MAKABE HIDEFUMI 真壁秀文

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MAKABE Hidefumi 真壁秀文

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Researcher Number	90313840
Other IDs	https://orcid.org/0000-0001-9136-6865
Affiliation (Current)	2024: 信州大学, 学術研究院農学系, 教授
Affiliation (based on the past Project Information) *help	2014 – 2023: 信州大学, 学術研究院農学系, 教授 2012 – 2013: 信州大学, 農学研究科, 教授 2007 – 2010: Shinshu University, Graduate Scholl of Agriculture, Associate Professor 2006: 信州大学, 大学院農学研究科, 助教授 2002 – 2005: 信州大学, 大学院・農学研究科, 助教授 2001: 信州大学, 農学研究科・機能性食料開発学専攻, 助教授
Review Section/Research Field	Principal Investigator Bioproduction chemistry/Bioorganic chemistry / Basic Section 38040:Bioorganic chemistry-related / Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry Except Principal Investigator Basic Section 38050:Food sciences-related / Food science
Keywords	Principal Investigator カルボニレーション / 不斉合成 / プロアントシアニジン / ラクトン化 / 生理活性物質 / 天然物 / 生理活性 / 合成化学 / 有機化学 / 抗腫瘍 … More / 分子プローブ / fluorecent probe / antitumor / pyrogallol / proanthocyanidin / ピロガロール基 / 癌転移原因遺伝子 / cancer metastasis / pyrogallol group / antituor / proanthocyaidin / 蛍光プローブ / 縮合反応 / ルイス酸 / 天然物合成 / ポリフェノール / プロシアニジン / イソクマリン / biological activity / synthetic chemistry / organic chemistry / 生物活性物質 / ピペリジンアリカロイド / オキシパラデーション / ピペリジンアルカロイド / アミノパラデーション / 炎症抑制 / Cyathane / スーパーオキサイド / 全合成 / 活性酸素 … More Except Principal Investigator ガレート / 炎症 / プロシアニジン / 皮膚炎 / 抗炎症作用 / TLR7 / 樹状細胞 / エネルギー代謝 / 免疫調節 / 解糖系 / サイトカイン / T細胞 / Hsp70 / 神経細胞保護効果 / 老化促進モデルマウス / 認知能力 / 神経細胞 / アストロサイト / フェルラ酸 / 神経新生 / BDNF / 神経栄養因子 / 神経変性疾患 / 配糖体 Less

Synthesis of proanthocyanidins which posess pyrogaloll moiety and elucidation of mechanissm of action for anti-tumor activityPrincipal Investigator
- Principal Investigator
  
  真壁秀文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Shinshu University
プロシアニジンガレートによるTLR7制御メカニズムの解明と皮膚炎予防効果の検証
- Principal Investigator
  
  田中沙智
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Shinshu University
Inhibitory effect of procyanidins on chronic inflammation through immune-metabolic regulation
- Principal Investigator
  
  Tanaka Sachi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Shinshu University
Chemeicalbiological studies on proanthocyanidins which supress metastasis and invasion of cancerPrincipal Investigator
- Principal Investigator
  
  Makabe Hidefumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Shinshu University
Synthetic studies on bioactive compounds using palladium catalyzed CO insertionPrincipal Investigator
- Principal Investigator
  
  Makabe Hidefumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Shinshu University
Enzymatic synthesis of novel rutinoside and its neuroprotective properties
- Principal Investigator
  
  Katayama Shigeru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Shinshu University
Synthetic studies on bioactive compounds using Pd-catalyzed stereoselective cyclizationPrincipal Investigator
- Principal Investigator
  
  MAKABE Hidefumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Shinshu University
Synthetic and bioorganic studies on sarcodoninsPrincipal Investigator
- Principal Investigator
  
  MAKABE Hidefumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Shinshu University
Systematic Synthetic Stuchies on Bioactive Alkaloids and Their Biokeical ActiviiiesPrincipal Investigator
- Principal Investigator
  
  MAKABE Hidefumi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Shinshu University
Cyathane骨格を持つ天然有機化合物の合成と生物有機化学的研究Principal Investigator
- Principal Investigator
  
  真壁秀文
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Shinshu University
スーパーオキサイド産生抑制物質spectamine類の合成と生物有機化学研究Principal Investigator
- Principal Investigator
  
