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Morita Hideaki  森田 英明

… Alternative Names

MORITA Hideaki  森田 英明

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Researcher Number 90365320
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-0928-8322
Affiliation (Current) 2025: 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 室長
Affiliation (based on the past Project Information) *help 2018 – 2024: 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 室長
2014: 独立行政法人国立成育医療研究センター, その他部局等, 研究員
2014: 独立行政法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 研究員
2013: 独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 54020:Connective tissue disease and allergy-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 08030:Family and consumer sciences, and culture and living-related / Collagenous pathology/Allergology
Except Principal Investigator
Basic Section 56040:Obstetrics and gynecology-related / Basic Section 54020:Connective tissue disease and allergy-related
Keywords
Principal Investigator
アレルギー / タフト細胞 / 気管支喘息 / 好酸球 / アレルギー性炎症 / 埃 / 環境塵 / 界面活性剤 / 2型自然リンパ球 / 自然リンパ球 … More / 微生物叢 / プロテアーゼ / 自然免疫リンパ球 / 制御性T細胞 / マスト細胞 / IL-33 / 気道炎症 … More
Except Principal Investigator
上流解析 / 網羅的遺伝子発現解析 / CTBサブタイプ / 細胞融合 / トロフォブラスト / CGA / ERVFRD-1 / CD49f / Annexin V / 合胞体栄養細胞 / 細胞性栄養細胞 / BMP4 / Syncytin2 / CXCR6 / human trophoblast / Cell fusions / マウスモデル / 皮膚炎 / 喘息 / サイトカイン / 気管支喘息 / アレルギー Less
  • Research Projects

    (7 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (9 People)
  •  Mechanisms of tuft cell-mediated inflammationPrincipal Investigator

    • Principal Investigator
      森田 英明
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      National Center for Child Health and Development
  •  細胞性トロフォブラストサブタイプによる、トロフォブラスト融合メカニズムの解明

    • Principal Investigator
      田邉 裕美
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      National Center for Child Health and Development
  •  Mechanism of taste components-induced inflammationPrincipal Investigator

    • Principal Investigator
      Morita Hideaki
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      National Center for Child Health and Development
  •  Elucidation of molecular mechanisms for development of allergic diseases via epithelial-dendritic cell networks

    • Principal Investigator
      Nakae Susumu
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Hiroshima University
  •  Elucidation of the effects of surfactants in environmental dust on the development of allergic diseasesPrincipal Investigator

    • Principal Investigator
      Morita Hideaki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 08030:Family and consumer sciences, and culture and living-related
    • Research Institution
      National Center for Child Health and Development
  •  Regulation of type 2 innate lymphoid cells by microbiotaPrincipal Investigator

    • Principal Investigator
      Morita Hideaki
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      National Center for Child Health and Development
  •  Mechanisms of non atopic airway inflammationPrincipal Investigator

    • Principal Investigator
      MORITA Hideaki
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      National Research Institute for Child Health and Development

All 2024 2023 2022 2021 2020 2019 2018 2015 2014 2013

All Journal Article Presentation Book

  • [Book] 細胞死によるアレルギー疾患への影響2013

    • Author(s)
      海野浩寿、森田英明、新江賢、大野建洲、斎藤博久、松本健治、中江進む
    • Total Pages
      6
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-25860822
  • [Book] 慢性アレルギー炎症のメカニズム2013

    • Author(s)
      斎藤博久、森田英明, 松本健治, 中江 進
    • Total Pages
      6
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-25860822
  • [Journal Article] The Prostaglandin D2 Receptor CRTH2 Contributes to Airway Hyperresponsiveness during Airway Inflammation Induced by Sensitization without an Adjuvant in Mice2024

    • Author(s)
      Hanzawa Satoshi、Sugiura Makiko、Nakae Susumu、Masuo Masahiro、Morita Hideaki、Matsumoto Kenji、Takeda Kazuyoshi、Okumura Ko、Nakamura Masataka、Ohno Tatsukuni、Miyazaki Yasunari
    • Journal Title

      International Archives of Allergy and Immunology

      Volume: - Issue: 8 Pages: 1-9

    • DOI

      10.1159/000537840

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02963
  • [Journal Article] Heterogeneity of food protein-induced enterocolitis syndrome (FPIES)2024

    • Author(s)
      Akashi M, Kaburagi S, Kajita N, Morita H
    • Journal Title

      Allergol. Int.

