KASHIYAMA Taku 樫山拓

… Alternative Names

樫山拓カシヤマタク

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Researcher Number	90338343
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2023: 順天堂大学, 医学部, 助教 2012 – 2014: 順天堂大学, 医学部, 助教 2009 – 2010: Juntendo University, 医学部, 助教 2007: Juntendo University, 医学部, 助教 2006: 順天堂大学, 医学部, 助手 2003 – 2004: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46020:Anatomy and histopathology of nervous system-related / General pharmacology / Nerve anatomy/Neuropathology / General physiology / Neurophysiology and muscle physiology Except Principal Investigator General pharmacology / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology
Keywords	Principal Investigator アミロイドβ / BACE1 / アミロイドプラーク / アルツハイマー病 / アルツハイマー / アミロイドベータ / 神経変性疾患 / リアノジン受容体 / 神経変性突起 / 軸索輸送 … More / amyloid beta / Alzheimer's disease / Amyloid beta / APP / 輸送障害 / 変性神経突起 / ＢＡＣＥ１ / 抑制性ニューロン / シナプス / 細胞間シグナル伝達 / 神経細胞 / ErbB / ミエリン / ニューレグリン / PKC / αセクレターゼ / β細胞 / 細胞内Ca2+ストア / 細胞内Ca^<2+>ストア / 糖尿病 / インスリン / Ca^<2+>イメージング / 骨格筋 / ジヒドロピリジン受容体 / プロカイン / Ca2+ induced Ca2+ release / 興奮収縮連関 … More Except Principal Investigator 脳神経疾患 / 脂質 / 痴呆 / 薬理学 / 組換え抗体 / プロテオーム / 神経科学 / アルツハイマー病 / 認知症 / 神経変性疾患 Less

変性神経突起における輸送障害とアルツハイマー病初期病態進展機序の解明Principal Investigator
- Principal Investigator
  
  樫山拓
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明Principal Investigator
- Principal Investigator
  
  樫山拓
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Juntendo University
Analysis of relationship between neuregulin-cleavage and activity upon myelination by using visualization tecniquePrincipal Investigator
- Principal Investigator
  
  KASHIYAMA Taku
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Juntendo University
Application of a cell-free protein display technology to the high-throughput functional proteomic screen for regulators of neuron-glia interaction
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Juntendo University
Analysis of PKC-dependent amyloid-beta reduction mechanism by alpha-secretase complexPrincipal Investigator
- Principal Investigator
  
  KASHIYAMA Taku
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Juntendo University
A novel microdomain-dependent regulatory mechanism of amyloid precursor protein processing
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Juntendo University
RyRノックアウトを用いた膵β細胞インスリン分泌の細胞内 Ca^<2+>遊離の寄与に解析Principal Investigator
- Principal Investigator
  
  樫山拓
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Juntendo University
骨格筋脱分極誘発性Ca2+遊離におけるリアノジン受容体アイソフォームの機能解析Principal Investigator
- Principal Investigator
  
  樫山拓
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Juntendo University

All 2013 2012 2011 2010 2009 2008 2005 Other

All Journal Article Presentation Book Other

[Book] 生体の科学マイクロドメインスイッチング:アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシン12010
- Author(s)
  櫻井隆、樫山拓、貫名信行
- Total Pages
  6
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21700396
[Journal Article] アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシン12010
- Author(s)
  櫻井隆、樫山拓、貫名信行, マイクロドメインスイッチング
- Journal Title
  
  生体の科学 61(3)
  
  Pages: 252-256
- Data Source
  KAKENHI-PROJECT-21700396
[Journal Article] マイクロドメインスイッチング:アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシンI.2010
- Author(s)
  櫻井隆、樫山拓、貫名信行
- Journal Title
  
  生体の科学 61
  
  Pages: 252-256
- Data Source
  KAKENHI-PROJECT-20300125
[Journal Article] Engineering a novel multifunctional green fluorescent protein tag for a wide variety of protein research2009
- Author(s)
  Kobayashi T, Morone N, Kashiyama T, Oyamada H, Kurebayashi N, Murayama T
- Journal Title
  
