Saitoh Yasukazu 齋藤靖和

… Alternative Names

SAITOH Yasukazu 斉藤靖和

齋藤靖和サイトウヤスカズ

斉藤靖和サイトウヤスカズ

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Researcher Number	90405514
Other IDs
Affiliation (Current)	2026: 県立広島大学, 生命環境学部, 教授 2026: 県立広島大学, 生物資源科学部, 教授
Affiliation (based on the past Project Information) *help	2026: 県立広島大学, 生物資源科学部, 教授 2020 – 2024: 県立広島大学, 生物資源科学部, 教授 2016 – 2019: 県立広島大学, 生命環境学部, 教授 2014 – 2016: 県立広島大学, 生命環境学部, 准教授 2011 – 2012: 県立広島大学, 生命環境学部, 准教授 … More 2010: 県立広島大学, 生命環境学部・生命科学科, 助教 2009: 県立広島大学, 生命環境学部, 助教 2007: Prefectural University of Hiroshima, Faculty of Life and Environmental Sciences, Associate Lecturer 2006: 県立広島大学, 生命環境学部生命科学部, 助手 2005: 県立広島大学, 生命環境学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Applied health science / Food science / Applied health science Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator 細胞老化 / SASP / 線維芽細胞 / 活性酸素 / ヒト線維芽細胞 / Senostatics / Senolysis / 細胞老化随伴分泌現象(SASP) / 細胞老化随伴分泌現象 / スチルベノイド … More / 老化 / アスコルビン酸 / 酸化ストレス / ビタミンC / ストレス / Senomorphics/Senostatics / Senotherapy / ストレス曝露 / ストレス老化 / 複製老化 / senomorphic drug / senolytic drug / 老化制御 / 細胞老化随伴分泌現象（SASP） / プテロスチルベン / プテロスチルベン多糖体 / スチルベノイド誘導体 / ストレス抵抗性 / ストレス防御 / 紫外線 / ビタミンC輸送 / デヒドロアスコルビン酸 / レスベラトロール / 細胞内蓄積 / 細胞内輸送 / 加齢 / SVCT / 細胞死 / 加齢・老化 … More Except Principal Investigator 細胞死 / 活性酸素 / Hydrogen-dissolved water / Cell death defense / Hydroperoxide / Reactive oxygen species / dhar Gene / Vitamin C regeneration / 虚血-再灌流障害 / ビタミンC細胞内取込み / 細胞死制御 / 酸化ストレス軽減 / DNA切断 / 低酸素-再酸素化 / グルタチオン / デヒドロアスコルビン酸 / 細胞死防御 / dhar遺伝子 / 水素水 / 細包死防御 / ヒドロペルオキシド / dhar遣伝子 / ビタミンC再生 / NBT還元法 / CDCFH-DA蛍光計測法 / β-カロテン退色法 / 電子スピン共鳴 / フラーレン / バイオテクノロジー / 薬理学 / 化学修飾 Less

Senostatics効果をもつ食品由来成分の探索から迫る老化細胞制御Principal Investigator
- Principal Investigator
  
  齋藤靖和
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Prefectural University of Hiroshima
Control of senescent cells based on the elucidation of the relationship between SASP and stressPrincipal Investigator
- Principal Investigator
  
  齋藤靖和
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Prefectural University of Hiroshima
A study on the ways to alleviate senescence-associated secretory phenotypePrincipal Investigator
- Principal Investigator
  
  Saitoh Yasukazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Prefectural University of Hiroshima
Study on active intervention for protecting senescent cells based on the mechanism of changes in stress resistance accompanying cellular senescencePrincipal Investigator
- Principal Investigator
  
  Saitoh Yasukazu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Prefectural University of Hiroshima
Study on cellular senescence-induced changes in vitamin C transport/accumulation activity and its regulation mechanismPrincipal Investigator
- Principal Investigator
  
  Saitoh Yasukazu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Prefectural University of Hiroshima
Elucidation of the relationships between senescence-associated decreases in ascorbic acid level and senescence-associated changes in cellular functionsPrincipal Investigator
- Principal Investigator
  
  SAITOH Yasukazu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied health science
- Research Institution
  Prefectural University of Hiroshima
フラーレン各種誘導体の化学構造と抗酸化活性との相関性に関する体系的解析
- Principal Investigator
  
  MIWA Nobuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Prefectural University of Hiroshima
Enhancing effects of vitamin C-regeneration gene and vitamin C recycling on prevention of cell death
- Principal Investigator
  
  MIWA Nobuhiko
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Prefectural University of Hiroshima

