HAMAMOTO HIROSHI 浜本洋

… Alternative Names

HAMAMOTO Hiroshi 浜本洋

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Researcher Number	90361609
Other IDs
Affiliation (Current)	2026: 山形大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2026: 山形大学, 医学部, 教授 2023 – 2024: 山形大学, 医学部, 教授 2021 – 2023: 帝京大学, 付置研究所, 准教授 2016 – 2021: 帝京大学, 医真菌研究センター, 准教授 2015: 東京大学, 大学院薬学系研究科(薬学部), 助教 … More 2011 – 2015: 東京大学, 薬学研究科(研究院), 助教 2013: 東京大学, 大学院薬学系研究科, 助教 2012: 東京大学, 大学院・薬学系研究科, 助教 2009 – 2010: The University of Tokyo, 大学院・薬学系研究科, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Basic Section 54030:Infectious disease medicine-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Natural medicines / Science and Engineering / Environmental pharmacy / Medical pharmacy / Biological pharmacy Except Principal Investigator Basic Section 57020:Oral pathobiological science-related / Basic Section 49050:Bacteriology-related / Environmental and hygienic pharmacy / Drug development chemistry
Keywords	Principal Investigator カイコ / 感染症 / 抗生物質 / 新規抗生物質 / 作用機序解析 / 黄色ブドウ球菌 / ケミカルバイオロジー / バイオフィルム / AMR対策 / 感染症治療薬 … More / 電子伝達系 / 超短時間作用性殺菌化合物 / 探索 / 宿主 / 化学療法薬 / 分子生物学 / 生化学 / 微生物と宿主の相互作用 / 化学療法学 / lipid II / アポリポプロテインA-I / ライソシンE / 宿主と微生物の相互作用 / 化合物ライブラリー / 抗菌薬 / 応用微生物 / 次世代シークセンサー / 微生物 / シトクロームP450 / シトクローム P450 / 薬物動態 / 細菌感染 / サイトカイン / 自然免疫応答 / シグナル伝達 / 昆虫サイトカイン / 麻痺ペプチド / 自然免疫 … More Except Principal Investigator カイコ / 細菌 / 歯周病 / 歯周病細菌 / 微生物 / 感染症 / 輸送機構 / リポタンパク質 / 線毛 / タンパク質分泌機構 / 歯周病原菌 / カイコ創薬 / primed immune response / 創薬 / マウス感染モデル / カイコ感染モデル / 緑膿菌 / 乳酸菌Weissella hellenica / 緑膿菌感染症 / ペプチドグリカン / 新規天然物 / 乳酸菌 / 食品 / 自然免疫 / 発現制御 / 発現抑制 / ncRNA / 抗菌薬 / 発現解析 / 薬学 / 阻害薬 / 遺伝子機能解析 / 網羅的遺伝子発現解析 / 病原性 / 抗真菌剤 / 体内動態 / 動物モデル / 真菌 Less

メナキノンに着目した抗菌薬の殺菌作用の解明とより効果が高い併用療法の確立Principal Investigator
- Principal Investigator
  
  浜本洋
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Yamagata University
Elucidation of the bactericidal mechanism involving menaquinone induction in novel antimicrobial therapeutics.Principal Investigator
- Principal Investigator
  
  浜本洋
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Yamagata University
Mechanstic analysis of Lysosin E for Staphylococcus aureus biofilm infectionPrincipal Investigator
- Principal Investigator
  
  浜本洋
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Yamagata University
歯周病原細菌の9型分泌機構における選択的分泌メカニズムの解明
- Principal Investigator
  
  庄子幹郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Nagasaki University
Elucidation of the lipoprotein transport mechanism specific to Bacteroidia bacteria such as periodontal pathogens
- Principal Investigator
  
  Yukitake Hideharu
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Nagasaki University
Functional analysis of novel substances from food materials showing strong abilities of innate immunity stimulation
- Principal Investigator
  
  Sekimizu Kazuhisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Teikyo University
Mechanism of action analysis of novel antibiotics in host factor contribution to therapeutic efficacyPrincipal Investigator
- Principal Investigator
  
  Hiroshi Hamamoto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Teikyo University
Platform for the identification of novel therapeutically effective antimicrobial agents
- Principal Investigator
  
  Kazuhisa Sekimizu
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Teikyo University
  The University of Tokyo
新規抗生物質カイコシンと、宿主由来活性促進因子との相互作用解析Principal Investigator
- Principal Investigator
  
  浜本洋
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Development of lead commands for new anti-infective agentsPrincipal Investigator
- Principal Investigator
  
  HAMAMOTO Hiroshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Natural medicines
- Research Institution
  The University of Tokyo
Establishment of screening system for antifungal drugs using silkworm fungus infection model
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Establishment of a screening system for therapeutically effective antibioticsPrincipal Investigator
- Principal Investigator
  
  HAMAMOTO Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Environmental pharmacy
- Research Institution
  The University of Tokyo
Evaluation of pharmacokinetic using silkworm as an animal modelPrincipal Investigator
- Principal Investigator
  
  HAMAMOTO Hiroshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Activation mechanism and functional analysis of insect cytokine PP on innate immune responsePrincipal Investigator
- Principal Investigator
  
  HAMAMOTO Hiroshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

[Journal Article] Noncontiguous operon atlas for the Staphylococcus aureus genome2024
- Author(s)
  Iturbe Pablo、Martin Alvaro San、Hamamoto Hiroshi、Marcet-Houben Marina、Galbald?n Toni、Solano Cristina、Lasa Inigo
- Journal Title
  
  microLife
  
  Volume: 5
- DOI
  10.1093/femsml/uqae007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27410
[Journal Article] Development of next-generation antimicrobials with unique mechanisms of action2024
- Author(s)
  HAMAMOTO Hiroshi
- Journal Title
  
  Nippon Saikingaku Zasshi
  
  Volume: 79 Issue: 3 Pages: 275-281
- DOI
  10.3412/jsb.79.275
- ISSN
  0021-4930, 1882-4110
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-23K27410, KAKENHI-PROJECT-24KF0177
[Journal Article] Silkworm model of bacterial infection facilitates the identification of lysocin E, a potent, ultra-rapid bactericidal antibiotic2024
- Author(s)
  Hamamoto Hiroshi
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 77 Issue: 8 Pages: 477-485
- DOI
  10.1038/s41429-024-00739-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27410
[Journal Article] Molecular Editing Enhances Oxidation Resistance of Menaquinone‐Targeting Antibiotics Lysocin E and WAP‐8294A22023
- Author(s)
  Junhao Fu, Yosuke Nakata, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 29 Issue: 47
- DOI
  10.1002/chem.202301224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05286, KAKENHI-PLANNED-23H04889, KAKENHI-PROJECT-22H04970, KAKENHI-PROJECT-21H02733, KAKENHI-PROJECT-23K27410
[Journal Article] Construction of Five Tryptophan Isomers and Application of the Isomers to Solid‐Phase Total Syntheses of Lysocin E Derivatives2023
- Author(s)
  Yosuke Nakata, Junhao Fu, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 29 Issue: 43
- DOI
  10.1002/chem.202301225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05286, KAKENHI-PLANNED-23H04889, KAKENHI-PROJECT-22H04970, KAKENHI-PROJECT-21H02733, KAKENHI-PROJECT-23K27410
[Journal Article] Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs.2022
- Author(s)
  Geberetsadik G, Inaizumi A, Nishiyama A, Yamaguchi T, Hamamoto H, Panthee S, Tamaru A, Hayatsu M, Mizutani Y, Kaboso SA, Hakamata M, Ilinov A, Ozeki Y, Tateishi Y, Sekimizu K, Matsumoto S.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 66 Issue: 9
- DOI
  10.1128/aac.00171-22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19637, KAKENHI-PROJECT-19K16651, KAKENHI-PROJECT-20KK0216, KAKENHI-PROJECT-23K24374, KAKENHI-PROJECT-21H02733
[Journal Article] Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret2022
- Author(s)
 Hiroshi Hamamoto,Atsushi Miyashita,Koushirou Kamura,Ryo Horie,Kazuhisa Sekimizu
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 16 Issue: 6 Pages: 280-285
- DOI
 10.5582/ddt.2022.01088
- ISSN
 1881-7831, 1881-784X
- Year and Date
 2022-12-25
- Language
 English
- Open Access
- Data Source
 KAKENHI-PROJECT-21H02733
[Journal Article] Applying the silkworm model for the search of immunosuppressants2021
- Author(s)
  Miyashita Atsushi、Hamamoto Hiroshi、Sekimizu Kazuhisa
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 15 Issue: 3 Pages: 139-142
- DOI
  10.5582/ddt.2021.01041
- NAID
  130008062690
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2021-06-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07140
[Journal Article] A novel application of bubble-eye strain of Carassius auratus for ex vivo fish immunological studies2021
- Author(s)
  Nakajima Hiroto、Miyashita Atsushi、Hamamoto Hiroshi、Sekimizu Kazuhisa
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 10757-10757
- DOI
  10.1038/s41598-021-89882-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07140
[Journal Article] An efficient method to screen for the soil bacteria producing therapeutically effective antibiotics2021
- Author(s)
  Hamamoto Hiroshi、Panthee Suresh、Hashimoto Kana、Tsuchida Toshio、Sekimizu Kazuhisa
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 74 Issue: 12 Pages: 850-855
- DOI
  10.1038/s41429-021-00476-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07140
[Journal Article] Evaluation of pathogenicity and therapeutic effectiveness of antibiotics using silkworm Nocardia infection model2021
- Author(s)
 Mikami Kazuhiro、Sonobe Kazunari、Ishino Keiko、Noda Takumi、Kato Mami、Hanao Mami、Hamamoto Hiroshi、Sekimizu Kazuhisa、Okazaki Mitsuhiro
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 15 Issue: 2 Pages: 73-77
- DOI
 10.5582/ddt.2021.01035
- NAID
 130008037117
- ISSN
 1881-7831, 1881-784X
- Year and Date
 2021-04-30
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-20K07836
[Journal Article] YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus2021
- Author(s)
  Paudel Atmika、Panthee Suresh、Hamamoto Hiroshi、Grunert Tom、Sekimizu Kazuhisa
- Journal Title
  
