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HIGUCHI Teturo  樋口 哲郎

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… Alternative Names

樋口 哲朗  ヒグチ テツロウ

HIGUCHI Tetsuro  樋口 哲郎

樋口 哲郎  ヒグチ テツロウ

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Researcher Number 90334416
Affiliation (based on the past Project Information) *help 2009: 東京医科歯科大学, 医歯学総合研究科, 助教
2007 – 2008: 東京医科歯科大学, 大学院・医歯学総合研究科, 助教
2007: Tokyo Medical and Dental University, 医学部・附属病院, Assistant
2006: 東京医科歯科大学, 医学部附属病院, 助手
2005: 東京医科歯科大学, 医学部付属病院, 助手
2004: 東京医科歯科大学, 医学部附属病院, 医員
2002: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手
Review Section/Research Field
Except Principal Investigator
Digestive surgery / Digestive surgery
Keywords
Except Principal Investigator
lung metastasis / gastric cancer / colorectal cancer / COX-2 inhibitor / cyclooxygenase / COX-2 / COX2 / 大腸癌 / COX-2阻害剤 / NSAIDs … More / Cyclooxygenase-2 / iver metastasis / COX2阻害剤 / 血行性転移 / k-ras / 大腸発癌 / 肺転移 / 血管鋳型 / 血管新生 / 5-lipoxygenase / cyclooxygenase 2 / angiogenesis / live matastasis / liver metastasis / familial nolyposis coli / Colorectal cancer / colorectal adenoma / COX-2 Inhibitor / NSAID / 大腸腺種 / サイクロオキシゲナーゼ / 治療 / 癌 / 動物実験 / 大腸腺腫症 / 大腸腺腫 / 大腸線腫症 / 大腸線腫 / 化学療法 / 抗癌剤感受性 / 予後因子 / リアルタイムPCR / 遺伝子発現 / RT-PCR / マイクロアレイ / パラフィン包埋標本 / 大腸小腸肛門外科学 Less
  • Research Projects

    (3 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (9 People)
  •  Development and clinical application of cDNA microarray using formalin fixed paraffin embedded specimen

    • Principal Investigator
      UETAKA Hiroyuki (UETAKE Hiroyuki)
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  Cyclooxygenase-2 inhibitor is a possible new drug for treatment of gastrointestinal cancers

    • Principal Investigator
      SUGIHARA Kenichi
    • Project Period (FY)
      2004 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  Cyclooxygenase-2 in development of colorectal neoplasia and effect of cyclooxyhgenase-2 inhbitor on colorectal neoplasia

    • Principal Investigator
      SUGIHARA Kenichi
    • Project Period (FY)
      2000 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Tokyo Medical and Dental University

All 2008 2007 2006 2005 2004

All Journal Article Presentation Book

  • [Book] 期待される選択的COX-2阻害薬 選択的COX-2阻害薬のがん化学予防2007

    • Author(s)
      樋口哲郎、杉原健一
    • Total Pages
      5
    • Publisher
      治療学
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Book] 大腸癌の前癌病変とchemoprevention:家族性大腸腺腫症に対するCOX-2阻害薬の効果2005

    • Author(s)
      樋口哲郎、杉原健一
    • Total Pages
      7
    • Publisher
      日本メディカルセンター
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Book] COXinhibitorによる大腸癌のchemoprevention Pharma Medica2005

    • Author(s)
      樋口哲郎、杉原健一
    • Total Pages
      6
    • Publisher
      Pharma Medica
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis.2008

    • Author(s)
      Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Kuramochi H, Lenz HJ, Danenberg KD, Danenberg PV.
    • Journal Title

      Ann Surg Oncol 15

      Pages: 1232-1238

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390362
  • [Journal Article] Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis2008

    • Author(s)
      Kobayashi H, Sugihara K, Uetake H, Higuchi T, Yasuno M, Enomoto M, Kuramochi H, Lenz HJ, Danenberg KD, Danenberg PV.
    • Journal Title

      Ann Surg Oncol 15

      Pages: 1232-1238

    • Data Source
      KAKENHI-PROJECT-18390362
  • [Journal Article] The effect of Meloxicam, a selective COX-2 inhibitor, on the microvascularture of small metastatic liver tumors in rats2007

    • Author(s)
      Iwasse N, Higuchi T, Gond a T, Kobayashi H, Uetake H, Enomoto M, Sugihara K
    • Journal Title

      Jpn J CIini Oncol 9

      Pages: 673-678

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Absence of Cyclooxygenase-2 protein expression is a predictor of tumr regression in rectal cancer treated with preoperative short-term chemotherapy2007

