Iemura Shun-ichiro 家村俊一郎

… Alternative Names

IEMURA Shun-ichiro 家村俊一郎

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Researcher Number	90356410
Other IDs
Affiliation (Current)	2025: 福島県立医科大学, 公私立大学の部局等, 教授
Affiliation (based on the past Project Information) *help	2013: 福島県立医科大学, 医療-産業TRセンー, 教授 2009: 独立行政法人産業技術総合研究所, バイオメディシナル情報研究センター, 主任研究員 2008: 独立行政法人産業技術総合研究所, バイオメディシナル情報研究センター, 主任研究員 2007: 産業技術総合研究所, バイオメデイシナル情報研究センター, 主任研究員 2006: 独立行政法人産業技術総合研究所, 生物情報解析研究センター, 主任研究員 2005: 独立行政法人産業技術総合研究所, 生物情報解析研究センター, 研究員
Review Section/Research Field	Except Principal Investigator Pathological medical chemistry / Biological Sciences
Keywords	Except Principal Investigator リン脂質 / 飢餓 / グルコース代謝 / 繊維状構造物 / 阻害剤 / 蛋白質 / ストレス / 胞・組織 / 酵素 / 緑内障 … More / 網膜色素変性症 / 細胞死 / ERストレス / VCP / ATPase / ATP / 安定同位体ラベル / Erkイフェクター / 古典的MAPキナーゼカスケ / ダイレクトナノLC / マップキナーゼカスケード / タンパク質問相互作用 / プロテミクス / Erk / シグナル伝達 / マップキナーゼカスケー / 動態解析 / 質量分析 / プロテオミクス / タンパク質ネットワーク解析 / タンパク質間相互作 Less

Analyses of the function and regulation of VCP, a major ATPase in the cells
- Principal Investigator
  
  KAKIZUKA Akira
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Quantitation analysis of pathway network analysis
- Principal Investigator
  
  NATSUME Tohru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2013 2010 2009 2008 2007 2006

All Journal Article

[Journal Article] VCP Is an Integral Component of a Novel Feedback Mechanism that Controls Intracellular Localization of Catalase and H2O2 Levels.2013
- Author(s)
  Murakami K, Ichinohe Y, Koike M, Sasaoka N, Iemura S, Natsume T, Kakizuka A.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 2 Pages: e56012-e56012
- DOI
  10.1371/journal.pone.0056012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249016
[Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap12010
- Author(s)
  Komatsu, M., H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, Y. Ichimura, Y.S. Sou, I. Ueno, A. Sakamoto, K.I. Tong, M. Kim, Y. Nishito, S.I. Iemura, T. Natsume, T. Ueno, E. Kominami, H. Motohashi, K. Tanaka, M. Yamamoto
- Journal Title
  
  Nat cell biology 12(3)
  
  Pages: 213-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] The novel thioredoxin-related transmembrane protein TMX4 has reductase activity.2010
- Author(s)
  Sugiura, Y., K.Araki, S.I.Iemura, T.Natsume, J.Hoseki, K.Nagata
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 7135-7142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.2010
- Author(s)
  Komatsu, M., H.Kurokawa, S.Waguri, K.Taguchi, A.Kobayashi, Y.Ichimura, Y.S.Sou, I.Ueno, A.Sakamoto, K.I.Tong, M.Kim, Y.Nishito, S.I.Iemura, T.Natsume, T.Ueno, E.Kominami, H.Motohashi, K.Tanaka, M.Yamamoto
- Journal Title
  
  Nat cell biology. 12
  
  Pages: 213-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Mys protein regulates protein kinase A activity by interacting with regutatory type 1{alpha} subunit during vertebrate development.2009
- Author(s)
  Kotani, T., S.I.Iemura, T.Natsume, K.Kawakami, M.Yamashita
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 5106-5116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.2009
- Author(s)
  Sagara M、Kawasaki Y、家村俊一郎、夏目徹、Takai Y、秋山徹(東京大学分子細胞生物学研究所)
- Journal Title
  
