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UCHIBA MITSUHIRO  内場 光浩

… Alternative Names

UCHIBA Mitsuhiro  内場 光浩

内場 光浩  ウチバ ミツヒロ

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Researcher Number 90315292
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3377-4216
Affiliation (Current) 2025: 熊本大学, 病院, 講師
Affiliation (based on the past Project Information) *help 2024: 熊本大学, 病院, 講師
2005 – 2006: 熊本大学, 医学部付属病院, 助手
2003 – 2005: 熊本大学, 医学部附属病院, 助手
2001: 熊本大学, 医学部・附属病院, 助手
2000: 熊本大学, 医学部・付属病院, 助手
Review Section/Research Field
Principal Investigator
Emergency medicine / Hematology
Except Principal Investigator
Emergency medicine / Basic Section 55010:General surgery and pediatric surgery-related / Biological Sciences
Keywords
Principal Investigator
CGRP / プロスタサイクリン / denervation / activated leukocyte / knockout mouse / gastric mucosal injury / sensory neurons / gender / 卵巣摘出 / カルシトニン遺伝子関連ペプチド … More / 水浸拘束ストレス / カルシトニン遺伝子関連ペプチ / 除神経 / 活性化白血球 / ノックアウトマウス / 胃粘膜傷害発症 / 知覚神経 / 性差 / CREB / ICAM-1 / サイクリックAMP / 組織壊死因子 / 血管内皮細胞 / E-セレクチン / アンチトロンビン … More
Except Principal Investigator
CGRP / iNOS / アンチトロンビン / CD42b / 肝細胞 / 脱シアル化血小板 / Apoptosis / Insulin-like growth factor-I / sensory neurons / Severe sepsis / Reperfusion-induced tissue injury / Antithrombin / 敗血症 / 臓器保護 / アポトーシス / インスリン様成長因子-I / 知覚神経 / 重症敗血症 / 虚血再灌流 / endotoxin / Nitric oxide / Septic shock / prostacyclin / capsaicin sensitive sensory neurons / tumor necrosis factor / カプサイシン知覚神経 / エンドトキシン / 一酸化窒素 / 敗血症性ショック / プロスタグランディン / カプサイシン感受性知覚神経 / 腫瘍壊死因子 / カルシトニン遺伝子関連ペプチド / 活性化プロテインC / トロンボモジュリン / 血液凝固 / 免疫学 / 生体分子 / 細菌 / 感染症 Less
  • Research Projects

    (6 results)
  • Research Products

    (45 results)
  • Co-Researchers

    (4 People)
  •  老化血小板を用いた肝疾患における新規治療法確立を目指した基礎研究

    • Principal Investigator
      登尾 一平
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Kumamoto Health Science University
  •  Possible therapeutic application of ntithrombin in severe sepsis

    • Principal Investigator
      OKAJIMA Kenji
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      NAGOYA CITY UNIVERSITY
  •  Role of sensory neurons to gender difference in the responses against stress.Principal Investigator

    • Principal Investigator
      UCHIBA Mitsuhiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Kumamoto University
  •  Regulation of septic shock by carcitonin-gene related peptide

    • Principal Investigator
      OKAJIMA Kenji
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Kumamoto University
  •  生理的抗凝固物質による感染宿主炎症応答制御の分子機構の解析

    • Principal Investigator
      OKAJIMA Kenji
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  アンチトロンビンの血管内皮細胞および単球の活性化抑制作用の解析Principal Investigator

    • Principal Investigator
      内場 光浩
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University

All 2006 2005 2004 2003

All Journal Article

  • [Journal Article] Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells.2006

    • Author(s)
      Kurata M, Okajima K, Kawamoto T, Uchiba M, Ohkohchi N.
    • Journal Title

      World J Gastroenterol. 12(1)

      Pages: 60-65

    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.2006

    • Author(s)
      Harada N, Okajima K, Uchiba M.
    • Journal Title

      Crit Care Med. Apr 25

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Dalteparin, a low molecular weight heparin, attenuates inflammatory responses and reduces ischemia-reperfusion-induced liver injury in rats.2006

    • Author(s)
      Harada N, Okajima K, Uchiba M.
    • Journal Title

      Crit Care Med. (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Antithrombin reduces reperfusion-induced liver injury in mice by enhancing sensory neuron activation.2006

    • Author(s)
      Harada N, Okajima K, Uchiba M, Kurihara H, Nakagata N.
    • Journal Title

      Thromb Haemost. 95

      Pages: 788-95

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells.2006

    • Author(s)
      Kurata M, Okajima K, Kawamoto T, Uchiba M, Ohkohchi N.
    • Journal Title

      World J Gastroenterol. 12

      Pages: 60-5

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-alpha production through inhibition of Egr-1 expression.2005

