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SEKINE Kazuhiko  関根 和彦

ORCIDConnect your ORCID iD *help
Researcher Number 90296715
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2015: 慶應義塾大学, 医学部, 講師
2014: 慶應義塾大学, 医学部, 研究員
2013 – 2014: 慶應義塾大学, 医学部, 客員講師
2012: 慶應義塾大学, 医学部, 研究員
2010: 慶應義塾大学, 医学部, 共同研究員 … More
2008 – 2010: 慶應義塾大学, 医学部, 助教
2007: Keio University, School of Medicine, Researcher
2006: 慶應義塾大学, 医学部, 協同研究員
2004: Keio University, Department of Medicine, Instructor, 医学部, 助手
2002: 東北大学, 大学院・医学系研究科, 助手
2001: Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Instructor, 医学部, 助手
2001: 東北大学, 医学部, 助手
1999: Keio University, School of Medicine, Instructor, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Emergency medicine
Except Principal Investigator
Emergency medicine / General surgery / Anesthesiology/Resuscitation studies / Respiratory organ internal medicine
Keywords
Principal Investigator
易感染性 / 白血球フェノタイプ / 免疫不全 / 表面抗原 / アレイ / 熱傷 / 外傷 / フェノタイプ解析 / 白血球 / 臓器不全 … More / 侵襲 / 免疫 / 外傷・熱傷 / 臨床 / 免疫学 / 外科 … More
Except Principal Investigator
sepsis / SIRS / 高体温 / ARDS / MCP-1 / LPS / priming / HGF / 高濃度酸素 / hyperoxia / NRAMP1 / hyperthermia / hypothermia / cytokine / interleukin-8 / 低体温 / サイトカイン / 敗血症 / 熱傷 / 外傷 / 臓器障害 / IL-8 / IL-18 / TNF / protein C / 高温環境 / MDC / CCL22 / Sepsis / coagulation and fibrinolysis / インターロイキン12 / MAPキナーゼ / 好中球エラスターゼ / 凝固因子 / インターロイキン18 / 凝固線溶系 / 熱中症 / survival / acidosis / tissue oxygen metabolism / fluid replacement / resuscitation / experimental model / hemorrhagic shock / 酸素代謝 / トノメーター / 血栓 / 出血モデル / ショック / 動脈血酸素分圧 / 生存率 / アシドーシス / 組織酸素代謝 / 輸液 / 蘇生 / 実験モデル / 出血性ショック / gene polymorphism / chemokine / 肺結核症 / interleukin 18 / interleukin 8 / 肺線維症 / 炎症性肺疾患 / Iinterleukin-8 / 遺伝子多型 / ケモカイン / whole blood culture / body temperature / IL-6 / TNFα / 全血培養 / 体温 / 集中治療 / 免疫学 / 易感染性 / 重度熱傷 / 臓器不全 / 広範囲熱傷 / 多発外傷 / 敗血症性ショック / 重症患者 / プロテインアレイ法 / 白血球表面抗原 / ALI / Interleukin-17 / 急性肺損傷 / Interleukin-18 / interleukin-17 / interleukin-18 / CCR4 / IL-10 Less
  • Research Projects

    (10 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (18 People)
  •  Anticipation of organ dysfunction by immmunological monitoring in severe trauma and burnsPrincipal Investigator

    • Principal Investigator
      Sekine Kazuhiko
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Keio University
  •  Immunophenotyping for detecting susceptibility to infection and organ failure in critically ill patients

    • Principal Investigator
      TAMURA Tomoyoshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Keio University
  •  Leukocyte immunophenotyping by a novel method of array system to predict infectious complications in patients with burns or traumaPrincipal Investigator

    • Principal Investigator
      SEKINE Kazuhiko
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Keio University
  •  New insight into paracellular environmental changes under severe insults and their application to critically ill patients

    • Principal Investigator
      FUJISHIM Seitaro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Keio University
  •  インターロイキン18による抗炎症療法の開発

    • Principal Investigator
      FUJISHIM Seitaro
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Keio University
  •  Immunological and metabolic changes induced by severe insults : insights into its pathophysiology and a development of new therapies

    • Principal Investigator
      AIKAWA Naoki
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Keio University
  •  Analysis of altered immunological responses under abnormal environmental conditions, including environmental temperature, and the trial of its active modulation for the treatment of critically ill patients