[Book] 遠藤守信、飯島澄男編「ナノカーボンハンドブック」第2編、第3章、3-2-6節フラーレン誘導体の抗酸化作用と細胞死抑制効果および医療応用2007
- Author(s)
  廖峰, 甘学輝, 肖黎, 松林賢司, Robiul Md. Islam, 斉藤靖和, 三羽信比古
- Publisher
  (株)エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-17590064
[Book] 「抗しわ活性ビタミンC誘導体と分子メカニズム, アンチ・エイジングシリーズ第2巻「皮膚の抗老化最前線」第3部、第1章、第2-2節2006
- Author(s)
  河村卓也、斉藤靖和、加藤詠子、続木敏、三羽信比古
- Total Pages
  30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590064
[Book] 「抗しわ活性ビタミンC誘導体と分子メカニズム」アンチ・エイジングシリーズ第2巻「皮膚の抗老化最前線」ISBN4-86043-104-9 C3047, 第3部・第1章・第2-2節,pp.201-2302006
- Author(s)
  河村卓也, 斉藤靖和, 加藤詠子, 続木敏, 三羽信比古
- Total Pages
  30
- Publisher
  NTS出版
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] High dose of ascorbic acid induces selective cell growth inhibition and cell death in human gastric signet-ring cell carcinoma-derived NUGC-4 cells2025
- Author(s)
  Saitoh Yasukazu、Takeda Kaori、Okawachi Koichi、Tanimura Yusuke
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1869 Issue: 2 Pages: 130738-130738
- DOI
  10.1016/j.bbagen.2024.130738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K10922
[Journal Article] 複製老化細胞とストレス老化細胞は同質なのか？～老化誘導方法の違いによる表現型と遺伝子発現パターンの差異～2025
- Author(s)
  齋藤靖和
- Journal Title
  
  月刊「細胞」2月号特集「百寿時代」
  
  Volume: 57 Pages: 36-38
- Data Source
  KAKENHI-PROJECT-23K10922
[Journal Article] Inhibitory Effect of 2-Aza-8-oxohypoxanthine on Tyrosinase Activity and Melanin Production2024
- Author(s)
  Aoshima Hisae、Mizuno Ruka、Iwatsu Yuho、Onishi Shiori、Hyodo Sayuri、Ibuki Rinta、Kawagishi Hirokazu、Saitoh Yasukazu
- Journal Title
  
  Cosmetics
  
  Volume: 11 Issue: 2 Pages: 43-43
- DOI
  10.3390/cosmetics11020043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H05620, KAKENHI-PROJECT-23K10922
[Journal Article] Hydrogen-Nano-Bubble-Rich Water in Bucket/Bathtub Improves Intractable Skin Roughness2023
- Author(s)
  Saitoh Yasukazu、Takada Yuki、Miwa Nobuhiko
- Journal Title
  
  Hydrogen
  
  Volume: 4 Issue: 3 Pages: 456-473
- DOI
  10.3390/hydrogen4030031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K10922
[Journal Article] 細胞老化に伴う特徴的な変化からみるSenolysis/Senostaticsの可能性2023
- Author(s)
  齋藤靖和
- Journal Title
  
  月刊細胞　特集「セノリティクス」
  
  Volume: 55 Pages: 32-35
- Data Source
  KAKENHI-PROJECT-20K11627
[Journal Article] Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells.2022
- Author(s)
  Saitoh Y, Yonekura N, Matsuoka D, Matsumoto A
- Journal Title
  
  Mol Cell Biochem.
  
  Volume: 477 Issue: 1 Pages: 99-104
- DOI
  10.1007/s11010-021-04262-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11627
[Journal Article] Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-42021
- Author(s)
  Saitoh Yasukazu、Kawasaki Naho、Eguchi Natsumi、Ikeshima Minoru
- Journal Title
  
  Free Radical Research
  
  Volume: 55 Issue: 3 Pages: 211-220
- DOI
  10.1080/10715762.2021.1902514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11627
[Journal Article] Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-42021
- Author(s)
  Yasukazu Saitoh, Naho Kawasaki, Natsumi Eguchi, and Minoru Ikeshima
- Journal Title
  
  Free radical res.
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11627
[Journal Article] Protective Effects of Polyvinylpyrrolidone-Wrapped Fullerene Against Nitric Oxide/Peroxynitrite-Induced Cellular Injury in Human Skin Keratinocytes2021
- Author(s)
  Saitoh Yasukazu、Tanaka Asuka、Hyodo Sayuri
- Journal Title
  
  Journal of Nanoscience and Nanotechnology
  
  Volume: 21 Issue: 9 Pages: 4579-4585
- DOI
  10.1166/jnn.2021.19279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11627
[Journal Article] Carcinostatic effects of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the esterolytically resultant ascorbate by hydrogen2021
- Author(s)
  Kato Shinya、Saitoh Yasukazu、Miwa Nobuhiko
- Journal Title
  