  Oncogene 28
  
  Pages: 1357-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] NLK, an essential effector of anterior formation, functions downstream of p38 MAP kinase.2009
- Author(s)
  Ohnishi, E., T.Goto, A.Sato, M.S.Kim, S.I.Iemura, T.Ishitani, T.Natsume, J.Ohnishi, H.Shibuyaup
- Journal Title
  
  Mol cell Biol. 30
  
  Pages: 675-683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones2009
- Author(s)
  Kaneko, T., J. Hamazaki, S. Iemura, K. Sasaki, K. Furuyama, T. Natsume, K. Tanaka, S. Murata
- Journal Title
  
  Cell 137(5)
  
  Pages: 914-925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.2009
- Author(s)
  Patrick, M.S., H.Oda, K.Hayakawa, Y.Sato, K.Eshima, T.Kirikae, S.Iemura, M.Shirai, T.Abe, T.Natsume, T.Sasazuki, H.Suzuki
- Journal Title
  
  Proc Natl Acad Sci USA 106
  
  Pages: 16345-16350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Inositol 1, 4, 5-triphosphate receptor-binding protein released with Inositol 1, 4, 5-triphosphate (IRBIT), associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.2009
- Author(s)
  Kiefer H、Mizutani A、家村俊一郎、夏目徹、Ando H、Kuroda Y、御子柴克彦((独)理化学研究所)
- Journal Title
  
  J Biol Chem 284
  
  Pages: 10694-10705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Ankyrin repeat domain 28 (ANKRD28), a novel binding partnerof DOCK180, promotes cell migration by regulating focal adhesion formation.2009
- Author(s)
  Tachibana M、Kiyokawa E、Hara S、家村俊一郎、夏目徹、Manabe T、松田道行(京都大学大学院生命科学研究科)
- Journal Title
  
  Exp Cell Res 315
  
  Pages: 863-876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A novel type of E3-ligase for the Ufm1-conjugation system.2009
- Author(s)
  Tatsumi, K., Y.S.Sou, N.Tada, E.Nakamura, S.I.Iemura, T.Natsume, S.H.Kang, C.H.Chung, M.Kasahara, E.Kominami, M.Yamamoto, K.Tanaka, M.Komatsu
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 5417-5427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy.2009
- Author(s)
  Hosokawa N、Hara T、Kaizuka T、Kishi C、Takamura A、Miura Y、家村俊一郎、夏目徹、Takehana K、Yamada N、Guan JL、Oshiro N、水島昇(東京医科歯科大学私学総合研究科)
- Journal Title
  
  Mol Biol Cell 20
  
  Pages: 1981-1991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis2009
- Author(s)
  Nishiyama, M., K. Oshikawa, Y. Tsukada, T. Nakagawa, S. Iemura, T. Natsume, Y. Fan, A. Kikuchi, A.I. Skoultchi, K.I. Nakayama
- Journal Title
  
  Nat cell biology 11(2)
  
  Pages: 863-876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.2009
- Author(s)
  Nishiyama M、Oshikawa K、Tsukada Y、Nakagawa T、家村俊一郎、夏目徹、Fan Y、Kikuchi A、Skoultchi AI、中山敬一(九州大学生態防御医学研究所)
- Journal Title
  
  Nat Cell Biol 11
  
  Pages: 863-876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] FIP200, a ULK-interacting protein, is required for autophago some formation in mammalian cells.2008
- Author(s)
  Hara T, Takanlura A, Kishi C, 家村俊一郎, 夏目徹, Guan JL, Mizushima N.
- Journal Title
  
  J Cell Biol. 181
  
  Pages: 497-510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A parallel affinity purification method for selective isolation of polyubiquitinated proteins.2008
- Author(s)
  伊藤隆司(東京大学)、夏目徹、家村俊一郎、太田一寿(東京大学)、紀藤圭治(東京大学)
- Journal Title
  
