FUJIKAWA Keita 藤川敬太

… Alternative Names

FUJIKAMA Keita 藤川敬太

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Researcher Number	90404285
External Links
Affiliation (based on the past Project Information) *help	2010: 長崎大学, 病院, 医員 2006 – 2008: 長崎大学, 医学部・歯学部附属病院, 医員
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 Except Principal Investigator 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator CaMKII / HL-60 / PADI / CaMK II / 滑膜線維芽細胞 / 関節リウマチ / 蛋白シトルリン化 Except Principal Investigator HL-60 / PADI4 / CaMKII … More / Akt / 蛋白シトルリン化 / 滑膜線維芽細胞(FLS) / 滑膜線維芽細胞 / シトルリン化 / 関節リウマチ / citrullination / apoptosis / RA / FLS / 治療ターゲット / TRAIL依存性アポトーシス / CIA / 細胞分化 / 関節リウマチ(RA) / アポトーシス / 関節リウマチ(Ra) / ヒストン / 末梢血単核球(PBMC) / Treg / PADI2 / 骨髄浮腫 / 抗CCP抗体 / CaMK II / PADIs / 免疫担当細胞 / 滑膜細胞 Less

Can we explain the varying pathologic processes of rheumatoid arthritis by CaMKII delta abnormality?
- Principal Investigator
  
  KAWAKAMI Atsushi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Nagasaki University
滑膜線維芽細胞の蛋白シトルリン化を誘導する刺激伝達経路の解明Principal Investigator
- Principal Investigator
  
  藤川敬太
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Nagasaki University
Investigation for the possibility of CaMKII activity modulation for the therapeutic optical in rheumatoid arthritis
- Principal Investigator
  
  KAWAKAMI Atsushi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Nagasaki University

All 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics.2010
- Author(s)
  Kawashiri SY, Kawakami A, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Arima K, Ichinose K, Kamachi M, Yamasaki S, Nakamura H, Origuchi T, Ida H, Eguchi K.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 20(1) Pages: 40-45
- NAID
  10027168341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] Decrement of serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis (RA) patients achieving remission after 6 months of etanercept treatment : comparison with CRP, IgM-RF, MMP-3 and anti-CCP Ab.2010
- Author(s)
  Kawashiri S, Kawakami A, Imazato T, Ueki Y, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Arima K, Kamachi M, Nakamura H, Origuchi T, Ida H, Eguchi K.
- Journal Title
  
  Joint Bone Spine
  
  Volume: 77(5) Pages: 418-420
- NAID
  120006984935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] インフリキシマブの関節リウマチ患者の炎症所見、活動性とADLに対する効果2010
- Author(s)
  折口智樹, 川尻真也, 岩本直樹, 玉井慎美, 井田弘明, 川上純, 藤川敬太, 荒牧俊幸, 松岡直樹, 植木幸孝, 河部庸次郎, 峰雅宣, 福田孝昭, 江口勝美
- Journal Title
  
  日本RAのリハビリ研究会誌
  
  Volume: 24 Pages: 62-64
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] Decrement of serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis (RA) patients achieving remission after 6 months of etanercept treatment : comparison with CRP, IgM-RF, MMP-3 and anti-CCP Ab.2010
- Author(s)
  Kawashiri S, Kawakami A, Imazato T, Ueki Y, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Arima K, Kamachi M, Nakamura H, Origuchi T, Ida H, Eguchi K
- Journal Title
  
  Joint Bone Spine 77(5)
  
  Pages: 418-420
- NAID
  120006984935
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics.2010
- Author(s)
  Kawashiri SY, Kawakami A, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Arima K, Ichinose K, Kamachi M, Yamasaki S, Nakamura H, Origuchi T, Ida H, Eguchi K
- Journal Title
  
  Mod Rheumatol 20(1):
  
  Pages: 40-45
- NAID
  10027168341
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] Calcium/calmodulin-dependent protein kinase II(CaMKII)regulates tomour necrosis factor-related apoptosis inducing ligand(TRAIL)-mediated apoptosis of fibroblast-like synovial cells(FLS)by phosphorylation of Akt.2009
- Author(s)
  Fujikawa K, Kawakami, et al.(2番目, 他4名)
- Journal Title
  
