Futai Yujin 二井勇人

… Alternative Names

FUTAI Eugene 二井勇人

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Researcher Number	90447459
Other IDs
Affiliation (Current)	2026: 東北大学, 農学研究科, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 東北大学, 農学研究科, 准教授 2011 – 2015: 東北大学, (連合)農学研究科(研究院), 准教授 2009 – 2011: 東北大学, 大学院・農学研究科, 准教授 2009: The University of Tokyo, 大学院・農学研究科, 准教授 2007 – 2008: The University of Tokyo, 大学院・総合文化研究科, 助教
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 43030:Functional biochemistry-related / Science and Engineering Except Principal Investigator Applied molecular and cellular biology
Keywords	Principal Investigator 酵母 / 認知症 / 酵素 / アルツハイマー病 / 膜内切断プロテアーゼ / バイオテクノロジー / 応用微生物 / 神経科学 / 脳神経疾患 / 脳・神経 … More / プロテアーゼ / γセクレターゼ / アミロイドβ / 試験管内再構成 / リポソーム / COPII小胞 / 小胞輸送 / γ-セクレターゼ / 膜輸送と輸送蛋白質 … More Except Principal Investigator 天然物資源 / 薬剤探索 / αシヌクレイン / Gas7 / 生活習慣病 / キネシン / リン酸化タウ / 機能調節剤 / 微小管関連タンパク質 / 微小管重合 / JNK / Pin1 / CAMKII / パクリタクセル / motility assay / コンデショナルノックアウトマウス / hGas7b / 肥満 / CREB / Gas7b / Pn1 / プロリン異性化酵素 / 微小管 / アルツハイマー病 / タンパク質・糖鎖工学 / 発生・分化制御 / 細胞機能 Less

Structural basis for activation of intramembrane proteasesPrincipal Investigator
- Principal Investigator
  
  Futai Eugene
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tohoku University
Characterization of intramembrane proteases by yeast reconstitution systemPrincipal Investigator
- Principal Investigator
  
  Eugene Futai
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tohoku University
Characterization of intramembrane proteases by the yeast resonctitution systemPrincipal Investigator
- Principal Investigator
  
  Eugene Futai
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University
コート小胞形成における動的秩序形成メカニズムの解明Principal Investigator
- Principal Investigator
  
  二井勇人
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tohoku University
Molecular mechanism in regulation of the intramembrane proteasesPrincipal Investigator
- Principal Investigator
  
  FUTAI Eugene
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University
Drug Discovery of Alzheimer Disease from Molecules- Regulating Microtubule Polymerization
- Principal Investigator
  
  UCHIDA Takafumi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Tohoku University
COPII vesicle formation and the membrane trafficking in Alzheimer's disease.Principal Investigator
- Principal Investigator
  
  FUTAI Eugene
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo

[Book] 脳-分子・遺伝子・生理-2011
- Author(s)
  石浦章一, 笹川昇, 二井勇人
- Publisher
  裳華房
- Data Source
  KAKENHI-PROJECT-23657082
[Book] 脳21(膜結合型メタロプロテアーゼ(MMP、ADAM)ファミリー)13巻(No.1)2010
- Author(s)
  二井勇人、石浦章一
- Publisher
  金芳堂社
- Data Source
  KAKENHI-PROJECT-19770101
[Book] 生物の科学『遺伝』(家族性自閉症の遺伝子変異)61巻(No.3)2007
- Author(s)
  石浦章一、山川英訓、二井勇人
- Publisher
  裳華房社
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] C-terminal amino acids in the type I transmembrane domain of L-type lectin VIP36 affect γ-secretase susceptibility2024
- Author(s)
  Hua Zhihai、Watanabe Ryoma、Fukunaga Taku、Matsui Yojiro、Matsuoka Mayu、Yamaguchi Shoya、Tanabe Shun-ya、Yamamoto Miyu、Tamura-Kawakami Keiko、Takagi Junichi、Kajita Mihoko、Futai Eugene、Shirakabe Kyoko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 696 Pages: 149504-149504
- DOI
  10.1016/j.bbrc.2024.149504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06121, KAKENHI-PROJECT-21K07236
[Journal Article] A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site2023
- Author(s)
  Futai Eugene、Kawasaki Hajime、Sato Shinichi、Daoudi Khadija、Hidaka Masafumi、Tomita Taisuke、Ogawa Tomohisa
- Journal Title
  
