Usui Takashi 臼井崇

… Alternative Names

USUI Takashi 臼井崇

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Researcher Number	90362483
Affiliation (Current)	2025: 京都大学, 医学研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2013 – 2015: 京都大学, 医学(系)研究科(研究院), その他 2011 – 2013: 京都大学, 医学(系)研究科(研究院), 非常勤講師 2012: 京都大学, 医学研究科, 非常勤講師 2012: 京都大学, 大学院・医学研究科, 非常勤講師 2011: 京都大学, 医学研究科, 准教授 … More 2010: 京都大学, 医学研究科, 特定准教授 2010: Kyoto University, 大学院・医学研究科, 特定准教授 2007 – 2009: 京都大学, 医学研究科, 准教授 2008: 京都大学, 大学院・医学研究科, 准教授 2007: Kyoto University, Faculty of Medicine, Assistant Professor 2004 – 2006: 京都大学, 医学研究科, 助手 2005: Kyoto University, Faculty of Medicine, Assistant Professor Less
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / Collagenous pathology/Allergology Except Principal Investigator 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator IFN-gamma / IL-17 / Th1 / 関節リウマチ / ヘルパーT細胞 / 自己免疫疾患 / Th17 / helper T cell / TGF-beta / レトロウイルス … More / STAT1 / STAT4 / T-bet / Th2 / エピゲノム制御 / マイクロアレイ / 間質性肺炎 / サイトカイン / gamma / 関節炎モデルマウス / arthritis model mouse / rheumatoid arthritis / autoimmune disease / delta T cell / 関節リマウチ / TGF-β / IL-10 / 制御性T細胞 / type II collagen / 細胞移入療法 / GM-CSF / 炎症 / ChiP解析 / エピジェネティック / ChiP 解析 / エピジェネティック制御 / 網羅的解析 / 細胞免疫療法 / 滑膜 / 膠原病 / CSF2 / 滑膜線維芽細胞 / 膠原病学 / コラーゲン誘導関節炎 / SKGマウス / ケモカイン / delta T細胞 … More Except Principal Investigator フォリスタチン関連蛋白 / FRP / カルパスタチン / カルパイン / 自己抗体 / 関節リウマチ / 破骨細胞 / サイトカイン / T細胞分化 / 炎症性ｻｲﾄｶｲﾝ / 自己免疫疾患 / Th17 細胞 / Th2バランス / Th1 / ホリスタチン関連蛋白 / CD4陽性T細胞 / IL-6 / コラーゲン誘発関節炎 Less

Epigenetic analysis of selective control of IL-17 production, and search for new strategy to treat chronic inflammation in collagen-diseases.Principal Investigator
- Principal Investigator
  
  Usui Takashi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Kyoto University
Comprehensive search for the new target to establish immunotherapy using SST-REX analysisPrincipal Investigator
- Principal Investigator
  
  UUSI Takashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University
A study on the development of new strategy to control inflammation using molecular mechanism of a IL-17 high-producing cell linePrincipal Investigator
- Principal Investigator
  
  USUI Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University
Analysis of pathogenicity and development of novel therapy byinflammation-regulating proteins in systemic autoimmune diseases
- Principal Investigator
  
  MIMORI Tsuneyo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University
Development of new anti-inflammatory compounds and/or biologics to achieve disease specific immune-regulationPrincipal Investigator
- Principal Investigator
  
  USUI Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University
Analysis of pathophysiology and novel therapeutic approach for rheumatic diseases by arthritis-regulated proteins
- Principal Investigator
  
  MIMORI Tsuneyo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University
Establishment of disease specific immunotherapy using specific antigen and immunoregulatory moleculePrincipal Investigator
- Principal Investigator
  
  USUI Takshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University
Trial of disease specific immunotherapy using antigen-specific T cells and immunoregulatory genes.Principal Investigator
- Principal Investigator
  
  USUI Takshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kyoto University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] A novel splice variant of human L-selectin encodes a soluble molecule that is elevated in serum of patients with rheumatic diseases2015
- Author(s)
  Hirata T, Usui T, Kobayashi S, Mimori T
- Journal Title
  
