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Kotani Norihiro  小谷 典弘

… Alternative Names

KOTANI Norihiro  小谷 典弘

小谷 典弘  コタニ ノリヒロ

Less
Researcher Number 90342782
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3739-6478
Affiliation (Current) 2025: 埼玉医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 埼玉医科大学, 医学部, 教授
2012 – 2021: 埼玉医科大学, 医学部, 准教授
2014: 埼玉医科大学, 医学部・生化学講座, 准教授
2011: 高知大学, 教育研究部・医療学系, 助教
2010: 高知大学, 教育研究部医療学系, 助教 … More
2008: Kochi University, 教育研究部・医療学系, 助教
2007: Kochi University, 医学部, 助教
2005 – 2006: 高知大学, 医学部, 助手
2003: 理研, 研究員 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Except Principal Investigator
Basic Section 52010:General internal medicine-related / Kidney internal medicine / Gastroenterology
Keywords
Principal Investigator
肺がん / 2分子会合体 / 分子会合体 / 分子間相互作用 / 膜タンパク質 / Proximity labeling / がん / 2分子会合体 / 脂質ラフト / 細胞膜上分子 … More / ウイルス / 抗体医薬 / 共通がん抗原 / 細胞外小胞 / extracellular vesicles / リキッドバイオプシー / Extracellular vesicle / EMARS / Extracellular Vesicles / Proximity Labeling / 分子標的薬 / 癌形質 / B細胞リンパ腫 / Bリンパ腫細胞 / 脂質マイクロドメイン / EBウイルス / 細胞膜上分子間相互作用 / 細胞内糖脂質 / 糖鎖 / 糖脂質 / 硫酸化糖脂質 … More
Except Principal Investigator
エクソソーム内miRNA / microRNA / HFrEF / SGLT2阻害薬 / 膜タンパク質 / 細胞間接着装置 / 腎臓 / 培養ポドサイト / 培養細胞 / 細胞間接着分子 / EMARS / ポドサイト / 細胞増殖 / 膵臓がん / O結合型糖鎖 / 膵臓学 Less
  • Research Projects

    (11 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (14 People)
  •  「共通がん抗原」発掘を目指した分子会合体がん抗原の解析Principal Investigator

    • Principal Investigator
      小谷 典弘
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Saitama Medical University
  •  エクソソーム内microRNAを介したSGLT2阻害薬の心保護メカニズムの解明

    • Principal Investigator
      関 要
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Saitama Medical University
  •  Analysis of molecular complexes expressed in extracellular vesicles for cancer diagnosisPrincipal Investigator

    • Principal Investigator
      Kotani Norihiro
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Saitama Medical University
  •  Intercellular junctional molecules of podocytes maintaining glomerular structure

    • Principal Investigator
      YAOITA EISHIN
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Niigata University
  •  Characterization of combination effects of molecular targeted reagents based on the cell membrane bi-molecular cancer targetPrincipal Investigator

    • Principal Investigator
      Kotani Norihiro
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Saitama Medical University
  •  Assessment of the influence of overexpressed-cell surface molecular complexes in cancer characteristicsPrincipal Investigator

    • Principal Investigator
      KOTANI NORIHIRO
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Saitama Medical University
  •  O-glycosylation by GalNAc-T3 in pancreatic cancer

    • Principal Investigator
      TANIUCHI Keisuke
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kochi University
  •  Characterization of signaling pathways that are regulated through cell surface molecular interaction in B cell lymphoma.Principal Investigator

    • Principal Investigator
      KOTANI Norihiro
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kochi University
  •  Characterization of cell surface molecular interactions in virus-infected host cellPrincipal Investigator

    • Principal Investigator
      KOTANI Norihiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kochi University
  •  細胞内に存在する硫酸化糖脂質の生理機能の解明Principal Investigator

    • Principal Investigator
      小谷 典弘
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kochi University
  •  ショウジョウバエを用いたアルツハイマー病βセクレターゼ活性制御因子の解析Principal Investigator

    • Principal Investigator
      小谷 典弘
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The Institute of Physical and Chemical Research

All 2023 2021 2018 2014 2013 2012 2011 2010 2008 Other

All Journal Article Presentation Patent

  • [Journal Article] Proximity Proteomics Has Potential for Extracellular Vesicle Identification.2021

    • Author(s)
      Kaneda H, Ida Y, Kuwahara R, Sato I, Nakano T, Tokuda H, Sato T, Murakoshi T, Honke K, Kotani N.
    • Journal Title

