SUDA Megumi 須田恵

Researcher Number	90415969
Other IDs
Affiliation (based on the past Project Information) *help	2016: 独立行政法人労働者健康安全機構労働安全衛生総合研究所, 産業毒性・生体影響研究グループ, 上席研究員 2014 – 2015: 独立行政法人労働安全衛生総合研究所, その他部局等, 研究員 2013: 独立行政法人労働安全衛生総合研究所 2013: 独立行政法人労働安全衛生総合研究所, 健康障害予防研究グループ, 研究員 2011 – 2012: 独立行政法人労働安全衛生総合研究所, 健康障害予防研究グループ, 主任研究員 … More 2007: National Institute of Occupational Safety and Health, Hazard Evaluation and Epidemiology Research Group, Senior Researcher 2007: 独立行政法人労働安全衛生総合研究所(産業医学総合研究所), 有害性評価研究グループ, 主任研究員 2006: 独立行政法人労働安全衛生総合研究所(産業医学総合研究所), 健康障害予防研究グループ, 主任研究員 2002 – 2005: 独立行政法人産業医学総合研究所, 健康障害予防研究部, 研究員 Less
Review Section/Research Field	Except Principal Investigator Hygiene / Hygiene / Hygiene and public health
Keywords	Except Principal Investigator organic solvent / ethylene glycol monoethyl ether / glycol ethers / グリコール誘導体 / ALDH2 / 遺伝子多型 / 遺伝毒性 / transgenic mouse / Aldh2 / reproductive toxicity … More / エチレングリコールモノエチル / 精子運動能 / ノックアウトマウス / ALDH2遺伝子 / エチルセロソルブ / 遺伝子ノックアウトマウス / ALDH2酵素 / 生殖毒性 / エチレングリコールモノエチルエーテル / genetic polymorphisms / health effect / toxicity / 国際研究者交流 / 健康影響 / 毒性 / 有機溶剤 / セロソルブ / CYP2E1 / 代謝 / １,２－ジクロロプロパン / 活性酸素種 / ヒストンH2AXリン酸化 / 代謝活性化 / 1,2-ジクロロプロパン / 職業性胆管癌 / 感受性 / 毒性評価 / バイオ燃料 / 国際情報交換 / 代謝酵素 / ETBE Less

Study on the metabolic activation and genotoxic effects of chlorinated organic solvents
- Principal Investigator
  
  Wang Rui-Sheng
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  National Institute of Occupational Safety and Health,Japan
Health effects of the biofuel ETBE as modified by the genetic polymorphisms of its metabolizing enzyme
- Principal Investigator
  
  WANG Rui-Sheng
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  National Institute of Occupational Safety and Health, Japan
Study on the mechanisms of the reproductive damages caused by glycol ethers using transgenic mouse
- Principal Investigator
  
  WANG Rui-Sheng
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  National Institute of Occupational Safety and Health, Japan
Study on glycol ethers-caused damages in the reproductive and haematopoietic systems and the underlying mechanisms in human
- Principal Investigator
  
  WANG Rui-sheng
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  National Institute of Occupational Safety and Health, Japan

All 2017 2016 2015 2014 2013 2012 2008 2007 2006 2004 2003 Other

All Journal Article Presentation

[Journal Article] 1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism.2017
- Author(s)
  Toyooka T, Yanagiba Y, Suda M, Ibuki Y, Wang RS.
- Journal Title
  
  Toxicology Letters
  
  Volume: 272 Pages: 60-67
- DOI
  10.1016/j.toxlet.2017.03.009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06893, KAKENHI-PROJECT-26460817
[Journal Article] Alteration of brain levels of neurotransmitters and amino acids in male F344 rats induced by three-week repeated inhalation exposure to 1-bromopropane2008
- Author(s)
  Megumi Suda, Takeshi Honma, Muneyuki Miyagawa, Rui-Sheng Wang.
- Journal Title
  
  Industrial Health 46
  
  Pages: 348-359
- NAID
  130004828517
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590529
[Journal Article] Alteration of brain levels of neurotransmitters and amino acids in male F344 rats induced by three-week repeated inhalation exposure to 1-bromopropane2008
- Author(s)
  Megumi Suda
- Journal Title
  
  Industrial Health 46
  
  Pages: 348-359
- NAID
  130004828517
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590529
[Journal Article] Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Knockout Mice.2007
- Author(s)
  Rui-Sheng Wang, Katsumi Ohtani, Megumi Suda, Kyoko Kitagawa, Keiichi Nakayama, Toshihiro Kawamoto, Tamie Nakajima.
- Journal Title
  