  Biochemical Biophysical Research Communications
  
  Volume: 462 Issue: 4 Pages: 371-377
- DOI
  10.1016/j.bbrc.2015.05.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460588, KAKENHI-PROJECT-26670476
[Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.2015
- Author(s)
  Shiomi A, Usui T, Ishikawa Y, Shimizu M, Murakami K, Mimori T.
- Journal Title
  
  J Immunol
  
  Volume: 193 Pages: 849-859
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670476
[Journal Article] Pivotal roles of GM-CSF in autoimmunity and inflammation.2015
- Author(s)
  Shiomi A, Usui T.
- Journal Title
  
  Mediators Inflamm
  
  Volume: 0 Issue: 1 Pages: 0-0
- DOI
  10.1155/2015/568543
- NAID
  120005745654
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670476
[Journal Article] Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/ IL-2Rγ-/- mice.2014
- Author(s)
  Ishikawa Y, Usui T, Shiomi A, Shimizu M, Murakami K, Mimori T
- Journal Title
  
  Eur J Immunol.
  
  Volume: 44(11) Issue: 11 Pages: 3453-3463
- DOI
  10.1002/eji.201444729
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293222, KAKENHI-PROJECT-26670476
[Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.2014
- Author(s)
  Shiomi A, Usui T, Ishikawa Y, Shimizu M, Murakami K, Mimori T
- Journal Title
  
  J Immunol
  
  Volume: 193(2) Issue: 2 Pages: 849-859
- DOI
  10.4049/jimmunol.1303255
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293222, KAKENHI-PROJECT-26670476
[Journal Article] Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases2014
- Author(s)
  Tanaka K, Terao C, Ohmura K, Takahashi M, Nakashima R, Imura Y, Yoshifuji H, Yukawa N, Usui T, Fujii T, Mimori T, Matsuda F
- Journal Title
  
  J Hum Genet
  
  Volume: 59(2) Pages: 107-9
- NAID
  120005587802
- Data Source
  KAKENHI-PROJECT-23390258
[Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice2014
- Author(s)
  Aoi Shiomi, Takashi Usui, Yuki Ishikawa, Masakazu Shimizu, Kosaku Murakami, and Tsuneyo Mimori
- Journal Title
  
  The Journal of Immunology
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390258
[Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice2014
- Author(s)
  Aoi Shiomi, Takashi Usui, Yuki Ishikawa, Masakazu Shimizu, Kosaku Murakami, and Tsuneyo Mimori
- Journal Title
  
  J Immunol
- Data Source
  KAKENHI-PROJECT-23390258
[Journal Article] Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database2013
- Author(s)
  Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T
- Journal Title
  
  PLoS One
  
  Volume: 8(3) Issue: 3 Pages: e59341-e59341
- DOI
  10.1371/journal.pone.0059341
- NAID
  120005244457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390258, KAKENHI-PROJECT-23590379, KAKENHI-PROJECT-23659719, KAKENHI-PROJECT-23791112, KAKENHI-PROJECT-23791113, KAKENHI-PROJECT-24659274
[Journal Article] Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 1 7, 000 assessments in the KURAMA database2013
- Author(s)
  Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- NAID
  120005244457
- Data Source
  KAKENHI-PROJECT-23390258
[Journal Article] Three Groups in the 28 Joints for Rheumatoid Arthritis Synovitis - Analysis Using More than 17,000 Assessments in the KURAMA Database.2013
- Author(s)
  Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, Yamakawa N, Yoshifuji H, Yukawa N, Kawabata D, Usui T, Yoshitomi H, Furu M, Yamada R, Matsuda F, Ito H, Fujii T, Mimori T
- Journal Title
  
  PLoS One
  
  Volume: 8(3)
- NAID
  120005244457
- Data Source
  KAKENHI-PROJECT-23659500
[Journal Article] Follistatin-related protein/ follistatinlike 1 evokes an innate immune response via CD14 and toll- like receptor 4.2012
- Author(s)
  Murakami K, Tanaka M, Usui T, Kawabata D, Shiomi A, Iguchi-Hashimoto M, Shimizu M, Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Mimori T
- Journal Title
  
  FEBS Lett.
  