  真壁秀文
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Shinshu University

[Journal Article] Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in murine CD4+ T cells through the regulation of glutamine influx via direct interaction with ASCT22023
- Author(s)
  Endo K, Sawa T, Kitamura H, Umezawa K, Makabe H, Tanaka S.
- Journal Title
  
  International Immunopharmacology
  
  Volume: 115 Pages: 109617-109617
- DOI
  10.1016/j.intimp.2022.109617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K05524, KAKENHI-PROJECT-23KJ1039
[Journal Article] Procyanidin B2 3,3′′-di-O-gallate ameliorates imiquimod-induced skin inflammation by suppressing TLR7 signaling through the inhibition of endosomal acidification in dendritic cells2023
- Author(s)
  Sawa Toko、Endo Katsunori、Nakashima Akane、Tanaka Yuna、Makabe Hidefumi、Tanaka Sachi
- Journal Title
  
  International Immunopharmacology
  
  Volume: 121 Pages: 110444-110444
- DOI
  10.1016/j.intimp.2023.110444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23KJ1039, KAKENHI-PROJECT-22K05524
[Journal Article] Concise Synthesis of Procyanidin B23,3''-digallate Using Yb(OTf)_3 Mediated Self-Condensation2022
- Author(s)
  Tanaka, Y.; Kobayashi, S.; Hattori, Y.; Kawamura, A.; Makabe, H.
- Journal Title
  
  Synlett
  
  Volume: 33 Pages: 1071-1074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05454
[Journal Article] Synthesis of(+)-Muconin via Diastereoselective Oxypalladation2021
- Author(s)
  Sugimoto, M.; Nosho, S.; Hikosaka, G.; Hattori, Y.; Umezawa, K.; Kawamura, A.; Makabe, H.
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 86 Issue: 6 Pages: 4859-4866
- DOI
  10.1021/acs.joc.0c02831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580160
[Journal Article] The suppression of IL-17 production from T cells by gallate-type procyanidin is mediated by selectively inhibiting cytokine production from dendritic cells2021
- Author(s)
  Endo K, Matsui R, Asami T, Sawa T, Nakashima A, Tanaka Y, Makabe H, Tanaka S.
- Journal Title
  
  Biomedical Pharmacotherapy
  
  Volume: 137 Pages: 111346-111346
- DOI
  10.1016/j.biopha.2021.111346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05893
[Journal Article] Synthesis of(+)-solenopsin via Pd-catalyzed N-Alkylation and Cyclization2021
- Author(s)
  Suzuki, K.; Hattori, Y.; Kawamura, A.; Makabe, H.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 85 Issue: 2 Pages: 223-227
- DOI
  10.1093/bbb/zbaa014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580160
[Journal Article] Procyanidin B2 gallate regulates TNF-α production from T cells through inhibiting glycolytic activity via mTOR-HIF-1 pathway.2020
- Author(s)
  Endo K, Matsui R, Sugiyama M, Asami T, Inaba C, Kobayashi S, Makabe H, Tanaka S
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 177 Pages: 113952-113952
- DOI
  10.1016/j.bcp.2020.113952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05893
[Journal Article] Kale supplementation up-regulates HSP70 and suppresses cognitive decline in a mouse model of accelerated senescence2018
- Author(s)
  Kushimoto Shoko、Uchibori Yuki、Yanai Shuichi、Makabe Hidefumi、Nakamura Soichiro、Katayama Shigeru
- Journal Title
  
  Journal of Functional Foods
  
  Volume: 44 Pages: 292-298
- DOI
  10.1016/j.jff.2018.03.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07426, KAKENHI-PROJECT-18K07460, KAKENHI-PROJECT-16H03288
[Journal Article] An asymmetric synthesis of(+)-monomorine I2017
- Author(s)
  Asai, M.; Takemoto, Y.; Deguchi, A.; Hattori, Y.; Makabe, H.
- Journal Title
  
  Tetrahedron : Asymmetry
  
  Volume: 28 Issue: 11 Pages: 1582-1586
- DOI
  10.1016/j.tetasy.2017.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580160
[Journal Article] Synthesis of Isocoumarin Compounds, 8-Hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one and Fusariumin Analog Using Palladium-catalyzed Carbonylation Trapping with O-Enolate2017
- Author(s)
  Asai, M.; Hattori, Y.; Makabe, H.
- Journal Title
  
