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MASAYASU Okochi  大河内 正康

ORCIDConnect your ORCID iD *help
Researcher Number 90335357
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2016 – 2019: 大阪大学, 医学系研究科, 講師
2015: 大阪大学, 医学研究科, 講師
2011 – 2015: 大阪大学, 医学(系)研究科(研究院), 講師
2013: 大阪大学, 大学院医学系研究科, 講師
2010 – 2012: 大阪大学, 医学系研究科, 講師 … More
2010: 大阪大学, 大学院・医学系研究科, 講師
2007 – 2009: Osaka University, Graduate School of Medicine, Assistant Professor
2007: 大阪大学, 医学系・研究科, 助教
2002 – 2006: 大阪大学, 医学系研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Psychiatric science / Biological Sciences / Psychiatric science
Except Principal Investigator
Psychiatric science / Psychiatric science
Keywords
Principal Investigator
アルツハイマー病 / アミロイドβ蛋白 / γセクレターゼ / プレセニリン / Notchシグナル伝達 / Notch-1 / 精神神経科学 / 老人斑 / γ切断 / βアミロイド蛋白前駆体 … More / 患者細胞 / アミロイドβペプチド / ゲノム編集技術 / iPS技術 / γ-cleavage / βAPP / Amyloid-β peptide / Notch signaling / γ-secretase / presenilin / Alzheimer's disease / 膜内タンパク分解 / Aβ / 酵素と基質の解離 / 膜内蛋白分解 / 超微量物質定量 / バイオマーカー / プロテオームリサーチ / LC/MS/MS / 精神疾患 / 神経変性疾患 / アミノ酸配列決定 / ペプチド / 質量分析解析 / 精神神経疾 / 疾患関連物質探索 / 質量分析 / 脳脊髄液 / 質量分析法 / 精神神経疾患 / サロゲートマーカー / 不溶性蛋白 / APLP1 / Notch1 / Notch-1-β peptide / CTF_γ / CTFγ / ATP依存的蛋白分解 / CD44 Aβ-like peptide / CD44 / Notch-1 Aβ-like peptide … More
Except Principal Investigator
アルツハイマー病 / Alzheimer disease / BACE / アポトーシス / アミロイドβ / γセクレターゼ / cell-free BACE assay / Notch-1 / プレセニリン / gamma secretase / NSAID / Presenilin / ガンマセクレターゼ / アミロイドベータの分解 / endoplasmic reticulum stress / APP / 分子シャペロン / 神経細胞死 / 神経原線維変化 / タウオパチー / タウ蛋白 / Z-DNA / γ切断 / バイオマーカー / 脳神経疾患 / アミロイド / APLP1 / amyloid beta / presenilin / Treatment / micro glia / Inflammation / イブプロフェン / ワクチン療法 / マイクログリア / 抗炎症剤 / amvloid beta / apoptosis / cerebral ischemia / chaperone / amyloid apoptosis / 脳虚血 / アミロイド前駆蛋白(APP) / アミロイド蛋白(Aβ) / 小胞体(ER)ストレス / gamma-cleavage / beta-amyloid protein precursor / Amyloid-beta peptide / Notch signaling / gamma-secretase / βアミロイド蛋白前駆体 / アミロイドβ蛋白 / Notchシグナル伝達 / γ-secretase / Aβ degradation / )cell-free BACE assay / molecular chaperone / β-amyloid / プロテオソーム / カスペース / Aβ / ストレス / 小胞体 / 小胞体ストレス / アミロイド蛋白 / Microtubule / Ribosome / Apoptosis / Tau Protein / Alzheimer Disease / XIAP(X染色体関連アポトーシス阻害蛋白) / 微小管 / リボソーム / neurofibilliary tangles / double stranded RNA / tauopathy / neuronal cell death / tau Protein / リボトキシックストレス / 2本鎖RNA / リン酸化 / spricing / microsatellite / Alzheimer desease / Apolipoprotein C-II / Apolipoprotein A-II / アポリポ蛋白E / アルブミン / シスタチオニンβシンターゼ / スプライシング / マイクロサテライト / アポリポ蛋白C-II / アポリポ蛋白A-II / アルツハイマー病バイオマーカー / APL1β / γ‐セクレターゼ / CRISPR/CAS9 / γ-セクレターゼ / 脳脊髄液 / 神経変性疾患 / APL1ベータペプチド / アミロイドベータ産生機構 / 質量分析 / セクレターゼ / βAPP / GSM / Notchシグナル / MCSF / beta APP / アミロイドベータ / betaAPP Less
  • Research Projects

    (23 results)
  • Research Products

    (347 results)
  • Co-Researchers

    (14 People)
  •  幹細胞技術と遺伝子編集技術を組み合わせアルツハイマー病治療戦略を洗練させるPrincipal Investigator

    • Principal Investigator
      大河内 正康
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Intramembrane proteolysis of beta-APP in a gamma-secretase independent mechanism

    • Principal Investigator
      Yanagida Kanta
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Mechanism of presenilin/gamma secretase to produce amyloid beta

    • Principal Investigator
      Tagami Shinji
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Identification of molecules related to modulation of Amyloid beta production in human cerebrospinal fluid (CSF)

    • Principal Investigator
      Takashi Kodama
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Increase in Abeta42 production and accelerated dissociation of Abeta42 from gamma-secretasePrincipal Investigator

    • Principal Investigator
      Okochi Masayasu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Analysis of presenilin gamma-secretase function on Abeta and NICD generation

    • Principal Investigator
      TAGAMI Shinji
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Analysis of novel Alzheimer's disease-related peptides in human cerebrospinal fluid derived from APLP2

    • Principal Investigator
      YANAGIDA Kanta
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Mass spectrometry analysis of human cerebrospinal fluid with psychiatric disease patients.Principal Investigator

    • Principal Investigator
      OKOCHI Masayasu
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Development of methods to promote degradation of amyloid beta

    • Principal Investigator
      TAGAMI Shinji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Characterization of Abeta-like peptide other in brains of Alzheimer diseasePrincipal Investigator

    • Principal Investigator
      MASAYASU Okochi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Characterization of BACE-mediated proteolysis including amyloid-beta

    • Principal Investigator
      TAGAMI Shinji
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  The mechanisms of anti-Alzheimer dicaam effects by NSAIDs

    • Principal Investigator
      TAKASHI Morihara
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Analysis of sequential endoproteolytic process of beta-APP to establish novel therapeutic interventions

    • Principal Investigator
      TAKEDA Masatoshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Implication of ER stress in amyloid production and its application for therapeutic approach

    • Principal Investigator
      KUDO Takashi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Degradation of amyloid-beta

    • Principal Investigator
      TAGAMI Shinji
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Measurement of novel Nβ species level as a substitute for Aβ species.Principal Investigator

    • Principal Investigator
      OKOCHI Masayasu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Notch-βペプチドを孤発性アルツハイマー病マーカーとして開発できるかPrincipal Investigator

    • Principal Investigator
      大河内 正康
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  Neurodegenerative mechanism on ribotoxic stress and apoptosis

    • Principal Investigator
      TAKEDA Masatoshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Molecular mechanism of endoplasmic reticulum stress and Alzheimer disease

    • Principal Investigator
      KUDO Takashi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  活性中心を分子内移動させた人工プレセニリン発現によりAPPγ切断部位は変化するかPrincipal Investigator

    • Principal Investigator
      大河内 正康
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  アミロイドβ蛋白前駆体の膜内γ切断はエネルギー依存的かPrincipal Investigator

    • Principal Investigator
      大河内 正康
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Modification of genetic expression by intoronic microsatellite in risk genes of Alzheimer's disease

    • Principal Investigator
      KAMINO Kouzin
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University
  •  Mechanism of the nerve cell death accompanied with tau protein phosphorylation in tauopathy

    • Principal Investigator
      TANAKA Toshihisa
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Psychiatric science
    • Research Institution
      Osaka University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] 日本発Aβ42サロゲートマーカーの発見と性質 ― アルツハイマー病の発症前診断マーカーへの応用の可能性2013

    • Author(s)
      大河内正康
    • Total Pages
      10
    • Publisher
      精神神経学雑誌
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] アミロイドカスケードの異常を反映するAβ42サロゲートマーカーAPL1β282013

    • Author(s)
      大河内正康
    • Total Pages
      10
    • Publisher
      老年精神医学
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] アルツハイマー病バイオマーカーについて2012

    • Author(s)
      大河内正康
    • Total Pages
      10
    • Publisher
      脳21
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] アルツハイマー病薬開発の現状2012

    • Author(s)
      大河内正康
    • Total Pages
      10
    • Publisher
      脳21
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] 認知症学-その解明と治療の最新知見III.臨床編認知症の症候学各論2011

    • Author(s)
      大河内正康, 武田雅俊
    • Publisher
      (株)日本臨牀社
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] プレセニリン研究の過去と現在2010

    • Author(s)
      大河内正康、武田雅俊
    • Publisher
      老年精神医学雑誌
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] 神経内科 第72巻特別増刊号 認知症診断マニュアル総論的事項-アルツハイマー病の病理過程の理解と治療薬開発 (Aβカスケード、神経栄養因子、神経伝達物質)2010

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Total Pages
      5
    • Publisher
      科学評論者
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Book] 今、開発されている認知症(アルツハイマー病)の根本治療薬は?2010

    • Author(s)
      大河内正康
    • Publisher
      日本医事新報社
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] 新老年学第3版アルツハイマー型認知症2010

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Book] アルツハイマー病Abeta42のサロゲートマーカーAPL1beta28ペプチドの発見:孤発性アルツハイマー病患者脳でAbeta42の産生増大が起こっている可能性について2010

    • Author(s)
      大河内正康、田上真次、柳田寛太、武田雅俊
    • Publisher
      日本神経精神薬理学雑誌
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] アルツハイマー病老人班に蓄積するAbeta42産生の仕組みはどこまでわかったか?また、その成果の臨床応用の可能性について2010

    • Author(s)
      大河内正康、武田雅俊
    • Publisher
      金芳堂脳21
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] 中核症状と周辺症状-アルツハイマー病アップデート2010

    • Author(s)
      大河内正康、武田雅俊
    • Publisher
      中外医学社 Clinical Neuroscience
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] 新規脳内ペプチドAPL1beta28の測定結果からアルツハイマー病をみる2010

    • Author(s)
      大河内正康、田上真次、柳田寛太、武田雅俊
    • Publisher
      メディカルレビュー社 Pharma Medica
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Book] 神経内科第72巻特別増刊号認知症診断マニュアル総論的事項-アルツハイマー病の病理過程の理解と治療薬開発(Aβカスケード、神経栄養因子、神経伝達物質)2010

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Publisher
      科学評論者
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Book] 新老年学 第3版アルツハイマー型認知症2010

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Total Pages
      9
    • Publisher
      東京大学出版会
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Book] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008

    • Author(s)
      Okochi, M., Tagami, S., Takeda, M
    • Total Pages
      94
    • Publisher
      Annual Report of Osaka University Academic Achievement 2007-2008
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Book] アルツハイマー病の薬物療法の実際2008

    • Author(s)
      大河内正康、武田雅俊
    • Publisher
      カレントテラピー
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Book] プレセニリンγセクレターゼによる切断の多様性とその変化について2008

    • Author(s)
      田上真次, 大河内正康, 福森亮雄, 武田雅俊
    • Publisher
      分子精神医学先端医学社
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Book] プレセニリンγセクレターゼによる切断の多様性とその変化について2008