  Human Cell
  
  Volume: 34 Issue: 2 Pages: 436-444
- DOI
  10.1007/s13577-020-00462-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11627
[Journal Article] Protective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and glyoxal-induced injuries to human skin keratinocytes2021
- Author(s)
  Saitoh Yasukazu、Yamaguchi Yuuki、Okada Yuhei
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 476 Issue: 10 Pages: 3613-3622
- DOI
  10.1007/s11010-021-04189-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11627
[Journal Article] Resveratrol potentiates intracellular ascorbic acid enrichment through dehydroascorbic acid transport and/or its intracellular reduction in HaCaT cells.2020
- Author(s)
  Saitoh Y, Umezaki T, Yonekura N, Nakawa A
- Journal Title
  
  Mol Cell Biochem.
  
  Volume: 467 Issue: 1-2 Pages: 57-64
- DOI
  10.1007/s11010-020-03700-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01862
[Journal Article] Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles.2019
- Author(s)
  Asada R, Saitoh Y, Miwa N
- Journal Title
  
  Med Gas Res.
  
  Volume: 9 Issue: 2 Pages: 68-73
- DOI
  10.4103/2045-9912.260647
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01862
[Journal Article] 高濃度アスコルビン酸は過酸化水素およびスーパーオキシドアニオンラジカルによる細胞死誘導と増殖抑制を介してヒト舌がん細胞における抗がん効果を発揮する2018
- Author(s)
  大和田凌平、小関祐、齋藤靖和
- Journal Title
  
  ビタミン
  
  Volume: 92 (5-6) Pages: 267-269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01862
[Journal Article] Resveratrol oligosaccharides induces mRNA expression for SIRT.2018
- Author(s)
  Hamada H, Shimoda K, Saitoh Y, Doi S, Fujitaka Y, Ono T, Hamada H, Araki M
- Journal Title
  
  Natural product communications
  
  Volume: 13(4) Pages: 455-456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01862
[Journal Article] Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does.2018
- Author(s)
  Tanaka Y, Saitoh Y, Miwa N
- Journal Title
  
  Med Gas Res.
  
  Volume: 8(1) Issue: 1 Pages: 12-18
- DOI
  10.4103/2045-9912.229598
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01862
[Journal Article] The influence of cellular senescence on intracellular vitamin C transport, accumulation, and function.2018
- Author(s)
  Saitoh Y, Nakawa A, Tanabe T, Akiyama T
- Journal Title
  
  Mol Cell Biochem.
  
  Volume: 446(1-2) Issue: 1-2 Pages: 209-219
- DOI
  10.1007/s11010-018-3287-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01862
[Journal Article] Comments to the article "Artefacts with ascorbate and other redox-active compounds in cell culture: epigenetic modifications, and cell killing due to hydrogen peroxide generation in cell culture media".2018
- Author(s)
  Saitoh Y
- Journal Title
  
  Free Radic Res.
  
  Volume: 52(9) Issue: 9 Pages: 910-912
- DOI
  10.1080/10715762.2018.1524891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01862
[Journal Article] ヒト線維芽細胞の老化に伴う細胞内酸化ストレスの増加とアスコルビン酸必要性の亢進2014
- Author(s)
  斉藤靖和、森下愛子、水戸智美、辻屋翼、三羽信比古
- Journal Title
  
  ビタミン
  
  Volume: 88 Pages: 287-288
- NAID
  110009823438
- Data Source
  KAKENHI-PROJECT-26450163
[Journal Article] Senescence-induced increases in intracellular oxidative stress and enhancement of the need for ascorbic acid in human fibroblasts2013
- Author(s)
  SaitohY, MorishitaA, MitoS, TsujiyaT, MiwaN
- Journal Title
  
  Molecular and Cellular Biochemistry
- NAID
  110009823438
- Data Source
  KAKENHI-PROJECT-23700838
[Journal Article] Senescence-induced increases in intracellular oxidative stress and enhancement of the need for ascorbic acid in human fibroblasts2013
- Author(s)
  Yasukazu Saitoh
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 未決定 Issue: 1-2 Pages: 129-141
- DOI
  10.1007/s11010-013-1666-y
- NAID
  110009823438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700838
[Journal Article] Fullerene-C60 incorporated in liposome exerts persistent hydroxyl radical-scavenging activity and cytoprotection in UVA/B-irradiated keratinocytes.2011
- Author(s)
  Kato S, Aoshima H, Saitoh Y, Miwa N.
- Journal Title
  
  J Nanosci Nanotechnol.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Anticancer effects of fullerene [C_60] included in polyethylene glycol combined with visible light-irradiation through ROS generation and DNA fragmentation on fibrosarcoma cells with scarce cytotoxicity to normal fibroblasts.2011
- Author(s)
  Liao F, Saitoh Y, Miwa N.
- Journal Title
  
  Oncol Res.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages.2011
- Author(s)
  Saitoh Y, Miyanishi A, Mizuno H, Kato S, Aoshima H, Kokubo K, Miwa N.
- Journal Title
  
  J Photochem Photobiol B.
  