  Heterocycles
  
  Volume: 94 Issue: 8 Pages: 1542-1553
- DOI
  10.3987/com-17-13746
- NAID
  120007099633
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07408
[Journal Article] Synthesis of legioliulin, a fluorescent isocoumarin compound, isolated from Legionella dumoffii using cyclic acylpalladation and Heck reaction2016
- Author(s)
  Asai, M.; Hattori, Y.; Makabe, H.
- Journal Title
  
  Tetrahedrn Letters
  
  Volume: 57 Issue: 35 Pages: 3942-3944
- DOI
  10.1016/j.tetlet.2016.07.064
- NAID
  120007099651
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07408
[Journal Article] Synthesis of decytospolide A, B and their C-3 epimers using stereoselective oxypalladation2016
- Author(s)
  Kurogome, Y.; Hattori, Y.; Makabe, H.
- Journal Title
  
  Synthesis
  
  Volume: 48 Pages: 765-771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580160
[Journal Article] Synthesis of both enantiomer of akolactone B and (+)-ancepsenolid2014
- Author(s)
  Hikosaka, G.; Hattori, Y.; Makabe H.
- Journal Title
  
  Tetrahedron: Asymmetry
  
  Volume: 25 Issue: 20-21 Pages: 1367-1371
- DOI
  10.1016/j.tetasy.2014.08.008
- NAID
  120007106218
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24580160
[Journal Article] Synthesis of (+)-boronolide and (+)-deacetylboronolide using Pd-catalyzed carbonylation and lactonization2014
- Author(s)
  Kurogome, Y.; Hattori, Y.; Makabe, H.
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 55 Issue: 17 Pages: 2822-2824
- DOI
  10.1016/j.tetlet.2014.03.070
- NAID
  120007106210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580160
[Journal Article] Synthesis of four diastereomers and structural revision of tetradenolide2014
- Author(s)
  Tokuda, M.; Kurogome, Y.; Katoh, R.; Nohara, Y.; Hattori, Y.; Makabe, H.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 55 Issue: 30 Pages: 4189-4192
- DOI
  10.1016/j.tetlet.2014.05.109
- NAID
  120007106219
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24580160
[Journal Article] Total synthesis of (+)-azimine via diastereoselective aminopalladation2013
- Author(s)
  Kurogome, Y.; Kogiso, M.; Looi, K. K.; Hattori, Y.; Konno, H.; Hirota, M.; Makabe, H.
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Issue: 39 Pages: 8349-8352
- DOI
  10.1016/j.tet.2013.07.083
- NAID
  120007106213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580160, KAKENHI-PROJECT-25450145
[Journal Article] Synthesis of Pyranicin and Its Inhibitory Action with Bovine Heart Mitochondria Complex I2008
- Author(s)
  Hattori, Y., Furuhata, S., Okajima, M., Konno, H., Abe, M., Miyoshi, H., Goto, T., Makabe, H
- Journal Title
  
  Organic Letters 10
  
  Pages: 717-720
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Journal Article] Synthesis of Pyranicin and Its Inhibitory Action with Bovine Heart Mitochondrial Complex I2008
- Author(s)
  Hattori, Y.; Furuhata, S.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H.
- Journal Title
  
  Organic Letters 10
  
  Pages: 717-720
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580104
[Journal Article] Synthesis, determination of the absolute configuration of tookinelin, and inhibitory action with bovine heart mitochondrial complex I2007
- Author(s)
  Hattori, Y.; Konno, H.; Abe, M,; Miyoshi, H.; Goto, T.; Makabe, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry 15
  
  Pages: 3026-3031
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580104
[Journal Article] Synthesis, determination of the absolute configuration of tonkinelin, and inhibitory action with bovine heart mitochondrial complex I2007
- Author(s)
  Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry 15
  
  Pages: 3026-3031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580104
[Journal Article] Synthesis, determination of the absolute configuration of tonkinelin, and inhibitory action with bovine heart mitochondrial complex I2007
- Author(s)
  Hattori, Y., Konno, H., Abe, M., Miyoshi, H., Goto, T., Makabe, H
- Journal Title
  
  Bioorganic & Medicinal Chemistry 15
  
  Pages: 3026-3031
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Journal Article] Synthesis of(4R,15R,16R,21S)-and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I2006
- Author(s)
  Makabe, H., Kimura, Y., Higuchi, M., Konno, H., Murai, M., Miyoshi, H
- Journal Title
  
