Nagamitsu Tohru 長光亨

… Alternative Names

長光亨ナガミツトオル

NAGAMITSU Toru 長光亨

NAGAMITSU Tohru 長光亨

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Researcher Number	90300756
Other IDs
Affiliation (Current)	2025: 北里大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 北里大学, 薬学部, 教授 2014 – 2016: 北里大学, 薬学部, 教授 2010 – 2012: 北里大学, 薬学部, 教授 2007 – 2008: 北里大学, 薬学部, 准教授 2005 – 2006: 北里大学, 薬学部, 助教授 2003 – 2004: 北里大学, 薬学部, 講師 2002: 北里大学, 薬学部・薬品製造化学研究室, 講師
Review Section/Research Field	Principal Investigator Chemical pharmacy / Basic Section 33020:Synthetic organic chemistry-related / Chemical pharmacy Except Principal Investigator Living organism molecular science / Chemical pharmacy
Keywords	Principal Investigator 全合成 / 構造活性相関 / 創薬研究 / 創薬化学 / 合成化学 / フサリシド / 不斉全合成 / 4-pyridone 型 / 2-pyridone 型 / ピラノピリドン … More / フロピリドン / ラジカル環化反応 / 位置選択的なヨード環化反応 / Fusaricide / 創薬 / Pyripyropene A / 新規抗高脂血症薬 / 構造活性相関研究 / ACAT2阻害剤 / ACAT2 / pyripyropene A / ボレリジン / 抗マラリア剤 / Borrelidin / 誘導体合成 / 抗寄生虫薬 / ナフレジン-γ / ナフレジン / NADH-fumarate reductase / 抗寄生虫活性物質 … More Except Principal Investigator ケミカルバイオロジー / ケミカルバイォロジー / 結合タンパク質 / 標的分子 / 天然物 / 感染症 / ACATアイソザイム / 医療・福祉 / 脂質代謝 / ACAT アイソザイム / 動脈硬化症 Less

位置選択的なヨード環化反応を鍵反応とするフサリシドの不斉合成研究Principal Investigator
- Principal Investigator
  
  長光亨
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 33020:Synthetic organic chemistry-related
- Research Institution
  Kitasato University
Synthetic study of habiterpenolPrincipal Investigator
- Principal Investigator
  
  Nagamitsu Tohru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
Total synthesis and structure-activity relationship study of pyripyropene A, a potent and selective ACAT2 InhibitorPrincipal Investigator
- Principal Investigator
  
  NAGAMITSU Tohru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
THE CHEMICAL BIOLOGY OF NEW MICROBIAL ANTI-INFECTIVE AGENTS
- Principal Investigator
  
  TOMODA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kitasato University
Discovery and development of selectivity-defined inhibitors toward two acyl-CoA : cholesterol acyltransferase isozymes
- Principal Investigator
  
  TOMODA Hiroshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
抗マラリア活性物質borrelidinの全合成及び創薬研究Principal Investigator
- Principal Investigator
  
  長光亨
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
特異的な抗寄生虫活性を有するナフレジンの創薬及び生物有機化学的研究Principal Investigator
- Principal Investigator
  
  長光亨
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University

All 2023 2022 2016 2015 2013 2012 2011 2010 2009 2008 2005 2004 Other

All Journal Article Presentation Patent

[Journal Article] Total synthesis of (+)-clavulatriene A2015
- Author(s)
  F. Ito, Y. Ohbatake, S. Aoyama, T. Ikeda, S. Arima, Y. Yamada, H. Ikeda, T. Nagamitsu
- Journal Title
  
  Synthesis
  
  Volume: 47 Issue: 09 Pages: 1348-1355
- DOI
  10.1055/s-0034-1379898
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22108006, KAKENHI-PROJECT-26460013
[Journal Article] Novel Terpenes Generated by Heterologous Expression of Bacterial Terpene Synthase Genes in an Engineered Streptomyces Host2015
- Author(s)
  Yuuki Yamada, Shiho Arima, Tohru Nagamitsu, Kohei Johmoto, Hidehiro Uekusa, Tadashi Eguchi, Kazuo Shin-ya, David E. Cane, Haruo Ikeda
- Journal Title
  
  J. Antibiot.
  
  Volume: 68 Issue: 6 Pages: 385-394
- DOI
  10.1038/ja.2014.171
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22108003, KAKENHI-PLANNED-22108006, KAKENHI-PROJECT-26460013
[Journal Article] Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives2015
- Author(s)
  D. Yamamuro, R. Uchida, M. Ohtawa, S. Arima, Y. Futamura, M. Katane, H. Homma, T. Nagamitsu, H. Osada, H. Tomoda
- Journal Title
  
  Bioorg. Medic. Chem. Lett.
  