  Volume: Vol.102(1) Pages: 69-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Fullerene-C60/liposome complex : Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue.2010
- Author(s)
  Kato S, Aoshima H, Saitoh Y, Miwa N.
- Journal Title
  
  J Photochem Photobiol B.
  
  Volume: Vol.98(1) Pages: 99-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] 新規素材の美肌・抗老化・抗メタボ効能に関する化粧品・美肌サプリメントとしての研究開発動向～主に水素・白金・フラーレン・プロビタミンC/E・炭酸ガス・天然系抗酸化剤について～2010
- Author(s)
  斉藤靖和, 加藤信哉, 肖黎(Xiao Li), 三羽信比古
- Journal Title
  
  Cosmetic Stage
  
  Volume: 5巻 Pages: 47-62
- NAID
  40017367004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Defensive effects of fullerene-C60/liposome complex against UVA-induced intracellular reactive oxygen species generation and cell death in human skin keratinocytes HaCaT, associated with intracellular uptake and extracellular excretion of fullerene-C60.2010
- Author(s)
  Kato S, Kikuchi R, Aoshima H, Saitoh Y, Miwa N
- Journal Title
  
  J Photochem Photobiol B.
  
  Volume: Vol.98(2) Pages: 144-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system.2010
- Author(s)
  Xiao L, Aoshima H, Saitoh Y, Miwa N.
- Journal Title
  
  Biomaterials.
  
  Volume: Vol.31 Pages: 5976-5985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Defensive effects of fullerene-C60 dissolved in squalane against the 2, 4-nonadienal-induced cell injury in human skin keratinocytes HaCaT and wrinkle formation in 3D-human skin tissue model.2010
- Author(s)
  Kato S, Aoshima H, Saitoh Y, Miwa N
- Journal Title
  
  J Biomed Nanotechnol
  
  Volume: Vol.6 Pages: 52-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Fullerene-polyvinylpyrrolidone clathrate localizes in the cytoplasm to prevent Ultraviolet-A ray-induced DNA-fragmentation and activation of the transcriptional factor NF-kappa B.2010
- Author(s)
  Xiao L, Aoshima H, Saitoh Y, Miwa N
- Journal Title
  
  J Cell Biochem.
  
  Volume: Vol.111(4) Pages: 955-966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Clinical Evaluation of Fullerene-C60 Dissolved in Squalane for Anti-Wrinkle Cosmetics.2010
- Author(s)
  Kato S, Aoshima H, Saitoh Y, Miwa N.
- Journal Title
  
  J Nanosci Nanotechnol.
  
  Volume: Vol.10 Pages: 6769-6774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Novel polyhydroxylated fullerene suppresses intracellular oxidative stress together with repression of intracellular lipid accumulation during the differentiation of OP9 preadipocytes into adipocytes.2010
- Author(s)
  Saitoh Y, Xiao L, Mizuno H, Kato S, Aoshima H, Taira H, Kokubo K, Miwa N
- Journal Title
  
  Free Radical Research
  
  Volume: Vol.44(9) Pages: 1072-1081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Biological safety of Liposome Fullerene consisting of hydrogenated lecithin, glycine soja sterols and fullerene-C60 upon photocytotoxicity and bacterial reverse mutagenicity2009
- Author(s)
  Kato Shinya, Aoshima Hisae Saitoh Yasukazu, Miwa Nobuhiko
- Journal Title
  
  Toxicology & Industrial Health 25(3)
  
  Pages: 197-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Highly-hydroxylated or γ-cyclodextrin-bicapped water-soluble derivative of fullerene : the antioxidant ability assessed by electron spin resonance method and β-carotene bleaching assay2009
- Author(s)
  Kato Shinya, Aoshima Hisae, Saitoh Yasukazu, Miwa Nobuhiko
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 19
  
  Pages: 5293-5296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Biological safety of LipoFullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and the permeability into the human skin tissue2009
- Author(s)
  Kato Shinya, Aoshima Hisae, Saitoh Yasukazu, Miwa Nobuhiko
- Journal Title
  
  Basic & Clinical Pharmacology & Toxicology 104(6)
  
  Pages: 483-487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Safety evaluation of highly purified fullerenes : based on screening of eye, skin and cell damages2009
- Author(s)
  Kato Shinya, Aoshima Hisae, Saitoh Yasukazu, Ito Shinobu, Yamana Shuichi, Miwa Nobuhiko
- Journal Title
  
