MASAYASU Okochi 大河内正康

Researcher Number	90335357
Other IDs
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Affiliation (based on the past Project Information) *help	2016 – 2019: 大阪大学, 医学系研究科, 講師 2015: 大阪大学, 医学研究科, 講師 2011 – 2015: 大阪大学, 医学(系)研究科(研究院), 講師 2013: 大阪大学, 大学院医学系研究科, 講師 2010 – 2012: 大阪大学, 医学系研究科, 講師 … More 2010: 大阪大学, 大学院・医学系研究科, 講師 2007 – 2009: Osaka University, Graduate School of Medicine, Assistant Professor 2007: 大阪大学, 医学系・研究科, 助教 2002 – 2006: 大阪大学, 医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Psychiatric science / Biological Sciences / Psychiatric science Except Principal Investigator Psychiatric science / Psychiatric science
Keywords	Principal Investigator アルツハイマー病 / アミロイドβ蛋白 / γセクレターゼ / プレセニリン / Notchシグナル伝達 / Notch-1 / 精神神経科学 / 老人斑 / γ切断 / βアミロイド蛋白前駆体 … More / 患者細胞 / アミロイドβペプチド / ゲノム編集技術 / iPS技術 / γ-cleavage / βAPP / Amyloid-β peptide / Notch signaling / γ-secretase / presenilin / Alzheimer's disease / 膜内タンパク分解 / Aβ / 酵素と基質の解離 / 膜内蛋白分解 / 超微量物質定量 / バイオマーカー / プロテオームリサーチ / LC/MS/MS / 精神疾患 / 神経変性疾患 / アミノ酸配列決定 / ペプチド / 質量分析解析 / 精神神経疾 / 疾患関連物質探索 / 質量分析 / 脳脊髄液 / 質量分析法 / 精神神経疾患 / サロゲートマーカー / 不溶性蛋白 / APLP1 / Notch1 / Notch-1-β peptide / CTF_γ / CTFγ / ATP依存的蛋白分解 / CD44 Aβ-like peptide / CD44 / Notch-1 Aβ-like peptide … More Except Principal Investigator アルツハイマー病 / Alzheimer disease / BACE / アポトーシス / アミロイドβ / γセクレターゼ / cell-free BACE assay / Notch-1 / プレセニリン / gamma secretase / NSAID / Presenilin / ガンマセクレターゼ / アミロイドベータの分解 / endoplasmic reticulum stress / APP / 分子シャペロン / 神経細胞死 / 神経原線維変化 / タウオパチー / タウ蛋白 / Z-DNA / γ切断 / バイオマーカー / 脳神経疾患 / アミロイド / APLP1 / amyloid beta / presenilin / Treatment / micro glia / Inflammation / イブプロフェン / ワクチン療法 / マイクログリア / 抗炎症剤 / amvloid beta / apoptosis / cerebral ischemia / chaperone / amyloid apoptosis / 脳虚血 / アミロイド前駆蛋白(APP) / アミロイド蛋白(Aβ) / 小胞体(ER)ストレス / gamma-cleavage / beta-amyloid protein precursor / Amyloid-beta peptide / Notch signaling / gamma-secretase / βアミロイド蛋白前駆体 / アミロイドβ蛋白 / Notchシグナル伝達 / γ-secretase / Aβ degradation / )cell-free BACE assay / molecular chaperone / β-amyloid / プロテオソーム / カスペース / Aβ / ストレス / 小胞体 / 小胞体ストレス / アミロイド蛋白 / Microtubule / Ribosome / Apoptosis / Tau Protein / Alzheimer Disease / XIAP(X染色体関連アポトーシス阻害蛋白) / 微小管 / リボソーム / neurofibilliary tangles / double stranded RNA / tauopathy / neuronal cell death / tau Protein / リボトキシックストレス / 2本鎖RNA / リン酸化 / spricing / microsatellite / Alzheimer desease / Apolipoprotein C-II / Apolipoprotein A-II / アポリポ蛋白E / アルブミン / シスタチオニンβシンターゼ / スプライシング / マイクロサテライト / アポリポ蛋白C-II / アポリポ蛋白A-II / アルツハイマー病バイオマーカー / APL1β / γ‐セクレターゼ / CRISPR/CAS9 / γ-セクレターゼ / 脳脊髄液 / 神経変性疾患 / APL1ベータペプチド / アミロイドベータ産生機構 / 質量分析 / セクレターゼ / βAPP / GSM / Notchシグナル / MCSF / beta APP / アミロイドベータ / betaAPP Less

幹細胞技術と遺伝子編集技術を組み合わせアルツハイマー病治療戦略を洗練させるPrincipal Investigator
- Principal Investigator
  
  大河内正康
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Intramembrane proteolysis of beta-APP in a gamma-secretase independent mechanism
- Principal Investigator
  
  Yanagida Kanta
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Mechanism of presenilin/gamma secretase to produce amyloid beta
- Principal Investigator
  
  Tagami Shinji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Identification of molecules related to modulation of Amyloid beta production in human cerebrospinal fluid (CSF)
- Principal Investigator
  
  Takashi Kodama
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Increase in Abeta42 production and accelerated dissociation of Abeta42 from gamma-secretasePrincipal Investigator
- Principal Investigator
  
  Okochi Masayasu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Analysis of presenilin gamma-secretase function on Abeta and NICD generation
- Principal Investigator
  
  TAGAMI Shinji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Analysis of novel Alzheimer's disease-related peptides in human cerebrospinal fluid derived from APLP2
- Principal Investigator
  
  YANAGIDA Kanta
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Mass spectrometry analysis of human cerebrospinal fluid with psychiatric disease patients.Principal Investigator
- Principal Investigator
  
  OKOCHI Masayasu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Development of methods to promote degradation of amyloid beta
- Principal Investigator
  
  TAGAMI Shinji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Characterization of Abeta-like peptide other in brains of Alzheimer diseasePrincipal Investigator
- Principal Investigator
  
  MASAYASU Okochi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Characterization of BACE-mediated proteolysis including amyloid-beta
- Principal Investigator
  
  TAGAMI Shinji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
The mechanisms of anti-Alzheimer dicaam effects by NSAIDs
- Principal Investigator
  
  TAKASHI Morihara
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Analysis of sequential endoproteolytic process of beta-APP to establish novel therapeutic interventions
- Principal Investigator
  
  TAKEDA Masatoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Implication of ER stress in amyloid production and its application for therapeutic approach
- Principal Investigator
  
  KUDO Takashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Degradation of amyloid-beta
- Principal Investigator
  
  TAGAMI Shinji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Measurement of novel Nβ species level as a substitute for Aβ species.Principal Investigator
- Principal Investigator
  
  OKOCHI Masayasu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Notch-βペプチドを孤発性アルツハイマー病マーカーとして開発できるかPrincipal Investigator
- Principal Investigator
  
  大河内正康
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Neurodegenerative mechanism on ribotoxic stress and apoptosis
- Principal Investigator
  
  TAKEDA Masatoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Molecular mechanism of endoplasmic reticulum stress and Alzheimer disease
- Principal Investigator
  
  KUDO Takashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
活性中心を分子内移動させた人工プレセニリン発現によりAPPγ切断部位は変化するかPrincipal Investigator
- Principal Investigator
  
  大河内正康
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
アミロイドβ蛋白前駆体の膜内γ切断はエネルギー依存的かPrincipal Investigator
- Principal Investigator
  
  大河内正康
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Modification of genetic expression by intoronic microsatellite in risk genes of Alzheimer's disease
- Principal Investigator
  
  KAMINO Kouzin
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Mechanism of the nerve cell death accompanied with tau protein phosphorylation in tauopathy
- Principal Investigator
  
