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Kikuchi Akihiro  菊地 晶裕

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… Alternative Names

菊地 晶裕  キクチ アキヒロ

KIKUCHI Akihiro  菊地 晶裕

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Researcher Number 90321752
Affiliation (Current) 2025: 宇都宮短期大学, 食物栄養学科, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2023: 生理学研究所, 生体機能調節研究領域, 特任助教
2018 – 2019: 生理学研究所, 生体機能調節研究領域, 特任助教
2014 – 2017: 金沢大学, 医学系, 博士研究員
2012: 独立行政法人理化学研究所, 城生体金属科学研究室, 客員研究員
2011 – 2012: 金沢大学, 医学系, 博士研究員 … More
2004 – 2006: 独立行政法人理化学研究所, 城生体金属科学研究室, 研究員
2003: 独立行政法人理化学研究所, 生体物理化学研究室, 研究員
2002: 理化学研究所, 生体物理化学研究室, 研究員
2001: 理化学研究所, 生体物理化学研究室, 基礎科学特別研究員 Less
Review Section/Research Field
Principal Investigator
Metabolomics / Basic Section 54040:Metabolism and endocrinology-related / General physiology / Functional biochemistry / Applied biochemistry / Inorganic chemistry
Except Principal Investigator
Chemistry related to living body
Keywords
Principal Investigator
タンパク質結晶構造解析 / 情報伝達タンパク質 / ETR1 / エチレン / セレノプロテイン / 糖尿病 / LDL受容体ファミリー / 結晶構造解析 / ヘパトカイン / 情報伝達たんぱく質 … More / シングルセル遺伝子発現解析 / アディポカイン / 1型糖尿病 / シングルセル解析 / シングル核RNA-seq解析 / 臓器間ネットワーク / IL-6 / マイオカイン / 1型糖尿病 / 相互作用解析 / タンパク質間相互作用解析 / 2型糖尿病 / タンパク質間相互作用 / 2型糖尿病 / タンパク質構造モデル / タンパク質相互作用解析 / ホモロジーモデリング / セレノプロテインP / X線吸収スペクトル / X線吸収スペクトル / トランスポーター / ミネラル / 活性酸素 / 2成分情報伝達系 / 植物ホルモン / 2成分系情報伝達系 / 形質転換シロイヌナズナ / 膜たんぱく質 / bioXAS / 膜タンパク質 / 銅錯体 / DV-Xα / XAFS … More
Except Principal Investigator
X線結晶構造解析 / チトクロム酸化酵素 / 一酸化窒素還元酵素 / 分子進化 / オゾン層破壊 / 温室効果ガス / 亜酸化窒素 / 脱窒 / 呼吸酵素 / 一酸化窒素 Less
  • Research Projects

    (8 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (12 People)
  •  Study of myokine-mediated inter-organ cross-talk in type 1 diabetesPrincipal Investigator

    • Principal Investigator
      Kikuchi Akihiro
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      National Institute for Physiological Sciences
  •  Structural analysis of the interaction between selenoprotein P and its receptorsPrincipal Investigator

    • Principal Investigator
      Kikuchi Akihiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      National Institute for Physiological Sciences
      Kanazawa University
  •  Structural analysis of selenoprotein P as a diabetes-associated hepatokinePrincipal Investigator

    • Principal Investigator
      Kikuchi Akihiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Kanazawa University
  •  Molecular mechanism of mineral transport related to cellular reactive oxygen species levelPrincipal Investigator

    • Principal Investigator
      KIKUCHI Akihiro
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General physiology
    • Research Institution
      Kanazawa University
  •  Molecular Evolution of Respiratory Enzymes; Functional Conversion from NO Reduction to O2 Reduction

    • Principal Investigator
      SHIRO Yoshitsugu
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Chemistry related to living body
    • Research Institution
      The Institute of Physical and Chemical Research
  •  エチレンセンサーたんぱく質ETR1における情報伝達機構の解明Principal Investigator

    • Principal Investigator
      菊地 晶裕
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      The Institute of Physical and Chemical Research
  •  エチレンセンサーたんぱく質ETR1のシロイヌナズナによる発現系構築と構造解析Principal Investigator

    • Principal Investigator
      菊地 晶裕
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied biochemistry
    • Research Institution
      The Institute of Physical and Chemical Research
  •  XAFS法によるエチレンセンサーたんぱく質ETR1のセンサー部位の構造解析Principal Investigator

    • Principal Investigator
      菊地 晶裕
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Inorganic chemistry
    • Research Institution
      The Institute of Physical and Chemical Research