    • Author(s)
      田上真次 大河内正康 福森亮雄武田雅俊
    • Total Pages
      4
    • Publisher
      分子精神医学先端医学社
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Book] アンチエイジングと精神医学2007

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Publisher
      Journal of Otolaryngology, Head and Neck Surgery東京医学社
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Book] 老年期認知症ナビゲーター2006

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Total Pages
      2
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Book] BACEによるアミロイドベータ蛋白の切断について2006

    • Author(s)
      田上真次, 大河内正康, 武田雅俊ほか
    • Total Pages
      230
    • Publisher
      精神薬療研究年報 第38集
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Book] 脳と循環2006

    • Author(s)
      大河内 正康, 田上 真次, 武田 雅俊
    • Total Pages
      13
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Book] 老年期認知症ナビゲーター2006

    • Author(s)
      大河内 正康, 田上 真次, 武田 雅俊
    • Total Pages
      2
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Book] 脳と循環2006

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Total Pages
      13
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Book] アルツハイマー病 : 治療の可能性を探る「アミロイドβタンパク質産生の異常がアルツハイマー病につながる」2005

    • Author(s)
      大河内正康
    • Publisher
      クバプロ
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Book] Recent Progress in Alzheimer's and Parkinson's Disease2005

    • Author(s)
      T.Kudo, T.Katayama, K.Imaizumi, D.Kanayama, J.Hitomi, M.Okochi, M.Tohyama, M.Takeda
    • Total Pages
      383
    • Publisher
      Alzheimer pathology and endoplasmic reticulum stress
    • Data Source
      KAKENHI-PROJECT-17591210
  • [Book] アルツハイマー病:治療の可能性を探る 2005 第19回「大学と科学」公開シンポジウム講演抄録集2005

    • Author(s)
      大河内正康
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Book] 痴呆とうつ 心療内科2005

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Publisher
      科学評論社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Book] アルツハイマー病:治療の可能性を探る 2005 第19回「大学と科学」公開シンポジウム講演抄録集(単行本)2005

    • Author(s)
      大河内正康
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Book] 日本医師会雑誌131巻、第12号、特別号 精神障害の臨床 アルツハイマー病の分子病態2004

    • Author(s)
      大河内正康, 武田雅俊
    • Publisher
      日本医師会
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Book] 日本臨床62巻 増刊号1,痴呆症侯学(2)臨床編 アミロイド前駆体蛋白遺伝子変異によるアルツハイマー病2004

    • Author(s)
      大河内正康, 武田雅俊
    • Publisher
      日本臨床
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Book] Molecular Neurobiology of Alzheimer Disease and Related Disorders "Alzheimer's γ-secretase mechanism produces Amyloid-β-protein like peptides simultaneously with release of intracellular signaling fragments"2004

    • Author(s)
      Okochi, M., Fukumori, A., Satoh, Y., Aidaralieva, N., Tanii, H., Kamino, K., Tanaka, T., Kudo, T., Takeda M.
    • Publisher
      Karger Press
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Book] Molecular Medicine 41 Aβの毒性発現機構2004

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Book] Psychiatry Today, No.4 アルツハイマー病の診断バイオマーカーの新たなコンセプト:Aβ様ペプチド2004

    • Author(s)
      Okochi, M.
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Book] Molecular Newrobiology of Alzheimer Disease and Related Disorders, Alzheimer's γ-secretase mechanism produces Amyloid-β-protein like peptides simultaneously with release of intracellular signaling fragments2004

    • Author(s)
      Okochi, M., Fukumori, A., et al.
    • Publisher
      Karger Press
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Presenilin 1 Regulates NF-κB Activation via Association with Breakpoint Cluster Region and Casein Kinase II.2018

    • Author(s)
      Tanaka Y, Sabharwal L, Ota M, Nakagawa I, Jiang JJ, Arima Y, Ogura H, Okochi M, Ishii M, Kamimura D, Murakami M.
    • Journal Title

      J Immunol.

      Volume: 201(8) Issue: 8 Pages: 2256-2263

    • DOI

      10.4049/jimmunol.1701446

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10299, KAKENHI-PROJECT-17K19537
  • [Journal Article] Identification of small peptides in human cerebrospinal fluid upon amyloid-βdegradation2017

    • Author(s)
      Mizuta N, Yanagida K, Kodama T, Tomonaga T, Takami M, Oyama H, Kudo T, Ikeda M, Takeda M, Tagami S, Okochi M
    • Journal Title

      Neurodegener Dis

      Volume: 17 Issue: 2-3 Pages: 103-109

    • DOI

      10.1159/000453358

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24249100, KAKENHI-PROJECT-26461746
  • [Journal Article] Semagacestat Is a Pseudo-Inhibitor of γ-Secretase2017

    • Author(s)
      Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M.
    • Journal Title

      Cell Rep

      Volume: 21 Issue: 1 Pages: 259-273

    • DOI

      10.1016/j.celrep.2017.09.032

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10213, KAKENHI-PROJECT-17K10299, KAKENHI-PROJECT-16H05379, KAKENHI-PROJECT-26461745
  • [Journal Article] 最新のアルツハイマー病の血液バイオマーカー開発2016

    • Author(s)
      田上 真次 大河内 正康
    • Journal Title

      医学のあゆみ

      Volume: 257 Pages: 519-524

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Journal Article] 認知症のバイオマーカー ―髄液ならびに血液―2016

    • Author(s)
      田上 真次 大河内 正康
    • Journal Title

      臨床精神医学

      Volume: 45 Pages: 405-410

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Journal Article] γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.2014

    • Author(s)
      Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M.
    • Journal Title

      J Biol Chem.

      Volume: 289 Issue: 8 Pages: 51095121-51095121

    • DOI

      10.1074/jbc.m113.510131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-24500433
  • [Journal Article] Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor2014

    • Author(s)
      Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, Hara H, Imaizumi K, Maurice T, Chevallier N, Marchal S, Takeda M, Kudo T
    • Journal Title

      Cell Death and Disease

      Volume: 5 Issue: 7 Pages: 1-11

    • DOI

      10.1038/cddis.2014.301

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25461729, KAKENHI-PROJECT-26461746
  • [Journal Article] γ-Secretase associated with lipid rafts : multiple interactive pathways in the stepwise processing ofβ-carboxyl-terminal fragment2014

    • Author(s)
      Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M
    • Journal Title

      J Biol Chem

      Volume: Vol.289 Pages: 5109-5121

    • Data Source
      KAKENHI-PROJECT-23591703
  • [Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-βaccumulation modifier2014

    • Author(s)
      Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: Vol.111 Pages: 2638-2643

    • Data Source
      KAKENHI-PROJECT-23591703
  • [Journal Article] Relative Ratio and Level of Amyloid-β 42 Surrogate in Cerebrospinal Fluid of Familial Alzheimer Disease Patients with Presenilin 1 Mutations2014

    • Author(s)
      Tagami et al.
    • Journal Title

      Neurodegenerative Disease

      Volume: 13 Issue: 2-3 Pages: 166-170

    • DOI

      10.1159/000355258

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23591234, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26461733, KAKENHI-PROJECT-26461746
  • [Journal Article] Absolute Quantitation of Low Abundance Plasma APL1βpeptides at Sub-fmol/mL Level by SRM/MRM without Immunoaffinity Enrichment2014

    • Author(s)
      Sano S, Tagami S, Hashimoto Y, Yoshizawa-Kumagaye K, Tsunemi M, Okochi M, Tomonaga T
    • Journal Title

      J Proteome Res

      Volume: Vol.13 Pages: 1012-1020

    • Data Source
      KAKENHI-PROJECT-23591703
  • [Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as as amyloid beta accumulation modifier2014

    • Author(s)
      Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, MA., Kimura, N., Saito, Y., Suzuki, T., Yanagida, K., Tanaka, T., Kazui, H., Kudo, T., Kodama, TS., Sato, M., Hashimoto, R., Tagami, S., Okochi, M., Ytoh, N., Nishitomi, K., Takamura, H., Katayama, T., Hashizumi, Y., Kimura, R., Kamino, K., Takeda, M
    • Journal Title

      Proc. Acad. Natl. Sci. USA

      Volume: 111 Issue: 7 Pages: 2638-2643

    • DOI

      10.1073/pnas.1307345111

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-23791332, KAKENHI-PROJECT-24591708, KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25290039, KAKENHI-PROJECT-25293250, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-26461746, KAKENHI-PROJECT-26461747
  • [Journal Article] Absolute Quantitation of Low Abundance Plasma APL1β peptides at Sub-fmol/mL Level by SRM/MRM without Immunoaffinity Enrichment.2013

    • Author(s)
      Sano S, Tagami S, Hashimoto Y, Yoshizawa-Kumagaye K, Tsunemi M, Okochi M, Tomonaga T.
    • Journal Title

      J Proteome Res.

      Volume: 13 Issue: 2 Pages: 10121020-10121020

    • DOI

      10.1021/pr4010103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-25290054
  • [Journal Article] γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43.2013

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M.
    • Journal Title

      Cell Reports

      Volume: 3 Pages: 4251-4251

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia.2013

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M.
    • Journal Title

      World J Biol Psychiatry

      Volume: 14 Pages: 100-13

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Involvement of endoplasmic reticulum stress in tauopathy.2013

    • Author(s)
      Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 430(2) Issue: 2 Pages: 500-4

    • DOI

      10.1016/j.bbrc.2012.12.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284, KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-25461729, KAKENHI-PROJECT-25650069
  • [Journal Article] γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ432013

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M
    • Journal Title

      Cell Reports

      Volume: Vol.3 Pages: 42-51

    • Data Source
      KAKENHI-PROJECT-23591703
  • [Journal Article] γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.2013

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M.
    • Journal Title

      Cell Rep.

      Volume: 3(1) Issue: 1 Pages: 42-51

    • DOI

      10.1364/oe.21.000322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] γ -secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ432013

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takami M,Kodama TS, Mori K, Nakayama T, Ihara Y,Takeda M
    • Journal Title

      Cell Rep

      Volume: 3 Pages: 42-51

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Non-pharmacological intervention for dementia patients2012

    • Author(s)
      Takeda M, Tanaka T, Okochi M, Kazui H
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66 Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Non-pharmacological intervention for dementia patients2012

    • Author(s)
      Takeda M, Tanaka T, Okochi M, Kazui H
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66(1) Issue: 1 Pages: 1-7

    • DOI

      10.1111/j.1440-1819.2011.02304.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591514, KAKENHI-PROJECT-22591284
  • [Journal Article] Non-pharmacological intervention for dementia patients.2012

    • Author(s)
      Takeda M, Tanaka T, Okochi M, Kazui H
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 66 Pages: 1-7

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Ab40/42 production detected using fusion constructs2012

    • Author(s)
      Sato N
    • Journal Title

      PLoS One

      Volume: 7 Issue: 11 Pages: e48551-e48551

    • DOI

      10.1371/journal.pone.0048551

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390222, KAKENHI-PROJECT-22591284, KAKENHI-PROJECT-23390187, KAKENHI-PROJECT-23590874, KAKENHI-PROJECT-24659349
  • [Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs2012

    • Author(s)
      Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R.
    • Journal Title

      PLoS One

      Volume: 7

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.2011

    • Author(s)
      Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 415 Issue: 3 Pages: 519-525

    • DOI

      10.1016/j.bbrc.2011.10.113

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2011

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
    • Journal Title

      World J Biol Psychiatry.2011 Dec 12

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.2011

    • Author(s)
      Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
    • Journal Title

      Psychogeriatrics.