  Journal of Toxicological Sciences 34(5)
  
  Pages: 555-562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590099
[Journal Article] Transfection with glutathione-dependent dehydroascorbate reductase genes exerts cytoprotective effects against hydroperoxide-induced cell injury through vitamin C re eneration and oxidative-stress diminishment2007
- Author(s)
  Saitoh Y, Fukuoka Y, Nishikimi M, Miwa N
- Journal Title
  
  Gene Therapy & Molecular Biology 11
  
  Pages: 143-150
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] Transfection with glutathione-dependent dehydroascoibate reductase genes exerts cytoprotective effects against hydroperoxide-induced cell injury through vitamin C regeneration and oxidalive-stress diminishment2007
- Author(s)
  Saitoh Y, Fukuoka Y, Nishikimi M, Miwa N
- Journal Title
  
  Gene Therapy & Molecular Biology 11
  
  Pages: 143-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] Transfection with glutathione-dependent dehydroascorbate reductase genes exerts cytoprotective effects against hydroperoxide-induced cell injury through vitamin C regeneration and oxidative-stress diminishment2007
- Author(s)
  Saitoh Y, Fukuoka Y, Nishilcimi M, Miwa, N
- Journal Title
  
  (Reviewed) Vol. 11(Reviewed)
  
  Pages: 143-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] Apoptosis prevention in neuronally differentiated PC12 cells,by bcl-2 gene trausfection in the non-proliferative and differentiated state,with retention of neuron-specific proteins and blockage of mitocondrion-relayed apoptotic pathway2007
- Author(s)
  Saitoh Y, Masumoto S, Yanada S, Miwa N
- Journal Title
  
  Gene Therapy & Molecular Biology 11
  
  Pages: 275-288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] Apoptosis prevention in neuronally differentiated PC12 cells,by bcl-2 gene transfection in the non-proliferative and differentiated state,with retention of neuron-specific proteins and blockage of mitocondrion-relaed apoptotic pathway2007
- Author(s)
  Saitoh Y, Masumoto S, Yanada S, Miwa N
- Journal Title
  
  Gene Therapy & Molecular Biology 11
  
  Pages: 275-288
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] Apoptosis prevention in neuronally differentiated PC12 cells, by bcl-2 gene transfection in the non-proliferative and differentiated state, with retention of neuron-specific proteins and blockage of mitocondrion-relayed apoptotic pathway2007
- Author(s)
  Saitoh Y, Masumoto S, Yanada S, Miwa, N
- Journal Title
  
  (Reviewed) Vol. 11(Reviewed)
  
  Pages: 275-288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] Transfection of the anti-apoptotic gene bc1-2 inhibits oxidative stress-induced cell injuries through delaying of NF-kB activation2006
- Author(s)
  Shinobu, Yanada, Masashi, Misurni, Yasukazu, Saitoh, Yasufumi, Kaneda, Nobuhiko, Miwa
- Journal Title
  
  (Reviewed) Vol. 10(Reviewed)
  
  Pages: 269-276
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] Transfection of the anti-apoptotic gene bcl-2 inhibits oxidative stress-induced cell injuries through delaying of NF-kB activation.2006
- Author(s)
  Shinobu Yanada, Masashi Misumi, Yasukazu Saitoh, Yasufumi Kaneda, Nobuhiko Miwa
- Journal Title
  
  Gene Therapy ＆ Molecular Biology 10巻
  
  Pages: 269-276
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] Transfection of the anti-apoptotic gene bcl-2 inhibits oxidative stress-induced cell injuries through laying of NF-kB activation"2006
- Author(s)
  Shinobu Yanada, Masashi Misumi, Yasukazu Saitoh, Yasufumi Kaneda, Nobuhiko Miwa
- Journal Title
  
  Gene Therapy & Molecular Biology 10巻
  
  Pages: 269-276
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590064
[Journal Article] Anti-wrinkle activity of vitamin C derivatives and the molecular mechanism2006
- Author(s)
  Kawamura T, Saitoh Y, Kato E, Tsuzuki T, Miwa, N
- Journal Title
  
