Saisho Yoshifumi 税所芳史

Researcher Number	90327510
Other IDs	https://orcid.org/0000-0002-6071-4393
Affiliation (based on the past Project Information) *help	2021 – 2023: 慶應義塾大学, 医学部(信濃町), 講師(非常勤) 2016 – 2020: 慶應義塾大学, 医学部(信濃町), 講師 2015: 慶應義塾大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics
Keywords	Principal Investigator β細胞量 / 2型糖尿病 / 糖尿病 / 内分泌細胞 / グルカゴン / インスリン / 膵β細胞 / 組織学的検討 / α細胞量 / 日本人 … More / 肥満 / 予防 / 治療 / 膵組織 / ヒト / 免疫染色 / ヒト膵組織 / 膵α細胞量 / 膵β細胞量 / 低出生体重 / β細胞機能 / 耐糖能異常 / 組織学 / 膵内分泌細胞 Less

Development of novel strategy for treatment of diabetes based on exploring of human beta cell regulatorsPrincipal Investigator
- Principal Investigator
  
  YOSHIFUMI SAISHO
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Keio University
Regulatory mechanisms of human beta cell mass and its association with glucose tolerancePrincipal Investigator
- Principal Investigator
  
  SAISHO YOSHIFUMI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Keio University
Regulation of human beta cell massPrincipal Investigator
- Principal Investigator
  
  Saisho Yoshifumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Keio University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Dipeptidyl Peptidase-4 Inhibitors and Beta Cell Mass in Japanese Adults with Type 2 Diabetes2022
- Author(s)
  Sasaki Hironobu、Saisho Yoshifumi、Itoh Hiroshi
- Journal Title
  
  Endocrine Practice
  
  Volume: - Issue: 5 Pages: 563-564
- DOI
  10.1016/j.eprac.2022.02.001
- Data Source
  KAKENHI-PROJECT-21K08535
[Journal Article] Exenatide Once Weekly for Management of Type 2 Diabetes: A Review2022
- Author(s)
  Inaishi Jun、Saisho Yoshifumi
- Journal Title
  
  Clinical Pharmacology: Advances and Applications
  
  Volume: Volume 14 Pages: 19-26
- DOI
  10.2147/cpaa.s288846
- Data Source
  KAKENHI-PROJECT-21K08535
[Journal Article] Increased alpha cell to beta cell ratio in patients with pancreatic cancer2022
- Author(s)
  Tsuchiya Tami、Saisho Yoshifumi、Inaishi Jun、Sasaki Hironobu、Sato Midori、Nishikawa Masaru、Masugi Yohei、Yamada Taketo、Itoh Hiroshi
- Journal Title
  
  Endocr J
  
  Volume: 69 Issue: 12 Pages: 1407-1414
- DOI
  10.1507/endocrj.EJ22-0170
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08535, KAKENHI-PROJECT-21K18270, KAKENHI-PROJECT-22K19387, KAKENHI-PROJECT-20K17542
[Journal Article] Revisiting Regulators of Human β-cell Mass to Achieve β-cell?centric Approach Toward Type 2 Diabetes2021
- Author(s)
  Sasaki Hironobu、Saisho Yoshifumi、Inaishi Jun、Itoh Hiroshi
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 5 Issue: 10 Pages: 1-14
- DOI
  10.1210/jendso/bvab128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08535, KAKENHI-PROJECT-21K18270
[Journal Article] Reduced beta cell number rather than size is a major contributor to beta cell loss in type 2 diabetes2021
- Author(s)
  Sasaki Hironobu, Saisho Yoshifumi et al.
- Journal Title
  
  Diabetologia
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08488
[Journal Article] Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review2020
- Author(s)
  Inaishi Jun、Saisho Yoshifumi
- Journal Title
  
  Nutrients
  
  Volume: 12 Issue: 12 Pages: 3846-3846
- DOI
  10.3390/nu12123846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17542, KAKENHI-PROJECT-18K08488
[Journal Article] Associations of birthweight and history of childhood obesity with beta cell mass in Japanese adults2020
- Author(s)
  Sasaki H, Saisho Y, Inaishi J, Watanabe Y, Tsuchiya T, Makio M, Sato M, Kitago M, Yamada T, Itoh H
- Journal Title
  
  Diabetologia
  
  Volume: - Issue: 6 Pages: 1199-1210
- DOI
  10.1007/s00125-020-05127-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08488, KAKENHI-PROJECT-17H06270
[Journal Article] An emerging new concept for the management of type 2 diabetes with a paradigm shift from the glucose-centric to beta cell-centric concept of diabetes - an Asian perspective2020
- Author(s)
  Saisho Yoshifumi
- Journal Title
  
