YAMAMOTO Naoki 山本直樹

Researcher Number	90393157
Other IDs
Affiliation (Current)	2025: 姫路獨協大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 姫路獨協大学, 薬学部, 教授 2017: 北陸大学, 薬学部, 講師 2013 – 2015: 北陸大学, 薬学部, 講師 2010 – 2012: 立命館大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 55050:Anesthesiology-related / Pharmacology in pharmacy Except Principal Investigator Anesthesiology / Nerve anatomy/Neuropathology
Keywords	Principal Investigator アストロサイト / 薬剤性錐体外路系障害 / オートファジー / エンドサイトーシス / 錐体外路障害 / 吸入麻酔薬 / 2型糖尿病 / 術後認知機能障害 / 炎症 / 術後認知機能 … More / 麻酔薬 / 糖尿病 / GM1 ガングリオシド / ネプリライシン / アミロイドβ蛋白 / GM1ガングリオシド / 神経細胞 / アルツハイマー病 … More Except Principal Investigator 認知症 / アストロサイト / 神経細胞 / 麻酔薬 / 高次脳機能 / アルツハイマー / 麻酔 / アルツハイマー型認知症 / NMR / 質量分析 / 老人斑 / アミロイドベータ蛋白質 / アルツハイマー病 / 糖鎖 / 痴呆 / 蛋白質 / 神経変性疾患 Less

Elucidation of drug-induced extrapyramidal symptoms caused by abnormalities in endocytosis of astrocytesPrincipal Investigator
- Principal Investigator
  
  Yamamoto Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Himeji Dokkyo University
Elucidation of the effects of impaired glucose tolerance in the brain on postoperative cognitive dysfunction and establishment of its preventive methodsPrincipal Investigator
- Principal Investigator
  
  Yamamoto Naoki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Himeji Dokkyo University
Establishment of safe anesthesia methods for dementia patients
- Principal Investigator
  
  SOBUE Kazuya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Nagoya City University
Investigation of inhibitory materials for Abeta amyloidgenesis including inhibitory function of GM1 ganglioside expressionPrincipal Investigator
- Principal Investigator
  
  Yamamoto Naoki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Hokuriku University
Study on molecular mechanism underlying brain region-specific Ass deposition
- Principal Investigator
  
  YANAGISAWA Katsuhiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Center for Geriatrics and Gerontology

All 2022 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Poly(I:C) promotes neurotoxic amyloid β accumulation through reduced degradation by decreasing neprilysin protein levels in astrocytes.2022
- Author(s)
  Yamamoto N, Tokumon T, Obuchi A, Kono M, Saigo K, Tanida M, Ikeda-Matsuo Y, Sobue K.
- Journal Title
  
  J Neurochem.
  
  Volume: 163 Issue: 6 Pages: 517-530
- DOI
  10.1111/jnc.15716
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06610, KAKENHI-PROJECT-20H04133
[Journal Article] Protein kinases A and C regulate amyloid-β degradation by modulating protein levels of neprilysin and insulin-degrading enzyme in astrocytes2020
- Author(s)
  Yamamoto N, Nakazawa M, Nunono N, Yoshida N, Obuchi A, Tanida M, Suzuki K, Ikeda-Matsuo Y, Sobue K.
- Journal Title
  
  Neurosci Res
  
  Volume: 166 Pages: 62-72
- DOI
  10.1016/j.neures.2020.05.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07129, KAKENHI-PROJECT-18K08833, KAKENHI-PROJECT-21K06610
[Journal Article] Central Injection of Leptin Increases Sympathetic Nerve Outflows to the Stomach and Spleen in Anesthetized Rats.2019
- Author(s)
  Tanida M, Iwasaki Y, Yamamoto N.
- Journal Title
  
  In Vivo
  
  Volume: 33 Issue: 6 Pages: 1827-1832
- DOI
  10.21873/invivo.11675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08833
[Journal Article] Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes.2018
- Author(s)
  Yamamoto N, Ishikuro R, Tanida M, Suzuki K, Ikeda-Matsuo Y, Sobue K.
- Journal Title
  
