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HORIUCHI Masataka  堀内 正隆

ORCIDConnect your ORCID iD *help
… Alternative Names

堀内 正隆  ホリウチ マサタカ

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Researcher Number 90322825
Other IDs
External Links
Affiliation (Current) 2021: 北海道医療大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2020: 北海道医療大学, 薬学部, 准教授
2017 – 2018: 北海道医療大学, 薬学部, 講師
2013 – 2014: 北海道医療大学, 薬学部, 講師
2012: 北海道大学, 薬学研究科(研究院), 助教
2007 – 2011: Hokkaido University, 大学院・薬学研究院, 助教 … More
2006: 北海道大学, 大学院・薬学研究院, 助手
2006: 北海道大学, 大学院薬学研究院, 助手
2001 – 2005: 北海道大学, 大学院・薬学研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Structural biochemistry / Structural biochemistry / Biological Sciences / Virology / Biofunction/Bioprocess / Bio-related chemistry
Except Principal Investigator
Dental engineering/Regenerative dentistry / Biological pharmacy / Prosthetic dentistry / Structural biochemistry / Basic Section 43020:Structural biochemistry-related / Basic Section 57050:Prosthodontics-related
Keywords
Principal Investigator
蛋白質 / シグナル伝達 / リン酸化 / 構造生物学 / ウイルス / 分子認識 / 感染症 / バイオテクノロジー / DNA結合蛋白質 / 核磁気共鳴 … More / 細胞増殖抑制因子 / BTG / Tobファミリー / X線結晶構造解析 / 蛋白質間相互作用 / 生殖細胞分化 / RNA代謝 / 翻訳調節 / 放射光 / X線結晶解析 / 円偏光二色性スペクトル / 自然免疫 / インターフェロン / ウィルス / ナノバイオ / タンパク質 / バイオリアクター / 生物・生体工学 / ナノ材料 / タンパク質工学 / アフィニティークロマトグラフィー / 固定化酵素 / カードラン / GRP-tag / 融合タンパク質 / アゾ色素 / プロテインライゲーション / 酵素反応 / 分子機械 / 環境技術 … More
Except Principal Investigator
オッセオインテグレーション / 好中球活性酸素発生系 / SH3ドメイン / マイクロアレイ / チタンインプラント / インプラント周囲炎 / チタン / 自然免疫 / NADPH酸化酵素 / PXドメイン / インターフェロン産生系 / TLR / TIR / IRF-3 / リン酸化 / Βgrp / β1-3グルカン / インターフェロン / 活性制御 / RLR / βGRP / TIRドメイン / TICAM1 / TRIF / TRAM / 細胞質因子 / p40 / ファゴソーム / PI(3)P / RIGI / CARDドメイン / Real time PCR / 蛋白質間相互作用 / 活性化機構 / 自己阻害 / p47タンデムSH3 / PRRペプチド / 新規NMR技術 / phagocyte oxidation system / protein-protein interaction / SH3 domain / activation mechanism / auto inhibition / p47 tandem SH3 domains / PRR peptide / 歯科 / 生体材料 / 遺伝子 / 蛋白質 / 線維芽細胞増殖因子 / アプタマー / 構造解析 / 物理化学的解析 / 論理的設計 Less
  • Research Projects

    (13 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (19 People)
  •  繊維芽細胞増殖因子FGF5と受容体の相互作用およびアプタマーの阻害機序の解明Ongoing

    • Principal Investigator
      坂本 泰一
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Chiba Institute of Technology
  •  遺伝子情報に基づいたインプラント周囲炎の画期的治療法の開発Ongoing

    • Principal Investigator
      堀内 留美
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57050:Prosthodontics-related
    • Research Institution
      Hokkaido University
  •  Low-cost degradation of azo dyes using the artifitial multi-domain enzymes immobilized on the sheet.Principal InvestigatorOngoing

    • Principal Investigator
      堀内 正隆
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bio-related chemistry
    • Research Institution
      Health Sciences University of Hokkaido
  •  オッセオインテグレ―ション関連因子を用いた新規インプラント周囲骨再生治療の開発Ongoing

    • Principal Investigator
      堀内 留美
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dental engineering/Regenerative dentistry
    • Research Institution
      Hokkaido University
  •  Studies of the low-cost immobilization system for recombinant proteins using beta-GRP and curdlan.Principal Investigator

    • Principal Investigator
      HORIUCHI Masataka
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biofunction/Bioprocess
    • Research Institution
      Health Sciences University of Hokkaido
      Hokkaido University
  •  Investigation of the inhibitory factors in osseointegration for the clinical application.

    • Principal Investigator
      HORIUCHI Rumi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Prosthetic dentistry
    • Research Institution
      Hokkaido University
  •  Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.

