Sakai Nobuhiro 坂井信裕

… Alternative Names

SAKAI Nobuhiro 坂井信裕

坂井信宏サカイノブヒロ

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Researcher Number	90286849
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 歯学部, 教授
Affiliation (based on the past Project Information) *help	2025: 昭和大学, 歯学部, 教授 2022 – 2023: 昭和大学, 歯学部, 教授 2021: 昭和大学, 歯学部, 准教授 2017 – 2020: 昭和大学, 歯学部, 講師 2007: Showa University, Sch. of Dent., Assistant Professor 2001 – 2006: 昭和大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 62030:Learning support system-related / Basic Section 57030:Conservative dentistry-related / Periodontology Except Principal Investigator Functional basic dentistry / Functional basic dentistry
Keywords	Principal Investigator 象牙質 / 破骨細胞 / 骨代謝 / 脂質代謝 / 歯質形成 / 歯 / 骨恒常性 / 骨 / 薬理学 / 再生医学 / 歯学 / 骨芽細胞 / 骨密度 … More Except Principal Investigator … More osteoclast / CD44 / CSF-1 / 破骨細胞 / 細胞骨格 / オステオポンティン / Flt-1 / VEGF / Na^+ / RT-PCR / 骨芽細胞 / confocal laser-scanning microscopy / epithelial-mesenchymal transition / cell migration / tumor cell invasion / squamous cell carcinoma / cell fusion / intracellular osteopontin / 細胞骨格再構築 / OsteoPontin / 生細胞 / バイオイメージング / レーザー共焦点顕微鏡 / 上皮間葉転換 / Osteopontin / 細胞浸潤 / 細胞融合 / confocal laser-scannning microscopy / bisphosphonate / - mice / OPN- / bone resorption / Bβ inteerin / osteopontin / OPNノックアウトマウス / β3 integrin / オステオポンチン / 共焦点レーザー顕微鏡 / ビスフォスフォネート / OPN遺伝子欠損マウス / 骨吸収 / β3 インテグリン / アクチン / TRAP / Flk-1 / culture / resorption / 可溶型受容体 / 細胞伸展 / 偽足 / opマウス / op / VEGF受容体1型 / op>マウス / CSF-1^<op / Fcキメラ / VEGF受容体 / キナーゼ活性 / RANKL / NPT2 / Ca^<2+> exchanger / co-culture / resorption pit / osteoblast / mechanical stress / KB-R7943 / Pi輸送体 / Ca^<2+>交換体 / 共存培養 / 吸収窩 / 機械的伸展刺激 Less

歯科教育のためのPC上で医療面接が訓練できるバーチャルCG患者アプリケーションの開発Principal Investigator
- Principal Investigator
  
  坂井信裕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62030:Learning support system-related
- Research Institution
  Showa University
Lipid metabolic functions in tooth and bone homeostasisPrincipal Investigator
- Principal Investigator
  
  Sakai Nobuhiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Showa University
Development of a method for suppressing bone destruction targeting cholesterol acyltransferase.Principal Investigator
- Principal Investigator
  
  Sakai Nobuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Showa University
Role of intracellular osteopontin in the osteoclast fusion and tumor cell invasion
- Principal Investigator
  
  SUZUKI Keiko
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
Investigation on the role of osteopontin and CD44 in the osteoclast development
- Principal Investigator
  
  SUZUKI Keiko
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa University
Effect of VEGF's on osteockast formation and activation
- Principal Investigator
  
  YAMADA Shoji
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa university
Function analysis of Na^+ dependent ion transporters in bone metabolism
- Principal Investigator
  
  AMANO Hitoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Showa university

All 2024 2023 2022 2021 2020 2019 2018 2017 2004 2003

All Journal Article Presentation

[Journal Article] Tacrolimus, FK506, promotes bone formation in bone defect mouse model2024
- Author(s)
  Satoko Nishida, Yuki Azetsu, Masahiro Chatani, Akiko Karakawa, Kai Otake, Hidemitsu Sugiki, Nobuhiro Sakai, Yasubumi Maruoka, Mie Myers, Masamichi Takami
- Journal Title
  
  J Oral Biosci.
  
