Hayashi Takeharu 林丈晴

… Alternative Names

林丈晴ハヤシタケハル

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Researcher Number	90287186
Other IDs
Affiliation (Current)	2025: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 東海大学, 医学部, 教授 2019: 東海大学, 医学部, 教授 2018: 慶應義塾大学, 医学部(信濃町), 特任准教授 2014 – 2017: 東京医科歯科大学, 難治疾患研究所, 准教授
Review Section/Research Field	Principal Investigator Human genetics Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 遺伝子解析 / 心筋症 / 遺伝子変異 / 原因遺伝子 / ゲノム創薬 / 原因遺伝子解析 / 遺伝子 Except Principal Investigator 心室中部閉塞性肥大型心筋症 / ハイリスクグループ / RBM20 … More / 若年発症型肥大型心筋症 / 心室中部閉塞型肥大型心筋症 / 拡張相肥大型心筋症 / 肥大型心筋症 Less

Elucidation of pathogenesis in high-risk group hypertrophy cardiomyopathy
- Principal Investigator
  
  稲垣夏子
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokyo Medical University
Development of genetic etiology-based prevention and novel therapy for cardiomyopathyPrincipal Investigator
- Principal Investigator
  
  HAYASHI Takeharu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tokai University
  Keio University
  Tokyo Medical and Dental University
Development of new treatment and prevention strategy of heart failure based on novel pathogenesis of genetic cardiomyopathy.Principal Investigator
- Principal Investigator
  
  Hayashi Takeharu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Pediatric hypertrophic cardiomyopathy caused by a novel TNNI3 variant2024
- Author(s)
  Inagaki Natsuko、Okano Tomoya、Kobayashi Masatake、Fujii Masatsune、Yazaki Yoshinao、Takei Yasuyoshi、Kosuge Hisanori、Suzuki Shinji、Hayashi Takeharu、Kuroda Masahiko、Satomi Kazuhiro
- Journal Title
  
  Human Genome Variation
  
  Volume: 11 Issue: 1 Pages: 1-4
- DOI
  10.1038/s41439-024-00272-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08089, KAKENHI-PROJECT-21H02706
[Journal Article] Pathogenic variant of RBM20 in a multiplex family with hypertrophic cardiomyopathy2022
- Author(s)
  Inagaki Natsuko、Hayashi Takeharu、Takei Yasuyoshi、Kosuge Hisanori、Suzuki Shinji、Tanimoto Kousuke、Chikamori Taishiro、Kimura Akinori
- Journal Title
  
  Human Genome Variation
  
  Volume: 9 Issue: 1
- DOI
  10.1038/s41439-022-00183-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08089
[Journal Article] Hypertrophic Cardiomyopathy: Diverse Pathophysiology Revealed by Genetic Research, Toward Future Therapy2020
- Author(s)
  Hayashi Takeharu
- Journal Title
  
  The Keio Journal of Medicine
  
  Volume: 69 Issue: 4 Pages: 77-87
- DOI
  10.2302/kjm.2019-0012-OA
- NAID
  130007960011
- ISSN
  0022-9717, 1880-1293
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08684
[Journal Article] Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction2018
- Author(s)
  Inagaki Natsuko、Hayashi Takeharu、Takei Yasuyoshi、Tanimoto Kousuke、Chikamori Taishiro、Kimura Akinori
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 63 Issue: 12 Pages: 1273-1276
- DOI
  10.1038/s10038-018-0509-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08684, KAKENHI-PROJECT-16H05296
[Journal Article] Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy.2018
- Author(s)
  Harada H*, Hayashi T*, Nishi H, Kusaba K, Koga Y, Koga Y, Nonaka I, Kimura A
- Journal Title
  
  J Hum Genet.
  
  Volume: 63 Issue: 2 Pages: 249-254
- DOI
  10.1038/s10038-017-0383-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08684
[Journal Article] Barth syndrome associated with triple mutation.2018
- Author(s)
  Tsujii N, Nishikubo T. et al
- Journal Title
  
  Pediatr Int.
  