      J. Proteome Res.

      Volume: 20 Issue: 7 Pages: 3519-3531

    • DOI

      10.1021/acs.jproteome.1c00149

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06663
  • [Journal Article] Tumor-dependent secretion of close homolog of L1 results in elevation of its circulating level in mouse model for human lung tumor2018

    • Author(s)
      Kotani Norihiro、Ida Yui、Nakano Takanari、Sato Izumi、Kuwahara Ryusuke、Yamaguchi Arisa、Tomita Masahiro、Honke Koichi、Murakoshi Takayuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 501 Issue: 4 Pages: 982-987

    • DOI

      10.1016/j.bbrc.2018.05.096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03468, KAKENHI-PROJECT-15K07941, KAKENHI-PROJECT-16K08591
  • [Journal Article] Brain RVD-haemopressin, a haemoglobin-derived peptide, inhibits bombesin-induced central activation of adrenomedullary outflow in the rat2014

    • Author(s)
      Tanaka K, Shimizu T, Yanagita T, Nemoto T, Nakamura K, Taniuchi K, Dimitriadis F, Yokotani K, Saito M
    • Journal Title

      Br. J. Pharmacol.

      Volume: 171 Issue: 1 Pages: 202-213

    • DOI

      10.1111/bph.12471

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790744, KAKENHI-PROJECT-24500442, KAKENHI-PROJECT-24591013, KAKENHI-PROJECT-25461023, KAKENHI-PROJECT-25670354
  • [Journal Article] Expressed Glycosylphosphatidylinositol-AnchoredHorseradish Peroxidase Identifies Co-Clustering Molecules in Individual Lipid Raft Domains2014

    • Author(s)
      Arisa Miyagawa-Yamaguchi, Norihiro Kotani, Koichi Honke
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 3 Pages: 93054-93054

    • DOI

      10.1371/journal.pone.0093054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590082, KAKENHI-PROJECT-25670166
  • [Journal Article] Central bombesin possibly induces S-nitrosylation of cyclooxygenase-1 in pre-sympathetic neurons of rat hypothalamic paraventricular nucleus2014

    • Author(s)
      Tanaka K, Shimizu T, Higashi Y, Nakamura K, Taniuchi K, Dimitriadis F, Shimizu S, Yokotani K, Saito M.
    • Journal Title

      Life Sci.

      Volume: 100 Issue: 2 Pages: 85-96

    • DOI

      10.1016/j.lfs.2014.01.079

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790744, KAKENHI-PROJECT-24591013, KAKENHI-PROJECT-24592133, KAKENHI-PROJECT-25461023, KAKENHI-PROJECT-25670354, KAKENHI-PROJECT-26861271
  • [Journal Article] Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat2014

    • Author(s)
      Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yawata T, Higashi Y, Ueba T, Dimitriadis F, Shimizu S, Yokotani K, Saito M.
    • Journal Title

      Neuropharmacology

      Volume: 82 Pages: 19-27

    • DOI

      10.1016/j.neuropharm.2014.03.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23790744, KAKENHI-PROJECT-24591013, KAKENHI-PROJECT-24592133, KAKENHI-PROJECT-25461023, KAKENHI-PROJECT-25462267, KAKENHI-PROJECT-25670354, KAKENHI-PROJECT-26462184, KAKENHI-PROJECT-26861271
  • [Journal Article] Brain phospholipase C, diacylglycerol lipase and monoacylglycerol lipase are involved in (±)-epibatidine-induced activation of central adrenomedullary outflow in rats.2012

    • Author(s)
      Takahiro Shimizu
    • Journal Title

      European Journal of Pharmacology

      Volume: 691 Issue: 1-3 Pages: 93-102

    • DOI

      10.1016/j.ejphar.2012.07.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790744, KAKENHI-PROJECT-23790745, KAKENHI-PROJECT-24591013
  • [Journal Article] A proteomics approach to the cell surface interactome using the enzyme-mediated activation of radical sources reaction2012

    • Author(s)
      Jiang S^#, Kotani N^<#*>, Ohnishi T, Miyagawa-Yamguchi A, Tsuda M, Yamashita R, Ishiura Y, Honke K
    • Journal Title

      Proteomics

      Volume: 12 Pages: 54-62

    • Data Source
      KAKENHI-PROJECT-22790071
  • [Journal Article] BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1.2012

