Tankanezawa Yasukazu 高根沢康一

… Alternative Names

高根沢康一タカネザワヤスカズ

TAKANEZAWA Yasukazu 高根沢康一

Takanezawa Yasukazu 高根沢康一

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Researcher Number	90345257
Other IDs
Affiliation (Current)	2025: 北里大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 北里大学, 薬学部, 准教授 2018 – 2019: 北里大学, 薬学部, 准教授 2017: 北里大学, 薬学部, 講師 2014 – 2015: 北里大学, 薬学部, 講師 2006: 東京大学, 大学院薬学系研究科, 助手 2005: 東京大学, 大学院・薬学系研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Hygiene and public health / Environmental and hygienic pharmacy / Biological pharmacy Except Principal Investigator Environmental engineering and reduction of environmental burden / Functional biochemistry
Keywords	Principal Investigator メチル水銀 / オートファジー / p62/SQSTM1 / 微生物由来化合物ライブラリー / トランスポーター / プロテアソーム / p62 / 環境汚染物質 / 脳神経系変性疾患 / 重金属 … More / オレアノール酸配糖体 / パーキンソン病 / PUFA / 膜脂質 / 脂質プロファイル / ESI-MS / バイオマーカー / アルツハイマー病 / 脂質メタボローム … More Except Principal Investigator 環境技術 / 有害金属複合汚染浄化技術 / Mer輸送体 / メチル水銀 / 浄化植物 / 発現制御 / 金属輸送体 / 複合汚染 / 有害金属 / acvltransferase / fatty acid / phosnholinid / C. elegans / 脂肪酸転移酵素 / 脂肪酸 / リン脂質 / 線虫 Less

The autophagy cargo receptor p62 and its mechanistic roles in methylmercury detoxication.Principal Investigator
- Principal Investigator
  
  高根沢康一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Kitasato University
Analysis of toxic heavy metals in neurodegenerative disorders and evaluation of derivatives of oleanoic acid as a therapeutic candidatePrincipal Investigator
- Principal Investigator
  
  Yasukazu Takanezawa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  Kitasato University
Molecular breeding of Arabidopsis plants with cell-type specific promoters and a bacterial mercury transporter MerC
- Principal Investigator
  
  KIYONO MASAKO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental engineering and reduction of environmental burden
- Research Institution
  Kitasato University
Identification and characterization of methylmercy resposive proteins related to lipid compositionPrincipal Investigator
- Principal Investigator
  
  Takanezawa Yasukazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Kitasato University
脂質メタボローム解析を駆使したアルツハイマー病早期診断バイオマーカー脂質の探索Principal Investigator
- Principal Investigator
  
  高根沢康一
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
New approaches to functional elucidation of unknown genes related to lipid metabolism : combination of mutational approaches using C. elegans and metabolite analyses using mass spectrometry
- Principal Investigator
  
  ARAI Hiroyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2020 2019 2018 2017 2016 2015 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Proteasome and p62/SQSTM1 are involved in methylmercury toxicity mitigation in mouse embryonic fibroblast cells2023
- Author(s)
  Takanezawa Yasukazu、Nakamura Ryosuke、Ohshiro Yuka、Uraguchi Shimpei、Kiyono Masako
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 48 Issue: 6 Pages: 355-361
- DOI
  10.2131/jts.48.355
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12392
[Journal Article] Inhibition of p38 Mitogen-Activated Protein Kinases Attenuates Methylmercury Toxicity in SH-SY5Y Neuroblastoma Cells2023
- Author(s)
  Takanezawa Yasukazu、Sakai Kazuma、Nakamura Ryosuke、Ohshiro Yuka、Uraguchi Shimpei、Kiyono Masako
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 9 Pages: 1203-1210
- DOI
  10.1248/bpb.b23-00014
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-09-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12392
[Journal Article] Oleanolic acid 3-glucoside, a synthetic oleanane-type saponin, alleviates methylmercury toxicity in vitro and in vivo.2019
- Author(s)
  Nakamura R, Shirahata T, Konishi N, Takanezawa Y, Sone Y, Uraguchi S, Kobayashi Y, Kiyono M
- Journal Title
  