  Volume: 25 Issue: 2 Pages: 313-316
- DOI
  10.1016/j.bmcl.2014.11.042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590090, KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-26460013
[Journal Article] Design, synthesis and biological evaluation of air-stable nafuredin-γ analogs as complex II inhibitors.2015
- Author(s)
  Ohtawa, M.; Matsunaga, M.; Fukunaga, K.; Shimizu, R.; Shimizu, E.; Arima, S.; Ohmori, J.; Kita, K.; Shiomi, K.; Omura, S.; Nagamitsu. T.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 5 Pages: 932-943
- DOI
  10.1016/j.bmc.2015.01.030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-26460013
[Journal Article] In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.2015
- Author(s)
  Ohshiro, T.; Matsuda, D.; Ohtawa, M.; Yamazaki, H.; Nagamitsu. T.; Tomoda, H.
- Journal Title
  
  J. Antibiot. 2015, 25, 313-316.
  
  Volume: 68 Issue: 1 Pages: 27-34
- DOI
  10.1038/ja.2014.91
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460152, KAKENHI-PROJECT-26460013, KAKENHI-PROJECT-26253009
[Journal Article] Total Synthesis of Pyripyropene A2011
- Author(s)
  Odani, A.; Ishihara, K.; Ohtawa, M.; Tomoda, H.; Omura, S.; Nagamitsu, T
- Journal Title
  
  Tetrahedron
  
  Volume: Vol. 67, No. 42 Pages: 8159-8203
- URL
  http://dx.doi.org/10.1016/j.tet.2011.06.084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590011
[Journal Article] Total synthesis of amidepsine B and revision of its absolute configuration2009
- Author(s)
  Nagamitsu T, Marumoto K, Nagayasu A, Fukuda T, Arima S, Uchida R, Ohshiro T, Harigaya Y, Tomoda H, Omura S.
- Journal Title
  
  J. Antibiot 62
  
  Pages: 69-74
- NAID
  10030634591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Total synthesis of amidepsine B and revision of its absolute configuration2009
- Author(s)
  T. Nagamitsu, et al.
- Journal Title
  
  J. Antibiot. 62
  
  Pages: 69-74
- NAID
  10030634591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA : cholesterol acyltransferase 2 isozyme2008
- Author(s)
  Ohshiro T, Ohte S, Matsuda D, Ohtawa M, Nagamitsu T, Sunazuka T, Harigaya Y, Rudel LL, Omura S, Tomoda H.
- Journal Title
  
  J. Antibiot 61
  
  Pages: 503-508
- NAID
  10021928313
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390008
[Journal Article] Total synthesis of borrelidin2005
- Author(s)
  Nagamitsu, T.
- Journal Title
  
  Proc.Japan Acad., Ser.B 81
  
  Pages: 244-256
- NAID
  130000093789
- Data Source
  KAKENHI-PROJECT-16790019
[Journal Article] Total synthesis of (-)-Bovrelidin2004
- Author(s)
  Nagamitsu, T.
- Journal Title
  
  Organic Letters 6
  
  Pages: 1865-1867
- Data Source
  KAKENHI-PROJECT-16790019
[Journal Article] Total Synthesis of Borrelidin
- Author(s)
  Tohru Nagamitsu
- Journal Title
  