  Industrial Health 45
  
  Pages: 574-578
- NAID
  130004828493
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590529
[Journal Article] Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Kno ckout Mice2007
- Author(s)
  Rui-Sheng Wang, Katsumi Ohtani, Megumi Suda, Kyoko Kitagawa, Ketiichi Nakayama, Toshihiro Kawamoto and Tamie Nakajima
- Journal Title
  
  Industrial Healty 45
  
  Pages: 574-578
- NAID
  130004828493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590529
[Journal Article] Inhibitory Effect of Ethylene Glycol Monoethyl Ether on Rat Sperm Motion.2006
- Author(s)
  Rui-Sheng Wang, Katsumi Ohtani, Megumi Suda, Tamie Nakajima.
- Journal Title
  
  Industrial Health 44
  
  Pages: 665-668
- NAID
  130004828480
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590529
[Journal Article] Health effects of exposure to ethylene glycol monoethyl ether in female workers.2004
- Author(s)
  Rui-Sheng Wang, Megumi Suda, Xing Gao, Bingling Wang, Tamie Nakajima, Takeshi Honma
- Journal Title
  
  Industrial Health 42
  
  Pages: 447-451
- NAID
  130003551170
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570317
[Journal Article] Imbalance of testosterone level in male offspring rats perinatally exposed to bisphenol A.2003
- Author(s)
  Sumiko Watanabe, Rui-Sheng Wang, Muneyuki Miyagawa, Kenichi Kobayashi, Megumi Suda, Soichiro Sekiguchi, Takeshi Honma
- Journal Title
  
  Industrial Health 41
  
  Pages: 338-341
- NAID
  130003551108
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570317
[Presentation] 1,2-Dichloropropane and its metabolites display genotoxicity in human liver- and bile duct-derived cells2016
- Author(s)
  R.S. Wang, T. Toyooka, Y. Yanagiba, M. Suda
- Organizer
  14th International Congress of Toxicology
- Place of Presentation
  Merida, Mexico
- Year and Date
  2016-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] Detection of DNA double-strand breaks in the liver of mice exposed to 1,2-dichloropropane2016
- Author(s)
  Rui-Sheng Wang, Tatsushi Toyooka, Yukie Yanagiba and Megumi Suda
- Organizer
  The 55th Annual Meeting of the Society of Toxicology
- Place of Presentation
  ルイジアンナ州ニューオーリンズ市
- Year and Date
  2016-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] Intermediate metabolites of 1,2-dichloropropane are responsible for the genotoxic effects in mice2016
- Author(s)
  Rui-Sheng Wang, Yukie Yanagiba, Tatsushi Toyooka and Megumi Suda
- Organizer
  52nd European Congress of the European Societies of Toxicology
- Place of Presentation
  Seville, Spain
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] インビトロ及びインビボにおける1,2-ジクロロプロパンのDNA損傷について2016
- Author(s)
  王　瑞生，豊岡達士，柳場由絵，須田　恵
- Organizer
  第89回日本産業衛生学会
- Place of Presentation
  福島市
- Year and Date
  2016-05-24
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] 1,2-ジクロロプロパン曝露時の血液・胆汁中の代謝物濃度の比較2016
- Author(s)
  須田　恵，柳場由絵，鈴木哲矢，豊岡達士，王　瑞生
- Organizer
  第44回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  東京
- Year and Date
  2016-08-04
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] Mechanistic Study on the Hepatotoxic Effects of 1,2-Dichloropropane in ALDH2 Knockout Mice2015
- Author(s)
  Rui-Sheng Wang, Tetsuya Suzuki, Yukie Yanagiba, Megumi Suda
- Organizer
  51st Congress of the European Society of Toxixology
- Place of Presentation
  ポルトガル、ポルト市
- Year and Date
  2015-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] 1,2-ジクロロプロパン吸入ばく露後のマウス肝臓におけるDNA損傷について2015
- Author(s)
  王　瑞生，豊岡達士，柳場由絵，須田　恵
- Organizer
  第43回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  愛知県南知多
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26460817
[Presentation] Assessment of the reproductive toxicity of inhalation exposure to Ethyl tertiary Butyl Ether in male mice with normal, low active and inactive ALDH2.2014
- Author(s)
  Rui-Sheng Wang, Zuquan Weng, Katsumi Ohtani, Megumi Suda and Yukie Yanagiba
- Organizer
  The 53rd Annual Meeting of Siciety of Toxicology
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] Assessment of the reproductive toxicity of inhalation exposure to Ethyl tertiary Butyl Ether in male mice with normal, low active and inactive ALDH22014
- Author(s)
  Rui-Sheng Wang, Zuquan Weng, Katsumi Ohtani, Megumi Suda and Yukie Yanagiba
- Organizer
  The 53rs Annual Meeting of the Society of Toxicology, Toxicologist 2014
- Place of Presentation
  (page 442)
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] Enhanced genotoxic effects of ethyl tertiary butyl ether in sperm of Aldh2 gene knockout mice2013
- Author(s)
  Rui-Sheng Wang, Megumi Suda, Katsumi Ohtani, Zuquan Weng
- Organizer
  11th International Conference on Environmental Mutagens
- Place of Presentation
  (Program and Abstract Book, p228)
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] Enhanced genotoxic effects of ethyl tertiary butyl ether in sperm of Aldh2 gene knockout mice.2013
- Author(s)
  Rui-Sheng Wang, Megumi Suda, Katsumi Ohtani, Zuquan Weng
- Organizer
  11th International Conference on Environmental Mutagens
- Place of Presentation
  Brazil
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] ETBE低濃度ばく露後マウスの各種組織におけるDNA損傷について2012
- Author(s)
  王　瑞生, 須田　恵, 大谷勝己, 柳場由絵, 鈴木哲矢
- Organizer
  第４０回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  神奈川県三浦市
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] ETBE低濃度ばく露後マウスの各種組織におけるDNA損傷について2012
- Author(s)
  王瑞生, 須田恵, 大谷勝己, 柳場由絵, 鈴木哲矢
- Organizer
  第40回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  (抄録集,p24)
- Data Source
  KAKENHI-PROJECT-23590766
[Presentation] Effect of ethylene glycol monoethyl ether on sperm in Aldh2 knockout mice.2007
- Author(s)
  Rui-Sheng Wang, Katsumi Ohtani, Megumi Suda, Kyoko Kitagawa, Keiichi Nakayama, Toshihiro Kawamoto, T. amie Nakajima.
- Organizer
  The 11th International Congress of Toxicology
- Place of Presentation
  Montreal, Canada
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590529
[Presentation] セロソルブ曝露による健康影響の男女間比較2007
- Author(s)
  王瑞生, 須田恵
- Organizer
  第80回日本産業衛生学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-17590529
[Presentation] セロソルブ曝露者の健康障害とその発生機序の解明2007
- Author(s)
  王瑞生, 大谷勝巳, 須田恵, 川本俊弘, 那須民江
- Organizer
  第35回有機溶剤中毒研究会等合同大会シンポジウム
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-17590529
[Presentation] Aldh2 遺伝子ノックアウトマスにおける 1,2 -ジクロロプロパンの遺伝毒性について
- Author(s)
  王　瑞生，鈴木哲矢，柳場由絵，須田　恵
- Organizer
  第42回産業中毒・生物学的モニタリング研究会
- Place of Presentation
  松本市
- Year and Date
  2014-10-25 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-26460817

