Makino Yuichi 牧野雄一

… Alternative Names

MAKINO Yuichi 牧野雄一

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Researcher Number	90345033
Other IDs	https://orcid.org/0009-0004-0853-2658
External Links
Affiliation (Current)	2026: 旭川医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 旭川医科大学, 医学部, 教授 2011 – 2018: 旭川医科大学, 医学部, 准教授 2007 – 2010: Asahikawa Medical College, 医学部, 講師 2006: Asahikawa Medical College, School of Medicine, Assistant Professor, 医学部, 特任講師 2004 – 2005: 東京大学, 医科学研究所, 助手 2002 – 2003: 東京大学, 医科学研究所, 教務職員
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / Biological Sciences / Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology Except Principal Investigator Biological Sciences / Orthopaedic surgery / Metabolomics
Keywords	Principal Investigator 低酸素 / HIF-1 / 肺高血圧症 / IPAS / 低酸素誘導性転写因子 / HIF-3α / 膠原病 / SiRNA / 血管新生 / 転写因子 … More / 低酸素応答性転写因子 / ゲノム編集 / 低酸素応答 / 標的遺伝子 / SNP / 一塩基多型 / ChREBP / マクロファージ / mRNAスプライシング / HIF-1α / T細胞 / 遺伝子改変マウス / 肺血管リモデリング / 出生後死亡 / 脂肪酸 / 肺胞構造異常 / KOマウス / 遺伝子多型 / 肺高血圧 / 遺伝子破壊動物 / ゲノム編集法 / 遺伝子転写制御 / Adrenomedullin / Si RNA / protein degradation / T cell / Hypoxia / アドレノメジュリン / 蛋白分解 / HIF-3a / エンドセリン１ / HIF / エンドセリン1 / 単核球 / 単球 / 炎症 / 関節炎 / 炎症細胞 / VEGF / 選択的スプライシング / マイクロアレイ / アポトーシス / 活性化細胞死 / T細胞受容体 … More Except Principal Investigator 発現制御 / シグナル伝達 / 核酸 / スプライシング / 転写因子 / 臨床 / 免疫学 / 転写 / バイオテクノロジー / ゲノム / 血管新生 / 遺伝子発現異常 / ChREBP / 高グルコース / 糸球体 / メサンギウム細胞 / 糖尿病性腎症 / 糖尿病 / NF-κB / 滑膜炎 / 関節リウマチ / リウマチ病学 / 癌 / 遺伝子発現 / 低酸素 / RNA / 悪性腫瘍 / 酸素センシング / 共役因子 Less

Study on molecular mechanism underlying pulmonary hypertension and dysregulation of pulmonary vascular remodeling mediated by hypoxia-inducible transcription factorPrincipal Investigator
- Principal Investigator
  
  牧野雄一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Asahikawa Medical College
Gene dysregulation by single nucleotide polymorphism of hypoxia-inducible transcription factor in molecular pathology of pulmonary hypertensionPrincipal Investigator
- Principal Investigator
  
  Makino Yuichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Asahikawa Medical College
Molecular pathology for IPAS/HIF-3a gene SNP-mediated pulmonary hypertension in connective tissue diseasePrincipal Investigator
- Principal Investigator
  
  Makino Yuichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Asahikawa Medical College
Role of IPAS/HIF-3alpha-mediated signals in the pathophysiology of pulmonary hypertension associated with connective tissue diseasePrincipal Investigator
- Principal Investigator
  
  Makino Yuichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Asahikawa Medical College
Elucidation of the regulatory mechanism for glucose-mediated pathogenic gene expression in diabetic nephropathy and its therapeutic application
- Principal Investigator
  
  Haneda Masakazu
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Asahikawa Medical College
Role of hypoxia-inducible transcription factors in regulation of immune response and its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  MAKINO Yuichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Asahikawa Medical College
マイクロRNAによるNF-κB制御を介した関節リウマチ治療戦略に関する研究
- Principal Investigator
  
  平野史倫
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Asahikawa Medical College
Mechanism of regulation of immune response by hypoxia-inducible factors and its therapeutic application to inflammatory diseasesPrincipal Investigator
- Principal Investigator
  
  MAKINO Yuichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Asahikawa Medical College
Strategise for treatment of rheumatoid synovitis on the focus of IκBβ2 expression.
- Principal Investigator
  