      Volume: 11 Issue: 2 Pages: 90-97

    • DOI

      10.1111/j.1479-8301.2011.00355.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-23591706
  • [Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress2011

    • Author(s)
      Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: Vol.415 Pages: 519-525

    • Data Source
      KAKENHI-PROJECT-23591703
  • [Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress2011

    • Author(s)
      Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 415 Pages: 519-25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Involvement of endoplasmic reticulum stress in tauopathy.2011

    • Author(s)
      Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 430 Pages: 500-4

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population.2011

    • Author(s)
      Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
    • Journal Title

      World J Biol Psychiatry

      Volume: 11 Pages: 852-7

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death2011

    • Author(s)
      Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M
    • Journal Title

      Psychogeriatrics

      Volume: Vol.11 Pages: 90-97

    • Data Source
      KAKENHI-PROJECT-23591703
  • [Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.2011

    • Author(s)
      Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
    • Journal Title

      Psychogeriatrics

      Volume: 11 Pages: 90-7

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] New drugs for Alzheimer's disease in Japan2011

    • Author(s)
      Takeda M, Tanaka T, Okochi M.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 65 Pages: 399-404

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.2011

    • Author(s)
      Sigma-1Rs are upregulated via Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 415 Pages: 519-25

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] [Behavioral and psychological symptoms of dementia]2011

    • Author(s)
      Okochi M, Takeda M
    • Journal Title

      Nihon Rinsho.

      Volume: 8 Pages: 308-12

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010

    • Author(s)
      Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 30 Pages: 302-308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010

    • Author(s)
      Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S,Morihara T, Hashimoto R, Cacabelos R.
    • Journal Title

      Psychiatry Clin Neurosci 64

      Pages: 592-607

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Human B2 inhibitgamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010

    • Author(s)
      Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
    • Journal Title

      J Biol Chem 285

      Pages: 14290-14931

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010

    • Author(s)
      Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 30 Pages: 302-308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010

    • Author(s)
      Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
    • Journal Title

      Psychogeriatrics

      Volume: 10 Pages: 117-123

    • NAID

      10029771051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010

    • Author(s)
      Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 64 Pages: 592-607

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.2010

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S
    • Journal Title

      Schizophr Res.

      Volume: 116 Pages: 126-32

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients.2010

    • Author(s)
      Okochi M, Tagami S, Takeda M
    • Journal Title

      Neurodegener Dis.

      Volume: 7 Pages: 42-5

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010

    • Author(s)
      Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
    • Journal Title

      Psychogeriatrics

      Volume: 10 Pages: 117-123

    • NAID

      10029771051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Apolipoprotein E and central nervous system disorders: reviews of clinical findings.2010

    • Author(s)
      Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 64 Pages: 592-607

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010

    • Author(s)
      Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
    • Journal Title

      BMC Complement Altern Med.

      Volume: 10 Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients2010

    • Author(s)
      Okochi, M., Tagami, S., Takeda, M.
    • Journal Title

      Neurodegenerative Dis 7

      Pages: 42-45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010

    • Author(s)
      Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
    • Journal Title

      J Biol Chem.

      Volume: 285 Pages: 14920-31

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010

    • Author(s)
      Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 64 Pages: 592-607

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010

    • Author(s)
      Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
    • Journal Title

      BMC Complement Altern Med. 10

      Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010

    • Author(s)
      Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
    • Journal Title

      BMC Complement Altern Med.

      Volume: 10 Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010

    • Author(s)
      Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, FujiiK, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Take da M.
    • Journal Title

      Psychogeriatrics.

      Volume: 10 Pages: 117-23

    • NAID

      10029771051

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article]2010

    • Author(s)
      Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
    • Journal Title

      Dement Geriatr Cogn Disord 30

      Pages: 302-308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010

    • Author(s)
      Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 14290-14931

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.2010

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet.

      Volume: 153 Pages: 1459-64

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010

    • Author(s)
      Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 14290-14931

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010

    • Author(s)
      Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T
    • Journal Title

      Dement Geriatr Cogn Disord.

      Volume: 30 Pages: 302-8

    • Data Source
      KAKENHI-PROJECT-22591284
  • [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010

    • Author(s)
      Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
    • Journal Title

      Psychogeriatrics 10

      Pages: 117-123

    • NAID

      10029771051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor.2009

    • Author(s)
      Itoh N, Okochi, M., Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
    • Journal Title

      Neurodegenerative Dis 6

      Pages: 230-239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Takeda, M. Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients2009

    • Author(s)
      Okochi, M., Tagami, S.
    • Journal Title

      Neurodegenerative Dis 7

      Pages: 42-45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system.2009

    • Author(s)
      Yanagida K, Okochi, M., Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
    • Journal Title

      EMBO Molecular Medicine 1

      Pages: 223-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor2009

    • Author(s)
      Itoh N, Okochi, M., Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
    • Journal Title

      Neurodegenerative Dis 6

      Pages: 230-239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system2009

    • Author(s)
      Yanagida K, Okochi, M., Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
    • Journal Title

      EMBO Molecular Medicine 1

      Pages: 223-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008

    • Author(s)
      Okochi, M., Tagami, S., Takeda, M.
    • Journal Title

      Annual Report of Osaka University Academic Achievement 2007-2008 9

      Pages: 94-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Difficulty identifying spinocerebellar ataxia 17 from precedingric symptoms2008

    • Author(s)
      Ohi K, Hashimoto R, Sugai F, Yasuda Y, Tagami s, Takamura H, Morihara T, Okochi M, Tanaka T, Kudo T, Sakoda s, Takeda M
    • Journal Title

      Psychiatry and Clinical Neuroscience 62

      Pages: 625-625

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid-β peptides from cerebrospinal fluid to peripheral blood2008

    • Author(s)
      Jiang, J., Okochi, M., Tagami, S., Nishitomi, K., Yanagida, K., Nakayama, T., Tatsumi, S. -I., Mori, K., Takeda, M.
    • Journal Title

      Psychogeriatrics 8

      Pages: 188-195

    • NAID

      10027274800

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Amyloid-beta 42 generating process may have a biological re inegulatin of Notch signaling Jpn.2008

    • Author(s)
      Tagami S., Okochi M., Fukumori A., Takeda M.
    • Journal Title

      J.Neuropsychopharmacology 28

      Pages: 177-183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid- peptides from cerebrospinal fluid to peripheral blood.2008

    • Author(s)
      Jiang J., Okochi M., Tagami S., Nishitomi K., Yanagida K., Nakayama T., Tatsumi K.,Mori K., Takeda M.
    • Journal Title

      Psychogeriatrics 8

      Pages: 188-195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase.2008

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
    • Journal Title

      Neurodegenerative Diseases 5

      Pages: 160-162

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M.
    • Journal Title

      Molecular and Cellular Biology. 28

      Pages: 165-176

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Regulation of Notch signaling byd ynamic changes in the precision of S3 cleavage of Notch-1.2008

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
    • Journal Title

      Mol Cell Biol. 28(1)

      Pages: 165-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Processes of beta-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/gamma-Secretase.2008

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
    • Journal Title

      Neurodegener Dis. 5(3-4)

      Pages: 160-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation2008

    • Author(s)
      Okamoto K, Mori Y, Komoda Y, Okamoto T, Okochi M, Takeda M, Suzuki T, Moriishi K, Matsuura Y
    • Journal Title

      J Virol 82

      Pages: 8349-8361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008

    • Author(s)
      Tagami S. Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M.
    • Journal Title

      Molecular and Cellular Biology. 28

      Pages: 165-176

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008

    • Author(s)
      Tagami, S, Okochi, M, Yanagida, K, Ikuta, A, Fukumori, A, Matsumoto, N, Ishizuka-Katsura, Y Nakayama, T, Itoh, N, Jiang, J, Nishitomi, K, Kamino, K, Morihara, T, Hashimoto, R, Tanaka, T, Kudo, T, Chiba, S, Takeda, M
    • Journal Title

      Molecular and Cellular Biology. Jan 28

      Pages: 165-176

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid-β peptides from cerebrospinal fluid to peripheral blood2008

    • Author(s)
      Jiang, J., Okochi, M., Tagami, S., Nishitomi, K., Yanagida, K., Nakayama, T., Tatsumi, S.-I., Mori, K., Takeda, M
    • Journal Title

      Psychogeriatrics

      Pages: 188-195

    • NAID

      10027274800

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia2008

    • Author(s)
      Takahashi H, Iwase M, Ishii R, 0hi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, like N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M
    • Journal Title

      Neurosci Res 62

      Pages: 187-194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.2008

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
    • Journal Title

      Mol Cell Biol. 28(1)

      Pages: 165-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-12008

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
    • Journal Title

      Mol Cell Biol 28(1)

      Pages: 165-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C viruscore protein and viral propagation.2008

    • Author(s)
      Okamoto K, Mori Y, Komoda Y, Okamoto T, Okochi M, Takeda M, Suzuki T, Moriishi K, Matsuura Y.
    • Journal Title

      J Virol 82

      Pages: 8349-8361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Processes of beta-amyloid and intracellular cytoplasmic domaingeneration by presenili n/gamma-secretase2008

    • Author(s)
      Tagami, S, Okochi, M, Fukumori, A, Jiang, J, Yanagida, K, Nakayama, T, Morihara, T, Tanaka, T, Kudo, T, Takeda, M
    • Journal Title

      Neurodegenerative Diseases 5

      Pages: 160-162

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Processes of beta-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/gamma-Secretase2008

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M
    • Journal Title

      Neurodegener Dis 5(3-4)

      Pages: 160-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.2008

    • Author(s)
      Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M.
    • Journal Title

      Neurosci Res 62

      Pages: 187-194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Amyloid-beta 42 generating process may have a biologicalrole in regulation of Notch signaling intensity2008

    • Author(s)
      Tagami S., Okochi M., Fukumori A., Takeda M
    • Journal Title

      Jpn. J. Neuropsychopharmacology 28

      Pages: 177-183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] アルツハイマー病の薬物療法の実際2008

    • Author(s)
      大河内正康, 武田雅俊
    • Journal Title

      カレントテラピー 26

    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Macrophage colony stimulating factor is associated with exeretion of amyloid-peptides from cerebrospinal fluid to peripheral blood2008

    • Author(s)
      Jiang J., Okochi M., Tagami S., Nishitomi K., Yanagida K., Nakayama T., Tatsumi K., Mori K., Takeda M
    • Journal Title

      Psychogeriatrics 8

      Pages: 188-195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions-real problems and future possibilities2007

    • Author(s)
      Takeda, M, Okochi, M, Tagami, S, Tanaka, T, Kudo, T
    • Journal Title

      Int Psychogeriatr 19

      Pages: 391-400

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions--real problems and future possibilities2007

    • Author(s)
      Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T
    • Journal Title

      Int Psychogeriatr 19(3)

      Pages: 391-400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Biological markers as outcome measures for Alzheimer's disease interve ntions-real problems and future possibilities.2007

    • Author(s)
      Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T.
    • Journal Title

      Int Psychogeriatr. 19(3)

      Pages: 391-400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions-real problems and future possibilities.2007

    • Author(s)
      Takeda M, Okochi M, Tagami S. Tanaka T, Kudo T.
    • Journal Title