  Toxicology
  
  Volume: 1 Pages: 15-22
- DOI
  10.1016/j.tox.2019.02.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09164, KAKENHI-PROJECT-17K15468
[Journal Article] Oleanolic acid 3-(1’2’ ortoacetate- glucoside)-28- glucoside, alleviates methylmercury toxicity in vitro and in vivo.2019
- Author(s)
  Nakamura R, Shirahata T, Katsumi T, Konishi N, Takanezawa Y, Ohshiro Y, Uraguchi S, Kobayashi Y, Kiyono M.
- Journal Title
  
  BPB report
  
  Volume: 4 Pages: 56-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09164
[Journal Article] An autophagy deficiency promotes methylmercury-induced mutinuclear cell formation.2019
- Author(s)
  Takanezawa Y, Nakamura R, Sone Y, Uraguchi S, Kiyono M
- Journal Title
  
  Biochemical and Biophysical Research
  
  Volume: 2 Issue: 2 Pages: 460-467
- DOI
  10.1016/j.bbrc.2019.02.084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09164
[Journal Article] Docosahexaenoic acid enhances methylmercury-induced endoplasmic reticulum stress and cell death and eicosapentaenoic acid potentially attenuates these effects in mouse embryonic fibroblasts.2019
- Author(s)
  Takanezawa Y, Nakamura R, Hamaguchi M, Yamamoto K, Sone Y, Uraguchi S, Kiyono M
- Journal Title
  
  Toxicology Letters
  
  Volume: 15 Pages: 35-42
- DOI
  10.1016/j.toxlet.2019.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09164
[Journal Article] Cytochalasin E increased the sensitivity of human lung cancer A549 cells to bortezomib via inhibition of autophagy2018
- Author(s)
  Takanezawa Y, Nakamura R, Kojima Y, Sone Y, Uraguchi S, Kiyono M
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 498 Issue: 3 Pages: 603-608
- DOI
  10.1016/j.bbrc.2018.03.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15381, KAKENHI-PROJECT-17K09164
[Journal Article] Sequestosome1/p62 protects mouse embryonic fibroblasts against low-dose methylercury-induced cytotoxicity and is involved in clearance of ubiquitinated proteins.2017
- Author(s)
  Takanezawa Y, Nakamura R, Harada R, Sone Y, Uraguchi S, Kiyono M
- Journal Title
  
  Scientific reports
  
  Volume: 7 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-017-17112-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09164, KAKENHI-PROJECT-16K15381
[Journal Article] Cysteine and histidine residues are involved in Escherichia coli Tn21 MerE methylmercury transport.2017
- Author(s)
  Sone Y, Uraguchi S, Takanezawa Y, Nakamura R, Pan-Hou H, Kiyono M.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 7 Issue: 12 Pages: 1994-1999
- DOI
  10.1002/2211-5463.12341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02839, KAKENHI-PROJECT-15K18907
[Journal Article] A Novel Role of MerC in Methylmercury Transport and Phytoremediation of Methylmercury Contamination2017
- Author(s)
  Sone Y, Uraguchi S, Takanezawa Y, Nakamura R, Pan-Hou H, Kiyono M
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 7 Pages: 1125-1128
- DOI
  10.1248/bpb.b17-00213
- NAID
  130006846433
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02839, KAKENHI-PROJECT-15K18907
[Journal Article] 水銀トランスポーターを利用した水銀のファイトレメディエーション2015
- Author(s)
  清野正子、曽根有香、浦口晋平、中村亮介、高根沢康一、坂部貢
- Journal Title
  
  臨床環境医学
  
  Volume: 24 Pages: 71-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02839
[Journal Article] Type I platelet-activating factor acetylhydrolase catalytic subunit overexpression induces pleiomorphic nuclei and centrosome amplification2007
- Author(s)
  Yamaguchi N., Koizumi H., Aoki J., Natori Y., Nishikawa K., Natori Y., Takanezawa Y., Arai H.
- Journal Title
  
  Genes to Cells 12
  
  Pages: 1153-1161
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17207008
[Journal Article] Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction2007
- Author(s)
  Ohtsuki M, Taketomi Y, Arata S, Masuda S, Ishikawa Y, Ishii T, Takanezawa Y, Aoki J, Arai H, Yamamoto K, Kudo I, Murakami M.
- Journal Title
  