  HIRANO Fuminori
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Asahikawa Medical College
低酸素シグナル抑制分子IPASの発現制御法の開発とがん治療への応用Principal Investigator
- Principal Investigator
  
  牧野雄一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Asahikawa Medical College
HIF-1拮抗分子IPASの発現制御機構の解明と抗血管新生療法開発への応用Principal Investigator
- Principal Investigator
  
  牧野雄一
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of a novel therapy targeting the hypoxia response system in the immune cells for inflammatory diseases.Principal Investigator
- Principal Investigator
  
  MAKINO Yuichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Asahikawa Medical College
  The University of Tokyo
低酸素誘導性転写因子群を標的とする新規抗血管新生療法開発に関する研究Principal Investigator
- Principal Investigator
  
  牧野雄一
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
HIF-1抑制分子IPAS遺伝子の発現調節機構の解明
- Principal Investigator
  
  田中廣壽
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
低酸素応答性選択的スプライシング機構の解明と生体機能調節
- Principal Investigator
  
  田中広寿 (田中廣壽)
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
低酸素シグナルによるリンパ球機能制御機構の解明Principal Investigator
- Principal Investigator
  
  牧野雄一
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokyo
低酸素誘導性転写因子に拮抗する新規蛋白IPASのがん増殖、進展における役割
- Principal Investigator
  
  田中廣壽
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

[Book] 腎症のトピックスHypoxia-inducible factor-1 (HIF-1) ヴィジュアル糖尿病臨床のすべて『糖尿病腎症のすべて』2012
- Author(s)
  牧野雄一、羽田勝計
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23591453
[Book] Hypoxia-inducible factor-1 (HIF-1)の発現制御からだと酸素の事典2009
- Author(s)
  牧野雄一
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] HIF3A gene disruption causes abnormal alveoli structure and early neonatal death2024
- Author(s)
  Kawahata Tomoki、Tanaka Kitaru、Oyama Kyohei、Ueda Jun、Okamoto Kensaku、Makino Yuichi
- Journal Title
  
  PLOS ONE
  
  Volume: 19 Issue: 5 Pages: e0300751-e0300751
- DOI
  10.1371/journal.pone.0300751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07888, KAKENHI-PROJECT-22K06063
[Journal Article] Role of IGFBP7 in Diabetic Nephropathy: TGF-β1 Induces IGFBP7 via Smad2/4 in Human Renal Proximal Tubular Epithelial Cells.2016
- Author(s)
  Takiyama Y, Watanabe J, Honjyo J, Makino Y, Fujita Y, Tateno M, Haneda M.
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 3 Pages: 1-20
- DOI
  10.1371/journal.pone.0150897
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09372, KAKENHI-PROJECT-24390229
[Journal Article] High glucose induces platelet-derived growth factor-C via carbohydrate response element-binding protein in glomerular mesangial cells.2016
- Author(s)
  Kitsunai H, Makino Y, Sakagami H, Mizumoto K, Yanagimachi T, Atageldiyeva K, Takeda Y, Fujita Y, Abiko A, Takiyama Y, Haneda M.
- Journal Title
  
  Physiol Rep
  
  Volume: 4 Issue: 6 Pages: 1-13
- DOI
  10.14814/phy2.12730
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09372, KAKENHI-PROJECT-15K09373, KAKENHI-PROJECT-24390229
[Journal Article] Loss of HIF-1αimpairs GLUT4 translocation and glucose uptake by the skeletal muscle cells2014
- Author(s)
  Sakagami H, Makino Y, Mizumoto K, Isoe T, Takeda Y, Watanabe J, Fujita Y, Takiyama Y, Abiko A, Haneda M
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] Loss of HIF-1α impairs GLUT4 translocation and glucose uptake by the skeletal muscle cells.2014
- Author(s)
  Sakagami H, Makino Y, Mizumoto K, Isoe T, Takeda Y, Watanabe J, Fujita Y, Takiyama Y, Abiko A, Haneda M.
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: .
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390229
[Journal Article] Loss of HIF-1α impairs GLUT4 translocation and glucose uptake by the skeletal muscle cells.2014
- Author(s)
  Sakagami H, Makino Y, Mizumoto K, Isoe T, Takeda Y, Watanabe J, Fujita Y, Takiyama Y, Abiko A, Haneda M.
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 306 Issue: 9 Pages: E1065-E1076
- DOI
  10.1152/ajpendo.00597.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis2013
- Author(s)
  Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M, Aso K, Kanamori H, Ohashi T, Sato K, Nakao H, Haneda M, Yoneda M
- Journal Title
  