  Volume: - Issue: 2 Pages: 391-402
- DOI
  10.1016/j.job.2024.02.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06255, KAKENHI-PROJECT-21K10170, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-19KK0233
[Journal Article] Abnormal bone regeneration induced by FK506 in medaka fin revealed by in vivo imaging2024
- Author(s)
  Kai Otake, Yuki Azetsu, Masahiro Chatani, Akiko Karakawa, Satoko Nishida, Aiko Hirayama, Rina Kobayashi, Nobuhiro Sakai, Noriyuki Suzuki, Masamichi Takami
- Journal Title
  
  J Oral Biosci.
  
  Volume: - Issue: 2 Pages: 381-390
- DOI
  10.1016/j.job.2024.02.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06255, KAKENHI-PROJECT-21K10170, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-19KK0233
[Journal Article] Planar catechin increases bone mass by regulating differentiation of osteoclasts in mice2024
- Author(s)
  Daiki Sugawara, Nobuhiro Sakai, Yurie Sato, Yuki Azetsu, Akiko Karakawa, Masahiro Chatani, Mirei Mizuno, Yasubumi Maruoka, Mie Myers, Kiyoshi Fukuhara, Masamichi Takami
- Journal Title
  
  J Oral Biosci.
  
  Volume: - Issue: 1 Pages: 196-204
- DOI
  10.1016/j.job.2024.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06255, KAKENHI-PROJECT-21K10170, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-20K18465
[Journal Article] 歯と骨の恒常性維持における脂質代謝機能の解明2024
- Author(s)
  坂井信裕
- Journal Title
  
  Precision Medicine
  
  Volume: 7(1) Pages: 55-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09963
[Journal Article] Cholesterol and fat in diet disrupt bone and tooth homeostasis in mice2022
- Author(s)
  Sato Yurie、Hosonuma Masahiro、Sugawara Daiki、Azetsu Yuki、Karakawa Akiko、Chatani Masahiro、Funatsu Takahiro、Takami Masamichi、Sakai Nobuhiro
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 156 Pages: 113940-113940
- DOI
  10.1016/j.biopha.2022.113940
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10170, KAKENHI-PROJECT-20K17431, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-20K09963
[Journal Article] Neural crest-derived cells possess differentiation potential to keratinocytes in the process of wound healing2022
- Author(s)
  Takizawa Hideomi、Karakawa Akiko、Suzawa Tetsuo、Chatani Masahiro、Ikeda Megumi、Sakai Nobuhiro、Azetsu Yuki、Takahashi Masahiro、Urano Eri、Kamijo Ryutaro、Maki Koutaro、Takami Masamichi
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 146 Pages: 112593-112593
- DOI
  10.1016/j.biopha.2021.112593
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21687, KAKENHI-PROJECT-19H03820, KAKENHI-PROJECT-21K10170, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-21K06255, KAKENHI-PROJECT-22K09919, KAKENHI-PROJECT-20K18612, KAKENHI-PROJECT-20K09963
[Journal Article] Effects of Anti?Receptor Activator of Nuclear Factor Kappa B Ligand Antibody and Zoledronic Acid on Periapical Lesion Development in Mice2022
- Author(s)
  Ikeda Megumi、Karakawa Akiko、Takizawa Hideomi、Azetsu Yuki、Sakai Nobuhiro、Chatani Masahiro、Suzuki Noriyuki、Takami Masamichi
- Journal Title
  