      Volume: 73 Issue: 2 Pages: 196-205

    • DOI

      10.1016/j.alit.2024.02.001

    • ISSN
      1323-8930, 1440-1592
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K27638
  • [Journal Article] Laundry detergents and surfactants induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s2023

    • Author(s)
      Saito K, Orimo K, Kubo T, Tamari M, Yamada A, Motomura K, Sugiyama H, Matsuoka R, Nagano N, Hayashi Y, Arae K, Hara M, Ikutani M, Fukuie T, Sudo K, Matsuda A, Ohya Y, Fujieda S, Saito H, Nakae S, Matsumoto K, Akdis CA, Morita H.
    • Journal Title

      Allergy

      Volume: - Issue: 7 Pages: 1878-1892

    • DOI

      10.1111/all.15762

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H01622, KAKENHI-PROJECT-21K08465, KAKENHI-PROJECT-21H02963
  • [Journal Article] Comprehensive Analysis of the Expression and Functions of Pattern Recognition Receptors in Differentiated Cytotrophoblasts Derived from Term Human Placentas2023

    • Author(s)
      Motomura Kenichiro、Morita Hideaki、Okada Naoko、Matsuda Akio、Nakae Susumu、Fujieda Mikiya、Sago Haruhiko、Saito Hirohisa、Matsumoto Kenji
    • Journal Title

      The Journal of Immunology

      Volume: 210 Issue: 10 Pages: 1552-1563

    • DOI

      10.4049/jimmunol.2300008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K08570, KAKENHI-PROJECT-23K08813, KAKENHI-PROJECT-22K20982, KAKENHI-PROJECT-21H02963
  • [Journal Article] Immune checkpoint molecules on ILC2s as potential therapeutic targets for allergic diseases2022

    • Author(s)
      Hideaki Morita, Hirohisa Saito, Kenji Matsumoto
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 149 Issue: 1 Pages: 60-62

    • DOI

      10.1016/j.jaci.2021.10.021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H01622
  • [Journal Article] New insights into human atopic dermatitis provided by mouse models2021

    • Author(s)
      Matsumoto Kenji、Morita Hideaki、Nakae Susumu
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 148 Issue: 3 Pages: 722-724

    • DOI

      10.1016/j.jaci.2021.07.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21H02963
  • [Journal Article] Direct platelet adhesion potentiates group 2 innate lymphoid cell functions2021

    • Author(s)
      Orimo Keisuke, et.al
    • Journal Title

      Allergy

      Volume: 77 Issue: 3 Pages: 843-855

    • DOI

      10.1111/all.15057

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07632, KAKENHI-PROJECT-21H02963
  • [Journal Article] Allergic Rhinitis: What Do We Know About Allergen-Specific Immunotherapy?2021

    • Author(s)
      Tadech Boonpiyathad, Mongkol Lao-Araya, Chirawat Chiewchalermsri, Sasipa Sangkanjanavanich, Hideaki Morita
    • Journal Title

      Frontier Allergy

      Volume: -

    • DOI

      10.3389/falgy.2021.747323

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H01622
  • [Journal Article] Characteristics of tissue-resident ILCs and their potential as therapeutic targets in mucosal and skin inflammatory diseases2021

    • Author(s)
      Keisuke Orimo, Masato Tamari, Hirohisa Saito, Kenji Matsumoto, Susumu Nakae, Hideaki Morita
    • Journal Title

      Allergy

      Volume: - Issue: 11 Pages: 3332-3348

    • DOI

      10.1111/all.14863

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H01622, KAKENHI-PROJECT-19K17692, KAKENHI-PROJECT-21H02963
  • [Journal Article] Innate lymphoid cells in the airways: Their functions and regulators.2020

    • Author(s)
      Orimo K, Saito H, Matsumoto K, Morita H.
    • Journal Title

      Allergy Asthma Immunol Res.

      Volume: 12 Issue: 3 Pages: 381-398

    • DOI

      10.4168/aair.2020.12.3.381

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K16167, KAKENHI-PROJECT-19K17692
  • [Journal Article] Gene expression signatures of circulating human type 1, 2 and 3 innate lymphoid cells.2019

    • Author(s)
      Li S, Morita H, Sokolowska M, Tan G, Boonpiyathad T, Opitz L, Orimo K, Archer SK, Jansen K, Tang MLK, Purcell D, Plebanski M, Akdis CA.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 143 Issue: 6 Pages: 2321-2325

    • DOI

      10.1016/j.jaci.2019.01.047

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16167
  • [Journal Article] Human type 2 innate lymphoid cells disrupt skin keratinocyte tight junction barrier by IL-132019

    • Author(s)
      Sugita K, Altunbulakli C, Morita H, Sugita A, Kubo T, Kimura R, Goto H, Yamamoto O, Rückert B, Akdis M, Akdis CA.
    • Journal Title