      Int Psychogeriatr. 19

      Pages: 391-400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions-real problems and future possibilities.2007

    • Author(s)
      Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T.
    • Journal Title

      International Psychogeriatrics 19

      Pages: 391-400

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      Biochemistry Apr 18;45(15)

      Pages: 4907-4914

    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Secretion of the Notch-1 A β-like peptide 」during Notch signaling2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. 28(12)

      Pages: 7890-8

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] セクレターゼ阻害薬2006

    • Author(s)
      福森 亮雄, 田上 真次, 大河内 正康, 武田 雅俊
    • Journal Title

      Pharma Medica Vol.24 No.7

      Pages: 4-4

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006

    • Author(s)
      Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, and Takeda M.
    • Journal Title

      Biochem Diophys Res Commun 344

      Pages: 525-530

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Development of new screening system for Alzheilzer disease,in vitro A・sink ,assay,toidentify the dissociation of soluble A・from fibrils2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura LM, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
    • Journal Title

      Neurobiology of Disease 22(3)

      Pages: 487-95

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci. 60 Suppl 1

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Secretion of the Notch-1 Abeta-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. 24

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R.
    • Journal Title

      Neurobiol Dis 22(3)

      Pages: 487-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Development of new screening system for Alzheimer disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
    • Journal Title

      Neurobiology of Disease. 3月号予定(in press)

    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      BIOCHEMISTRY 45(15)

      Pages: 4907-14

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct.2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      Biochemistry 45/15

      Pages: 4907-14

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. Epub

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      Biochemistry. Apr18;45(15)

      Pages: 4907-4914

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Ab induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway2006

    • Author(s)
      Kanayama, D, T, Kudo, Kimura, R, Tabuchi, N, FukumoriA, Morihara, T, Tagami, S, Tanii, H, Okochi, M, Kamino, K, Tanaka, T, Imaizumi, K, Tabira, T, Takeda, M
    • Journal Title

      Psychogeriatrics 6

      Pages: 100110-100110

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006

    • Author(s)
      Fukumori A, Okochi M.Tagami S.Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      BIOCHEMISTRY in press

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] 非ろテロイド性消炎薬(NSAIDs)のA」42産生阻害作用とその応用2006

    • Author(s)
      大河内 正康, 田上 真次, 武田 雅俊
    • Journal Title

      CURRENT THERAPY Vol 24, No.3

      Pages: 33-37

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain-2006

    • Author(s)
      Tanii, H, Jiang, J, Fukumori, A, Tagami, S, Okazaki, Y, Okochi, M, Takeda, M
    • Journal Title

      J Neurosci Res 84(4)

      Pages: 918-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. 281/12

      Pages: 7890-8

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Secretion of the Notch-1 Abeta-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Cliem. Mar24;281(12)Epub

      Pages: 7890-7898

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease.2006

    • Author(s)
      Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M and Takeda M.
    • Journal Title

      Psychogeriatrics SUPPL.2

    • NAID

      10025860692

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci. Apr;60

    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Inhibition of endocytosis activates alternative degradation pathway of CAPP in cultured cells2006

    • Author(s)
      Fukumori, A, Jiang, J, Tanii, H, Morihara, T, Kamino, K, Tanaka, T, Kudo, T, Itoh, N, Tagami, 5, Okochi, M, Takeda, M
    • Journal Title

      Psychogeriatrics 6

      Pages: 107-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] 非ステロイド性消炎薬(NSAIDs)のAβ42産生阻幸作用とその応用2006

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Journal Title

      CURRENT THERAPY Vol.24 No.3

      Pages: 33-37

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Inhibition of endocytosis activates alternative degradation pathway of・APP in cultured cells2006

    • Author(s)
      Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, and Takeda M
    • Journal Title

      Psychogeriatrics Sep 6

      Pages: 107-113

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem 24;281(12)

      Pages: 7890-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] The GxGD motif of presenilin contributes to catalytic function and substrate identification of γ-secretase.2006

    • Author(s)
      Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
    • Journal Title

      J Neurosci 26/14

      Pages: 3821-8

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. 3月号予定(in press)

    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006

    • Author(s)
      Nessa, BN, Tanaka, T, Kamino, K, Sadik, G, Ansar, AB, Kimura, R, Tanii, H, Okochi, M, Morihara, T, Tagami, S, Kudo, T, Takeda, M
    • Journal Title

      PsychiatryClin Neurosci 60 Suppl 1

      Pages: 27-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Toll-like receptor 3 mediated ρhyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci. 60 Suppl 1

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] 非ステロイド性消炎薬(NSAIDs)のAβ42産生阻害作用とその応用2006

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Journal Title

      CURRENT THERAPY 3月号予定(印刷中)

    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tauin human SH-SY5Y neuroblastoma cells.2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci. Apr60 Suppi 1

      Pages: 527-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Ito N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem 281-12

      Pages: 7890-7898

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006

    • Author(s)
      Fukumori A, *Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      Biochemistry 18;45(15)

      Pages: 4907-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] セクレターゼ阻害薬2006

    • Author(s)
      福森亮雄, 田上真次, 大河内正康, 武田雅俊
    • Journal Title

      Pharma Medica Vol.24 No.7

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006

    • Author(s)
      Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun. Jun 2;344(2)

    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006

    • Author(s)
      Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M, Takeda M.
    • Journal Title

      Psychogeriatrics Dec 6:(SUPPL.2)

    • NAID

      10025860692

    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      Biochemistry. 45(15)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591287
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci Suppl 1

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct2006

    • Author(s)
      Fukumori, A, Okochi, M, Tagami, S, Jiang, J, Itoh, N, Nakayama, T, Yanagida, K, Ishizuka-Katsura Y, Morihara, T, Kamino, K, Tanaka, T, Kudo, T, Tanii, H, Ikuta, A, Haass, C, Takeda, M
    • Journal Title

      Biochemistry 45(15)

      Pages: 4907-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591287
  • [Journal Article] Inhibition ofendocytosis activates alternative degradation pathway of β APP in cultured cells2006

    • Author(s)
      Akio Fukumori, Jingwei Jiang, Hisashi Tanii, Takashi Morihara, Kojin Kamino, Toshihisa Tanaka, Takashi Kudo, Naohiro Ito, Shinji Tagami, Masayasu Okochi, Masatoshi Takeda
    • Journal Title

      Psychogeiatrics 6(3)

      Pages: 107-113

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591210
  • [Journal Article] Biological markers for diagnosis of MCI and eurodegenerative dementia2006

    • Author(s)
      Takeda M, Kudo T, Tanaka T, Kamino K, Okochi M, Tagami S
    • Journal Title

      Functional and Moleculart Imaging of Strokeka dn Dementia

      Pages: 101-107

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006

    • Author(s)
      Nessa, BN, Tanaka, T, Kamino, K, Sadik, G, Ansar, AB, Kimura, R, Tanii, H, Okochi, M, Morihara, T, Tagami, S, Kudo, T, Takeda, M
    • Journal Title

      Psychiatry Clin Neurosci 60,1

      Pages: 527-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591287
  • [Journal Article] Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway.2006

    • Author(s)
      .Kanayama D, T, Kudo, Kimura R, Tabuchi N, Fukumori A, Morihara T, Tagami S, Tanii H, Okochi M, Kamino K, Tanaka T, Imaizumi K, Tabira T, and Takeda M.
    • Journal Title

      Psychogeriatrics 6

      Pages: 100-106

    • NAID

      10019375777

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells.2006

    • Author(s)
      Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, Takeda M
    • Journal Title

      Psychogeriatrics Sep 6

      Pages: 107-113

    • NAID

      10019375803

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Involvement of apoptosis and cholinergic dysfunction in ρAlzheimer's disease2006

    • Author(s)
      Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M and Takeda M.
    • Journal Title

      Psychogeriatrics Dec 6:

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006

    • Author(s)
      Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, Takeda M.
    • Journal Title

      J Neurosci Res Sep;84(4)

      Pages: 918-925

    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Ito N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. 3月予定(In press)

    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Development of new screening system for Alzheimer disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
    • Journal Title

      Neurobiology of Disease 22(3)

      Pages: 487-495

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase2006

    • Author(s)
      Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
    • Journal Title

      J Neuroscience 5(26)

      Pages: 3821-3828

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Effect of valine on the efficiency and precision a cleavage of the Notch-1 transmembrane domain2006

    • Author(s)
      Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, and Takeda M
    • Journal Title

      J Neurosci Res. Sep;84(4)

      Pages: 918-25

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway2006

    • Author(s)
      Daisuke Kanayama, Takashi Kudo, Ryo Kimura, Nobuhiko Tabuchi, Akio Fukumori, Takashi Morihara, Shinji Tagami, Hisashi Tanii, Masayasu Okochi, Kojin Kamino, Toshihisa Tanaka, Kazunori Imaizumi, Takeshi Tabira, Masatoshi Takeda
    • Journal Title

      Psychogeiatrics 6(3)

      Pages: 100-106

    • NAID

      10019375777

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591210
  • [Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006

    • Author(s)
      Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M, Takeda M.
    • Journal Title

      Psychogeriatrics. Dec6:(SUPPL.2)

    • NAID

      10025860692

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006

    • Author(s)
      Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, Takeda M
    • Journal Title

      J Neurosci Res. Sep;84(4)

      Pages: 918-925

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006

    • Author(s)
      Tagami, S, Tsujimoto, Y, Akaike, A, Takashima, A, Hasegawa, M, Ishiguro, K, Shoji, M, Ito, N, Kanemaru, K, Urakami, K, Okochi, M, Takeda, M
    • Journal Title

      Psychogeriatrics 6 : (SUPPL.2)

    • NAID

      10025860692

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M
    • Journal Title

      Psychiatry Clin Neurosci. 60 Suppl 1

    • Data Source
      KAKENHI-PROJECT-18591287
  • [Journal Article] Presenilin-Dependent γ-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct2006

    • Author(s)
      Akio Fukumori, Masayasu Okochi, Shinji Tagami, Jinwei Jiang, Naohiro Itoh, Taisuke Nakayama, Kanta Yanagida, Yoshiko Ishizuka-Katsura, Takashi Morihara, Kojin Kamino, Toshihisa Tanaka, Takashi Kudo, Hisashi Tanii, Akiko Ikuta, Chistian Haass, Masatoshi Takeda
    • Journal Title

      Biochemistry 45

      Pages: 4907-4914

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591210
  • [Journal Article] Steiner The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.2006

    • Author(s)
      Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C
    • Journal Title

      J Neurosci 5;26(14)

      Pages: 3821-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Ito N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. 281.12

      Pages: 7890-7898

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Development of new screening system for Alzheimer disease, in vitro Aβ slnk assay, to identify the dissociation of soluble Aβ from fibrils2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
    • Journal Title

      Neurobiology of Disease. Epub

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006

    • Author(s)
      Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
    • Journal Title

      Biochem Biophys Res Commun. 344

      Pages: 525-530

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17591210
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006

    • Author(s)
      Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun 344(2)

      Pages: 525-530

    • Data Source
      KAKENHI-PROJECT-18591287
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress2006

    • Author(s)
      Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
    • Journal Title

      Biochem Biophys Res Commun Jun2:344(2)

      Pages: 525-30

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
    • Journal Title

      Biochemistry 45 (15)

      Pages: 4907-4914

    • Data Source
      KAKENHI-PROJECT-18591287
  • [Journal Article] Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R.
    • Journal Title