    • Principal Investigator
      AIKAWA Naoki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Keio University
  •  An experimental study on hypotensive resuscitation of near-lethal uncontrolled hemorrhage : Effects on tissue dysoxia, mortality and end-organ function at 72 hours

    • Principal Investigator
      AOKI Katsunori
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Hamamatsu University School of Medicine
      Keio University
  •  An approach to the pathogenesis of inflammatory lung diseases by establishing efficient analytical protocols for multiple mediator gene polymorphisms

    • Principal Investigator
      FUJISHIMA Seitaro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Keio University
  •  Biomedical responses to changes in body temperature in ciritically ill patients

    • Principal Investigator
      AIKAWA Naoki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Keio University

All 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation Book Patent

  • [Book] 重症患者lipopolysaccharide(LPS)高感受性機序の解明:IL-18の免疫修飾作用2010

    • Author(s)
      藤島清太郎、関根和彦, ら
    • Total Pages
      5
    • Publisher
      医学図書出版
    • Data Source
      KAKENHI-PROJECT-20592127
  • [Book] IL-18の免疫修飾作用(エンドトキシン研究:重症患者lipopolysaccharide (LPS)高感受性機序の解明)2010

    • Author(s)
      藤島清太郎、関根和彦, ら
    • Publisher
      医学図書出版
    • Data Source
      KAKENHI-PROJECT-20592127
  • [Journal Article] In vivo IL-18 supplementation ameliorates lethal acute lung injury in burn-primed endotoxemic mice : a novel anti-inflammatory role of IL-182009

    • Author(s)
      関根和彦, 藤島清太郎, et al.
    • Journal Title

      Shock Vol 32, No5

      Pages: 554-562

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592127
  • [Journal Article] In vivo IL-18 supplementation ameliorates lethal acute lung injury in burn-primed endotoxemic mice : a novel anti-inflammatory role of IL-182009

    • Author(s)
      Sekine K, Fujishima S, et al.
    • Journal Title

      Shock 32(5)

      Pages: 554-562

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592127
  • [Journal Article] Sepsisに対する新規治療戦略 : 一次侵襲後の免疫・栄養学的予防療法2008

    • Author(s)
      藤島清太郎, 関根和彦, 宮木大, 他
    • Journal Title

      Shock 23

      Pages: 53-58

    • NAID

      10024300614

    • Data Source
      KAKENHI-PROJECT-20592127
  • [Journal Article] Sepsisに対する新規治療戦略:一次侵襲後の免疫・栄養学的予防療法2008

    • Author(s)
      藤島清太郎,関根和彦,宮木大,他
    • Journal Title

      Shock Vol 23

      Pages: 53-58

    • NAID

      10024300614

    • Data Source
      KAKENHI-PROJECT-20592127
  • [Journal Article] 輸液療法に反応した深在性複雑型肝損傷における非手術的治療の限界2007

    • Author(s)
      関根和彦, [相川直樹]他
    • Journal Title

      日本腹部救急医学会雑誌 27

      Pages: 155-155

    • Data Source
      KAKENHI-PROJECT-17390482
  • [Journal Article] 生体侵襲・生体反応と臓器不全2006

    • Author(s)
      藤島清太郎, 関根和彦, 相川直樹
    • Journal Title

      救急医学 30

      Pages: 1025-1031

    • Data Source
      KAKENHI-PROJECT-17390482
  • [Journal Article] Plasma hepatocyte growth factor is increased in early-phase sepsis2004

    • Author(s)
      Sekine K, Fujishima S, Aikawa N, et al.
    • Journal Title

      J Infect Chemother 10(2)

      Pages: 110-114

    • NAID

      10016521422

    • Data Source
      KAKENHI-PROJECT-14370364
  • [Journal Article] Plasma hepatocyte growth factor is increased in early-phase sepsis.2004

    • Author(s)
      Kazuhiko Sekine, Seitaro Fujishima, Naoki Aikawa
    • Journal Title

      J Infect Chemother Vol.10

      Pages: 110-114

    • NAID

      10016521422

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370364
  • [Journal Article] Plasma hepatocyte growth factor is increased in early-phase sepsis.2004

    • Author(s)
      Sekine K, Fujishima S, Aikawa N
    • Journal Title

      J Infect Chemother 110

      Pages: 110-114

    • NAID

      10016521422

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370364
  • [Patent] 医薬組成物及び治療方法2004