  J. Biol. Chem 281
  
  Pages: 36420-36433
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17207008
[Journal Article] Neuronal expression and neuritogenic action of group X secreted phospholipase A22005
- Author(s)
  Masuda S., Murakami M., Takanezawa Y., Aoki J., Arai H., Ishikawa Y., Ishii T., Arioka M., Kudo I.
- Journal Title
  
  J. Biol. Chem 280
  
  Pages: 23203-23214
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17207008
[Journal Article] Arai H. New approaches to functional elucidation of unknown genes related to lipid metabolism : combination of mutational approaches using C. elegans and metabolite analyses using mass spectrometry (Review)2005
- Author(s)
  Inoue T., Takanezawa Y.
- Journal Title
  
  Jikkenn Igaku 23
  
  Pages: 977-985
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17207008
[Journal Article] Group VIB Ca2+-independent phospholipase A2 (iPLA2γ) promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipase A2s2005
- Author(s)
  Murakami M., Masuda S., Ueda-Semmyo K., Yoda E., Kuwata, H. Takanezawa Y., Aoki J., Arai H., Sumimoto H., Ishikawa Y., Ishii T., Nakatani Y., Kudo I.
- Journal Title
  
  J. Biol. Chem 280
  
  Pages: 14028-14041
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17207008
[Presentation] メチル水銀毒性に対するオートファジーレセプターp62とNBR1の機能的差異に関する検証2024
- Author(s)
  高根沢康一，酒井和真, 中村亮介, 大城有香, 浦口晋平, 清野正子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K12392
[Presentation] p38MAPK阻害剤はSH-SY5Y細胞におけるメチル水銀毒性を緩和する2023
- Author(s)
  高根沢康一，酒井和真, 中村亮介, 大城有香, 浦口晋平, 清野正子
- Organizer
  フォーラム2023 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-22K12392
[Presentation] オートファジーレセプターp62によるメチル水銀毒性の制御2022
- Author(s)
  高根沢康一, 中村亮介, 大城有香, 浦口晋平, 清野正子
- Organizer
  メタルバイオサイエンス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K12392
[Presentation] メチル水銀毒性に対するオートファジーレセプターp62の細胞保護機構2022
- Author(s)
  高根沢康一, 清野正子
- Organizer
  フォーラム2022衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-22K12392
[Presentation] Dynamic weight bearing testを用いたMeHg毒性の評価2020
- Author(s)
  丹野真由香、中村亮介、高根沢康一、大城有香、浦口晋平、白畑辰弥、小西成樹、岩井孝志、小林義典、田辺光男、清野正子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] 低濃度メチル水銀に対するオートファジーおよびERストレス応答2019
- Author(s)
  高根沢康一、清野正子
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] メチル水銀による神経伝達障害に対するオレアノール酸 3-グルコシドの効果2019
- Author(s)
  中村亮介、高根沢康一、曽根有香、浦口晋平、白畑辰弥、岩井孝志、小林義典、田辺光男、清野正子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] 水銀トランスポーターMerCの金属選択性に関する研究2018
- Author(s)
  曽根有香、金子莉子、浦口晋平、中村亮介、高根沢康一、清野正子
- Organizer
  日本薬学会第１３８年会（金沢）
- Data Source
  KAKENHI-PROJECT-15H02839
[Presentation] メチル水銀応答における p62 と Nbr1 の発現解析2018
- Author(s)
  高根沢康一、原田遼平、中村亮介、曽根有香、浦口晋平、清野正子
- Organizer
  フォーラム2018　衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] メチル水銀毒性に対するオレアノール酸3位オルトエステル体の効果2018
- Author(s)
  中村亮介、高根沢康一、曽根有香、浦口晋平、白畑辰弥、小林義典、清野正子
- Organizer
  フォーラム2018　衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] メチル水銀の細胞毒性に対する高度不飽和脂肪酸（DHAとEPA）の影響2018
- Author(s)
  高根沢康一、中村亮介、曽根有香、浦口晋平、清野正子
- Organizer
  日本薬学会第139回
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] 表皮細胞特異的プロモーター制御下で水銀輸送体MerCを発現する植物の作出2018
- Author(s)
  清野正子、曽根有香、中村亮介、高根沢康一、浦口晋平
- Organizer
  日本薬学会第１３８年会（金沢）
- Data Source
  KAKENHI-PROJECT-15H02839
[Presentation] メチル水銀による神経伝達障害に対するオレアノール酸 3-グルコシドの効果2018
- Author(s)
  中村亮介、高根沢康一、曽根有香、浦口晋平、白畑辰弥、岩井孝志、小林義典、田辺光男、清野正子
- Organizer
  日本薬学会第139回
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] 植物の細胞型特異的プロモーターと微生物由来の金属輸送体MerCを用いたシロイヌナズナの分子育種2017
- Author(s)
  清野正子、曽根有香、中村亮介、高根沢康一、浦口晋平
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台国際会議場（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-15H02839
[Presentation] メチル水銀によるMAPキナーゼの活性化とオートファジー誘導2017
- Author(s)
  高根沢康一、原田遼平、中村亮介、曽根有香、浦口晋平、清野正子
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] Autophagy and sequestosome1/p62 play a protective role against low-dose methylmercury-induced cytotoxicity2017