  Journal of Endodontics
  
  Volume: 48 Issue: 5 Pages: 632-640
- DOI
  10.1016/j.joen.2022.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-21K06255, KAKENHI-PROJECT-21K10170, KAKENHI-PROJECT-21K09877, KAKENHI-PROJECT-20K18465
[Journal Article] Inhibition of hepatocyte growth factor/c-Met signalling abrogates joint destruction by suppressing monocyte migration in rheumatoid arthritis2020
- Author(s)
  Hosonuma Masahiro、Sakai Nobuhiro、Furuya Hidekazu、Kurotaki Yutaro、Sato Yurie、Handa Kazuaki、Dodo Yusuke、Ishikawa Koji、Tsubokura Yumi、Negishi-Koga Takako、Tsuji Mayumi、Kasama Tsuyoshi、Kiuchi Yuji、Takami Masamichi、Isozaki Takeo
- Journal Title
  
  Rheumatology
  
  Volume: 60 Issue: 1 Pages: 408-419
- DOI
  10.1093/rheumatology/keaa310
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-19K18544, KAKENHI-PROJECT-20K17431
[Journal Article] Novel gene Merlot inhibits differentiation and promotes apoptosis of osteoclasts2020
- Author(s)
  Yamakawa Tomoyuki、Okamatsu Nobuaki、Ishikawa Koji、Kiyohara Shuichi、Handa Kazuaki、Hayashi Erika、Sakai Nobuhiro、Karakawa Akiko、Chatani Masahiro、Tsuji Mayumi、Inagaki Katsunori、Kiuchi Yuji、Negishi-Koga Takako、Takami Masamichi
- Journal Title
  
  Bone
  
  Volume: 138 Pages: 115494-115494
- DOI
  10.1016/j.bone.2020.115494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-19K18544, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-18K09866
[Journal Article] Effects of N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice2020
- Author(s)
  Kiyohara S, Sakai N, Handa K, Yamakawa T, Ishikawa K, Chatani M, Karakawa A, Azetsu Y, Munakata M, Ozeki M, Negishi-Koga T, Takami M
- Journal Title
  
  J Oral Biosci
  
  Volume: - Issue: 2 Pages: 131-138
- DOI
  10.1016/j.job.2020.03.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09866, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17J11294, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-19K18544, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-17H04050, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Myelination during fracture healing in vivo in myelin protein zero (p0) transgenic medaka line2020
- Author(s)
  Dodo Y, Chatani M, Azetsu Y, Hosonuma M, Karakawa A, Sakai N, Negishi-Koga T, Tsuji M, Inagaki K, Kiuchi Y, Takami M
- Journal Title
  
  Bone
  
  Volume: 133 Pages: 115225-115225
- DOI
  10.1016/j.bone.2020.115225
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09866, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17J11294, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-20K17431, KAKENHI-PROJECT-20K18465, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-19KK0233, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] Effects of lipid metabolism on mouse incisor dentinogenesis.2020
- Author(s)
  Kurotaki, Y., Sakai, N., Miyazaki, T., Hosonuma, M., Sato, Y., Karakawa, A., Chatani, M., Myers, M., Suzawa, T., Negishi-Koga, T., Kamijo, R., Miyazaki, A., Maruoka, Y., Takami, M.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5102-5102
- DOI
  10.1038/s41598-020-61978-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09511, KAKENHI-PROJECT-18K09866, KAKENHI-PROJECT-19K08590, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-20K09963, KAKENHI-PROJECT-20K20496, KAKENHI-PROJECT-17H04050
[Journal Article] Effects of N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice2020
- Author(s)
  Kiyohara S, Sakai N, Handa K, Yamakawa T, Chatani M, Karakawa A, Azetsua Y, Munakata M, Ozeki M, Negishi-Koga T, Takami M
- Journal Title
  
  J. Oral Biosciences
  
  Volume: S1349-0079(20) Pages: 30046-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11993
[Journal Article] Hypergravity induces vertebrae and otolith deformation in medaka fish2019
- Author(s)
  Chatani M, Mitsuhashi A, Dodo Y, Sakai N, and Takami M
- Journal Title
  