  Proteomics 8
  
  Pages: 3004-3007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells2008
- Author(s)
  Hara, T., A. Takamura, C. Kishi, S. Iemura, T. Natsume, J.L. Guan, N. Mizushima
- Journal Title
  
  The Journal of cell biology 181(3)
  
  Pages: 497-510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] CAATT/enhancer-binding proteins alpha and delta interact wit h NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression.2008
- Author(s)
  Takeshi Tomita(National Institutes of Health)、夏目徹、家村俊一郎、Taketomo Kido(National Institutes of Health)、黒谷玲子(横浜市立大学)、Esta Sterneck(National Institutes of Health)、Charles Vinson(National Institutes of Health)、Shioko Kimura(National Institutes of Health)
- Journal Title
  
  J Biol Chem 283
  
  Pages: 25617-25627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport.2008
- Author(s)
  原重雄(大阪大学)、夏目徹、家村俊一郎、松田道行(京都大学)、清川悦子(京都大学)、Thomas Wassmer(University of Bristol)、Peter J. Cullen (University of Bristol)、日合弘(滋賀県立成人病センター)
- Journal Title
  
  J Biol Chem 19
  
  Pages: 3823-3835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Nucleo-cytoplasmic shuttling of the zinc finger protein EZI is mediatedby importin-Independent nuclear import and CRMl-independent exportmechanisms2007
- Author(s)
  Saijou E, Itoh T, Kim KW, Iemura SI, Natsume T, Miyajima A.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 32327-32337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice2007
- Author(s)
  Komatsu, M., S. Waguri, M. Koike, Y.S. Sou, T. Ueno, T. Hara, N. Mizushima, J. Iwata, J. Ezaki, S. Murata, J. Hamazaki, Y. Nishito, S. Iemura, T. Natsume, T. Yanagawa, J. Uwayama, E. Warabi, H. Yoshida, T. Ishii, A. Kobayashi, M. Yamamoto, Z. Yue, Y. Uchiyama, E. Kominami, K. Tanaka
- Journal Title
  
  Cell 131(6)
  
  Pages: 1149-1163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Nemo-Like Kinase-Myocyte Enhancer Factor 2A Signaling Regulates Anterior Formation in Xenopus Development2007
- Author(s)
  Satoh K, Ohnishi J, Sato A, Takeyama M, Iemura S, Natsume T, Shibuya H.
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 7623-7630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility2007
- Author(s)
  Iioka, H., S. Iemura, T. Natsume, N. Kinoshita
- Journal Title
  
  Nat cell biology 9(7)
  
  Pages: 813-821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway2007
- Author(s)
  Lee, R.H., H. Iioka, M. Ohashi, S. Iemura, T. Natsume, N. Kinoshita
- Journal Title
  
  The EMBO journal 26(15)
  
  Pages: 3592-3606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Anchoring of the 26S proteasome to the organellar membrane by FKBP382007
- Author(s)
  Nakagawa T, Shirane M, Iemura S, Natsume T, Nakayama KI.
- Journal Title
  
  Genes Cells 12
  
  Pages: 709-719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] XRab40 and XCullin5 form aubiquitin ligase complex essential for the noncanonical Wnt pathway2007
- Author(s)
  Lee RH, Iioka H, Ohashi M, Iemura S, Natsume T, Kinoshita N.
- Journal Title
  
  EMBO J 26
  
  Pages: 3592-3606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility2007
- Author(s)
  Iioka H, Iemura S, Natsume T, Kinoshita N.
- Journal Title
  
  Nat Cell Biol 9
  
  Pages: 813-821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes2006
- Author(s)
  Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., Murata, S.
- Journal Title
  
  The EMBO journal 25(19)
  
  Pages: 4524-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.2006
- Author(s)
  Hamazaki J, Iemura S, Natsume T, Yashiroda H, Tanaka K, Murata S
- Journal Title
  
  EMBO J 25 (19)
  
  Pages: 4524-4536
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy2006
- Author(s)
  Hishiya, A., Iemura, S., Natsume, T., Takayama, S., Ikeda, K., Watanabe, K.
- Journal Title
  