  Virulence
  
  Volume: 12 Issue: 1 Pages: 470-480
- DOI
  10.1080/21505594.2021.1875683
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-19K16653
[Journal Article] Complete genome sequence and comparative genomic analysis of Enterococcus faecalis EF-2001, a probiotic bacterium2021
- Author(s)
  Panthee Suresh、Paudel Atmika、Hamamoto Hiroshi、Ogasawara Akihiko Ano、Iwasa Toshihiro、Blom Jochen、Sekimizu Kazuhisa
- Journal Title
  
  Genomics
  
  Volume: 113 Issue: 3 Pages: 1534-1542
- DOI
  10.1016/j.ygeno.2021.03.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-19K16653
[Journal Article] Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model2021
- Author(s)
  Panthee Suresh、Hamamoto Hiroshi、Nishiyama Yayoi、Paudel Atmika、Sekimizu Kazuhisa
- Journal Title
  
  Journal of Fungi
  
  Volume: 7 Issue: 11 Pages: 995-995
- DOI
  10.3390/jof7110995
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-19K16653
[Journal Article] Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus2021
- Author(s)
  Hiroshi Hamamoto*, Suresh Panthee*, Atmika Paudel, Kenichi Ishii, Jyunichiro Yasukawa, Su Jie, Atsushi Miyashita, Hiroaki Itoh, Kotaro Tokumoto, Masayuki Inoue, Kazuhisa Sekimizu
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 6364-6364
- DOI
  10.1038/s41467-021-26702-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06456, KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-19K16653, KAKENHI-ORGANIZER-16H06455, KAKENHI-WRAPUP-21H00457, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-21K05286
[Journal Article] A simple artificial diet available for research of silkworm disease models2020
- Author(s)
  Paudel Atmika、Panthee Suresh、Hamamoto Hiroshi、Sekimizu Kazuhisa
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 14 Issue: 4 Pages: 177-180
- DOI
  10.5582/ddt.2020.03061
- NAID
  130007897980
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2020-08-31
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-19K16653
[Journal Article] Development of an in vivo-mimic silkworm infection model with Mycobacterium avium complex2020
- Author(s)
 Yagi Akiho、Yamazaki Hiroyuki、Terahara Takeshi、Yang Taehui、Hamamoto Hiroshi、Imada Chiaki、Tomoda Hiroshi、Uchida Ryuji
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 14 Issue: 6 Pages: 287-295
- DOI
 10.5582/ddt.2020.03099
- NAID
 130007974226
- ISSN
 1881-7831, 1881-784X
- Year and Date
 2020-12-31
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-19J15511
[Journal Article] Large-Scale Screening and Identification of Novel Pathogenic Staphylococcus aureus Genes Using a Silkworm Infection Model2020
- Author(s)
  Paudel Atmika、Hamamoto Hiroshi、Panthee Suresh、Matsumoto Yasuhiko、Sekimizu Kazuhisa
- Journal Title
  
  The Journal of Infectious Diseases
  
  Volume: - Issue: 11 Pages: 1795-1804
- DOI
  10.1093/infdis/jiaa004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-19K16653
[Journal Article] The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus2020
- Author(s)
  Panthee Suresh、Paudel Atmika、Hamamoto Hiroshi、Uhlemann Anne-Catrin、Sekimizu Kazuhisa
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 11 Pages: 2076-2076
- DOI
  10.3389/fmicb.2020.02076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-19K16653
[Journal Article] Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library2020
- Author(s)
  Takada Yuri、Itoh Hiroaki、Paudel Atmika、Panthee Suresh、Hamamoto Hiroshi、Sekimizu Kazuhisa、Inoue Masayuki
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4935-4935
- DOI
  10.1038/s41467-020-18711-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-19K16653, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-19K15704
[Journal Article] Pharmacokinetics of anti-infectious reagents in silkworms2019
- Author(s)
  Hamamoto Hiroshi、Horie Ryo、Sekimizu Kazuhisa
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 9451-9451
- DOI
  10.1038/s41598-019-46013-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-15H05783
[Journal Article] Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E2019
- Author(s)
  Hiroaki Itoh, Kotaro Tokumoto, Takuya Kaji, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 2992-2992
- DOI
  10.1038/s41467-019-10754-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15704, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-19K16653
[Journal Article] Molecular characterization of multi-drug resistant coagulase negative cocci in non-hospital environment2019
- Author(s)
  Nwibo Daniel Don、Panthee Suresh、Hamamoto Hiroshi、Sekimizu Kazuhisa
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 13 Issue: 3 Pages: 145-149
- DOI
  10.5582/ddt.2019.01031
- NAID
  130007682088
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2019-06-30
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-17F17421
[Journal Article] Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis2019
- Author(s)
  Panthee Suresh、Paudel Atmika、Blom Jochen、Hamamoto Hiroshi、Sekimizu Kazuhisa
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 10 Pages: 1619-1619
- DOI
  10.3389/fmicb.2019.01619
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-17F17421, KAKENHI-PROJECT-19K16653
[Journal Article] Streptococcus pyogenes transcriptome changes in the inflammatory environment of necrotizing fasciitis.2019
- Author(s)
  Hirose Y, Yamaguchi M, Okuzaki D, Motooka D, Hamamoto H, Hanada T, Sumitomo T, Nakata M, Kawabata S.
- Journal Title
  
  Appl Environ Microbiol
  
  Volume: 85 Issue: 21
- DOI
  10.1128/aem.01428-19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11958, KAKENHI-PROJECT-19K22710, KAKENHI-PROJECT-19K22715, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-16H05847, KAKENHI-PROJECT-17H04369, KAKENHI-PROJECT-17H05103, KAKENHI-PROJECT-17K11610, KAKENHI-PROJECT-17K11666, KAKENHI-PROJECT-18K19643, KAKENHI-PROJECT-15KK0306, KAKENHI-PROJECT-19H03825
[Journal Article] GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus2019
- Author(s)
  Paudel Atmika、Panthee Suresh、Hamamoto Hiroshi、Sekimizu Kazuhisa
- Journal Title
  
  RSC Advances
  
  Volume: 9 Issue: 65 Pages: 37889-37894
- DOI
  10.1039/c9ra06844a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07140, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-19K16653
[Journal Article] Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model2018
- Author(s)
  Paudel Atmika、Panthee Suresh、Urai Makoto、Hamamoto Hiroshi、Ohwada Tomohiko、Sekimizu Kazuhisa
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1578-1578
- DOI
  10.1038/s41598-018-19867-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 17682018
- Author(s)
  Panthee Suresh、Hamamoto Hiroshi、Ishijima Sanae A、Paudel Atmika、Sekimizu Kazuhisa
- Journal Title
  
  Genome Biology and Evolution
  
  Volume: 10 Issue: 8 Pages: 2017-2022
- DOI
  10.1093/gbe/evy166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-17F17421, KAKENHI-PROJECT-16K08790
[Journal Article] Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection.2017
- Author(s)
  Nakamura, I., Kanasaki, R., Yoshikawa, K., Furukawa, S., Fujie, A., Hamamoto, H., and Sekimizu, K.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 70 Issue: 1 Pages: 41-44
- DOI
  10.1038/ja.2016.106
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Genomic analysis of vancomycin-resistant Staphylococcus aureus VRS3b and its comparison with other VRSA isolates2017
- Author(s)
 Panthee S, Hamamoto H, Paudel A, Sekimizu K
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 11 Issue: 2 Pages: 78-83
- DOI
 10.5582/ddt.2017.01024
- NAID
 130007040198
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15H05783
[Journal Article] In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-52017
- Author(s)
  Panthee, S., Hamamoto, H., Suzuki, Y., and Sekimizu, K.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 70 Issue: 2 Pages: 204-207
- DOI
  10.1038/ja.2016.102
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b2017
- Author(s)
  Panthee S, Paudel A, Hamamoto H, Sekimizu K
- Journal Title
  
  Genome Announc
  
  Volume: 5 Issue: 22
- DOI
  10.1128/genomea.00452-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Influence of clove oil and eugenol on muscle contraction of silkworm (Bombyx mori)2017
- Author(s)
 Kheawfu K, Pikulkaew S, Hamamoto H, Sekimizu K, Okonogi S
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 11 Issue: 2 Pages: 64-69
- DOI
 10.5582/ddt.2017.01012
- NAID
 130007040200
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-15H05783
[Journal Article] Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from Rhizobium sp. strain M2 screened using a silkworm muscle contraction assay2017
- Author(s)
 Urai Makoto、Aizawa Tomoko、Imamura Katsutoshi、Hamamoto Hiroshi、Sekimizu Kazuhisa
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 11 Issue: 5 Pages: 238-245
- DOI
 10.5582/ddt.2017.01045
- NAID
 130006210838
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-15J04318, KAKENHI-PROJECT-15K07923
[Journal Article] In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms.2017
- Author(s)
  Anantaworasakul, P., Hamamoto, H., Sekimizu, K., and Okonogi, S.
- Journal Title
  
  Pharm Biol
  
  Volume: 55 Issue: 1 Pages: 1256-1262
- DOI
  10.1080/13880209.2017.1297467
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Unified Total Synthesis of Polyoxins?J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions2017
- Author(s)
  Fujino Haruka、Nagatomo Masanori、Paudel Atmika、Panthee Suresh、Hamamoto Hiroshi、Sekimizu Kazuhisa、Inoue Masayuki
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 56 Issue: 39 Pages: 11865-11869
- DOI
  10.1002/anie.201706671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08156, KAKENHI-PLANNED-17H06452, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-17J09814
[Journal Article] Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic2017
- Author(s)
  Hiroaki Itoh, Kotaro Tokumoto, Takuya Kaji, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 印刷中 Issue: 13 Pages: 6924-6935
- DOI
  10.1021/acs.joc.7b02318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15421, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-16J08733
[Journal Article] Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis2017
- Author(s)
  Yagi Akiho、Uchida Ryuji、Hamamoto Hiroshi、Sekimizu Kazuhisa、Kimura Ken-ichi、Tomoda Hiroshi
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 70 Issue: 5 Pages: 685-690
- DOI
  10.1038/ja.2017.23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-16H05095
[Journal Article] A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus2017
- Author(s)
  Paudel Atmika、Hamamoto Hiroshi、Panthee Suresh、Kaneko Keiichi、Matsunaga Shigeki、Kanai Motomu、Suzuki Yutaka、Sekimizu Kazuhisa
- Journal Title
  