  Volume: 586(4) Issue: 4 Pages: 319-24
- DOI
  10.1016/j.febslet.2012.01.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390201, KAKENHI-PROJECT-22591091, KAKENHI-PROJECT-23791112
[Journal Article] NEFA/nucleobindin-2 is a target autoantigen of the anti-Wa antibody and is associated with transfer RNA2012
- Author(s)
  Imura Y, Shirai Y, Nojima T, Nakashima R, Yamagata H, Miyachi K, Yoshifuji H, Kawabata D, Ohmura K, Usui T, Fujii T, Mimori T
- Journal Title
  
  Mod Rheumatol
  
  Volume: 22(5) Pages: 685-94
- NAID
  10031027691
- Data Source
  KAKENHI-PROJECT-23659500
[Journal Article] Follistatin-related protein /follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor42012
- Author(s)
  Murakami K, Tanaka M, Usui T, Kawabata D, Shiomi A, Iguchi-Hashimoto M, Shimizu M, Yukawa N, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Umehara H, Mimori T
- Journal Title
  
  FEBS Lett
  
  Volume: 586(4) Pages: 319-24
- Data Source
  KAKENHI-PROJECT-23659500
[Journal Article] NEFA/nucleobindin-2 is a target autoantigen of the anti-Wa antibody and is associated with transfer RNA.2012
- Author(s)
  Imura Y , Shirai Y , Nojima T, Nakashima R, Yamagata H, Miyachi K, Yoshifuji H, Kawabata D, Ohmura K, Usui T, Fujii T, Mimori T
- Journal Title
  
  Mod Rheumatol
  
  Volume: 22(5) Issue: 5 Pages: 685-94
- DOI
  10.1007/s10165-011-0582-9
- NAID
  120005054563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390201, KAKENHI-PROJECT-22790942
[Journal Article] Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF- κB and increased STAT5 signals2011
- Author(s)
  Iguchi-Hashimoto M, Usui T, Yoshifuji H, Shimizu M, Kobayashi S, Ito Y, Murakami K, Shiomi A, Yukawa N, Kawabata D, Nojima T, Ohmura K, Fujii T, Mimori T
- Journal Title
  
  PLoS One
  
  Volume: 6(10)
- Data Source
  KAKENHI-PROJECT-23659500
[Journal Article] Interferon-gamma release assay for diagnosing Mycobacterium tuberculosis infections in patients with systemic lupus erythematosus2011
- Author(s)
  Takeda N, Nojima T, Terao C, Yukawa N, Kawabata D, Ohmura K, Usui T, Fujii T, Ito Y, Iinuma Y, Mimori T
- Journal Title
  
  Lupus
  
  Volume: 20(8) Pages: 792-800
- Data Source
  KAKENHI-PROJECT-23659500
[Journal Article] Overexpression of minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-kB and increased STAT5 signals.2011
- Author(s)
  Iguchi-Hashimoto M, Usui T, Yoshifuji H, Shimizu M, Kobayashi S, Ito Y, Murakami K, Shiomi A, Yukawa N, Kawabata D, Nojima T, Ohmura K, Fujii T, Mimori T
- Journal Title
  
  PLoS ONE
  
  Volume: 6(10) Issue: 10 Pages: e27020-e27020
- DOI
  10.1371/journal.pone.0027020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390201, KAKENHI-PROJECT-23791112
[Journal Article] A case of antisynthetase syndrome in a rheumatoid arthritis patient with anti-PL-12 antibody following treatment with etanercept2011
- Author(s)
  Ishikawa Y, Yukawa N, Kawabata D, Ohmura K, Fujii T, Usui T, Mimori T
- Journal Title
  
