Kawakami Masanori 川上正敬

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KAWAKAMI Masanori 川上正敬

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Researcher Number	90438648
Affiliation (Current)	2026: 東京大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京大学, 医学部附属病院, 講師 2020 – 2022: 東京大学, 医学部附属病院, 助教 2021: 東京大学, 医学部附属病院, 特任講師 2013: 東京大学, 医学部附属病院, 特任臨床医 2012 – 2013: 東京大学, 医学部附属病院, その他
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / 0901:Oncology and related fields / Laboratory medicine / Clinical oncology
Keywords	Principal Investigator 肺癌 / 過剰中心体 / anaphase catastrophe / 多極性細胞分裂 / トランスジェニックマウス / 分子標的治療 / 小細胞肺癌 / KIFC1 / 染色体不安定性 / サイクリン依存性キナーゼ2 / サイクリン依存性キナーゼ２ / キメラmRNA

KIFC1を標的とした過剰中心体収束阻害による小細胞肺癌治療戦略の開発Principal Investigator
- Principal Investigator
  
  川上正敬
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
Identification of novel therapeutic targets for cancer by inhibiting supernumerary centrosome clusteringPrincipal Investigator
- Principal Investigator
  
  Kawakami Masanori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
Targeting supernumerary centrosomes clustering by CDK2 inhibition to combat lung cancerPrincipal Investigator
- Principal Investigator
  
  Kawakami Masanori
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  The University of Tokyo
肺癌個別化医療実現へ向け過剰発現キナーゼ検出法確立とシグナル経路のプロテオミクスPrincipal Investigator
- Principal Investigator
  
  KAWAKAMI Masanori
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  The University of Tokyo
肺癌で過剰発現するチロシンキナーゼと機能の総合的解析と臨床標本における検出法確立Principal Investigator
- Principal Investigator
  
  KAWAKAMI Masanori
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Clinical oncology
- Research Institution
  The University of Tokyo

All 2025 2024 2023 2021 2020 2013 2012

All Journal Article Presentation

[Journal Article] CDK2 Inhibition Produces a Persistent Population of Polyploid Cancer Cells.2025
- Author(s)
  Tyutyunyk-Massey L, Chen Z, Liu X, Kawakami M, Harned A, Ng Y, Luke B, Okpechi SC, Ogunlade B, Alfaro-Mora Y, Weigert R, Narayan K, Liu X, Dmitrovsky E.
- Journal Title
  
  JCI Insight
  
  Volume: 15 Issue: 10
- DOI
  10.1172/jci.insight.189901
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02776
[Journal Article] CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells2023
- Author(s)
  Chen Z, Liu X, Kawakami M, Liu X, Baker A, Bhatawadekar A, Tyutyunyk-Massey L, Narayan K, Dmitrovsky E.
- Journal Title
  
  Cancer Biol Ther.
  
  Volume: 24 Issue: 1 Pages: 2279241-2279241
- DOI
  10.1080/15384047.2023.2279241
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02776
[Journal Article] A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers2021
- Author(s)
  Kawakami M, Mustachio LM, Chen Y, Chen Z, Liu X, Wei CH, Roszik J, Kittai AS, Danilov AV, Zhang X, Fang B, Wang J, Heymach JV, Tyutyunyk-Massey L, Freemantle SJ, Kurie JM, Liu X, Dmitrovsky E
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 20 Issue: 3 Pages: 477-489
- DOI
  10.1158/1535-7163.mct-19-0987
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22833
[Journal Article] TRIGGERING ANAPHASE CATASTROPHE TO COMBAT ANEUPLOID CANCERS2020
- Author(s)
  Dmitrovsky E, Kawakami M, Liu X, Freemantle SJ, Kurie JM
- Journal Title
  
  Trans Am Clin Climatol Assoc
  
  Volume: 131 Pages: 82-94
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22833
[Journal Article] Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer.2013
- Author(s)
  Kawakami M, Ishikawa R, Amano Y, Sunohara M, Watanabe K, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T, Takai D.
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Issue: 11 Pages: 1447-1454
- DOI
  10.1111/cas.12250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249045, KAKENHI-PROJECT-23390147, KAKENHI-PROJECT-24659267, KAKENHI-PROJECT-25860402
[Journal Article] FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer2013
- Author(s)
  Masanori Kawakami
- Journal Title
  