  Front Microbiol
  
  Volume: 8 Pages: 712-712
- DOI
  10.3389/fmicb.2017.00712
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract2017
- Author(s)
 Anantaworasakul P、Hamamoto H、Sekimizu K、Okonogi S
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 11 Issue: 2 Pages: 70-77
- DOI
 10.5582/ddt.2017.01013
- NAID
 130007040199
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-15H05783
[Journal Article] Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents2017
- Author(s)
  Panthee, S., Paudel, A., Hamamoto, H., and Sekimizu, K.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 8
- DOI
  10.3389/fmicb.2017.00373
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Identification of lysocin E using a silkworm model of bacterial infection2016
- Author(s)
  Hamamoto, H. Sekimizu, K.
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 10 Issue: 1 Pages: 24-29
- DOI
  10.5582/ddt.2016.01012
- NAID
  130005133325
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26102714, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-26670043
[Journal Article] Menaquinone as a potential target of antibacterial agents2016
- Author(s)
  Paudel, A., Hamamoto, H., Panthee, S., and Sekimizu, K.
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 10 Issue: 3 Pages: 123-128
- DOI
  10.5582/ddt.2016.01041
- NAID
  130005167357
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Using silkworms as a laboratory animal to evaluate medicines and foods2016
- Author(s)
  Sekimizu, K. Hamamoto, H.
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 10 Issue: 1 Pages: 1-2
- DOI
  10.5582/ddt.2016.01018
- NAID
  130005133320
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity2016
- Author(s)
  T. Kaji, M. Murai, H. Itoh, J. Yasukawa, H. Hamamoto, K. Sekimizu, M. Inoue
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 22 Issue: 47 Pages: 16912-16919
- DOI
  10.1002/chem.201604022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01130, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-15H06156, KAKENHI-PROJECT-16J08733
[Journal Article] A silkworm infection model to investigate Vibrio vulnificus virulence genes2016
- Author(s)
  Yamamoto, M., Kashimoto, T., Yoshimura, Y., Tachibana, N., Kuroda, S., Miki, Y., Kitabayashi, S., Tong, P., Xiao, J., Tanaka, K., Hamamoto, H., Sekimizu, K., and Yamamoto, K.
- Journal Title
  
  Mol Med Rep
  
  Volume: 14 Issue: 5 Pages: 4243-4247
- DOI
  10.3892/mmr.2016.5782
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-26850087, KAKENHI-PROJECT-16K00655
[Journal Article] Lysobacter species: a potential source of novel antibiotics.2016
- Author(s)
  Panthee, S., Hamamoto, H., Paudel, A., and Sekimizu, K.
- Journal Title
  
  Archives of microbiology
  
  Volume: 9 Issue: 9 Pages: 839-845
- DOI
  10.1007/s00203-016-1278-5
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] カイコモデルを用いた治療効果を示す化合物の探索2016
- Author(s)
  浜本洋
- Journal Title
  
  KAGAKU TO SEIBUTSU
  
  Volume: 54 Issue: 3 Pages: 146-148
- DOI
  10.1271/kagakutoseibutsu.54.146
- NAID
  130005241178
- ISSN
  0453-073X, 1883-6852
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26102714
[Journal Article] Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.2015
- Author(s)
  Ishii K, Tabuchi F, Matsuo M, Tatsuno K, Sato T, Okazaki M, Hamamoto H, Matsumoto Y, Kaito C, Aoyagi T, Hiramatsu K, Kaku M, Moriya K, Sekimizu K.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 17092-17092
- DOI
  10.1038/srep17092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-15H05279, KAKENHI-PROJECT-26670043
[Journal Article] Rational design, synthesis, and biological evaluation of lactam-bridged gramicidin a analogues: discovery of a low-hemolytic antibacterial Peptide2015
- Author(s)
  J. Mao, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue
- Journal Title
  
  ChemMedChem
  
  Volume: 10 Issue: 3 Pages: 540-545
- DOI
  10.1002/cmdc.201402473
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26102714, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26670043
[Journal Article] Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane.2015
- Author(s)
  Hamamoto H, Urai M, Ishii K, Yasukawa J, Paudel A, Murai M, Kaji T, Kuranaga T, Hamase K, Katsu T, Su J, Adachi T, Uchida R, Tomoda H, Yamada M, Souma M, Kurihara H, Inoue M, Sekimizu K.
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 11(2) Issue: 2 Pages: 127-133
- DOI
  10.1038/nchembio.1710
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-13F03093, KAKENHI-PROJECT-24689008, KAKENHI-PROJECT-25460036, KAKENHI-PUBLICLY-26102714, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26670396, KAKENHI-PROJECT-24249047
[Journal Article] Total Synthesis and Biological Evaluation of the Antibiotic Lysocin E and Its Enantiomeric, Epimeric, and N-Demethylated Analogues2015
- Author(s)
  Murai M, Kaji T, Kuranaga T, Hamamoto H, Sekimizu K, and Inoue M
- Journal Title
  
  Angew. Chem. Int. Ed Engl
  
  Volume: 54 Issue: 5 Pages: 1556-1560
- DOI
  10.1002/anie.201410270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24689008, KAKENHI-PUBLICLY-26102714, KAKENHI-PROJECT-26253003
[Journal Article] 新規MRSA抗生物質ライソシンEの発見 -カイコを用いる治療効果を指向したスクリーニング創薬2015
- Author(s)
  浜本洋関水和久
- Journal Title
  
  化学
  
  Volume: 70 Pages: 12-16
- NAID
  40020505825
- Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26102714
[Journal Article] 新規MRSA抗生物質ライソシンEの発見 -カイコを用いる治療効果を指向したスクリーニング創薬2015
- Author(s)
  浜本洋、関水和久
- Journal Title
  
  化学
  
  Volume: 70 Pages: 12-16
- NAID
  40020505825
- Data Source
  KAKENHI-PROJECT-26670043
[Journal Article] A novel mutation in the vraS gene of Staphylococcus aureus contributes to daptomycin resistance2015
- Author(s)
  Su J, Iehara M, Yasukawa J, Matsumoto Y, Hamamoto H, Sekimizu K
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 印刷中 Issue: 10 Pages: 646-648
- DOI
  10.1038/ja.2015.42
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24689008, KAKENHI-PUBLICLY-26102714, KAKENHI-PROJECT-26460062
[Journal Article] Paralytic peptide: an insect cytokine that mediates innate immunity.2015
- Author(s)
  Ishii K, Hamamoto H, Sekimizu K.
- Journal Title
  
  Archives of Insect Biochemistry and Physiology
  
  Volume: 88(1) Issue: 1 Pages: 18-30
- DOI
  10.1002/arch.21215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-24689008
[Journal Article] Induction of Virulence Gene Expression in Staphylococcus aureus by Pulmonary Surfactant.2014
- Author(s)
  Ishii K, Adachi T, Yasukawa J, Suzuki Y, Hamamoto H, Sekimizu K.
- Journal Title
  
  Infection and immunity
  
  Volume: 82(4) Issue: 4 Pages: 1500-10
- DOI
  10.1128/iai.01635-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10784, KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-24689008, KAKENHI-PROJECT-221S0002
[Journal Article] Identification of a Serratia marcescens virulence factor that promotes hemolymph bleeding in the silkworm, Bombyx mori.2014
- Author(s)
  Ishii K, Adachi T, Hara T, Hamamoto H, Sekimizu K.
- Journal Title
  
  Journal of Invertebrate Pathology
  
  Volume: 117 Pages: 61-67
- DOI
  10.1016/j.jip.2014.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24689008
[Journal Article] カイコを用いた創薬研究2014
- Author(s)
  松本靖彦、浜本洋、西田智、関水和久
- Journal Title
  
  生体の科学
  
  Volume: 65 Pages: 613-620
- NAID
  40020290149
- Data Source
  KAKENHI-PROJECT-26670043
[Journal Article] カイコをモデル動物とした創薬研究展開2014
- Author(s)
  浜本洋
- Journal Title
  
  JATAFFジャーナル
  
  Volume: 2 Pages: 38-43
- Data Source
  KAKENHI-PUBLICLY-26102714
[Journal Article] カイコを用いた創薬研究2014
- Author(s)
  松本靖彦、浜本洋、西田智、関水和久
- Journal Title
  
  生体の科学,
  
  Volume: 65 Pages: 613-620
- NAID
  40020290149
- Data Source
  KAKENHI-PUBLICLY-26102714
[Journal Article] カイコを用いた創薬研究2014
- Author(s)
  松本靖彦、浜本洋、西田智、関水和久
- Journal Title
  
  生体の科学
  
  Volume: 65 Pages: 613-620
- NAID
  40020290149
- Data Source
  KAKENHI-PROJECT-24689008
[Journal Article] In vitro and in vivo anti-MRSA activities of nosokomycins2014
- Author(s)
 Uchida R, Hanaki H, Matsui H, Hamamoto H, Sekimizu K, Iwatsuki M, Kim YP, Tomoda H
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 8 Issue: 6 Pages: 249-254
- DOI
 10.5582/ddt.2014.01050
- NAID
 130005054796
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-24689008, KAKENHI-PROJECT-25460130, KAKENHI-PUBLICLY-26102714
[Journal Article] Establishment of a bacterial infection model using the European honeybee, Apis mellifera L.2014
- Author(s)
  Ishii K, Hamamoto H, Sekimizu K.
- Journal Title
  
  PLoS One.
  