  TANAKA Toshihisa
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University

[Book] 日本発Aβ42サロゲートマーカーの発見と性質　―　アルツハイマー病の発症前診断マーカーへの応用の可能性2013
- Author(s)
  大河内正康
- Total Pages
  10
- Publisher
  精神神経学雑誌
- Data Source
  KAKENHI-PROJECT-22591284
[Book] アミロイドカスケードの異常を反映するAβ42サロゲートマーカーAPL1β282013
- Author(s)
  大河内正康
- Total Pages
  10
- Publisher
  老年精神医学
- Data Source
  KAKENHI-PROJECT-22591284
[Book] アルツハイマー病バイオマーカーについて2012
- Author(s)
  大河内正康
- Total Pages
  10
- Publisher
  脳21
- Data Source
  KAKENHI-PROJECT-22591284
[Book] アルツハイマー病薬開発の現状2012
- Author(s)
  大河内正康
- Total Pages
  10
- Publisher
  脳21
- Data Source
  KAKENHI-PROJECT-22591284
[Book] 認知症学-その解明と治療の最新知見III.臨床編認知症の症候学各論2011
- Author(s)
  大河内正康, 武田雅俊
- Publisher
  (株)日本臨牀社
- Data Source
  KAKENHI-PROJECT-22591284
[Book] プレセニリン研究の過去と現在2010
- Author(s)
  大河内正康、武田雅俊
- Publisher
  老年精神医学雑誌
- Data Source
  KAKENHI-PROJECT-22591284
[Book] 神経内科第72巻特別増刊号認知症診断マニュアル総論的事項-アルツハイマー病の病理過程の理解と治療薬開発 (Aβカスケード、神経栄養因子、神経伝達物質)2010
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Total Pages
  5
- Publisher
  科学評論者
- Data Source
  KAKENHI-PROJECT-20591405
[Book] 今、開発されている認知症(アルツハイマー病)の根本治療薬は?2010
- Author(s)
  大河内正康
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-22591284
[Book] 新老年学第3版アルツハイマー型認知症2010
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-20591405
[Book] アルツハイマー病Abeta42のサロゲートマーカーAPL1beta28ペプチドの発見:孤発性アルツハイマー病患者脳でAbeta42の産生増大が起こっている可能性について2010
- Author(s)
  大河内正康、田上真次、柳田寛太、武田雅俊
- Publisher
  日本神経精神薬理学雑誌
- Data Source
  KAKENHI-PROJECT-22591284
[Book] アルツハイマー病老人班に蓄積するAbeta42産生の仕組みはどこまでわかったか?また、その成果の臨床応用の可能性について2010
- Author(s)
  大河内正康、武田雅俊
- Publisher
  金芳堂脳21
- Data Source
  KAKENHI-PROJECT-22591284
[Book] 中核症状と周辺症状-アルツハイマー病アップデート2010
- Author(s)
  大河内正康、武田雅俊
- Publisher
  中外医学社 Clinical Neuroscience
- Data Source
  KAKENHI-PROJECT-22591284
[Book] 新規脳内ペプチドAPL1beta28の測定結果からアルツハイマー病をみる2010
- Author(s)
  大河内正康、田上真次、柳田寛太、武田雅俊
- Publisher
  メディカルレビュー社 Pharma Medica
- Data Source
  KAKENHI-PROJECT-22591284
[Book] 神経内科第72巻特別増刊号認知症診断マニュアル総論的事項-アルツハイマー病の病理過程の理解と治療薬開発(Aβカスケード、神経栄養因子、神経伝達物質)2010
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Publisher
  科学評論者
- Data Source
  KAKENHI-PROJECT-20591405
[Book] 新老年学第3版アルツハイマー型認知症2010
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Total Pages
  9
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-20591405
[Book] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Okochi, M., Tagami, S., Takeda, M
- Total Pages
  94
- Publisher
  Annual Report of Osaka University Academic Achievement 2007-2008
- Data Source
  KAKENHI-PROJECT-19591352
[Book] アルツハイマー病の薬物療法の実際2008
- Author(s)
  大河内正康、武田雅俊
- Publisher
  カレントテラピー
- Data Source
  KAKENHI-PROJECT-19591352
[Book] プレセニリンγセクレターゼによる切断の多様性とその変化について2008
- Author(s)
  田上真次, 大河内正康, 福森亮雄, 武田雅俊
- Publisher
  分子精神医学先端医学社
- Data Source
  KAKENHI-PROJECT-20591405
[Book] プレセニリンγセクレターゼによる切断の多様性とその変化について2008
- Author(s)
  田上真次大河内正康福森亮雄武田雅俊
- Total Pages
  4
- Publisher
  分子精神医学先端医学社
- Data Source
  KAKENHI-PROJECT-20591405
[Book] アンチエイジングと精神医学2007
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Publisher
  Journal of Otolaryngology, Head and Neck Surgery東京医学社
- Data Source
  KAKENHI-PROJECT-18591285
[Book] 老年期認知症ナビゲーター2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Total Pages
  2
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-17390318
[Book] BACEによるアミロイドベータ蛋白の切断について2006
- Author(s)
  田上真次, 大河内正康, 武田雅俊ほか
- Total Pages
  230
- Publisher
  精神薬療研究年報第38集
- Data Source
  KAKENHI-PROJECT-18591285
[Book] 脳と循環2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Total Pages
  13
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Book] 老年期認知症ナビゲーター2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Total Pages
  2
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Book] 脳と循環2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Total Pages
  13
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-17390318
[Book] アルツハイマー病 : 治療の可能性を探る「アミロイドβタンパク質産生の異常がアルツハイマー病につながる」2005
- Author(s)
  大河内正康
- Publisher
  クバプロ
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Book] Recent Progress in Alzheimer's and Parkinson's Disease2005
- Author(s)
  T.Kudo, T.Katayama, K.Imaizumi, D.Kanayama, J.Hitomi, M.Okochi, M.Tohyama, M.Takeda
- Total Pages
  383
- Publisher
  Alzheimer pathology and endoplasmic reticulum stress
- Data Source
  KAKENHI-PROJECT-17591210
[Book] アルツハイマー病:治療の可能性を探る 2005 第19回「大学と科学」公開シンポジウム講演抄録集2005
- Author(s)
  大河内正康
- Data Source
  KAKENHI-PROJECT-17390318
[Book] 痴呆とうつ心療内科2005
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Publisher
  科学評論社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Book] アルツハイマー病:治療の可能性を探る 2005 第19回「大学と科学」公開シンポジウム講演抄録集(単行本)2005
- Author(s)
  大河内正康
- Data Source
  KAKENHI-PROJECT-16591135
[Book] 日本医師会雑誌131巻、第12号、特別号精神障害の臨床アルツハイマー病の分子病態2004
- Author(s)
  大河内正康, 武田雅俊
- Publisher
  日本医師会
- Data Source
  KAKENHI-PROJECT-16591135
[Book] 日本臨床62巻増刊号1,痴呆症侯学(2)臨床編アミロイド前駆体蛋白遺伝子変異によるアルツハイマー病2004
- Author(s)
  大河内正康, 武田雅俊
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-16591135
[Book] Molecular Neurobiology of Alzheimer Disease and Related Disorders "Alzheimer's γ-secretase mechanism produces Amyloid-β-protein like peptides simultaneously with release of intracellular signaling fragments"2004
- Author(s)
  Okochi, M., Fukumori, A., Satoh, Y., Aidaralieva, N., Tanii, H., Kamino, K., Tanaka, T., Kudo, T., Takeda M.
- Publisher
  Karger Press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Book] Molecular Medicine 41 Aβの毒性発現機構2004
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-16591135
[Book] Psychiatry Today, No.4 アルツハイマー病の診断バイオマーカーの新たなコンセプト:Aβ様ペプチド2004
- Author(s)
  Okochi, M.
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-16591135
[Book] Molecular Newrobiology of Alzheimer Disease and Related Disorders, Alzheimer's γ-secretase mechanism produces Amyloid-β-protein like peptides simultaneously with release of intracellular signaling fragments2004
- Author(s)
  Okochi, M., Fukumori, A., et al.
- Publisher
  Karger Press
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Presenilin 1 Regulates NF-κB Activation via Association with Breakpoint Cluster Region and Casein Kinase II.2018
- Author(s)
  Tanaka Y, Sabharwal L, Ota M, Nakagawa I, Jiang JJ, Arima Y, Ogura H, Okochi M, Ishii M, Kamimura D, Murakami M.
- Journal Title
  
  J Immunol.
  
  Volume: 201(8) Issue: 8 Pages: 2256-2263
- DOI
  10.4049/jimmunol.1701446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10299, KAKENHI-PROJECT-17K19537
[Journal Article] Identification of small peptides in human cerebrospinal fluid upon amyloid-βdegradation2017
- Author(s)
  Mizuta N, Yanagida K, Kodama T, Tomonaga T, Takami M, Oyama H, Kudo T, Ikeda M, Takeda M, Tagami S, Okochi M
- Journal Title
  
  Neurodegener Dis
  
  Volume: 17 Issue: 2-3 Pages: 103-109
- DOI
  10.1159/000453358
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24249100, KAKENHI-PROJECT-26461746
[Journal Article] Semagacestat Is a Pseudo-Inhibitor of γ-Secretase2017
- Author(s)
  Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M.
- Journal Title
  
  Cell Rep
  
  Volume: 21 Issue: 1 Pages: 259-273
- DOI
  10.1016/j.celrep.2017.09.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10213, KAKENHI-PROJECT-17K10299, KAKENHI-PROJECT-16H05379, KAKENHI-PROJECT-26461745
[Journal Article] 最新のアルツハイマー病の血液バイオマーカー開発2016
- Author(s)
  田上　真次　大河内　正康
- Journal Title
  
  医学のあゆみ
  
  Volume: 257 Pages: 519-524
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461746
[Journal Article] 認知症のバイオマーカー　―髄液ならびに血液―2016
- Author(s)
  田上　真次　大河内　正康
- Journal Title
  
  臨床精神医学
  
  Volume: 45 Pages: 405-410
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461746
[Journal Article] γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.2014
- Author(s)
  Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 8 Pages: 51095121-51095121
- DOI
  10.1074/jbc.m113.510131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-24500433
[Journal Article] Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor2014
- Author(s)
  Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, Hara H, Imaizumi K, Maurice T, Chevallier N, Marchal S, Takeda M, Kudo T
- Journal Title
  
  Cell Death and Disease
  
  Volume: 5 Issue: 7 Pages: 1-11
- DOI
  10.1038/cddis.2014.301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25461729, KAKENHI-PROJECT-26461746
[Journal Article] γ-Secretase associated with lipid rafts : multiple interactive pathways in the stepwise processing ofβ-carboxyl-terminal fragment2014
- Author(s)
  Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M
- Journal Title
  
  J Biol Chem
  
  Volume: Vol.289 Pages: 5109-5121
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-βaccumulation modifier2014
- Author(s)
  Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: Vol.111 Pages: 2638-2643
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Relative Ratio and Level of Amyloid-β 42 Surrogate in Cerebrospinal Fluid of Familial Alzheimer Disease Patients with Presenilin 1 Mutations2014
- Author(s)
  Tagami et al.
- Journal Title
  
  Neurodegenerative Disease
  
  Volume: 13 Issue: 2-3 Pages: 166-170
- DOI
  10.1159/000355258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591234, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26461733, KAKENHI-PROJECT-26461746
[Journal Article] Absolute Quantitation of Low Abundance Plasma APL1βpeptides at Sub-fmol/mL Level by SRM/MRM without Immunoaffinity Enrichment2014
- Author(s)
  Sano S, Tagami S, Hashimoto Y, Yoshizawa-Kumagaye K, Tsunemi M, Okochi M, Tomonaga T
- Journal Title
  
  J Proteome Res
  
  Volume: Vol.13 Pages: 1012-1020
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as as amyloid beta accumulation modifier2014
- Author(s)
  Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, MA., Kimura, N., Saito, Y., Suzuki, T., Yanagida, K., Tanaka, T., Kazui, H., Kudo, T., Kodama, TS., Sato, M., Hashimoto, R., Tagami, S., Okochi, M., Ytoh, N., Nishitomi, K., Takamura, H., Katayama, T., Hashizumi, Y., Kimura, R., Kamino, K., Takeda, M
- Journal Title
  
  Proc. Acad. Natl. Sci. USA
  
  Volume: 111 Issue: 7 Pages: 2638-2643
- DOI
  10.1073/pnas.1307345111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-23791332, KAKENHI-PROJECT-24591708, KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25290039, KAKENHI-PROJECT-25293250, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-26461746, KAKENHI-PROJECT-26461747
[Journal Article] Absolute Quantitation of Low Abundance Plasma APL1β peptides at Sub-fmol/mL Level by SRM/MRM without Immunoaffinity Enrichment.2013
- Author(s)
  Sano S, Tagami S, Hashimoto Y, Yoshizawa-Kumagaye K, Tsunemi M, Okochi M, Tomonaga T.
- Journal Title
  
  J Proteome Res.
  
  Volume: 13 Issue: 2 Pages: 10121020-10121020
- DOI
  10.1021/pr4010103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-25290054
[Journal Article] γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43.2013
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M.
- Journal Title
  
  Cell Reports
  
  Volume: 3 Pages: 4251-4251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia.2013
- Author(s)
  Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M.
- Journal Title
  
  World J Biol Psychiatry
  
  Volume: 14 Pages: 100-13
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Involvement of endoplasmic reticulum stress in tauopathy.2013
- Author(s)
  Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 430(2) Issue: 2 Pages: 500-4
- DOI
  10.1016/j.bbrc.2012.12.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284, KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25251014, KAKENHI-PROJECT-25461729, KAKENHI-PROJECT-25650069
[Journal Article] γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ432013
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M
- Journal Title
  
  Cell Reports
  
  Volume: Vol.3 Pages: 42-51
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.2013
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M.
- Journal Title
  
  Cell Rep.
  
