Shiokawa Daisuke 塩川大介

… Alternative Names

塩川大介シオカワダイスケ

DAISUKE Shiokaswa 塩川大介

SHIOKAWA Daisuke 塩川大介

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Researcher Number	90277278
Other IDs
Affiliation (Current)	2025: 愛媛大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2023: 愛媛大学, 医学部附属病院, 講師 2022: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2018 – 2020: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2015: 国立研究開発法人国立がん研究センター, がん分化制御解析分野, ユニット長 2015: 国立研究開発法人国立がん研究センター, その他部局等, ユニット長 … More 2014: 独立行政法人国立がん研究センター, がん分化制御解析分野, ユニット長 1998 – 2006: 東京理科大学, 薬学部, 助手 1996: Science University of Tokyo, Assistant Professor, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / 細胞死(アポトーシス) / Experimental pathology / Biological pharmacy / Molecular biology Except Principal Investigator Biological Sciences / Biological pharmacy / Cell biology
Keywords	Principal Investigator シングルセル / 大腸がん / Wntシグナル / 遺伝子発現解析 / apoptosis / エンドヌクレアーゼ / DNase / アポトーシス / 共培養 / がん微小環境 … More / 浸潤先端細胞 / がん転移 / 細胞不均一性 / 細胞多様性 / がん幹細胞 / neuron / endonuclease / expression / gene / differentiation / 転写調節 / 神経 / 遺伝子発現 / 細胞分化 / translation initiation / GPI-anchor / interferon / phagocytosis / macrophage / 細胞死 / DNase γ / GFP / 核移行シグナル / 細胞内局在 … More Except Principal Investigator アポトーシス / DNaseγ / DNase γ / class switch / apoptosis / クラススイッチ / クローナルデリーション / ネガティブセレクション / ノックアウトマウス / DNase gamma / 胸腺細胞 / モノクローナル抗体 / DNA断片化 / DNA修復 / self antigen / disease / autoimmune / knockout mice / 自己抗体 / 自己免疫疾患 / clonal deletion / negative selection / knockout mouse / 相同組換え / ES細胞 / DNase_γ / cell death / DNA endonuclease / DNA fragmentation / apoptpsis / プログラム細胞死 / ヌクレオソーム / DNA分断化 / ネクローシス / 細胞死 / エンドヌクレアーゼ / 細胞縮小 / ドラッグデザイン / カスパーゼ / Smac / IAP / がん / B細胞 / Caspase / 細胞増殖 / 細胞分化 / ヒト卵巣癌細胞 / 制癌剤 / X線 / 核移行シグナル / ポリ(ADP-リボシル)化 Less

がん微小環境が造り出す浸潤転移性がん細胞発生メカニズムの解明Principal Investigator
- Principal Investigator
  
  塩川大介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Ehime University
  National Cancer Center Japan
Single-cell gene expression analysis reveals the cellular heterogeneity of colon tumors and identifies novel therapeutic target genesPrincipal Investigator
- Principal Investigator
  
  Shiokawa Daisuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Characterization of cellular heterogeneity of colon tumors by gene expression analyses at the single cell levelPrincipal Investigator
- Principal Investigator
  
  Shiokawa Daisuke
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  National Cancer Center Japan
XIAP阻害Smac-mimetic分子設計による制がんリード化合物の創製
- Principal Investigator
  
  田沼靖一
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Science
マクロファージの貧食/アポトーシスにおけるDNA分解機構の解明Principal Investigator
- Principal Investigator
  
  塩川大介
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Science
真核細胞の分化/アポトーシス経路切り換え機構の解明
- Principal Investigator
  
  田沼靖一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Science
Involvement of DNase g during apoptosis associated with myogenic differentiationPrincipal Investigator
- Principal Investigator
  
  SHIOKAWA Daisuke
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  細胞死(アポトーシス)
- Research Institution
  TOKYO UNIVERSITY OF SCIENCE
Apoptosis in DNase g deficient mic
- Principal Investigator
  
  TANUMA Seiichi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  TOKYO UNIVERSITY OF SCIENCE
アポトーシス・DNaseγを標的としたがん診断法の開発
- Principal Investigator
  
  田沼靖一
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Science
アポトーシス、DNaseγを指標としたがん診断法の開発
- Principal Investigator
  
  田沼靖一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Science
Analysis ofApoptosis Mechanisms in DNase y-deficient Mice
- Principal Investigator
  
  SEI-ICHI Tanuma
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Science University of Tokyo
哺乳類細胞のDNA修復とアポトーシスの経路選択機構
- Principal Investigator
  
  田沼靖一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Science
アポトーシスを司るエンドヌクレアーゼ、DNase_γの活性制御機構Principal Investigator
- Principal Investigator
  
  塩川大介
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Tokyo University of Science
哺乳類細胞のDNA修復とアポトーシスの経路選択機構
- Principal Investigator
  