    • Principal Investigator
      HORIUCHI Rumi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Dental engineering/Regenerative dentistry
    • Research Institution
      Hokkaido University
  •  蛍光標識RIG-I蛋白質を用いたウイルスRNAセンサーの創製Principal Investigator

    • Principal Investigator
      堀内 正隆
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Virology
    • Research Institution
      Hokkaido University
  •  Structural Biology of Innate Immunity

    • Principal Investigator
      INAGAKI Fuyuhiko
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokkaido University
  •  インターフェロン誘導因子IRF-3の関与するシグナル伝達機構の構造生物学的研究Principal Investigator

    • Principal Investigator
      堀内 正隆
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  立体構造情報に基づくBTG/Tobファミリー蛋白質の細胞増殖抑制機構の解明Principal Investigator

    • Principal Investigator
      堀内 正隆
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Hokkaido University
  •  Structural Biology of Phagocyte oxidation

    • Principal Investigator
      INAGAKI Fuyuhiko
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Structural biochemistry
    • Research Institution
      Hokkaido University
  •  化学的組継ぎ法により作成したリン酸化Max蛋白質の機能と構造に関する研究Principal Investigator

    • Principal Investigator
      堀内 正隆
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Hokkaido University

All 2019 2017 2014 2013 2012 2011 2009 Other

All Journal Article Presentation

  • [Journal Article] Identification of a new autoinhibitory domain of interferon-beta promoter stimulator-1 (IPS-1) for the tight regulation of oligomerization-driven signal activation.2019

    • Author(s)
      Takahasi Kiyohiro、Onomoto Koji、Horiuchi Masataka、Kato Hiroki、Fujita Takashi、Yoneyama Mitsutoshi
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 517 Pages: 662-669

    • DOI

      10.1016/j.bbrc.2019.07.099

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K05936, KAKENHI-PROJECT-19K07589, KAKENHI-PROJECT-18H02660
  • [Journal Article] The N-terminal domain of TIR domain-containing adaptor molecule-1, TICAM-1.2014

    • Author(s)
      Kumeta H, Sakakibara H, Enokizono Y, Ogura K, Horiuchi M, Matsumoto M, Seya T, Inagaki F.
    • Journal Title

      J. Biomolec. NMR

      Volume: 58(3) Pages: 227-230

    • DOI

      10.1007/s10858-014-9819-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22121008, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24560954
  • [Journal Article] Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.2013

    • Author(s)
      Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 110(49) Pages: 19908-13

    • DOI

      10.1073/pnas.1222811110

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22114008, KAKENHI-PLANNED-22121008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24560954, KAKENHI-PROJECT-24659214
  • [Journal Article] SuperNova, a monomeric photosensitizing fluorescent protein for chromophore-assisted light inactivation.2013

    • Author(s)
      K. Takemoto (1), T. Matsuda (2)., 他12名
    • Journal Title

      Scientific Reports

      Volume: 3巻 Pages: 2629-2629

    • DOI

      10.1038/srep02629

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21687007, KAKENHI-PLANNED-23115003, KAKENHI-PROJECT-24560954, KAKENHI-PROJECT-25650052
  • [Journal Article] A low-cost affinity purification system using β-1,3-glucan recognition protein and curdlan beads2012

    • Author(s)
      Horiuchi, M., Takahasi, K., Kobashigawa, Y., Ochiai, M. and Inagaki, F.
    • Journal Title

      Protein Eng Des Sel

      Volume: 25 Pages: 405-413

    • DOI

      10.1093/protein/gzs028

    • NAID

      120004405566

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23580069, KAKENHI-PROJECT-24560954, KAKENHI-PLANNED-22121008
  • [Journal Article] Solution structure of the silkworm βGRP/GNBP3 N-terminal domain reveals the mechanism for β-1, 3-glucan-specific recognition.2009

    • Author(s)
      Takahasi K., Ochiai M., Horiuchi M., Kumeta H., Ogura K., Ashida M., Inagaki F.
    • Journal Title

      Proc Natl Acad Sci U S A 106

      Pages: 11679-11684

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17109002
  • [Journal Article] Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors.

    • Author(s)
      Takahasi K., Kumeta H., Tsuduki N., Narita R., Shigemoto T., Hirai R., Yoneyama M., Horiuchi M., Ogura K., Fujita T., Inagaki F.
    • Journal Title

      J Biol Chem

      Pages: 17465-17474

    • NAID

      120001415118

    • Data Source
      KAKENHI-PROJECT-17109002
  • [Presentation] SELEX実験におけるGRPタグの利用2019

    • Author(s)
      大久保広稀,天野亮,堀内正隆,坂本泰一
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K05936
  • [Presentation] Selection and characterization of aptamers against fibroblast growth factor (FGF) 52019

    • Author(s)
      Minami Saso, Ryo Amano, Masato Namekata, Masataka Horiuchi, Takuya Yanagisawa, Kakeru Nishimoto, Yoichiro Tanaka, Farhana Ishrat Ghani, Masakuni Yamamoto, Taiichi Sakamoto
    • Organizer
      The 46th International Symposium on Nucleic Acids Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K05936
  • [Presentation] Real-time NMR analysis of the continuous degradation process of azo dyes using azoreductase in cooperation with the NADPH regeneration system.2019