  Volume: 3(1) Issue: 1 Pages: 42-51
- DOI
  10.1364/oe.21.000322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] γ -secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ432013
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takami M,Kodama TS, Mori K, Nakayama T, Ihara Y,Takeda M
- Journal Title
  
  Cell Rep
  
  Volume: 3 Pages: 42-51
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Non-pharmacological intervention for dementia patients2012
- Author(s)
  Takeda M, Tanaka T, Okochi M, Kazui H
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: 66 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Non-pharmacological intervention for dementia patients2012
- Author(s)
  Takeda M, Tanaka T, Okochi M, Kazui H
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: 66(1) Issue: 1 Pages: 1-7
- DOI
  10.1111/j.1440-1819.2011.02304.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591514, KAKENHI-PROJECT-22591284
[Journal Article] Non-pharmacological intervention for dementia patients.2012
- Author(s)
  Takeda M, Tanaka T, Okochi M, Kazui H
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: 66 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Ab40/42 production detected using fusion constructs2012
- Author(s)
  Sato N
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 11 Pages: e48551-e48551
- DOI
  10.1371/journal.pone.0048551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390222, KAKENHI-PROJECT-22591284, KAKENHI-PROJECT-23390187, KAKENHI-PROJECT-23590874, KAKENHI-PROJECT-24659349
[Journal Article] Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs2012
- Author(s)
  Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R.
- Journal Title
  
  PLoS One
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.2011
- Author(s)
  Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 415 Issue: 3 Pages: 519-525
- DOI
  10.1016/j.bbrc.2011.10.113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2011
- Author(s)
  Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
- Journal Title
  
  World J Biol Psychiatry.2011 Dec 12
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.2011
- Author(s)
  Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
- Journal Title
  
  Psychogeriatrics.
  
  Volume: 11 Issue: 2 Pages: 90-97
- DOI
  10.1111/j.1479-8301.2011.00355.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-23591706
[Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress2011
- Author(s)
  Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: Vol.415 Pages: 519-525
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress2011
- Author(s)
  Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 415 Pages: 519-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Involvement of endoplasmic reticulum stress in tauopathy.2011
- Author(s)
  Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 430 Pages: 500-4
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Association study of KIBRA gene with memory performance in a Japanese population.2011
- Author(s)
  Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
- Journal Title
  
  World J Biol Psychiatry
  
  Volume: 11 Pages: 852-7
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death2011
- Author(s)
  Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M
- Journal Title
  
  Psychogeriatrics
  
  Volume: Vol.11 Pages: 90-97
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.2011
- Author(s)
  Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
- Journal Title
  
  Psychogeriatrics
  
  Volume: 11 Pages: 90-7
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] New drugs for Alzheimer's disease in Japan2011
- Author(s)
  Takeda M, Tanaka T, Okochi M.
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: 65 Pages: 399-404
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.2011
- Author(s)
  Sigma-1Rs are upregulated via Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 415 Pages: 519-25
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] [Behavioral and psychological symptoms of dementia]2011
- Author(s)
  Okochi M, Takeda M
- Journal Title
  
  Nihon Rinsho.
  
  Volume: 8 Pages: 308-12
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010
- Author(s)
  Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
- Journal Title
  
  Dement Geriatr Cogn Disord
  
  Volume: 30 Pages: 302-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010
- Author(s)
  Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S,Morihara T, Hashimoto R, Cacabelos R.
- Journal Title
  
  Psychiatry Clin Neurosci 64
  
  Pages: 592-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Human B2 inhibitgamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010
- Author(s)
  Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
- Journal Title
  
  J Biol Chem 285
  
  Pages: 14290-14931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010
- Author(s)
  Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
- Journal Title
  
  Dement Geriatr Cogn Disord
  
  Volume: 30 Pages: 302-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
- Author(s)
  Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
- Journal Title
  
  Psychogeriatrics
  
  Volume: 10 Pages: 117-123
- NAID
  10029771051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010
- Author(s)
  Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: 64 Pages: 592-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.2010
- Author(s)
  Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S
- Journal Title
  
  Schizophr Res.
  
  Volume: 116 Pages: 126-32
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients.2010
- Author(s)
  Okochi M, Tagami S, Takeda M
- Journal Title
  
  Neurodegener Dis.
  
  Volume: 7 Pages: 42-5
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
- Author(s)
  Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
- Journal Title
  
  Psychogeriatrics
  
  Volume: 10 Pages: 117-123
- NAID
  10029771051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Apolipoprotein E and central nervous system disorders: reviews of clinical findings.2010
- Author(s)
  Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
- Journal Title
  
  Psychiatry Clin Neurosci.
  
  Volume: 64 Pages: 592-607
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010
- Author(s)
  Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
- Journal Title
  
  BMC Complement Altern Med.
  
  Volume: 10 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients2010
- Author(s)
  Okochi, M., Tagami, S., Takeda, M.
- Journal Title
  
  Neurodegenerative Dis 7
  
  Pages: 42-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010
- Author(s)
  Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285 Pages: 14920-31
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010
- Author(s)
  Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: 64 Pages: 592-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010
- Author(s)
  Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
- Journal Title
  
  BMC Complement Altern Med. 10
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010
- Author(s)
  Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
- Journal Title
  
  BMC Complement Altern Med.
  
  Volume: 10 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
- Author(s)
  Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, FujiiK, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Take da M.
- Journal Title
  
  Psychogeriatrics.
  
  Volume: 10 Pages: 117-23
- NAID
  10029771051
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article]2010
- Author(s)
  Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
- Journal Title
  
  Dement Geriatr Cogn Disord 30
  
  Pages: 302-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010
- Author(s)
  Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 14290-14931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.2010
- Author(s)
  Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
- Journal Title
  
  Am J Med Genet B Neuropsychiatr Genet.
  
  Volume: 153 Pages: 1459-64
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010
- Author(s)
  Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 14290-14931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010
- Author(s)
  Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T
- Journal Title
  
  Dement Geriatr Cogn Disord.
  
  Volume: 30 Pages: 302-8
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
- Author(s)
  Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
- Journal Title
  
  Psychogeriatrics 10
  
  Pages: 117-123
- NAID
  10029771051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor.2009
- Author(s)
  Itoh N, Okochi, M., Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
- Journal Title
  
  Neurodegenerative Dis 6
  
  Pages: 230-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Takeda, M. Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients2009
- Author(s)
  Okochi, M., Tagami, S.
- Journal Title
  
  Neurodegenerative Dis 7
  
  Pages: 42-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system.2009
- Author(s)
  Yanagida K, Okochi, M., Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
- Journal Title
  
  EMBO Molecular Medicine 1
  
  Pages: 223-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor2009
- Author(s)
  Itoh N, Okochi, M., Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
- Journal Title
  
  Neurodegenerative Dis 6
  
  Pages: 230-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system2009
- Author(s)
  Yanagida K, Okochi, M., Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
- Journal Title
  
  EMBO Molecular Medicine 1
  
  Pages: 223-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Okochi, M., Tagami, S., Takeda, M.
- Journal Title
  
  Annual Report of Osaka University Academic Achievement 2007-2008 9
  
  Pages: 94-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Difficulty identifying spinocerebellar ataxia 17 from precedingric symptoms2008
- Author(s)
  Ohi K, Hashimoto R, Sugai F, Yasuda Y, Tagami s, Takamura H, Morihara T, Okochi M, Tanaka T, Kudo T, Sakoda s, Takeda M
- Journal Title
  
  Psychiatry and Clinical Neuroscience 62
  
  Pages: 625-625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid-β peptides from cerebrospinal fluid to peripheral blood2008
- Author(s)
  Jiang, J., Okochi, M., Tagami, S., Nishitomi, K., Yanagida, K., Nakayama, T., Tatsumi, S. -I., Mori, K., Takeda, M.
- Journal Title
  
  Psychogeriatrics 8
  
  Pages: 188-195
- NAID
  10027274800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Amyloid-beta 42 generating process may have a biological re inegulatin of Notch signaling Jpn.2008
- Author(s)
  Tagami S., Okochi M., Fukumori A., Takeda M.
- Journal Title
  
  J.Neuropsychopharmacology 28
  
  Pages: 177-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid- peptides from cerebrospinal fluid to peripheral blood.2008
- Author(s)
  Jiang J., Okochi M., Tagami S., Nishitomi K., Yanagida K., Nakayama T., Tatsumi K.,Mori K., Takeda M.
- Journal Title
  
  Psychogeriatrics 8
  
  Pages: 188-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase.2008
- Author(s)
  Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
- Journal Title
  
  Neurodegenerative Diseases 5
  
  Pages: 160-162
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M.
- Journal Title
  
  Molecular and Cellular Biology. 28
  
  Pages: 165-176
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Regulation of Notch signaling byd ynamic changes in the precision of S3 cleavage of Notch-1.2008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
- Journal Title
  
  Mol Cell Biol. 28(1)
  
  Pages: 165-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Processes of beta-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/gamma-Secretase.2008
- Author(s)
  Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
- Journal Title
  
  Neurodegener Dis. 5(3-4)
  
  Pages: 160-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation2008
- Author(s)
  Okamoto K, Mori Y, Komoda Y, Okamoto T, Okochi M, Takeda M, Suzuki T, Moriishi K, Matsuura Y
- Journal Title
  
  J Virol 82
  
  Pages: 8349-8361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Tagami S. Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M.
- Journal Title
  
  Molecular and Cellular Biology. 28
  
  Pages: 165-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Tagami, S, Okochi, M, Yanagida, K, Ikuta, A, Fukumori, A, Matsumoto, N, Ishizuka-Katsura, Y Nakayama, T, Itoh, N, Jiang, J, Nishitomi, K, Kamino, K, Morihara, T, Hashimoto, R, Tanaka, T, Kudo, T, Chiba, S, Takeda, M
- Journal Title
  
  Molecular and Cellular Biology. Jan 28
  
  Pages: 165-176
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid-β peptides from cerebrospinal fluid to peripheral blood2008
- Author(s)
  Jiang, J., Okochi, M., Tagami, S., Nishitomi, K., Yanagida, K., Nakayama, T., Tatsumi, S.-I., Mori, K., Takeda, M
- Journal Title
  
  Psychogeriatrics
  
  Pages: 188-195
- NAID
  10027274800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia2008
- Author(s)
  Takahashi H, Iwase M, Ishii R, 0hi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, like N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M
- Journal Title
  
  Neurosci Res 62
  
  Pages: 187-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.2008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
- Journal Title
  
  Mol Cell Biol. 28(1)
  
  Pages: 165-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-12008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
- Journal Title
  
  Mol Cell Biol 28(1)
  
  Pages: 165-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C viruscore protein and viral propagation.2008
- Author(s)
  Okamoto K, Mori Y, Komoda Y, Okamoto T, Okochi M, Takeda M, Suzuki T, Moriishi K, Matsuura Y.
- Journal Title
  
  J Virol 82
  
  Pages: 8349-8361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Processes of beta-amyloid and intracellular cytoplasmic domaingeneration by presenili n/gamma-secretase2008
- Author(s)
  Tagami, S, Okochi, M, Fukumori, A, Jiang, J, Yanagida, K, Nakayama, T, Morihara, T, Tanaka, T, Kudo, T, Takeda, M
- Journal Title
  