    • Author(s)
      Kobayashi H, Hashiguchi Y, Ueno H, Shinto E, Kajiwara Y, Mochizuki H.
    • Journal Title

      Dis Colon Rectum 9

      Pages: 1354-1362

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] The effect of meloxicam, a selective COX-2 inhibitor, on the microvasculature of small metastatic liver tumors in rats2007

    • Author(s)
      Iwase N, Higuchi T, Gonda T, Kobayashi H, Uetake H, Enomoto M, Sugihara K
    • Journal Title

      Jpn J Clin Oncol. 37(9)

      Pages: 673-8

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] The effect of meloxicam, a selective COX-2 inhibitor, on the microvasculature of small metastatic liver tumors in rats2007

    • Author(s)
      Iwase N, Higuchi T, Gonda T, Kobayashi H, Uetake H, Enomoto M, Sugihara K.
    • Journal Title

      Jpn J Clin Oncol 37(9)

      Pages: 673-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Absence of Cyclooxygenase-2 Protein Expression is a predictor of Tumor Regression in Rectal Cancer Treated with Preoperative Short-Term Chemoradiotherapy2007

    • Author(s)
      Kobayashi H, Hashiguchi Y, Ueno H, Shinto E, Kajiwara Y, Mochizuki H
    • Journal Title

      Dis Colon Rectum. 50(9)

      Pages: 1354-62

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] The effect of a selective COX-2 inhibitor, Meloxicam, on the microvascularture of small metastatic liver tumors in rats2007

    • Author(s)
      Iwase N, Gonda T, Kobayashi H, Uetake H, Enomoto M, Higuchi T, Sugihara K
    • Journal Title

      Jpn J Clin Oncol (In press)

    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] 大腸癌治療に関する最新のデータ2007

    • Author(s)
      植竹宏之、榎本雅之、樋口哲郎、安野正道、飯田聡、小林宏寿、石川敏昭、石黒めぐみ、杉原健一
    • Journal Title

      臨床外科

      Pages: 349-353

    • Data Source
      KAKENHI-PROJECT-18390362
  • [Journal Article] Absence of Cyclooxygenase-2 Protein Expression is a Predictor of Tumor Regression in Rectal Cancer Treated with Preoperative Short-Term Chemoradiotherapy2007

    • Author(s)
      Kobayashi H, Hashiguchi Y, Ueno H, Shinto E, Kajiwara Y, Mochizuki H.
    • Journal Title

      Dis Colon Rectum 50(9)

      Pages: 1354-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Coexpression of VEGF-C and Cox-2 in Human Colorectal Cancer and its Association With Lymph Node Metastasis2006

    • Author(s)
      Soumaoro LT, Uetake H, Takagi Y, Iida S, Higuchi T, Yasuno M, Enomoto M, Sugihara K
    • Journal Title

      Dis Colon Rectum 49(3)

      Pages: 392-398

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis2006

    • Author(s)
      Soumaoro LT, Uetake H, Takaagi Y, Iida S, Higuchi T, Yasuno M, Enomoto M, Sugihara K
    • Journal Title

      Diseases of the colon & Rectum 49

      Pages: 1-7

    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Expression of 5-Lipoxygenase in human colorectal cancer2006

    • Author(s)
      Soumaoro LT, Iida S, Uetake H, Ishiguro M, Takagi Y, Higuchi T, Yasuno M, Enomoto M, Sugihara K.
    • Journal Title

      World J Gastroenterol 12(39)

      Pages: 6355-6360

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Coexpression of VEGF-C and Cox-2 in Human Colorectal Cancer and its Association With Lymph Node Metastasis2006

    • Author(s)
      Soumaoro LT, Uetake H, Takagi Y, Iida S, Higuchi T, Yasuno M, Enomoto M, Sugihara K.
    • Journal Title

      Dis Colon Rectum 49(3)

      Pages: 392-398

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Expression of 5-Lipoxygenase in human colorectal cancer2006

    • Author(s)
      Soumaoro LT, Iida S, Uetake H, Ishiguro M, Takagi Y, Higuchi T, Yasuno M, Enomoto M, Sugihara K
    • Journal Title

      World J Gastroenterol 12(39)

      Pages: 6355-6360

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] JTE-522 a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats2005

    • Author(s)
      Kobayashi H, Uetake H, Higuchi T, Enomoto M, Sugihara K
    • Journal Title

      BMC Cancer 5

      Pages: 1471-2407

    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats2005

    • Author(s)
      Kobayasi H, Uetake H, Higuchi T, Enomoto M, Sugihara K
    • Journal Title