  International Journal of Clinical and Experimental Pathology
  
  Volume: 6 Pages: 598-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800019
[Presentation] CDK2 Inhibition Produces Persistent Polyploid Cancer Cells with a Survival Advantage2025
- Author(s)
  Tyutyunyk-Massey L, Chen Z, Liu X, Kawakami M, Harned A, Ng Y, Luke B, Okpechi SC, Ogunlade B, Alfaro Y, Weigert R, Narayan K, Liu X, Dmitrovsky E
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2025
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02776
[Presentation] Prevention of centrosome clustering by targeting the motor protein X: A promising therapeutic strategy for small cell lung cancer.2025
- Author(s)
  Nakagawa N, Tokunaga M, Ka M, Sugiura Y, Iida T, Ando T, Kunita A, Watanabe K, Ohta Y, Liu X, Dmitrovsky E, Kage H, Kawakami M
- Organizer
  AACR (American Association for Cancer Research) Annual Meeting 2025
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02316
[Presentation] KIFC1 inhibition elicits antineoplastic activity in small cell lung cancer by inducing anaphase catastrophe2024
- Author(s)
  Nakagawa N, Tokunaga M, Ka M, Sugiura Y, Iida T, Ando T, Watanabe K, Liu X, Dmitrovsky E, Kage H, Kawakami M
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02776
[Presentation] Targeting KIFC1 to combat small cell lung cancer potentially through inhibition of supernumerary centrosome clustering2023
- Author(s)
  Nakagawa N, Tokunaga M, Iida T, Ka M, Ando T, Maemura K, Watanabe K, Kage H, Kawakami M
- Organizer
  The 82nd Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-21H02776
[Presentation] CDK2 Inhibition and Disruption of Centrosome Stoichiometry: A Clinically Tractable Death Program for Aneuploid Cancer Cells2023
- Author(s)
  Chen Z, Liu X, Kawakami M, Liu X, Baker A, Bhatawadekar A, Tyutyunyk-Massey L, Dmitrovsky E, Narayan K
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02776
[Presentation] Novel targets to treat lung cancer2021
- Author(s)
  Kawakami M
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22833
[Presentation] Novel targets to treat lung cancer2021
- Author(s)
  Kawakami M
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02776
[Presentation] Inducing Anaphase Catastrophe by CDK2 inhibitors to combat lung cancer2020
- Author(s)
  Kawakami M, Mustachio LM, Chen Y, Chen Z, Roszik J, Heymach JV, Kurie JM, Liu x, Dmitrovsky E
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K22833
[Presentation] Identification of FER as a new molecular target in non-small cell lung cancer2012
- Author(s)
  Masanori Kawakami
- Organizer
  24th EORTC-NCI-AACR Symposium 2012
- Place of Presentation
  Dublin, Ireland
- Data Source
  KAKENHI-PROJECT-24800019

1. 長瀬隆英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawakami Masanori 川上 正敬

KAWAKAMI Masanori 川上 正敬

Research Projects

Research Products

Co-Researchers

KIFC1を標的とした過剰中心体収束阻害による小細胞肺癌治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel therapeutic targets for cancer by inhibiting supernumerary centrosome clusteringPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting supernumerary centrosomes clustering by CDK2 inhibition to combat lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肺癌個別化医療実現へ向け過剰発現キナーゼ検出法確立とシグナル経路のプロテオミクスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肺癌で過剰発現するチロシンキナーゼと機能の総合的解析と臨床標本における検出法確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CDK2 Inhibition Produces a Persistent Population of Polyploid Cancer Cells.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TRIGGERING ANAPHASE CATASTROPHE TO COMBAT ANEUPLOID CANCERS2020

Author(s)

Journal Title

Data Source

[Journal Article] Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer2013

Author(s)

Journal Title

Data Source

[Presentation] CDK2 Inhibition Produces Persistent Polyploid Cancer Cells with a Survival Advantage2025

Author(s)

Organizer

Data Source

[Presentation] Prevention of centrosome clustering by targeting the motor protein X: A promising therapeutic strategy for small cell lung cancer.2025

Author(s)

Organizer

Data Source

[Presentation] KIFC1 inhibition elicits antineoplastic activity in small cell lung cancer by inducing anaphase catastrophe2024

Author(s)

Organizer

Data Source

[Presentation] Targeting KIFC1 to combat small cell lung cancer potentially through inhibition of supernumerary centrosome clustering2023

Author(s)

Organizer

Data Source

[Presentation] CDK2 Inhibition and Disruption of Centrosome Stoichiometry: A Clinically Tractable Death Program for Aneuploid Cancer Cells2023

Kawakami Masanori 川上正敬

KAWAKAMI Masanori 川上正敬