    • Inventor(s)
      相川 直樹, 藤島 清太郎, 関根 和彦
    • Industrial Property Rights Holder
      慶應義塾
    • Industrial Property Number
      2004-145971
    • Filing Date
      2004-05-21
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370364
  • [Patent] 医薬組成物及び治療方法2004

    • Inventor(s)
      相川 直樹, 藤島 清太郎, 関根 和彦
    • Industrial Property Rights Holder
      慶應義塾
    • Filing Date
      2004-05-21
    • Data Source
      KAKENHI-PROJECT-14370364
  • [Presentation] 重度外傷・熱傷患者に対する新たなimmunophenotyping法の開発2010

    • Author(s)
      関根和彦
    • Organizer
      第25回、日本Shock学会総会
    • Place of Presentation
      シェーンバッハサボー(東京)
    • Year and Date
      2010-05-29
    • Data Source
      KAKENHI-PROJECT-21791777
  • [Presentation] 重度外傷・熱傷患者に対する新たなimmunophenotyping法の開発2010

    • Author(s)
      関根和彦、葉季久雄、安倍晋也、佐々木淳一、藤島清太郎、堀進悟、相川直樹
    • Organizer
      第25回日本Shock学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-29
    • Data Source
      KAKENHI-PROJECT-21791777
  • [Presentation] Plasma interleukin-18 levels in patients with sublethal burns2010

    • Author(s)
      Kazuhiko SEKINE
    • Organizer
      15^<th> congress, International Society for Burn Injuries.
    • Place of Presentation
      Istanbul, Turkey
    • Data Source
      KAKENHI-PROJECT-21791777
  • [Presentation] Plasma interleukin-18 levels in patients with sublethal burns.2010

    • Author(s)
      Sekine K, Fujishima S, Yo K, Kurihara T, Abe S, Sato Y, Hori S, Aikawa N
    • Organizer
      15^<th> International Society for Burn Injuries
    • Place of Presentation
      Istanbul, Turkey.
    • Data Source
      KAKENHI-PROJECT-21791777
  • [Presentation] 重症患者lipopolysaccharide (LPS)高感受性機序の解明:IL-18の免疫修飾作用2009

    • Author(s)
      藤島清太郎、関根和彦, ら
    • Organizer
      第15回日本エンドトキシン研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Data Source
      KAKENHI-PROJECT-20592127
  • [Presentation] 重症患者 lipopolysaccharide(LPS)高感受性機序の解明 : IL-18の免疫修飾作用2009

    • Author(s)
      藤島清太郎, 関根和彦, ら
    • Organizer
      第15回日本エンドトキシン研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Data Source
      KAKENHI-PROJECT-20592127
  • [Presentation] 脾細胞に対するインターロイキン18の免疫修飾作用2007

    • Author(s)
      藤島清太郎、関根和彦, 他
    • Organizer
      第25回日本ヒト細胞学会
    • Place of Presentation
      東京
    • Year and Date
      2007-08-04
    • Data Source
      KAKENHI-PROJECT-19659474
  • [Presentation] 外科的侵襲による生体反応-サイトカインと臓器障害-

    • Author(s)
      関根和彦
    • Organizer
      第6回 日本 Acute Care Surgery 学会
    • Place of Presentation
      青森
    • Year and Date
      2014-09-20 – 2014-09-21
    • Data Source
      KAKENHI-PROJECT-24592748
  • [Presentation] パネルディスカッション2 敗血症の病態と治療:新たなる視点と展望: 重度外傷・熱傷患者において白血球フェノタイプの変化から感染合併症が予知できるか?

    • Author(s)
      関根和彦
    • Organizer
      第42回 日本救急医学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-10-28 – 2014-10-30
    • Data Source
      KAKENHI-PROJECT-24592748
  • 1.  FUJISHIM Seitaro (00173419)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 13 results
  • 2.  AIKAWA Naoki (40110879)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 3.  MIYAKI Masaru (60365400)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 4.  AOKI Katsunori (20124927)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  HORI Shingo (80129650)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  YOH Kikuo (00327644)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  山崎 元靖 (00296716)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  NAKANO Yasushi (90528225)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  TAMURA Tomoyoshi (00571720)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KIMURA Hiroyuki (00225054)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  YOGO Yurika (90306712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  TATENO Hiroki (50286473)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HIRAOKA Yoshiki (80218768)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NISHINA Masayoshi (20180622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  芳賀 純子 (40398623)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  堀口 崇 (70245520)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  篠沢 洋太郎 (30129465)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  並木 淳 (20189195)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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