- Author(s)
  Yasukazu Takanezawa, Ryosuke Nakamura, Yuka Sone, Shimpei Uraguchi, Masako Kiyono
- Organizer
  Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] オレアノール酸サポニン誘導体による抗メチル水銀活性の評価2017
- Author(s)
  中村亮介、高根沢康一、曽根有香、浦口晋平、白畑辰弥、小林義典、清野正子
- Organizer
  日本薬学会第138回
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] Molecular breeding of Arabidopsis plants with cell-type specific promoters and a bacterial mercury transporter MerC.2017
- Author(s)
  Kiyono M, Sone Y, Takanezawa Y, Nakamura R, Uraguchi S
- Organizer
  14th International Conference on the Biogeochemistry of Trace Elements
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02839
[Presentation] メチル水銀によるユビキチン結合タンパク質p62の発現誘導と防御機構の解析2017
- Author(s)
  原田遼平、高根沢康一、中村亮介、曽根有香、浦口晋平、清野正子
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] 水銀トランスポーターMerC, MerE, MerF, MerTのヒ素およびクロム輸送に関する研究2017
- Author(s)
  曽根有香、浦口晋平、中村亮介、高根沢康一、清野正子
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  仙台国際会議場（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-15H02839
[Presentation] Role of Mer in the transport of toxic metals in Escherichia coli.2017
- Author(s)
  Sone Y, Uraguchi S, Nakamura R, Takanezawa Y, Kiyono M
- Organizer
  FEMS 2017 7th Congress of European Microbiologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02839
[Presentation] 低濃度メチル水銀毒性防御におけるSquestosome1/p62の役割とユビキチン化タンパク質クリアランス2017
- Author(s)
  高根沢康一、原田遼平、中村亮介、曽根有香、浦口晋平、清野正子
- Organizer
  日本薬学会第138回
- Data Source
  KAKENHI-PROJECT-17K09164
[Presentation] p62の発現誘導とメチル水銀毒性防御機構の解析2016
- Author(s)
  高根沢康一、中村亮介、曽根有香、浦口晋平、清野正子
- Organizer
  136回日本薬学会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-26893043
[Presentation] 水銀トランスポーターMerC を利用したメチル水銀高蓄積性植物の作出2016
- Author(s)
  曽根有香、浦口晋平、中村亮介、高根沢康一、清野正子
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-15H02839
[Presentation] 細菌由来の水銀トランスポーターMerC, MerE, MerF, MerTの機能解析2015
- Author(s)
  曽根有香、中村亮介、高根沢康一、清野正子
- Organizer
  日本薬学会　第135年会
- Place of Presentation
  神戸(神戸サンボーホール)
- Year and Date
  2015-03-25
- Data Source
  KAKENHI-PROJECT-26893043
[Presentation] Bacterial heavy metal transporter MerC increases mercury accumulation in Arabidopsis thaliana.2015
- Author(s)
  Kiyono M, Sone Y, Takanezawa Y, Nakamura R, Uraguchi S
- Organizer
  13th International Conference on the Biogeochemistry of Trace Elements
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-07-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02839
[Presentation] Expression of the bacterial heavy metal transporter MerC fused with a plant SNARE in Arabidopsis thaliana increases mercury accumulation.2015
- Author(s)
  Kiyono M, Sone Y, Nakamura R, Takanezawa Y, Uraguchi S
- Organizer
  Pacifichem 2015
- Place of Presentation
  ハワイコンベンションセンター（アメリカ合衆国ハワイ州ホノルル）
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02839
[Presentation] Acl-10, an evolutionarily conserved acyltransferase, regulates muscle contraction in C. elegans2006
- Author(s)
  Rieko Imae, Takao Inoue, Naoko Hara, Yasukazu Takanezawa, Keiko Gengyo-Ando, Shohei Mitani, Hiroyuki Arai
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17207008
[Presentation] マウス腎臓におけるDHA含有リン脂質がエンドトキシンにより変化を起こす2005
- Author(s)
  高根沢康一
- Organizer
  日本生化学会
- Place of Presentation
  神戸
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17207008
[Presentation] メチル水銀ばく露による小胞体ストレスとオートファジー誘導
- Author(s)
  高根沢康一、中村亮介、曽根有香、内田龍児、供田洋、清野正子
- Organizer
  日本薬学会　第135年会
- Place of Presentation
  神戸(神戸サンボーホール)
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26893043
[Presentation] オレアノール酸およびその配糖体による抗メチル水銀作用に関する研究
- Author(s)
  中村亮介、曽根有香、高根沢康一、白畑辰弥、小林義典、清野正子
- Organizer
  日本薬学会　第135年会
- Place of Presentation
  神戸(神戸サンボーホール)
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26893043