    • Author(s)
      Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Okabe H
    • Journal Title

      Am J Physiol Heart Circ Physiol 288

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-alpha production through inhibition of Egr-1 expression.2005

    • Author(s)
      Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Okabe H.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 288

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Role of sensory neuron in reduction of endotoxin-induced hypotension in rats.2005

    • Author(s)
      Okajima K, Isobe H, Uchiba M, Harada N.
    • Journal Title

      Crit Care Med. 33

      Pages: 847-54

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Inhibition of lipopolysaccharide-induced tissue factor expression in monocytes by urinary trypsin inhibitor in vitro and in vivo.2005

    • Author(s)
      Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Shimozawa N, Okabe H.
    • Journal Title

      Thromb Haemost. 94

      Pages: 136-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Inhibition of lipopolysaccharide-induced tissue factor expression in monocytes by urinary trypsin inhibitor in vitro and in vivo.2005

    • Author(s)
      Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Shimozawa N, Okabe H.
    • Journal Title

      Thromb Haemost. 94(1)

      Pages: 136-145

    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-alpha production through inhibition of Egr-l expression.2005

    • Author(s)
      Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Okabe H.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 288

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Role of sensory neuron in reduction of endotoxin-induced hypotension in rats.2005

    • Author(s)
      Okajima K, Isobe H, Uchiba M, Harada N.
    • Journal Title

      Crit Care Med 33(4)

      Pages: 847-854

    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-alpha production through inhibition of Egr-1 expression.2005

    • Author(s)
      Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Okabe H.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 288

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Inhibition of lipopolysaccharide-induced tissue factor expression in monocytes by urinary trypsin inhibitor in vitro and in vivo.2005

    • Author(s)
      Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, shimozawa N, Okabe H.
    • Journal Title

      Thromb Haemost. 94

      Pages: 136-45

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Urinary trypsin inhibitor reduces LPS-induced hypotension by suppressing tumor necrosis factor-alpha production through inhibition of Egr-1 expression.2005

    • Author(s)
      Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Okabe H
    • Journal Title

      Am J Physiol Heart Circ Physiol 288

    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Inhibition of the endothelial cell activation by antithrombin in vitro.2004

    • Author(s)
      Uchiba M, Okajima K, Kaun C, Wojta J, Binder BR
    • Journal Title

      Thromb Haemost 92

      Pages: 1420-1427

    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Antithrombin reduces compression-induced spinal cord injury in rats.2004

    • Author(s)
      Taoka Y, Okajima K, Uchiba M.
    • Journal Title

      J Neurotrauma. 21

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1.2004

    • Author(s)
      Harada N, Okajima K, Uchiba M, Kushimoto S, Isobe H.
    • Journal Title

      Thromb Haemost. 92

      Pages: 550-8

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective beta-blocker, in spontaneous hypertensive rats.2004

    • Author(s)
      Okajima K, Harada N, Uchiba M, Isobe H.
    • Journal Title

      J Pharmacol Exp Ther. 309

      Pages: 684-91

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.2004

    • Author(s)
      Uchiba M, Okajima K, Oike Y, Tto Y, Fukudome K, Isobe H, Suda T.
    • Journal Title

      Circ Res. 95

      Pages: 34-41

    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1.2004

    • Author(s)
      Harada N, Okajima K, Uchiba M, Kushimoto S, Isobe H.
    • Journal Title

      Thromb Haemost. 92

      Pages: 550-558

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.2004

    • Author(s)
      Uchiba M, Okajima K, Oike Y, Ito Y, Fukudome K, Isobe H, Suda T.
    • Journal Title

      Circ Res. 95

      Pages: 34-41

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Inhibition of the endothelial cell activation by antithrombin in vitro.2004

    • Author(s)
      Uchiba M, Okajima K, Kaun C, Wojta J, Binder BR.
    • Journal Title

      Thromb Haemost 92

      Pages: 1420-1427

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.2004

    • Author(s)
      Uchiba M, Okajima K, Oike Y, Ito Y, Fukudome K, Isobe H, Suda T.
    • Journal Title

      Circ Res. 95

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Activation of capsaicin-sensitive sensory neurons by carvedilol, a nonselective {beta}-blocker, in spontaneous hypertensive rats.2004

    • Author(s)
      Okajima K, Harada N, Uchiba M, Isobe H.
    • Journal Title

      J Pharmacol Exp Ther. 309

      Pages: 684-691

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.2004

    • Author(s)
      Okajima K, Harada N, Uchiba M, Mori M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 287

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Antithrombin reduces compression-induced spinal cord injury in rats.2004

    • Author(s)
      Taoka Y, Okajima K, Uchiba M
    • Journal Title

      J Neurotrauma 21

      Pages: 1818-1830

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacvclin in rats.2004

    • Author(s)
      Okajima K, Harada N, Uchiba M, Mori M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 287