  Neurodegenerative Diseases 5
  
  Pages: 160-162
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Processes of beta-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/gamma-Secretase2008
- Author(s)
  Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M
- Journal Title
  
  Neurodegener Dis 5(3-4)
  
  Pages: 160-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.2008
- Author(s)
  Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M.
- Journal Title
  
  Neurosci Res 62
  
  Pages: 187-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Amyloid-beta 42 generating process may have a biologicalrole in regulation of Notch signaling intensity2008
- Author(s)
  Tagami S., Okochi M., Fukumori A., Takeda M
- Journal Title
  
  Jpn. J. Neuropsychopharmacology 28
  
  Pages: 177-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] アルツハイマー病の薬物療法の実際2008
- Author(s)
  大河内正康, 武田雅俊
- Journal Title
  
  カレントテラピー 26
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Macrophage colony stimulating factor is associated with exeretion of amyloid-peptides from cerebrospinal fluid to peripheral blood2008
- Author(s)
  Jiang J., Okochi M., Tagami S., Nishitomi K., Yanagida K., Nakayama T., Tatsumi K., Mori K., Takeda M
- Journal Title
  
  Psychogeriatrics 8
  
  Pages: 188-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions-real problems and future possibilities2007
- Author(s)
  Takeda, M, Okochi, M, Tagami, S, Tanaka, T, Kudo, T
- Journal Title
  
  Int Psychogeriatr 19
  
  Pages: 391-400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions--real problems and future possibilities2007
- Author(s)
  Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T
- Journal Title
  
  Int Psychogeriatr 19(3)
  
  Pages: 391-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interve ntions-real problems and future possibilities.2007
- Author(s)
  Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T.
- Journal Title
  
  Int Psychogeriatr. 19(3)
  
  Pages: 391-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions-real problems and future possibilities.2007
- Author(s)
  Takeda M, Okochi M, Tagami S. Tanaka T, Kudo T.
- Journal Title
  
  Int Psychogeriatr. 19
  
  Pages: 391-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions-real problems and future possibilities.2007
- Author(s)
  Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T.
- Journal Title
  
  International Psychogeriatrics 19
  
  Pages: 391-400
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry Apr 18;45(15)
  
  Pages: 4907-4914
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Secretion of the Notch-1 A β-like peptide 」during Notch signaling2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 28(12)
  
  Pages: 7890-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] セクレターゼ阻害薬2006
- Author(s)
  福森亮雄, 田上真次, 大河内正康, 武田雅俊
- Journal Title
  
  Pharma Medica Vol.24 No.7
  
  Pages: 4-4
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, and Takeda M.
- Journal Title
  
  Biochem Diophys Res Commun 344
  
  Pages: 525-530
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Development of new screening system for Alzheilzer disease,in vitro A・sink ,assay,toidentify the dissociation of soluble A・from fibrils2006
- Author(s)
  Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura LM, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
- Journal Title
  
  Neurobiology of Disease 22(3)
  
  Pages: 487-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci. 60 Suppl 1
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Secretion of the Notch-1 Abeta-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.2006
- Author(s)
  Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R.
- Journal Title
  
  Neurobiol Dis 22(3)
  
  Pages: 487-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Development of new screening system for Alzheimer disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils2006
- Author(s)
  Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
- Journal Title
  
  Neurobiology of Disease. 3月号予定(in press)
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  BIOCHEMISTRY 45(15)
  
  Pages: 4907-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry 45/15
  
  Pages: 4907-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. Epub
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry. Apr18;45(15)
  
  Pages: 4907-4914
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Ab induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway2006
- Author(s)
  Kanayama, D, T, Kudo, Kimura, R, Tabuchi, N, FukumoriA, Morihara, T, Tagami, S, Tanii, H, Okochi, M, Kamino, K, Tanaka, T, Imaizumi, K, Tabira, T, Takeda, M
- Journal Title
  
  Psychogeriatrics 6
  
  Pages: 100110-100110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006
- Author(s)
  Fukumori A, Okochi M.Tagami S.Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  BIOCHEMISTRY in press
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] 非ろテロイド性消炎薬(NSAIDs)のA」42産生阻害作用とその応用2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  CURRENT THERAPY Vol 24, No.3
  
  Pages: 33-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain-2006
- Author(s)
  Tanii, H, Jiang, J, Fukumori, A, Tagami, S, Okazaki, Y, Okochi, M, Takeda, M
- Journal Title
  
  J Neurosci Res 84(4)
  
  Pages: 918-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 281/12
  
  Pages: 7890-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Secretion of the Notch-1 Abeta-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Cliem. Mar24;281(12)Epub
  
  Pages: 7890-7898
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease.2006
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M and Takeda M.
- Journal Title
  
  Psychogeriatrics SUPPL.2
- NAID
  10025860692
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci. Apr;60
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Inhibition of endocytosis activates alternative degradation pathway of CAPP in cultured cells2006
- Author(s)
  Fukumori, A, Jiang, J, Tanii, H, Morihara, T, Kamino, K, Tanaka, T, Kudo, T, Itoh, N, Tagami, 5, Okochi, M, Takeda, M
- Journal Title
  
  Psychogeriatrics 6
  
  Pages: 107-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] 非ステロイド性消炎薬(NSAIDs)のAβ42産生阻幸作用とその応用2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  CURRENT THERAPY Vol.24 No.3
  
  Pages: 33-37
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Inhibition of endocytosis activates alternative degradation pathway of・APP in cultured cells2006
- Author(s)
  Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, and Takeda M
- Journal Title
  
  Psychogeriatrics Sep 6
  
  Pages: 107-113
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem 24;281(12)
  
  Pages: 7890-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] The GxGD motif of presenilin contributes to catalytic function and substrate identification of γ-secretase.2006
- Author(s)
  Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
- Journal Title
  
  J Neurosci 26/14
  
  Pages: 3821-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 3月号予定(in press)
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006
- Author(s)
  Nessa, BN, Tanaka, T, Kamino, K, Sadik, G, Ansar, AB, Kimura, R, Tanii, H, Okochi, M, Morihara, T, Tagami, S, Kudo, T, Takeda, M
- Journal Title
  
  PsychiatryClin Neurosci 60 Suppl 1
  
  Pages: 27-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Toll-like receptor 3 mediated ρhyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci. 60 Suppl 1
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] 非ステロイド性消炎薬(NSAIDs)のAβ42産生阻害作用とその応用2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  CURRENT THERAPY 3月号予定(印刷中)
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tauin human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci. Apr60 Suppi 1
  
  Pages: 527-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Ito N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem 281-12
  
  Pages: 7890-7898
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, *Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry 18;45(15)
  
  Pages: 4907-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] セクレターゼ阻害薬2006
- Author(s)
  福森亮雄, 田上真次, 大河内正康, 武田雅俊
- Journal Title
  
  Pharma Medica Vol.24 No.7
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun. Jun 2;344(2)
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M, Takeda M.
- Journal Title
  
  Psychogeriatrics Dec 6:(SUPPL.2)
- NAID
  10025860692
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry. 45(15)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci Suppl 1
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct2006
- Author(s)
  Fukumori, A, Okochi, M, Tagami, S, Jiang, J, Itoh, N, Nakayama, T, Yanagida, K, Ishizuka-Katsura Y, Morihara, T, Kamino, K, Tanaka, T, Kudo, T, Tanii, H, Ikuta, A, Haass, C, Takeda, M
- Journal Title
  
  Biochemistry 45(15)
  
  Pages: 4907-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Inhibition ofendocytosis activates alternative degradation pathway of β APP in cultured cells2006
- Author(s)
  Akio Fukumori, Jingwei Jiang, Hisashi Tanii, Takashi Morihara, Kojin Kamino, Toshihisa Tanaka, Takashi Kudo, Naohiro Ito, Shinji Tagami, Masayasu Okochi, Masatoshi Takeda
- Journal Title
  
  Psychogeiatrics 6(3)
  
  Pages: 107-113
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Biological markers for diagnosis of MCI and eurodegenerative dementia2006
- Author(s)
  Takeda M, Kudo T, Tanaka T, Kamino K, Okochi M, Tagami S
- Journal Title
  
  Functional and Moleculart Imaging of Strokeka dn Dementia
  
  Pages: 101-107
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006
- Author(s)
  Nessa, BN, Tanaka, T, Kamino, K, Sadik, G, Ansar, AB, Kimura, R, Tanii, H, Okochi, M, Morihara, T, Tagami, S, Kudo, T, Takeda, M
- Journal Title
  
  Psychiatry Clin Neurosci 60,1
  
  Pages: 527-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway.2006
- Author(s)
  .Kanayama D, T, Kudo, Kimura R, Tabuchi N, Fukumori A, Morihara T, Tagami S, Tanii H, Okochi M, Kamino K, Tanaka T, Imaizumi K, Tabira T, and Takeda M.
- Journal Title
  
  Psychogeriatrics 6
  
  Pages: 100-106
- NAID
  10019375777
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells.2006
- Author(s)
  Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, Takeda M
- Journal Title
  
  Psychogeriatrics Sep 6
  
  Pages: 107-113
- NAID
  10019375803
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in ρAlzheimer's disease2006
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M and Takeda M.
- Journal Title
  
  Psychogeriatrics Dec 6:
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, Takeda M.
- Journal Title
  
  J Neurosci Res Sep;84(4)
  
  Pages: 918-925
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Ito N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 3月予定(In press)
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Development of new screening system for Alzheimer disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils2006
- Author(s)
  Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
- Journal Title
  
  Neurobiology of Disease 22(3)
  
  Pages: 487-495
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase2006
- Author(s)
  Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
- Journal Title
  
  J Neuroscience 5(26)
  
  Pages: 3821-3828
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision a cleavage of the Notch-1 transmembrane domain2006
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, and Takeda M
- Journal Title
  
  J Neurosci Res. Sep;84(4)
  
  Pages: 918-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway2006
- Author(s)
  Daisuke Kanayama, Takashi Kudo, Ryo Kimura, Nobuhiko Tabuchi, Akio Fukumori, Takashi Morihara, Shinji Tagami, Hisashi Tanii, Masayasu Okochi, Kojin Kamino, Toshihisa Tanaka, Kazunori Imaizumi, Takeshi Tabira, Masatoshi Takeda
- Journal Title
  
  Psychogeiatrics 6(3)
  
  Pages: 100-106
- NAID
  10019375777
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M, Takeda M.
- Journal Title
  
  Psychogeriatrics. Dec6:(SUPPL.2)
- NAID
  10025860692
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, Takeda M
- Journal Title
  
  J Neurosci Res. Sep;84(4)
  
  Pages: 918-925
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006
- Author(s)
  Tagami, S, Tsujimoto, Y, Akaike, A, Takashima, A, Hasegawa, M, Ishiguro, K, Shoji, M, Ito, N, Kanemaru, K, Urakami, K, Okochi, M, Takeda, M
- Journal Title
  