  J Gastroenterol
  
  Volume: 48 Pages: 491-503
- NAID
  10031169224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms2013
- Author(s)
  Khalesi E, Nakamura H, Lee KL, Putra AC, Fukazawa T, Kawahara Y, Makino Y, Poellinger L, Yuge L, Tanimoto K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 441 Pages: 499-506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms.2013
- Author(s)
  Khalesi E, Nakamura H, Leong Lee K, Chandra Putra A, Fukazawa T, Kawahara Y, Makino Y, Poellinger L, Yuge L, Tanimoto K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 441 Issue: 2 Pages: 499-506
- DOI
  10.1016/j.bbrc.2013.10.083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591453, KAKENHI-PROJECT-23592766
[Journal Article] 心腎連関:腎虚血の病態における意義2012
- Author(s)
  牧野雄一、羽田勝計
- Journal Title
  
  月刊糖尿病
  
  Volume: 4(2) Pages: 75-83
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice.2012
- Author(s)
  Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer TJ, Haneda M.
- Journal Title
  
  Diabetologia
  
  Volume: 55 Issue: 2 Pages: 404-12
- DOI
  10.1007/s00125-011-2365-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591291, KAKENHI-PROJECT-24390229
[Journal Article] Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice2012
- Author(s)
  Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer TJ, Haneda M
- Journal Title
  
  Diabetologia
  
  Volume: 55 Pages: 404-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] 糖尿病性腎症の現況と今後の展望高血糖が関わる新たな分子機構2012
- Author(s)
  牧野雄一、羽田勝計
- Journal Title
  
  Diabetes Frontier
  
  Volume: 23 (5) Pages: 535-539
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] 骨格筋のインスリン感受性制御における転写因子HIF-1αの役割の解明とインスリン抵抗性解除法開発への応用2012
- Author(s)
  牧野雄一
- Journal Title
  
  Therapeutic Research
  
  Volume: 33 (6) Pages: 843-847
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] 糖尿病性腎症の成因と病態～新たな展開～III.HIF-1α2011
- Author(s)
  牧野雄一、磯江つばさ、羽田勝計
- Journal Title
  
  日本腎臓学会誌
  
  Volume: 53(7) Pages: 1006-1009
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] シンポジウム1:糖尿病腎症の新展開腎症発症•進展と転写因子2011
- Author(s)
  牧野雄一、磯江つばさ、羽田勝計
- Journal Title
  
  日本糖尿病合併症
  
  Volume: 25(1) Pages: 36-39
- Data Source
  KAKENHI-PROJECT-23591453
[Journal Article] Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin : A Possible Role of HIF-1α Expression and Oxygen Metabolism2011
- Author(s)
  Takiyama Y, Harumi T, Watanabe J, Fujita Y, Honjo J, Shimizu N, Makino Y, Haneda M
- Journal Title
  
  Diabetes 60
  
  Pages: 981-992
- NAID
  120004606769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Met formin : A Possible Role of Hypoxia Inducible Factor-1 {alpha} Expression and Oxygen Metabolism.2011
- Author(s)
  Takiyama Y, Harumi T, Watanabe J, Fujita Y, Honjo J, Shimizu N, Makino Y, Haneda M.
- Journal Title
  
  Diabetes
  
  Volume: 60 Pages: 981-992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] High glucose activates HIF-1-mediated signal transduction in glomer ular mesangial cells through a carbohydrate response element binding protein.2010
- Author(s)
  lsoe T, Makino_Y, Mizumoto K, Sakagami H, Fulita Y, Honjo J,Takiyama Y, ltoh H, Hane da M
- Journal Title
  
  Kidney Int
  
  Volume: 78 Pages: 48-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] High glucose activates HIF-1-mediated signal transduction via carbohydrate response element binding protein in glomerular mesangial cells2010
- Author(s)
  Isoe T, Makino Y, Mizumoto K, Sakagami H, Fujita Y, Honjo J, Takiyama Y, Itoh H, Haneda M.
- Journal Title
  
  Kideny Int. 78
  
  Pages: 48-59
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] 炎症制御における低酸素誘導性転写因子群の役割2009
- Author(s)
  牧野雄一、羽田勝計
- Journal Title
  