  Neuroscience
  
  Volume: 385 Pages: 227-236
- DOI
  10.1016/j.neuroscience.2018.06.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08833
[Journal Article] The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes.2017
- Author(s)
  Kasahara, R., Yamamoto, N., Suzuki, K. and Sobue, K.
- Journal Title
  
  Neuroscience
  
  Volume: 340 Pages: 176-187
- DOI
  10.1016/j.neuroscience.2016.10.058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08050, KAKENHI-PROJECT-15K10541
[Journal Article] Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways.2017
- Author(s)
  Yamamoto N, Shibata M, Ishikuro R, Tanida M, Taniguchi Y, Ikeda-Matsuo Y, Sobue K.
- Journal Title
  
  Neuroscience.
  
  Volume: 362 Pages: 70-78
- DOI
  10.1016/j.neuroscience.2017.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09767, KAKENHI-PROJECT-15K10541
[Journal Article] Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways.2016
- Author(s)
  Yamamoto, N., Fujii, Y., Kasahara, R., Tania, M., Ohora, K., Ono, Y., Suzuki, K. and Sobue, K.
- Journal Title
  
  Glia
  
  Volume: 64 Issue: 6 Pages: 952-962
- DOI
  10.1002/glia.22974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08050, KAKENHI-PROJECT-15K10541, KAKENHI-PROJECT-25870906, KAKENHI-PROJECT-26870672, KAKENHI-PROJECT-16K09767
[Journal Article] Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase.2015
- Author(s)
  Tanida M, Yamamoto N, Morgan DA, Kurata Y, Shibamoto T, Rahmouni K.
- Journal Title
  
  J Neurosci.
  
  Volume: 35 Issue: 2 Pages: 4747-484
- DOI
  10.1523/jneurosci.1828-14.2015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25870906, KAKENHI-PROJECT-26870672
[Journal Article] dazolam inhibits the formation of amyloid fibrils and GM1 ganglioside-rich microdomains in presynaptic membranes through the gamma-aminobutyric acid A receptor.2015
- Author(s)
  Yamamoto N, Arima H, Sugiura T, Hirate H, Kusama N, Suzuki K, Sobue K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 457 Issue: 4 Pages: 547-53
- DOI
  10.1016/j.bbrc.2015.01.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592311, KAKENHI-PROJECT-25870906, KAKENHI-PROJECT-26462343, KAKENHI-PROJECT-15K08050, KAKENHI-PROJECT-15K10541
[Journal Article] Hypothalamic Nesfatin-1 Stimulates Sympathetic Nerve Activity via Hypothalamic ERK Signaling.2015
- Author(s)
  Tanida, M., Gotoh, H., Yamamoto, N., Wang, M., Kuda, Y., Kurata, Y., Mori, M., Shibamoto, T.
- Journal Title
  
  Diabetes
  
  Volume: 64 Issue: 11 Pages: 3725-3736
- DOI
  10.2337/db15-0282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870906, KAKENHI-PROJECT-26870672
[Journal Article] Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes.2014
- Author(s)
  Yamamoto N,Tanida M,Ono Y,Kasahara R,Fujii Y,Ohora K,Suzuki K,Sobue K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 445 Issue: 1 Pages: 214-7
- DOI
  10.1016/j.bbrc.2014.01.168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592311, KAKENHI-PROJECT-25870906, KAKENHI-PROJECT-26870672
[Journal Article] Leptin inhibits amyloid β-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway.2014
- Author(s)
  Yamamoto N, Tanida M, Kasahara R, Sobue K, Suzuki K
- Journal Title
  
  J Neurochem
  
  Volume: 131 Issue: 3 Pages: 323-32
- DOI
  10.1111/jnc.12828
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592311, KAKENHI-PROJECT-25870906, KAKENHI-PROJECT-26870672
[Journal Article] Propofol and thiopental suppress amyloid fibril formation and GM1 ganglioside expression through the γ-aminobutyric acid A receptor.2013
- Author(s)
  Yamamoto N,Arima H,Sugiura T,Hirate H,Taniura H,Suzuki K,Sobue K
- Journal Title
  