  Volume: 60 Issue: 4 Pages: 385-7
- DOI
  10.1111/ped.13517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10103, KAKENHI-PROJECT-16H05296, KAKENHI-PROJECT-17K08684
[Journal Article] Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy2018
- Author(s)
  Hayashi Takeharu、Tanimoto Kousuke、Hirayama-Yamada Kayoko、Tsuda Etsuko、Ayusawa Mamoru、Nunoda Shinichi、Hosaki Akira、Kimura Akinori
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 63 Issue: 9 Pages: 989-996
- DOI
  10.1038/s10038-018-0479-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08684, KAKENHI-PROJECT-16H05296
[Journal Article] Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization2018
- Author(s)
  Rie Murayama, Mariko Kimura-Asami, Marina Togo-Ohno, Yumiko Yamasaki-Kato, Taeko K. Naruse, Takeshi Yamamoto, Takeharu Hayashi, Tomohiko Ai, Katherine G. Spoonamore, Richard J. Kovacs, Matteo Vatta, Mai Iizuka, Masumi Saito, Shotaro Wani, Yuichi Hiraoka, Akinori Kimura & Hidehito Kuroyanagi
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中 Issue: 1 Pages: 8970-8983
- DOI
  10.1038/s41598-018-26624-w
- NAID
  120007031665
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01350, KAKENHI-PROJECT-17K08684, KAKENHI-PUBLICLY-17H05596, KAKENHI-PROJECT-16H05296, KAKENHI-PROJECT-17H03633, KAKENHI-PROJECT-15KK0252
[Journal Article] Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.2018
- Author(s)
  Arimura T, Muchir A, Kuwahara M, Morimoto S, Ishikawa T, Du CK, Zhan DY, Nakao S, Machida N, Tanaka R, Yamane Y, Hayashi T, Kimura A.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08684
[Journal Article] Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and Zebra body2016
- Author(s)
  Oikawa M, Sakamoto N, Kobayashi A, Suzuki A, Yoshihisa A. Yamaki T, Nakazato K, Suzuki H, Saitoh S, Kiko Y, Nakano H, Hayashi T, Kimura A, Takeishi Y
- Journal Title
  
  BMC Cardiovasc Disord.
  
  Volume: 16 Issue: 1 Pages: 83-83
- DOI
  10.1186/s12872-016-0262-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05296, KAKENHI-PROJECT-15K09090, KAKENHI-PROJECT-15K09143, KAKENHI-PROJECT-26460407
[Journal Article] Screening of sarcomere gene mutations in young athletes with abnormal findings in electrocardiography: identification of a MYH7 mutation and MYBPC3 mutations.2015
- Author(s)
  Kadota C, Arimura T, Hayashi T, Naruse TK, Kawai S, Kimura A
- Journal Title
  
  Journal of human genetics
  
  Volume: 60 Issue: 10 Pages: 641-645
- DOI
  10.1038/jhg.2015.81
- NAID
  40020621514
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460407, KAKENHI-PROJECT-25293181
[Journal Article] Development of personalized medicine and therapy for cardiomyopathy based on the pathogensis: Identification of novel disease causative gene by comprehensive mutation analysis.2014
- Author(s)
  Hayashi T, Kimura A
- Journal Title
  