  外科と代謝・栄養 44
  
  Pages: 225-227
- NAID
  10026699876
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] 転写因子と糖尿病性腎症2009
- Author(s)
  牧野雄一、羽田勝計
- Journal Title
  
  月刊糖尿病 1
  
  Pages: 50-58
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] 高血糖による遺伝子発現異常と腎障害2009
- Author(s)
  牧野雄一、磯江つばさ、羽田勝計
- Journal Title
  
  アンチ・エイジング医学-日本抗加齢医学会雑誌 5
  
  Pages: 196-200
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] レドックスシグナルと酸化ストレス応答の分子機構を探る2008
- Author(s)
  牧野雄一、岡本健作、羽田勝計
- Journal Title
  
  分子消化器病 5
  
  Pages: 6-11
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] Abnormal heart development and lung remodeling in mice lacking a HIF-related bHLH-PAS protein NEPAS2008
- Author(s)
  Toshiharu Yamashita, Osamu Ohneda, Masumi Nagano, Motoyuki Iemitsu, Yuichi Makino, Hirotoshi Tanaka, Takashi Miyauchi Katsutoshi Goto, Kuniko Ohneda, Yoshiaki Fujii-Kuriyama, Lorenz Poellinger, Masayuki Yamamoto
- Journal Title
  
  Mol.Cell.Biol. 28
  
  Pages: 1285-1297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] 低酸素による炎症・免疫制御-HIF-1と炎症・免疫2008
- Author(s)
  牧野雄一羽田勝計
- Journal Title
  
  医学のあゆみ 225
  
  Pages: 7203-7207
- Data Source
  KAKENHI-PROJECT-20591181
[Journal Article] Transcriptional upregulation of IPAS gene expression by HIF-1 : a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells2007
- Author(s)
  Yuichi Makino, Rie Uenishi, Kensaku Okamoto, Tsubasa Isoe, Osamu Hosono, Hirotoshi Tanaka, Arvydas Kanopka, Lorenz Poellinger, Masakazu Haneda, Chikao Morimoto
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 14073-14082
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591035
[Journal Article] Transcriptional upregulation of IPAS gene expression by HIF-1 : A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.2007
- Author(s)
  Yuichi Makino
- Journal Title
  
  J. Biol. Chem
- Data Source
  KAKENHI-PROJECT-17591035
[Journal Article] Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1) : a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells2007
- Author(s)
  Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C.
- Journal Title
  
  J Biol Chem 282(19)
  
  Pages: 14073-14082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591749
[Journal Article] Transcriptional upregulation of IPAS gene expression by HIF-1 : A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.2007
- Author(s)
  Yuichi Makino
- Journal Title
  
  J.Biol.Chem
- Data Source
  KAKENHI-PROJECT-18015012
[Journal Article] Transcriptional upregulation of IPAS gene expression by HIF-1 : A negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.2007
- Author(s)
  Yuichi Makino
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 14073-14082
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591035
[Journal Article] Transcriptional upregulation of LAPS gene expression by HIF-1: a negate-ve feedback regulatory circuit in HIF-1-mediated signaling in hypoxic c-ells2007
- Author(s)
  Yuichi Makino
- Journal Title
  
  J. Biol. Chem. 282(19)
  
  Pages: 14073-14073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18015012
[Journal Article] Physiological Activation of Hypoxia Inducible Factor - 1 in Human Skeletal Muscle2005
- Author(s)
  Helene Ameln, Thomas Gustafsson, Carl Johan Sundberg, Kensaku Okamoto, Lorenz Poellinger, Eva Jansson, Yuichi Makino
- Journal Title
  
  FASEB.J (in press)
- Data Source
  KAKENHI-PROJECT-15790509
[Journal Article] Physiological Activation of Hypoxia Inducible Factor - 1 in Human Skeletal Muscle2005
- Author(s)
  Helene Ameln, Thomas Gustafsson, Carl Johan Sundberg, Kensaku Okamoto, Lorenz Poellinger, Eva Jansson, Yuichi Makino
- Journal Title
  
  FASEB.J (in press)
- Data Source
  KAKENHI-PROJECT-16023221
[Journal Article] TCR-engagement increases HIF-1α protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells2005
- Author(s)
  Hiroshi Nakamura, Yuichi Makino, Kensaku Okamoto, et al.
- Journal Title
  