      BMC Cancer 5

      Pages: 26-26

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats2005

    • Author(s)
      Kobayashi H, Uetake H, Higuchi T, Enomoto M, Sugihara K.
    • Journal Title

      BMC Cancer 5

      Pages: 26-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] JTE-522 a selective COX-2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization : a vascular cast model study2004

    • Author(s)
      Kobayashi H, Gonda T, Uetake H, Higuchi T, Enomoto M, Sugihara K.
    • Journal Title

      Int J Cancer 112

      Pages: 920-926

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] JTE-522 a selective COX-2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: a vascular cast model study2004

    • Author(s)
      Kobayashi H, Gonda T, Uetake H, Higuchi T, Enomoto M, Sugihara K
    • Journal Title

      Int J Cancer 112

      Pages: 920-926

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Cyclooxygenase-2 overexpression is related to polypoid growth and k-ras gene mutation in T1 colorectal carcinoma2004

    • Author(s)
      Okawa T, Yoshinaga K, Uetake H, Sato T, Higuchi T, Nemoto T, Sugihara K.
    • Journal Title

      Dis Colon Rectum 47(11)

      Pages: 1915-1921

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Cyclooxygenase-2 expression : a significant prognostic indicator for patients with colorectal cancer2004

    • Author(s)
      Soumaoro Labile Togba, Uetake H, Higuchi T, Takagi Y, Enomoto M, Sugihara K.
    • Journal Title

      Clin Cancer Res 10(24)

      Pages: 8465-71

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Cyclooxgenase-2 expression : a significant indicator for patients with colorectal cancer2004

    • Author(s)
      Soumaoro LT, Uetake H, Higuchi T, Sugihara K
    • Journal Title

      Clin Cancer Res 10

      Pages: 8465-8471

    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer2004

    • Author(s)
      Soumaoro Labile Togba, Uetake H, Higuchi T, Takagi Y, Enomoto M, Sugihara K
    • Journal Title

      Clin Cancer Res 10(24)

      Pages: 8465-71

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] 家族性大腸腺腫症患者の直腸病変に対するCOX-2選択的阻害剤rofecoxibによる二重盲検比較試験2004

    • Author(s)
      樋口哲郎、杉原健一
    • Journal Title

      消化器外科 38(6)

      Pages: 556-562

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Journal Article] Cyclooxygenase-2 overexpression is related to polypoid growth and k-ras gene mutation in T1 colorectal carcinoma2004

    • Author(s)
      Okawa T, Yoshinaga K, Uetake H, Sato T, Higuchi T, Nemoto T, Sugihara K
    • Journal Title

      Dis Colon Rectum 47(11)

      Pages: 1915-1921

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Presentation] 大腸癌原発巣と肝転移巣における血管新生関連遺伝子の発現Laser capture microdissection および real-time RT-PCRによる検討2007

    • Author(s)
      小林宏寿、植竹宏之、樋口哲郎、飯田聡、安野正道、榎本雅之、Kathleen Danenberg、Peter Danenberg、杉原健一
    • Organizer
      サージカルフォーラム第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-11
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Presentation] The effect of JTE-522, a selective COX-2 inhibitor, on micr ovasculature of pulmonary metastasis from colorectal cancer in rats: A vascular cast model study2004

    • Author(s)
      Kobayashi H, Uetake H, Higuchi T, Enomoto M, Sugihara K
    • Organizer
      95th Annual Meeting of American Associ ation for Cancer Research
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2004-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • [Presentation] The effect of JTE-522, a selective COX-2 inhibitor, on microvasculature of pulmonary metastasis from colorectal cancer in rats : A vascular cast model study2004

    • Author(s)
      Kobayashi H, Uetake H, Higuchi T, Enomoto M, Sugihara K.
    • Organizer
      95th Annual Meeting of American Association for Cancer Research
    • Place of Presentation
      USA, Orlando.
    • Year and Date
      2004-03-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390374
  • 1.  UETAKA Hiroyuki (60311651)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 25 results
  • 2.  SUGIHARA Kenichi (10171167)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 29 results
  • 3.  ENOMOTO Masayuki (60301165)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 19 results
  • 4.  IIDA Satoshi (20361694)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  ISHIKAWA Tosiaki (00422478)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  YOSHIMURA Tetsunori (00431908)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KOBAYASHI Hirotoshi (70451953)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 14 results
  • 8.  吉永 圭吾 (80240745)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  角崎 秀文 (60372447)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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