  Anesthesiology
  
  Volume: 118 Issue: 6 Pages: 1408-16
- DOI
  10.1097/aln.0b013e31828afc16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592311, KAKENHI-PROJECT-25870906
[Journal Article] Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner.2013
- Author(s)
  谷田守
- Journal Title
  
  Neuroscience
  
  Volume: 238 Pages: 297-304
- DOI
  10.1016/j.neuroscience.2013.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-25460100, KAKENHI-PROJECT-25870906
[Journal Article] Propofol and thiopental suppress amyloid fibril formation and GM1 ganglioside expression through the gamma-aminobutyric acid A receptor.2013
- Author(s)
  山本直樹
- Journal Title
  
  Anesthesiology (In press)
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Density of GM1 in Nanoclusters Is a Critical Factor in the Formation of a Spherical Assembly of Amyloid β-Protein on Synaptic Plasma Membranes.2013
- Author(s)
  Teruhiko Matsubara, Kazutoshi Iijima, Naoki Yamamoto, Katsuhiko Yanagisawa, and Toshinori Sato
- Journal Title
  
  Langmuir
  
  Volume: 29(7) Issue: 7 Pages: 2258-2264
- DOI
  10.1021/la3038999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-23241075
[Journal Article] Ketamine reduces amyloid β-protein degradation by suppressing neprilysin expression in primary cultured astrocytes.2013
- Author(s)
  Yamamoto N,Arima H,Naruse K,Kasahara R,Taniura H,Hirate H,Sugiura T,Suzuki K,Sobue K
- Journal Title
  
  Neurosci Lett
  
  Volume: 545 Pages: 54-8
- DOI
  10.1016/j.neulet.2013.04.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592311, KAKENHI-PROJECT-25870906
[Journal Article] Brain insulin resistance accelerates Ass fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes2012
- Author(s)
  Yamamoto N, Matsubara T, Sobue K., et al
- Journal Title
  
  J.Neurochem.
  
  Volume: 121 Issue: 4 Pages: 619-628
- DOI
  10.1111/j.1471-4159.2012.07668.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118, KAKENHI-PROJECT-24592311
[Journal Article] Central AMP-activated protein kinase affects sympathetic nerve activity in rats2011
- Author(s)
  Tanida M, Yamamoto N
- Journal Title
  
  Neurosci Lett.
  
  Volume: 503 Issue: 3 Pages: 167-170
- DOI
  10.1016/j.neulet.2011.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Surface-induced phase separation of a sphingomyelin/cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Ass oligomerization.2010
- Author(s)
  Mao Y, (Yamamoto N, Yanagisawa K), et al.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1798 Pages: 1090-1099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Journal Article] Extracellular and intraneuronal HMW-Abeta Os represent a molecular basis of memory loss in Alzheimer's disease model mouse.
- Author(s)
  Takamura Y, (Yamamoto N, Yanagisawa K), et al.
- Journal Title
  