  J.Immunol. (印刷中)
- Data Source
  KAKENHI-PROJECT-15030212
[Journal Article] 低酸素シグナルによる末梢でのT細胞の制御2005
- Author(s)
  牧野雄一, 森本幾夫, 田中廣壽
- Journal Title
  
  臨床免疫 43巻、1号
  
  Pages: 92-96
- NAID
  40006610625
- Data Source
  KAKENHI-PROJECT-15790509
[Journal Article] IPASによる低酸素応答性遺伝子発現の制御2004
- Author(s)
  牧野雄一
- Journal Title
  
  臨床免疫 41巻、4号
  
  Pages: 472-476
- NAID
  40006192444
- Data Source
  KAKENHI-PROJECT-16023221
[Presentation] 肺高血圧症に関連するHIF-3α遺伝子一塩基多型とエンドセリン遺伝子制御異常2019
- Author(s)
  牧野雄一
- Organizer
  第4回生活習慣病とがんの代謝栄養メカニズム研究会
- Data Source
  KAKENHI-PROJECT-17K09964
[Presentation] 膠原病性肺高血圧患者に見いだされたHypoxia-inducible factor-3a遺伝子一塩基多型によるエンドセリン遺伝子発現制御異常2016
- Author(s)
  水元克俊、高取恭平、高取清香、吉本良太、江口耕平、藤代大介、児玉暁、小林厚志、岡本健作、飯田貴久、川口鎮司、牧野雄一
- Organizer
  第60回日本リウマチ学会総会•学術集会
- Place of Presentation
  横浜市
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26461456
[Presentation] 膠原病性肺高血圧症における Hypoxia-inducible factor-3α遺伝子一塩基多型とエンドセリン1遺伝子発現制異常2016
- Author(s)
  牧野雄一、川口鎮司、水元克俊
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26461456
[Presentation] High glucose upregulates membrane-bound transcription factor peptidase site1 through carbohydrate response element binding protein in mesangial cells2015
- Author(s)
  tageldiyeva K, Makino Y, Kitsunai H, Mizumoto K, Yanagimachi T, Fujita Y, Abiko A, Takiyama Y,and Haneda M
- Organizer
  14th Korea-Japan Diabetic Nephropathy Symposium
- Place of Presentation
  Seoul, KOrea
- Year and Date
  2015-10-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390229
[Presentation] Pulmonary arterial hypertension-associated single nucleotide polymorphisms of hypoxia-inducible factor-3α gene cause constitutive activation of the endothelin-1 gene promoter.2015
- Author(s)
  Mizumoto K, Takatori K, Takatori S, Yoshimoto R, Eguchi K, Fujishiro D, Kodama S, Kobayashi A, Okamoto K, Kawaguchi Y,Haneda M, and Makino Y
- Organizer
  American College of Rheumatology Annual Meeting,2015
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461456
[Presentation] igh glucose induces membrane-bound transcription factor peptidase site1 via carbohydrate response element binding protein to modulate ER stress in mesangial cells2015
- Author(s)
  Makino Y, Kitsunai H, Atageldiyeva K, Mizumoto K, Yanagimachi T, Fujita Y, Abiko A, Takiyama Y,and Haneda M
- Organizer
  51th Annual Meeting of the European Association for the Study of Diabetes
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24390229
[Presentation] グルコース応答性転写因子ChREBPが誘導するメサンギウム細胞における遺伝子発現の変化2013
- Author(s)
  牧野雄一、橘内博哉、坂上英充、柳町剛司、藤田征弘、安孫子亜津子、滝山由美、羽田勝計
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-24390229
[Presentation] グルコース応答性転写因子ChREBPが誘導するメサンギウム細胞における遺伝子発現の変化2013
- Author(s)
  牧野雄一、橘内博哉、坂上英充、柳町剛司、藤田征弘、安孫子亜津子、滝山由美、羽田勝計
- Organizer
  第86回日本内分泌学会学術総会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] グルコース応答性転写因子ChREBPはメサンギウム細胞においてplatelet-derived growth factor(PDGF)-C発現を誘導する2013
- Author(s)
  橘内博哉,牧野雄一,坂上英充,水元克俊、柳町剛司,竹田安孝、藤田征弘,安孫子亜津子,滝山由美,羽田勝計
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] グルコース応答性転写因子ChREBPはメサンギウム細胞においてplatelet-derived growth factor(PDGF)-C発現を誘導する2013
- Author(s)
  橘内博哉, 牧野雄一, 坂上英充, 水元克俊、柳町剛司, 竹田安孝、藤田征弘, 安孫子亜津子, 滝山由美, 羽田勝計
- Organizer
  第56回日本糖尿病学会年次学術集会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24390229
[Presentation] 糖尿病性腎症の成因ー転写因子を中心にー2013
- Author(s)
  牧野雄一、羽田勝計
- Organizer
  第47回糖尿学の進歩シンポジウム4:糖尿病性腎症の進歩—最近の進歩
- Place of Presentation
  四日市市
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] 骨格筋のインスリン感受性制御における転写因子HIF-1αの役割の解明とインスリン抵抗性解除法開発への応用2012
- Author(s)
  牧野雄一
- Organizer
  第8回メタボリックシンドローム研究会
- Place of Presentation
  東京都
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] HIF-1αis a determinant of insulin-dependent glucose uptake by Skeletal Muscle Cells2012
- Author(s)