  Toxins
  
  Volume: 15 Issue: 8 Pages: 500-500
- DOI
  10.3390/toxins15080500
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06121, KAKENHI-PROJECT-22K19097, KAKENHI-PROJECT-23H00394
[Journal Article] Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production2023
- Author(s)
  Suzuki Ryota、Takahashi Haruka、Yoshida Chika、Hidaka Masafumi、Ogawa Tomohisa、Futai Eugene
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 4 Pages: 3970-3970
- DOI
  10.3390/ijms24043970
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06121
[Journal Article] Specific Mutations in Aph1 Cause γ-Secretase Activation2022
- Author(s)
  Watanabe Hikari、Yoshida Chika、Hidaka Masafumi、Ogawa Tomohisa、Tomita Taisuke、Futai Eugene
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 507-507
- DOI
  10.3390/ijms23010507
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06558, KAKENHI-PROJECT-19H01015
[Journal Article] Focused Proteomics Analysis of Habu Snake (Protobothrops flavoviridis) Venom Using Antivenom-Based Affinity Chromatography Reveals Novel Myonecrosis-Enhancing Activity of Thrombin-Like Serine Proteases2021
- Author(s)
  Ogawa Tomohisa、Tobishima Yu、Kamata Shizuka、Matsuda Youhei、Muramoto Koji、Hidaka Masafumi、Futai Eugene、Kuraishi Takeshi、Yokota Shinichi、Ohno Motonori、Hattori Shosaku
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 12
- DOI
  10.3389/fphar.2021.766406
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06558
[Journal Article] Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation2020
- Author(s)
  Urano Yasuomi、Takahachi Mina、Higashiura Ryo、Fujiwara Hitomi、Funamoto Satoru、Imai So、Futai Eugene、Okuda Michiaki、Sugimoto Hachiro、Noguchi Noriko
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 2 Pages: 349-349
- DOI
  10.3390/cells9020349
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06558, KAKENHI-PROJECT-19K07093
[Journal Article] Advanced Yeast Models of Familial Alzheimer Disease Expressing FAD-Linked Presenilin to Screen Mutations and γ-Secretase Modulators2019
- Author(s)
  Futai Eugene
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2049 Pages: 403-417
- DOI
  10.1007/978-1-4939-9736-7_23
- ISBN
  9781493997350, 9781493997367
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06558
[Journal Article] Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming2018
- Author(s)
  Imai So、Cai Tetsuo、Yoshida Chika、Tomita Taisuke、Futai Eugene
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 165 Issue: 1 Pages: 37-46
- DOI
  10.1093/jb/mvy081
- NAID
  40021789427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-16K07290, KAKENHI-PROJECT-19K06558
[Journal Article] Functional properties of gamma-secretase in the yeast reconstitution system2016
- Author(s)
  二井勇人
- Journal Title
  
  生化学
  
  Volume: 88 Issue: 2 Pages: 215-219
- DOI
  10.14952/SEIKAGAKU.2016.880215
- NAID
  40020843388
- ISSN
  0037-1017
- Year and Date
  2016-04-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-16K07290
[Journal Article] Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities2016
- Author(s)
  Eugene Futai, Satoko Osawa, Tetsuo Cai, Tomoya Fujisawa, Shoichi Ishiura and Taisuke Tomita
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 1 Pages: 435-436
- DOI
  10.1074/jbc.m114.629287
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26102504, KAKENHI-PUBLICLY-26111705, KAKENHI-PROJECT-15H02492
[Journal Article] Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.2016
- Author(s)
  YOnemura, Y., Futai, E., Yagishita, S., Aether, C., and Ishiura, S.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 478 Issue: 4 Pages: 1751-1757
- DOI
  10.1016/j.bbrc.2016.09.018
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07290, KAKENHI-PROJECT-16K21328
[Journal Article] 酵母を用いたアルツハイマー病の病因研究2016
- Author(s)
  二井勇人
- Journal Title
  
  化学と生物
  
  Volume: 54 Pages: 530-532
- Data Source
  KAKENHI-PROJECT-16K07290
[Journal Article] Phosphatidylethanolamine plasmalogen enhances the inhibiting effect of phosphatidylethanolamine on γ-secretase activity2015
- Author(s)
  Tomoko Onodera, Eugene Futai, Eiichiro Kan, Naoki Abe, Takafumi Uchida, Yoshiyuki Kamio and Jun Kaneko
- Journal Title
  