  Bioorg.Med.Chem. 14
  
  Pages: 3119-3130
- Data Source
  KAKENHI-PROJECT-15780084
[Journal Article] Synthesis of(4R,15R,16R,21S)-and(4R,15R,16S,21R)-rollicosin2005
- Author(s)
  Makabe, H., Higuchi, M., Konno, H., Murai, M., Miyoshi, H.
- Journal Title
  
  Tetrahedron Lett 46
  
  Pages: 4671-4675
- Data Source
  KAKENHI-PROJECT-15780084
[Journal Article] Anti-inflammatory cyathane Diterpenoids from Sarcodon scabrosus2004
- Author(s)
  Kamo, T., Imura, Y., Hagio, T., Makabe, H., Shibata, H., Hirota, M
- Journal Title
  
  Biosci.Biotechnol.Biochem. 68
  
  Pages: 1362-1365
- NAID
  10013286909
- Data Source
  KAKENHI-PROJECT-15780084
[Patent] エピガロカテキンを含むオリゴマーおよびその製造方法2022
- Inventor(s)
  真壁秀文、藤井博
- Industrial Property Rights Holder
  信州大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-18K05454
[Patent] ガレート型エピカテキン重合体又はガレート型エピガロカテキン重合体の製造方法2021
- Inventor(s)
  真壁秀文、田中友梨
- Industrial Property Rights Holder
  信州大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-099104
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-18K05454
[Presentation] プロアントシアニジン類蛍光プローブの合成研究2022
- Author(s)
  小林周平, 河村篤, 真壁秀文
- Organizer
  日本農芸化学会2022年大会(京都)
- Data Source
  KAKENHI-PROJECT-18K05454
[Presentation] Procyanidin B2 3,3″-di-O-gallateのASCT2との結合を介したグルタミン取り込み阻害によるT細胞機能制御2022
- Author(s)
  遠藤勝紀、澤陶有子、田中佑奈、齋木建、芳賀葉月、真壁秀文、田中沙智
- Organizer
  日本食品免疫学会第18回学術大会
- Data Source
  KAKENHI-PROJECT-22K05524
[Presentation] 樹状細胞のTLRシグナルを介したサイトカイン産生に対するガレート型プロシアニジンの影響2022
- Author(s)
  澤陶有子、遠藤勝紀、田中佑奈、齋木健、芳賀葉月、真壁秀文、田中沙智
- Organizer
  日本食品免疫学会第18回学術大会
- Data Source
  KAKENHI-PROJECT-22K05524
[Presentation] ガレート型プロシアニジンがT細胞のアミノ酸代謝に及ぼす影響2022
- Author(s)
  遠藤勝紀、澤陶有子、真壁秀文、田中沙智
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-19K05893
[Presentation] 2, 6-2置換ピペリジン環の立体選択的な構築法の開発と(+)-solenopsinの合成2021
- Author(s)
  真壁秀文, 鈴木香名, 河村篤, 服部恭尚
- Organizer
  日本農芸化学会2021年大会(仙台)
- Data Source
  KAKENHI-PROJECT-24580160
[Presentation] ガレート型プロシアニジンによるIL-17産生抑制メカニズムの解析2021
- Author(s)
  遠藤勝紀、澤陶有子、真壁秀文、田中沙智
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K05893
[Presentation] Procyanidin B2 gallateのmTOR経路を介したT細胞機能制御2020
- Author(s)
  遠藤勝紀、松井莉奈、杉山李奈、浅見拓哉、稲葉千尋、真壁秀文、田中沙智
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19K05893
[Presentation] PCB2DGによる解糖系を介したT細胞機能制御メカニズムの解明2020
- Author(s)
  遠藤勝紀、松井莉奈、浅見拓哉、真壁秀文、田中沙智
- Organizer
  日本農芸化学会中部支部例会第187回例会
- Data Source
  KAKENHI-PROJECT-19K05893
[Presentation] パラジウム触媒による環化反応を用いた(+)-muconinの合成研究2020
- Author(s)
  杉本誠、納所早弥華、彦坂源、服部恭尚、真壁秀文
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-24580160
[Presentation] がん転移促進遺伝子を標的とした抗腫瘍性分子の探索と作用機序の解析2019
- Author(s)
  野々部修平，戸田和弥，松本桐子，川口耕一郎，轟拓磨，梅澤公二，真壁秀文，藤井博
- Organizer
  第42回日本分子生物学会，2019年12月3日，マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-18K05454
[Presentation] ブドウ梗に含まれる proanthocyanidin 類の合成2018
- Author(s)
  野田礼子，森雅貴，河原誠一 , 服部恭尚，藤井博，真壁秀文
- Organizer
  日本農芸化学会中部支部第 183 回例会
- Data Source
  KAKENHI-PROJECT-18K05454
[Presentation] エピガロカテキン重合体の合成研究2018
- Author(s)
  山本慎也，市川幹広，石原知里，野々部修平，服部恭尚，梅澤公二，藤井博，真壁秀文
- Organizer
  第60回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18K05454
[Presentation] 立体選択的なアミノパラデーションを用いた(-)-isosolenopsinと(+)-monomorineの合成研究2017
- Author(s)
  武本夕貴子、服部恭尚、真壁秀文
- Organizer
  日本農芸化学会2017年大会(京都)
- Data Source
  KAKENHI-PROJECT-24580160
[Presentation] パラジウム触媒を用いた環化反応によるピペリジンアルカロイドとイソクマリン化合物の合成研究2017
- Author(s)
  浅井将貴，武本夕貴子，服部恭尚，真壁秀文
- Organizer
  第59回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-15K07408
[Presentation] Pd触媒による一酸化炭素挿入を用いたイソクマリン化合物legioliulinの合成研究2016
- Author(s)
  浅井将貴，服部恭尚，真壁秀文
- Organizer
  日本農芸化学会中部支部第177回例会
- Place of Presentation
  名古屋大学（愛知県　名古屋市）
- Year and Date
  2016-09-24
- Data Source
  KAKENHI-PROJECT-15K07408
[Presentation] 立体選択的oxypalladationを用いたdecytospolide Bの合成研究2015