  Yuichi Makino, Hidemitsu Sakagami, Shuhei Tomita, Katsutoshi Mizumoto, Kensaku Okamoto, Hiroya Kitsunai, Yukihiro Fujita, Yumi Takiyama, and Masakazu Haneda
- Organizer
  Keystone Symposia, Advances in Hypoxic Signaling : From Bench to Bedside
- Place of Presentation
  Banff, Canada
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] Critical involvement of HIF-1αin regulation of insulin-dependent GLUT4 translocation and glucose uptake by skeletal muscle cells2012
- Author(s)
  Yuichi Makino, Hidemitsu Sakagami, Hiroya Kitsunai, Shuhei Tomita, Kensaku Okamoto, Yukihiro Fujita, Yumi Takiyama, and Masakazu Haneda
- Organizer
  The 33^<rd> Naito Conference on Oxygen Biology : Hypoxia, Oxidative Stress and Diseases
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] Regulation of IPAS expression; a model for hypoxia-inducible alternative splicing2012
- Author(s)
  Yuichi Makino
- Organizer
  Singapore SGP seminar
- Place of Presentation
  Singapore
- Year and Date
  2012-08-17
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] グルコース応答性転写因子ChREBPがメサンギウム細胞において制御する遺伝子群の探索2012
- Author(s)
  橘内博哉,牧野雄一,坂上英充,柳町剛司,藤田征弘,安孫子亜津子,滝山由美,羽田勝計
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] High glucose induces platelet derived growth factor C (PDGF-C) expression in glomerular mesangial cells via a glucose responsive transcription factor, carbohydrate response element binding protein (ChREBP)2012
- Author(s)
  Hiroya Kitsunai, Yuichi Makino, Hidemitsu Sakagami, Katsutoshi Mizumoto, Tsuyoshi Yanagimachi, Yasutaka Takeda, Yukihiro Fujita, Atsuko Abiko, Yumi Takiyama, and Masakazu Haneda
- Organizer
  72^<th > Scientific Sessions, American Diabetes Association
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] 骨格筋のインスリン感受性制御におけるHIF-1αの役割2011
- Author(s)
  坂上英充、牧野雄一、水元克俊、冨田修平、羽田勝計
- Organizer
  第8回がんとハイポキシア研究会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] Knockdown of HIF-1αabrogates insulin-stimulated glucose uptake in skeletal muscle cells2011
- Author(s)
  Hidemitsu Sakagami, Yuichi Makino, Hiroya Kitsunai, Katsutoshi Mizumoto, Yukihiro Fujita, Yumi Takiyama, Atsuko Abiko, Masakazu Haneda
- Organizer
  71^<th > Scientific Sessions, American Diabetes Association
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] 骨格筋のインスリン感受性制御における転写因子HIF-1αの役割2011
- Author(s)
  牧野雄一、坂上英充、藤田征弘、滝山由美、羽田勝計
- Organizer
  第84回日本内分泌学会学術総会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] 低酸素応答システムよる生体機能調節機構2011
- Author(s)
  牧野雄一
- Organizer
  第45回北海道リウマチ膠原病談話会教育講演
- Place of Presentation
  札幌市
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] HIF-1αは骨格筋におけるインスリン依存性糖取込みの制御に重要である2011
- Author(s)
  牧野雄一、坂上英充、藤田征弘、滝山由美、藤代大介、児玉暁、小林厚志、小村景司、岡本健作、羽田勝計
- Organizer
  第29回内分泌代謝学サマーセミナー
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23591453
[Presentation] 糖尿病性腎症糸球体病変における転写因子HIF-1の活性化2010
- Author(s)
  牧野雄一, 他
- Organizer
  第3回生活習慣病の転写・シグナルネットワーク研究会
- Place of Presentation
  鎌倉市
- Year and Date
  2010-02-20
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] Role of HIF-1α in regulation of insulin-dependent glucose uptake by Skeletal Muscle Cells2010
- Author(s)
  Makino Y, et al.
- Organizer
  The 3^<rd> Insulin Resistance in Metabolic Disease Forum
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2010-11-21
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] The Glucose-Responsive Transcription Factor ChREBP Activates HIF-1-Mediated Gene Expression in Glomerular Mesangial Cells2010
- Author(s)
  Makino Y, et al
- Organizer
  American Diabetes Association 70^<th> Scientific Sessions
- Place of Presentation
  Orlando, USA
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] Role of hypoxia-independent activation of HIF-1 by high glucose in diabetic glomerulopathy2010
- Author(s)
  Makino Y, et al
- Organizer
  Keystone symposia, Hypoxia : Molecular mechanisms of oxygen sensing and response pathways
- Place of Presentation
  Keystone, USA