      Allergy

      Volume: 74 Issue: 12 Pages: 2534-2537

    • DOI

      10.1111/all.13935

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08268, KAKENHI-PROJECT-18K16167
  • [Journal Article] Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid2019

    • Author(s)
      Morita H, Kubo T, Ruckert B, Ravindran A, Soyka M, Rinaldi A, Sugita K, Wawrzyniak M, Wawrzyniak P, Motomura K, Tamari M, Orimo K, Okada N, Arae K, Saito K, Altunbulakli C, Castro-Giner F, Tan G, Neumann A, Sudo K, O’Mahony L, Honda K, Nakae S, Saito H, Mjösberg J, Nilsson G, Matsumoto K, Akdis M, Akdis CA
    • Journal Title

      J Allergy Clin Immunol.

      Volume: in press Issue: 6 Pages: 2190-2201

    • DOI

      10.1016/j.jaci.2018.12.1018

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16167, KAKENHI-PROJECT-18K08395, KAKENHI-PROJECT-18H02847, KAKENHI-PROJECT-17K11500
  • [Journal Article] Chitin promotes antigen-specific Th2 cell-mediated murine asthma through induction of IL-33-mediated IL-1β production by DCs2018

    • Author(s)
      Arae Ken、Morita Hideaki、Unno Hirotoshi、Motomura Kenichiro、Toyama Sumika、Okada Naoko、Ohno Tatsukuni、Tamari Masato、Orimo Keisuke、Mishima Yuko、Suto Hajime、Okumura Ko、Sudo Katsuko、Miyazawa Hiroshi、Taguchi Haruhiko、Saito Hirohisa、Matsumoto Kenji、Nakae Susumu
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 11721-11721

    • DOI

      10.1038/s41598-018-30259-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11500, KAKENHI-PROJECT-18K08395, KAKENHI-PROJECT-18K16167, KAKENHI-PROJECT-17H07096
  • [Journal Article] Mast cells can suppress papain-induced natural helper-cell-mediated innate-type allergic inflammation2015

    • Author(s)
      Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis C, Gali SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
    • Journal Title

      Immunity

      Volume: In press

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25860822
  • [Journal Article] Silica and Double-Stranded RNA Synergistically Induce Bronchial Epithelial Apoptosis and Airway Inflammation2014

    • Author(s)
      Unno H, Futamura K, Morita H, Kojima R, Arae K, Nakae S, Ida H, Saito H, Matsumoto K, Matsuda A
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: (in press) Issue: 3 Pages: 344-353

    • DOI

      10.1165/rcmb.2013-0281oc

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390262, KAKENHI-PROJECT-23591666, KAKENHI-PROJECT-25860822, KAKENHI-PROJECT-26461491
  • [Journal Article] Gastrointestinal Food Allergy in Infants2013

    • Author(s)
      Morita, H., I. Nomura, A. Matsuda, H. Saito, and K. Matsumoto
    • Journal Title

      Allergol. Int.

      Volume: 62 Issue: 3 Pages: 297-307

    • DOI

      10.2332/allergolint.13-RA-0542

    • NAID

      130004477199

    • ISSN
      1323-8930, 1440-1592
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591666, KAKENHI-PROJECT-25860822
  • [Journal Article] Role of Interleukin-33 in Innate-Type Immune Cells in Allergy2013

    • Author(s)
      Nakae S, Morita H, Ohno T, Arae K, Matsumoto K, Saito H
    • Journal Title

      Allergol. Int.

      Volume: 62 Issue: 1 Pages: 13-20

    • DOI

      10.2332/allergolint.13-RAI-0538

    • NAID

      130004477181

    • ISSN
      1323-8930, 1440-1592
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390262, KAKENHI-PROJECT-24659520, KAKENHI-PROJECT-24791005, KAKENHI-PROJECT-25860822
  • [Presentation] Cell fusions of primary human trophoblast depend on BMP4, but maturation like hormonal secretion requires further triggers2023

    • Author(s)
      Hiromi Tanabe, Kenichiro Motomura, Keisuke Orimo, Hiroki Sugiyama, Motohiro Kuriyama, Hideaki Morita, Kenji Miyado, Kenji Matsumoto
    • Organizer
      日本分子生物学会第45回大会
    • Data Source
      KAKENHI-PROJECT-22K09608
  • [Presentation] Environmental factors potentially disrupting the gut epithelial barriers2023

    • Author(s)
      Hideaki Morita
    • Organizer
      EAACI Summer Symposium on Epithelial Cell Biology 2023
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27638
  • [Presentation] Food Protein-Induced Enterocolitis Syndrome (FPIES) in Japan2023