  Journal of Organic Chemistry (accepted)
- NAID
  130000093789
- Data Source
  KAKENHI-PROJECT-16790019
[Patent] ACAT2阻害活性を示すピリピロペンA構造簡略型誘導体2013
- Inventor(s)
  大多和正樹、大村智、供田洋、長光亨
- Industrial Property Rights Holder
  大多和正樹、大村智、供田洋、長光亨
- Industrial Property Number
  2013-012868
- Filing Date
  2013-01-28
- Data Source
  KAKENHI-PROJECT-22590011
[Patent] ACAT2阻害活性を示す代謝酵素に安定なピリピロペン誘導体2011
- Inventor(s)
  供田洋、長光亨、松田大介、大城太一、大多和正樹、大村智
- Industrial Property Rights Holder
  供田洋、長光亨、松田大介、大城太一、大多和正樹、大村智
- Filing Date
  2011-03-25
- Data Source
  KAKENHI-PROJECT-22590011
[Patent] MRSA産生黄色色素の生成阻害能を示す新規化合物とその用途2011
- Inventor(s)
  供田洋、長光亨、福田隆志、小山信裕
- Industrial Property Rights Holder
  学校法人北里研究所
- Filing Date
  2011-10-12
- Data Source
  KAKENHI-PROJECT-21310146
[Patent] ACAT2阻害活性を示す水酸基含有ピリピロペン誘導体2010
- Inventor(s)
  供田洋、長光亨、松田大介、大城太一、大多和正樹、大村智
- Industrial Property Rights Holder
  供田洋、長光亨、松田大介、大城太一、大多和正樹、大村智
- Filing Date
  2010-06-21
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] 位置選択的なヨード環化反応の開発2023
- Author(s)
  平井潤也、飯塚理駆斗、李大葵、長光亨
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K05099
[Presentation] 位置選択的なヨード環化反応の開発2022
- Author(s)
  平井潤也、飯塚理駆斗、李大葵、長光亨
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K05099
[Presentation] 位置選択的なヨード環化反応の開発2022
- Author(s)
  平井潤也、飯塚理駆斗、李大葵、長光亨
- Organizer
  第12回北里化学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K05099
[Presentation] Hydropyrenolおよびhydropyreneneの合成研究2016
- Author(s)
  大畠由伎, 小松千紘, 池田治生, 長光　亨
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26460013
[Presentation] 新規G2 checkpoint阻害物質habiterpenolの合成研究2016
- Author(s)
  下山健太、長光　亨
- Organizer
  第37回白金シンポジウム
- Place of Presentation
  北里大学薬学部
- Year and Date
  2016-12-20
- Data Source
  KAKENHI-PROJECT-26460013
[Presentation] 新規G2 checkpoint阻害物質habiterpenolの合成研究2016
- Author(s)
  下山健太、内田龍児、供田　洋、長光　亨
- Organizer
  第42回反応と合成の進歩シンポジウム
- Place of Presentation
  静岡市清水文化会館マリナート
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-26460013
[Presentation] Cyslabdanの全合成2015
- Author(s)
  大多和　正樹, 菱沼　祐介, 供田　洋, 長光　亨
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-26460013
[Presentation] Structure-activity relationship study and total synthesis of pyripyropene A as a ACAT2-selective inhibitor2015
- Author(s)
  Ohtawa M, Ohshiro T, Omura S, Tomoda H, Nagamitsu, T
- Organizer
  Pacifichem 2015
- Place of Presentation
  Hawaii, USA
- Year and Date
  2015-12-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460013
[Presentation] Synthesis and biological activity of citridone A and analogs2015
- Author(s)
  Shimoyama K, Fukuda T, Tomoda H, Nagamitsu, T
- Organizer
  Pacifichem 2015
- Place of Presentation
  Hawaii, USA
- Year and Date
  2015-12-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460013
[Presentation] Structure-activity relationship study and total synthesis of pyripyropene A as a ACAT2-selective inhibitor2015
- Author(s)
  Ohtawa, M.; Ohshiro, T.; Omura, S.; Tomoda. H.; Nagamitsu, T.
- Organizer
  The 13th International Kyoto Conference on New Aspects of Organic Chemistry
- Place of Presentation
  京都
- Year and Date
  2015-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460013
[Presentation] Total synthesis of pyripyropene A2012
- Author(s)
  Nagamitsu T
- Organizer
  13th Tetrahedron Symposium - Asia Edition
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2012-11-28
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] 重要疾患に対する化合物ライブラリーの構築に向けた天然物の全合成2012
- Author(s)
  長光亨
- Organizer
  第29回白金シンポジウム
- Place of Presentation
  北里大学薬学部(白金)
- Year and Date
  2012-01-18
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] Pyripyropenene Aの新規低分子誘導体の合成研究2011
- Author(s)
  長光亨
- Organizer
  日本薬学会131年会
- Place of Presentation
  ツインメッセ静岡(静岡)
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] ACAT2選択的阻害剤pyripropene Aの形式全合成2011
- Author(s)
  長光亨
- Organizer
  日本薬学会131年会
- Place of Presentation
  ツインメッセ静岡(静岡)
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] Pyripyropene Aの新規低分子誘導体の合成研究2010
- Author(s)
  長光亨
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] ACAT2選択的阻害剤pyripyropene Aの形式全合成2010
- Author(s)
  長光亨
- Organizer
  第29回メティシナルケミストリーシンポジウム
- Place of Presentation
  京都テルサ(京都)
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] Pyripyropene Aの新規低分子誘導体の合成研究2010
- Author(s)
  長光亨
- Organizer
  第29回メティシナルケミストリーシンポジウム
- Place of Presentation
  京都テルサ(京都)
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] ACAT2選択的阻害剤pyripyropene Aの形式全合成2010
- Author(s)
  長光亨
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京薬科大学
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] ACAT2選択的阻害剤pyripyropene Aの形式全合成2010
- Author(s)
  長光亨
- Organizer
  第60回有機合成化学協会関東支部シンポジウム
- Place of Presentation
  新潟薬科大学新津キャンパス
- Year and Date
  2010-12-05
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] ACAT2 選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関2009
- Author(s)
  大多和正樹、山崎寛之、松田大介、大城太一、針谷義弘、長光亨、大村智、供田洋
- Organizer
  日本薬学会第129年回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] ACAT2 選択的阻害剤pyripyropene Aの誘導体合成と構造活性相関2008
- Author(s)
  大多和正樹、山崎寛之、松田大介、大城太一、針谷義宏、長光亨、大村智、供田洋
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-18390008
[Presentation] Structure-activity relationship of new pyripyropene A derivatives, inhibitors of acyl-CoA:cholesterol acyltranferase 2
- Author(s)
  Ohtawa Masaki（Nagamitsu Tohru）
- Organizer
  13th Tetrahedron Symposium–Asia Edition
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] Total synthesis of pyripyropene A
- Author(s)
  Nagamitsu Tohru
- Organizer
  13th Tetrahedron Symposium–Asia Edition
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] ACAT2選択的阻害剤pyripyropene A構造簡略型誘導体の合成研究
- Author(s)
  寺山富明（長光　亨）
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590011
[Presentation] ACAT2選択的阻害剤pyripyropene Aの全合成および創薬研究
- Author(s)
  大多和正樹（長光　亨）
- Organizer
  第30回白金シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590011