1. WANG Rui-Sheng (10321895)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
2. SUZUKI Tetsuya (20573950)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. YANAGIBA Yukie (90467283)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. HONMA Takeshi (90332402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. WENG Zuquan (10541170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 伊吹裕子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 豊岡達士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SUDA Megumi 須田 恵

Research Projects

Research Products

Co-Researchers

Study on the metabolic activation and genotoxic effects of chlorinated organic solvents

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Health effects of the biofuel ETBE as modified by the genetic polymorphisms of its metabolizing enzyme

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the mechanisms of the reproductive damages caused by glycol ethers using transgenic mouse

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on glycol ethers-caused damages in the reproductive and haematopoietic systems and the underlying mechanisms in human

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alteration of brain levels of neurotransmitters and amino acids in male F344 rats induced by three-week repeated inhalation exposure to 1-bromopropane2008

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Alteration of brain levels of neurotransmitters and amino acids in male F344 rats induced by three-week repeated inhalation exposure to 1-bromopropane2008

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Knockout Mice.2007

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Reproductive Toxicity of Ethylene Glycol Monoethyl Ether in Aldh2 Kno ckout Mice2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Inhibitory Effect of Ethylene Glycol Monoethyl Ether on Rat Sperm Motion.2006

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Health effects of exposure to ethylene glycol monoethyl ether in female workers.2004

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Imbalance of testosterone level in male offspring rats perinatally exposed to bisphenol A.2003

Author(s)

Journal Title

NAID

Description

Data Source

[Presentation] 1,2-Dichloropropane and its metabolites display genotoxicity in human liver- and bile duct-derived cells2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

SUDA Megumi 須田恵