    • Author(s)
      Taniuchi K, Yokotani K, Saibara T
    • Journal Title

      Neoplasia

      Volume: 14 Issue: 1-3 Pages: 440-50

    • DOI

      10.1016/j.ejphar.2012.08.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591013
  • [Journal Article] BART inhibits pancreatic cancer cell invasion by PKC alpha inactivation through binding to ANX72012

    • Author(s)
      Taniuchi K, Saibara T
    • Journal Title

      PLoS One

      Volume: 7 Issue: 4 Pages: e35674-e35674

    • DOI

      10.1371/journal.pone.0035674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590849, KAKENHI-PROJECT-24590981, KAKENHI-PROJECT-24591013
  • [Journal Article] 生きている細胞の細胞表面で会合している分子を見つける2011

    • Author(s)
      本家孝一, 小谷典弘
    • Journal Title

      口腔組織培養学会誌

      Volume: 20(2) Pages: 1-8

    • Data Source
      KAKENHI-PROJECT-22790071
  • [Journal Article] 新規ラジカル反応を用いた細胞膜上分子間相互作用の解析2011

    • Author(s)
      小谷典弘, 本家孝一
    • Journal Title

      生化学

      Volume: 83(8) Pages: 754-758

    • NAID

      10029575164

    • Data Source
      KAKENHI-PROJECT-22790071
  • [Journal Article] Spatiotemporally-regulated interaction between beta1 integrin and ErbB4 that is involved in Fibronectin-dependent cell migration2011

    • Author(s)
      Yamashita R, Kotani N^*, Ishiura Y, Higashiyama S, Honke K
    • Journal Title

      J Biochem

      Volume: 149(3) Pages: 347-355

    • Data Source
      KAKENHI-PROJECT-22790071
  • [Journal Article] The EMARS reaction : A new approach to identify partners of a given molecule in membrane microdomains(review)2011

    • Author(s)
      Honke K, Kotani N
    • Journal Title

      Neurochem

      Volume: 116(5) Pages: 690-695

    • Data Source
      KAKENHI-PROJECT-22790071
  • [Journal Article] Anomalous expression of Thy1(CD90) in B-cell lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment2010

    • Author(s)
      Ishiura Y^#, Kotani N^<#*>, Yamashita R, Yamamoto H, Kozutsumi Y, Honke K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 396(2) Pages: 329-334

    • Data Source
      KAKENHI-PROJECT-22790071
  • [Journal Article] Anomalous Expression of Thy1 (CD90) in B-Cell Lymphoma Cells and Proliferation Inhibition by Anti-Thy1 Antibody Treatment2010

    • Author(s)
      Ishiura Y, Kotani N
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 396 Pages: 329-334

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Patent] 膜構造体、及び膜構造体の製造方法2023

    • Inventor(s)
      小谷典弘,山下主税
    • Industrial Property Rights Holder
      小谷典弘,山下主税
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-18K06663
  • [Patent] 新規肺がんマーカー2018

    • Inventor(s)
      小谷 典弘
    • Industrial Property Rights Holder
      埼玉医科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-18K06663
  • [Presentation] Proximity labelingによるウイルス受容体および宿主細胞膜感染因子の生理的同定2023

    • Author(s)
      小谷典弘, 山下主税
    • Organizer
      第46回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K06663
  • [Presentation] Proximity proteomicsを用いたパンデミックウイルス(共)受容体候補スクリーニング法の開発2021

    • Author(s)
      小谷 典弘, 桒原 隆亮, 中野 貴成
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K06663
  • [Presentation] 新規腫瘍抗原としての腫瘍細胞膜上分子会合体2021

    • Author(s)
      小谷典弘, 本家孝一
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K06663
  • [Presentation] GPI-アンカー型HRP融合タンパク質がつくる脂質ラフトドメイン2013

    • Author(s)
      本家孝一、山口亜利沙、 小谷典弘
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24590082
  • [Presentation] BART inhibits pancreatic cancer cell motility and invasion through Rac1 inactivation through direct binding to active forms of Rac12013

    • Author(s)
      Taniuchi K, Yokotani K, Saibara T
    • Organizer
      Ninth AACR-Japanese Cancer Association Joint Conference, 2013
    • Place of Presentation
      ハイアットリージェンシー、マウイ (米国)
    • Data Source
      KAKENHI-PROJECT-24591013
  • [Presentation] 抗体医薬の効能や安全性を向上させる分子標的治療の標的分子探索2011