  Expert Opinion on Pharmacotherapy
  
  Volume: 21 Issue: 13 Pages: 1565-1578
- DOI
  10.1080/14656566.2020.1776262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08488
[Journal Article] Association of glucose tolerance status with pancreatic β‐ and α‐cell mass in community‐based autopsy samples of Japanese individuals: The Hisayama Study2020
- Author(s)
  Inaishi Jun、Saisho Yoshifumi、Hirakawa Yoichiro、Yoshida Daigo、Hata Jun、Mukai Naoko、Watanabe Yuusuke、Oda Yoshinao、Itoh Hiroshi、Ninomiya Toshiharu
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: - Issue: 5 Pages: 1197-1206
- DOI
  10.1111/jdi.13232
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08488, KAKENHI-PROJECT-17H06270, KAKENHI-PROJECT-18K16245
[Journal Article] Comprehensive study on human pancreatic beta-cell regulatory mechanism2019
- Author(s)
  Yoshifumi Saisho
- Journal Title
  
  Impact
  
  Volume: na Issue: 2 Pages: 38-40
- DOI
  10.21820/23987073.2019.2.38
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08488
[Journal Article] Changing the Concept of Type 2 Diabetes: Beta Cell Workload Hypothesis Revisited2019
- Author(s)
  Yoshifumi Saisho
- Journal Title
  
  Endocrine, metabolic & immune disorders drug targets
  
  Volume: 19 Issue: 2 Pages: 121-127
- DOI
  10.2174/1871530318666180821161825
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08488
[Journal Article] 膵α・β細胞容積2018
- Author(s)
  税所芳史
- Journal Title
  
  糖尿病
  
  Volume: 61 Pages: 48-50
- Data Source
  KAKENHI-PROJECT-15K09399
[Journal Article] How can we develop more effective strategies for type 2 diabetes mellitus prevention? A paradigm shift from a glucose-centric to a beta cell-centric concept of diabetes2018
- Author(s)
  Yoshifumi Saisho
- Journal Title
  
  European Medical Journal Diabetes
  
  Volume: 6 Pages: 46-52
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08488
[Journal Article] Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes2017
- Author(s)
  Inaishi Jun、Saisho Yoshifumi
- Journal Title
  
  J Clin Med
  
  Volume: 6 Issue: 12 Pages: 113-113
- DOI
  10.3390/jcm6120113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09399
[Journal Article] Pancreas fat and beta cell mass in humans with and without diabetes: An analysis in the Japanese population.2017
- Author(s)
  Murakami R, Saisho Y, Watanabe Y, Inaishi J, Tsuchiya T, Kou K, Sato S, Kitago M, Kitagawa Y, Yamada T, Itoh H.
- Journal Title
  
  The Journal of Clinical Endocrinology & Metabolism
  
  Volume: 102 Issue: 9 Pages: 3251-3260
- DOI
  10.1210/jc.2017-00828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-15K09399
[Journal Article] 2型糖尿病の発症メカニズム　膵β細胞workload仮説2017
- Author(s)
  税所芳史
- Journal Title
  
  臨床化学
  
  Volume: 46 Pages: 157-159
- Data Source
  KAKENHI-PROJECT-15K09399
[Journal Article] Effects of obesity and diabetes on alpha and beta cell mass in surgically resected human pancreas2016
- Author(s)
  Inaishi J, Saisho Y, Sato S, Kou K, Murakami R, Watanabe Y, Kitago M, Kitagawa Y, Yamada T, Itoh H
- Journal Title
  