      Neurobiol Dis. 22(3)

      Pages: 487-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci 60 Suppl

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591287
  • [Journal Article] The protease active site domain of γ-secretase contributes to substrate identification2006

    • Author(s)
      Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner HH
    • Journal Title

      J Neuroscience 3月号予定(in press)

    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.2006

    • Author(s)
      Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H.
    • Journal Title

      J Neurosci. 5

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Development of new screening system for Alzheimer disease, in vitro A・ sink assay, to identify the dissociation of soluble A・ from fibrils2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
    • Journal Title

      Neurobiol Dis 22/3

      Pages: 487-95

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] A β induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway2006

    • Author(s)
      Daisuke Kanayama, Takashi Kudo, Ryo Kimura, Nobuhiko Tabuchi, Akio Fukumori, Takashi Morihara, Shinji Tagami, Hisashi Tanii, Masayasu Okochi, Kojin Kamino, Toshihisa Tanaka, Kazunori Imaizumi, Takeshi Tabira, Masatoshi Takeda
    • Journal Title

      Psychogeiatrics 6(3)

      Pages: 100-106

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591210
  • [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      Biochemistry. 18

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] The protease active site domain of γ-secretase contributes to substrate identification2006

    • Author(s)
      Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
    • Journal Title

      J Neuroscience in press

    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Presenilin-Dependent Y-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct2006

    • Author(s)
      Akio Fukumori, Masayasu Okochi, Shinji Tagami, Jinwei Jiang, Naohiro Itoh, Taisuke Nakayama, Kanta Yanagida, Yoshiko Ishizuka-Katsura, Takashi Morihara, Kojin Kamino, Toshihisa Tanaka, Takashi Kudo, et al.
    • Journal Title

      Biochemistry 45

      Pages: 4907-4914

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17591210
  • [Journal Article] Inhibition of endocytosis activates alternative degradation pathway of /3 APP in cultured cells.2006

    • Author(s)
      Fukumori A, Jiang J ; Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S. Okochi M, Takeda M
    • Journal Title

      Psychogeriatrics.

      Pages: 107-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006

    • Author(s)
      Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Thhyama M, Tabira T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun. 2

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006

    • Author(s)
      Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, and Takeda M.
    • Journal Title

      Journal of Neuroscience Research 84

      Pages: 918-925

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmicreticulum stress2006

    • Author(s)
      Kudo, T, Okumura, M, Imaizumi, K, Araki, W, Morihara, T, Tanimukai, H, Kamagata, E, Tabuchi, N, Kimura, R, Kanayama, D, Fukumori, A, Tagami, S, Okochi, M, Kubo, M, Tanii, H, Tohyama, MTabira, T, Takeda, M
    • Journal Title

      Biochem BiophysReCommun 344(2)

      Pages: 525-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591287
  • [Journal Article] Inhibition of endocytosis activates alternative degradati on pathway of βAPP in cultured cells.2006

    • Author(s)
      Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, and Takeda M.
    • Journal Title

      Psychogeriatrics 6

      Pages: 107-113

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmis reticulum stress2006

    • Author(s)
      Kudo, T, Okumura, M, Imaizumi, K, Araki, W, Morihara, T, Tanimukai, H, Kamagata, E, Tabuchi, N, Kimura, R, Kanayama, D, Fukumiri, A, Tagami, S, Okochi, M, Kubo, M, Tanii, H, Tohyama, M, Tabira, T, Takeda, M
    • Journal Title

      Biochem Diophys Res Commun 344

      Pages: 525-530

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
    • Journal Title

      Biochemistry 45

      Pages: 5351-5358

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endoso mes is functionally distinct2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
    • Journal Title

      Biochemistry 45

      Pages: 5351-5358

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006

    • Author(s)
      Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun. 344(2)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591287
  • [Journal Article] Cleavage at S3 by Presenilin/g-secretase has a diversity.2005

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Kudo T, Takeda M.
    • Journal Title

      Dementia Japan 19

      Pages: 133-133

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] プレセニリン依存性膜内蛋白分解によるNotch-1のS3切断には多様性が存在する。2005

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Kudo T, Takeda M.
    • Journal Title

      Dementia Japan 19

      Pages: 133-133

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] The S3 cleavage site of Notch-1 by presenilin/γ-secretase has a diversity.2005

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Takeda M.
    • Journal Title

      日本神経化学雑誌 44

      Pages: 204-204

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] γセクレターゼとNotchシグナル2005

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Journal Title

      Molecular Medicine 42

      Pages: 790-798

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] The S3 cleavage site of Notch-1 by presenilin/γ-secretase has a diversity.2005

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Takeda M.
    • Journal Title

      Bulletin of the Japanese Society for Neurochemistry 44

      Pages: 204-204

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] アミロイドβタンパク質産生の異常がアルツハイマー病につなが2005

    • Author(s)
      大河内 正康
    • Journal Title

      アルツハイマー病:治療の可能性を探る2005第.19回「大学と科学」公開シンポジウム講演抄録集 単行本

      Pages: 13-13

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] The physiological meaning that BACE cleaves amyloid beta.2005

    • Author(s)
      Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Kudo T, Takeda M.
    • Journal Title

      Joint meeting of the 27th annual meeting of JSBP and the 35th annual meeting of JSNP 27

      Pages: 206-206

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] The mechanism of intracellular amyloid beta degradation2004

    • Author(s)
      Tagami, S., Okochi, M., Fukumori, A., Kimura, R., Jiang, J., Takeda, M
    • Journal Title

      9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9

      Pages: 97-97

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Biochemical separation of γ-cleavage of βAPP on the plasma membrane from that on the intracellular membrane2004

    • Author(s)
      Fukumori, A., Okochi, M., Tagami, S, Tanii, H., Kimura, R., Jiang, J., Steiner, H., Haass, C., Kudo, T., Takeda, M.
    • Journal Title

      9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9巻

      Pages: 157-157

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Possible assessment of Alzheimer's y-secretase activity by level of Aβ-like peptides2004

    • Author(s)
      Okochi M, Takeda, M.
    • Journal Title

      Psychogeriatrics 4

      Pages: 23-27

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Subcellular localization of γ-cleavage of βAPP.2004

    • Author(s)
      Fukumori, A., Okochi, M., Jiang, J., Kimura, R., Tanii, H., Kudo, T., Tagami, S., Takeda, M
    • Journal Title

      日本神経化学雑誌 47

      Pages: 20-20

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Possible assessment of Alzheimer's γ-secretase activity by level of Aβ-like peptides2004

    • Author(s)
      Okochi, M., Takeda, M.
    • Journal Title

      Psychogeriatrics 4

      Pages: 23-27

    • NAID

      10018089800

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Aβの毒性発現機構2004

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Journal Title

      Molecular Medicine 41-No.4

      Pages: 427-431

    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Aβの毒性発現機構2004

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Journal Title

      Molecular Medicine 41.No.4

      Pages: 427-431

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] The mechanism of intracellular amyloid beta degradation2004

    • Author(s)
      Tagami, S., Okochi, M., Fukumori, A., Kimura, R., Jiang, J., Takeda, M
    • Journal Title

      9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9巻

      Pages: 97-97

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Alzheimer's γ-secretase mechanism produces Amyloid-β-protein like peptides simultaneously with release of intracellular signaling fragments.2004

    • Author(s)
      Okochi.M., Fukumori, A., Satoh, Y., Aidaralieva, N., Tanii, H., Kamino, K., Tanaka, T., Kudo, T., Takeda M.
    • Journal Title

      Molecular Neurobiology of Alzheimer Disease and Related Disorders)(Karger Press)

      Pages: 31-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Journal Article] Biochemical separation of γ-cleavage of βAPP on the plasma membrane from that on the intracellular membrane2004

    • Author(s)
      Fukumori, A., Okochi, M., Tagami, S., Tanii, H., Kimura, R., Jiang, J., Steiner, H., Haass, C., Kudo, T., Takeda, M.
    • Journal Title

      9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9

      Pages: 157-157

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591132
  • [Journal Article] Inhibition of Aβ42 production by NSAIDS

    • Author(s)
      Okochi M, Tagami S, Takeda M
    • Journal Title

      CURRENT THERAPY 24(3)

      Pages: 33-37

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Biological markers for diagnosis of MCI and eurodegenerative dementia

    • Author(s)
      Takeda M, Kudo T, TanakaT, Karnino K, Okochi M, Tagami S
    • Journal Title

      Functional and Moleculart Imaging of Strokeka dn Dementia

      Pages: 101-107

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease

    • Author(s)
      Tagami S, Tsujimoto Y, Akaike A, TakashimaA, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K Okochi M Takeda M.
    • Journal Title

      Psychogeriatrics. 6

    • NAID

      10025860692

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain

    • Author(s)
      Tanii H, Jiang J, Fukumori A, Tagami S. Okazaki Y, Okochi M, Takeda M
    • Journal Title

      J Neurosci Res. 84(4)

      Pages: 918-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390318
  • [Patent] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010

    • Inventor(s)
      大河内正康, 田上真次, 武田雅俊, 西冨晃平
    • Industrial Property Rights Holder
      大河内正康, 田上真次, 武田雅俊, 西冨晃平
    • Filing Date
      2010-10-18
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Patent] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010

    • Inventor(s)
      大河内正康、田上真次、武田雅俊、西冨晃平
    • Industrial Property Rights Holder
      大河内正康、田上真次、武田雅俊、西冨晃平
    • Filing Date
      2010-10-18
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Patent] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010

    • Inventor(s)
      大河内正康、田上真次、武田雅俊、西冨晃平
    • Industrial Property Rights Holder
      大河内正康、田上真次、武田雅俊、西冨晃平
    • Filing Date
      2010-10-18
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Patent] セル・フリー・Notch切断分析方法および薬剤スクリーニング方法2004

    • Inventor(s)
      大河内正康, 武田雅俊
    • Industrial Property Rights Holder
      大阪TLO
    • Filing Date
      2004-11-10
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Patent] 特許出願(セル・フリー・Notch切断分析方法および薬剤スクリーニング方法)2004

    • Inventor(s)
      大河内正康, 武田雅俊
    • Industrial Property Rights Holder
      大河内正康, 武田雅俊, 大阪TLO
    • Filing Date
      2004-11-10
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591135
  • [Presentation] A brain-derived Aβ42 surrogate marker in peripheral blood2016

    • Author(s)
      Shinji Tagami, Kanta Yanagida, Takeshi Tomonaga, Takeshi Ikeuchi, Masaaki Waragai, Masatoshi Takeda, Manabu Ikeda, Masayasu Okochi
    • Organizer
      Neuroscience meeting 2016
    • Place of Presentation
      San Diego USA
    • Year and Date
      2016-11-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] ヒト血漿中に存在するAβペプチドのサロゲートマーカーAPL1βのLC-MS/MSによる測定2015

    • Author(s)
      児玉高志、大河内正康、田上真次、柳田寛太、森原剛史、田中稔久、工藤喬、朝長毅、武田雅俊
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      リンクステーション青森
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-25461766
  • [Presentation] CRISP/CAS9法によるPresenilin1/2ダブルノックアウト細胞の作製2015

    • Author(s)
      柳田 寛太 田上 真次   児玉 高志  岡本 徹 松浦 善治 武田 雅俊 大河内 正康
    • Organizer
      第34回 日本認知症学会 学術総会
    • Place of Presentation
      リンクステーションホール青森
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] ヒト血漿中に存在するAβペプチドのサロゲートマーカーAPL1βのLC/MS/MSによる測定2015