    • Author(s)
      小谷典弘,石浦嘉人,大西知子,山下竜右,本家孝一
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] EMARS反応-生きている細胞の表面で任意の分子と会合する分子を同定する-第61回日本電気泳動学会(JES)シンポジウム2011

    • Author(s)
      本家孝一、小谷典弘
    • Organizer
      第7回日本臨床プロテオーム研究会(JSCP) 2011連合大会
    • Place of Presentation
      山口
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] 抗体医薬の効能や安全性を向上させる分子標的治療の標的分子探索2011

    • Author(s)
      小谷典弘, 石浦嘉人
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2011-09-22
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] HRP遺伝子発現系を用いた新規EMARS法の開発2011

    • Author(s)
      山口亜利沙、小谷典弘、本家孝一
    • Organizer
      日本糖質学会
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] Analysis of molecular clustering on the living cell membrane2011

    • Author(s)
      Honke K, Miyagawa-Yamguchi A and Kotani N
    • Organizer
      Glycobiology Japan-Netherland Joint Seminar 2011
    • Place of Presentation
      Nagoya University Graduate Scool of Medicine, Nagoya, Japan
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] A new EMARS system using HRP expressed by gene manipulation technology2011

    • Author(s)
      Yamaguchi A, Kotani N, Honke K
    • Organizer
      The 31^<th> NAITO CONFERENCE Hokkaido
    • Place of Presentation
      Japan
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] Divergence of cell surface molecular interactions in treatment of B-cell lymphoma cells with different anti-CD20 antibody clones2010

    • Author(s)
      Kotani N, Ishiura Y, Yamashita R, Honke K
    • Organizer
      he 25^<th> International Carbohydrate Symposium
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] A new approach to identify partners of a given molecule in membrane domains2010

    • Author(s)
      Honke K, Kotani N
    • Organizer
      4th ISN Special Neurochemistry Conference
    • Place of Presentation
      Sicily, Italy
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] Anomalous expression of Thy1(CD90) in B-cell Lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment2010

    • Author(s)
      Kotani N, Ishiura Y, Yamashita R, Yamamoto H, Kozutsumi Y, Honke K
    • Organizer
      GlycoT2010 Tokyo
    • Place of Presentation
      Tokyo, Japan
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] Divergence of Cell Surface Molecular Interactions in Treatment of B-cell Lymphoma Cells with Different Anti-CD20 Antibody Clones2010

    • Author(s)
      Kotani N.
    • Organizer
      The 25^<th> International Carbohydrate Symposium
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2010-08-05
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] Fluorescence-labeled arylazide is suitable for proteomic approaches of EMARS-based cell surface interactome2010

    • Author(s)
      小谷典弘、山下竜右、石浦嘉人、本家孝一
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] Anomalous expression of Thy1(CD90) in B-cell lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment2010

    • Author(s)
      Kotani N, Ishiura Y, Yamashita R, Yamamoto H, Kozutsumi Y, Honke K
    • Organizer
      The 28^<th> NAITO CONFERENCE
    • Place of Presentation
      Kanagawa, Japan
    • Data Source
      KAKENHI-PROJECT-22790071
  • [Presentation] EBウイルス陽性B細胞リンパ腫における糖鎖関連遺伝子の発現2008

    • Author(s)
      小谷典弘、石浦嘉人、山本晴美、小堤保則、本家孝一
    • Organizer
      BMB2008日本生化学会、分子生物学会合同年会
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-19790060
  • [Presentation] Inhibitory involvement of brain cannabinoid CB1 receptors in central activation of sympatho-adrenomedullary outflow induced by bombesin microinjected into the rat hypothalamic paraventricular nucleus

    • Author(s)
      Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Shimizu S, Yawata T, Higashi Y, Ueba T, Yokotani K, Saito M
    • Organizer
      17th World congress of basic & clinical pharmacology
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2014-07-13 – 2014-07-18
    • Data Source
      KAKENHI-PROJECT-24591013
  • 1.  HONKE Koichi (80190263)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 16 results
  • 2.  YAMAGUCHI ARISA (90553157)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 3.  TANIUCHI Keisuke (50626869)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  YAOITA EISHIN (00157950)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  吉田 豊 (40182795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  冨田 昌弘 (20183494)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  関 要 (90772848)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  千本松 孝明 (70216563)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  杉 佳紀 (70792977)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TAKIMOTO yuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  NAMETA masaaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  SHIMIZU Takahiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 13.  中野 秀雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  西原 利治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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