  Clin Rheumatol
  
  Volume: 30(3) Pages: 429-32
- NAID
  120003039177
- Data Source
  KAKENHI-PROJECT-23659500
[Journal Article] Correlation of antinuclear antibody and anti-double-stranded DNA antibody with clinical response to infliximab in patients with rheumatoid arthritis: a retrospective clinical study2011
- Author(s)
  Yukawa N, Fujii T, Kondo-Ishikawa S, Yoshifuji H, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 13(6)
- NAID
  120004754356
- Data Source
  KAKENHI-PROJECT-23659500
[Journal Article] Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men2010
- Author(s)
  Yokoyama T, Usui T, Kiyama K, Nakashima R, Yukawa N, Kawabata D, Nojima T, Ohmura K, Fujii T, Mimori T.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 20 Pages: 405-9
- NAID
  10026691598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] RAにおけるTh17細胞とIL-17.2010
- Author(s)
  臼井崇
- Journal Title
  
  Frontiers in Rheumatology & Clinical Immunology. 第4巻
  
  Pages: 162-5
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1 -analysis of their binding with TGF-β superfamily proteins.2010
- Author(s)
  Tanaka M, Murakami K, Ozaki S, Imura Y, Tong XP, Watanabe T, Sawaki T, Kawanami T, Kawabata D, Fujii T, Usui T, Masaki Y, Fukushima T, Jin ZX, Umehara H, Mimori T
- Journal Title
  
  FEBS J. 277(20)
  
  Pages: 4278-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1-analysis of their binding with TGF-β superfamily proteins.2010
- Author(s)
  Tanaka M, Murakami K, Ozaki S, Imura Y, Tong XP, Watanabe T, Sawaki T, Kawanami T, Kawabata D, Fujii T, Usui T, Masaki Y, Fukushima T, Jin ZX, Umehara H, Mimori T.
- Journal Title
  
  FEBS J
  
  Volume: 277 Pages: 4278-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Etanercept-induced anti-Jo-1-antibody-positive polymyositis in a patient with rheumatoid arthritis : a case report and review of the literature2010
- Author(s)
  Ishikawa Y, Yukawa N, Ohmura K, Hosono Y, Imura Y, Kawabato D, Nojima T, Fujii T, Usui T, Mimori T.
- Journal Title
  
  Clin Rheumatol
  
  Volume: 29 Pages: 563-6
- NAID
  120002191883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.2010
- Author(s)
  Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T.
- Journal Title
  
  Rheumatology
  
  Volume: 49 Pages: 433-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.2010
- Author(s)
  Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T.
- Journal Title
  
  Rheumatology (Oxford). 49(3)
  
  Pages: 433-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] 関節リウマチ患者関節液中のIL-17Aの役割2010
- Author(s)
  臼井崇
- Journal Title
  
  リウマチ科
  
  Volume: 43 Pages: 394-401
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.2010
- Author(s)
  Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T
- Journal Title
  
  Arthritis Rheum. 62(12)
  
  Pages: 3730-40
- NAID
  120005593598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Periodic fever and erythema nodosum associated with MDS with trisomy 8 : report of two cases and review of the literature.2010
- Author(s)
  Fujimura T, Yukawa N, Nakashima R, Imura Y, Kawabata D, Nojima T, Ohmura K, Fujii T, Usui T, Mimori T
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 20 Pages: 413-9
- NAID
  10026691630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.2010
- Author(s)
  Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T.
- Journal Title
  
  Arthritis Rheum
  
  Volume: 62 Pages: 3730-40
- NAID
  120005593598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] RAにおけるTh17細胞とIL-172010
- Author(s)
  臼井崇
- Journal Title
  
  Frontiers in Rheumatology & Clinical Immunolog
  
  Volume: 4 Pages: 162-5
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] DIP2 disco-interacting protein 2 homolog A (Drosophilla) is a candidate receptor for follistatin-related protein/follistatin-like 1. Analysis of their binding with TGF-βsuperfamily proteins.2010
- Author(s)
  Tanaka M, Murakami K, Ozaki S, Imura Y, Tong XP, Watanabe T, Sawaki T, Kawanami T, Kawabata D, Fujii T, Usui T, Masaki Y, Fukushima T, Jin ZX, Umehara H, Mimori T
- Journal Title
  
  FEBS J.
  