- Author(s)
  黒米雄次，真壁秀文
- Organizer
  日本農芸化学会2015年度大会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-24580160
[Presentation] 立体選択的oxypalladationを用いたdecytospolide A, Bおよび3-epi体の合成研究2015
- Author(s)
  黒米雄次、服部恭尚、真壁秀文
- Organizer
  2015年度日本農芸化学会中部・関西合同支部会(富山)
- Data Source
  KAKENHI-PROJECT-24580160
[Presentation] Tetradenolideの4つのジアステレオマーの合成と構造訂正2014
- Author(s)
  徳田真樹，黒米雄次，加藤理恵子，野原由江，服部恭尚，真壁秀文
- Organizer
  日本農芸化学会2014年大会
- Place of Presentation
  川崎市　明治大学
- Data Source
  KAKENHI-PROJECT-24580160
[Presentation] Pd 触媒によるカルボニレーションを用いたα,β-不飽和-γ-ラクトン環を有する天然物の合成2014
- Author(s)
  彦坂源，服部恭尚，真壁秀文
- Organizer
  日本農芸化学会中部支部第171回例会
- Place of Presentation
  名古屋大学
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-24580160
[Presentation] Deacetylboronolideの合成研究2014
- Author(s)
  黒米雄次，徳田真樹，服部恭尚，真壁秀文
- Organizer
  日本農芸化学会2014年大会
- Place of Presentation
  川崎市　明治大学
- Data Source
  KAKENHI-PROJECT-24580160
[Presentation] 立体選択的なアミノパラデーションを用いたピペリジンアリカロイド(-)-cassineおよび(+)-azimineの合成2013
- Author(s)
  黒米雄次，小木曽将也，雷国光，服部恭尚，今野博行，廣田満，真壁秀文
- Organizer
  第55回天然有機化合物討論会
- Place of Presentation
  京都市　同志社大学
- Data Source
  KAKENHI-PROJECT-24580160
[Presentation] Sarcodonin Aの14-deoxy体への変換とその炎症抑制活性2010
- Author(s)
  鹿島温, 真壁秀文, 廣田満
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20580110
[Presentation] Sarcodonin Aの14-deoxy体への変換とその炎症抑制活性2010
- Author(s)
  鹿島温, 真壁秀文, 廣田満
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京大学
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20580110
[Presentation] Sarcodonin類の構造と炎症抑制活性2009
- Author(s)
  鹿島温, 森有未, 廣田満, 真壁秀文
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-20580110
[Presentation] Spectamine Aの合成研究2008
- Author(s)
  毛利圭宏, 服部恭尚, 真壁秀文
- Organizer
  農芸化学会2008年度大会
- Place of Presentation
  名城大学(名古屋)
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthetic studies on spectamine A2008
- Author(s)
  Mohri, Y., Hattori, Y., Makabe, H
- Organizer
  Annual Meeting of JSBBA 2008
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2008-03-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Pyranicinの合成とミトコンドリアcomplex I阻害活性2008
- Author(s)
  古畑真一, 服部恭尚, 今野博行, 安部真人, 三芳秀人, 後藤哲久, 真壁秀文
- Organizer
  農芸化学会2008年度大会
- Place of Presentation
  名城大学(名古屋)
- Year and Date
  2008-03-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Pyranicinの合成とミトコンドリアcomplex I阻害活性2008
- Author(s)
  古畑真一, 服部恭尚, 今野博行, 安部真人, 三芳秀人, 後藤哲久, 真壁秀文
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  名城大学(名古屋)
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Spectamine Aの合成研究2008
- Author(s)
  毛利圭宏, 服部恭尚, 真壁秀文
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  名城大学(名古屋)
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthesis of pyranicin and its inhibitory action of mitochondrial complex I2008
- Author(s)
  Furuhata, S., Hattori, Y., Konno, H., Abe, M., Miyoshi, It ; Goto, T., Makabe, H
- Organizer
  Annual Meeting of JSBBA 2008
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2008-03-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthetic studies on chamuvarinin2007
- Author(s)
  Sagehashi, M., Hattori, Y., Konno, H., Makabe, H
- Organizer
  Kansai-Tyubu Unified Meeting of JSBBA 2007
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2007-09-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthetic studies on pyranicin2007
- Author(s)
  Furuhata, S., Hattori, Y., Konno, H., Goto, T., Makabe, H
- Organizer
  Kansai-Tyubu Unified Meeting of JSBBA 2007
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2007-09-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Development of Pd Catalyzed Stereoselective Cyclization and Its Application for the Synthesis of Natural Products2007
- Author(s)
  Hattori, Y.; Furuhata, S.; Mohri, Y.; Makabe, H.
- Organizer