  Journal of Biochemistry,156,(2015)]
  
  Volume: 156 Issue: 5 Pages: 301-309
- DOI
  10.1093/jb/mvu074
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26292043, KAKENHI-PROJECT-26660287, KAKENHI-PUBLICLY-26102504, KAKENHI-PROJECT-26252064
[Journal Article] CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.2012
- Author(s)
  Watahiki H, Yagishita S, Futai E, Ishiura S.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 526 Issue: 2 Pages: 96-99
- DOI
  10.1016/j.neulet.2012.08.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082, KAKENHI-PROJECT-23700429
[Journal Article] Localization of mature neprylysin in lipid rafts2012
- Author(s)
  Sato, K., Tanabe, C., Yoneyama, Y., Watahiki, H., Zhao, Y., Yagishita, S., Ebina, M., Suo, S., Futai, E., Murata, M. & Ishiura, S
- Journal Title
  
  J. Neurosci. Res
  
  Volume: 90 Pages: 870-877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082
[Journal Article] CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of A β -lowering γ-secretase modulators2012
- Author(s)
  Watahiki, H., Yagishita, S., Futai, E. & Ishiura, S
- Journal Title
  
  Neurosci. Lett
  
  Volume: 526 Pages: 96-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082
[Journal Article] Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by γ -secretase complex2012
- Author(s)
  Nagara, Y., Hagiyama, M., Hatano, N., Futai, E., Suo, S., Takaoka, Y., Murakami, Y., Ito, A. & Ishiura, S
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 417 Pages: 462-467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082
[Journal Article] Localization of mature neprilysin in lipid rafts.2012
- Author(s)
  Sato K, Tanabe C, Yonemura Y, Watahiki H, Zhao Y, Yagishita S, Ebina M, Suo S, Futai E, Murata M, Ishiura S.
- Journal Title
  
  J. Neurosci. Res.
  
  Volume: 90 Issue: 4 Pages: 870-877
- DOI
  10.1002/jnr.22796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082, KAKENHI-PROJECT-23700425, KAKENHI-PROJECT-23700429
[Journal Article] Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.2011
- Author(s)
  Yonemura, Y., Futai, E., Yagishita, S., Suo, S., Tomita, T., Iwatsubo, T. & Ishiura, S.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 44569-44575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082
[Journal Article] Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system2011
- Author(s)
  Yonemura, Y., Futai, E., Yagishita, S., Suo, S., Tomita, T., Iwatsubo, T. & Ishiura, S
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 44569-44575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657082
[Journal Article] beta-secretase inhibitor potency is decreased by aberrant beta-cleavage location of the "Swedish mutant" amyloid precursor protein.2010
- Author(s)
  Yamakawa, H., Yagishita, S., Futai, E., Ishiura, S.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 285 Pages: 1634-1642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] beta-secretase inhibi tor potency is decreased by aberrant bet a-cleavage location of the "Swedish mut ant" amyloid precursor protein.2010
- Author(s)
  Yamakawa, H., Yagishita, S., Futai, E., Ishiura, S.
- Journal Title
  
  J.BiolJ.Biol.Chem. Vol.285
  
  Pages: 1634-1642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Reduction of amyloid beta-peptide accumulation in Tg2576 transgenic mice by oral vaccination.2010
- Author(s)
  Ishii-Katsuno R., Nakajima, A., Katsuno, T., Nojima, J., Futai, E., Sasagawa, N., Yoshida, T., Watanabe, Y., Ishiura, S.
- Journal Title
  
  Biochem. Biophys. Res.Commun. Vol.399
  
  Pages: 593-599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Nicastrin is dispensable for γ secretase protease activity in the presence of specific presenilin mutations.2009
- Author(s)
  Futai, E., Yagishita, S., Ishiura, S.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 284 Pages: 13013-13022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Nicastrin is dispensable for γ-secretase protease activity in the presence of specific presenilin mutations2009
- Author(s)
  Futai, E., Yagishita, S., and Ishiura, S.
- Journal Title
  