  Mol Neurodegener
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] アストロサイト発現ネプリライシンはpoly I:Cによる発現低下によってアミロイドβ蛋白の分解を抑制する2020
- Author(s)
  山本直樹、徳門巧也、大渕絢子、谷田守、松尾由理、祖父江和哉
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K08833
[Presentation] アストロサイト発現ネプリライシンはpoly I:Cによって発現低下がもたらされる2019
- Author(s)
  山本直樹、徳門巧也、大渕絢子、谷田守、松尾由理、祖父江和哉
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08833
[Presentation] Insulin regulates expression of neprilysin and IDE in cultured astrocytes2018
- Author(s)
  Yamamoto N, Ishikuro R, Tanida M, Suzuki K, Sobue K.
- Organizer
  第61回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18K08833
[Presentation] インスリンによるアストロサイトのネプリライシンとインスリン分解酵素の発現調節の検討2018
- Author(s)
  山本直樹、谷田守、石黒凌、祖父江和哉
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15K10541
[Presentation] PKAおよびPKC経路とアストロサイトのネプリライシンとインスリン分解酵素発現検討2018
- Author(s)
  山本直樹、祖父江和哉
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08833
[Presentation] 培養アストロサイト発現ネプリライシンとインスリン分解酵素のインスリンによる発現調節の検討2017
- Author(s)
  山本直樹、谷田守、石黒凌、祖父江和哉
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-15K10541
[Presentation] 脂溶性スタチンはアストロサイト細胞膜表面のネプリライシン発現を低下させる2016
- Author(s)
  山本直樹、谷田守、有馬一、鈴木健二、祖父江和哉
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] 没食子酸エピガロカテキンはアストロサイトのネプリライシン発現を低下させる2016
- Author(s)
  柴田麻里、山本直樹、石黒凌、谷田守、有馬一、祖父江和哉
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] インスリンはアストロサイトのネプリライシンとインスリン分解酵素の発現を調節する2016
- Author(s)
  石黒凌、山本直樹、柴田麻里、谷田守、有馬一、祖父江和哉
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] スタチンとアストロサイトのネプリライシン発現調節の検討2015
- Author(s)
  山本直樹、谷田守、有馬一、鈴木健二、祖父江和哉
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] レプチンはアストロサイトのネプリライシン発現を抑制する2015
- Author(s)
  山本直樹、谷田守、大野陽子、笠原梨加、鈴木健二、祖父江和哉
- Organizer
  第58回日本神経化学会
- Place of Presentation
  大宮
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] ミダゾラムによるAβ重合体形成の抑制検討2015
- Author(s)
  山本直樹、有馬一、祖父江和哉
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] ミダゾラムはAß重合体形成を抑制する2014
- Author(s)
  山本直樹、有馬一、祖父江和哉
- Organizer
  第33回日本認知症学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-29
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] レプチンはアストロサイトのネプリライシン発現を抑制することでAß分解を抑制する2014
- Author(s)
  山本直樹、谷田守、大野陽子、笠原梨加、鈴木健二、祖父江和哉
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] Midazolam inhibit the formation of Aß assemblies from neuronal membrane2014
- Author(s)
  山本直樹、有馬一、祖父江和哉
- Organizer
  第57回日本神経化学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-09-29
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] レプチンは神経細胞表面のGM1ガングリオシド減少によってAß重合体形成を抑制する2014
- Author(s)
  山本直樹、谷田守、祖父江和哉、鈴木健二
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] レプチンは神経細胞膜のGM1ガングリオシド発現減少を介してAß重合体形成を抑制する2013
- Author(s)
  山本直樹、谷田守、祖父江和哉、谷浦秀夫、鈴木健二
- Organizer
  第55回日本神経化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] 脳内インスリン抵抗性はシナプス膜表面のGM1集積化を介したAβ重合体形成を誘導する2013
- Author(s)
  山本直樹
- Organizer
  第133回日本薬学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] ミダゾラムは神経細胞膜からのAß重合を抑制する2013
- Author(s)
  山本直樹、有馬一、祖父江和哉
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] レプチンは神経細胞膜表面からのAß重合体形成を抑制する2013
- Author(s)
  山本直樹、谷田守、祖父江和哉、谷浦秀夫、鈴木健二
- Organizer
  第32回日本認知症学会学術集会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-25870906
[Presentation] Aging and peripheral insulin resistance induce brain insulin resistance and amyloid β-protein fibrillogenesis2012
- Author(s)
  山本直樹
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] アミロイドベータの凝集機構の解明のためのGM1含有生体膜モデルの構築2012
- Author(s)
  福田竜統, 小島昂大, 松原輝彦, 山本直樹, 柳澤勝彦, 佐藤智典
- Organizer
  日本化学会第92春季年会(2012)
- Place of Presentation
  慶應義塾大学(横浜)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] Brain insulin resistance induces Aβ fibrillogenesis through GM1 ganglioside clustering on the surface of presynaptic membranes2012
- Author(s)
  山本直樹
- Organizer
  第55回日本神経化学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] ケタミン処理したアストロサイトはネプリライシン発現抑制を介してアミロイドβ蛋白分解を抑制する2012
- Author(s)
  山本直樹、成瀬かおり、笠原梨加、谷浦秀夫、鈴木健二、祖父江和哉
- Organizer
  第132回日本薬学会
- Place of Presentation
  北海道(札幌)
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] プロポフォールとチオペンタールはアミロイドβ凝集を抑制する-アルツハイマー型認知症患者への麻酔薬使用は問題ないのか?第2報-2011
- Author(s)
  祖父江和哉、山本直樹、谷浦秀夫、高柳猛彦、伊藤恭史、森島徹朗
- Organizer
  日本麻酔科学会第58回学術集会
- Place of Presentation
  兵庫県(神戸)
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] GM1含有脂質膜におけるアミロイドベータの凝集機構の解析2011
- Author(s)
  小島昂大, 松原輝彦, 山本直樹, 柳澤勝彦, その他
- Organizer
  日本化学会第91春季年会
- Place of Presentation
  神奈川大学(神奈川県)
- Year and Date
  2011-03-15
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] ハロペリドールはシグマ-1受容体を介してアストロサイトのGM1発現を増加させる2011
- Author(s)
  笠原梨加、山本直樹、成瀬かおり、谷浦秀夫、鈴木健二、祖父江和哉
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  神奈川県(横浜)
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] ケタミンはアストロサイトのネプリライシン発現を抑制することでAssの分解を減少させる2011
- Author(s)
  山本直樹、成瀬かおり、笠原梨加、谷浦秀夫、鈴木健二、祖父江和哉
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  神奈川県(横浜)
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] NMR analyses of carbohydrate-protein interaction systems as potential therapeutic targets2011
- Author(s)
  Koichi Kato, Hirokazu Yagi, Takumi Yamaguchi, Sayoko Yamamoto, Yukiko Kamiya, Maho Yagi-Utsumi
- Organizer
  Glycobiology Japan-Netherland Joint Seminar 2011
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2011-10-10
- Data Source
  KAKENHI-PROJECT-22300118
[Presentation] ケタミンはアストロサイトのネプリライシン発現抑制を介してAssの分解を抑制する2011
- Author(s)
  山本直樹、成瀬かおり、笠原梨加、谷浦秀夫、鈴木健二、祖父江和哉
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22300118

