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Hayashi Takeharu  林 丈晴

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… Alternative Names

林 丈晴  ハヤシ タケハル

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Researcher Number 90287186
Other IDs
Affiliation (Current) 2025: 東海大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2021 – 2023: 東海大学, 医学部, 教授
2019: 東海大学, 医学部, 教授
2018: 慶應義塾大学, 医学部(信濃町), 特任准教授
2014 – 2017: 東京医科歯科大学, 難治疾患研究所, 准教授
Review Section/Research Field
Principal Investigator
Human genetics
Except Principal Investigator
Basic Section 53020:Cardiology-related
Keywords
Principal Investigator
遺伝子解析 / 心筋症 / 遺伝子変異 / 原因遺伝子 / ゲノム創薬 / 原因遺伝子解析 / 遺伝子
Except Principal Investigator
心室中部閉塞性肥大型心筋症 / ハイリスクグループ / RBM20 … More / 若年発症型肥大型心筋症 / 心室中部閉塞型肥大型心筋症 / 拡張相肥大型心筋症 / 肥大型心筋症 Less
  • Research Projects

    (3 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (4 People)
  •  Elucidation of pathogenesis in high-risk group hypertrophy cardiomyopathy

    • Principal Investigator
      稲垣 夏子
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Tokyo Medical University
  •  Development of genetic etiology-based prevention and novel therapy for cardiomyopathyPrincipal Investigator

    • Principal Investigator
      HAYASHI Takeharu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Tokai University
      Keio University
      Tokyo Medical and Dental University
  •  Development of new treatment and prevention strategy of heart failure based on novel pathogenesis of genetic cardiomyopathy.Principal Investigator

    • Principal Investigator
      Hayashi Takeharu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human genetics
    • Research Institution
      Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2018 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] Pediatric hypertrophic cardiomyopathy caused by a novel TNNI3 variant2024

    • Author(s)
      Inagaki Natsuko、Okano Tomoya、Kobayashi Masatake、Fujii Masatsune、Yazaki Yoshinao、Takei Yasuyoshi、Kosuge Hisanori、Suzuki Shinji、Hayashi Takeharu、Kuroda Masahiko、Satomi Kazuhiro
    • Journal Title

      Human Genome Variation

      Volume: 11 Issue: 1 Pages: 1-4

    • DOI

      10.1038/s41439-024-00272-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08089, KAKENHI-PROJECT-21H02706
  • [Journal Article] Pathogenic variant of RBM20 in a multiplex family with hypertrophic cardiomyopathy2022

    • Author(s)
      Inagaki Natsuko、Hayashi Takeharu、Takei Yasuyoshi、Kosuge Hisanori、Suzuki Shinji、Tanimoto Kousuke、Chikamori Taishiro、Kimura Akinori
    • Journal Title

      Human Genome Variation

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41439-022-00183-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08089
  • [Journal Article] Hypertrophic Cardiomyopathy: Diverse Pathophysiology Revealed by Genetic Research, Toward Future Therapy2020

    • Author(s)
      Hayashi Takeharu
    • Journal Title

      The Keio Journal of Medicine

      Volume: 69 Issue: 4 Pages: 77-87

    • DOI

      10.2302/kjm.2019-0012-OA

    • NAID

      130007960011

    • ISSN
      0022-9717, 1880-1293
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08684
  • [Journal Article] Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction2018

    • Author(s)
      Inagaki Natsuko、Hayashi Takeharu、Takei Yasuyoshi、Tanimoto Kousuke、Chikamori Taishiro、Kimura Akinori
    • Journal Title

      Journal of Human Genetics

      Volume: 63 Issue: 12 Pages: 1273-1276

    • DOI

      10.1038/s10038-018-0509-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08684, KAKENHI-PROJECT-16H05296
  • [Journal Article] Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy.2018

    • Author(s)
      Harada H*, Hayashi T*, Nishi H, Kusaba K, Koga Y, Koga Y, Nonaka I, Kimura A
    • Journal Title

      J Hum Genet.

      Volume: 63 Issue: 2 Pages: 249-254

    • DOI

      10.1038/s10038-017-0383-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08684
  • [Journal Article] Barth syndrome associated with triple mutation.2018

    • Author(s)
      Tsujii N, Nishikubo T. et al
    • Journal Title

      Pediatr Int.