  Clin ExpRheumatol 27
  
  Pages: 952-957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion.2009
- Author(s)
  Fujikawa K, Kawakami A, Tamai M, Uetani M, Takao S, Arima K, Iwamoto N, Aramaki T, Kawashiri S, Ichinose K, Kamachi M, Nakamura H, Origuchi T, Ida H, Aoyagi K, Eguchi K
- Journal Title
  
  J Rheumatol 36(6)
  
  Pages: 1126-1129
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies.2009
- Author(s)
  Tamai M, Kawakami A, Uetani M, Takao S, Arima K, Iwamoto N, Fujikawa K, Aramaki T, Kawashiri S, Ichinose K, Kamachi M, Nakamura H, Origuchi T, Ida H, Aoyagi K, Eguchi K
- Journal Title
  
  Arthritis Rheum 61(6)
  
  Pages: 772-778
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like synovial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modifying antirheumatic drugs.2009
- Author(s)
  Kawashiri S, Kawakami A, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Arima K, Kamachi M, Yamasaki S, Nakamura H, Tsurumoto T, Kono M, Shindo H, Ida H, Origuchi T, Eguchi K
- Journal Title
  
  J Rheumato 136(11)
  
  Pages: 2397-2402
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt.2009
- Author(s)
  Fujikawa K, Kawakami A, Tanaka F, Iwamoto N, Tamai M, Eguchi K
- Journal Title
  
  Clin Exp Rheumato 127(6)
  
  Pages: 952-957
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] High serum cartilage oligometric matrix protein determines the subset of early-stage RA patients with high serum C-reactive protein, matrix metalloproteinase 3 and MRI-proven bone erosion.2009
- Author(s)
  Fujikawa K, Kawakami, et al. (2番目, 他14名)
- Journal Title
  
  J Rheumatol accepted(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] 【関節リウマチ治癒を目指す治療の新時代へ】治療に直結する病因・病態研究最前線治療反応性と関連する予後因子2009
- Author(s)
  川上純, 玉井慎美, 岩本直樹, 川尻真也, 藤川敬太, 江口勝美
- Journal Title
  
  最新医学 64(5)
  
  Pages: 974-980
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis.2009
- Author(s)
  Aramaki T, Ida H, Izumi Y, Fujikawa K, Huang M, Arima K, Tamai M, Kamachi M, Nakamura H, Kawakami A, Origuchi T, Matsuoka N, Eguchi K
- Journal Title
  
  Mod Rheumatol 19(3)
  
  Pages: 245-252
- NAID
  10025112851
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] Different expression levels of TNF receptors on the rheumatoid synovial macrophages derived from surgery and a synovectomy as detected by a new flow cytometric analysis.2009
- Author(s)
  Ida H, Aramaki T, Nakamura H, Fujikawa K, Arima K, Tamai M, Kamachi M, Satoh K, Origuchi T, Kawakami A, Furuichi I, Kawabe Y, Eguchi K
- Journal Title
  
  Cytotechnology 60(1-3)
  
  Pages: 161-164
- Data Source
  KAKENHI-PROJECT-20591173
[Journal Article] Induction by infliximab of significant recovery from multiple cranial nerve palsy of Wegener's granulomatosis2008
- Author(s)
  藤川敬太, 他
- Journal Title
  
  The Journal of Rheumatology 35(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659294
[Journal Article] Successful treatment of refractory neuro-Behcet's disease with infliximab:a case report to show its efficacy by magnetic resonance imaging,transcranial magnetic stimulation and cytolcine profile2007
- Author(s)
  Fujikawa K, Kawakami A, Eguchi K(3番目, 他12名)
- Journal Title
  
  Annals of the rheumatic diseases 66(1)
  
  Pages: 136-137
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591116
[Journal Article] Successful treatment of refractory neuro-Behcet's disease with infliximab : a case report to show its efficacy by magnetic resonance imaging, transcranial magnetic stimulation and cytokine profile2007
- Author(s)
  Fujikawa, K., Aratake, K., Kawakami, A., et. al.
- Journal Title
  
  Annals of the rheumatic diseases 66(1)
  
  Pages: 136-137
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591116
[Journal Article] 可溶性TNF受容体IgGキメラ(エタネルセプト)2007
- Author(s)
  藤川敬太, 川上純, 江口勝美
- Journal Title
  
  日本臨床 65(7)
  