1. SOBUE Kazuya (90264738)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. YANAGISAWA Katsuhiko (10230260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. KATO Koichi (20211849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. MURAYAMA Shigeo (50183653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MATSUBARA Teruhiko (10325251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. ISHII Fumiyasu (90515610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 杉浦健之 (20295611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 浅井清文 (70212462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUZUKI Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 谷田守

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 池田由理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAMOTO Naoki 山本 直樹

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Elucidation of drug-induced extrapyramidal symptoms caused by abnormalities in endocytosis of astrocytesPrincipal Investigator

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Elucidation of the effects of impaired glucose tolerance in the brain on postoperative cognitive dysfunction and establishment of its preventive methodsPrincipal Investigator

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Establishment of safe anesthesia methods for dementia patients

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Investigation of inhibitory materials for Abeta amyloidgenesis including inhibitory function of GM1 ganglioside expressionPrincipal Investigator

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Study on molecular mechanism underlying brain region-specific Ass deposition

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[Journal Article] Poly(I:C) promotes neurotoxic amyloid β accumulation through reduced degradation by decreasing neprilysin protein levels in astrocytes.2022

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[Journal Article] Protein kinases A and C regulate amyloid-β degradation by modulating protein levels of neprilysin and insulin-degrading enzyme in astrocytes2020

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[Journal Article] Central Injection of Leptin Increases Sympathetic Nerve Outflows to the Stomach and Spleen in Anesthetized Rats.2019

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[Journal Article] Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes.2018

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[Journal Article] The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes.2017

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[Journal Article] Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways.2017

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[Journal Article] Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways.2016

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[Journal Article] Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase.2015

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[Journal Article] dazolam inhibits the formation of amyloid fibrils and GM1 ganglioside-rich microdomains in presynaptic membranes through the gamma-aminobutyric acid A receptor.2015

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[Journal Article] Hypothalamic Nesfatin-1 Stimulates Sympathetic Nerve Activity via Hypothalamic ERK Signaling.2015

YAMAMOTO Naoki 山本直樹