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] 低酸素応答性転写因子群による遺伝子発現調節機構2010
- Author(s)
  牧野雄一
- Organizer
  第98回北海道癌談話会例会
- Place of Presentation
  札幌市
- Year and Date
  2010-09-19
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] High glucose activates hypoxia-inducible factor-mediated signals via carbohydrate response element binding protein in human glomerular mesangial cells2009
- Author(s)
  Makino Y, et al
- Organizer
  American Diabetes Association 69^<th> Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] High glucose activates the hypoxia-inducible factor-1a (HIF-1a)-mediated gene expression in human glomerular mesangial cells.2009
- Author(s)
  Makino Y, et al
- Organizer
  The 15^<th> Korea-Japan Symposium on Diabetes Mellitus
- Place of Presentation
  Jeju, Kores
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] 低酸素応答性転写因子による生体機能調節機構2009
- Author(s)
  牧野雄一
- Organizer
  日本生化学会北海道支部・日本生物物理学会北海道支部・北海道分子生物研究会 2009年度合同シンポジウム
- Place of Presentation
  札幌市
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] 血管新生抑制分子IPASによるコラーゲン誘導関節炎の抑制2009
- Author(s)
  牧野雄一, 他
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] 炎症制御における低酸素誘導性転写因子群の役割2009
- Author(s)
  牧野雄一
- Organizer
  日本外科代謝栄養学会第46回学術集会
- Place of Presentation
  東京都
- Year and Date
  2009-07-09
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] インスリン依存性糖取込みにおけるHIF-1αの役割2009
- Author(s)
  牧野雄一, 他
- Organizer
  第7回がんとハイポキシア研究会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] 高グルコースはメサンギウム細胞においてHIF-1を介した転写調節系を作動させる2008
- Author(s)
  牧野雄一, 他
- Organizer
  第23回日本糖尿病合併症学会
- Place of Presentation
  日本都市センター、東京都
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] 高グルコースによるHIFシグナルの活性化2008
- Author(s)
  牧野雄一, 他
- Organizer
  第6回がんとハイポキシア研究会
- Place of Presentation
  広島市
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] Negative feedback regulation of gene expression in hypoxic cells2008
- Author(s)
  Makino Y.
- Organizer
  The 36th Annual Meeting of International Society on Oxygen Transport to Tissue
- Place of Presentation
  Sapporo, Japan(Invited lecture 7)
- Data Source
  KAKENHI-PROJECT-20591181
[Presentation] 膠原病性肺高血圧症におけるHypoxia inducible factor-3α(HIF-3α)遺伝子一塩基多型(SNP)とHIFシグナルの変容
- Author(s)
  牧野雄一、水元克俊、吉本良太、江口耕平、藤代大介、児玉暁、小林厚志、岡本健作、川口鎮司、羽田勝計
- Organizer
  日本臨床分子医学会
- Place of Presentation
  京都市
- Year and Date
  2015-04-10 – 2015-04-11
- Data Source
  KAKENHI-PROJECT-26461456
[Presentation] グルコース応答性転写因子ChREBPはメサンギウム細胞においてplatelet-derived growth factor(PDGF)-C発現を誘導する
- Author(s)
  牧野雄一、橘内博哉、水元克俊、柳町剛司、Kuralay　Atageldiyeva、藤田征弘、安孫子亜津子、滝山由美、羽田勝計
- Organizer
  第51回日本臨床分子医学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-24390229
[Presentation] Genome location analysis identified platelet derived growth factor-C (PDGF-C) as a target gene of carbohydrate response element binding protein in glomerular mesnagial cells in high glucose ambience
- Author(s)
  YUICHI MAKINO, HIROYA KITSUNAI, KURALAY ATAGELDIYEVA, KATSUTOSHI MIZUMOTO, TSUYOSHI YANAGIMACHI, YUKIHIRO FUJITA, ATSUKO ABIKO, YUMI TAKIYAMA, MASAKAZU HANEDA
- Organizer
  Japan Korea diabetic nephropathy study group
- Place of Presentation
  Kanazawa, JApan
- Year and Date
  2014-09-26 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-24390229
[Presentation] Genome Wide Analysis Of High Glucose-mediated Gene Regulation In Glomerular Mesangial Cells; Induction Of Platelet Derived Growth Factor-C Via Carbohydrate Response Element Binding Protein In Diabetic Kidney
- Author(s)
  YUICHI MAKINO, HIROYA KITSUNAI, KATSUTOSHI MIZUMOTO, HIDEMITSU SAKAGAMI, TSUYOSHI YANAGIMACHI, YUKIHIRO FUJITA, ATSUKO ABIKO, YUMI TAKIYAMA, MASAKAZU HANEDA
- Organizer
  American Diabetes Association: 74th Scientific Sessions
- Place of Presentation
  米国、サンフランシスコ市
- Year and Date
  2014-06-12 – 2014-06-18
- Data Source
  KAKENHI-PROJECT-24390229