  4th Asia-Pacific Conference on Chemical Ecology
- Place of Presentation
  エポカルつくば(つくば)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthesis of Pyranicin via Pd(111) Catalyzed Diastereoselective Cyclization2007
- Author(s)
  Hattori, Y., Furuhata, S., OKajima, M., Konno, IL, Goto, T., Makabe, H
- Organizer
  14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
- Place of Presentation
  Nara, Japan
- Year and Date
  2007-08-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthesis of Pyranicin via Pd(II) Catalyzed Diastereoselective Cyclization2007
- Author(s)
  Hattori, Y.; Furuhata, S.; Okajima, M.; Konno, H.; Goto, T.; Makabe, H.
- Organizer
  14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
- Place of Presentation
  奈良
- Year and Date
  2007-08-03
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Development of Pd Catalyzed Stereoselective Cyclization and Its Application for the Synthesis of Natural Products2007
- Author(s)
  Hattori, Y., Furuhata, S., Mohri, Y., Makabe, H
- Organizer
  4th Asia-Pacific Conference on Chemical Ecology
- Place of Presentation
  Tsukuba, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] バンレイシ科アセトゲニンpyranicinの合成研究2007
- Author(s)
  古畑真一, 服部恭尚, 今野博行, 後藤哲久, 真壁秀文
- Organizer
  日本農芸化学会2007年度関西・中部支部合同大会
- Place of Presentation
  中部大学(名古屋)
- Year and Date
  2007-09-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] バンレイシ科アセトゲニン,pyranicinの合成研究2007
- Author(s)
  古畑真一, 服部恭尚, 後藤哲久, 真壁秀文
- Organizer
  農芸化学会2007年度大会
- Place of Presentation
  東京農業大学(東京)
- Year and Date
  2007-03-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthesis of annonaceous acetogenin, pyranicin2007
- Author(s)
  Furuhata, S., Hattori, Y., Goto, T., Makabe, Goto, T., Makabe, H
- Organizer
  147th Chubu Region Meeting of JSBBA
- Place of Presentation
  Nagoya, Japan
- Year and Date
  2007-10-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthesis of Pyranicin via Pd(II)Catalyzed Diastereoselective Cyclization2007
- Author(s)
  Hattori, Y.; Furuhata, S.; Okajima, M.; Konno, H.; Goto, T.; Makabe, H.
- Organizer
  14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
- Place of Presentation
  奈良センテニアルホール(奈良)
- Year and Date
  2007-08-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] バンレイシ科アセトゲニンchamuvarininの合成研究2007
- Author(s)
  提箸正義, 服部恭尚, 今野博行, 真壁秀文
- Organizer
  日本農芸化学会2007年度関西・中部支部合同大会
- Place of Presentation
  中部大学(名古屋)
- Year and Date
  2007-09-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthesis of annonaceous acetogenin, pyranicin2007
- Author(s)
  Furuhata, S., Hattori, Y., Goto, T., Makabe, Goto, T., Makabe, H
- Organizer
  Annual Meeting of JSBBA 2008
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2007-03-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Pd触媒による六員環形成反応を用いたピペリジンアルカロイド(-)-cassine, spectamine Aおよびバンレイシ科アセトゲニンpyranicinの合成研究2006
- Author(s)
  服部恭尚, 古畑真一, 松本若菜, 雷国光, 今野博行, 加茂綱嗣, 廣田満後藤哲久, 真壁秀文
- Organizer
  第48回天然有樹化合物討論会
- Place of Presentation
  仙台国際センター(仙台)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] Synthetic studies on 2,6-disubstituted piperidine alkaroids, (-)-cassine and spectamine A and annonaceous acetogenin, pyranicin via palladium catalyzed six-membered ring formation2006
- Author(s)
  Hattori, Y., Furuhata, S., Matsumoto, W., Kong, L. K., Konno, IL, Kamo, T., Hirota, M., Goto, T., Makabe, H
- Organizer
  48th Symposium on the Chemistry of Natural Products
- Place of Presentation
  Sendai, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580104
[Presentation] バンレイシ科アセトゲニン,pyranicinの合成研究2006
- Author(s)
  古畑真一, 服部恭尚, 後藤哲久, 真壁秀文
- Organizer
  日本農芸化学会中部支部第147会例会
- Place of Presentation
  名古屋大学(名古屋)
- Year and Date
  2006-10-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18580104