  Anti-aging series "Front-line of Skin Anti-aging Research"(NTS Publishing Co.) Vol. 2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590064
[Presentation] ヒト老化細胞に対するビタミンCおよびその誘導体のSenostatic (Senomorphic)効果2025
- Author(s)
  齋藤靖和，角尾麻伊，萩山由衣，中村太紀，岩本大輝，福田大智
- Organizer
  日本薬学会第145年会
- Data Source
  KAKENHI-PROJECT-23K10922
[Presentation] フェアリー化合物(2-aza-8-oxohypoxanthine)の色素細胞に対する紫外線傷害防御効果2025
- Author(s)
  青島央江、水野琉加、大西史織、河岸洋和、齋藤靖和
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-23K10922
[Presentation] 老化細胞誘導方法の違いによるヒト線維芽細胞の遺伝子発現パターンの差異2024
- Author(s)
  齋藤靖和、角尾麻伊、萩山由衣、中村太紀、岩本大輝、福田大智
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K10922
[Presentation] ヒト線維芽細胞におけるビタミンCおよびその誘導体による老化制御 (Senotherapy)の可能性2024
- Author(s)
  齋藤靖和，角尾麻伊，萩山由衣，中村太紀，岩本大輝，福田大智
- Organizer
  第24回抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-23K10922
[Presentation] 酸化ストレス制御という視点からの皮膚防護、抗がん、抗老化を目指したアプローチ2024
- Author(s)
  齋藤靖和
- Organizer
  広島バイオテクノロジー推進協議会第14回Web講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K10922
[Presentation] 老化細胞誘導方法の違いによる遺伝子発現パターンの差異について（複製老化 vs ストレス老化）2023
- Author(s)
  齋藤靖和、角尾麻伊、中村太紀、岩本大輝、福田大智
- Organizer
  第23回抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-23K10922
[Presentation] ヒト皮膚表皮細胞HaCaTにおける紫外線誘導性細胞傷害に対するスチルベン化合物とそれら誘導体の防御効果2023
- Author(s)
  齋藤靖和、金輪静夏、野原鞠、脇田有瑳、山口諒子、池田千夏、濱田博喜
- Organizer
  日本薬学会第143年会（札幌）
- Data Source
  KAKENHI-PROJECT-20K11627
[Presentation] 脂肪酸前処理はヒト表皮角化細胞の酸化ストレス抵抗性を増強する2023
- Author(s)
  篠﨑颯将、坂本陽、齋藤靖和
- Organizer
  第76回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-23K10922
[Presentation] 高濃度アスコルビン酸と金属の併用は活性酸素種(ROS)の発生増加を介してヒト線維肉腫細胞HT-1080への細胞傷害を増強する2023
- Author(s)
  竹田真奈斗、上田舜、齋藤靖和
- Organizer
  第76回日本酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-23K10922
[Presentation] ヒト線維芽細胞におけるスチルベン化合物とそれら誘導体の抗老化作用2022
- Author(s)
  齋藤靖和，福田大智，岩本大輝，田邊朝弓，金井直人，濱田博喜
- Organizer
  日本薬学会第142年会（名古屋）
- Data Source
  KAKENHI-PROJECT-20K11627
[Presentation] ヒト線維芽細胞におけるスチルベン化合物の抗老化作用の可能性2022
- Author(s)
  齋藤靖和，福田大智，岩本大輝，田邊朝弓，金井直人，濱田博喜
- Organizer
  日本農芸化学会2022年度大会（京都）
- Data Source
  KAKENHI-PROJECT-20K11627
[Presentation] 高濃度アスコルビン酸によるヒト線維肉腫細胞の増殖抑制/殺傷および浸潤抑制効果2021
- Author(s)
  上田　舜，谷村　友翼，古畑　朋也，福喜多　優介，齋藤　靖和
- Organizer
  日本薬学会第141年会（広島）
- Data Source
  KAKENHI-PROJECT-20K11627
[Presentation] ヒト皮膚表皮細胞HaCaTにおけるcumene hydroperoxide誘導性細胞傷害に対するスチルベン誘導体の防御効果2021
- Author(s)
  齋藤　靖和，脇田　有瑳，山口　諒子，金輪　静夏, 野原　鞠，濱田博喜
- Organizer
  第74回日本酸化ストレス学会・第21回日本NO学会合同学術集会（仙台）
- Data Source
  KAKENHI-PROJECT-20K11627
[Presentation] 老化ヒト線維芽細胞におけるスチルベン誘導体のSenostatic効果2021
- Author(s)
  齋藤靖和，福田大智，岩本大輝，田邊朝弓，濱田博喜
- Organizer
  第21回日本抗加齢医学会総会（京都）
- Data Source
  KAKENHI-PROJECT-20K11627
[Presentation] レスベラトロールおよびその類縁体による酸化ストレス性細胞傷害防御効果～その有効性と細胞老化の関係～2020
- Author(s)
  齋藤靖和，福田大智，今本早紀，田邊朝弓，秋山岳生，濱田博喜
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K01862
[Presentation] 高濃度アスコルビン酸によるヒト線維肉腫細胞の増殖抑制/殺傷効果とそのメカニズム2020
- Author(s)
  谷村　友翼，福喜多　優介，古畑　朋也，齋藤　靖和
- Organizer
  第73回日本酸化ストレス学会学術集会（米子）
- Data Source
  KAKENHI-PROJECT-20K11627
[Presentation] 細胞老化随伴分泌現象(SASP)が非老化細胞の細胞機能へ与える影響2019
- Author(s)
  齋藤靖和，福田大智，今本早紀，田邊朝弓，秋山岳生
- Organizer
  第19回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17K01862
[Presentation] ヒト皮膚表皮細胞HaCaTの脂質過酸化傷害に対するスチルベン誘導体の防御効果2019
- Author(s)
  齋藤　靖和，山口　諒子，金輪　静夏, 脇田　有瑳, 濱田博喜
- Organizer
  第72回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K01862
[Presentation] 細胞老化随伴分泌現象(SASP)が非老化細胞の細胞機能へ与える影響2019
- Author(s)
  齋藤靖和，福田大智，今本早紀，田邊朝弓，秋山岳生