      Pages: 1116-1123

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-12004

    • Author(s)
      Harada N, Okajima K, Uchiba M, Kushimoto S, Isobe H.
    • Journal Title

      Thromb Haemost 92

      Pages: 550-558

    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Antithrombin reduces compression-induced spinal cord injury in rats.2004

    • Author(s)
      Taoka Y, Okajima K, Uchiba M
    • Journal Title

      J Neurotrauma 21

      Pages: 1818-1830

    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats.2004

    • Author(s)
      Okajima K, Harada N, Uchiba M, Mori M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 287

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-12004

    • Author(s)
      Harada N, Okajima K, Uchiba M, Kushimoto S, Isobe H
    • Journal Title

      Thromb Haemost 92

      Pages: 550-558

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Inhibition of the endothelial cell activation by antithrombin in vitro.2004

    • Author(s)
      Uchiba M, Okajima K, Kaun C, Wojta J, Binder BR
    • Journal Title

      Thromb Haemost 92

      Pages: 1420-1427

    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Neutrophil elastase contributes to the development of ischemia-reperfiasion-induced liver injury by decreasing endothelial production of prostacyclin in rats.2004

    • Author(s)
      Okajima K, Harada N, Uchiba M, Mori M.
    • Journal Title

      Am J Physiol Gastroinlest Liver Physiol. 287

      Pages: 1116-1123

    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Inhibition of the endothelial cell activation by antithrombin in vitro.2004

    • Author(s)
      Uchiba M, Okajima K, Kaun C, Wojta J, Binder BR.
    • Journal Title

      Thromb Haemost. 92

      Pages: 1420-1427

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Antithrombin reduces the ischemia/reperfusion-induced spinal cord injury in rats by attenuating inflammatory responses.2004

    • Author(s)
      Hirose K, Okajima K, Uchiba M, Nakano KY, Utoh J, Kitamura N.
    • Journal Title

      Thromb Haemost. 91

      Pages: 162-170

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Antithrombin reduces compression-induced spinal cord injury in rats.2004

    • Author(s)
      Taoka Y, Okajima K, Uchiba M.
    • Journal Title

      J Neurotrauma. 21

      Pages: 1818-1830

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Inhibition of the endothelial cell activation by antithrombin in vitro.2004

    • Author(s)
      Uchiba M, Okajima K, Kaun C, Wojta J, Binder BR.
    • Journal Title

      Thromb Haemost. 92

      Pages: 1420-7

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-12004

    • Author(s)
      Harada N, Okajima K, Uchiba M, Kushimoto S, Isobe H
    • Journal Title

      Thromb Haemost 92

      Pages: 550-558

    • Data Source
      KAKENHI-PROJECT-16591810
  • [Journal Article] Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro.2003

    • Author(s)
      Uchiba M, Okajima K, Kaun C, Binder BR, Wojta J.
    • Journal Title

      Crit Care Med. 31

      Pages: 1147-1153

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Prostaglandin e(1) reduces compression trauma-induced spinal cord injury in rats mainly by inhibiting neutrophil activation.2003

    • Author(s)
      Naruo S, Okajima K, Taoka Y, Uchiba M, Nakamura T, Okabe H, Takagi K.
    • Journal Title

      J Neurotrauma. 20

      Pages: 221-228

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Contribution of capsaicin-sensitive sensory neurons to stress-induced increases in gastric tissue levels of prostaglandins in rats.2003

    • Author(s)
      Harada N, Okajima K, Uchiba M, Katsuragi T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 285

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production.2003

    • Author(s)
      Mizutani A, Okajima K, Uchiba M, Isobe H, Harada N, Mizutani S, Noguchi T.
    • Journal Title

      Blood 101

      Pages: 3029-3036

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Gabexate Mesilate, a Synthetic Protease Inhibitor, Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Production by Inhibiting Activation of Both Nuclear Factor-kappaB and Activator Protein-1 in Human Monocytes.2003

    • Author(s)
      Yuksel M, Okajima K, Uchiba M, Okabe H.
    • Journal Title

      J Pharmacol Exp Ther. 305

      Pages: 298-305

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • [Journal Article] Microthrombus formation enhances tumor necrosis factor-alpha production in the development of ischemia/reperfusion-induced liver injury in rats.2003

    • Author(s)
      Okajima K, Harada N, Uchiba M.
    • Journal Title

      J Thromb Haemost. 1

      Pages: 1316-1317

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591919
  • 1.  OKAJIMA Kenji (60152295)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 45 results
  • 2.  登尾 一平 (00832007)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  高橋 一広 (80794528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  上妻 行則 (90550145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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