HORIUCHI Masataka 堀内正隆

… Alternative Names

Researcher Number	90322825
Other IDs
External Links
Affiliation (Current)	2021: 北海道医療大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2020: 北海道医療大学, 薬学部, 准教授 2017 – 2018: 北海道医療大学, 薬学部, 講師 2013 – 2014: 北海道医療大学, 薬学部, 講師 2012: 北海道大学, 薬学研究科(研究院), 助教 2007 – 2011: Hokkaido University, 大学院・薬学研究院, 助教 … More
Review Section/Research Field	Principal Investigator Structural biochemistry / Structural biochemistry / Biological Sciences / Virology / Biofunction/Bioprocess / Bio-related chemistry Except Principal Investigator Dental engineering/Regenerative dentistry / Biological pharmacy / Prosthetic dentistry / Structural biochemistry / Basic Section 43020:Structural biochemistry-related / Basic Section 57050:Prosthodontics-related
Keywords	Principal Investigator 蛋白質 / シグナル伝達 / リン酸化 / 構造生物学 / ウイルス / 分子認識 / 感染症 / バイオテクノロジー / DNA結合蛋白質 / 核磁気共鳴 … More Except Principal Investigator オッセオインテグレーション / 好中球活性酸素発生系 / SH3ドメイン / マイクロアレイ / チタンインプラント / インプラント周囲炎 / チタン / 自然免疫 / NADPH酸化酵素 / PXドメイン / インターフェロン産生系 / TLR / TIR / IRF-3 / リン酸化 / Βgrp / β1-3グルカン / インターフェロン / 活性制御 / RLR / βGRP / TIRドメイン / TICAM1 / TRIF / TRAM / 細胞質因子 / p40 / ファゴソーム / PI(3)P / RIGI / CARDドメイン / Real time PCR / 蛋白質間相互作用 / 活性化機構 / 自己阻害 / p47タンデムSH3 / PRRペプチド / 新規NMR技術 / phagocyte oxidation system / protein-protein interaction / SH3 domain / activation mechanism / auto inhibition / p47 tandem SH3 domains / PRR peptide / 歯科 / 生体材料 / 遺伝子 / 蛋白質 / 線維芽細胞増殖因子 / アプタマー / 構造解析 / 物理化学的解析 / 論理的設計 Less

繊維芽細胞増殖因子FGF5と受容体の相互作用およびアプタマーの阻害機序の解明Ongoing
- Principal Investigator
  
  坂本泰一
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Chiba Institute of Technology
遺伝子情報に基づいたインプラント周囲炎の画期的治療法の開発Ongoing
- Principal Investigator
  
  堀内留美
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Hokkaido University
Low-cost degradation of azo dyes using the artifitial multi-domain enzymes immobilized on the sheet.Principal InvestigatorOngoing
- Principal Investigator
  
  堀内正隆
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Health Sciences University of Hokkaido
オッセオインテグレ―ション関連因子を用いた新規インプラント周囲骨再生治療の開発Ongoing
- Principal Investigator
  
  堀内留美
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Hokkaido University
Studies of the low-cost immobilization system for recombinant proteins using beta-GRP and curdlan.Principal Investigator
- Principal Investigator
  
  HORIUCHI Masataka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Health Sciences University of Hokkaido
  Hokkaido University
Investigation of the inhibitory factors in osseointegration for the clinical application.
- Principal Investigator
  
  HORIUCHI Rumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Hokkaido University
Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.
- Principal Investigator
  
  HORIUCHI Rumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Hokkaido University
蛍光標識RIG-I蛋白質を用いたウイルスRNAセンサーの創製Principal Investigator
- Principal Investigator
  
  堀内正隆
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Virology
- Research Institution
  Hokkaido University
Structural Biology of Innate Immunity
- Principal Investigator
  
  INAGAKI Fuyuhiko
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
インターフェロン誘導因子IRF-3の関与するシグナル伝達機構の構造生物学的研究Principal Investigator
- Principal Investigator
  
  堀内正隆
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
立体構造情報に基づくBTG/Tobファミリー蛋白質の細胞増殖抑制機構の解明Principal Investigator
- Principal Investigator
  
  堀内正隆
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hokkaido University
Structural Biology of Phagocyte oxidation
- Principal Investigator
  
  INAGAKI Fuyuhiko
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hokkaido University
化学的組継ぎ法により作成したリン酸化Max蛋白質の機能と構造に関する研究Principal Investigator
- Principal Investigator
  