  Volume: 277(20) Issue: 20 Pages: 4278-89
- DOI
  10.1111/j.1742-4658.2010.07816.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390201
[Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.2010
- Author(s)
  Sato T, Fujii T, Yokoyama T , Fujita Y , Imura Y , Yukawa N, Kawabata D, Nojima N, Ohmura K, Usui T, Mimori T
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 62(12) Issue: 12 Pages: 3730-40
- DOI
  10.1002/art.27700
- NAID
  120005593598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390201, KAKENHI-PROJECT-22591091
[Journal Article] 関節リウマチ患者関節液中のIL-17Aの役割2010
- Author(s)
  臼井崇
- Journal Title
  
  リウマチ科第43巻
  
  Pages: 394-401
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Leukoencephalopathy with cognitive impairment following tocilizumab for the treatment of rheumatoid arthritis (RA)2009
- Author(s)
  Kobayashi K, Okamoto Y, Inoue H, Usui T, et al.
- Journal Title
  
  Intern Med 48
  
  Pages: 1307-1309
- NAID
  130000121960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.2009
- Author(s)
  Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T.
- Journal Title
  
  Arthritis Rheum. 60(8)
  
  Pages: 2294-303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] γδT Cells Are the Predominant Source of IL-17 in the Affected Joints of Collagen-Induced Arthritis, but Not in Rheumatoid Arthritis2009
- Author(s)
  Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Hashimoto M, Sakaguchi N, Sakaguchi S, Shimizu M, Yoshifuji H, Nojima T, Ohmura K, Kawabata D, Fujii T, Mimori T.
- Journal Title
  
  Arthritis Rheum. 30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591106
[Journal Article] y δT cells are predominant source of IL-17 in the affected joints of collagen-induced arthritis, but not in rheumatoid arthritis2009
- Author(s)
  Ito Y, Usui T, Fujii T, Mimori T, et al
- Journal Title
  
  Arthritis Rheum (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390290
[Journal Article] Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice2009
- Author(s)
  Sasaki N, Yamashita T, Takeda M, Shinohara M, Nakajima K, Tawa H, Usui T, et al.
- Journal Title
  
  Circulation 120
  
  Pages: 1996-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Autoimmune autonomic ganglionopathy with Sjogren's syndrome : Significance of ganglionic acetylcholine receptor antibody and therapeutic approach2009
- Author(s)
  Kondo T, Inoue H, Usui T, Mimori T, Tomimoto H, Vernino S, Takahashi R
- Journal Title
  
  Auton Neurosci. Auton Neurosci 146(1-2)
  
  Pages: 33-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390290
[Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis2009
- Author(s)
  Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T.
- Journal Title
  
  Arthritis Rheum 60
  
  Pages: 2294-303
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591106
[Journal Article] γδ T Cells Are the Predominant Source of IL-17 in the Affected Joints of Collagen-Induced Arthritis, but Not in Rheumatoid Arthritis2009
- Author(s)
  Ito Y, Usui T, et al.
- Journal Title
  
  Arthritis Rheum 30
  
  Pages: 2294-2303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Vaccination with autoreactive CD4(+)Th1 clones in lupus-prone MRL/Mp-Fas(lpr/lpr)mice2009
- Author(s)
  Fujii T, Okada M, Fujita Y, Sato T, Tanaka M, Usui T, Umehara H, Mimori T.
- Journal Title
  
  J Autoimmun 33
  
  Pages: 125-34
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591106
[Journal Article] Vaccination with autoreactive CD4(+)Th1 clones in lupus-prone MRL/Mp-Fas(lprlpr) mice2009
- Author(s)
  Fujii T, Okada M, Fujita Y, Sato T, Tanaka M, Usui T, et al.
- Journal Title
  
  J Autoimmun 33
  
  Pages: 125-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Autoimmune autonomic ganglionopathy with Sjogren's syndrome : significance of ganglionic acetylcholine receptor antibody and therapeutic approach2009
- Author(s)
  Kondo T, Inoue H, Usui T, et al.
- Journal Title
  
  Auton Neurosci 146
  
  Pages: 33-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Vaccination with autoreactive CD4(+)Th1 clones in lupus-prone MRL/Mp-Fas(lpr/lpr)mice2009
- Author(s)
  Fujii T, Okada M, Fujita Y, Sato T, Tanaka M, Usui T, Umehara H, Mimori T
- Journal Title
  