- Organizer
  第19回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17K01862
[Presentation] ヒト線維芽細胞TIG-1における酸化ストレス傷害防御効果に対する細胞老化の影響2019
- Author(s)
  福田　大智，齋藤　靖和，濱田博喜
- Organizer
  第72回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K01862
[Presentation] 高濃度アスコルビン酸によるヒト胃がん細胞の増殖抑制/殺傷効果とそのメカニズム2018
- Author(s)
  竹田香央里，小関祐，福喜多優介，大河内公一，齋藤靖和
- Organizer
  第71回日本酸化ストレス学会第18回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-17K01862
[Presentation] ヒト線維芽細胞の細胞老化に伴う酸化ストレス抵抗性の変化2018
- Author(s)
  齋藤靖和，今本早紀，田邊朝弓，福田大智，水島ひかる，秋山岳生
- Organizer
  第18回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17K01862
[Presentation] ヒト線維芽細胞の細胞老化に伴う酸化ストレス抵抗性の変化2018
- Author(s)
  齋藤靖和，今本早紀，田邊朝弓，福田大智，水島ひかる，秋山岳生
- Organizer
  第18回日本抗加齢医学会総会（大阪）
- Data Source
  KAKENHI-PROJECT-17K01862
[Presentation] 線維芽細胞由来senescence-associated secretory phenotype(SASP)がメラニン産生に与える影響2017
- Author(s)
  斉藤靖和，渡辺祥子，江川彩子，上月信之介
- Organizer
  第17回日本抗加齢医学会総会（東京）
- Data Source
  KAKENHI-PROJECT-17K01862
[Presentation] ヒト細胞老化に伴う細胞内ビタミンC輸送・蓄積能の変化とそのメカニズム2017
- Author(s)
  斉藤靖和，中和篤，梅﨑大樹，田邊朝弓，秋山岳生
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-26450163
[Presentation] ヒト上皮細胞と線維芽細胞におけるビタミンC輸送特性の違い2016
- Author(s)
  中和篤，江川彩子，梅﨑大樹，小関祐，斉藤靖和
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26450163
[Presentation] ヒト細胞老化に伴う細胞内ビタミンC量の違いとそのメカニズム2016
- Author(s)
  斉藤靖和, 江川彩子，今本早紀，中和篤
- Organizer
  第16回日本抗加齢医学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-26450163
[Presentation] ヒト線維芽細胞OUMS-36の細胞老化に伴う酸化ストレス応答性およびビタミンC要求性の変化2012
- Author(s)
  斉藤靖和,森下愛子,水戸智美,三羽信比古
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23700838
[Presentation] ヒト線維芽細胞OUMS-36の細胞老化に伴う酸化ストレス応答性およびビタミンC要求性の変化2012
- Author(s)
  斉藤靖和，森下愛子，水戸智美，三羽信比古
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-23700838
[Presentation] リポソーム包含フラーレンの抗酸化活性:UVA/B照射下でのヒドロキシルラジカル消去活性、細胞死防御、β-カロテン退色防御効果Antioxidant activity of fullerenes/liposome complex by ESR under UVA/B irradiation, cytoprotective effect, and β-carotene bleaching method.2010
- Author(s)
  加藤信哉, 青島央江, 平良光, 山名修一, 斉藤靖和, 三羽信比古
- Organizer
  日本香粧品学会
- Place of Presentation
  有楽町朝日ホール(東京都)
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-21590099
[Presentation] PVP包接フラーレンとプロビタミンC(AA2G),アスタキサンチンの併用による抗酸化効果および紫外線傷害抑制効果Combinational Effects of PVP/C_60 and AA2G or Astaxanthin on Antioxidant Activity and UV Irradiation-induced Cell Injuries.2010
- Author(s)
  斉藤靖和, 加藤信哉, 角井雅之, 青島央江, 平良光, 山名修一, 三羽信比古
- Organizer
  日本香粧品学会
- Place of Presentation
  有楽町朝日ホール(東京都)
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-21590099
[Presentation] 無作為化二重盲検マッチドペア比較試験によるフラーレンのシワ改善効果の検証2010
- Author(s)
  青島央江, 伊藤雅之, 平良光, 加藤信哉, 斉藤靖和, 三羽信比古
- Organizer
  日本抗加齢医学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-21590099
[Presentation] リポソーム包含フラーレンによる紫外線A波防御効果～ヒト皮膚角化細胞の細胞死防御および3D皮膚モデルでの肌保護効果～2009
- Author(s)
  加藤信哉, 青島央江, 平良光, 山名修一, 斉藤靖和, 三羽信比古
- Organizer
  日本香粧品学会
- Place of Presentation
  ヤクルトホール(東京都)
- Year and Date
  2009-06-09
- Data Source
  KAKENHI-PROJECT-21590099
[Presentation] 新規3次元セルライト皮膚モデルを用いた高度水酸化フラーレンのリンパ様細胞U937活性化抑制効果の検証2009
- Author(s)
  肖黎, 青島央江, 平良光, 山名修一, 斉藤靖和, 三羽信比古
- Organizer
  日本香粧品学会
- Place of Presentation
  ヤクルトホール(東京都)
- Year and Date
  2009-06-09
- Data Source
  KAKENHI-PROJECT-21590099
[Presentation] 亜鉛およびレスベラトロールがビタミンC輸送に与える影響
- Author(s)
  中和篤，青山あゆみ，大和嬉子，斉藤靖和
- Organizer
  日本ビタミン学会
- Place of Presentation
  姫路商工会議所（兵庫県姫路市）
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-26450163