  Journal of Biological Chemistry (advanced on line nublification)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Biochemical analysis of oligomerization of expanded polyalanine repeat proteins.2009
- Author(s)
  Nojima, J., Oma, Y., Futai, E., Sasagawa, N., Kuroda, R., Turk, B., Ishiura, S.
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 87 Pages: 2290-2296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Polyalanine tracts directly induce the release of cytochrome c, independently of the mitochondrial permeability pore, leading to apoptosis.2009
- Author(s)
  Toriumi, K., Oma, Y., Mimoto, A., Futai, E., Sasagawa, N., Turk, B., Ishiura, S.
- Journal Title
  
  Genes to Cells
  
  Volume: 14 Pages: 751-757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Nicastrin is dispensable for γ secretase protease activity in the presence of specific presenilin mutations.2009
- Author(s)
  Futai, E., Yagishita, S. Ishiura, S.
- Journal Title
  
  J.Biol.Chem. Vol.284
  
  Pages: 13013-13022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] 1,3-Capryloyl-2-arachidonoyl glycerol activates alpha-secretase activity and suppresses Abeta40 secretion in A172 cells.2008
- Author(s)
  Tanabe, C., Ebina, M., Asai, M., Futai, E., Sasagawa, N., Katano, K., Fukami, H., Ishiura, S.
- Journal Title
  
  Neuroscience Letter Vol.450
  
  Pages: 324-326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells.2008
- Author(s)
  Mitsuhashi H, Futai E, Sasagawa N, Hayashi Y, Nishino I, Ishiura S.
- Journal Title
  
  J.Neurochem. Vol.105
  
  Pages: 101-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Dysbindin-I, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner2008
- Author(s)
  Oyama, S., Yamakawa, H., Sasagawa, N., Hosoi, Y., Futai, E., and Ishiura S.
- Journal Title
  
  PLoS ONE 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Inhibition by KMI-574 leads to dislocalization of BACEI from lipid rafts2008
- Author(s)
  Ebina, M., Futai, E., Tanabe, C., Sasagawa, N., Kiso, Y., and Ishiura, S.
- Journal Title
  
  Journal of Neuroscience Research 87
  
  Pages: 360-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] In vitro reconstitution of γ-secretase activity using yeast microsomes.2008
- Author(s)
  Yagishita, S., Futai, E., Ishiura, S.
- Journal Title
  
  Biochem. Biophys. Res.Commun. Vol.377
  
  Pages: 141-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] 1, 3-Capryloyl-2-arachidonoyl glycerol activates alpha-secretase activity and suppresses Abeta40 secretion in A172 cells2008
- Author(s)
  Tanabe, C., Ebina, M., Asai, M., Futai, E., Sasagawa, N., Katano, K., Fukami, H., and Ishiura, S.
- Journal Title
  
  Neuroscience Letter 450
  
  Pages: 324-326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Expression of polyalanine stretches induces mitochondrial dysfunction2008
- Author(s)
  Toriumi, K., Oma, Y., Kino, Y., Futai, E., Sasagawa, N., and Ishiura, S.
- Journal Title
  
  Journal of Neuroscience Research 86
  
  Pages: 1529-1537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Inhibition by KMI-574 leads to dislocalization of BACE1 from lipid rafts.2008
- Author(s)
  Ebina, M., Futai, E., Tanabe, C., Sasagawa, N., Kiso, Y., Ishiura, S.
- Journal Title
  
  J.Neurosci. Res. Vol.87
  
  Pages: 360-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] In vitro reconstitution of γ-secretase activity using yeast microsomes2008
- Author(s)
  Yagishita, S., Futai, E., and Ishiura, S.
- Journal Title
  
  Biochem. Biophys. Res. Commun 377
  
  Pages: 141-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] MBNL1 associates with YB-1 in cytoplasmic stress granules2008
- Author(s)
  Onishi, H., Kino, Y., Morita, T., Futai, E., Sasagawa, N., and Ishiura, S.
- Journal Title
  
  Journal of Neuroscience Research 86
  
  Pages: 1994-2002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] MBNL1 associates with YB-1 in cytoplasmic stress granules.2008
- Author(s)
  Onishi H, Kino Y, Morita T, Futai E, Sasagawa N, Ishiura S.
- Journal Title
  