  Biological Sciences in Space
  
  Volume: 33 Issue: 0 Pages: 12-17
- DOI
  10.2187/bss.33.12
- NAID
  130007705239
- ISSN
  0914-9201, 1349-967X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17K11993, KAKENHI-ORGANIZER-15H05935
[Journal Article] Singleton-Merten Syndrome-like Skeletal Abnormalities in Mice with Constitutively Activated MDA52019
- Author(s)
  Soda Nobumasa、Sakai Nobuhiro、Kato Hiroki、Takami Masamichi、Fujita Takashi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 203 Issue: 5 Pages: 1356-1368
- DOI
  10.4049/jimmunol.1900354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11993
[Journal Article] Bone loss caused by dopaminergic degeneration and levodopa treatment in Parkinson’s disease model mice2019
- Author(s)
  Handa Kazuaki、Kiyohara Shuichi、Yamakawa Tomoyuki、Ishikawa Koji、Hosonuma Masahiro、Sakai Nobuhiro、Karakawa Akiko、Chatani Masahiro、Tsuji Mayumi、Inagaki Katsunori、Kiuchi Yuji、Takami Masamichi、Negishi-Koga Takako
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 13768-13768
- DOI
  10.1038/s41598-019-50336-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18544, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-17K18114, KAKENHI-PROJECT-17H04050, KAKENHI-ORGANIZER-15H05935
[Journal Article] Treatment with synthetic glucocorticoid impairs bone metabolism, as revealed by in vivo imaging of osteoblasts and osteoclasts in medaka fish2019
- Author(s)
  Azetsu, Y., Chatani M, Dodo Y, Karakawa A, Sakai N, Negishi-Koga T, Takami M
- Journal Title
  
  Biomed Pharmacother
  
  Volume: 118 Pages: 109101-109101
- DOI
  10.1016/j.biopha.2019.109101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09866, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17J11294, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-17H04050, KAKENHI-ORGANIZER-15H05935
[Journal Article] Biological Effects of Anti-RANKL Antibody and Zoledronic Acid on Growth and Tooth Eruption in Growing Mice2019
- Author(s)
  Isawa M, Karakawa, Sakai N, Nishina S, Kuritani M, Chatani M, Negishi-Koga T, Sato M, Inoue M, Shimada Y, Takami M
- Journal Title
  
  Sci Rep
  
  Volume: 9(1) Issue: 1 Pages: 19895-19895
- DOI
  10.1038/s41598-019-56151-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09866, KAKENHI-PROJECT-19K19035, KAKENHI-PROJECT-19K21416, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-17K11993, KAKENHI-PROJECT-17H04050, KAKENHI-ORGANIZER-15H05935
[Journal Article] Anti-mouse RANKL Antibodies Inhibit Alveolar Bone Destruction in Periodontitis Model Mice2018
- Author(s)
  Kuritani M, Sakai N, Karakawa A, Isawa M, Chatani M, Negishi-Koga T, Funatsu T, Takami M.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 4 Pages: 637-643
- DOI
  10.1248/bpb.b18-00026
- NAID
  130006602562
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293398, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-16K20655, KAKENHI-PROJECT-18K09866, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-16K15778, KAKENHI-PUBLICLY-16H01635, KAKENHI-PROJECT-17K11993, KAKENHI-ORGANIZER-15H05935
[Journal Article] Biological effects of anti-RANKL antibody administration in pregnant mice and their newborns.2017
- Author(s)
  Okamatsu N, Sakai N, Karakawa A, Kouyama N, Sato Y, Inagaki K, Kiuchi Y, Oguchi K, Negishi-Koga T, Takami M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 491 Issue: 3 Pages: 614-621
- DOI
  10.1016/j.bbrc.2017.07.154
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293398, KAKENHI-PROJECT-17H04050, KAKENHI-PROJECT-16K20655, KAKENHI-PROJECT-17K11993
[Journal Article] Odontoblasts induced from mesenchymal cells of murine dental papillae in three-dimensional cell culture.2004
- Author(s)
  Kikuchi H, Suzuki K, Sakai N, Yamada S.
- Journal Title
  