All 2023 2022 2019 2018 2017 2016 2012 2010 2009 2005 Other

All Journal Article Presentation Book

  • [Book] 肝臓の糖・エネルギー代謝 (「Diabetes Frontier」 Vol.28, No.6の特集「糖尿病と肝臓」を分担)2017

    • Author(s)
      菊地 晶裕、 篁 俊成
    • Total Pages
      7
    • Publisher
      メディカルレビュー社
    • ISBN
      9784779220203
    • Data Source
      KAKENHI-PROJECT-17K09822
  • [Book] セレノプロテインPの新たな機能と受容体 (「内分泌・糖尿病・代謝内科」 Vol.44, No 5の話題を担当)2017

    • Author(s)
      菊地 晶裕、 篁 俊成
    • Total Pages
      8
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-17K09822
  • [Book] 実験医学増刊「「解明」から「制御」へ 肥満症のメディカルサイエンス」(1章5節「過栄養に応答した肝臓の代謝リモデリング」を分担)2016

    • Author(s)
      菊地 晶裕、篁 俊成
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-26461328
  • [Book] 金属錯体の機器分析(下)2012

    • Author(s)
      大塩寛紀(編著)、菊地晶裕(共著)
    • Total Pages
      398
    • Publisher
      三共出版
    • Data Source
      KAKENHI-PROJECT-23790264
  • [Book] 金属錯体の機器分析(下)2012

    • Author(s)
      大塩 寛紀(編著)、菊地 晶裕(共著)
    • Publisher
      三共出版
    • Data Source
      KAKENHI-PROJECT-23790264
  • [Journal Article] p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes2019

    • Author(s)
      Igawa Hirobumi、Kikuchi Akihiro、Misu Hirofumi、Ishii Kiyo-aki、Kaneko Shuichi、Takamura Toshinari
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 10 Issue: 1 Pages: 32-42

    • DOI

      10.1111/jdi.12866

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09822, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-18K19560, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-17H04199
  • [Journal Article] Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans2019

    • Author(s)
      Mohri K, Misu H, Takayama H, Ishii KA, Kikuchi A, Lan F, Enyama Y, Takeshita Y, Saito Y, Kaneko S,Takamura T.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 3 Pages: 373-378

    • DOI

      10.1248/bpb.b18-00549

    • NAID

      130007607371

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-03-01
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-18K19560, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-19K08975, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-17K09822, KAKENHI-PROJECT-17H03821
  • [Journal Article] Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia2019

    • Author(s)
      Hosokawa K, Mizumaki H, Elbadry M, Saito C, Espinoza JL, An DTT, Katagiri T, Harashima A, Kikuchi A, Kanai A, Matsui H, Inaba T, Taniwaki M, Yamamoto Y, Nakao S
    • Journal Title

      Leukemia

      Volume: 33 Issue: 11 Pages: 2732-2766

    • DOI

      10.1038/s41375-019-0510-0

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06889, KAKENHI-PROJECT-18K07551, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17823, KAKENHI-PROJECT-19H03686, KAKENHI-PROJECT-17K09007, KAKENHI-PROJECT-17K09822
  • [Journal Article] The clinical course and potential underlying mechanisms of everolimus-induced hyperglycemia2019

    • Author(s)
      Tanimura Jun、Nakagawa Hiromi、Tanaka Takeo、Kikuchi Akihiro、Osada Sachie、Tanaka Yoshiaki、Tokuyama Kumpei、Takamura Toshinari
    • Journal Title

      Endocr J

      Volume: 66 Issue: 7 Pages: 615-620

    • DOI

      10.1507/endocrj.EJ18-0542

    • NAID

      130007684324

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09822
  • [Journal Article] Inhibin betaE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples2018

    • Author(s)
      M. Sugiyama, A. Kikuchi, H. Misu, H. Igawa, M. Ashihara, Y. Kushima, K. Honda, Y. Suzuki, Y. Kawabe, S. Kaneko and T. Takamura
    • Journal Title

      PLoS One

      Volume: 13 Issue: 3 Pages: e0194798-e0194798

    • DOI

      10.1371/journal.pone.0194798

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-17K09822, KAKENHI-PROJECT-17H04199, KAKENHI-ORGANIZER-17H06391
  • [Journal Article] Where does liver fat go? A possible molecular link between fatty liver and diabetes2017

    • Author(s)
      Akihiro Kikuchi, Toshinari Takamura
    • Journal Title

      J. Diabetes Invest

      Volume: 8 Issue: 2 Pages: 152-154

    • DOI

      10.1111/jdi.12573

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461328, KAKENHI-PROJECT-26461329
  • [Journal Article] Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle.2017