1. 田中廣壽 (00171794)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 川口鎮司 (90297549)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. HIRANO Fuminori (60250552)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OKAMOTO Kensaku (80396879)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. HANEDA Masakazu (00124751)

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
6. KOMURA Keiji (10396385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUJITA YUKIHIRO (20451461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
8. 本庄潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 滝山由美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Makino Yuichi 牧野 雄一

MAKINO Yuichi 牧野 雄一

Research Projects

Research Products

Co-Researchers

Study on molecular mechanism underlying pulmonary hypertension and dysregulation of pulmonary vascular remodeling mediated by hypoxia-inducible transcription factorPrincipal Investigator

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Gene dysregulation by single nucleotide polymorphism of hypoxia-inducible transcription factor in molecular pathology of pulmonary hypertensionPrincipal Investigator

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Molecular pathology for IPAS/HIF-3a gene SNP-mediated pulmonary hypertension in connective tissue diseasePrincipal Investigator

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Role of IPAS/HIF-3alpha-mediated signals in the pathophysiology of pulmonary hypertension associated with connective tissue diseasePrincipal Investigator

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Elucidation of the regulatory mechanism for glucose-mediated pathogenic gene expression in diabetic nephropathy and its therapeutic application

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Role of hypoxia-inducible transcription factors in regulation of immune response and its therapeutic applicationPrincipal Investigator

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マイクロRNAによるNF-κB制御を介した関節リウマチ治療戦略に関する研究

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Mechanism of regulation of immune response by hypoxia-inducible factors and its therapeutic application to inflammatory diseasesPrincipal Investigator

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Strategise for treatment of rheumatoid synovitis on the focus of IκBβ2 expression.

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低酸素シグナル抑制分子IPASの発現制御法の開発とがん治療への応用Principal Investigator

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HIF-1拮抗分子IPASの発現制御機構の解明と抗血管新生療法開発への応用Principal Investigator

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Development of a novel therapy targeting the hypoxia response system in the immune cells for inflammatory diseases.Principal Investigator

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低酸素誘導性転写因子群を標的とする新規抗血管新生療法開発に関する研究Principal Investigator

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Makino Yuichi 牧野雄一

MAKINO Yuichi 牧野雄一

[Book] Hypoxia-inducible factor-1 (HIF-1)の発現制御からだと酸素の事典2009