  TANUMA Sei-ichi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Science
Molecular mechanisms and function of apoptosis Faculty of Pharmaceutical Science
- Principal Investigator
  
  TANUMA Sei-ichi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Science University of Tokyo

All 2023 2022 2019 2018 2015 2007 2006 2005 2004 Other

All Journal Article Presentation Book Other

[Book] 阻害剤・活性化剤ハンドブック　（秋山徹、河府和義　編）2019
- Author(s)
  塩川大介
- Total Pages
  646
- Publisher
  羊土社
- ISBN
  9784758120999
- Data Source
  KAKENHI-PROJECT-18K07283
[Journal Article] PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway2023
- Author(s)
  Ohata Hirokazu、Shiokawa Daisuke、Sakai Hiroaki、Kanda Yusuke、Okimoto Yoshie、Kaneko Syuzo、Hamamoto Ryuji、Nakagama Hitoshi、Okamoto Koji
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 6 Pages: 112519-112519
- DOI
  10.1016/j.celrep.2023.112519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07037, KAKENHI-PROJECT-23K07467, KAKENHI-PROJECT-21H03081, KAKENHI-PROJECT-21H03550
[Journal Article] DNase X is a GPI-anchored membrane enzyme that provides a barrier to endocytosis-mediated transfer of a foreign gene2007
- Author(s)
  Shiokawa D. et al.
- Journal Title
  
  J Biol Chem (In press)
- Data Source
  KAKENHI-PROJECT-17790075
[Journal Article] Stage-specific expression of DNasegamma during B-cell development and its role in B-cell receptor-mediated apoptosis in WEHI-231 cells2007
- Author(s)
  Shiokawa D. et al.
- Journal Title
  
  Cell Death Differ 14
  
  Pages: 992-1000
- Data Source
  KAKENHI-PROJECT-17790075
[Journal Article] cDNA cloning and functional characterization of Xenopus laevis DNase gamma.2006
- Author(s)
  Shiokawa, D. et al.
- Journal Title
  
  Apoptosis In press
- Data Source
  KAKENHI-PROJECT-17790075
[Journal Article] cDNA cloning and functional characterization of Xenopus laevis DNase gamma2006
- Author(s)
  Shiokawa D. et al.
- Journal Title
  
  Apoptosis 11
  
  Pages: 555-562
- Data Source
  KAKENHI-PROJECT-17790075
[Journal Article] Physical and biochemical properties of mammalian DNase X proteins : non-AUG translation initiation of porcine and bovine mRNAs for DNase X2005
- Author(s)
  Shiokawa, D. et al.
- Journal Title
  
  Biochem J 329
  
  Pages: 511-517
- Data Source
  KAKENHI-PROJECT-17790075
[Journal Article] Involvement of DNase gamma in the resected double-strand DNA breaks in immunogbulin genes.2005
- Author(s)
  Daisuke Shiokawa
- Journal Title
  
  Biochem Biophys Res Commun. 327
  
  Pages: 76-83
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15603006
[Journal Article] Characterization of the human DNAS1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines.2004
- Author(s)
  Daisuke Shiokawa
- Journal Title
  
  Genomics. 84
  
  Pages: 95-105
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15603006
[Journal Article] A novel inhibitor that protects apoptotic DNA fragmentation catalyzed by DNase gamma.2004
- Author(s)
  Daisuke Shiokawa
- Journal Title
  
  Biochem Biophys Res Commun. 325
  
  Pages: 1292-1297
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15603006
[Journal Article] Differential DNases are selectively used in neuronal apoptosis depending on the differentiation state.2004
- Author(s)
  Daisuke Shiokawa
- Journal Title
  
  Cell Death Differ. 11
  
  Pages: 1112-1120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15603006
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes.2004
- Author(s)
  Daisuke Shiokawa
- Journal Title
  
  Cell Tissue Res. 316
  
  Pages: 403-407
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15603006
[Journal Article] Characterization of the human DNA S1L2 gene and the molecular mechanism for its transcriptional activation induced by inflammatory cytokines.2004
- Author(s)
  Daisuke Shiokawa
- Journal Title
  
  Genomics. 84
  
  Pages: 95-105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15603006
[Journal Article] Aging increases DNase gamma, an apoptosis-related endonuclease, in rat liver nuclei : effect of dietary restriction.2004
- Author(s)
  Daisuke Shiokawa
- Journal Title
  