1. TOMODA Hiroshi (70164043)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. INOKOSHI Junji (30151640)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. ISHIBASHI Shun (90212919)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SUNAZUKA Toshiaki (30226592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. UCHIDA Ryuji (60280632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOYAMA Nobuhiro (60439156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. UMEYAMA Hideaki (20050619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHTAWA Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 池田治生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 江口正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 本間浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagamitsu Tohru 長光 亨

長光 亨 ナガミツ トオル

NAGAMITSU Toru 長光 亨

NAGAMITSU Tohru 長光 亨

Research Projects

Research Products

Co-Researchers

位置選択的なヨード環化反応を鍵反応とするフサリシドの不斉合成研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthetic study of habiterpenolPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Total synthesis and structure-activity relationship study of pyripyropene A, a potent and selective ACAT2 InhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE CHEMICAL BIOLOGY OF NEW MICROBIAL ANTI-INFECTIVE AGENTS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery and development of selectivity-defined inhibitors toward two acyl-CoA : cholesterol acyltransferase isozymes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗マラリア活性物質borrelidinの全合成及び創薬研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

特異的な抗寄生虫活性を有するナフレジンの創薬及び生物有機化学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Total synthesis of (+)-clavulatriene A2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Terpenes Generated by Heterologous Expression of Bacterial Terpene Synthase Genes in an Engineered Streptomyces Host2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design, synthesis and biological evaluation of air-stable nafuredin-γ analogs as complex II inhibitors.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.2015

Author(s)

Journal Title

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[Journal Article] Total Synthesis of Pyripyropene A2011

Author(s)

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[Journal Article] Total synthesis of amidepsine B and revision of its absolute configuration2009

Nagamitsu Tohru 長光亨

長光亨ナガミツトオル

NAGAMITSU Toru 長光亨

NAGAMITSU Tohru 長光亨