  Pages: 1211-1217
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591116
[Journal Article] Successful treatment of refractory neuro-Behcet's disease with infliximab : a case report to show its efficacy by magnetic resonance imaging, transcranial magnetic stimulation and cytokine profile.2007
- Author(s)
  藤川敬太他
- Journal Title
  
  Annals of Rheumatic Disease 66(1)
  
  Pages: 136-137
- Data Source
  KAKENHI-PROJECT-18659294
[Presentation] 自己抗体と手指関節非造影MRIを用いるNagasaki scoreの評価2010
- Author(s)
  玉井慎美, 川上純, 上谷雅彦, 有馬和彦, 岩本直樹, 藤川敬太, 中村英樹, 井田弘明, 折口智樹, 青柳潔, 江口勝美
- Organizer
  第54回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] 診断未確定関節炎コホートを用いたACR 2009新基準の評価2010
- Author(s)
  玉井慎美, 川上純, 岩本直樹, 藤川敬太, 有馬和彦, 中村英樹, 折口智樹, 井田弘明, 青柳潔, 上谷雅彦, 江口勝美
- Organizer
  第54回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] 関節リウマチの早期診断:ACR 2009新基準、Nagasaki score、Leiden scoreの比較2010
- Author(s)
  玉井慎美, 川上純, 喜多潤子, 岩本直樹, 川尻真也, 有馬和彦, 藤川敬太, 上谷雅孝, 青柳潔, 江口勝美
- Organizer
  第107回日本内科学会総会・講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] A prediction rule for disease outcome in patients with undifferentiated arthritis using mri of wrists and finger joints and serologic autoantibodies.2009
- Author(s)
  Tamai M, Kawakami A, Uetani M, Takao S, Arima K, Iwamoto N, Fujikawa K, Aramaki T, Kawashiri S, Ichinose K, Kamachi M, Nakamura H, Origuchi T, Ida H, Aoyagi K, Eguchi K
- Organizer
  Annual European Congress of Rheumatology EULAR 2009.
- Place of Presentation
  Copenhagen, Dennmark.
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] 関節リウマチを早期に予測するには?2009
- Author(s)
  川上純, 玉井慎美, 岩本直樹, 川尻真也, 藤川敬太, 荒牧俊幸, 一瀬邦弘, 有馬和彦, 蒲池誠, 中村英樹, 井田弘明, 折口智樹, 上谷雅孝, 青柳潔, 江口勝美
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] 関節リウマチにおける末梢血CD4+CD25+CDI27lo/-制御性T細胞の検討2009
- Author(s)
  川尻真也, 川上純, 岩本直樹, 藤川敬太, 荒牧俊幸, 江口勝美
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] A Prediction Rule far Disease Outcome in Patients with Undifferentiated Arthritis by MRI of the Wrists and Finger Joints and Serologic2009
- Author(s)
  玉井慎美, 川上純, 上谷雅孝, 有馬和彦, 藤川敬太, 岩本直樹, 川尻真也, 喜多潤子, 岡田覚丈,古賀智裕, 荒牧俊幸, 蒲池誠, 山崎聡士, 中村英樹, 井田弘明, 折口智樹, 青柳潔, 江口勝美
- Organizer
  Autoantibodies : Second Report Regarding to the Utility of Plain MRL ACR/ARHP Scientific Meeting 2009.
- Place of Presentation
  Philadelphia.
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] MRI骨変化と自己抗体が陽性のUAに対するDMARDs治療の評価2009
- Author(s)
  川上純, 玉井慎美, 岩本直樹, 川尻真也, 藤川敬太, 荒牧俊幸, 一瀬邦弘, 蒲池誠, 中村英樹, 井田弘明, 折口智樹, 有馬和彦, 山崎聡士, 上谷雅孝, 青柳潔, 江口勝美
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] 関節リウマチ(RA)に対する生物学的製剤による悪性腫瘍発生リスクの検討;ナチュラルキラー(NK)細胞への影響(第三報)2008
- Author(s)
  荒牧俊幸, 井田弘明, 川尻真也, 岩本直樹, 藤川敬太, 一瀬邦弘, 玉井慎美, 蒲池誠, 中村英樹, 川上純, 折口智樹, 松岡直樹, 江口勝美
- Organizer
  第52回日本リウマチ学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] 抗CCP抗体と関節リウマチの診断・病態2008
- Author(s)
  川上純, 玉井慎美, 藤川敬太, 岩本直樹, 川尻真也, 江口勝美
- Organizer
  第52回日本リウマチ学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] 関節リウマチにおけるケモカインCCL20と生物学的製剤2008
- Author(s)
  川尻真也, 川上純, 岩本直樹, 藤川敬太, 荒牧俊幸, 一瀬邦弘, 蒲池誠, 玉井慎美, 中村英樹, 井田弘明, 折口智樹, 江口勝美
- Organizer
  第52回本リウマチ学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20591173
[Presentation] 早期関節リウマチにおける血清COMP値と手MRIでの早期骨破壊との関連性2007
- Author(s)
  藤川敬太
- Organizer
  日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591116
[Presentation] 早期関節リウマチにおける血清COMP値と手MRIでの早期骨破壊との関連性2007
- Author(s)
  藤川敬太, 他
- Organizer
  第51回日本リウマチ学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-04-26
- Data Source
  KAKENHI-PROJECT-18659294
[Presentation] 難治性ウェゲナー肉芽腫症に対するInfliximab治療2007
- Author(s)
  藤川敬太
- Organizer
  日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591116
[Presentation] 難治性後天性血友病の一例2007
- Author(s)
  藤川敬太, 他
- Organizer
  第35回日本臨床免疫学会総会
- Place of Presentation
  ホテル阪急エキスポパーク
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-18659294
[Presentation] 難治性ウェゲナー肉芽腫症に対するlnfliximab治療2007
- Author(s)
  藤川敬太, 他
- Organizer
  第51回日本リウマチ学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-04-26
- Data Source
  KAKENHI-PROJECT-18659294
[Presentation] CaMKII阻害による滑膜線維芽細胞アポトーシス感受性の増強2006
- Author(s)
  藤川敬太
- Organizer
  第50回(中)日本リウマチ学会総会・学術集会
- Place of Presentation
  長崎
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591116