    • Author(s)
      児玉 高志 大河内 正康  田上 真次 柳田 寛太 森原 剛史  田中 稔久 朝長 毅 工藤 喬 武田 雅俊
    • Organizer
      第34回 日本認知症学会 学術総会
    • Place of Presentation
      リンクステーションホール青森
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] Development of Abeta42 surrogate marker in peripheral blood2015

    • Author(s)
      Shinji Tagami Shozo Sano Kanta Yanagida Takashi Kodama Naoki Mizuta Takeshi Tomonaga Masatoshi Takeda Masayasu Okochi
    • Organizer
      12th World Congress Of Biological Psychiatry
    • Place of Presentation
      Greece, Athens
    • Year and Date
      2015-06-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] 家族性アルツハイマー病の脳内でAβ42産生は亢進しているか?2015

    • Author(s)
      田上 真次 柳田 寛太  児玉 高志  新井 哲明 池内 健 武田 雅俊 大河内 正康
    • Organizer
      第34回 日本認知症学会 学術総会
    • Place of Presentation
      リンクステーションホール青森
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] アミロイドベータ産生機構解析のための細胞内ペプチドの測定2014

    • Author(s)
      児玉高志、大河内正康、田上真次、柳田寛太、高見真子、井原康夫、武田雅俊
    • Organizer
      第25回日本老年医学会近畿地方会
    • Place of Presentation
      和歌山県立医科大学
    • Year and Date
      2014-10-11
    • Data Source
      KAKENHI-PROJECT-25461766
  • [Presentation] γセクレターゼの阻害と促進2014

    • Author(s)
      大河内正康
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-30
    • Data Source
      KAKENHI-PROJECT-26461745
  • [Presentation] CSF APL1β28 is a possible surrogate marker for Aβ42 production in human brains2013

    • Author(s)
      Naoki Mizuta, Masayasu Okochi, Shinji Tagami,Kanta Yanagida, Takashi Kodama,Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-06-21
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Identification and quantitative analysis of short peptides derived from amyloid-beta peptides in living cell2013

    • Author(s)
      Kodama T.S., Okochi M., Tagami S., Yanagida K., Mizuta N., Tanaka T., Morihara T., Kudo T., Takami M., Ihara Y., Takeda M.
    • Organizer
      IPA's 16th International Congress
    • Place of Presentation
      Seoul Korea, COEX
    • Year and Date
      2013-10-02
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Identification of APLP2-derived Ab-like peptides from human Cerebrospinal fluid2013

    • Author(s)
      柳田寛太、 大河内正康、田上真次、児玉高志、武田雅俊
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2013-06-27
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Regulation of presenilin/gamma-secretase function; towards intervention of Alzheimer disease in future2013

    • Author(s)
      Tagami S, Okochi M, Takeda M
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto, Japan (Symposium)
    • Year and Date
      2013-06-26
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Regulation of presenilin/gamma-secretase function; towards intervention of Alzheimer disease in future2013

    • Author(s)
      Tagami S, Okochi M, Takeda M.
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      京都国際会議場 京都
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Elucidation of the mechanism underlying the alteration of Aβ42 ratio by g-secretase modulators.2013

    • Author(s)
      Tagami S, Okochi M, Takeda M.
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, California(USA)
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Identification and quantitative analysis of APL1ß peptides in human cerebrospinal fluid (CSF)2013

    • Author(s)
      Takashi. S. Kodama, Masayasu Okochi, Sinji Tagami, Kanta Yanagida, Naoki Mizuta, Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2013-06-27
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Potential Action Mechanism of γ-Secretase Modulators2013

    • Author(s)
      Okochi M
    • Organizer
      AD/PD2013
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2013-10-06
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Determination of APL1ß Peptide Concentration in Cerebrospinal Fluid (CSF) by ELISA2013

    • Author(s)
      Takashi. S. Kodama, Masayasu Okochi, Sinji Tagami, Kanta Yanagida, Naoki Mizuta, Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
    • Organizer
      Neuro2013
    • Place of Presentation
      Kyoto, International Conference Center
    • Year and Date
      2013-06-21
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Degradation of extracellular Aβ42/43 in human brain and cultured cells2013

    • Author(s)
      Naoki Mizuta, Masayasu Okochi, Shinji Tagami, Kanta Yanagida, Takashi Kodama, Mako Takami, Yasuo Ihara, Daisuke Kanayama, Takashi Morihara, Takashi Kudo, Toshihisa Tanaka, Masatoshi Takeda
    • Organizer
      CTAD2013
    • Place of Presentation
      San Diego
    • Year and Date
      2013-11-14
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Ab42 is an intermediated stopover product of PS/g-secrease2013

    • Author(s)
      Okochi M
    • Organizer
      SFB seminor
    • Place of Presentation
      LMU, Munich
    • Invited
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Elucidation of the mechanism underlying the alteration of Aβ42 ratio by g-secretase modulators2013

    • Author(s)
      Tagami S, Okochi M, Takeda M
    • Organizer
      Neuroscience 2013 Nanosymposium
    • Place of Presentation
      San Diego, California
    • Year and Date
      2013-11-11
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] APL1β28, a new candidate biomarker for Alzheimer disease2013

    • Author(s)
      Naoki Mizuta, Masayasu Okochi, Shinji Tagami, Kanta Yanagida, Takashi Kodama, Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2013-06-24
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Chracterization of brain APL2β, an Aβ-like peptide produced from APLP22012

    • Author(s)
      Masayasu Okochi, Kanta Yanagida, Shinji Tagami, Takashi Kodama, Shozo Sano,Takeshi Tomonaga, Takaomi C.Saido, Masatoshi Takeda
    • Organizer
      Alzheimer's Association International Conference 2012
    • Place of Presentation
      Vancouver Convention & Exhibition Centre, Vancouver Canada
    • Year and Date
      2012-07-18
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際2012

    • Author(s)
      大河内 正康 田上 真次 柳田 寛太児玉 高志 武田 雅俊
    • Organizer
      第31回日本認知症学会学術集会 トピックス徹底討論「抗 Ab 療法の最新現状と徹底討論」
    • Place of Presentation
      つくば国際会議場、第4 会場 2F 中ホール
    • Year and Date
      2012-10-28
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] APL2βの産生メカニズムの解析(1)APLP2はプレセニリン1と2で異なる切断を受ける2012

    • Author(s)
      柳田寛太, 大河内正康, 田上真次, 児玉高志, 森原剛史, 田中稔久, 工藤喬, 武田雅俊
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2012-10-27
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] アルツハイマー病のバイオマーカーと新しい診断基準2012

    • Author(s)
      大河内正康
    • Organizer
      第19回近畿老年期認知症研究会
    • Place of Presentation
      リーガロイヤルNCB、大阪
    • Invited
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] ヒト脳脊髄液中APL1βペプチドの高感度定量2012

    • Author(s)
      児玉高志, 大河内正康, 田上真次, 柳田寛太, 森原剛史, 田中稔久, 工藤喬, 朝長毅, 武田雅俊
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2012-10-26
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際2012

    • Author(s)
      大河内正康, 田上真次, 柳田寛太, 児玉高志, 武田雅俊
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2012-10-28
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] 「γセクレターゼ修飾薬(GSM)のアルツハイマー予防薬としての理論と実際」2012

    • Author(s)
      大河内正康
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Chracterization of brain APL2β, an Aβ-like peptide produced from APLP22012

    • Author(s)
      Masayasu Okochi, Kanta Yanagida, Shinji Tagami, Takashi Kodama, Shozo Sano,Takeshi Tomonaga, Takaomi C.Saido, Masatoshi Takeda
    • Organizer
      Alzheimer's Association International Conference 2012
    • Place of Presentation
      Vancouver Convention & Exhibition Centre
    • Year and Date
      2012-06-20
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] アルツハイマー病発症前診断バイオマーカーの開発2012

    • Author(s)
      大河内正康
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場
    • Invited
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] ラフトのγセクレターゼによるAPP膜内段階的切断機構2012

    • Author(s)
      松村展敬, 高見真子, 田上真次, 大河内正康, 井原康夫, 森島真帆
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2012-10-26
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] APL2βの産生メカニズムの解析(2)APLP2はプレセニリン1と2で異なる切断を受ける2012

    • Author(s)
      柳田寛太, 大河内正康, 田上真次, 児玉高志, 森原剛史, 田中稔久, 工藤喬, 武田雅俊
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2012-10-27
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] アルツハイマー病発症前診断バイオマーカーの開発 脳プロ課題 F ・アミロイドβ42 産生の上流機構の解析(武田班)2012

    • Author(s)
      大河内正康 田上 真次 朝長毅 武田雅俊
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      会場:E 会場(神戸国際会議場502)
    • Year and Date
      2012-09-30
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Biochemistry of "Ab-like Peptide", a novel type of peptide family2011

    • Author(s)
      Masayasu Okochi
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-07-24
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] S15-4 認知症バイオマーカーと次世代認知症治療戦略2011

    • Author(s)
      大河内正康
    • Organizer
      第21回日本臨床精神神経薬理学会, 第41回日本神経精神薬理学会合同年会
    • Place of Presentation
      第2 会場(コンコード B)シンポジウム 15 認知症の病態理解から診断・治療法へ
    • Year and Date
      2011-10-27
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Comparison of pretreatment methods for SISCAPA-SRM quantitation of Alzheimer disease biomaker peptide APL1beta in plasma2011

    • Author(s)
      Shozo Sano, Shinji Tagami, Masayasu Okochi, Kumiko Yoshizawa-Kumagaye, Masahiko Tsunemi, Yoshio Kodera and Takeshi Tomonaga
    • Organizer
      日本ヒトプロテオーム機構第9回大会
    • Place of Presentation
      新潟市朱鷺メッセ
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] βAPPファミリー蛋白は脳内では主にBACEによってsheddingを受けるが培養細胞に過剰発現させるとα-セクレターゼによる切断が増加する2011

    • Author(s)
      柳田寛太, 大河内正康, 田上真次, 児玉高志, 森原剛史, 田中稔久, 工藤喬, 武田雅俊
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      タワーホール船堀
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Absolute quantitation of plasma biomarker peptides for Alzheimer disease at pM level using SRM coupled with stable isotope standards and capture by anti-peptide antibodies2011

    • Author(s)
      Shio Watanabe, Shinji Tagami, Shozo Sano, Kumiko Yoshizawa-Kumagaye, Masahiko Tsunemi, Masayasu Okochi and Takeshi Tomonaga
    • Organizer
      日本ヒトプロテオーム機構第9回大会
    • Place of Presentation
      新潟市朱鷺メッセ
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] The 28-amino Acid Form of an APLP1-derived Ab-like Peptide is a Surrogate Marker for Ab422011

    • Author(s)
      Masayasu Okochi
    • Organizer
      AAICAD2011, July 16-21, 2011
    • Place of Presentation
      Paris Porte de Versailles, Convention and Exhibition Center Paris, France(招待講演)
    • Year and Date
      2011-07-20
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Session Title: A Return to the Basics- Molecular Decoding of the Alzheimer's Disease Pathogenesis""アルツハイマー病治療薬γセクレターゼ・モジュレーターの理論とその将来的優位性について2011