1. ARAI Hiroyuki (40167987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. INOUE Takao (50361605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. KIYONO MASAKO (30239842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
4. URAGUCHI Shimpei (20638837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. SONE Yuka (60550035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. NAKAMURA Ryosuke (50383659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results

Tankanezawa Yasukazu 高根沢 康一

高根沢 康一 タカネザワ ヤスカズ

TAKANEZAWA Yasukazu 高根沢 康一

Takanezawa Yasukazu 高根沢 康一

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The autophagy cargo receptor p62 and its mechanistic roles in methylmercury detoxication.Principal Investigator

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Analysis of toxic heavy metals in neurodegenerative disorders and evaluation of derivatives of oleanoic acid as a therapeutic candidatePrincipal Investigator

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Molecular breeding of Arabidopsis plants with cell-type specific promoters and a bacterial mercury transporter MerC

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Identification and characterization of methylmercy resposive proteins related to lipid compositionPrincipal Investigator

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脂質メタボローム解析を駆使したアルツハイマー病早期診断バイオマーカー脂質の探索Principal Investigator

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New approaches to functional elucidation of unknown genes related to lipid metabolism : combination of mutational approaches using C. elegans and metabolite analyses using mass spectrometry

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[Journal Article] Proteasome and p62/SQSTM1 are involved in methylmercury toxicity mitigation in mouse embryonic fibroblast cells2023

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[Journal Article] Inhibition of p38 Mitogen-Activated Protein Kinases Attenuates Methylmercury Toxicity in SH-SY5Y Neuroblastoma Cells2023

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[Journal Article] Oleanolic acid 3-glucoside, a synthetic oleanane-type saponin, alleviates methylmercury toxicity in vitro and in vivo.2019

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[Journal Article] Oleanolic acid 3-(1’2’ ortoacetate- glucoside)-28- glucoside, alleviates methylmercury toxicity in vitro and in vivo.2019

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[Journal Article] An autophagy deficiency promotes methylmercury-induced mutinuclear cell formation.2019

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[Journal Article] Docosahexaenoic acid enhances methylmercury-induced endoplasmic reticulum stress and cell death and eicosapentaenoic acid potentially attenuates these effects in mouse embryonic fibroblasts.2019

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[Journal Article] Cytochalasin E increased the sensitivity of human lung cancer A549 cells to bortezomib via inhibition of autophagy2018

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Tankanezawa Yasukazu 高根沢康一

高根沢康一タカネザワヤスカズ

TAKANEZAWA Yasukazu 高根沢康一

Takanezawa Yasukazu 高根沢康一

[Presentation] メチル水銀毒性に対するオートファジーレセプターp62とNBR1の機能的差異に関する検証2024