  Embo J 25(3)
  
  Pages: 554-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Shugoshin collaborates with protein phosphatase 2A to protect cohesin2006
- Author(s)
  Kitajima, T.S., Sakuno, T., Ishiguro, K., Iemura, S., Natsume, T., Kawashima, S.A., Watanabe, Y.
- Journal Title
  
  Nature 441(7089)
  
  Pages: 46-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation2006
- Author(s)
  Hyodo-Miura, J., Yamamoto, T.S., Hyodo, A.C., Iemura, S., Kusakabe, M., Nishida, E., Natsume, T., Ueno, N.
- Journal Title
  
  Dev Cell 11(1)
  
  Pages: 69-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Cooperation of Multiple Chaperones Required for the Assembly of Mammalian 20S Proteasomes.2006
- Author(s)
  Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S
- Journal Title
  
  Mol Cell. 24 (6)
  
  Pages: 977-984
- Data Source
  KAKENHI-PROJECT-17017042
[Journal Article] Protein phosphatase 6 down-regulates TAKI kinase activation in the IL-1 signaling pathway.2006
- Author(s)
  Kaj ino T, Ren H, Iemura S, Natsume T, Stefansson B, Brautigan DL, Matsumoto K, Ninomiya-Tsuji J
- Journal Title
  
  J Biol Chem. 281 (52)
  
  Pages: 39891-39896
- Data Source
  KAKENHI-PROJECT-17017042

1. NATSUME Tohru (00357683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 34 results
2. NAKAYAMA hiroshi (80321793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. SHIBUYA Kohji (30261324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. KAKIZUKA Akira (80204329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. IKEDA Hanako (20372162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IMAMURA Hiromi (20422545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Iemura Shun-ichiro 家村 俊一郎

IEMURA Shun-ichiro 家村 俊一郎

Research Projects

Research Products

Co-Researchers

Analyses of the function and regulation of VCP, a major ATPase in the cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitation analysis of pathway network analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] VCP Is an Integral Component of a Novel Feedback Mechanism that Controls Intracellular Localization of Catalase and H2O2 Levels.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap12010

Author(s)

Journal Title

Data Source

[Journal Article] The novel thioredoxin-related transmembrane protein TMX4 has reductase activity.2010

Author(s)

Journal Title

Data Source

[Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.2010

Author(s)

Journal Title

Data Source

[Journal Article] Mys protein regulates protein kinase A activity by interacting with regutatory type 1{alpha} subunit during vertebrate development.2009

Author(s)

Journal Title

Data Source

[Journal Article] Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.2009

Author(s)

Journal Title

Data Source

[Journal Article] NLK, an essential effector of anterior formation, functions downstream of p38 MAP kinase.2009

Author(s)

Journal Title

Data Source

[Journal Article] Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones2009

Author(s)

Journal Title

Data Source

[Journal Article] Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.2009

Author(s)

Journal Title

Data Source

[Journal Article] Inositol 1, 4, 5-triphosphate receptor-binding protein released with Inositol 1, 4, 5-triphosphate (IRBIT), associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.2009

Author(s)

Journal Title

Data Source

[Journal Article] Ankyrin repeat domain 28 (ANKRD28), a novel binding partnerof DOCK180, promotes cell migration by regulating focal adhesion formation.2009

Author(s)

Journal Title

Data Source

[Journal Article] A novel type of E3-ligase for the Ufm1-conjugation system.2009

Author(s)

Journal Title

Data Source

[Journal Article] Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy.2009

Author(s)

Journal Title

Data Source

[Journal Article] CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis2009

Author(s)

Journal Title

Data Source

[Journal Article] CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.2009

Author(s)

Journal Title

Data Source

[Journal Article] FIP200, a ULK-interacting protein, is required for autophago some formation in mammalian cells.2008

Author(s)

Iemura Shun-ichiro 家村俊一郎

IEMURA Shun-ichiro 家村俊一郎