  Volume: 24;9(2) Issue: 2 Pages: e89917-e89917
- DOI
  10.1371/journal.pone.0089917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PUBLICLY-24102510, KAKENHI-PROJECT-24689008
[Journal Article] カイコをモデル動物とした創薬2014
- Author(s)
  浜本洋、関水和久
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 578-582
- Data Source
  KAKENHI-PROJECT-26670043
[Journal Article] Silkworm as a model animal for drug development2014
- Author(s)
  浜本洋、関水和久
- Journal Title
  
  生化学
  
  Volume: 86 Pages: 578-582
- NAID
  40020254204
- Data Source
  KAKENHI-PROJECT-24689008
[Journal Article] カイコをモデル動物とした創薬研究展開2014
- Author(s)
  浜本洋
- Journal Title
  
  JATAFFジャーナル
  
  Volume: 2 Pages: 38-43
- Data Source
  KAKENHI-PROJECT-26670043
[Journal Article] カイコをモデル動物とした創薬研究展開2014
- Author(s)
  浜本洋
- Journal Title
  
  JATAFFジャーナル
  
  Volume: 2 Pages: 38-43
- Data Source
  KAKENHI-PROJECT-24689008
[Journal Article] カイコをモデル動物とした創薬2014
- Author(s)
  浜本洋、関水和久
- Journal Title
  
  生化学
  
  Volume: 86 Pages: 578-582
- Data Source
  KAKENHI-PUBLICLY-26102714
[Journal Article] Serratia marcescens SupPresses Host Cellular lmmunity via the Production of an Adhesion-illhibltory Factor against Immunosurveillance Cells.2014
- Author(s)
  Ishii K, Adachi T, Hamarrioto H, Sekimizu K.
- Journal Title
  
  Journal of Biological Chemistry.
  
  Volume: 289(9) Issue: 9 Pages: 5876-88
- DOI
  10.1074/jbc.m113.544536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10784, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24689008
[Journal Article] Use of silkworms to evaluate the pathogenicity of bacteria attached to cedar pollen2013
- Author(s)
  Hu Y, Hamamoto H, Sekimizu K.
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 7 Issue: 4 Pages: 153-157
- DOI
  10.5582/ddt.2013.v7.4.153
- NAID
  130005054772
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24659041
[Journal Article] Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents.2013
- Author(s)
  Paudel A, Kaneko K, Watanabe A, Shigeki M, Motomu K, Hamamoto H, Sekimizu K.
- Journal Title
  
  J Antibiot (Tokyo).
  
  Volume: 66(11) Issue: 11 Pages: 663-667
- DOI
  10.1038/ja.2013.69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05013, KAKENHI-PROJECT-13F03093, KAKENHI-PROJECT-24659041, KAKENHI-PROJECT-24689008
[Journal Article] Antimicrobial action mechanism of flavonoids from Dorstenia species2013
- Author(s)
 Dzoyem JP, Hamamoto H, Ngameni B, Ngadjui BT, Sekimizu K
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 7 Issue: 2 Pages: 66-72
- DOI
 10.5582/ddt.2013.v7.2.66
- NAID
 130004588093
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PUBLICLY-24102510, KAKENHI-PROJECT-24659041, KAKENHI-PROJECT-24689008
[Journal Article] Insect cytokine paralytic peptide activates innate immunity via nitric oxide production in the silkworm Bombyx mori.2013
- Author(s)
  Ishii K, Adachi T, Hamamoto H, Oonishi T, Kamimura M, Imamura K, Sekimizu K.
- Journal Title
  
  Dev Comp Immunol.
  
  Volume: 39(3) Issue: 3 Pages: 147-53
- DOI
  10.1016/j.dci.2012.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10632, KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24689008
[Journal Article] Xanthurenic acid is an endogenous substrate for the silkworm cytosolic sulfotransferase, bmST1.2012
- Author(s)
  Akira Kushida, Ryo Horie, Kenji Hattori, Hiroshi Hamamoto, Kazuhisa Sekimizu, Hiroomi Tamura
- Journal Title
  
  Journal of Insect Physiology
  
  Volume: 58 Issue: 1 Pages: 83-88
- DOI
  10.1016/j.jinsphys.2011.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659074
[Journal Article] Animal welfare and use of silkworm as a model animal2012
- Author(s)
  Nobukazu Sekimizu, Atmika Paudel, Hiroshi Hamamoto
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 6 Issue: 4 Pages: 226-229
- DOI
  10.5582/ddt.2012.v6.4.226
- NAID
  130005054754
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659074, KAKENHI-PROJECT-24689008
[Journal Article] Evaluation of innate immune stimulating activity of polysaccharides using a silkworm (Bombyx mori) muscle contraction assay2012
- Author(s)
 Fujiyuki T
- Journal Title
 
 Drug Discoveries & Therapeutics
 
 Volume: 6 Issue: 2 Pages: 88-93
- DOI
 10.5582/ddt.2012.v6.2.88
- NAID
 130005054745
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-23659074, KAKENHI-PROJECT-24689008
[Journal Article] Serratia marcescens induces apoptotic cell death in host immune cells via a lipopolysaccharide- and flagella-dependent mechanism.2012
- Author(s)
  Kenichi Ishii, et al.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 287 Issue: 43 Pages: 36582-36592
- DOI
  10.1074/jbc.m112.399667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24580104, KAKENHI-PROJECT-24689008
[Journal Article] Identification of Novel Therapeutically Effective Antibiotics Using Silkworm Infection Model2012
- Author(s)
  Hiroshi Hamamoto, Makoto Urai, Atmika Paudel, Ryo Horie, Kazuhisa Murakami, Kazuhisa Sekimizu
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 132 Issue: 1 Pages: 79-84
- DOI
  10.1248/yakushi.132.79
- NAID
  130001871966
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2012-01-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-23659074
[Journal Article] Lipopolysaccharide O-antigen of enterohemorrhagic Escherichia coli 0157:H7 is required for killing both insects and mammals.2012
- Author(s)
  Atsushi Miyashita, et al.
- Journal Title
  
  FEMS Microbiology Letters
  
  Volume: 333 Issue: 1 Pages: 59-68
- DOI
  10.1111/j.1574-6968.2012.02599.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-23590528, KAKENHI-PROJECT-24590519, KAKENHI-PROJECT-24689008
[Journal Article] Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay2011
- Author(s)
  Dhital S, Hamamoto H, Urai M, Ishii K, Sekimizu K
- Journal Title
  
  Drug Discoveries and Therapeutics 5
  
  Pages: 18-25
- NAID
  130005054690
- Data Source
  KAKENHI-PROJECT-21790063
[Journal Article] Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay2011
- Author(s)
  Dhital S, Hamamoto H, Urai M, Ishii K, Sekimizu K
- Journal Title
  
  Drug Discoveries and Therapeutics
  
  Volume: 5 Pages: 18-25
- NAID
  130005054690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790063
[Journal Article] Insect cytokine paralytic peptide (PP) induces cellular and humoral immune responses in the silkworm Bombyx mori.2010
- Author(s)
  Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 285 Pages: 28635-28642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790063
[Journal Article] Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.2010
- Author(s)
  Asami Y, Horie R, Hamamoto H, Sekimizu K.
- Journal Title
  
  BMC Pharmacology
  
  Volume: 10 Pages: 7-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790063
[Journal Article] The insect cytokine paralytic peptide (PP) induces cellular and humoral immune responses in the silkworm Bombyx mori,2010
- Author(s)
  Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K
- Journal Title
  
  J Biol Chem 285
  
  Pages: 28635-28642
- Data Source
  KAKENHI-PROJECT-21790063
[Journal Article] Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae.2010
- Author(s)
  Ishii K, Hamamoto H, Imamura K, Adachi T, Shoji M, Nakayama K, Sekimizu K.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 285 Pages: 33338-33347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790063
[Journal Article] Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae,2010
- Author(s)
  Ishii K, Hamamoto H, Imamura K, Adachi T, Shoji M, Nakayama K, Sekimizu K
- Journal Title
  
  J Biol Chem 285
  
  Pages: 33338-33347
- Data Source
  KAKENHI-PROJECT-21790063
[Journal Article] Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.2010
- Author(s)
  Fujiyuki T, Imamura K, Hamamoto H, Sekimizu K
- Journal Title
  
  Drug Discoveries and Therapeutics
  
  Volume: 4 Pages: 349-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790063
[Journal Article] Silkworm as a model animal to evaluate drug candidate toxicity and metabolism2009
- Author(s)
  Hamamoto H, Tonoike A, Narushima K, Horie R, Sekimizu K.
- Journal Title
  
  Comp Biochem Physiol C Toxicol Pharmacol 149
  
  Pages: 334-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790063
[Journal Article] Hemocytes and humoral factors in silkworm blood are cooperatively involved in sheep erythrocyte aggregation
- Author(s)
  Imamura K, Ishii K, Hamamoto H, Sekimizu K
- Journal Title
  