  Psychogeriatrics 6 : (SUPPL.2)
- NAID
  10025860692
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M
- Journal Title
  
  Psychiatry Clin Neurosci. 60 Suppl 1
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Presenilin-Dependent γ-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct2006
- Author(s)
  Akio Fukumori, Masayasu Okochi, Shinji Tagami, Jinwei Jiang, Naohiro Itoh, Taisuke Nakayama, Kanta Yanagida, Yoshiko Ishizuka-Katsura, Takashi Morihara, Kojin Kamino, Toshihisa Tanaka, Takashi Kudo, Hisashi Tanii, Akiko Ikuta, Chistian Haass, Masatoshi Takeda
- Journal Title
  
  Biochemistry 45
  
  Pages: 4907-4914
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Steiner The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.2006
- Author(s)
  Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C
- Journal Title
  
  J Neurosci 5;26(14)
  
  Pages: 3821-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Ito N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 281.12
  
  Pages: 7890-7898
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Development of new screening system for Alzheimer disease, in vitro Aβ slnk assay, to identify the dissociation of soluble Aβ from fibrils2006
- Author(s)
  Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
- Journal Title
  
  Neurobiology of Disease. Epub
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
- Journal Title
  
  Biochem Biophys Res Commun. 344
  
  Pages: 525-530
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun 344(2)
  
  Pages: 525-530
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
- Journal Title
  
  Biochem Biophys Res Commun Jun2:344(2)
  
  Pages: 525-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
- Journal Title
  
  Biochemistry 45 (15)
  
  Pages: 4907-4914
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.2006
- Author(s)
  Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R.
- Journal Title
  
  Neurobiol Dis. 22(3)
  
  Pages: 487-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci 60 Suppl
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] The protease active site domain of γ-secretase contributes to substrate identification2006
- Author(s)
  Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner HH
- Journal Title
  
  J Neuroscience 3月号予定(in press)
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.2006
- Author(s)
  Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H.
- Journal Title
  
  J Neurosci. 5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Development of new screening system for Alzheimer disease, in vitro A・ sink assay, to identify the dissociation of soluble A・ from fibrils2006
- Author(s)
  Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
- Journal Title
  
  Neurobiol Dis 22/3
  
  Pages: 487-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] A β induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway2006
- Author(s)
  Daisuke Kanayama, Takashi Kudo, Ryo Kimura, Nobuhiko Tabuchi, Akio Fukumori, Takashi Morihara, Shinji Tagami, Hisashi Tanii, Masayasu Okochi, Kojin Kamino, Toshihisa Tanaka, Kazunori Imaizumi, Takeshi Tabira, Masatoshi Takeda
- Journal Title
  
  Psychogeiatrics 6(3)
  
  Pages: 100-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry. 18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] The protease active site domain of γ-secretase contributes to substrate identification2006
- Author(s)
  Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
- Journal Title
  
  J Neuroscience in press
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Presenilin-Dependent Y-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct2006
- Author(s)
  Akio Fukumori, Masayasu Okochi, Shinji Tagami, Jinwei Jiang, Naohiro Itoh, Taisuke Nakayama, Kanta Yanagida, Yoshiko Ishizuka-Katsura, Takashi Morihara, Kojin Kamino, Toshihisa Tanaka, Takashi Kudo, et al.
- Journal Title
  
  Biochemistry 45
  
  Pages: 4907-4914
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Inhibition of endocytosis activates alternative degradation pathway of /3 APP in cultured cells.2006
- Author(s)
  Fukumori A, Jiang J ; Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S. Okochi M, Takeda M
- Journal Title
  
  Psychogeriatrics.
  
  Pages: 107-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Thhyama M, Tabira T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun. 2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, and Takeda M.
- Journal Title
  
  Journal of Neuroscience Research 84
  
  Pages: 918-925
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Altered localization of amyloid precursor protein under endoplasmicreticulum stress2006
- Author(s)
  Kudo, T, Okumura, M, Imaizumi, K, Araki, W, Morihara, T, Tanimukai, H, Kamagata, E, Tabuchi, N, Kimura, R, Kanayama, D, Fukumori, A, Tagami, S, Okochi, M, Kubo, M, Tanii, H, Tohyama, MTabira, T, Takeda, M
- Journal Title
  
  Biochem BiophysReCommun 344(2)
  
  Pages: 525-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Inhibition of endocytosis activates alternative degradati on pathway of βAPP in cultured cells.2006
- Author(s)
  Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, and Takeda M.
- Journal Title
  
  Psychogeriatrics 6
  
  Pages: 107-113
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Altered localization of amyloid precursor protein under endoplasmis reticulum stress2006
- Author(s)
  Kudo, T, Okumura, M, Imaizumi, K, Araki, W, Morihara, T, Tanimukai, H, Kamagata, E, Tabuchi, N, Kimura, R, Kanayama, D, Fukumiri, A, Tagami, S, Okochi, M, Kubo, M, Tanii, H, Tohyama, M, Tabira, T, Takeda, M
- Journal Title
  
  Biochem Diophys Res Commun 344
  
  Pages: 525-530
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
- Journal Title
  
  Biochemistry 45
  
  Pages: 5351-5358
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endoso mes is functionally distinct2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
- Journal Title
  
  Biochemistry 45
  
  Pages: 5351-5358
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun. 344(2)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Cleavage at S3 by Presenilin/g-secretase has a diversity.2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Kudo T, Takeda M.
- Journal Title
  
  Dementia Japan 19
  
  Pages: 133-133
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] プレセニリン依存性膜内蛋白分解によるNotch-1のS3切断には多様性が存在する。2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Kudo T, Takeda M.
- Journal Title
  
  Dementia Japan 19
  
  Pages: 133-133
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The S3 cleavage site of Notch-1 by presenilin/γ-secretase has a diversity.2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Takeda M.
- Journal Title
  
  日本神経化学雑誌 44
  
  Pages: 204-204
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] γセクレターゼとNotchシグナル2005
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  Molecular Medicine 42
  
  Pages: 790-798
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The S3 cleavage site of Notch-1 by presenilin/γ-secretase has a diversity.2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Takeda M.
- Journal Title
  
  Bulletin of the Japanese Society for Neurochemistry 44
  
  Pages: 204-204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] アミロイドβタンパク質産生の異常がアルツハイマー病につなが2005
- Author(s)
  大河内正康
- Journal Title
  
  アルツハイマー病:治療の可能性を探る2005第.19回「大学と科学」公開シンポジウム講演抄録集単行本
  
  Pages: 13-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] The physiological meaning that BACE cleaves amyloid beta.2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Kudo T, Takeda M.
- Journal Title
  
  Joint meeting of the 27th annual meeting of JSBP and the 35th annual meeting of JSNP 27
  
  Pages: 206-206
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The mechanism of intracellular amyloid beta degradation2004
- Author(s)
  Tagami, S., Okochi, M., Fukumori, A., Kimura, R., Jiang, J., Takeda, M
- Journal Title
  
  9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9
  
  Pages: 97-97
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Biochemical separation of γ-cleavage of βAPP on the plasma membrane from that on the intracellular membrane2004
- Author(s)
  Fukumori, A., Okochi, M., Tagami, S, Tanii, H., Kimura, R., Jiang, J., Steiner, H., Haass, C., Kudo, T., Takeda, M.
- Journal Title
  
  9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9巻
  
  Pages: 157-157
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Possible assessment of Alzheimer's y-secretase activity by level of Aβ-like peptides2004
- Author(s)
  Okochi M, Takeda, M.
- Journal Title
  
  Psychogeriatrics 4
  
  Pages: 23-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Subcellular localization of γ-cleavage of βAPP.2004
- Author(s)
  Fukumori, A., Okochi, M., Jiang, J., Kimura, R., Tanii, H., Kudo, T., Tagami, S., Takeda, M
- Journal Title
  
  日本神経化学雑誌 47
  
  Pages: 20-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Possible assessment of Alzheimer's γ-secretase activity by level of Aβ-like peptides2004
- Author(s)
  Okochi, M., Takeda, M.
- Journal Title
  
  Psychogeriatrics 4
  
  Pages: 23-27
- NAID
  10018089800
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Aβの毒性発現機構2004
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  Molecular Medicine 41-No.4
  
  Pages: 427-431
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Aβの毒性発現機構2004
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  Molecular Medicine 41.No.4
  
  Pages: 427-431
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The mechanism of intracellular amyloid beta degradation2004
- Author(s)
  Tagami, S., Okochi, M., Fukumori, A., Kimura, R., Jiang, J., Takeda, M
- Journal Title
  
  9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9巻
  
  Pages: 97-97
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Alzheimer's γ-secretase mechanism produces Amyloid-β-protein like peptides simultaneously with release of intracellular signaling fragments.2004
- Author(s)
  Okochi.M., Fukumori, A., Satoh, Y., Aidaralieva, N., Tanii, H., Kamino, K., Tanaka, T., Kudo, T., Takeda M.
- Journal Title
  
  Molecular Neurobiology of Alzheimer Disease and Related Disorders)(Karger Press)
  
  Pages: 31-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Biochemical separation of γ-cleavage of βAPP on the plasma membrane from that on the intracellular membrane2004
- Author(s)
  Fukumori, A., Okochi, M., Tagami, S., Tanii, H., Kimura, R., Jiang, J., Steiner, H., Haass, C., Kudo, T., Takeda, M.
- Journal Title
  
  9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9
  
  Pages: 157-157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Inhibition of Aβ42 production by NSAIDS
- Author(s)
  Okochi M, Tagami S, Takeda M
- Journal Title
  
  CURRENT THERAPY 24(3)
  
  Pages: 33-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Biological markers for diagnosis of MCI and eurodegenerative dementia
- Author(s)
  Takeda M, Kudo T, TanakaT, Karnino K, Okochi M, Tagami S
- Journal Title
  
  Functional and Moleculart Imaging of Strokeka dn Dementia
  
  Pages: 101-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, TakashimaA, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K Okochi M Takeda M.
- Journal Title
  
  Psychogeriatrics. 6
- NAID
  10025860692
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S. Okazaki Y, Okochi M, Takeda M
- Journal Title
  
  J Neurosci Res. 84(4)
  