    • Author(s)
      H Misu, H Takayama, Y Saito, Y Mita, A Kikuchi, K Ishii, K Chikamoto, T Kanamori, N Tajima, F Lan, Y Takeshita, M Honda, M Tanaka, S Kato, N Matsuyama, Y Yoshioka, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, S Kaneko, T Takamura.
    • Journal Title

      Nature Med

      Volume: 23 Issue: 4 Pages: 508-516

    • DOI

      10.1038/nm.4295

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26461328, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K09739, KAKENHI-PROJECT-16K09740, KAKENHI-PROJECT-25292078, KAKENHI-PROJECT-17H04199
  • [Journal Article] Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice.2016

    • Author(s)
      K Chikamoto, H Misu, H Takayama, A Kikuchi, KA Ishii, F Lan, N Takata, N Tajima-Shirasaki, Y Takeshita, H Tsugane, S Kaneko, S Matsugo, T Takamura.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 478 Issue: 3 Pages: 1310-1316

    • DOI

      10.1016/j.bbrc.2016.08.117

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-26461328, KAKENHI-PROJECT-26461329, KAKENHI-PROJECT-26461377, KAKENHI-PROJECT-16K09740
  • [Journal Article] Creation of a Binuclear Purple Copper Site within a de Novo Coiled-Coil Protein2012

    • Author(s)
      D. Shiga, Y. Funahashi, H. Masuda, A. Kikuchi, M. Noda, S. Uchiyama, K. Fukui, K. Kanaori, K. Tajima, Y. Takano, H. Nakamura, M. Kamei, T. Tanaka
    • Journal Title

      Biochemistry

      Volume: 51 Issue: 40 Pages: 7901-7907

    • DOI

      10.1021/bi3007884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22550060, KAKENHI-PROJECT-22550150, KAKENHI-PROJECT-23790264, KAKENHI-PUBLICLY-23104506
  • [Journal Article] Unique Properties and reactivity of High-Valent Manganese-Oxo versus Manganese-Hydroxo in the Salen Platform2010

    • Author(s)
      T. Kurahashi, A. Kikuchi, Y. Shiro, M. Hada, H. Fujii
    • Journal Title

      Inorg. Chem

      Volume: 49 Pages: 6664-6672

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21245041
  • [Journal Article] Unique Properties and reactivity of High-Valent Manganese-Oxo versus Manganese-Hydroxo in the Salen Platform2010

    • Author(s)
      T.Kurahashi, A.Kikuchi, Y.Shiro, M.Hada, H.Fujii
    • Journal Title

      Inorg.Chem.

      Volume: 49 Pages: 6664-6672

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21245041
  • [Journal Article] Excited States of Fluorescent Proteins, mKO and DsRed: Chromophore-protein Electrostatic Interaction Behind the Color Variations2010

    • Author(s)
      J. Hasegawa, Y. Ise, K. Fujimoto, A. Kikuchi, E. Fukumura, A. Miyawaki, Y. Shiro
    • Journal Title

      J. Phys. Chem

      Volume: B 114 Pages: 2971-2979

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21245041
  • [Journal Article] Crystal Structure of a New Cyan Fluorescent Protein and Its Blue-shifted Variants2009

    • Author(s)
      A. Kikuchi, E. Fukumura, S. Karasawa, Y. Shiro, A. Miyawaki
    • Journal Title

      Biochemistry

      Volume: 48 Pages: 5276-5283

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21245041
  • [Journal Article] Crystal Structure of a New Cyan Fluorescent Protein and Its Hue-shifted Variants2009

    • Author(s)
      A.Kikuchi, E.Fukumura, S.Karasawa, Y.Shiro, A.Miyawaki
    • Journal Title

      Biochemistry

      Volume: 48 Pages: 5276-5283

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21245041
  • [Journal Article] Excited States of Fluorescent Proteins, mKO and DsRed : Chromophore-protein Electrostatic Interaction Behind the Color Variations2009

    • Author(s)
      J.Hasegawa, Y.Ise, K.Fujimoto, A.Kikuchi, E.Fukumura, A.Miyawaki, Y.Shiro
    • Journal Title

      J.Phys.Chem.B

      Volume: 114 Pages: 2971-2979

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21245041
  • [Journal Article] Tolerance of the Rieske-type [2Fe-2S] cluster in recombinant BphA3 from Pseudomonas sp, KKS 102 to histidine-ligand mutations2005

    • Author(s)
      Kimura, S., Kikuchi, A., Senda, T., Shiro.Y., Fukuda, M.
    • Journal Title

      Biochem.J. (印刷中)

    • Data Source
      KAKENHI-PROJECT-15780080
  • [Presentation] 視床下部室傍核CRHニューロンのシングル核RNA-seq解析2023