    • Author(s)
      Horiuchi, M., Nagata, T., Katahira, M., Kobashigawa, Y., Suzuki, Y., Ochiai, M.
    • Organizer
      The 9th International Symposium of Advanced Energy Science
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K05936
  • [Presentation] Continuous degradation of azo dyes using a hybrid azoreductase including NADPH regeneration system2019

    • Author(s)
      Masataka Horiuchi, Takashi Nagata, Masato Katahira, Yoshihiro Kobashigawa, Yasuhiko Suzuki, Masanori Ochiai
    • Organizer
      The 10th International Symposium of Advanced Energy Science ~Beyond the Decade of Zero Emission Energy~
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K05936
  • [Presentation] NADPH再生系を内包するハイブリッド型アゾレダクターゼの開発2019

    • Author(s)
      堀内正隆,永田崇,片平正人,小橋川敬博,鈴木定彦,落合正則
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K05936
  • [Presentation] 線維芽細胞増殖因子(FGF)5に対するアプタマーの取得と解析2019

    • Author(s)
      笹生みなみ,天野亮,行方昌人,堀内正隆,柳澤拓也,西本翔,田中陽一郎
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K05936
  • [Presentation] Development of the artificial multi-domain enzymes immobilized on the curdlan sheet at low cost.2017

    • Author(s)
      Horiuchi, M., Nagata, T., Katahira, M., Kobashigawa, Y., Suzuki, Y., Ochiai, M.
    • Organizer
      The 8th International Symposium of Advanced Energy Science
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K05936
  • [Presentation] チタンインプラントにおけるオッセオインテグレーション獲得に関する遺伝子の網羅的解析2012

    • Author(s)
      堀内留美
    • Organizer
      歯科チタン学会
    • Place of Presentation
      愛知学院大学歯学部(名古屋市)
    • Year and Date
      2012-02-19
    • Data Source
      KAKENHI-PROJECT-21592488
  • [Presentation] チタンインプラントにおけるオッセオインテグレーション獲得に関する遺伝子の網羅的解析2012

    • Author(s)
      堀内留美
    • Organizer
      歯科チタン学会
    • Place of Presentation
      愛知学院大学歯学部
    • Year and Date
      2012-02-19
    • Data Source
      KAKENHI-PROJECT-21592488
  • [Presentation] オッセオインテグレーション獲得および非獲得ラットモデルにおける遺伝子の網羅的解析2011

    • Author(s)
      堀内留美, 他
    • Organizer
      日本バイオマテリアル学会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2011-11-21
    • Data Source
      KAKENHI-PROJECT-21592488
  • [Presentation] Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.

    • Author(s)
      Horiuchi M, Horiuchi R, Ochiai M, Yokoyama A
    • Organizer
      The 28th Annual Symposium of the Protein Society
    • Place of Presentation
      Manchester Grand Hyatt (San Diego, USA)
    • Year and Date
      2014-07-27 – 2014-07-30
    • Data Source
      KAKENHI-PROJECT-24560954
  • [Presentation] Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.

    • Author(s)
      Masataka Horiuchi, Rumi Horiuchi, Masanori Ochiai, Atsuro Yokoyama
    • Organizer
      The 28th Annual Symposium of The Protein Society
    • Place of Presentation
      Manchester Grand Hyatt (San Diego,USA)
    • Year and Date
      2014-07-27 – 2014-07-30
    • Data Source
      KAKENHI-PROJECT-24592895
  • [Presentation] オッセオインテグレーション獲得に関わるタンパク質の昆虫細胞を用いた生産

    • Author(s)
      堀内留美,堀内正隆,横山敦郎
    • Organizer
      平成26年度 日本補綴歯科学会 東北北海道支部学術大会
    • Place of Presentation
      市民交流プラザ (郡山市)
    • Year and Date
      2014-10-25 – 2014-10-26
    • Data Source
      KAKENHI-PROJECT-24560954
  • [Presentation] オッセオインテグレーション獲得に関わるタンパク質の昆虫細胞を用いた生産

    • Author(s)
      堀内留美、堀内正隆、横山敦郎
    • Organizer
      平成26年度 日本補綴歯科学会 東北北海道支部学術大会
    • Place of Presentation
      市民交流プラザ(郡山市)
    • Year and Date
      2014-10-25 – 2014-10-26
    • Data Source
      KAKENHI-PROJECT-24592895
  • 1.  HORIUCHI Rumi (10374274)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 5 results
  • 2.  YOKOYAMA Atsuro (20210627)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 3.  INAGAKI Fuyuhiko (70011757)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 4.  OGURA Kenji (50270682)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  坂本 泰一 (40383369)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  NODA Nobuo (40396297)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  YAMAMOTO Satoru (10344524)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  高橋 清大 (90399965)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  落合 正則 (10241382)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  小椋 賢治 (14780469)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  永田 崇 (10415250)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 12.  杉山 成 (90615428)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  ONOMOTO Koji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  ARAI Yoshiyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  米山 光俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  瀬谷 司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 17.  松本 美佐子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 18.  松田 知己
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  永井 健治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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