  Cell Tissue Res 317・2
  
  Pages: 173-185
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571776
[Journal Article] Odontoblasts induced from mesenchymal cells of murine dental papillae in three-dimensional cell culture.2004
- Author(s)
  Kikuchi H, Suzuki K, Sakai N, Yamada S
- Journal Title
  
  Cell & Tissue Res 317(2)
  
  Pages: 173-185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571776
[Journal Article] Regulatory mechanisms and physiological relevance of a voltage-gated H+ channel in murine osteoclasts : phorbol myristate acetate induces cell acidosis and the channel activation.2003
- Author(s)
  Mori H, Sakai H, Morihata H, Kawawaki J, Amano H, Yamano T, Kuno
- Journal Title
  
  J Bone Miner Res. 18
  
  Pages: 2069-2076
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571776
[Journal Article] Regulatory mechanisms and physiological relevance of a voltage-gated H+ channel in murine osteoclasts : phorbol myristate acetate induces cell acidosis and the channel activation.2003
- Author(s)
  Mori H, Sakai H, Morihata H, Kawawaki J, Amano H, Yamano T, Kuno
- Journal Title
  
  J Bone Miner Res 18
  
  Pages: 2069-2076
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571776
[Presentation] 免疫抑制薬は骨芽細胞の分化ステージによって作用が異なる2023
- Author(s)
  西田訓子, 大竹開, 畔津佑季, 唐川亜希子, 茶谷昌宏, 坂井信裕, 高見正道
- Organizer
  第8回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 骨修復に対するタクロリムスの作用－遺伝子改変メダカとマウスを用いた解析－2023
- Author(s)
  畔津佑季，唐川亜希子，坂井信裕，高見正道
- Organizer
  第43回日本歯科薬物療法学会・4学会合同学術大会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 平面型カテキン[planar catechin:PCat]の骨量増加作用2023
- Author(s)
  菅原大貴, 高見正道, 畔津佑季, 唐川亜希子, 茶谷昌宏, 水野美麗, 福原潔, 坂井信裕
- Organizer
  第8回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 骨代謝に対する平面型カテキンの薬理作用2023
- Author(s)
  菅原大貴，畔津佑季，唐川亜希子，茶谷昌宏，坂井信裕，高見正道
- Organizer
  第41回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 餌中のコレステロールと脂質がマウスの骨と歯の恒常性を破壊する2022
- Author(s)
  佐藤ゆり絵，細沼雅弘, 菅原大輝, 畔津佑季, 唐川亜希子, 茶谷昌宏, 船津敬弘, 高見正道, 坂井信裕
- Organizer
  第69昭和大学学士会総会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] Focused Ion Beam Scanning Electron Microscope (FIB-SEM)を用いた破骨細胞の超微細立体構造の解析2022
- Author(s)
  細沼雅弘, 坂井信裕，松島英輝，高木孝士，武部明，髙見正道
- Organizer
  第７回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 神経堤由来細胞は創傷治癒過程においてケラチノサイトへの分化能を有する2022
- Author(s)
  瀧澤秀臣, 唐川亜希子, 須澤徹夫 , 茶谷昌宏 , 池田めぐみ , 坂井信裕, 畔津佑季 , 髙橋正皓 , 浦野絵里, 上條竜太郎 , 槇宏太郎 , 高見正道
- Organizer
  第７回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 妊娠マウスへの骨吸収抑制薬投与は仔マウスの歯の成長障害をもたらす2022
- Author(s)
  山口真帆，坂井信裕，唐川亜希子，茶谷昌宏，畔津佑季，高見正道
- Organizer
  第64回歯科基礎医学会総会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] ラットの骨髄－骨芽細胞共存培養系では破骨細胞が形成されない原因の解明2022
- Author(s)
  畔津佑季, 栗谷未来, 山口真帆, 茶谷昌宏,唐川亜希子, 坂井信裕, 高見正道
- Organizer
  第７回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 脂質およびコレステロールの摂取バランスがマウスの硬組織の恒常性に及ぼす影響2022
- Author(s)
  佐藤ゆり絵, 坂井信裕, 栗谷未来，唐川亜希子,畔津佑季, 茶谷昌宏, 高見正道