  PLoS One 3(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700396
[Journal Article] Membrane microdomain switching : a regulatory mechanism of amyloid precursor protein processing2008
- Author(s)
  Sakurai T, Kaneko K, Okuno M, Wada K, 樫山拓, Shimizu H, Akagi T, Hashikawa T, Nukina N
- Journal Title
  
  J Cell Biol 183
  
  Pages: 339-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300125
[Journal Article] Depolarization induced Ca2+ release (DICR) involves minor CICR in 1B5 myotubes expressing frog ryanodine receptors2005
- Author(s)
  Kashiyama T, Murayama T, Allen PD, Ogawa Y
- Journal Title
  
  Journal of Pharmacological Sciences 97
  
  Pages: 131-131
- Data Source
  KAKENHI-PROJECT-15700307
[Journal Article] Minor contribution of CICR to Ca2+ release upon depolarization of 1B5 myotubes expressing frog ryanodine receptors2005
- Author(s)
  Kashiyama T, Murayama T, Allen PD, Ogawa Y
- Journal Title
  
  Biophysical Journal 88
- Data Source
  KAKENHI-PROJECT-15700307
[Presentation] Detection of intercellular signaling by BACE1-dependent proteolysis of neuregulin 1 using a cleavage site-specific antibody2013
- Author(s)
  樫山　拓、上窪裕二、櫻井隆
- Organizer
  第86回　日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24790262
[Presentation] BACE1依存的ニューレグリン1切断による隣接細胞間シグナル伝達の切断端抗体を用いた解析2012
- Author(s)
  樫山拓
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] 切断端特異的抗体を用いたBACE1依存的ニューレグリン1切断による細胞間シグナル伝達の解析2012
- Author(s)
  樫山　拓、上窪裕二、櫻井隆
- Organizer
  第127回　日本薬理学会関東部会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-24790262
[Presentation] Detection of BACE1-mediated activation of neuregulin 1-erbB signaling using a cleavage site specific antibody2011
- Author(s)
  Taku Kashiyama, Takashi Sakurai
- Organizer
  Inaugural International Academy of Sportology
- Place of Presentation
  Juntendo University
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-21700396
[Presentation] Detection of BACE1-mediated activation of neuregulin 1-erbB signaling using a cleavage site specific antibody2011
- Author(s)
  樫山拓, 櫻井隆
- Organizer
  Inaugural International Academy of Sportology
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] Detection of BACE1-mediated activation of neuregulin 1-erbB signaling using a cleavage site specific antibody2011
- Author(s)
  樫山拓、櫻井隆
- Organizer
  国際スポートロジー学会第1回学術集会
- Place of Presentation
  順天堂大学本郷キャンパス有山登記念館講堂
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-21700396
[Presentation] 切断端抗体を用いたBACE1依存的neuregulin 1シグナル伝達機構の解析2011
- Author(s)
  樫山拓、櫻井隆
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  (年会中止のため誌上発表)
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] Detection of BACE1 dependent neuregulin 1 signal using cleaved end specific antibody2011
- Author(s)
  樫山拓、櫻井隆
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-21700396
[Presentation] 切断端を特異的に認識する抗体を用いたニューレグリン切断機構の解析2010
- Author(s)
  樫山拓
- Organizer
  第123回日本薬理学会関東部会
- Place of Presentation
  栃木(自治医科大学)
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] 切断端を特異的に認識する抗体を用いたニューレグリン切断機構の解析2010
- Author(s)
  樫山拓、櫻井隆
- Organizer
  第123回日本薬理学会関東部会
- Place of Presentation
  自治医科大学地域医療情報研修センター
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-21700396
[Presentation] 切断端を特異的に認識する抗体を用いたニューレグリン切断機構の解析2010
- Author(s)
  樫山拓、櫻井隆
- Organizer
  日本薬理学会関東部会
- Place of Presentation
  自治医科大学地域医療情報研修センター
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-21700396
[Presentation] 切断端を特異的に認識する抗体を用いたニューレグリン切断機構の解析2010
- Author(s)
  樫山拓、櫻井隆
- Organizer
  第123回日本薬理学会関東部会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] Membrane microdomain switching-a regulatory mechanism of amyloid precursor protein processing2009
- Author(s)
  Sakurai T, Kashiyama T, Shimizu H, Nukina N
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸(シンポジウム)
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] マイクロドメインスイッチング:膜マイクロドメイン依存性のアミロイド前駆体蛋白質代謝制御機構2009
- Author(s)
  櫻井隆、樫山拓、清水英明、貫名信行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21700396
[Presentation] マイクロドメインスイッチング : 膜マイクロドメイン依存性の新規アミロイド前駆体蛋白質代謝制御機構2008
- Author(s)
  櫻井隆、金子貢巳、奥野弥佐子、和田浩司、樫山拓、清水英明、貫名信行
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] Membrane microdomain switching-a new regulatory mechanism of amyloid precursor protein processing2008
- Author(s)
  Sakurai T, Kaneko K, Okuno M, Wada K, Kashiyama T, Shimizu H, Nukina N
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] 切断端認識抗体を用いたニューレグリン1のBACE1切断依存的細胞間シグナル伝達の解析
- Author(s)
  樫山拓
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] 切断端特異的抗体を用いたBACE1依存的ニューレグリン1切断による細胞間シグナル伝達の解析
- Author(s)
  樫山拓
- Organizer
  第127回日本薬理学会関東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] Detection of BACE1 dependent neuregulin 1 signal using cleaved end specific antibody
- Author(s)
  樫山拓
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  (年会中止のため誌上発表)
- Data Source
  KAKENHI-PROJECT-20300125
[Presentation] Detection of BACE1 dependent neuregulin 1 signal using cleaved end specific antibody
- Author(s)
  Kashiyama T, Sakurai T
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-21700396
[]