  Exp Gerontol. 39
  
  Pages: 195-202
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15603006
[Presentation] 肝臓がんにおけるPHLDA familyの機能解析2023
- Author(s)
  小林直矢、青木清乃、チンヨ、山本雅大、塩川大介、大木理恵子
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K07037
[Presentation] Development of colon cancer invasion front cells via interaction with tumor microenvironment2023
- Author(s)
  Daisuke Shiokawa, Hirokazu Ohata, and Koji Okamoto
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-22K07037
[Presentation] Reverse-Phase Protein Array for Proteo-Epigenomic Profiling of Colorectal Cancer Patient-Derived Organoids2023
- Author(s)
  Shota Takeda, Daisuke Shiokawa, Toru Aoyama, Kenichi Yoshioka, Koji Okamoto, Mari Masuda
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-22K07037
[Presentation] Elucidation of chemoresistant niches of ovarian clear cell carcinoma via single-cell analyses & spatial transcriptomics2022
- Author(s)
  森裕太郎、神田裕介、石黒竜也、吉原弘祐、山脇芳、大畑広和、塩川大介、榎本隆之、岡本康司
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07037
[Presentation] FXYD3, a subunit of Na+K+ pump, determines the root of triple-negative breast cancer stem-like cells2022
- Author(s)
  李梦嬌、西村建徳、塩川大介、矢野正雄、石川聡子、太田哲生、田辺真彦、多田敬一郎、秋山徹、島村徹平、佐藤慎哉、宮城洋平、鈴木穣、岡本康司、東條有伸、後藤典子
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07037
[Presentation] A gene expression signature in slow-cycling colon cancer stem cells: Implications for cancer progression and chemoresistance2022
- Author(s)
  DAISUKE SHIOKAWA, HIROAKI SAKAI, HIROKAZU OHATA, YUSUKE KANDA, HITOSHI NAKAGAMA, KOJI OKAMOTO
- Organizer
  12th AACR-JCA Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07037
[Presentation] PROX1 induction by autophagy provide a persister-like state via repression of NOX1-mTORC1 pathway in colon cancer cells2022
- Author(s)
  大畑広和、塩川大介、岡本康司
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07037
[Presentation] Transcriptional factor Tcf1 controls the drug resistance of Lgr5-positive colon tumor stem cells2019
- Author(s)
  Daisuke Shiokawa, Hirokazu Ohata, Koji Okamoto
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18K07283
[Presentation] The slow-growing sub-population of Lgr5-positive colon tumor stem cells is resistant to an anti-cancer drug treatment2018
- Author(s)
  Daisuke Shiokawa
- Organizer
  日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07283
[Presentation] Heterogeneity of Lgr5-positive colon tumor stem cells demonstrated by single-cell qPCR2015
- Author(s)
  Daisuke Shiokawa, Hirokazu Ohata, Koji Okamoto
- Organizer
  日本癌学会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26670195
[Presentation] Dynamic regulation of colon tumor-derived stem cells demonstrated by single-cell qPCR2015
- Author(s)
  Daisuke Shiokawa, Hirokazu Ohata, Koji Okamoto
- Organizer
  幹細胞シンポジウム
- Place of Presentation
  東京大学伊藤国際学術研究センターB2F 伊藤謝恩ホール
- Year and Date
  2015-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670195
[Presentation] ROS enhances stemness by activating mTOR pathway in colorectal cancer stem cells
- Author(s)
  Hirokazu Ohata, Daisuke Shiokawa, Hitoshi Nakagama, Koji Okamoto
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26670195
[Presentation] Altered expression of a subset of Wnt target genes in colon tumor-derived stem cells demonstrated by single-cell qPCR
- Author(s)
  Daisuke Shiokawa, Masako Ochiai, Hitoshi Nakagama, Koji Okamoto
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26670195
[Presentation] nterleukin-22 disrupts cell polarity and barrier function in the 3D cultured intestinal epithelial cell
- Author(s)
  Yoshinori Ikarashi, Junya Asahira, Takuya Matsuyama, Daisuke Shiokawa, Kazuhiro Kato, Toshio Imai, Hitoshi Nakagama, and Koji Okamoto
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26670195
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1. TANUMA Sei-ichi (10142449)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. MARUTA Hideharu (00266917)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 青木一正 (10184029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 内海文彰 (00256679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shiokawa Daisuke 塩川 大介

塩川 大介 シオカワ ダイスケ

DAISUKE Shiokaswa 塩川 大介

SHIOKAWA Daisuke 塩川 大介

Research Projects

Research Products

Co-Researchers

がん微小環境が造り出す浸潤転移性がん細胞発生メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single-cell gene expression analysis reveals the cellular heterogeneity of colon tumors and identifies novel therapeutic target genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of cellular heterogeneity of colon tumors by gene expression analyses at the single cell levelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マクロファージの貧食/アポトーシスにおけるDNA分解機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Involvement of DNase g during apoptosis associated with myogenic differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

アポトーシスを司るエンドヌクレアーゼ、DNase_γの活性制御機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Shiokawa Daisuke 塩川大介

塩川大介シオカワダイスケ

DAISUKE Shiokaswa 塩川大介

SHIOKAWA Daisuke 塩川大介

[Book] 阻害剤・活性化剤ハンドブック　（秋山徹、河府和義　編）2019