      Volume: 60 Issue: 4 Pages: 385-7

    • DOI

      10.1111/ped.13517

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10103, KAKENHI-PROJECT-16H05296, KAKENHI-PROJECT-17K08684
  • [Journal Article] Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy2018

    • Author(s)
      Hayashi Takeharu、Tanimoto Kousuke、Hirayama-Yamada Kayoko、Tsuda Etsuko、Ayusawa Mamoru、Nunoda Shinichi、Hosaki Akira、Kimura Akinori
    • Journal Title

      Journal of Human Genetics

      Volume: 63 Issue: 9 Pages: 989-996

    • DOI

      10.1038/s10038-018-0479-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08684, KAKENHI-PROJECT-16H05296
  • [Journal Article] Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization2018

    • Author(s)
      Rie Murayama, Mariko Kimura-Asami, Marina Togo-Ohno, Yumiko Yamasaki-Kato, Taeko K. Naruse, Takeshi Yamamoto, Takeharu Hayashi, Tomohiko Ai, Katherine G. Spoonamore, Richard J. Kovacs, Matteo Vatta, Mai Iizuka, Masumi Saito, Shotaro Wani, Yuichi Hiraoka, Akinori Kimura & Hidehito Kuroyanagi
    • Journal Title

      Scientific Reports

      Volume: 印刷中 Issue: 1 Pages: 8970-8983

    • DOI

      10.1038/s41598-018-26624-w

    • NAID

      120007031665

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01350, KAKENHI-PROJECT-17K08684, KAKENHI-PUBLICLY-17H05596, KAKENHI-PROJECT-16H05296, KAKENHI-PROJECT-17H03633, KAKENHI-PROJECT-15KK0252
  • [Journal Article] Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.2018

    • Author(s)
      Arimura T, Muchir A, Kuwahara M, Morimoto S, Ishikawa T, Du CK, Zhan DY, Nakao S, Machida N, Tanaka R, Yamane Y, Hayashi T, Kimura A.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08684
  • [Journal Article] Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and Zebra body2016

    • Author(s)
      Oikawa M, Sakamoto N, Kobayashi A, Suzuki A, Yoshihisa A. Yamaki T, Nakazato K, Suzuki H, Saitoh S, Kiko Y, Nakano H, Hayashi T, Kimura A, Takeishi Y
    • Journal Title

      BMC Cardiovasc Disord.

      Volume: 16 Issue: 1 Pages: 83-83

    • DOI

      10.1186/s12872-016-0262-y

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05296, KAKENHI-PROJECT-15K09090, KAKENHI-PROJECT-15K09143, KAKENHI-PROJECT-26460407
  • [Journal Article] Screening of sarcomere gene mutations in young athletes with abnormal findings in electrocardiography: identification of a MYH7 mutation and MYBPC3 mutations.2015

    • Author(s)
      Kadota C, Arimura T, Hayashi T, Naruse TK, Kawai S, Kimura A
    • Journal Title

      Journal of human genetics

      Volume: 60 Issue: 10 Pages: 641-645

    • DOI

      10.1038/jhg.2015.81

    • NAID

      40020621514

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460407, KAKENHI-PROJECT-25293181
  • [Journal Article] Development of personalized medicine and therapy for cardiomyopathy based on the pathogensis: Identification of novel disease causative gene by comprehensive mutation analysis.2014

    • Author(s)
      Hayashi T, Kimura A
    • Journal Title

      Journal of Seizon and Life Science

      Volume: 25 Pages: 221-227

    • Data Source
      KAKENHI-PROJECT-26460407
  • [Presentation] Utility of Genetic Analysis for Dilated Phase of Hypertrophic Cardiomyopathy, a High-Risk Group2023

    • Author(s)
      稲垣夏子 林丈晴
    • Organizer
      第14回アジアパシフィック人類遺伝学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08089
  • [Presentation] 心臓突然死予防を要する肥大型心筋症の病因解明に向けて2023

    • Author(s)
      林丈晴 稲垣夏子
    • Organizer
      第71回日本心臓病学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08089
  • [Presentation] Utility of Genetic Analysis for Dilated Phase of Hypertrophic Cardiomyopathy, a High-Risk Group2023