1. MIWA Nobuhiko (00142141)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
2. XIAO Li (10405516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 河地信哉 (70438290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. GAN Xuehui (20405517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 谷孝二 (30405518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 河岸洋和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 伊藤英人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saitoh Yasukazu 齋藤 靖和

SAITOH Yasukazu 斉藤 靖和

齋藤 靖和 サイトウ ヤスカズ

斉藤 靖和 サイトウ ヤスカズ

Research Projects

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Co-Researchers

Senostatics効果をもつ食品由来成分の探索から迫る老化細胞制御Principal Investigator

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Control of senescent cells based on the elucidation of the relationship between SASP and stressPrincipal Investigator

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A study on the ways to alleviate senescence-associated secretory phenotypePrincipal Investigator

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Study on active intervention for protecting senescent cells based on the mechanism of changes in stress resistance accompanying cellular senescencePrincipal Investigator

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Study on cellular senescence-induced changes in vitamin C transport/accumulation activity and its regulation mechanismPrincipal Investigator

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Elucidation of the relationships between senescence-associated decreases in ascorbic acid level and senescence-associated changes in cellular functionsPrincipal Investigator

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フラーレン各種誘導体の化学構造と抗酸化活性との相関性に関する体系的解析

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Enhancing effects of vitamin C-regeneration gene and vitamin C recycling on prevention of cell death

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[Book] 遠藤 守信、飯島 澄男 編「ナノカーボンハンドブック」第2編、第3章、3-2-6節フラーレン誘導体の抗酸化作用と細胞死抑制効果および医療応用2007

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[Book] 「抗しわ活性ビタミンC誘導体と分子メカニズム, アンチ・エイジングシリーズ第2巻「皮膚の抗老化最前線」第3部、第1章、第2-2節2006

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[Book] 「抗しわ活性ビタミンC誘導体と分子メカニズム」アンチ・エイジングシリーズ第2巻「皮膚の抗老化最前線」ISBN4-86043-104-9 C3047, 第3部・第1章・第2-2節,pp.201-2302006

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[Journal Article] High dose of ascorbic acid induces selective cell growth inhibition and cell death in human gastric signet-ring cell carcinoma-derived NUGC-4 cells2025

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[Journal Article] 複製老化細胞とストレス老化細胞は同質なのか？～老化誘導方法の違いによる表現型と遺伝子発現パターンの差異～2025

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[Journal Article] Inhibitory Effect of 2-Aza-8-oxohypoxanthine on Tyrosinase Activity and Melanin Production2024

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Saitoh Yasukazu 齋藤靖和

SAITOH Yasukazu 斉藤靖和

齋藤靖和サイトウヤスカズ

斉藤靖和サイトウヤスカズ

[Book] 遠藤守信、飯島澄男編「ナノカーボンハンドブック」第2編、第3章、3-2-6節フラーレン誘導体の抗酸化作用と細胞死抑制効果および医療応用2007