  Pages: 918-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Patent] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010
- Inventor(s)
  大河内正康, 田上真次, 武田雅俊, 西冨晃平
- Industrial Property Rights Holder
  大河内正康, 田上真次, 武田雅俊, 西冨晃平
- Filing Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-20591405
[Patent] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010
- Inventor(s)
  大河内正康、田上真次、武田雅俊、西冨晃平
- Industrial Property Rights Holder
  大河内正康、田上真次、武田雅俊、西冨晃平
- Filing Date
  2010-10-18
- Overseas
- Data Source
  KAKENHI-PROJECT-20591405
[Patent] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010
- Inventor(s)
  大河内正康、田上真次、武田雅俊、西冨晃平
- Industrial Property Rights Holder
  大河内正康、田上真次、武田雅俊、西冨晃平
- Filing Date
  2010-10-18
- Overseas
- Data Source
  KAKENHI-PROJECT-22591284
[Patent] セル・フリー・Notch切断分析方法および薬剤スクリーニング方法2004
- Inventor(s)
  大河内正康, 武田雅俊
- Industrial Property Rights Holder
  大阪TLO
- Filing Date
  2004-11-10
- Data Source
  KAKENHI-PROJECT-16591135
[Patent] 特許出願(セル・フリー・Notch切断分析方法および薬剤スクリーニング方法)2004
- Inventor(s)
  大河内正康, 武田雅俊
- Industrial Property Rights Holder
  大河内正康, 武田雅俊, 大阪TLO
- Filing Date
  2004-11-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Presentation] A brain-derived Aβ42 surrogate marker in peripheral blood2016
- Author(s)
  Shinji Tagami, Kanta Yanagida, Takeshi Tomonaga, Takeshi Ikeuchi, Masaaki Waragai, Masatoshi Takeda, Manabu Ikeda, Masayasu Okochi
- Organizer
  Neuroscience meeting 2016
- Place of Presentation
  San Diego USA
- Year and Date
  2016-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] ヒト血漿中に存在するAβペプチドのサロゲートマーカーAPL1βのLC-MS/MSによる測定2015
- Author(s)
  児玉高志、大河内正康、田上真次、柳田寛太、森原剛史、田中稔久、工藤喬、朝長毅、武田雅俊
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーション青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25461766
[Presentation] CRISP/CAS9法によるPresenilin1/2ダブルノックアウト細胞の作製2015
- Author(s)
  柳田　寛太　田上　真次　　児玉　高志　岡本　徹　松浦　善治　武田　雅俊　大河内　正康
- Organizer
  第34回　日本認知症学会　学術総会
- Place of Presentation
  リンクステーションホール青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] ヒト血漿中に存在するAβペプチドのサロゲートマーカーAPL1βのLC/MS/MSによる測定2015
- Author(s)
  児玉　高志　大河内　正康　田上　真次　柳田　寛太　森原　剛史　　田中　稔久　朝長　毅　工藤　喬　武田　雅俊
- Organizer
  第34回　日本認知症学会　学術総会
- Place of Presentation
  リンクステーションホール青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] Development of Abeta42 surrogate marker in peripheral blood2015
- Author(s)
  Shinji Tagami Shozo Sano Kanta Yanagida Takashi Kodama Naoki Mizuta Takeshi Tomonaga Masatoshi Takeda Masayasu Okochi
- Organizer
  12th World Congress Of Biological Psychiatry
- Place of Presentation
  Greece, Athens
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] 家族性アルツハイマー病の脳内でAβ４２産生は亢進しているか？2015
- Author(s)
  田上　真次　柳田　寛太　児玉　高志　新井　哲明　池内　健　武田　雅俊　大河内　正康
- Organizer
  第34回　日本認知症学会　学術総会
- Place of Presentation
  リンクステーションホール青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] アミロイドベータ産生機構解析のための細胞内ペプチドの測定2014
- Author(s)
  児玉高志、大河内正康、田上真次、柳田寛太、高見真子、井原康夫、武田雅俊
- Organizer
  第25回日本老年医学会近畿地方会
- Place of Presentation
  和歌山県立医科大学
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25461766
[Presentation] γセクレターゼの阻害と促進2014
- Author(s)
  大河内正康
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-30
- Data Source
  KAKENHI-PROJECT-26461745
[Presentation] CSF APL1β28 is a possible surrogate marker for Aβ42 production in human brains2013
- Author(s)
  Naoki Mizuta, Masayasu Okochi, Shinji Tagami,Kanta Yanagida, Takashi Kodama,Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
- Organizer
  Neuro2013
- Place of Presentation
  Kyoto
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Identification and quantitative analysis of short peptides derived from amyloid-beta peptides in living cell2013
- Author(s)
  Kodama T.S., Okochi M., Tagami S., Yanagida K., Mizuta N., Tanaka T., Morihara T., Kudo T., Takami M., Ihara Y., Takeda M.
- Organizer
  IPA's 16th International Congress
- Place of Presentation
  Seoul Korea, COEX
- Year and Date
  2013-10-02
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Identification of APLP2-derived Ab-like peptides from human Cerebrospinal fluid2013
- Author(s)
  柳田寛太、大河内正康、田上真次、児玉高志、武田雅俊
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2013-06-27
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Regulation of presenilin/gamma-secretase function; towards intervention of Alzheimer disease in future2013
- Author(s)
  Tagami S, Okochi M, Takeda M
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto, Japan (Symposium)
- Year and Date
  2013-06-26
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Regulation of presenilin/gamma-secretase function; towards intervention of Alzheimer disease in future2013
- Author(s)
  Tagami S, Okochi M, Takeda M.
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  京都国際会議場　京都
- Invited
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Elucidation of the mechanism underlying the alteration of Aβ42 ratio by g-secretase modulators.2013
- Author(s)
  Tagami S, Okochi M, Takeda M.
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego, California(USA)
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Identification and quantitative analysis of APL1ß peptides in human cerebrospinal fluid (CSF)2013
- Author(s)
  Takashi. S. Kodama, Masayasu Okochi, Sinji Tagami, Kanta Yanagida, Naoki Mizuta, Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2013-06-27
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Potential Action Mechanism of γ-Secretase Modulators2013
- Author(s)
  Okochi M
- Organizer
  AD/PD2013
- Place of Presentation
  Florence, Italy
- Year and Date
  2013-10-06
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Determination of APL1ß Peptide Concentration in Cerebrospinal Fluid (CSF) by ELISA2013
- Author(s)
  Takashi. S. Kodama, Masayasu Okochi, Sinji Tagami, Kanta Yanagida, Naoki Mizuta, Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
- Organizer
  Neuro2013
- Place of Presentation
  Kyoto, International Conference Center
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Degradation of extracellular Aβ42/43 in human brain and cultured cells2013
- Author(s)
  Naoki Mizuta, Masayasu Okochi, Shinji Tagami, Kanta Yanagida, Takashi Kodama, Mako Takami, Yasuo Ihara, Daisuke Kanayama, Takashi Morihara, Takashi Kudo, Toshihisa Tanaka, Masatoshi Takeda
- Organizer
  CTAD2013
- Place of Presentation
  San Diego
- Year and Date
  2013-11-14
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Ab42 is an intermediated stopover product of PS/g-secrease2013
- Author(s)
  Okochi M
- Organizer
  SFB seminor
- Place of Presentation
  LMU, Munich
- Invited
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Elucidation of the mechanism underlying the alteration of Aβ42 ratio by g-secretase modulators2013
- Author(s)
  Tagami S, Okochi M, Takeda M
- Organizer
  Neuroscience 2013 Nanosymposium
- Place of Presentation
  San Diego, California
- Year and Date
  2013-11-11
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] APL1β28, a new candidate biomarker for Alzheimer disease2013
- Author(s)
  Naoki Mizuta, Masayasu Okochi, Shinji Tagami, Kanta Yanagida, Takashi Kodama, Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2013-06-24
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Chracterization of brain APL2β, an Aβ-like peptide produced from APLP22012
- Author(s)
  Masayasu Okochi, Kanta Yanagida, Shinji Tagami, Takashi Kodama, Shozo Sano,Takeshi Tomonaga, Takaomi C.Saido, Masatoshi Takeda
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver Convention & Exhibition Centre, Vancouver Canada
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際2012
- Author(s)
  大河内正康田上真次柳田寛太児玉高志武田雅俊
- Organizer
  第31回日本認知症学会学術集会トピックス徹底討論「抗 Ab 療法の最新現状と徹底討論」
- Place of Presentation
  つくば国際会議場、第4 会場 2F 中ホール
- Year and Date
  2012-10-28
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] APL2βの産生メカニズムの解析(1)APLP2はプレセニリン1と2で異なる切断を受ける2012
- Author(s)
  柳田寛太, 大河内正康, 田上真次, 児玉高志, 森原剛史, 田中稔久, 工藤喬, 武田雅俊
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] アルツハイマー病のバイオマーカーと新しい診断基準2012
- Author(s)
  大河内正康
- Organizer
  第19回近畿老年期認知症研究会
- Place of Presentation
  リーガロイヤルNCB、大阪
- Invited
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] ヒト脳脊髄液中APL1βペプチドの高感度定量2012
- Author(s)
  児玉高志, 大河内正康, 田上真次, 柳田寛太, 森原剛史, 田中稔久, 工藤喬, 朝長毅, 武田雅俊
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際2012
- Author(s)
  大河内正康, 田上真次, 柳田寛太, 児玉高志, 武田雅俊
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-28
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] 「γセクレターゼ修飾薬(GSM)のアルツハイマー予防薬としての理論と実際」2012
- Author(s)
  大河内正康
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Chracterization of brain APL2β, an Aβ-like peptide produced from APLP22012
- Author(s)
  Masayasu Okochi, Kanta Yanagida, Shinji Tagami, Takashi Kodama, Shozo Sano,Takeshi Tomonaga, Takaomi C.Saido, Masatoshi Takeda
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver Convention & Exhibition Centre
- Year and Date
  2012-06-20
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] アルツハイマー病発症前診断バイオマーカーの開発2012
- Author(s)
  大河内正康
- Organizer
  第34回日本生物学的精神医学会
- Place of Presentation
  神戸国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] ラフトのγセクレターゼによるAPP膜内段階的切断機構2012
- Author(s)
  松村展敬, 高見真子, 田上真次, 大河内正康, 井原康夫, 森島真帆
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] APL2βの産生メカニズムの解析(2)APLP2はプレセニリン1と2で異なる切断を受ける2012
- Author(s)
  柳田寛太, 大河内正康, 田上真次, 児玉高志, 森原剛史, 田中稔久, 工藤喬, 武田雅俊
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] アルツハイマー病発症前診断バイオマーカーの開発脳プロ課題 F ・アミロイドβ42 産生の上流機構の解析(武田班)2012
- Author(s)
  大河内正康田上真次朝長毅武田雅俊
- Organizer
  第34回日本生物学的精神医学会
- Place of Presentation
  会場:E 会場(神戸国際会議場502)
- Year and Date
  2012-09-30
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Biochemistry of "Ab-like Peptide", a novel type of peptide family2011
- Author(s)
  Masayasu Okochi
- Organizer
  第84回日本生化学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-07-24
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] S15-4 認知症バイオマーカーと次世代認知症治療戦略2011
- Author(s)
  大河内正康
- Organizer
  第21回日本臨床精神神経薬理学会, 第41回日本神経精神薬理学会合同年会
- Place of Presentation
  第2 会場(コンコード B)シンポジウム 15 認知症の病態理解から診断・治療法へ
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Comparison of pretreatment methods for SISCAPA-SRM quantitation of Alzheimer disease biomaker peptide APL1beta in plasma2011
- Author(s)
  Shozo Sano, Shinji Tagami, Masayasu Okochi, Kumiko Yoshizawa-Kumagaye, Masahiko Tsunemi, Yoshio Kodera and Takeshi Tomonaga
- Organizer
  日本ヒトプロテオーム機構第9回大会
- Place of Presentation
  新潟市朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] βAPPファミリー蛋白は脳内では主にBACEによってsheddingを受けるが培養細胞に過剰発現させるとα-セクレターゼによる切断が増加する2011
- Author(s)
  柳田寛太, 大河内正康, 田上真次, 児玉高志, 森原剛史, 田中稔久, 工藤喬, 武田雅俊
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Absolute quantitation of plasma biomarker peptides for Alzheimer disease at pM level using SRM coupled with stable isotope standards and capture by anti-peptide antibodies2011
- Author(s)
  Shio Watanabe, Shinji Tagami, Shozo Sano, Kumiko Yoshizawa-Kumagaye, Masahiko Tsunemi, Masayasu Okochi and Takeshi Tomonaga
- Organizer
  日本ヒトプロテオーム機構第9回大会
- Place of Presentation
  新潟市朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] The 28-amino Acid Form of an APLP1-derived Ab-like Peptide is a Surrogate Marker for Ab422011
- Author(s)
  Masayasu Okochi
- Organizer
  AAICAD2011, July 16-21, 2011
- Place of Presentation
  Paris Porte de Versailles, Convention and Exhibition Center Paris, France(招待講演)
- Year and Date
  2011-07-20
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Session Title: A Return to the Basics- Molecular Decoding of the Alzheimer's Disease Pathogenesis""アルツハイマー病治療薬γセクレターゼ・モジュレーターの理論とその将来的優位性について2011
- Author(s)
  大河内正康
- Organizer
  第33回生物学的精神医学会
- Place of Presentation
  シンポジウム2・アルツハイマー病治療薬の新たな展開ホテルグランパシフィック LE DAIBA・パレロワイヤル B
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] The 28-amino Acid Form of an APLP1-derived Ab-like Peptide is a Surrogate Marker for Ab422011
- Author(s)
  Masayasu Okochi
- Organizer
  AAICAD2011
- Place of Presentation
  Paris Porte de Versailles, Convention and Exhibition Center, France
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Decrease in major amyloid beta species may trigger amyloidogenesis in vivo.2011
- Author(s)
  Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi Takashi Morihara, Hitoshi Tanimukai, Hiroaki Kazui, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda
- Organizer
  10th World Congress of Biological Psychiatry
- Place of Presentation
  Prague, Czech Republic
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] "βAPPファミリー蛋白は脳内では主にBACEによってsheddingを受けるが培養細胞に過剰発現させるとα－セクレターゼによる切断が増加する2011
- Author(s)
  柳田　寛太　大河内　正康　田上　真次　児玉　高志　森原　剛史　田中　稔久　工藤　喬　武田　雅俊
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] "Abeta蓄積修飾遺伝子KLC1 splicing variantの同定（１） APPTgマウスを用いた網羅的解析2011
- Author(s)
  林　紀行　横小路　美貴子　森原　剛史　田上　真次　大河内　正康　田中　稔久　工藤　喬　武田　雅俊
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Immuno-SRM/MRMを用いた新規アルツハイマー病血漿マーカーペプチドAPL1βの絶対定量法の確立と臨床応用2011
- Author(s)
  渡邊史生, 田上真次, 佐野聖, 三熊谷久美子, 常見雅彦, 大河内正康, 朝長毅
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] BACEとγセクレターゼによって産生される脳内Abeta様ペプチドを末梢血中で検出・同定する2011
- Author(s)
  田上真次, 大河内正康, 柳田寛太, 児玉高志, 池内健, 佐野聖, 三渡邊史, 生数井裕光, 森原剛史, 谷向仁, 田中稔久, 工藤喬, 朝長毅, 武田雅俊
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Decrease in major amyloid beta species may trigger amyloidogenesis in vivo2011
- Author(s)
  Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi Takashi Morihara, Hitoshi Tanimukai, Hiroaki Kazui, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda
- Organizer
  10th World Congress of Biological Psychiatry, Prague
- Place of Presentation
  Czech Republic
- Year and Date
  2011-05-30
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Comparison of pretreatment methods for SISCAPA-SRM quantitation of Alzheimer disease biomaker peptide APL1beta in plasma.2011
- Author(s)
  Shozo Sano, Shinji Tagami, Masayasu Okochi, Kumiko Yoshizawa-Kumagaye, Masahiko Tsunemi, Yoshio Kodera and Takeshi Tomonaga
- Organizer
  日本ヒトプロテオーム機構第9回大会
- Place of Presentation
  新潟市朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] New aspects of pathophysiology and therapeutic/diagnostic strategy of dementia The ratio of CSF APL1beta28, a surrogate marker for Abeta422010
- Author(s)
  Masa Okochi
- Organizer
  increases before onset of sporadic Alzheimer diseaseICAD2010
- Place of Presentation
  Hawaii Convention Center,Honolulu, Hawaii. Oral session
- Year and Date
  2010-07-14
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析 amyloid beta42のサロゲートマーカー、APL1beta 28について2010
- Author(s)
  田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
- Organizer
  日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  東京ベイホテル東急
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients2010
- Author(s)
  Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] The Rato of Cs Apl1eta28, a Surrogate Marker for Abeta42, Increases Beore Onset of Sporadic Alzheimer'S Disease, Alzheimer's Assoiation.2010
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takeda M.
- Organizer
  Internional Conference on Alzheimer's Disease 2010
- Place of Presentation
  Honolulu Hawaii U.S.A Tagami
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] アルツハイマー病Aβとは何か?Aβとよく似た生理ペプチドの発見とその応用についてPractical use of novel physiological peptides produced by beta-and gamma-secretases.2010
- Author(s)
  大河内正康
- Organizer
  つくばブレインサイエンスセミナー(TBSA)講演会
- Place of Presentation
  筑波大学付属病院講堂
- Year and Date
  2010-09-21
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Levels of the surrogate marker for Abeta42(i.e., APL1beta)in CSF of sporadic Alzheimer disease patients increase before the onset of its clinical symptoms2010
- Author(s)
  Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients2010
- Author(s)
  Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析amyloid beta42のサロゲートマーカー2010
- Author(s)
  田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
- Organizer
  APL1beta 28について日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  東京ボイホテル東急
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Abeta全体を産生する仕組みはアルツハイマー病で加速されているか?-患者CSFを用いた解析2010
- Author(s)
  大河内正康, 田上真次, 柳田寛太, 池内健, 秋山治彦, 徳田隆彦, 武田雅俊
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋市ウインク愛知
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients.2010
- Author(s)
  Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンボンションセンター
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析 amyloid beta42のサロゲートマーカー、APL1beta28について2010
- Author(s)
  田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
- Organizer
  日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  東京ベイホテル東急
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Determination of Amino acid sequences of several thousand peptides in human cerebrospinal fluid2010
- Author(s)
  Kodama S, Okochi M, Tagami S, Yanagida K, Nakayama T, Tatsumi S, Mori K, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease2010
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takeda M
- Organizer
  Alzheimer's Association International Conference o Alzheimer's Disease 2010
- Place of Presentation
  Honolulu Hawaii U.S.A
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease2010
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takeda M
- Organizer
  Alzheimer's Association International Conference o Alzheimer's Disease 2010
- Place of Presentation
  Honolulu Hawaii U.S.A
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Aβ様ペプチドの分泌から見えること-Aβ産生過程の発症への関与の可能性2010
- Author(s)
  大河内正康
- Organizer
  第29回日本認知症学会・シンポジウム 7
- Place of Presentation
  名古屋ウインク愛知・第2 会場
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] 末梢血中のamyloid beta42のサロゲートマーカー開発について2010
- Author(s)
  田上真次, 大河内正康, 児玉高志, 柳田寛太, 佐野聖三, 朝長毅, 武田雅俊
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋市ウインク愛知
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 病的に低下した Notch シグナルを是正する新たな方法の開発について2009
- Author(s)
  田上真次, 大河内正康
- Organizer
  第4回 Notch 研究会
- Place of Presentation
  国立遺伝学研究所講堂
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Overproduction of Aβ42 may not occur even in brain of PS1 familial AD patients in which tremendous amounts of Aβ42 accumulate in cotton wool plaques.2009
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Organizer
  第28回日本認知症学会
- Place of Presentation
  仙台、東北大学百周年記念会館
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Analysis of an Aβ-like peptide in human CSF to address how the cleavage precision of presenilin/γ-secase iltered in PS1 familiaAD pats.2009
- Author(s)
  S, Okochi M, Takeda M.
- Organizer
  InternationalConferenc on Alzheimer's Disease (ICAD)
- Place of Presentation
  Messe Wien Exhibition and Congress Center Vienna, Austria
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 病的に低下したNotchシグナルを是正する新たな方法の開発について2009
- Author(s)
  田上真次, 大河内正康
- Organizer
  第4回Notch研究会
- Place of Presentation
  国立遺伝学研究所講堂
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 家族性アルツハイマー病の発症機序において、脳内アミロイドβ42の産生増大は本当に起こっているか?2009
- Author(s)
  田上真次, 大河内正康, 柳田寛太, 中山泰亮, 児玉高志, 辰巳真一, 森康治, 武田雅俊
- Organizer
  第16回未病システム学会総会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Analysis of an Aβ-like peptide in human CSF to address how the cleavage precision of presenilin/γ-secretase is altered in PS1 familial AD patients2009
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Organizer
  International Conference on Alzheimer's Disease (ICAD)
- Place of Presentation
  Messe Wien Exhibition and Congress Center Vienna, Austria
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Overproduction of Aβ42 may not occur even in brain of PS1 familial AD patients in which tremendous amounts of Aβ42 accumulate in cotton wool plaques. -Aβ40 is "good" and Aβ42 is "bad"?2009
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Organizer
  第28回日本認知症学会
- Place of Presentation
  仙台, 東北大学百周年記念会館
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Characterization of APLP1-derived Abeta-like peptide in brains of Alzheimer disease patients2008
- Author(s)
  Okochi, M
- Organizer
  ICAD2008
- Year and Date
  2008-07-24
- Data Source
  KAKENHI-PROJECT-19591352
[Presentation] Changes in the cleavage precision of presenilin/r-secretase regulate Notch signaling intensity2008
- Author(s)
  Tagami, s., Okochi, M., Takeda, M
- Organizer
  The llth International Conference on Alzheimer's disease and Related Disorders
- Place of Presentation
  McCormick Place, Chicago, USA
- Year and Date
  2008-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Changes in the cleavage preision of presenilin/γ-secretase regulate Notch signalingtensity.2008
- Author(s)
  Tagami, S., Okochi, M., Takeda, M.
- Organizer
  The 11th International Conference on Alzheimer's disease and Related Disorders
- Place of Presentation
  McCormick Place, Chicago, USA
- Year and Date
  2008-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 「アルツハイマー病の病原性物質であるAβ42」を産生する仕組みには「細胞の分化に必須のNotchシグナル強度」を調節する生理作用がある-Aβ42産生抑制薬の開発時に予想される問題点とその解決法の模索2008
- Author(s)
  田上真次大河内正康武田雅俊
- Organizer
  第51回日本神経化学大会シンポジウム8アルツハイマー病の神経化学
- Place of Presentation
  富山国際会議場
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] アルツハイマー病の病原性物質であるAβ42」を産生する仕組みには「細胞の分化に必須のNotchシグナル強度」を調節する生理作用がある2008
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Organizer
  第51回日本神経化学大会シンポジウム8アルツハイマー病の神経化学
- Place of Presentation
  富山国際会議場
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Relation between presenilin/r-secretase modulators and Notchsignaling intensity2008
- Author(s)
  Tagami s, Okochi M, Yanagida K, Nakayama T, Kodama T, Tatsumi s, Jiang J, Mori KSakaguchi G, KatoA, Hasegawa H, NishimuraM, Takeda M
- Organizer
  第27回日本認知症学会
- Place of Presentation
  群馬県前橋テルサ
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] プレセニリンフセクレターゼ修飾薬の生理活性について2008
- Author(s)
  田上真次大河内正康武田雅俊
- Organizer
  第51回日本神経化学大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Relation between preseniln/γ -secretase modulators and Notch signaling intensity.2008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Nakayama T, Kodama T, Tatsumi S, Jiang J, Mori KSakaguchi G, Kato A, Hasegawa H, Nishimra M, Takeda M.
- Organizer
  第27回日本認知症学会
- Place of Presentation
  群馬県前橋テルサ
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Notch signaling can be up-regulated through modification ofpresenilin/r-secretase-mediated S3 cleavage2008
- Author(s)
  Tagami, s., Okochi, M., Takeda, M
- Organizer
  The 31th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  東京国際会議場
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Notch signaling can be up-regulated through modification of presenilin/γ-secretase-mediated S3 cleavage.2008
- Author(s)
  Tagami, S., Okochi, M., Takeda, M.
- Organizer
  The 31th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  東京国際会議場
- Year and Date
  2008-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Changes in a precision of S3 cleavage by presenilin/γ-secretase regulate Notch signaling.2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Changes in a precision of S3 cleavage by presenilin/y-secretase regulate Notch signaling2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  Osaka International Congress Hall
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Dynamic regulation of Notch signaling by presenilin/y-secretase2007
- Author(s)
  Tagami, S., Okochi, M., Takeda, M
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  Osaka International Congress Hall
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Dynamic regulation of Notch signaling by presenilin/γ-secretase2007
- Author(s)
  Tagami, S., Okochi, M., and Takeda M.
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Enhancement of Abeta degradation by BACE1.2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  大阪国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Changes in a precision of S3 cleavage by presenilin/γ-secretaseregulate Notch signaling.2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  大阪国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by a novel S3 cleavage diversity2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  29th JSBP
- Place of Presentation
  Sapporo convention center
- Year and Date
  2007-07-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12007
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  37th Neoroscience Meeting
- Place of Presentation
  San Diego Convention Center Room 28E
- Year and Date
  2007-11-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-1.2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
- Organizer
  37th Neoroscience Meeting
- Place of Presentation
  San Diego Convention Center Room 28E
- Year and Date
  2007-11-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Enhancement ofAbeta degradation by BACE12007
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  Osaka International Congress Hall
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by a novel S3 cleavage diversity2007
- Author(s)
  田上真次大河内正康柳田寛太生田亜希子福森亮雄森康治姜経緯西冨晃平小栗崇史中山泰亮武田雅俊
- Organizer
  第29回日本生物学的精神医学会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2007-07-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Comparison of S3 cleavage of Notch-1 withy-cleavage of BAPP by presenilin/y-secretase2006
- Author(s)
  Tagami, S., Okochi, M., Fukumori, A., Takeda, M
- Organizer
  The 10th International Conference on Alzheimer's disease and Related Disorders
- Place of Presentation
  IFEMA Feria de Madrid, Spain
- Year and Date
  2006-07-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by presenilin/□-secretase2006
- Author(s)
  田上真次大河内正康福森亮雄姜経緯森康治中山泰亮生田亜希子桂芳子小栗崇史西冨晃平伊藤尚弘柳田寛太武田雅俊
- Organizer
  第49回日本神経化学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2006-09-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Effects of multiple factors including y-secretase modifiers on the precision of Presenilin-dependent intramambranous proteolysis2006
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  25th JSDR
- Place of Presentation
  Nagoya convention center
- Year and Date
  2006-10-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by presenilin/y-secretase2006
- Author(s)
  Tagami, S., Okochi, M., Fukumori, A., Takeda, M
- Organizer
  49th JNC
- Place of Presentation
  Nagoya convention center
- Year and Date
  2006-09-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Comparison of S3 cleavage of Notch-1 with ε-cleavage of βAPP by presenilin/γ-secretase2006
- Author(s)
  Shinji Tagami, Masayasu Okochi, Akio Fukumori, and Masatoshi Takeda
- Organizer
  The 10th International Conference on Alzheimer's disease and Related Disorders
- Place of Presentation
  IFEMA Feria de Madrid, Spain
- Year and Date
  2006-07-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Effects of multiple factors including γ-secretase modifiers on the precision of Presenilin-dependent intramambranous proteolysis.2006
- Author(s)
  田上真次大河内正康福森亮雄姜経緯森康治中山泰亮生田亜希子桂芳子小栗崇史西冨晃平伊藤尚弘柳田寛太武田雅俊
- Organizer
  第25回日本認知症学会大会
- Place of Presentation
  広島国際会議場
- Year and Date
  2006-10-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] APL2βの産生メカニズムの解析（１）APLP2はプレセニリン１と２で異なる切断を受ける
- Author(s)
  柳田　寛太　大河内　正康　田上　真次　児玉　高志　森原　剛史　田中　稔久　工藤　喬　武田　雅俊
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Identification and quantitative analysis of short peptides derived from amyloid-beta peptides in living cell
- Author(s)
  Kodama T.S., Okochi M., Tagami S., Yanagida K., Mizuta N., Tanaka T., Morihara T., Kudo T., Takami M., Ihara Y., Takeda M.
- Organizer
  IPA’s 16th International Congress
- Place of Presentation
  COEX( Seoul Korea)
- Data Source
  KAKENHI-PROJECT-25461766
[Presentation] 細胞内に存在するAbeta由来のオリゴペプチドのLC-MS/MSによる測定
- Author(s)
  児玉高志、大河内正康、田上真次、柳田寛太、水田直樹、高見真子、井原康夫、武田雅俊
- Organizer
  第33回　日本認知症学会学術集会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-25461766
[Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際
- Author(s)
  大河内　正康　田上　真次　柳田　寛太　児玉　高志　武田　雅俊
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] APL2βの産生メカニズムの解析（２）APLP2はプレセニリン１と２で異なる切断を受ける
- Author(s)
  柳田　寛太　大河内　正康　田上　真次　児玉　高志　森原　剛史　田中　稔久　工藤　喬　武田　雅俊
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] 脳脊髄液中のAβ分解産物の同定
- Author(s)
  水田　直樹　大河内　正康　田上　真次　柳田　寛太　児玉　高志　　佐野　聖三　朝長　毅森原　剛史　田中　稔久　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] iPS由来ヒト大脳皮質神経細胞のAβ産生に関連する性質
- Author(s)
  大河内　正康　柳田　寛太大山　洋　児玉　高志　高見　真子　井原　康夫阪口　岳　田上　真次　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] ヒト脳脊髄液中APL1βペプチドの高感度定量
- Author(s)
  児玉　高志　大河内　正康　田上　真次　柳田　寛太　森原　剛史　田中　稔久　工藤　喬　朝長　毅　武田　雅俊
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] ラフトのγセクレターゼによるAPP膜内段階的切断機構
- Author(s)
  松村　展敬　高見　真子　田上　真次　大河内　正康　井原　康夫　森島　真帆
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] 細胞内に存在するAβ由来のオリゴペプチドのLC-MS/MSによる測定
- Author(s)
  児玉　高志　大河内　正康　田上　真次　柳田　寛太　水田　直樹　　高見　真子　井原　康夫　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] 末梢血中のAβ42サロゲートマーカー、APL1b28の開発状況について
- Author(s)
  田上　真次　大河内　正康　佐野　聖三　柳田　寛太児玉　高志　水田　直樹　　朝長　毅　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] γセクレターゼの阻害と促進
- Author(s)
  大河内　正康　田上　真次　柳田　寛太武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] γ-secretase modulatorはAD由来のiPS細胞にも効果がある
- Author(s)
  柳田　寛太　大山　洋　大河内　正康　田上　真次　児玉　高志　水田　直樹　　阪口　岳　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] Levels of an amyloid beta42 surrogate marker in CSF of familial Alzheimer disease patients
- Author(s)
  Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi Takashi Morihara, Tetsuaki Arai, Toshihisa Tanaka, Masatoshi Takeda
- Organizer
  XVI World Congress of Psychiatr
- Place of Presentation
  Madrid, Spain
- Year and Date
  2014-09-14 – 2014-09-18
- Data Source
  KAKENHI-PROJECT-26461746