  Drug Discoveries and Therapeutics inpress
- NAID
  130005054704
- Data Source
  KAKENHI-PROJECT-21790063
[Patent] 植物体由来の自然免疫活性化作用が増強された自然免疫活性化組成物2009
- Inventor(s)
  関水和久、浜本洋、小方康至
- Industrial Property Rights Holder
  関水和久、浜本洋、小方康至
- Filing Date
  2009-06-22
- Overseas
- Data Source
  KAKENHI-PROJECT-21790063
[Patent] 自然免疫機構を活性化/抑制する作用を有する物質の評価方法及びスクリーニング方法、並びに、自然免疫機構を活性化/抑制するための薬剤、食品及びそれらの製造方法2008
- Inventor(s)
  関水和久、浜本洋
- Industrial Property Rights Holder
  関水和久、浜本洋
- Industrial Property Number
  2009-509376
- Filing Date
  2008-04-10
- Data Source
  KAKENHI-PROJECT-21790063
[Patent] 自然免疫機能活性化組成物の製造方法及び自然免疫機能活性化組成物2008
- Inventor(s)
  関水和久、浜本洋
- Industrial Property Rights Holder
  関水和久、浜本洋
- Industrial Property Number
  2009-148108
- Filing Date
  2008-07-02
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] ライソシンの研究開発2025
- Author(s)
  浜本洋
- Organizer
  AMED-CREST 感染症創薬基盤感染症創薬アライアンス・キックオフ会議
- Invited
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] 抗菌薬の新たな可能性を示す新規抗生物質ライソシンE2025
- Author(s)
  浜本洋
- Organizer
  学校法人北里大学 2024年度第34回学会賞受賞者特別講演
- Invited
- Data Source
  KAKENHI-PROJECT-24KF0177
[Presentation] 抗菌薬の新たな可能性を示す新規抗生物質ライソシンE2025
- Author(s)
  浜本洋
- Organizer
  学校法人北里大学 2024年度第34回学会賞受賞者特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] Usefulness of silkworm model for drug candidate screening2024
- Author(s)
  Hiroshi Hamamoto
- Organizer
  The 3rd International symposium on High Altitude Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] カイコ真菌感染モデルを用いた病原性および抗真菌薬の治療効果の評価2024
- Author(s)
  浜本洋
- Organizer
  第8回東北医真菌研究会
- Data Source
  KAKENHI-PROJECT-24KF0177
[Presentation] The utility of silkworm models in the development of novel infectious disease therapeutics2024
- Author(s)
  Hiroshi Hamamoto
- Organizer
  The 16th Japan-Korea International Symposium on Microbiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24KF0177
[Presentation] 黄色ブドウ球菌の病原性に寄与する低分子抗酸化物質2024
- Author(s)
  浜本洋
- Organizer
  第76回日本細菌学会東北支部総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] Silkworm Infection Model in Fungal Research and Development2024
- Author(s)
  Hiroshi Hamamoto
- Organizer
  The 8th Congress of Asia-Pacific Society for Medical Mycology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24KF0177
[Presentation] lucidation of the bactericidal mechanism of Lysocin E, an ultra-short-time bactericidal antimicrobial agent2024
- Author(s)
  Hiroshi Hamamoto
- Organizer
  ASM Microbe 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] The utility of silkworm models in the development of novel infectious disease therapeutics2024
- Author(s)
  Hiroshi Hamamoto
- Organizer
  The 16th Japan-Korea International Symposium on Microbiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] Silkworm Infection Model in Fungal Research and Development2024
- Author(s)
  Hiroshi Hamamoto
- Organizer
  The 8th Congress of Asia-Pacific Society for Medical Mycology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] ライソシンEの強力な殺菌の作用機序解析2024
- Author(s)
  浜本洋
- Organizer
  第98回日本感染症学会学術講演会第72回日本化学療法学会総会合同学会
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] 超短時間殺菌性抗菌化合物としてのライソシン E の作用機序解析2023
- Author(s)
  浜本洋
- Organizer
  第67回　日本ブドウ球菌研究会
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] 新規抗生物質ライソシンEの作用機序と開発2023
- Author(s)
  浜本洋
- Organizer
  第３５回微生物シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] カイコを用いた敗血症性DIC (播種性血管内凝固症候群)モデルの構築2023
- Author(s)
  関水和久、宮下惇嗣、李文渊、三上雄大、Yu Yidong、浜本洋
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-21H02733
[Presentation] 超短時間殺菌性抗菌化合物としてのライソシン E の作用機序解析2023
- Author(s)
  浜本洋
- Organizer
  第75回日本細菌学会東北支部
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] カイコ感染モデルを用いて同定した新規抗生物質ライソシンに関する研究2023
- Author(s)
  浜本洋
- Organizer
  公益財団法人日本感染症医薬品協会　メディカル・サイエンスセミナー－住木・梅澤記念賞及び奨励賞授賞式、受賞講演並びに特別講演－
- Invited
- Data Source
  KAKENHI-PROJECT-23K27410
[Presentation] 新規抗生物質ライソシンEは宿主と微生物の相互作用を利用して高い治療効果を発揮する2022
- Author(s)
  浜本洋、Suresh Panthee、Atmika Paudel、宮下惇嗣、関水和久
- Organizer
  第95回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] Cryptococcus neoformansの病原性因子の網羅的探索2021
- Author(s)
  浜本洋、石島早苗、Suresh Panthee、Atmika Paudel、関水和久
- Organizer
  第65回日本医真菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] Anitimycobacterial activities of Lysocin E against Mycobacterial species in vitro2020
- Author(s)
  ガブリスタディクガブリミカエル、稲泉茜、西山晃史、山口雄大、尾関有里子、立石善隆、浜本洋、関水和久、松本壮吉
- Organizer
  第93回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] 宿主-微生物相互作用によるライソシン E の治療効果の増強2020
- Author(s)
  浜本洋、Suresh Panthee、Atmika Paudel、関水和久
- Organizer
  第32回微生物シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] 新規抗MRSA薬としてのライソシンEの特長2020
- Author(s)
  浜本洋、関水和久
- Organizer
  第65回日本ブドウ球菌研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] 酵母加熱死菌によるカイコの自然免疫の過度な活性化と殺傷2020
- Author(s)
  石島早苗、宮下惇嗣、浜本洋、関水和久
- Organizer
  第64回日本医真菌学会総会・学術総会
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] カイコを用いた抗菌・抗真菌薬の探索2020
- Author(s)
  関水和久、橋本佳奈、浜本洋
- Organizer
  第65回日本ブドウ球菌研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] Cryptococcus neoformansの病原性因子の網羅的探索2020
- Author(s)
  浜本洋、石島早苗、Suresh Panthee、Atmika Paudel、関水和久
- Organizer
  第64回日本医真菌学会総会・学術総会
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] 黄色ブドウ球菌の宿主感染後の時間経過に伴う網羅的遺伝子発現変化の解析2019
- Author(s)
  浜本洋、Suresh Panthee、Atmika Paudel、関水和久
- Organizer
  第64回日本ブドウ球菌研究会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Cryptococcus neoformansのマウス感染状態における網羅的遺伝子発現解析2019
- Author(s)
  浜本洋、Suresh Panthee、Atmika Paudel、石島早苗、関水和久
- Organizer
  第63回日本医真菌学会総会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 薬物評価系としてのカイコの利用と新規抗菌剤の開発2019
- Author(s)
  浜本洋
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Comprehensive gene expression analysis of Cryptococcus neoformans infected in mouse brain2019
- Author(s)
  Hiroshi Hamamoto、Sanae Ishijima、Suresh Panthee、Paudel Atmika、Kazuhisa Sekimizu
- Organizer
  ASM Microbe 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Discovering novel roles of genes for virulence of Staphylococcus aureus USA300 using invertebrate model silkworm2019
- Author(s)
  Suresh Panthee、Hiroshi Hamamoto、Atmika Paudel、Kazuhisa Sekimizu
- Organizer
  ASM Microbe 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 新規抗生物質「ライソシン」の開発2019
- Author(s)
  関水和久、浜本洋
- Organizer
  第2回薬剤耐性(AMR)シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] ナノポアシークエンサーを用いたCandida albicans TIMM1768株の全ゲノム解析2019
- Author(s)
  浜本洋、Suresh Panhtee、石島早苗、関水和久
- Organizer
  第40回関東医真菌懇話会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] ナノポアシークエンサーを用いたCandida albicans TIMM1768株の全ゲノム解析2019
- Author(s)
  浜本洋、Suresh Panhtee、石島早苗、関水和久
- Organizer
  第40回関東医真菌懇話会
- Data Source
  KAKENHI-PROJECT-19K07140
[Presentation] 治療効果を指向した新規感染症治療薬の同定と開発2019
- Author(s)
  浜本洋、Suresh Panthee、石島早苗、関水和久
- Organizer
  第42回白金シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 新規抗生物質「ライソシン」の開発2019
- Author(s)
  関水和久、浜本洋
- Organizer
  第2回薬剤耐性(AMR)シンポジウム
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 細菌感染症研究における様々な網羅的RNA解析手法2018
- Author(s)
  浜本洋、Panthee Suresh、Paudel Atmika、鈴木穣、関水和久
- Organizer
  第91回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコを用いた新規感染症治療薬の同定と開発2018
- Author(s)
  浜本洋、Suresh Panthee、石島早苗、関水和久
- Organizer
  第101回日本細菌学会関東支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Identification of novel genes required for virulence of Staphylococcus aureus USA300 using invertebrate model silkworm2018
- Author(s)
  Paudel A、Hamamoto H、Panthee S、Sekimizu K
- Organizer
  Asian Invertebrate Immunity Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] ナノポアシークエンサーを用いたCandida albicans TIMM1768株の全ゲノム解析2018
- Author(s)
  浜本洋、Suresh Panthee、石島早苗、関水和久
- Organizer
  第62回日本医真菌学会総会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 医薬品開発におけるカイコモデルの利点と実際の応用2018
- Author(s)
  浜本洋
- Organizer
  第2回公開シンポジウム「カイコ・シルク産業の未来～”蚕業革命”から”産業革命”へ～」
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] In-vivo transcriptomic analysis of Staphylococcus aureus from infected organs2018
- Author(s)
  Panthee S、Hamamoto H、Paudel A、Sekimizu K
- Organizer
  18th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Pharmacokinetics and metabolism of antibiotics in the silkworm model2018
- Author(s)
  Hamamoto H、Horie R、Panthee S、Paudel A、Sekimizu K
- Organizer
  ASM microbe 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Silkworm model is useful for the identification of novel pathogenic genes2018
- Author(s)
  Hamamoto H、Paudel A、Panthee S、Sekimizu K
- Organizer
  18th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコモデルの創薬における利用2018
- Author(s)
  浜本洋
- Organizer
  第9回日本昆虫科学連合・日本学術会議　公開シンポジウム　「昆虫の恵みII 」
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Candida albicans TIMM1768株の酵母系、菌糸形での発現遺伝子解析2018
- Author(s)
  石島早苗、浜本洋、山田剛、安部茂、関水和久
- Organizer
  第62回日本医真菌学会総会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ感染モデルでのバンコマイシン耐性黄色ブドウ球菌に対するバンコマイシンの治療効果2018
- Author(s)
  光冨修平、浜本洋、垣内力、関水和久
- Organizer
  第30回微生物シンポジウム
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] BmPP, insect cytokine regulate broad function of innate immunity2018
- Author(s)
  Hamamoto H
- Organizer
  Asian Invertebrate Immunity Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Therapeutic activity of antimicrobial agents is correlated with the appropriate pharmacokinetics in silkworms2018
- Author(s)
  Paudel A、Panthee S、Urai M、Hamamoto H、Ohwada T、Sekimizu K
- Organizer
  ASM microbe 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコモデルを利用した新規抗生物質ライソシンEの同定と開発2017
- Author(s)
  浜本洋、関水和久
- Organizer
  第66回日本感染症学会東日本地方会学術集会・第64回日本化学療法学会東日本支部総会合同学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 黄色ブドウ球菌のマウス宿主内で発現上昇する遺伝子群の解析2017
- Author(s)
  浜本洋、扇喜秀、Panthee Suresh、Paudel Atmika, 鈴木穣、関水和久
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-19
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ細菌・真菌感染モデルを用いた新規抗生物質の開発2017
- Author(s)
  浜本洋、関水和久
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 黄色ブドウ球菌の嫌気呼吸系発現上昇の病原性に対する寄与2017
- Author(s)
  浜本洋、扇喜秀、Panthee Suresh、Paudel Atmika、鈴木穣、関水和久
- Organizer
  2017年度生命科学学会合同年次大会 ConBio2017
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ細菌感染モデルにおける治療効果を指標とした抗菌薬の合成展開法の確立2017
- Author(s)
  浜本洋、Atmika Paudel、Suresh Panthee、浦井誠、大和田智彦、関水和久
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ細菌感染モデルによって得られた新規抗生物質ライソシン Eの発見と開発2016
- Author(s)
  浜本洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] Identification and mechanistic analysis of a novel antibiotic lysocin E2016
- Author(s)
  Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  The 8th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  パシフィックホテル沖縄（沖縄県那覇市）
- Year and Date
  2016-01-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] 創薬へのカイコモデルの応用2016
- Author(s)
  浜本洋、関水和久