  堀内正隆
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hokkaido University

All 2019 2017 2014 2013 2012 2011 2009 Other

All Journal Article Presentation

[Journal Article] Identification of a new autoinhibitory domain of interferon-beta promoter stimulator-1 (IPS-1) for the tight regulation of oligomerization-driven signal activation.2019
- Author(s)
  Takahasi Kiyohiro、Onomoto Koji、Horiuchi Masataka、Kato Hiroki、Fujita Takashi、Yoneyama Mitsutoshi
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 517 Pages: 662-669
- DOI
  10.1016/j.bbrc.2019.07.099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K05936, KAKENHI-PROJECT-19K07589, KAKENHI-PROJECT-18H02660
[Journal Article] The N-terminal domain of TIR domain-containing adaptor molecule-1, TICAM-1.2014
- Author(s)
  Kumeta H, Sakakibara H, Enokizono Y, Ogura K, Horiuchi M, Matsumoto M, Seya T, Inagaki F.
- Journal Title
  
  J. Biomolec. NMR
  
  Volume: 58（3） Pages: 227-230
- DOI
  10.1007/s10858-014-9819-1
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22121008, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24560954
[Journal Article] Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.2013
- Author(s)
  Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F.
- Journal Title
  
  Proc. Natl. Acad. Sci. U. S. A.
  
  Volume: 110(49) Pages: 19908-13
- DOI
  10.1073/pnas.1222811110
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PLANNED-22121008, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24560954, KAKENHI-PROJECT-24659214
[Journal Article] SuperNova, a monomeric photosensitizing fluorescent protein for chromophore-assisted light inactivation.2013
- Author(s)
  K. Takemoto (1), T. Matsuda (2)., 他12名
- Journal Title
  
  Scientific Reports
  
  Volume: 3巻 Pages: 2629-2629
- DOI
  10.1038/srep02629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21687007, KAKENHI-PLANNED-23115003, KAKENHI-PROJECT-24560954, KAKENHI-PROJECT-25650052
[Journal Article] A low-cost affinity purification system using β-1,3-glucan recognition protein and curdlan beads2012
- Author(s)
  Horiuchi, M., Takahasi, K., Kobashigawa, Y., Ochiai, M. and Inagaki, F.
- Journal Title
  
  Protein Eng Des Sel
  
  Volume: 25 Pages: 405-413
- DOI
  10.1093/protein/gzs028
- NAID
  120004405566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580069, KAKENHI-PROJECT-24560954, KAKENHI-PLANNED-22121008
[Journal Article] Solution structure of the silkworm βGRP/GNBP3 N-terminal domain reveals the mechanism for β-1, 3-glucan-specific recognition.2009
- Author(s)
  Takahasi K., Ochiai M., Horiuchi M., Kumeta H., Ogura K., Ashida M., Inagaki F.
- Journal Title
  
  Proc Natl Acad Sci U S A 106
  
  Pages: 11679-11684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109002
[Journal Article] Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors.
- Author(s)
  Takahasi K., Kumeta H., Tsuduki N., Narita R., Shigemoto T., Hirai R., Yoneyama M., Horiuchi M., Ogura K., Fujita T., Inagaki F.
- Journal Title
  