  J Autoimmun. 33(2)
  
  Pages: 125-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591106
[Journal Article] gamma/delta T Cells Are the Predominant Source of IL-17 in the Affected Joints of Collagen-Induced Arthritis, but Not in Rheumatoid Arthritis2009
- Author(s)
  Ito Y, 0Usui T, et al.
- Journal Title
  
  Arthritis & Rheumatism
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591168
[Journal Article] Severe subcutaneous generalized edema in a patient with dermatomyositis2007
- Author(s)
  Ito Y, Kawabata D, Yukawa N, Yoshifuji H, Usui T, Tanaka M, Fujii T, Mimori T.
- Journal Title
  
  Mod Rheumatol 17
  
  Pages: 171-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591106
[Journal Article] Successful treatment of a patient with refractory adult Still's disease by tacrolimus2007
- Author(s)
  Murakami K, Fujii T, Yukawa N, Yoshifuji H, Kawabata D, Tanaka M, Usui T, Mimori T
- Journal Title
  
  Mod Rheumatol 17(2)
  
  Pages: 167-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390290
[Journal Article] Successful treatment of a patient with refractory adult Still's disease by tacrolimus2007
- Author(s)
  Murakami K, Fujii T, Yukawa N, Yoshifuji H, Kawabata D, Tanaka M, Usui T, Mimori
- Journal Title
  
  Mod Rheumatol 17
  
  Pages: 167-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591106
[Journal Article] Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopatc inflammatory myopathies2007
- Author(s)
  Yoshifuji H, Fujii T, Kobayashi S, Imura Y, Fujita Y, Kawabata D, Usui T, Tanaka M, Nagai S, Umehara H, Mimori T.
- Journal Title
  
  Autoimmunity 39
  
  Pages: 233-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591106
[Journal Article] Severe subcutaneous generalized edema in a patient with dermatomyositis2007
- Author(s)
  Ito Y, Kawabata D, Yukawa N, Yoshifuji H, Usui T, Tanaka M, Fujii T, Mimori T
- Journal Title
  
  Mod Rheumatol 17(2)
  
  Pages: 171-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390290
[Journal Article] T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription2006
- Author(s)
  Usui T
- Journal Title
  
  J Exp Med. 203(3)
  
  Pages: 755-766
- Data Source
  KAKENHI-PROJECT-18591106
[Journal Article] T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription2006
- Author(s)
  Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'Shea JJ, Strober W.
- Journal Title
  
  J Exp Med 203
  
  Pages: 755-66
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590980
[Journal Article] Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies2006
- Author(s)
  Yoshifuji H, Fujii T, Kobayashi S, Imura Y, Fujita Y, Kawabata D, Usui T, Tanaka M, Nagai S, Umehara H, Mimori T
- Journal Title
  
  Autoimmunity 39(3)
  
  Pages: 233-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390290
[Journal Article] T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.2006
- Author(s)
  Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'shea JJ, Strober W.
- Journal Title
  
  J Exp Med. 203(3)
  
  Pages: 755-766
- Data Source
  KAKENHI-PROJECT-16590980
[Journal Article] Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies2006
- Author(s)
  Yoshifuji H, Fujii T, Kobayashi S, Imura Y, Fujita Y, Kawabata D, Usui T, Tanaka M, Nagai S, Umehara H, Mimori T
- Journal Title
  
  Autoimmunity 39
  
  Pages: 233-41
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16590980
[Journal Article] T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription2006
- Author(s)
  Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'Shea JJ, Strober W.
- Journal Title
  
  J Exp Med. 203(3)
  
  Pages: 755-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590980
[Journal Article] Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies2006
- Author(s)
  Yoshifuji H, Fujii T, Kobayashi S, Imura Y, Fujita Y, Kawabata D, Usui T, Tanaka M, Nagai S, Umehara H, Mimori T.
- Journal Title
  
  Autoimmunity 39(3)
  
  Pages: 233-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590980
[Journal Article] γδT Cells are the predominant source of IL-17 in the affected joints of collagen-induced arthritis, but not in rheumatoid arthritis
- Author(s)
  Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T
- Journal Title
  