1. TAGAMI Shinji (40362735)

# of Collaborated Projects: 16 results

# of Collaborated Products: 273 results
2. TAKEDA Masatoshi (00179649)

# of Collaborated Projects: 14 results

# of Collaborated Products: 267 results
3. TANAKA Toshihisa (10294068)

# of Collaborated Projects: 7 results

# of Collaborated Products: 27 results
4. KUDO Takashi (10273632)

# of Collaborated Projects: 7 results

# of Collaborated Products: 32 results
5. KAMINO Kouzin (40307955)

# of Collaborated Projects: 6 results

# of Collaborated Products: 16 results
6. YANAGIDA Kanta (70467596)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
7. KODAMA Takashi (30512131)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. MORIHARA Takashi (90403196)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
9. 谷井久志 (40346200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TAKEDA Junko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. KAZUI Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 池田学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 池田和博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 鈴木利治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MASAYASU Okochi 大河内 正康

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幹細胞技術と遺伝子編集技術を組み合わせアルツハイマー病治療戦略を洗練させるPrincipal Investigator

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Increase in Abeta42 production and accelerated dissociation of Abeta42 from gamma-secretasePrincipal Investigator

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Mass spectrometry analysis of human cerebrospinal fluid with psychiatric disease patients.Principal Investigator

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Characterization of Abeta-like peptide other in brains of Alzheimer diseasePrincipal Investigator

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MASAYASU Okochi 大河内正康

[Book] 日本発Aβ42サロゲートマーカーの発見と性質　―　アルツハイマー病の発症前診断マーカーへの応用の可能性2013