  Journal of Seizon and Life Science
  
  Volume: 25 Pages: 221-227
- Data Source
  KAKENHI-PROJECT-26460407
[Presentation] Utility of Genetic Analysis for Dilated Phase of Hypertrophic Cardiomyopathy, a High-Risk Group2023
- Author(s)
  稲垣夏子　林丈晴
- Organizer
  第14回アジアパシフィック人類遺伝学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08089
[Presentation] 心臓突然死予防を要する肥大型心筋症の病因解明に向けて2023
- Author(s)
  林丈晴　稲垣夏子
- Organizer
  第71回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08089
[Presentation] Utility of Genetic Analysis for Dilated Phase of Hypertrophic Cardiomyopathy, a High-Risk Group2023
- Author(s)
  稲垣夏子　林丈晴
- Organizer
  第68回日本人類遺伝学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08089
[Presentation] A study of four cases with Fabry's disease presenting with midventricular obstructive hypertrophic cardiomyopathy .2022
- Author(s)
  稲垣夏子　林丈晴
- Organizer
  第67回日本人類遺伝学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08089
[Presentation] RBM20 gene may be a novel causative gene for hypertrophic cardiomyopathy2021
- Author(s)
  稲垣夏子　林丈晴
- Organizer
  第66回日本人類遺伝学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08089
[Presentation] 日本人拡張型心筋症の原因遺伝子解析2017
- Author(s)
  林　丈晴、山田佳代子、谷本幸介、木村彰方.
- Organizer
  第62回日本人類遺伝学会
- Data Source
  KAKENHI-PROJECT-17K08684
[Presentation] Genetic analysis of hypertrophic cardiomyopathy with mid-ventricular obstruction phenotype.2017
- Author(s)
  Inagaki N, Hayashi T, Takei Y, Chikamori T, Yamashina A、Kimura A.
- Organizer
  第81回日本循環器学会
- Place of Presentation
  石川県立音楽堂　金沢県金沢市
- Year and Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-26460407
[Presentation] 若年、小児発症の肥大型及び拘束型心筋症の原因遺伝子解析2016
- Author(s)
  林　丈晴、谷本幸介、木村彰方.
- Organizer
  第２回　日本心筋症研究会
- Place of Presentation
  まつもと市民芸術館　長野県松本市
- Year and Date
  2016-05-14
- Data Source
  KAKENHI-PROJECT-26460407
[Presentation] 心筋症の遺伝子解析の現状2015
- Author(s)
  林丈晴、谷本幸介、木村彰方
- Organizer
  第１回日本心筋症研究会
- Place of Presentation
  一橋講堂、東京都千代田区
- Year and Date
  2015-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26460407
[Presentation] 若年及び小児の肥大型、拘束型心筋症の遺伝子変異解析2015
- Author(s)
  林丈晴、谷本幸介、木村彰方
- Organizer
  第60回日本人類遺伝学会
- Place of Presentation
  京王プラザホテル、東京都新宿区
- Year and Date
  2015-10-15
- Data Source
  KAKENHI-PROJECT-26460407
[Presentation] 心室中部閉塞型肥大型心筋症の病因変異探索2015
- Author(s)
  稲垣夏子、林丈晴、武井康悦、近森大志郎、山科章、木村彰方
- Organizer
  第60回日本人類遺伝学会
- Place of Presentation
  京王プラザホテル、東京都新宿区
- Year and Date
  2015-10-15
- Data Source
  KAKENHI-PROJECT-26460407
[Presentation] 心室中部閉塞型肥大型心筋症の病因変異探索2015
- Author(s)
  稲垣夏子, 林丈晴, 武井康悦, 近森大志郎, 山科章, 木村彰方
- Organizer
  第１回日本心筋症研究会
- Place of Presentation
  一橋講堂、東京都千代田区
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-26460407
[Presentation] 心室中部閉塞型肥大型心筋症の病因変異探索2014
- Author(s)
  稲垣夏子、林丈晴、武井康悦、近森大志郎、谷本幸介、山科章、木村彰方
- Organizer
  日本人類遺伝学会第59回大会
- Place of Presentation
  タワーホール船堀 ,東京都
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-26460407
[Presentation] 遺伝性心筋症変異スクリーニングシステムの構築2014
- Author(s)
  林丈晴、谷本幸介、木村彰方.
- Organizer
  日本人類遺伝学会第59回大会
- Place of Presentation
  タワーホール船堀, 東京
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-26460407

1. 木村彰方 (60161551)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. 稲垣夏子 (10424368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. 西久保敏也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 黒柳秀人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Takeharu 林 丈晴

林 丈晴 ハヤシ タケハル

Research Projects

Research Products

Co-Researchers

Elucidation of pathogenesis in high-risk group hypertrophy cardiomyopathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of genetic etiology-based prevention and novel therapy for cardiomyopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new treatment and prevention strategy of heart failure based on novel pathogenesis of genetic cardiomyopathy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pediatric hypertrophic cardiomyopathy caused by a novel TNNI3 variant2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathogenic variant of RBM20 in a multiplex family with hypertrophic cardiomyopathy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypertrophic Cardiomyopathy: Diverse Pathophysiology Revealed by Genetic Research, Toward Future Therapy2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Barth syndrome associated with triple mutation.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.2018

Author(s)

Journal Title

Data Source

[Journal Article] Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and Zebra body2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Screening of sarcomere gene mutations in young athletes with abnormal findings in electrocardiography: identification of a MYH7 mutation and MYBPC3 mutations.2015

Author(s)

Journal Title

DOI

Hayashi Takeharu 林丈晴

林丈晴ハヤシタケハル