1. SAKURAI Takashi (70225845)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. TAKASUGI Nobumasa (60436590)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. NUKINA Nobuyuki (10134595)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. ARAYA Runa (10391848)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KAMIKUBO Yuji (80509670)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MURAYAMA Takashi (10230012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NEMOTO Naoto (60509727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 桜井正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results

KASHIYAMA Taku 樫山 拓

樫山 拓 カシヤマ タク

Research Projects

Research Products

Co-Researchers

変性神経突起における輸送障害とアルツハイマー病初期病態進展機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of relationship between neuregulin-cleavage and activity upon myelination by using visualization tecniquePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of a cell-free protein display technology to the high-throughput functional proteomic screen for regulators of neuron-glia interaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of PKC-dependent amyloid-beta reduction mechanism by alpha-secretase complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel microdomain-dependent regulatory mechanism of amyloid precursor protein processing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RyRノックアウトを用いた膵β細胞インスリン分泌の細胞内 Ca^<2+>遊離の寄与に解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨格筋脱分極誘発性Ca2+遊離におけるリアノジン受容体アイソフォームの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生体の科学 マイクロドメインスイッチング:アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシン12010

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシン12010

Author(s)

Journal Title

Data Source

[Journal Article] マイクロドメインスイッチング:アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシンI.2010

Author(s)

Journal Title

Data Source

[Journal Article] Engineering a novel multifunctional green fluorescent protein tag for a wide variety of protein research2009

Author(s)

Journal Title

Data Source

[Journal Article] Membrane microdomain switching : a regulatory mechanism of amyloid precursor protein processing2008

Author(s)

Journal Title

Data Source

KASHIYAMA Taku 樫山拓

樫山拓カシヤマタク

[Book] 生体の科学マイクロドメインスイッチング:アミロイド前駆体蛋白質のマイクロドメイン依存性代謝調節とシンタキシン12010