- Organizer
  昆虫デザイン研究会　家畜化過程の理解とポスト家畜化
- Place of Presentation
  岡崎コンファレンスセンター（愛知県岡崎市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Identification and mechanistic analysis of a novel antibiotic lysocin E2016
- Author(s)
  Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  The 8th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  Pacific Hotel Okinawa (Okinawa, Japan)
- Year and Date
  2016-01-18
- Invited
- Data Source
  KAKENHI-PROJECT-26670043
[Presentation] Silkworm Model for Drug Discovery and Drug Development.2016
- Author(s)
  Kazuhisa Sekimizu, Hiroshi Hamamoto
- Organizer
  The 13th Asia Pacific Federation of Pharmacologist Meeting "New Paradigms in Pharmacology for Global Health"
- Place of Presentation
  Bangkok (Thailand)
- Year and Date
  2016-02-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Identification and mechanistic analysis of a novel antibiotic lysocin E2016
- Author(s)
  Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  The 8th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  パシフィックホテル沖縄（沖縄県那覇市）
- Year and Date
  2016-01-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ感染実験系の有用性と課題　ライソシンEの研究を中心として2016
- Author(s)
  浜本洋
- Organizer
  メディカル・サイエンス　セミナー
- Place of Presentation
  学士会館（千代田区神保町）
- Year and Date
  2016-03-24
- Invited
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] An Antibacterial Agent Inhibited Bacterial Transcription by Targeting the Primary Sigma Factor and Preventing Open Complex Formation2016
- Author(s)
  Atmika Paudel, Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  ASM Microbe
- Place of Presentation
  Boston（MA. USA）
- Year and Date
  2016-06-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ細菌感染モデルによって得られた新規抗生物質ライソシン Eの発見と開発2016
- Author(s)
  浜本洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ真菌感染モデルを利用した抗真菌薬の治療効果の評価と探索2016
- Author(s)
  浜本洋、関水和久
- Organizer
  第60回医真菌学会総会・学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 新規抗生物質ライソシンEの同定と作用メカニズム2016
- Author(s)
  浜本洋、関水和久
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] 新規抗生物質ライソシンEの同定と作用メカニズム2016
- Author(s)
  浜本洋、関水和久
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ感染実験系の有用性と課題　ライソシンEの研究を中心として2016
- Author(s)
  浜本洋
- Organizer
  メディカル・サイエンス　セミナー
- Place of Presentation
  学士会館（千代田区神保町）
- Year and Date
  2016-03-24
- Invited
- Data Source
  KAKENHI-PROJECT-26670043
[Presentation] Host factors enhance antimicrobial activity of “Lysocin E”2015
- Author(s)
  Hiroshi Hamamoto, Jie Su, Keniichi Ishii, Jyunichiro Yasukawa, Atmika Paudel, Kazuhisa Sekimizu
- Organizer
  The international chemical congress of pacific basin societies 2015 (Pacifichem 2015)
- Place of Presentation
  Honolulu (Hawaii, USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ細菌感染モデルにて同定された新規抗生物質ライソシンE2015
- Author(s)
  浜本洋、関水和久
- Organizer
  第64回日本感染症学会東日本地方学術集会、第62回日本化学療法学会東日本支部総会　合同学会
- Place of Presentation
  ロイトン札幌（北海道札幌市）
- Year and Date
  2015-10-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 宿主臓器における遺伝子発現上昇を指標とした黄色ブドウ球菌の新規病原性因子の探索2015
- Author(s)
  扇喜秀、浜本洋、鈴木穣、関水和久
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻キャンパス（千葉県千葉市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ真菌感染モデルを利用した抗真菌薬の治療効果の評価と探索2015
- Author(s)
  浜本洋、関水和久
- Organizer
  第36回関東医真菌懇話会
- Place of Presentation
  京王プラザホテル（新宿区西新宿）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-26670043
[Presentation] Host factors enhance antimicrobial activity of “Lysocin E”2015
- Author(s)
  Hiroshi Hamamoto, Jie Su, Keniichi Ishii, Jyunichiro Yasukawa, Atmika Paudel, Kazuhisa Sekimizu
- Organizer
  The international chemical congress of pacific basin societies 2015 (Pacifichem 2015)
- Place of Presentation
  Honolulu (Hawaii, USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] カイコ細菌感染モデルにて同定された新規抗生物質ライソシンE2015
- Author(s)
  浜本洋、関水和久
- Organizer
  第64回日本感染症学会東日本地方学術集会、第62回日本化学療法学会東日本支部総会　合同学会
- Place of Presentation
  ロイトン札幌（北海道札幌市）
- Year and Date
  2015-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-26670043
[Presentation] 宿主因子による抗生物質カイコシンの抗菌活性の促進2015
- Author(s)
  浜本洋、安川淳一朗、石井健一、Su Jie、Paudel Atmika、関水和久
- Organizer
  第37回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  熊本大学薬学部（熊本県熊本市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] カイコ細菌感染モデルにて同定された新規抗生物質ライソシンE2015
- Author(s)
  浜本洋、関水和久
- Organizer
  第64回日本感染症学会東日本地方学術集会、第62回日本化学療法学会東日本支部総会　合同学会
- Place of Presentation
  ロイトン札幌（北海道札幌市）
- Year and Date
  2015-10-21
- Invited
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] Identification and mechanistic analysis of novel antibiotic “Lysocin E”2015
- Author(s)
  Kazuhisa Sekimizu, Hiroshi Hamamoto
- Organizer
  The international chemical congress of pacific basin societies 2015 (Pacifichem 2015)
- Place of Presentation
  Honolulu (Hawaii, USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 宿主臓器における遺伝子発現上昇を指標とした黄色ブドウ球菌の新規病原性因子の探索2015
- Author(s)
  扇喜秀、浜本洋、鈴木穣、関水和久
- Organizer
  BMB2015　第38回日本分子生物学会年会、第88回日本生化学会　合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 宿主臓器に感染した黄色ブドウ球菌のRNA-Seq解析に基づく新規病原性因子の探索2015
- Author(s)
  浜本洋
- Organizer
  新学術領域「ゲノム支援」２０１５年度拡大班会議
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] マウス臓器に感染した黄色ブドウ球菌の網羅的遺伝子発現解析2015
- Author(s)
  浜本洋、扇喜秀、鈴木穣、Paudel Atmika, 関水和久
- Organizer
  第27回微生物シンポジウム
- Place of Presentation
  岡山大学（岡山県岡山市）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 新規抗生物質ライソシンの抗菌活性を促進する血清因子のメカニズム解析2015
- Author(s)
  浜本洋、関水和久
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第8回公開シンポジウム
- Place of Presentation
  東北大学仙台南キャンパス萩ホール（仙台市宮城県）
- Year and Date
  2015-06-08
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] 治療効果を指向した新規抗生物質の開発に向けて2014
- Author(s)
  浜本洋
- Organizer
  文部科学省科学研究費新学術領域研究「ゲノム支援」公開シンポジウム
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] Silkworm as an animal model for novel antibiotic development2014
- Author(s)
  Hiroshi Hamamoto
- Organizer
  10th European Congress of Entomology
- Place of Presentation
  York (UK)
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 新規抗生物質カイコシンの作用機序と宿主因子による活性化2014
- Author(s)
  浜本洋、安川淳一朗、石井健一、安達達朗、関水和久
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本県熊本市）
- Invited
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] カイコを用いた抗菌活性物質スクリーニング法2014
- Author(s)
  安川淳一朗、浜本洋、Su Jie、Paudel Atmika、浦井誠、西田智、関水和久
- Organizer
  新学術領域「天然物ケミカルバイオロジー～分子標的と活性制御～」　第５回若手研究者ワークショップ
- Place of Presentation
  名古屋大学（愛知県名古屋市）
- Year and Date
  2014-05-29
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] Characterization and mechanistic analysis of novel antibiotics Kaikosin, produced by Lysobacter sp.2013
- Author(s)
  Hiroshi Hamamoto, Su Jie, Paudel Atomika, Makoto Urai, Kazuhisa Sekimizu
- Organizer
  International Symposium on Genome Science Expanding Frontiers of Genome Science
- Place of Presentation
  東京都
- Year and Date
  2013-01-09
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] 新規抗視物質カイコシンの作用機序解析2013
- Author(s)
  浜本洋、Su Jie、Atmika Paudel、西田智、関水和久
- Organizer
  第25回微生物シンポジウム
- Place of Presentation
  静岡県立大学（静岡県静岡市）
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] カイコ細菌感染モデルを用いた治療有効な新規抗生物質カイコシンの作用機序解析2013
- Author(s)
  安川淳一朗、浜本洋、Jie Su、Atmika Paudel、浦井誠、石井健一、安達達朗、西田智、関水和久
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋、石川繭子、瀬筒秀樹、坪田拓也、片岡啓子、松本靖彦、垣内力、関水和久
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 新規抗生物質カイコシンによる新規細胞膜破壊メカニズム2013
- Author(s)
  安川淳一朗、浜本洋、Jie Su、Atmika Paudel、浦井誠、石井健一、安達健朗、西田智、関水和久
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学（東京都文京区）
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] Molecular Target analysis of the Novel Antibiotics Kaikosins2013
- Author(s)
  K Sekimizu, H Hamamoto
- Organizer
  The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋、石川繭子、瀬筒秀樹、坪田拓也、片岡啓子、松本靖彦、垣内力、関水和久
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市(招待講演)
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋
- Organizer
  日本実験動物抱いた法学会第26回大会
- Place of Presentation
  京都テレサ, 京都府京都市
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] Molecular Target analysis of Novel Antibiotics Kaikosins2013
- Author(s)
  H. HAMAMOTO, J. Su, A. PAUDEL, M. URAI, K. KATAOKA, K. SEKIMIZU
- Organizer
  53th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
- Place of Presentation
  USA (Denver)
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] 次世代シークエンサーを用いた黄色ブドウ球菌の宿主応答因子の網羅的な解析手法2013
- Author(s)
  浜本洋、石井健一、安達健朗、鈴木穣、関水和久
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートピアホテル（兵庫県神戸市）
- Invited
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋
- Organizer
  日本動物実験代替法学会第26回大会
- Place of Presentation
  京都テレサ（京都府京都市）
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋、石川繭子、瀬筒秀樹、坪田拓也、片岡啓子、松本靖彦、垣内力、関水和久
- Organizer
  日本薬学会第133年会
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋、石川繭子、瀬筒秀樹、坪田拓也、片岡啓子、松本靖彦、垣内力、関水和久
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] Antibacterial activity of a novel lipopeptide antibiotic, kaikosin E, is enhanced by host factors2013
- Author(s)
  J. Yasukawa, H. Hamamoto, J. Su, Paudel A, M. Urai, S. Nishida, K. Sekimizu
- Organizer
  The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋、石川繭子、瀬筒秀樹、坪田拓也、片岡啓子、松本靖彦、垣内力、関水和久
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜(招待講演)
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋
- Organizer
  日本動物実験代替法学会第26回大会
- Place of Presentation
  京都テレサ（京都府京都市）
- Invited
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] Silkworm（カイコ）を用いた急性経口毒性試験代替法の開発2012
- Author(s)
  杉田拓也、植木拓朗、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] Silkworm（カイコ）を用いた急性経口毒性試験代替法の開発2012
- Author(s)
  杉田拓也、植木拓朗、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] Silkworm(カイコ)を用いた急性毒性試験代替法の開発2012
- Author(s)
  杉田拓也、植木拓朗、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 新規環状リポペプチド系抗生物質カイコシンの作用機序解析2012
- Author(s)
  浜本洋、Su Jie、浦井誠、Atmika Paudel、片岡啓子、関水和久
- Organizer
  第２４回微生物シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] がん治療薬評価モデルカイコの開発2012
- Author(s)
  石川繭子、浜本洋、坪田拓也、瀬筒秀樹、大西忠博、中尾和貴、饗場篤、片岡啓子、関水和久
- Organizer
  第３５回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] 新規抗生物質カイコシンの作用機序解析に関する研究2012
- Author(s)
  浜本洋、SuJie、AtmikaPaudel、浦井誠、片岡啓子、関水和久
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] Purification of a serum factor enhancing Kaikosin E activity against Staphylococcus aureus2012
- Author(s)
  Su Jie, Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products : Target ID and Regulation of Bioactivity
- Place of Presentation
  東京都
- Year and Date
  2012-10-31
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] がん治療薬評価モデルカイコの開発2012
- Author(s)
  石川繭子、浜本洋、坪田拓也、瀬筒秀樹、大西忠博、中尾和貴、饗場篤、片岡啓子、関水和久
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] Silkworm(カイコ)を用いた急性経口毒性試験代替法の投与方法の検討2012
- Author(s)