- Organizer
  第７回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 妊娠マウスへの抗RANKL抗体及びゾレドロネート投与は新生仔における歯の発生障害をもたらす2021
- Author(s)
  山口真帆，坂井信裕，佐藤ゆり絵，唐川亜希子，畔津佑季，茶谷昌宏，髙見正道
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 新規遺伝子Merlot は破骨細胞分化を阻害しアポトーシスを促進させる2021
- Author(s)
  山川智之，岡松伸明，石川紘司，清原秀一，飯田和章，坂井信裕，唐川亜希子，茶谷昌宏，辻まゆみ，稲垣克記，木内祐二，根岸貴子，髙見正道
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 口蓋創傷治癒過程における神経堤由来細胞の役割2021
- Author(s)
  瀧澤秀臣，唐川亜希子，茶谷昌宏，須澤徹夫，坂井信裕，畔津佑季，浦野絵里，上條竜太郎，槇宏太郎，高見正道
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 脂質およびコレステロール摂取量がマウスの歯と骨の恒常性に及ぼす影響2021
- Author(s)
  佐藤ゆり絵，坂井信裕，唐川亜希子，畔津佑季，茶谷昌宏，高見正道
- Organizer
  第63回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 骨吸収抑制薬が実験的根尖性歯周炎の成立に及ぼす影響の解析2021
- Author(s)
  池田めぐみ，瀧澤秀臣，唐川亜希子，坂井信裕，畔津佑季，茶谷昌宏，鈴木規元，髙見正道
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 高コレステロール食によって誘発されるマウス骨量低下の解析2020
- Author(s)
  佐藤ゆり絵，坂井信裕，黒滝優太朗，細沼雅弘，唐川亜希子，畔津佑季，茶谷昌宏，高見正道
- Organizer
  第38回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 抗RANKL 抗体とゾレドロネートがマウス実験的根尖性歯周炎の成立に及ぼす影響2020
- Author(s)
  池田めぐみ，瀧澤秀臣，唐川亜希子，坂井信裕，茶谷昌宏，畔津佑季，鈴木規元，高見正道
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 骨および歯の恒常性維持におけるグルココルチコイド受容体の機能-遺伝子改変メダカを用いた解析2020
- Author(s)
  畔津佑季，茶谷昌宏，唐川亜希子，坂井信裕，髙見正道
- Organizer
  第142回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] 脂質の過量摂取が歯の恒常性維持機構に及ぼす影響2020
- Author(s)
  坂井信裕，黒滝優太朗，佐藤ゆり絵，畔津佑季，唐川亜希子，茶谷昌宏，髙見正道
- Organizer
  第142回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20K09963
[Presentation] Hepatocyte growth factor(HGF)/ c-MET シグナル阻害は単球遊走を介した関節リウマチの骨破壊を抑制する2020
- Author(s)
  細沼雅弘，坂井信裕，黒滝優太朗，佐藤ゆり絵，古屋秀和，磯崎健男，古賀貴子，辻まゆみ，木内祐二，笠間毅，髙見正道
- Organizer
  第5回日本骨免疫学会ウィンタースクール
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] レドックスに関連する脂質代謝調節分子が細胞機能に及ぼす影響の解析 -２報-2019
- Author(s)
  坂井信裕，黒滝優太郎，丸岡靖史，宮崎拓郎，宮崎章，沼澤聡，高見正道
- Organizer
  平成30年度文部科学省私立大学研究ブランディング事業研究成果報告会・シンポジウム
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質異常症モデルマウスは切歯象牙質の肥厚と骨密度の減少を呈する2019
- Author(s)
  黒滝優太朗、坂井信裕、佐藤ゆり絵、唐川亜希子、茶谷昌弘、古賀貴子、丸岡靖史、高見正道
- Organizer
  第61回日本歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質異常症モデルマウスは切歯の象牙質肥厚を伴う歯髄狭窄を呈する2019
- Author(s)
  黒滝優太郎，坂井信裕，宮崎拓郎，細沼雅弘，佐藤ゆり絵，唐川亜希子，茶谷昌宏，マイヤース三恵，須澤徹夫，根岸（古賀）貴子，上條竜太郎，宮崎章，髙見正道，丸岡靖史
- Organizer
  第66回昭和大学学士会総会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 高脂肪食を摂餌したマウスの切歯は伸長速度の低下と歯髄狭窄を呈する2019
- Author(s)
  黒滝優太朗, 坂井信裕、白倉香子、菊池真理子、松井庄平、三宅理子、松浦光洋、マイヤース三恵、高見正道、丸岡靖史
- Organizer
  第28回日本有病者歯科医療学会総会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質代謝は歯と骨の恒常性維持を制御する2019
- Author(s)
  黒滝優太朗、坂井信裕、細沼雅弘、古賀貴子、唐川亜希子、茶谷昌宏、マイヤース三恵、丸岡靖史，高見正道
- Organizer
  第5回日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質異常症モデルマウスは切歯象牙質の肥厚と骨量減少を呈する2019
- Author(s)
  黒滝優太朗, 坂井信裕, 佐藤ゆり絵, 唐川亜希子, 茶谷昌弘, 古賀貴子, 高見正道
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質異常症モデルマウスは骨量減少と切歯の歯髄腔狭窄を発症する2019
- Author(s)