    • Author(s)
      Hideaki Morita
    • Organizer
      World Allergy Organization Symposium Food and Respiratory Allergies
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27638
  • [Presentation] Characteristics of Food Protein-Induced Enterocolitis Syndrome (FPIES) in Japan2023

    • Author(s)
      Hideaki Morita
    • Organizer
      World Allergy Congress 2023
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27638
  • [Presentation] Environmental factors potentially disrupting the gut epithelial barriers2023

    • Author(s)
      Hideaki Morita
    • Organizer
      EAACI Summer Symposium on Epithelial Cell Biology 2023
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19536
  • [Presentation] Environmental factors trigger allergic inflammation through disruption/activation of epithelial cells2022

    • Author(s)
      Hideaki Morita, Kenji Matsumoto
    • Organizer
      The 51st Annual Meeting of The Japanese Society of Immunology
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19536
  • [Presentation] Role of innate immunity in allergic diseases2022

    • Author(s)
      Hideaki Morita
    • Organizer
      Asia Pacific Academy of Pediatric Allergy, Respirology&Immunology 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H01622
  • [Presentation] Environmental factors trigger allergic inflammation through disruption/activation of epithelial cells2022

    • Author(s)
      Hideaki Morita, Kenji Matsumoto
    • Organizer
      The 51st Annual Meeting of The Japanese Society of Immunology
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H01622
  • [Presentation] Role of innate immunity in allergic diseases2022

    • Author(s)
      Hideaki Morita
    • Organizer
      Asia Pacific Academy of Pediatric Allergy, Respirology&Immunology 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19536
  • [Presentation] Inhaled laundry detergents induce eosinophilic airway inflammation through IL-33 and ILC2 activation2022

    • Author(s)
      Hideaki Morita
    • Organizer
      EAACI Summer Symposium on Epithelial Barriers and Microbiome
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H01622
  • [Presentation] 合胞体栄養細胞(STB)の形成において、BMP4は細胞融合を誘導するが、ホルモン分泌など成熟したSTBの形成には他の因子を必要とする2022

    • Author(s)
      田邉裕美、本村健一郎、折茂圭介、杉山弘樹、栗山幹浩、森田英明、宮戸健二、松本健治
    • Organizer
      日本分子生物学会第45回大会
    • Data Source
      KAKENHI-PROJECT-22K09608
  • [Presentation] 乳児期の免疫機構とアレルギー疾患発症予防戦略2021

    • Author(s)
      森田英明、斎藤博久、松本健治
    • Organizer
      第70回日本アレルギー学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H01622
  • [Presentation] Role of innate immunity in the development of allergic diseases2019

    • Author(s)
      1)Morita H, Matsumoto K
    • Organizer
      The 48th Annual Meeting of the Japanese Society of Immunology
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K16167
  • [Presentation] Retinoic acid converts human group 2 innate lymphoid cells to a regulatory phenotype2018

    • Author(s)
      Morita H, Kubo T, Nakae S, Saito H, Matsumoto K, Akdis M, Akdis CA
    • Organizer
      The 3rd International Conference on Innate Lymphoid Cells
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16167
  • [Presentation] Retinoic acid controls lung homeostasis by converting group 2 innate lymphoid cells to a regulatory phenotype2018

    • Author(s)
      Morita H
    • Organizer
      32nd Symposium of the Collegium Internationale Allergologium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16167
  • [Presentation] Innate immunity in allergic inflammation.2018

    • Author(s)
      Morita H
    • Organizer
      The 14th Research Symposium on Human Natural Defense System
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16167
  • [Presentation] 好酸球性気道炎症の病態形成におけるILC2の役割2018

    • Author(s)
      森田英明
    • Organizer
      第67回日本アレルギー学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K16167
  • [Presentation] Non-IgE mediated food allergy2013

    • Author(s)
      Hideaki Morita
    • Organizer
      Asia Pacific Congress of Allergy, Asthma and Clinical Immunology 2013
    • Place of Presentation
      Taipei
    • Invited
    • Data Source
      KAKENHI-PROJECT-25860822
  • [Presentation] 抗原が含有するプロテアーゼによる炎症惹起とアレルギー疾患の発症に関するメカニズム2013

    • Author(s)
      森田 英明
    • Organizer
      第25回 日本アレルギー学会 春季臨床大会
    • Place of Presentation
      横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-25860822
  • 1.  Nakae Susumu (60450409)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  大矢 幸弘 (80392512)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  生谷 尚士 (40513718)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  田邉 裕美 (70804277)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  松本 健治 (60181765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  宮戸 健二 (60324844)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  SAITO Hirohisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  杉田 和成
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  岡田 直子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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