    • Author(s)
      大河内正康
    • Organizer
      第33回生物学的精神医学会
    • Place of Presentation
      シンポジウム2・アルツハイマー病治療薬の新たな展開 ホテルグランパシフィック LE DAIBA・パレロワイヤル B
    • Year and Date
      2011-05-21
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] The 28-amino Acid Form of an APLP1-derived Ab-like Peptide is a Surrogate Marker for Ab422011

    • Author(s)
      Masayasu Okochi
    • Organizer
      AAICAD2011
    • Place of Presentation
      Paris Porte de Versailles, Convention and Exhibition Center, France
    • Year and Date
      2011-07-21
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Decrease in major amyloid beta species may trigger amyloidogenesis in vivo.2011

    • Author(s)
      Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi Takashi Morihara, Hitoshi Tanimukai, Hiroaki Kazui, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda
    • Organizer
      10th World Congress of Biological Psychiatry
    • Place of Presentation
      Prague, Czech Republic
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] "βAPPファミリー蛋白は脳内では主にBACEによってsheddingを受けるが培養細胞に過剰発現させるとα-セクレターゼによる切断が増加する2011

    • Author(s)
      柳田 寛太 大河内 正康 田上 真次 児玉 高志 森原 剛史 田中 稔久 工藤 喬 武田 雅俊
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      タワーホール船堀
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] "Abeta蓄積修飾遺伝子KLC1 splicing variantの同定(1) APPTgマウスを用いた網羅的解析2011

    • Author(s)
      林 紀行 横小路 美貴子 森原 剛史 田上 真次 大河内 正康 田中 稔久 工藤 喬 武田 雅俊
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      タワーホール船堀
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Immuno-SRM/MRMを用いた新規アルツハイマー病血漿マーカーペプチドAPL1βの絶対定量法の確立と臨床応用2011

    • Author(s)
      渡邊史生, 田上真次, 佐野聖, 三熊谷久美子, 常見雅彦, 大河内正康, 朝長毅
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] BACEとγセクレターゼによって産生される脳内Abeta様ペプチドを末梢血中で検出・同定する2011

    • Author(s)
      田上真次, 大河内正康, 柳田寛太, 児玉高志, 池内健, 佐野聖, 三渡邊史, 生数井裕光, 森原剛史, 谷向仁, 田中稔久, 工藤喬, 朝長毅, 武田雅俊
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      タワーホール船堀
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Decrease in major amyloid beta species may trigger amyloidogenesis in vivo2011

    • Author(s)
      Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi Takashi Morihara, Hitoshi Tanimukai, Hiroaki Kazui, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda
    • Organizer
      10th World Congress of Biological Psychiatry, Prague
    • Place of Presentation
      Czech Republic
    • Year and Date
      2011-05-30
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Comparison of pretreatment methods for SISCAPA-SRM quantitation of Alzheimer disease biomaker peptide APL1beta in plasma.2011

    • Author(s)
      Shozo Sano, Shinji Tagami, Masayasu Okochi, Kumiko Yoshizawa-Kumagaye, Masahiko Tsunemi, Yoshio Kodera and Takeshi Tomonaga
    • Organizer
      日本ヒトプロテオーム機構第9回大会
    • Place of Presentation
      新潟市朱鷺メッセ
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] New aspects of pathophysiology and therapeutic/diagnostic strategy of dementia The ratio of CSF APL1beta28, a surrogate marker for Abeta422010

    • Author(s)
      Masa Okochi
    • Organizer
      increases before onset of sporadic Alzheimer diseaseICAD2010
    • Place of Presentation
      Hawaii Convention Center,Honolulu, Hawaii. Oral session
    • Year and Date
      2010-07-14
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析 amyloid beta42のサロゲートマーカー、APL1beta 28について2010

    • Author(s)
      田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
    • Organizer
      日本ヒトプロテオーム機構第8回大会
    • Place of Presentation
      東京ベイホテル東急
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients2010

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
    • Organizer
      第53回日本神経化学会(神戸)大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] The Rato of Cs Apl1eta28, a Surrogate Marker for Abeta42, Increases Beore Onset of Sporadic Alzheimer'S Disease, Alzheimer's Assoiation.2010

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takeda M.
    • Organizer
      Internional Conference on Alzheimer's Disease 2010
    • Place of Presentation
      Honolulu Hawaii U.S.A Tagami
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] アルツハイマー病Aβとは何か?Aβとよく似た生理ペプチドの発見とその応用についてPractical use of novel physiological peptides produced by beta-and gamma-secretases.2010

    • Author(s)
      大河内正康
    • Organizer
      つくばブレインサイエンスセミナー(TBSA)講演会
    • Place of Presentation
      筑波大学付属病院講堂
    • Year and Date
      2010-09-21
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Levels of the surrogate marker for Abeta42(i.e., APL1beta)in CSF of sporadic Alzheimer disease patients increase before the onset of its clinical symptoms2010

    • Author(s)
      Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Takeda M
    • Organizer
      第53回日本神経化学会(神戸)大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients2010

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
    • Organizer
      第53回日本神経化学会(神戸)大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析amyloid beta42のサロゲートマーカー2010

    • Author(s)
      田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
    • Organizer
      APL1beta 28について日本ヒトプロテオーム機構第8回大会
    • Place of Presentation
      東京ボイホテル東急
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Abeta全体を産生する仕組みはアルツハイマー病で加速されているか?-患者CSFを用いた解析2010

    • Author(s)
      大河内正康, 田上真次, 柳田寛太, 池内健, 秋山治彦, 徳田隆彦, 武田雅俊
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋市ウインク愛知
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients.2010

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
    • Organizer
      第53回日本神経化学会(神戸)大会Neuro2010
    • Place of Presentation
      神戸コンボンションセンター
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析 amyloid beta42のサロゲートマーカー、APL1beta28について2010

    • Author(s)
      田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
    • Organizer
      日本ヒトプロテオーム機構第8回大会
    • Place of Presentation
      東京ベイホテル東急
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Determination of Amino acid sequences of several thousand peptides in human cerebrospinal fluid2010

    • Author(s)
      Kodama S, Okochi M, Tagami S, Yanagida K, Nakayama T, Tatsumi S, Mori K, Takeda M
    • Organizer
      第53回日本神経化学会(神戸)大会Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease2010

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takeda M
    • Organizer
      Alzheimer's Association International Conference o Alzheimer's Disease 2010
    • Place of Presentation
      Honolulu Hawaii U.S.A
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease2010

    • Author(s)
      Okochi M, Tagami S, Yanagida K, Takeda M
    • Organizer
      Alzheimer's Association International Conference o Alzheimer's Disease 2010
    • Place of Presentation
      Honolulu Hawaii U.S.A
    • Year and Date
      2010-07-15
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] Aβ様ペプチドの分泌から見えること-Aβ産生過程の発症への関与の可能性2010

    • Author(s)
      大河内正康
    • Organizer
      第29回日本認知症学会・シンポジウム 7
    • Place of Presentation
      名古屋ウインク愛知・第2 会場
    • Year and Date
      2010-11-06
    • Data Source
      KAKENHI-PROJECT-22591284
  • [Presentation] 末梢血中のamyloid beta42のサロゲートマーカー開発について2010

    • Author(s)
      田上真次, 大河内正康, 児玉高志, 柳田寛太, 佐野聖三, 朝長毅, 武田雅俊
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋市ウインク愛知
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] 病的に低下した Notch シグナルを是正する新たな方法の開発について2009

    • Author(s)
      田上真次, 大河内正康
    • Organizer
      第4回 Notch 研究会
    • Place of Presentation
      国立遺伝学研究所講堂
    • Year and Date
      2009-07-30
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Overproduction of Aβ42 may not occur even in brain of PS1 familial AD patients in which tremendous amounts of Aβ42 accumulate in cotton wool plaques.2009

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      仙台、東北大学百周年記念会館
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Analysis of an Aβ-like peptide in human CSF to address how the cleavage precision of presenilin/γ-secase iltered in PS1 familiaAD pats.2009

    • Author(s)
      S, Okochi M, Takeda M.
    • Organizer
      InternationalConferenc on Alzheimer's Disease (ICAD)
    • Place of Presentation
      Messe Wien Exhibition and Congress Center Vienna, Austria
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] 病的に低下したNotchシグナルを是正する新たな方法の開発について2009

    • Author(s)
      田上真次, 大河内正康
    • Organizer
      第4回Notch研究会
    • Place of Presentation
      国立遺伝学研究所講堂
    • Year and Date
      2009-07-30
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] 家族性アルツハイマー病の発症機序において、脳内アミロイドβ42の産生増大は本当に起こっているか?2009

    • Author(s)
      田上真次, 大河内正康, 柳田寛太, 中山泰亮, 児玉高志, 辰巳真一, 森康治, 武田雅俊
    • Organizer
      第16回未病システム学会総会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2009-10-31
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Analysis of an Aβ-like peptide in human CSF to address how the cleavage precision of presenilin/γ-secretase is altered in PS1 familial AD patients2009

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Organizer
      International Conference on Alzheimer's Disease (ICAD)
    • Place of Presentation
      Messe Wien Exhibition and Congress Center Vienna, Austria
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Overproduction of Aβ42 may not occur even in brain of PS1 familial AD patients in which tremendous amounts of Aβ42 accumulate in cotton wool plaques. -Aβ40 is "good" and Aβ42 is "bad"?2009

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      仙台, 東北大学百周年記念会館
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Characterization of APLP1-derived Abeta-like peptide in brains of Alzheimer disease patients2008

    • Author(s)
      Okochi, M
    • Organizer
      ICAD2008
    • Year and Date
      2008-07-24
    • Data Source
      KAKENHI-PROJECT-19591352
  • [Presentation] Changes in the cleavage precision of presenilin/r-secretase regulate Notch signaling intensity2008

    • Author(s)
      Tagami, s., Okochi, M., Takeda, M
    • Organizer
      The llth International Conference on Alzheimer's disease and Related Disorders
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2008-07-30
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Changes in the cleavage preision of presenilin/γ-secretase regulate Notch signalingtensity.2008

    • Author(s)
      Tagami, S., Okochi, M., Takeda, M.
    • Organizer
      The 11th International Conference on Alzheimer's disease and Related Disorders
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Year and Date
      2008-07-30
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] 「アルツハイマー病の病原性物質であるAβ42」を産生する仕組みには「細胞の分化に必須のNotchシグナル強度」を調節する生理作用がある-Aβ42産生抑制薬の開発時に予想される問題点とその解決法の模索2008

    • Author(s)
      田上真次 大河内正康武田雅俊
    • Organizer
      第51回日本神経化学大会 シンポジウム8アルツハイマー病の神経化学
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-12
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] アルツハイマー病の病原性物質であるAβ42」を産生する仕組みには「細胞の分化に必須のNotchシグナル強度」を調節する生理作用がある2008

    • Author(s)
      田上真次, 大河内正康, 武田雅俊
    • Organizer
      第51回日本神経化学大会シンポジウム8アルツハイマー病の神経化学
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-12
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Relation between presenilin/r-secretase modulators and Notchsignaling intensity2008

    • Author(s)
      Tagami s, Okochi M, Yanagida K, Nakayama T, Kodama T, Tatsumi s, Jiang J, Mori KSakaguchi G, KatoA, Hasegawa H, NishimuraM, Takeda M
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      群馬県前橋テルサ
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] プレセニリンフセクレターゼ修飾薬の生理活性について2008