  J Clin Endocrinol Metab
  
  Volume: 101 Issue: 7 Pages: 2874-82
- DOI
  10.1210/jc.2016-1374
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] 膵癌患者における膵α・β細胞量の変化についての検討2021
- Author(s)
  土屋多美, 税所芳史, 稲石淳, 渡辺雄祐, 佐々木裕伸, 牧尾将幹, 佐藤翠, 西川賢, 山田健人, 伊藤裕
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08535
[Presentation] 2型糖尿病におけるβ細胞量減少の主因は、β細胞サイズの低下ではなくβ細胞数の減少である2021
- Author(s)
  佐々木裕伸, 税所芳史, 稲石淳, 渡辺雄祐, 土屋多美, 牧尾将幹, 佐藤翠, 西川賢, 北郷実, 山田健人, 伊藤裕
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K08535
[Presentation] ヒト膵摘出症例における出生体重とα・β細胞量の関係についての検討2020
- Author(s)
  佐々木裕伸,税所芳史,稲石淳,渡辺雄祐,土屋多美,牧尾将幹,佐藤翠,北郷実,北川雄光,山田健人,伊藤裕
- Organizer
  日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-18K08488
[Presentation] 剖検例における耐糖能と膵β・α細胞量に関する検討　久山町研究2020
- Author(s)
  稲石淳, 税所芳史, 平川洋一郎, 吉田大悟, 秦淳, 向井直子, 渡辺雄祐, 小田義直, 伊藤裕, 二宮利治
- Organizer
  日本内科学会
- Data Source
  KAKENHI-PROJECT-18K08488
[Presentation] 久山町剖検例における糖代謝関連因子および遺伝的背景とα・β細胞量との関連2019
- Author(s)
  稲石淳, 税所芳史, 向井直子, 平川洋一郎, 吉田大悟, 秦淳, 渡辺雄祐, 小田義直, 伊藤裕, 二宮利治
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08488
[Presentation] Glucose tolerance status and beta and alpha cellmass in community-based autopsy samples of Japanese: the Hisayama study2019
- Author(s)
  Inaishi J, Saisho Y, Mukai N, Hirakawa Y, Yoshida D, Hata J, Watanabe Y, Oda Y, Itoh H, Ninomiya T
- Organizer
  55th Annual Meeting of the European Association for the Study of Diabetes
- Data Source
  KAKENHI-PROJECT-18K08488
[Presentation] 日本人での耐糖能とβ細胞機能および膵組織学的特徴との関連についての検討2019
- Author(s)
  稲石淳, 税所芳史, 向井直子, 平川洋一郎, 吉田大悟, 秦淳, 渡辺雄祐, 小田義直, 伊藤裕, 二宮利治
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08488
[Presentation] 肥満,糖尿病におけるヒト膵内分泌細胞量の変化についての検討2019
- Author(s)
  渡辺雄祐, 税所芳史, 稲石淳, 村上理恵, 土屋多美, 佐々木裕伸, 牧尾将幹, 北郷実, 北川雄光, 山田健人, 伊藤裕
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08488
[Presentation] Effects of obesity and diabetes on pancreatic endocrine cell mass and the relative change in humans2019
- Author(s)
  Watanabe Y, Saisho Y, Inaishi J, Murakami R, Tsuchiya T, Sasaki H, Makio M, Kitago M, Kitagawa Y, Yamada T, Itoh H
- Organizer
  55th Annual Meeting of the European Association for the Study of Diabetes
- Data Source
  KAKENHI-PROJECT-18K08488
[Presentation] 肥満、糖尿病におけるヒト膵内分泌細胞量の変化についての検討2018
- Author(s)
  渡辺雄祐, 税所芳史, 稲石淳, 村上理恵, 土屋多美, 佐々木裕伸, 北郷実, 北川雄光, 山田健人, 伊藤裕
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08488
[Presentation] 久山町剖検例における糖代謝関連因子とα・β細胞量との関連2018
- Author(s)
  稲石淳, 税所芳史, 向井直子, 平川洋一郎, 吉田大悟, 秦淳, 渡辺雄祐, 小田義直, 伊藤裕, 二宮利治
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08488
[Presentation] Effects of obesity and diabetes on delta and pancreatic polypeptide cell mass and the relative change among islet endocrine cell mass in humans2017
- Author(s)
  Watanabe Y, Saisho Y et al.
- Organizer
  77th Scientific Sessions of the American Diabetes Association (ADA) San Diego, CA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] ヒト膵脂肪含有量とα・β細胞量との関連についての検討2017
- Author(s)
  村上理恵、税所芳史、稲石淳、渡辺雄祐、土屋多美、佐藤誠治、侯金成、山田健人、北郷実、北川雄光、伊藤裕
- Organizer
  第60回日本糖尿病学会　名古屋
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] Relationship between intra-pancreatic fat content and beta and alpha cell mass in humans with and without diabetes2017
- Author(s)
  Murakami R, Saisho Y et al.
- Organizer
  77th Scientific Sessions of the American Diabetes Association (ADA) San Diego, CA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] 肥満、糖尿病におけるヒト膵δ・PP細胞量の変化についての検討2017
- Author(s)
  渡辺雄祐、税所芳史、稲石淳、村上理恵、土屋多美、佐藤誠治、侯金成、北郷実、北川雄光、山田健人、伊藤裕
- Organizer
  第60回日本糖尿病学会　名古屋
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] 肥満、糖尿病でのヒトα・β細胞量の変化についての検討2016
- Author(s)
  稲石淳、税所芳史、佐藤誠治、村上理恵、渡辺雄祐、侯金成、北郷実、北川雄光、山田健人、伊藤裕
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] Relathinship between intra-pancreatic fat content and beta and alpha cell mass in humans with and without diabetes2016
- Author(s)
  Murakami R, Saisho Y, Kou K, Sato S, Watanabe Y, Kitago M, Kitagawa Y, Yamada T, Itoh H
- Organizer
  52nd Annual Meeting of the European Association for the Study of Diabetes (EASD)
- Place of Presentation
  Munich, Germany
- Year and Date
  2016-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] ヒト膵脂肪含有量とα・β細胞量との関連についての検討2016
- Author(s)
  村上理恵、税所芳史、侯金成、佐藤誠治、稲石淳、渡辺雄祐、北郷実、北川雄光、山田健人、伊藤裕
- Organizer
  第34回日本肥満症治療学会学術集会
- Place of Presentation
  東京コンベンションセンター（東京都中央区）
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] 膵摘出例を用いた肥満、糖尿病でのヒトα・β細胞量の変化についての検討2016
- Author(s)
  渡辺雄祐、税所芳史、稲石淳、佐藤誠治、村上理恵、侯金成、北郷実、北川雄光、山田健人、伊藤裕
- Organizer
  第34回日本肥満症治療学会学術集会
- Place of Presentation
  東京コンベンションセンター（東京都中央区）
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] ヒト膵脂肪含有量とα・β細胞量との関連についての検討2016
- Author(s)
  村上理恵、税所芳史、稲石淳、渡辺雄祐、佐藤誠治、侯金成、山田健人、北郷実、北川雄光、伊藤裕
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] Effects of obesity and diabetes on alpha and beta cell mass in surgically removed human pancreas2015
- Author(s)
  Inaishi J, Saisho Y, Kou K, Sato S, Murakami R, Yamada T, Kitago M, Kitagawa Y, Itoh H
- Organizer
  51st Annual Meeting of the European Association for the Study of Diabetes (EASD)
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] 膵摘出症例におけるβ細胞量と糖代謝指標の関連についての検討2015
- Author(s)
  稲石淳、税所芳史、村上理恵、佐藤誠治、侯金成、北郷実、北川雄光、山田健人、伊藤裕
- Organizer
  第88回日本内分泌学会
- Place of Presentation
  ホテルニューオータニ東京（東京都千代田区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K09399
[Presentation] 肥満、糖尿病でのヒトα・β細胞量の変化についての検討2015
- Author(s)
  稲石淳、税所芳史、村上理恵、佐藤誠治、侯金成、北郷実、北川雄光、山田健人、伊藤裕
- Organizer
  第58回日本糖尿病学会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K09399