    • Author(s)
      菊地 晶裕、郷 康広、近藤 邦生、箕越 靖彦
    • Organizer
      食欲・食嗜好を形成する感覚・内分泌・神経基盤研究会2023
    • Data Source
      KAKENHI-PROJECT-21K08590
  • [Presentation] 視床下部室傍核CRHニューロンのシングル核RNA-seq解析2022

    • Author(s)
      菊地 晶裕、 郷 康広、 近藤 邦生、 箕越 靖彦
    • Organizer
      第48回日本神経内分泌学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K08590
  • [Presentation] 視床下部室傍核CRHニューロンのシングル核RNA解析2022

    • Author(s)
      菊地 晶裕、郷 康広、近藤 邦生、箕越 靖彦
    • Organizer
      第25回アディポサイエンス・シンポジウム
    • Data Source
      KAKENHI-PROJECT-21K08590
  • [Presentation] CRHニューロンのシングル核解析により明らかとなった新規クラスターの発見2022

    • Author(s)
      菊地 晶裕、郷 康広、近藤 邦生、箕越 靖彦
    • Organizer
      第42回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-21K08590
  • [Presentation] 肝脂肪化を感知するヘパトカインLECT2のマウスにおける体内動態2019

    • Author(s)
      菊地 晶裕、 高山 浩昭、 柴 和弘、 御簾 博文、 箕越 靖彦、 篁 俊成
    • Organizer
      第40回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-17K09822
  • [Presentation] 肥満関連ヘパトカインLECT2のマウスにおける血中半減期および体内動態2019

    • Author(s)
      菊地 晶裕、高山 浩昭、柴 和弘、御簾 博文、篁 俊成
    • Organizer
      第62回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-17K09822
  • [Presentation] 病態形成ヘパトカインLECT2のマウスにおける体内動態2018

    • Author(s)
      菊地 晶裕、 高山 浩昭、 津金 寛彦、 Swe Mar Oo、 御簾 博文、 柴 和弘、 篁 俊成
    • Organizer
      学際科学実験センターシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K09822
  • [Presentation] 新規な肥満関連ヘパトカインinhibin βEの同定と機能解析2018

    • Author(s)
      菊地 晶裕、 御簾 博文、 井川 寛章、 篁 俊成
    • Organizer
      第39回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-17K09822
  • [Presentation] インスリン受容体基質(IRS-1)の栄養依存的タンパク質発現変動における選択的オートファジー受容体p62介在性オートファジーの役割2018

    • Author(s)
      井川 寛章、 菊地 晶裕、 御簾 博文、石井 清明、 金子 周一、 篁 俊成
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-17K09822
  • [Presentation] Regulation of Insulin Signaling Molecules by Selective Autophagy in Mice with Proteasome Dysfunction and Starvation2017

    • Author(s)
      Akihiro Kikuchi, Hirobumi Igawa, Yumiko Tahira, Toshinari Takamura
    • Organizer
      2017 Keystone Symposia Conference
    • Place of Presentation
      Keystone, Colorado, USA
    • Year and Date
      2017-01-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461328
  • [Presentation] 立体構造と理論計算に基づく蛍光タンパク質の設計2010

    • Author(s)
      菊地晶裕、長谷川淳也、唐澤智司、城宜嗣
    • Organizer
      第10回日本蛋白質化学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-18
    • Data Source
      KAKENHI-PROJECT-21245041
  • [Presentation] μSR法による鉄ポルフィリンの微視的観測-μSR法によるヘムタンパク質の解明を目指して2009

    • Author(s)
      菊地晶裕、渡邊功雄、城宜嗣
    • Organizer
      第59回錯体化学討論会
    • Place of Presentation
      長崎
    • Year and Date
      2009-09-26
    • Data Source
      KAKENHI-PROJECT-21245041
  • [Presentation] 糖尿病病態形成ヘパトカイン・セレノプロテインPの結晶化

    • Author(s)
      菊地 晶裕
    • Organizer
      第7回北陸合同バイオシンポジウム
    • Place of Presentation
      八尾ゆめの森(富山県富山市)
    • Year and Date
      2014-11-28 – 2014-11-29
    • Data Source
      KAKENHI-PROJECT-26461328
  • 1.  SHIRO Yoshitsugu (70183051)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 2.  SUGIMOTO Hiroshi (90344043)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  NAGANO Shingo (60286440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  TOSHA Takehiro (00548993)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  TAKAMURA Toshinari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 6.  HARASHIMA Ai
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  舩橋 靖博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  御簾 博文
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 9.  竹下 有美枝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 10.  金子 周一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  山本 靖彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  本多 政夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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