  黒滝優太朗, 坂井信裕, 浅井英之, 小野山薫, 白倉香子, 菊池真理子, 三宅理子, 高見正道, 丸岡靖史
- Organizer
  第73回日本口腔科学会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] MDA5の恒常的活性化がもたらすシングレトン・マートン症候群様の骨形成異常2019
- Author(s)
  早田信正, 坂井信裕, 加藤博己, 高見正道, 藤田尚志
- Organizer
  第６回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 光－電子相関顕微鏡法（CLEM）と集束イオンビーム走査電子顕微鏡（FIB-SEM）を用いた破骨細胞の三次元構造解析により示唆させる新たな骨吸収機構2019
- Author(s)
  細沼雅弘，坂井信裕，高木孝士，松島英輝，武部明，木内祐二，髙見正道
- Organizer
  日本顕微鏡学会第62回シンポジウム
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 関節リウマチの滑膜におけるHepatocyte growth factor (HGF)の発現と病的意義2019
- Author(s)
  細沼雅弘，磯崎健男，古屋秀和，黒滝優太朗，佐藤ゆり絵，坂井信裕，茶谷昌宏，唐川亜希子，古賀貴子，高見正道，辻まゆみ，木内祐二
- Organizer
  第26回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] レドックスに関連する脂質代謝調節分子が細胞機能に及ぼす影響の解析2018
- Author(s)
  坂井信裕，黒滝優太郎，丸岡靖史，宮崎拓郎，宮崎章，沼澤聡，高見正道
- Organizer
  平成29年度文部科学省私立大学研究ブランディング事業研究成果報告会・シンポジウム
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 脂質異常症モデルマウスは骨量減少と歯髄狭窄を発症する2018
- Author(s)
  黒滝優太朗，坂井信裕，唐川亜希子，茶谷昌弘，根岸-古賀貴子，高見正道
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] Administration of anti-RANKL antibody to pregnant mice results in impaired development of mammary gland and death of newborns2018
- Author(s)
  N. Sakai, N. Okamatsu, T. Negishi-Koga, A. Karakawa, M. Chatani, Y. Kiuchi, M. Takami
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 歯周病モデルマウスに対する抗RANKL抗体の歯槽骨破壊抑制効果2018
- Author(s)
  栗谷未来，坂井信裕，唐川亜希子，井澤基樹，黒滝優太朗，茶谷昌弘，根岸-古賀貴子，高見正道
- Organizer
  第36回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] Administration of anti-RANKL antibody to pregnant mice results in impaired development of mammary gland and death of newborns2017
- Author(s)
  N. Sakai, N. Okamatsu, T. Koga, A. Karakawa, M Takami
- Organizer
  第65回国際歯科研究学会日本部会総会学術大会(JADR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 抗RANKL抗体が妊娠マウスと胎児に与える影響2017
- Author(s)
  岡松伸明，坂井信裕，根岸貴子，木内裕二，小口勝司，高見正道
- Organizer
  第90回日本薬理学会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 骨吸収抑制作用を有する抗RANKL抗体（OYC1）を投与した妊娠マウスおよびその新生仔の解析2017
- Author(s)
  坂井信裕、岡松伸明、古賀貴子、唐川亜希子、稲垣克記、高見正道
- Organizer
  第35回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] Anti-RANKL Antibody Administration Suppresses Bone Destruction Induced by LPS in Mice2017
- Author(s)
  Miku Kuritani，Nobuhiro Sakai，Akiko Karakawa，Masahiro Chatani，Motoki Isawa, Takako Koga，TakahiroFunatsu，Masamichi Takami
- Organizer
  第65回国際歯科研究学会日本部会総会学術大会(JADR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] Skeletal abnormalities in mice with constitutively activated MDA52017
- Author(s)
  Nobumasa Soda, Nobuhiro Sakai, Hideo Onizawa, Masamichi Takami, Hiroki Kato, Takashi Fujita
- Organizer
  第５回国際インターフェロンサイトカイン学会(ICIS2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11993
[Presentation] 抗RANKL抗体とゾレドロネートがマウスのLPS誘導性炎症性骨破壊に及ぼす影響2017
- Author(s)
  栗谷未来、坂井信裕、唐川亜希子、茶谷昌宏、古賀貴子、高見正道
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11993