  J Biol Chem
  
  Pages: 17465-17474
- NAID
  120001415118
- Data Source
  KAKENHI-PROJECT-17109002
[Presentation] SELEX実験におけるGRPタグの利用2019
- Author(s)
  大久保広稀，天野亮，堀内正隆，坂本泰一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K05936
[Presentation] Selection and characterization of aptamers against fibroblast growth factor (FGF) 52019
- Author(s)
  Minami Saso, Ryo Amano, Masato Namekata, Masataka Horiuchi, Takuya Yanagisawa, Kakeru Nishimoto, Yoichiro Tanaka, Farhana Ishrat Ghani, Masakuni Yamamoto, Taiichi Sakamoto
- Organizer
  The 46th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05936
[Presentation] Real-time NMR analysis of the continuous degradation process of azo dyes using azoreductase in cooperation with the NADPH regeneration system.2019
- Author(s)
  Horiuchi, M., Nagata, T., Katahira, M., Kobashigawa, Y., Suzuki, Y., Ochiai, M.
- Organizer
  The 9th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05936
[Presentation] Continuous degradation of azo dyes using a hybrid azoreductase including NADPH regeneration system2019
- Author(s)
  Masataka Horiuchi, Takashi Nagata, Masato Katahira, Yoshihiro Kobashigawa, Yasuhiko Suzuki, Masanori Ochiai
- Organizer
  The 10th International Symposium of Advanced Energy Science ～Beyond the Decade of Zero Emission Energy～
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05936
[Presentation] NADPH再生系を内包するハイブリッド型アゾレダクターゼの開発2019
- Author(s)
  堀内正隆，永田崇，片平正人，小橋川敬博，鈴木定彦，落合正則
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K05936
[Presentation] 線維芽細胞増殖因子（FGF）5に対するアプタマーの取得と解析2019
- Author(s)
  笹生みなみ，天野亮，行方昌人，堀内正隆，柳澤拓也，西本翔，田中陽一郎
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K05936
[Presentation] Development of the artificial multi-domain enzymes immobilized on the curdlan sheet at low cost.2017
- Author(s)
  Horiuchi, M., Nagata, T., Katahira, M., Kobashigawa, Y., Suzuki, Y., Ochiai, M.
- Organizer
  The 8th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K05936
[Presentation] チタンインプラントにおけるオッセオインテグレーション獲得に関する遺伝子の網羅的解析2012
- Author(s)
  堀内留美
- Organizer
  歯科チタン学会
- Place of Presentation
  愛知学院大学歯学部(名古屋市)
- Year and Date
  2012-02-19
- Data Source
  KAKENHI-PROJECT-21592488
[Presentation] チタンインプラントにおけるオッセオインテグレーション獲得に関する遺伝子の網羅的解析2012
- Author(s)
  堀内留美
- Organizer
  歯科チタン学会
- Place of Presentation
  愛知学院大学歯学部
- Year and Date
  2012-02-19
- Data Source
  KAKENHI-PROJECT-21592488
[Presentation] オッセオインテグレーション獲得および非獲得ラットモデルにおける遺伝子の網羅的解析2011
- Author(s)
  堀内留美, 他
- Organizer
  日本バイオマテリアル学会
- Place of Presentation
  京都テルサ(京都府)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-21592488
[Presentation] Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.
- Author(s)
  Horiuchi M, Horiuchi R, Ochiai M, Yokoyama A
- Organizer
  The 28th Annual Symposium of the Protein Society
- Place of Presentation
  Manchester Grand Hyatt (San Diego, USA)
- Year and Date
  2014-07-27 – 2014-07-30
- Data Source
  KAKENHI-PROJECT-24560954
[Presentation] Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.
- Author(s)
  Masataka Horiuchi, Rumi Horiuchi, Masanori Ochiai, Atsuro Yokoyama
- Organizer
  The 28th Annual Symposium of The Protein Society
- Place of Presentation
  Manchester Grand Hyatt (San Diego,USA)
- Year and Date
  2014-07-27 – 2014-07-30
- Data Source
  KAKENHI-PROJECT-24592895
[Presentation] オッセオインテグレーション獲得に関わるタンパク質の昆虫細胞を用いた生産
- Author(s)
  堀内留美，堀内正隆，横山敦郎
- Organizer
  平成26年度日本補綴歯科学会東北北海道支部学術大会
- Place of Presentation
  市民交流プラザ (郡山市)
- Year and Date
  2014-10-25 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-24560954
[Presentation] オッセオインテグレーション獲得に関わるタンパク質の昆虫細胞を用いた生産
- Author(s)
  堀内留美、堀内正隆、横山敦郎
- Organizer
  平成26年度　日本補綴歯科学会　東北北海道支部学術大会
- Place of Presentation
  市民交流プラザ（郡山市）
- Year and Date
  2014-10-25 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-24592895

1. HORIUCHI Rumi (10374274)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. YOKOYAMA Atsuro (20210627)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. INAGAKI Fuyuhiko (70011757)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. OGURA Kenji (50270682)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 坂本泰一 (40383369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NODA Nobuo (40396297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAMOTO Satoru (10344524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高橋清大 (90399965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 落合正則 (10241382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 小椋賢治 (14780469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 永田崇 (10415250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. 杉山成 (90615428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. ONOMOTO Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. ARAI Yoshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 米山光俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 瀬谷司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 松本美佐子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 松田知己

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 永井健治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HORIUCHI Masataka 堀内 正隆

堀内 正隆 ホリウチ マサタカ

Research Projects

Research Products

Co-Researchers

繊維芽細胞増殖因子FGF5と受容体の相互作用およびアプタマーの阻害機序の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝子情報に基づいたインプラント周囲炎の画期的治療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Low-cost degradation of azo dyes using the artifitial multi-domain enzymes immobilized on the sheet.Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

オッセオインテグレ―ション関連因子を用いた新規インプラント周囲骨再生治療の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of the low-cost immobilization system for recombinant proteins using beta-GRP and curdlan.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the inhibitory factors in osseointegration for the clinical application.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the inhibitory factors for osseointegration in the early stage of the implantation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

蛍光標識RIG-I蛋白質を用いたウイルスRNAセンサーの創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural Biology of Innate Immunity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インターフェロン誘導因子IRF-3の関与するシグナル伝達機構の構造生物学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

立体構造情報に基づくBTG/Tobファミリー蛋白質の細胞増殖抑制機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural Biology of Phagocyte oxidation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

化学的組継ぎ法により作成したリン酸化Max蛋白質の機能と構造に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

HORIUCHI Masataka 堀内正隆

堀内正隆ホリウチマサタカ