    • Author(s)
      稲垣夏子 林丈晴
    • Organizer
      第68回日本人類遺伝学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08089
  • [Presentation] A study of four cases with Fabry's disease presenting with midventricular obstructive hypertrophic cardiomyopathy .2022

    • Author(s)
      稲垣夏子 林丈晴
    • Organizer
      第67回日本人類遺伝学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08089
  • [Presentation] RBM20 gene may be a novel causative gene for hypertrophic cardiomyopathy2021

    • Author(s)
      稲垣夏子 林丈晴
    • Organizer
      第66回日本人類遺伝学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08089
  • [Presentation] 日本人拡張型心筋症の原因遺伝子解析2017

    • Author(s)
      林 丈晴、山田佳代子、谷本幸介、木村彰方.
    • Organizer
      第62回日本人類遺伝学会
    • Data Source
      KAKENHI-PROJECT-17K08684
  • [Presentation] Genetic analysis of hypertrophic cardiomyopathy with mid-ventricular obstruction phenotype.2017

    • Author(s)
      Inagaki N, Hayashi T, Takei Y, Chikamori T, Yamashina A、Kimura A.
    • Organizer
      第81回日本循環器学会
    • Place of Presentation
      石川県立音楽堂 金沢県金沢市
    • Year and Date
      2017-03-18
    • Data Source
      KAKENHI-PROJECT-26460407
  • [Presentation] 若年、小児発症の肥大型及び拘束型心筋症の原因遺伝子解析2016

    • Author(s)
      林 丈晴、谷本幸介、木村彰方.
    • Organizer
      第2回 日本心筋症研究会
    • Place of Presentation
      まつもと市民芸術館 長野県松本市
    • Year and Date
      2016-05-14
    • Data Source
      KAKENHI-PROJECT-26460407
  • [Presentation] 心筋症の遺伝子解析の現状2015

    • Author(s)
      林丈晴、谷本幸介、木村彰方
    • Organizer
      第1回日本心筋症研究会
    • Place of Presentation
      一橋講堂、東京都千代田区
    • Year and Date
      2015-07-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460407
  • [Presentation] 若年及び小児の肥大型、拘束型心筋症の遺伝子変異解析2015

    • Author(s)
      林丈晴、谷本幸介、木村彰方
    • Organizer
      第60回日本人類遺伝学会
    • Place of Presentation
      京王プラザホテル、東京都新宿区
    • Year and Date
      2015-10-15
    • Data Source
      KAKENHI-PROJECT-26460407
  • [Presentation] 心室中部閉塞型肥大型心筋症の病因変異探索2015

    • Author(s)
      稲垣夏子、林丈晴、武井康悦、近森大志郎、山科章、木村彰方
    • Organizer
      第60回日本人類遺伝学会
    • Place of Presentation
      京王プラザホテル、東京都新宿区
    • Year and Date
      2015-10-15
    • Data Source
      KAKENHI-PROJECT-26460407
  • [Presentation] 心室中部閉塞型肥大型心筋症の病因変異探索2015

    • Author(s)
      稲垣夏子, 林丈晴, 武井康悦, 近森大志郎, 山科章, 木村彰方
    • Organizer
      第1回日本心筋症研究会
    • Place of Presentation
      一橋講堂、東京都千代田区
    • Year and Date
      2015-07-04
    • Data Source
      KAKENHI-PROJECT-26460407
  • [Presentation] 心室中部閉塞型肥大型心筋症の病因変異探索2014

    • Author(s)
      稲垣夏子、林丈晴、武井康悦、近森大志郎、谷本幸介、山科章、木村彰方
    • Organizer
      日本人類遺伝学会第59回大会
    • Place of Presentation
      タワーホール船堀 ,東京都
    • Year and Date
      2014-11-20
    • Data Source
      KAKENHI-PROJECT-26460407
  • [Presentation] 遺伝性心筋症変異スクリーニングシステムの構築2014

    • Author(s)
      林丈晴、谷本幸介、木村彰方.
    • Organizer
      日本人類遺伝学会第59回大会
    • Place of Presentation
      タワーホール船堀, 東京
    • Year and Date
      2014-11-20
    • Data Source
      KAKENHI-PROJECT-26460407
  • 1.  木村 彰方 (60161551)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 16 results
  • 2.  稲垣 夏子 (10424368)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 3.  西久保 敏也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  黒柳 秀人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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