1. Tanaka Sachi (90633032)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. HIROTA Mitsuru (90199133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. FUJII HIROSHI (90165340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Katayama Shigeru (30443922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Furuya Shigeki (00222274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 梅澤公二 (00609258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

MAKABE HIDEFUMI 真壁 秀文

MAKABE Hidefumi 真壁 秀文

Research Projects

Research Products

Co-Researchers

Synthesis of proanthocyanidins which posess pyrogaloll moiety and elucidation of mechanissm of action for anti-tumor activityPrincipal Investigator

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プロシアニジンガレートによるTLR7制御メカニズムの解明と皮膚炎予防効果の検証

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Inhibitory effect of procyanidins on chronic inflammation through immune-metabolic regulation

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Chemeicalbiological studies on proanthocyanidins which supress metastasis and invasion of cancerPrincipal Investigator

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Synthetic studies on bioactive compounds using palladium catalyzed CO insertionPrincipal Investigator

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Enzymatic synthesis of novel rutinoside and its neuroprotective properties

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Synthetic studies on bioactive compounds using Pd-catalyzed stereoselective cyclizationPrincipal Investigator

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Synthetic and bioorganic studies on sarcodoninsPrincipal Investigator

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Systematic Synthetic Stuchies on Bioactive Alkaloids and Their Biokeical ActiviiiesPrincipal Investigator

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Cyathane骨格を持つ天然有機化合物の合成と生物有機化学的研究Principal Investigator

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スーパーオキサイド産生抑制物質spectamine類の合成と生物有機化学研究Principal Investigator

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[Journal Article] Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in murine CD4+ T cells through the regulation of glutamine influx via direct interaction with ASCT22023

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[Journal Article] Procyanidin B2 3,3′′-di-O-gallate ameliorates imiquimod-induced skin inflammation by suppressing TLR7 signaling through the inhibition of endosomal acidification in dendritic cells2023

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MAKABE HIDEFUMI 真壁秀文

MAKABE Hidefumi 真壁秀文