    • Author(s)
      田上真次 大河内正康武田雅俊
    • Organizer
      第51回日本神経化学大会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-09-12
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Relation between preseniln/γ -secretase modulators and Notch signaling intensity.2008

    • Author(s)
      Tagami S, Okochi M, Yanagida K, Nakayama T, Kodama T, Tatsumi S, Jiang J, Mori KSakaguchi G, Kato A, Hasegawa H, Nishimra M, Takeda M.
    • Organizer
      第27回日本認知症学会
    • Place of Presentation
      群馬県前橋テルサ
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Notch signaling can be up-regulated through modification ofpresenilin/r-secretase-mediated S3 cleavage2008

    • Author(s)
      Tagami, s., Okochi, M., Takeda, M
    • Organizer
      The 31th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      東京国際会議場
    • Year and Date
      2008-07-10
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Notch signaling can be up-regulated through modification of presenilin/γ-secretase-mediated S3 cleavage.2008

    • Author(s)
      Tagami, S., Okochi, M., Takeda, M.
    • Organizer
      The 31th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      東京国際会議場
    • Year and Date
      2008-07-30
    • Data Source
      KAKENHI-PROJECT-20591405
  • [Presentation] Changes in a precision of S3 cleavage by presenilin/γ-secretase regulate Notch signaling.2007

    • Author(s)
      Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
    • Organizer
      The 13th Congress of International Psychogeriatric Association
    • Place of Presentation
      大阪国際会議場
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Changes in a precision of S3 cleavage by presenilin/y-secretase regulate Notch signaling2007

    • Author(s)
      Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
    • Organizer
      The 13th Congress of International Psychogeriatric Association
    • Place of Presentation
      Osaka International Congress Hall
    • Year and Date
      2007-10-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Dynamic regulation of Notch signaling by presenilin/y-secretase2007

    • Author(s)
      Tagami, S., Okochi, M., Takeda, M
    • Organizer
      The 13th Congress of International Psychogeriatric Association
    • Place of Presentation
      Osaka International Congress Hall
    • Year and Date
      2007-10-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Dynamic regulation of Notch signaling by presenilin/γ-secretase2007

    • Author(s)
      Tagami, S., Okochi, M., and Takeda M.
    • Organizer
      The 13th Congress of International Psychogeriatric Association
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-10-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Enhancement of Abeta degradation by BACE1.2007

    • Author(s)
      Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
    • Organizer
      The 13th Congress of International Psychogeriatric Association
    • Place of Presentation
      大阪国際会議場
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Changes in a precision of S3 cleavage by presenilin/γ-secretaseregulate Notch signaling.2007

    • Author(s)
      Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
    • Organizer
      The 13th Congress of International Psychogeriatric Association
    • Place of Presentation
      大阪国際会議場
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Regulation of Notch signaling by a novel S3 cleavage diversity2007

    • Author(s)
      Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
    • Organizer
      29th JSBP
    • Place of Presentation
      Sapporo convention center
    • Year and Date
      2007-07-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12007

    • Author(s)
      Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
    • Organizer
      37th Neoroscience Meeting
    • Place of Presentation
      San Diego Convention Center Room 28E
    • Year and Date
      2007-11-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-1.2007

    • Author(s)
      Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
    • Organizer
      37th Neoroscience Meeting
    • Place of Presentation
      San Diego Convention Center Room 28E
    • Year and Date
      2007-11-05
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Enhancement ofAbeta degradation by BACE12007

    • Author(s)
      Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
    • Organizer
      The 13th Congress of International Psychogeriatric Association
    • Place of Presentation
      Osaka International Congress Hall
    • Year and Date
      2007-10-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Regulation of Notch signaling by a novel S3 cleavage diversity2007

    • Author(s)
      田上真次 大河内正康 柳田寛太 生田亜希子 福森亮雄 森康治 姜 経緯 西冨晃平 小栗崇史 中山泰亮 武田雅俊
    • Organizer
      第29回日本生物学的精神医学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2007-07-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Comparison of S3 cleavage of Notch-1 withy-cleavage of BAPP by presenilin/y-secretase2006

    • Author(s)
      Tagami, S., Okochi, M., Fukumori, A., Takeda, M
    • Organizer
      The 10th International Conference on Alzheimer's disease and Related Disorders
    • Place of Presentation
      IFEMA Feria de Madrid, Spain
    • Year and Date
      2006-07-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Regulation of Notch signaling by presenilin/□-secretase2006

    • Author(s)
      田上真次 大河内正康 福森亮雄 姜 経緯 森康治 中山泰亮 生田亜希子 桂芳子 小栗崇史 西冨晃平 伊藤尚弘 柳田寛太 武田雅俊
    • Organizer
      第49回日本神経化学会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2006-09-14
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Effects of multiple factors including y-secretase modifiers on the precision of Presenilin-dependent intramambranous proteolysis2006

    • Author(s)
      Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
    • Organizer
      25th JSDR
    • Place of Presentation
      Nagoya convention center
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Regulation of Notch signaling by presenilin/y-secretase2006

    • Author(s)
      Tagami, S., Okochi, M., Fukumori, A., Takeda, M
    • Organizer
      49th JNC
    • Place of Presentation
      Nagoya convention center
    • Year and Date
      2006-09-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Comparison of S3 cleavage of Notch-1 with ε-cleavage of βAPP by presenilin/γ-secretase2006

    • Author(s)
      Shinji Tagami, Masayasu Okochi, Akio Fukumori, and Masatoshi Takeda
    • Organizer
      The 10th International Conference on Alzheimer's disease and Related Disorders
    • Place of Presentation
      IFEMA Feria de Madrid, Spain
    • Year and Date
      2006-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] Effects of multiple factors including γ-secretase modifiers on the precision of Presenilin-dependent intramambranous proteolysis.2006

    • Author(s)
      田上真次 大河内正康 福森亮雄 姜 経緯 森康治 中山泰亮 生田亜希子 桂芳子 小栗崇史 西冨晃平 伊藤尚弘 柳田寛太 武田雅俊
    • Organizer
      第25回日本認知症学会大会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2006-10-06
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591285
  • [Presentation] APL2βの産生メカニズムの解析(1)APLP2はプレセニリン1と2で異なる切断を受ける

    • Author(s)
      柳田 寛太 大河内 正康 田上 真次 児玉 高志 森原 剛史 田中 稔久 工藤 喬 武田 雅俊
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] Identification and quantitative analysis of short peptides derived from amyloid-beta peptides in living cell

    • Author(s)
      Kodama T.S., Okochi M., Tagami S., Yanagida K., Mizuta N., Tanaka T., Morihara T., Kudo T., Takami M., Ihara Y., Takeda M.
    • Organizer
      IPA’s 16th International Congress
    • Place of Presentation
      COEX( Seoul Korea)
    • Data Source
      KAKENHI-PROJECT-25461766
  • [Presentation] 細胞内に存在するAbeta由来のオリゴペプチドのLC-MS/MSによる測定

    • Author(s)
      児玉高志、大河内正康、田上真次、柳田寛太、水田直樹、高見真子、井原康夫、武田雅俊
    • Organizer
      第33回 日本認知症学会学術集会
    • Place of Presentation
      パシフィコ横浜 会議センター
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-25461766
  • [Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際

    • Author(s)
      大河内 正康 田上 真次 柳田 寛太 児玉 高志 武田 雅俊
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] APL2βの産生メカニズムの解析(2)APLP2はプレセニリン1と2で異なる切断を受ける

    • Author(s)
      柳田 寛太 大河内 正康 田上 真次 児玉 高志 森原 剛史 田中 稔久 工藤 喬 武田 雅俊
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] 脳脊髄液中のAβ分解産物の同定

    • Author(s)
      水田 直樹 大河内 正康  田上 真次 柳田 寛太 児玉 高志  佐野 聖三 朝長 毅 森原 剛史  田中 稔久 武田 雅俊
    • Organizer
      第33回 日本認知症学会 学術総会
    • Place of Presentation
      パシフィコ横浜 会議センター
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] iPS由来ヒト大脳皮質神経細胞のAβ産生に関連する性質

    • Author(s)
      大河内 正康 柳田 寛太 大山 洋 児玉 高志 高見 真子 井原 康夫阪口 岳 田上 真次 武田 雅俊
    • Organizer
      第33回 日本認知症学会 学術総会
    • Place of Presentation
      パシフィコ横浜 会議センター
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] ヒト脳脊髄液中APL1βペプチドの高感度定量

    • Author(s)
      児玉 高志 大河内 正康 田上 真次 柳田 寛太 森原 剛史 田中 稔久 工藤 喬 朝長 毅 武田 雅俊
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] ラフトのγセクレターゼによるAPP膜内段階的切断機構

    • Author(s)
      松村 展敬 高見 真子 田上 真次 大河内 正康 井原 康夫 森島 真帆
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Data Source
      KAKENHI-PROJECT-23591703
  • [Presentation] 細胞内に存在するAβ由来のオリゴペプチドのLC-MS/MSによる測定

    • Author(s)
      児玉 高志 大河内 正康  田上 真次 柳田 寛太 水田 直樹  高見 真子 井原 康夫 武田 雅俊
    • Organizer
      第33回 日本認知症学会 学術総会
    • Place of Presentation
      パシフィコ横浜 会議センター
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] 末梢血中のAβ42サロゲートマーカー、APL1b28の開発状況について

    • Author(s)
      田上 真次 大河内 正康  佐野 聖三 柳田 寛太 児玉 高志 水田 直樹  朝長 毅 武田 雅俊
    • Organizer
      第33回 日本認知症学会 学術総会
    • Place of Presentation
      パシフィコ横浜 会議センター
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] γセクレターゼの阻害と促進

    • Author(s)
      大河内 正康 田上 真次  柳田 寛太 武田 雅俊
    • Organizer
      第33回 日本認知症学会 学術総会
    • Place of Presentation
      パシフィコ横浜 会議センター
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] γ-secretase modulatorはAD由来のiPS細胞にも効果がある

    • Author(s)
      柳田 寛太 大山 洋 大河内 正康  田上 真次  児玉 高志 水田 直樹  阪口 岳 武田 雅俊
    • Organizer
      第33回 日本認知症学会 学術総会
    • Place of Presentation
      パシフィコ横浜 会議センター
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-26461746
  • [Presentation] Levels of an amyloid beta42 surrogate marker in CSF of familial Alzheimer disease patients

    • Author(s)
      Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi Takashi Morihara, Tetsuaki Arai, Toshihisa Tanaka, Masatoshi Takeda
    • Organizer
      XVI World Congress of Psychiatr
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2014-09-14 – 2014-09-18
    • Data Source
      KAKENHI-PROJECT-26461746
  • 1.  TAGAMI Shinji (40362735)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 273 results
  • 2.  TAKEDA Masatoshi (00179649)
    # of Collaborated Projects: 14 results
    # of Collaborated Products: 267 results
  • 3.  TANAKA Toshihisa (10294068)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 27 results
  • 4.  KUDO Takashi (10273632)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 32 results
  • 5.  KAMINO Kouzin (40307955)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 16 results
  • 6.  YANAGIDA Kanta (70467596)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 7.  KODAMA Takashi (30512131)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 8.  MORIHARA Takashi (90403196)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 25 results
  • 9.  谷井 久志 (40346200)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  TAKEDA Junko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  KAZUI Hiroaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  池田 学
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  池田 和博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  鈴木 利治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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