I.
- Journal Title
  
  Journal of Trauma 68
  
  Pages: 796-801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591808
[Journal Article] An Electron Spin Resonance Study for Real-time Detection of Ascorbyl Free Radicals After Addition of Dimethyl Sulfoxide in Murine Hippocampus or Plasma During Kainic Acid-Induced Seizures2010
- Author(s)
  Matsumoto S, Shingu C, Koga H, Hagiwara S, Iwasaka H, Noguchi T, Yokoi I
- Journal Title
  
  Neurochemical Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591808
[Presentation] 待機的心臓・大血管手術における術後譫妄と炎症および酸化ストレスの関連ー新規予防戦略の提案ー2022
- Author(s)
  栗林由英，松本重清，小山淑正，日高正剛，新宮千尋，北野敬明
- Organizer
  日本麻酔科学会第69回学術集会
- Data Source
  KAKENHI-PROJECT-17K11088
[Presentation] 待機的心臓・大血管手術における高齢者術後譫妄には酸化ストレスが関与するー電子スピン共鳴(ESR)装置を用いた検討ー2021
- Author(s)
  栗林由英、松本重清、小山淑正、北野敬明
- Organizer
  第33回日本老年麻酔学会
- Data Source
  KAKENHI-PROJECT-17K11088
[Presentation] Antioxidative activity of ketamineas a direct radical scavenger2021
- Author(s)
  Tokumaru O, Ozaki Y, Kawano T, Ogata K, Eshima N, Matsumoto S, Kitano T
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K09329
[Presentation] 心臓・大血管疾患に対する待機的手術における術後譫妄とビタミンCの関連ー電子スピン共鳴装置を用いた検討ー2021
- Author(s)
  栗林由英、松本重清、小山淑正、新宮千尋、尾方和枝、北野敬明
- Organizer
  日本麻酔科学会第68回学術集会
- Data Source
  KAKENHI-PROJECT-17K11088
[Presentation] Serum Vitamin C Levels were decreased in Severe Emergency Patients2020
- Author(s)
  ①Ryuichi Takenaka、Nureki Shinichi、Kiyoshige Matsumoto、Osamu Shigemitsu
- Organizer
  40th ISICEM（国際救急集中治療会議）/Web発表
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09290
[Presentation] 電子スピン共鳴法によるデクスメデトミジンのフリーラジカル消去能の検討2019
- Author(s)
  西田太一, 徳丸治, 松本重清, 内野哲哉, 新宮千尋, 北野敬明
- Organizer
  日本麻酔科学会
- Data Source
  KAKENHI-PROJECT-17K11087
[Presentation] Antioxidative activity of dexmedetomidine as a direct free radical scavenger2019
- Author(s)
  Kazue O, Yoshida K, Matsumoto S, Shingu C, Kitano T, Tokumaru O
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K11087
[Presentation] Direct observation of ascorbyl free radicals (vitamin C radicals) in blood of perioperative animals2017
- Author(s)
  Osamu Tokumaru, Shigekiyo Matsumoto, Takayuki Mizoguchi, Takayuki Kawashima, Kazue Ogata, Shinji Miyamoto, Takaaki Kitano
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K11087
[Presentation] Direct observation of ascorbyl free radicals (vitamin C radicals) in blood of perioperative animals2017
- Author(s)
  Osamu Tokumaru, Shigekiyo Matsumoto, Takayuki Mizoguchi, Takayuki Kawashima, Kazue Ogata, Shinji Miyamoto, Takaaki Kitano
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15K10515
[Presentation] 周術期の血液から検出されるアスコルビン酸フリーラジカルについて2016
- Author(s)
  徳丸治，松本重清，岡本啓太郎，溝口貴之，尾方和枝．北野敬明
- Organizer
  第69回日本酸化ストレス学会学術集会
- Place of Presentation
  仙台国際センター会議棟（宮城県・仙台市）
- Year and Date
  2016-08-30
- Data Source
  KAKENHI-PROJECT-15K10515

1. Tokumaru Osamu (40360151)

# of Collaborated Projects: 7 results

# of Collaborated Products: 7 results
2. SHINGU Chihiro (30295191)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
3. Kitano Takaaki (20211196)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
4. 江島伸興 (20203630)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 竹中隆一 (90457606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 重光修 (40215968)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. YOKOI Isao (80150366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. NOGUCHI Takayuki (90156183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. YOSHITAKE Shigenori (10200974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 西田育弘 (90172668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小山淑正 (40468012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 穴井博文 (20291544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 李丞祐 (60326460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOGA Hironori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ISHIGAMI Akihito

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 高成広起

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 緒方藍歌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUMOTO Shigekiyo 松本 重清

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Antioxidative therapy for prevention of postoperative delirium and cognitive dysfunctionPrincipal Investigator

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A new endocrinological mechanism of septic shock and vitamin C supplementation in septic shock under real-time vitamin C monitoring with electron spin resonance spectroscopyPrincipal Investigator

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A new strategy for adrenal insufficiency in septic shock: a new antioxdant ETS-GSPrincipal Investigator

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血中フリーラジカルの経時的変化による脳虚血の検出:電子スピン共鳴法を用いた検討Principal Investigator

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MATSUMOTO Shigekiyo 松本重清