  植木拓朗、杉田拓也、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 新規抗生物質カイコシンの作用機序解析に関する研究2012
- Author(s)
  浜本洋、Su Jie、Atmika Paudel、浦井誠、片岡啓子、関水和久
- Organizer
  第３４回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] Silkworm（カイコ）を用いた急性経口毒性試験代替法の投与方法の検討2012
- Author(s)
  植木拓朗、杉田拓也、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] 薬剤性組織障害の動物モデルとしてのカイコの有用性2012
- Author(s)
  稲垣善則、松本靖彦、浜本洋、片岡啓子、松橋直也、杉田拓也、植木拓朗、奥村秀信、関水和久
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 新規抗生物質カイコシンの作用機序解析に関する研究2012
- Author(s)
  浜本洋、Su Jie、Atmika Paudel、浦井誠、片岡啓子、関水和久
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都府
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] Silkworm(カイコ)を用いた急性経口毒性試験代替法の投与方法の検討2012
- Author(s)
  植木拓朗、杉田拓也、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] Silkworm(カイコ)を用いた急性経口毒性試験代替法の開発2012
- Author(s)
  杉田拓也、植木拓朗、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] 新規環状リポペプチド系抗生物質カイコシンの作用機序解析2012
- Author(s)
  浜本洋、SuJie、浦井誠、AtmikaPaudel、片岡啓子、関水和久
- Organizer
  第24回微生物シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] 薬剤性組織障害モデルとしてのカイコの有用性2012
- Author(s)
  稲垣善則、松本靖彦、浜本洋、片岡啓子、松橋直也、杉田拓也、植木拓朗、奥村秀信、関水和久
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 新規環状リポペプチド系抗生物質カイコシンの作用機序解析2012
- Author(s)
  浜本洋、Su Jie、浦井誠、Atmika Paudel、片岡啓子、関水和久
- Organizer
  第24回微生物シンポジウム
- Place of Presentation
  大阪府
- Year and Date
  2012-09-04
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] Silkworm（カイコ）を用いた急性経口毒性試験代替法の投与方法の検討2012
- Author(s)
  植木拓朗、杉田拓也、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] カイコ病態モデルを利用した新規医薬品の開発2011
- Author(s)
  浜本洋
- Organizer
  ポストゲノム昆虫研究会(招待講演)
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] カイコ細菌感染モデルを用いた治療効果を指標とした探索による、新規リポペプチド系抗生物質カイコシンの発見2011
- Author(s)
  浜本洋、浦井誠、アトミカパウデル、堀江亮、村上和久、関水和久
- Organizer
  日本薬学会第131年会(シンポジウム)
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] ヒトシトクロームP450トランスジェニックカイコの作出2011
- Author(s)
  堀江亮、浜本洋、二橋美瑞子、瀬筒秀樹、関水和久
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] セラチア菌のO抗原によるカイコ血球細胞の細胞死誘導2010
- Author(s)
  石井健一、臼井公人、今村亮俊、浜本洋、鈴木一史、渡邉剛志、関水和久
- Organizer
  第32回日本分子生物学会・第83回日本生化学会大会合同年会(BMB2010)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] Insect cytokine paralytic peptide activates innate immunity via nitric oxide production in Bombyx mori2010
- Author(s)
  Kenichi Ishii, Hiroshi Hamamoto, Manabu Kamimura, Kazuhisa Sekimizu
- Organizer
  The 10th Awaji International Forum on Infection and Immunity
- Place of Presentation
  淡路
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] カイコと哺乳動物におけるシトクロームP450代謝反応の共通性2010
- Author(s)
  堀江亮、浜本洋、関水和久
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター(岡山県)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] カイコにおけるシトクロームP450に関する研究2010
- Author(s)
  浜本洋、堀江亮、関水和久
- Organizer
  第33回日本分子生物学会・第83回日本生化学会大会合同年会(BMB2010)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] セラチア菌のO抗原によるカイコ血球細胞の細胞死誘導2010
- Author(s)
  石井健一、臼井公人、今村亮俊、浜本洋、鈴木一史、渡邉剛志、関水和久
- Organizer
  第33回日本分子生物学会・第83回日本生化学会大会合同年会(BMB2010)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] Novel Therapeutically Effective Cyclic Lipopeptide Antibiotics Screened by Silkworm Infection Model2010
- Author(s)
  H.HAMAMOTO, A.PAUDEL, M.URAI, R.HORIE, K.MURAKAMI, T.MOGI, K.SEKIMIZU
- Organizer
  2010 Interscience Conference on Antimicrobial Agents and Chemotherapy
- Place of Presentation
  米国、ボストン
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] カイコ幼虫を用いた安全性試験・有効性試験2010
- Author(s)
  浜本洋
- Organizer
  日本実験代替法学会2010年講習会
- Place of Presentation
  札幌
- Year and Date
  2010-09-20
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] カイコにおいて昆虫サイトカインparalytic peptideにより誘導される自然免疫応答2009
- Author(s)
  石井健一、浜本洋、神村学、中村有希、野田博明、三田和英、関水和久
- Organizer
  第32回分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] カイコにおいて昆虫サイトカイン paralytic peptide により誘導される自然免疫応答2009
- Author(s)
  石井健一、浜本洋、神村学、中村有希、野田博明、三田和英、関水和久
- Organizer
  第32回分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] Metabolic reaction in silkworm by cytochrome P4502009
- Author(s)
  堀江亮、浜本洋、関水和久
- Organizer
  16th International Conference on Cytochrome P450
- Place of Presentation
  万国津梁館(沖縄県)
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] カイコにおけるシトクロームP450代謝反応に関する研究2009
- Author(s)
  堀江亮、浜本洋、関水和久
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] Establishment of novel bioassay system for screening the anti-infectious compounds using silkworm infection model2009
- Author(s)
  Hiroshi Hamamoto, Ryo Horie, Atmika Paudel, Kazuhisa Murakami, Kazuhisa Sekimizu
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪大学(大阪府)
- Year and Date
  2009-11-30
- Data Source
  KAKENHI-PROJECT-21790063
[Presentation] Host factors enhance the antimicrobial activity of a novel antibiotics kaikosin E
- Author(s)
  Hiroshi Hamamoto, Su Jie, Atmika Paudel, Kenichi Ishii, Jyunichiro Yasukawa, Kazuhisa Sekimizu
- Organizer
  The 54th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Place of Presentation
  Washington（USA）
- Year and Date
  2014-09-05 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] 新規抗生物質カイコシンEの治療効果の基礎となる分子メカニズム
- Author(s)
  安川淳一朗、浜本洋、Su Jie、Paudel Atmika、浦井誠、西田智、関水和久
- Organizer
  第87回生化学会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] The primary sigma factor of bacterial RNA polymerase is involved in antimicrobial activity of a novel therapeutically effective antimicrobial agent.
- Author(s)
  Paudel Atmika, Hamamoto Hiroshi, Kaneko Keichi, Matsunaga Shigeki, Suzuki Yutaka, Kanai Motomu, Kazuhisa Sekimizu.
- Organizer
  The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Year and Date
  2014-10-28 – 2014-10-29
- Data Source
  KAKENHI-PROJECT-26670043
[Presentation] Host factors enhance the antimicrobial activity of a novel antibiotics kaikosin E
- Author(s)
  Hiroshi Hamamoto
- Organizer
  The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Year and Date
  2014-10-28 – 2014-10-29
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] Novel Therapeutically Effective Antimicrobial Agent Targets Bacterial RNA Polymerase Sigma Factor A
- Author(s)
  Paudel Atmika, Hamamoto Hiroshi, Kaneko Keichi, Matsunaga Shigeki, Suzuki Yutaka, Kanai Motomu, Kazuhisa Sekimizu
- Organizer
  The 54th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Place of Presentation
  Washington（USA）
- Year and Date
  2014-09-05 – 2014-09-09
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] Silkworm as an animal model for novel antibiotic development
- Author(s)
  Hiroshi Hamamoto, Jyunichiro Yasukawa, Kenich Ishii, Atmika Paudel, Kazuhisa Sekimizu
- Organizer
  the Xth European Congress of Entomology
- Place of Presentation
  York（England）
- Year and Date
  2014-08-03 – 2014-08-08
- Invited
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] 新規抗生物質カイコシンの宿主由来抗菌活性増強因子に関する解析
- Author(s)
  浜本洋
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第8回公開シンポジウム
- Place of Presentation
  名古屋大学（愛知県名古屋市）
- Year and Date
  2014-05-28 – 2014-05-29
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] 宿主因子による新規抗生物質カイコシンE の抗菌活性の増強
- Author(s)
  浜本洋、安川淳一朗、石井健一、Su Jie、Paudel Atmika、関水和久
- Organizer
  第26回微生物シンポジウム
- Place of Presentation
  都センターホテル、東京
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] 宿主因子による抗生物質カイコシンの抗菌活性の促進
- Author(s)
  浜本洋、安川淳一朗、石井健一、Su Jie、Paudel Atmika、関水和久
- Organizer
  第３６回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] カイコ病態モデルを利用した新規医薬品の開発
- Author(s)
  浜本洋
- Organizer
  ポストゲノム昆虫研究会
- Place of Presentation
  福岡(招待講演)
- Data Source
  KAKENHI-PROJECT-23659074
[Presentation] カイコの感染モデルを利用した新規抗生物質ライソシンの発見
- Author(s)
  関水和久、浜本洋
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  長良川国際会議場（岐阜県岐阜市）
- Year and Date
  2015-03-26 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] Novel Therapeutically Effective Antimicrobial Agent Targets Bacterial RNA Polymerase Sigma Factor A
- Author(s)
  Paudel Atmika, Hamamoto Hiroshi, Kaneko Keichi, Matsunaga Shigeki, Suzuki Yutaka, Kanai Motomu, Kazuhisa Sekimizu
- Organizer
  The 54th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Place of Presentation
  Washington（USA）
- Year and Date
  2014-09-05 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-26670043
[Presentation] カイコモデルを用いた治療効果を有する新規抗菌薬の同定と開発
- Author(s)
  浜本洋、石井健一、安川淳一朗、西田智、関水和久
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学園大学（兵庫県神戸市）
- Year and Date
  2015-03-26 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] 宿主因子による新規抗生物質カイコシンE の抗菌活性の増強
- Author(s)
  浜本洋、安川淳一朗、石井健一、Su Jie、Paudel Atmika、関水和久
- Organizer
  第26回微生物シンポジウム
- Place of Presentation
  都センターホテル（東京都千代田区）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] Silkworm as an animal model for novel antibiotic development
- Author(s)
  Hiroshi Hamamoto, Jyunichiro Yasukawa, Kenich Ishii, Atmika Paudel, Kazuhisa Sekimizu
- Organizer
  the Xth European Congress of Entomology
- Place of Presentation
  York（England）
- Year and Date
  2014-08-03 – 2014-08-05
- Invited
- Data Source
  KAKENHI-PROJECT-26670043
[Presentation] カイコモデルを用いた治療効果を有する新規抗菌薬の同定と開発
- Author(s)
  浜本洋、石井健一、安川淳一朗、西田智、関水和久
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学園大学（兵庫県神戸市）
- Year and Date
  2015-03-26 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26670043
[Presentation] 新規抗生物質カイコシンEの治療効果の基礎となる分子メカニズム
- Author(s)
  安川淳一朗、浜本洋、Su Jie、Paudel Atmika、浦井誠、西田智、関水和久
- Organizer
  第87回生化学会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24689008
[Presentation] Host factors enhance the antimicrobial activity of a novel antibiotics kaikosin E
- Author(s)
  Hiroshi Hamamoto, Su Jie, Atmika Paudel, Kenichi Ishii, Jyunichiro Yasukawa, Kazuhisa Sekimizu
- Organizer
  The 54th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Place of Presentation
  Washington（USA）
- Year and Date
  2014-09-05 – 2014-09-09
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] カイコモデルを用いた治療効果を有する新規抗菌薬の同定と開発
- Author(s)
  浜本洋、石井健一、安川淳一朗、西田智、関水和久
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県神戸市）
- Year and Date
  2015-03-26 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] Silkworm as an animal model for novel antibiotic development
- Author(s)
  Hiroshi Hamamoto, Jyunichiro Yasukawa, Kenich Ishii, Atmika Paudel, Kazuhisa Sekimizu
- Organizer
  the Xth European Congress of Entomology
- Place of Presentation
  York（England）
- Year and Date
  2014-08-03 – 2014-08-08
- Invited
- Data Source
  KAKENHI-PUBLICLY-26102714
[Presentation] Comprehensive gene expression analysis for Staphylococcus aureus infected in kidney
- Author(s)
  Hiroshi Hamamoto, Suguru Ohgi, Yutaka Suzuki, Kazuhisa Sekimizu
- Organizer
  International Symposium on Genome Science 2015　“Expanding Frontiers of Genome Science II
- Place of Presentation
  一ツ橋ホール（東京都千代田区）
- Year and Date
  2015-01-20 – 2015-01-21
- Data Source
  KAKENHI-PROJECT-24689008