1. SUZUKI Keiko (50119187)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. AMANO Hitoshi (90212571)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. YAMADA Shoji (00111617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 古賀貴子 (90451905)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
5. 高見正道 (80307058)

# of Collaborated Projects: 2 results

# of Collaborated Products: 45 results
6. KAMATA Nobuyuki (70242211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUZAWA Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 唐川亜希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
9. 茶谷昌宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 上條竜太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 畔津佑季

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 石川紘司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakai Nobuhiro 坂井 信裕

SAKAI Nobuhiro 坂井 信裕

坂井 信宏 サカイ ノブヒロ

Research Projects

Research Products

Co-Researchers

歯科教育のためのPC上で医療面接が訓練できるバーチャルCG患者アプリケーションの開発Principal Investigator

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Lipid metabolic functions in tooth and bone homeostasisPrincipal Investigator

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Development of a method for suppressing bone destruction targeting cholesterol acyltransferase.Principal Investigator

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Role of intracellular osteopontin in the osteoclast fusion and tumor cell invasion

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Investigation on the role of osteopontin and CD44 in the osteoclast development

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Effect of VEGF's on osteockast formation and activation

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Function analysis of Na^+ dependent ion transporters in bone metabolism

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[Journal Article] Tacrolimus, FK506, promotes bone formation in bone defect mouse model2024

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[Journal Article] Abnormal bone regeneration induced by FK506 in medaka fin revealed by in vivo imaging2024

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[Journal Article] Planar catechin increases bone mass by regulating differentiation of osteoclasts in mice2024

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[Journal Article] 歯と骨の恒常性維持における脂質代謝機能の解明2024

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[Journal Article] Cholesterol and fat in diet disrupt bone and tooth homeostasis in mice2022

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[Journal Article] Neural crest-derived cells possess differentiation potential to keratinocytes in the process of wound healing2022

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[Journal Article] Effects of Anti?Receptor Activator of Nuclear Factor Kappa B Ligand Antibody and Zoledronic Acid on Periapical Lesion Development in Mice2022

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Sakai Nobuhiro 坂井信裕

SAKAI Nobuhiro 坂井信裕

坂井信宏サカイノブヒロ