1. YAMADA Taketo (60230463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. SATO Seiji (90528762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. INAISHI Jun (60724565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
4. MURAKAMI Rie (40645719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
5. KITAGO Minoru (70296599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. YAMADA koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saisho Yoshifumi 税所 芳史

Research Projects

Research Products

Co-Researchers

Development of novel strategy for treatment of diabetes based on exploring of human beta cell regulatorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of human beta cell mass and its association with glucose tolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of human beta cell massPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dipeptidyl Peptidase-4 Inhibitors and Beta Cell Mass in Japanese Adults with Type 2 Diabetes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exenatide Once Weekly for Management of Type 2 Diabetes: A Review2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased alpha cell to beta cell ratio in patients with pancreatic cancer2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Revisiting Regulators of Human β-cell Mass to Achieve β-cell?centric Approach Toward Type 2 Diabetes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced beta cell number rather than size is a major contributor to beta cell loss in type 2 diabetes2021

Author(s)

Journal Title

Data Source

[Journal Article] Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Associations of birthweight and history of childhood obesity with beta cell mass in Japanese adults2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An emerging new concept for the management of type 2 diabetes with a paradigm shift from the glucose-centric to beta cell-centric concept of diabetes - an Asian perspective2020

Author(s)

Journal Title

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[Journal Article] Association of glucose tolerance status with pancreatic β‐ and α‐cell mass in community‐based autopsy samples of Japanese individuals: The Hisayama Study2020

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[Journal Article] Comprehensive study on human pancreatic beta-cell regulatory mechanism2019

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[Journal Article] Changing the Concept of Type 2 Diabetes: Beta Cell Workload Hypothesis Revisited2019

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[Journal Article] 膵α・β細胞容積2018

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Saisho Yoshifumi 税所芳史

[Journal Article] 2型糖尿病の発症メカニズム　膵β細胞workload仮説2017

[Presentation] 剖検例における耐糖能と膵β・α細胞量に関する検討　久山町研究2020