  Arthritis Rheum (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390290
[Presentation] GM-CSFと自己免疫疾患：関節炎合併間質性肺炎モデルを中心に2015
- Author(s)
  塩見　　葵，臼井　　宗，三森　経世
- Organizer
  第36回日本炎症・再生医学会
- Place of Presentation
  東京
- Year and Date
  2015-07-21
- Invited
- Data Source
  KAKENHI-PROJECT-26670476
[Presentation] Follistatin-related protein(FRP/FSTL1) exacerbates the inflammatoryprocess of arthritis.2011
- Author(s)
  Murakami K, Tanaka M, Usui T, Kawabata D, Shiomi A, Iguchi-Hashimoto M, Shimizu M,Yukawa N, Yoshifuji H, Ohmura K, Fujii T, Umehara H, Mimori T
- Organizer
  European League Against Rheumatism (EULAR 2011)
- Place of Presentation
  London
- Data Source
  KAKENHI-PROJECT-22390201
[Presentation] A New ELISA System for Detecting Autoantibodies to aminoacyl-tRNA Synthetases : Usefulness in Myositis and Interstitial Pneumonia.2010
- Author(s)
  Ran Nakashima, Yoshitaka Imura, Shio Kobayashi, Yuji Hosono, Naoichiro Yukawa, Daisuke Kawabata, Takaki Nojima, Koichiro Ohmura, Takashi Usui, Takao Fujii, Minae Seto, Akihiro Murakami, Tsuneyo Mimori
- Organizer
  米国リウマチ学会
- Place of Presentation
  Atlanta.U.S.A.
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-20591168
[Presentation] CORRELATION OF ANTINUCLEAR ANTIBODIES AND ANTI-DNA ANTIBODIES WITH CLINICAL RESPONSE TO INFLIXIMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS2010
- Author(s)
  N.Yukawa, T.Fujii, D.Kawabata, T.Nojima, K.Ohmura, T.Usui, T.Mimori
- Organizer
  欧州リウマチ学会
- Place of Presentation
  Rome, Italy
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-20591168
[Presentation] IL-17は関節リウマチのバイオマーカーとなりえるか?標的となりえるか?2009
- Author(s)
  臼井崇
- Organizer
  第74回日本インターフェロン・サイトカイン学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-06-27
- Data Source
  KAKENHI-PROJECT-20591168
[Presentation] リウマチ性疾患の検査血清IL-17F値は関節リウマチの新規バイオマーカーである2009
- Author(s)
  小林志緒, 臼井崇, 伊藤能永, 橋本美季子, 吉藤元, 清水正和, 湯川尚一郎, 川端大介, 野島崇樹, 大村浩一郎, 藤井隆夫, 三森経世.
- Organizer
  第53回日本リウマチ学会
- Place of Presentation
  東京
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-20591168
[Presentation] γδ T cells are the predominant IL-17-producing cells in affected joints of collagen-induced arthritis2008
- Author(s)
  Ito Y, Usui T, Kobayashi S, Iguch M, Ito H, Yoshitomi H, Nakamura T, Hashimoto M, Sakaguchi N, Sakaguchi S, Mimori T
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591106
[Presentation] Translational research in immunology Biology of TGF-b and IL-17s in Translational Research.2008
- Author(s)
  臼井崇, 小林志緒, 伊藤能永, 橋本美季子, 村上孝作, 三森経世
- Organizer
  第52回日本リウマチ学会
- Place of Presentation
  札幌
- Year and Date
  2008-04-22
- Data Source
  KAKENHI-PROJECT-20591168
[Presentation] TGF-beta and IL-17s in translational research2008
- Author(s)
  Usui T
- Organizer
  第38回日本免疫学会・国際シンポジウム
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-20591168
[Presentation] 膠原病における血清中IL-17F値の測定とその意義に関する解析2008
- Author(s)
  小林志緒, 臼井崇, 橋本美季子, 村上孝作, 湯川尚一郎, 川端大介, 野島崇樹, 大村浩一郎, 藤井隆夫, 三森経世
- Organizer
  第38回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20591168
[Presentation] II型コラーゲン誘発性関節炎(CIA)局所におけるIL-17分泌細胞の解析2008
- Author(s)
  伊藤能永, 臼井崇, 橋本美季子, 小林志緒, 吉藤元, 三森経世
- Organizer
  第52回日本リウマチ学会
- Place of Presentation
  札幌
- Year and Date
  2008-04-23
- Data Source
  KAKENHI-PROJECT-20591168
[Presentation] γδT cells are the predominant IL-17-producing cells in affected joints of collagen-induced arthritis2008
- Author(s)
  Ito Y, Usui T, Kobayashi S, Iguch M, Ito H, Yoshitomi H, Nakamura T, Hashimoto M, Sakaguchi N, Sakaguchi S, Mimori T.
- Organizer
  The 38^<th> Annual Meeting of the Japanese society of immunology
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2008-12-03
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591106
[Presentation] Follistatin-related protein (FRP)/FSTL1 is one ofthe regulators of IL-6 production in fibroblast-derived cell lines2008
- Author(s)
  Murakami K, Tanaka M, Usui T, Mimori T
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-18390290
[Presentation] Ameriolation of experimental myositis by a calpain-inhibitory compound.2007
- Author(s)
  Yoshifuji H, Usui H, Itoh Y, Hashimoto M, Mimori T
- Organizer
  The 71th Annual Meeting of the American College of Rheumatology
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PROJECT-18390290
[Presentation] 疾患特異的な免疫制御法の開発の可能性2007
- Author(s)
  臼井崇
- Organizer
  第51回日本リウマチ学会総会・学術集会・シンポジウム10(関節リウマチの新たなる治療ターゲット〜生物学的製剤を超えて〜)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-04-28
- Data Source
  KAKENHI-PROJECT-18591106
[Presentation] 疾患特異的な免疫制御法の可能性.2007
- Author(s)
  臼井崇、藤井隆夫、三森経世, ほか
- Organizer
  第51回日本リウマチ学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18390290