1. SEKIMIZU Kazuhisa (90126095)

# of Collaborated Projects: 3 results

# of Collaborated Products: 56 results
2. Yukitake Hideharu (30380984)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 庄子幹郎 (10336175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 内藤真理子 (20244072)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 垣内力 (60420238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 松本靖彦 (60508141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 宮下惇嗣 (40818308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. WANNIGAMA Dhammika Leshan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKATA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. Inoue Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 立石善隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 伊藤寛晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. 長友優典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAMAMOTO HIROSHI 浜本 洋

HAMAMOTO Hiroshi 浜本 洋

Research Projects

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メナキノンに着目した抗菌薬の殺菌作用の解明とより効果が高い併用療法の確立Principal Investigator

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Elucidation of the bactericidal mechanism involving menaquinone induction in novel antimicrobial therapeutics.Principal Investigator

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Mechanstic analysis of Lysosin E for Staphylococcus aureus biofilm infectionPrincipal Investigator

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歯周病原細菌の9型分泌機構における選択的分泌メカニズムの解明

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Elucidation of the lipoprotein transport mechanism specific to Bacteroidia bacteria such as periodontal pathogens

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Functional analysis of novel substances from food materials showing strong abilities of innate immunity stimulation

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Mechanism of action analysis of novel antibiotics in host factor contribution to therapeutic efficacyPrincipal Investigator

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Platform for the identification of novel therapeutically effective antimicrobial agents

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新規抗生物質カイコシンと、宿主由来活性促進因子との相互作用解析Principal Investigator

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Development of lead commands for new anti-infective agentsPrincipal Investigator

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Establishment of screening system for antifungal drugs using silkworm fungus infection model

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Establishment of a screening system for therapeutically effective antibioticsPrincipal Investigator

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Evaluation of pharmacokinetic using silkworm as an animal modelPrincipal Investigator

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HAMAMOTO HIROSHI 浜本洋

HAMAMOTO Hiroshi 浜本洋