1. KAWAKAMI Atsushi (90325639)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
2. TAMAI Mami (60380862)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. ORIGUCHI Tomoki (90295105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. IDA Hiroaki (60363496)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
5. ABIRU Norio (00380981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAWASHIRI Shinya (20457576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results

FUJIKAWA Keita 藤川 敬太

FUJIKAMA Keita 藤川 敬太

Research Projects

Research Products

Co-Researchers

Can we explain the varying pathologic processes of rheumatoid arthritis by CaMKII delta abnormality?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

滑膜線維芽細胞の蛋白シトルリン化を誘導する刺激伝達経路の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation for the possibility of CaMKII activity modulation for the therapeutic optical in rheumatoid arthritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Decrement of serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis (RA) patients achieving remission after 6 months of etanercept treatment : comparison with CRP, IgM-RF, MMP-3 and anti-CCP Ab.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] インフリキシマブの関節リウマチ患者の炎症所見、活動性とADLに対する効果2010

Author(s)

Journal Title

Data Source

[Journal Article] Decrement of serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis (RA) patients achieving remission after 6 months of etanercept treatment : comparison with CRP, IgM-RF, MMP-3 and anti-CCP Ab.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Calcium/calmodulin-dependent protein kinase II(CaMKII)regulates tomour necrosis factor-related apoptosis inducing ligand(TRAIL)-mediated apoptosis of fibroblast-like synovial cells(FLS)by phosphorylation of Akt.2009

Author(s)

Journal Title

Data Source

[Journal Article] High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion.2009

Author(s)

Journal Title

Data Source

[Journal Article] A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies.2009

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[Journal Article] Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like synovial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modifying antirheumatic drugs.2009

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[Journal Article] Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt.2009

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[Journal Article] High serum cartilage oligometric matrix protein determines the subset of early-stage RA patients with high serum C-reactive protein, matrix metalloproteinase 3 and MRI-proven bone erosion.2009

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[Journal Article] 【関節リウマチ治癒を目指す治療の新時代へ】治療に直結する病因・病態研究最前線 治療反応性と関連する予後因子2009

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[Journal Article] A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis.2009

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NAID

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FUJIKAWA Keita 藤川敬太

FUJIKAMA Keita 藤川敬太

[Journal Article] 【関節リウマチ治癒を目指す治療の新時代へ】治療に直結する病因・病態研究最前線治療反応性と関連する予後因子2009