1. MIMORI Tsuneyo (10157589)

# of Collaborated Projects: 5 results

# of Collaborated Products: 47 results
2. FUJII Takao (70255462)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. TANAKA Masao (10332719)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. WAKATSUKI Yoshio (40220826)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. NISHIKOMORI Ryuta (70359800)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. MURAKLAMI Kosaku

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OHMURA Koichiro (40432372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. NOJIMA Takaki (30327514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. ITO Yoshinaga

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. HASHIMOTO Mikiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. IGUCHI Mikiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 平田多佳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Usui Takashi 臼井 崇

USUI Takashi 臼井 崇

Research Projects

Research Products

Co-Researchers

Epigenetic analysis of selective control of IL-17 production, and search for new strategy to treat chronic inflammation in collagen-diseases.Principal Investigator

Principal Investigator

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Comprehensive search for the new target to establish immunotherapy using SST-REX analysisPrincipal Investigator

Principal Investigator

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A study on the development of new strategy to control inflammation using molecular mechanism of a IL-17 high-producing cell linePrincipal Investigator

Principal Investigator

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Research Institution

Analysis of pathogenicity and development of novel therapy byinflammation-regulating proteins in systemic autoimmune diseases

Principal Investigator

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Development of new anti-inflammatory compounds and/or biologics to achieve disease specific immune-regulationPrincipal Investigator

Principal Investigator

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Research Institution

Analysis of pathophysiology and novel therapeutic approach for rheumatic diseases by arthritis-regulated proteins

Principal Investigator

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Establishment of disease specific immunotherapy using specific antigen and immunoregulatory moleculePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Trial of disease specific immunotherapy using antigen-specific T cells and immunoregulatory genes.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] A novel splice variant of human L-selectin encodes a soluble molecule that is elevated in serum of patients with rheumatic diseases2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.2015

Author(s)

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Data Source

[Journal Article] Pivotal roles of GM-CSF in autoimmunity and inflammation.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/ IL-2Rγ-/- mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases2014

Author(s)

Usui Takashi 臼井崇

USUI Takashi 臼井崇