  Journal of Neuroscience Research Early View on line
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Expression of polyalanine stretches induces mitochondrial dysfunction.2008
- Author(s)
  Toriumi K, Oma Y, Kino Y, Futai E, Sasagawa N, Ishiura S.
- Journal Title
  
  Journal of Neuroscience Research Early View on line
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Journal Article] Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells.2008
- Author(s)
  Mitsuhashi H, Futai E, Sasagawa N, Hayashi Y, Nishino I, Ishiura S.
- Journal Title
  
  Journal of Neurochemistry 105
  
  Pages: 101-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770101
[Patent] アミロイドβを分解する酵素、及びこれを用いた医薬組成物2023
- Inventor(s)
  二井勇人、小川智久、川崎創、佐藤伸一、日高将文
- Industrial Property Rights Holder
  二井勇人、小川智久、川崎創、佐藤伸一、日高将文
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-190410
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-22K06121
[Patent] γセクレターゼ阻害剤、Aβペプチド産生抑制及び医薬2022
- Inventor(s)
  二井勇人、榊原里奈、関正義、日高将文、小川智久
- Industrial Property Rights Holder
  二井勇人、榊原里奈、関正義、日高将文、小川智久
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-106682
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] γセクレターゼ活性化変異体の発現・精製系構築および立体構造解析2025
- Author(s)
  井上大輝, 七谷圭, 日高將文, 小川智久, 二井勇人
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] ハブ由来３本指型毒素によるγセクレターゼ阻害の解析2024
- Author(s)
  推名美桜, 鈴木那知, 榊原里奈, 日高將文, 二井勇人, 小川智久
- Organizer
  第29回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] A Metalloprotease cocktail from the venom of Protobothrops flavoviridis cleaves amyloid beta peptides at the α-cleavage site.2023
- Author(s)
  Eugene Futai, Hajime Kawasaki, Shinichi Sato, Khadija Daoudi, Masafumi Hidaka, Taisuke Tomita, Tomohisa Ogawa
- Organizer
  東京大学医科学研究所奄美病害動物施設第３棟改築記念シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] γセクレターゼ活性化変異体の立体構造解析に向けた大量発現・精製系の構築2023
- Author(s)
  井上大輝, 日高將文, 小川智久, 二井勇人
- Organizer
  日本農芸化学会東北支部会第158回大会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] Habu snake three-finger toxins showed inhibitory activity against γ-secretase involved in amyloid β production causing Alzheimer disease2023
- Author(s)
  Tomohisa Ogawa, Rina Sakakibara, Masayoshi Seki, Masafumi Hidaka, Eugene Futai
- Organizer
  第60回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] C9orf72連鎖性筋萎縮性側索硬化症および前頭側頭型認知症におけるAUG非依存性翻訳機構解析系の構築2023
- Author(s)
  伊藤匠, 日高將文, 小川智久, 二井勇人
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] Specific presenilin mutation near the substrate binding site modulate γ-secretase activity2023
- Author(s)
  山口晶也, 鈴木涼太, 日高將文, 小川智久, 二井勇人
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] ハブ毒メタロプロテアーゼはアミロイドβを分解する2022
- Author(s)
  川崎創 , 日高将文 , 小川智久 , 二井勇人
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] C9orf72連鎖性筋萎縮性側索硬化症・前頭側頭型認知症におけるAUG非依存性翻訳解析系の構築2022
- Author(s)
  伊藤匠 , 日高將文 , 小川智久 , 二井勇人
- Organizer
  日本生化学会東北支部第８８回例会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] アミロイド前駆体タンパク質の切断感受性上昇変異の獲得とその解析2022
- Author(s)
  鈴木涼太 , 高橋春香 , 日高将文 , 小川智久 , 二井勇人
- Organizer
  第27回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] ハブベノミクス由来γセクレターゼ阻害ペプチドの同定と作用機構の解析2022
- Author(s)
  榊原里奈 , 関正義 , 日高将文 , 二井勇人 , 小川智久
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] γセクレターゼによる切断を調節するアミロイド前駆体タンパク質変異の同定2022
- Author(s)
  鈴木涼太 , 高橋春香 , 日高将文 , 小川智久 , 二井勇人
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06121
[Presentation] アミロイド前駆体タンパク質の切断感受性変異の獲得と解析2021
- Author(s)
  鈴木涼太, 高橋春香, 日高將文, 小川智久, 二井勇人
- Organizer
  日本農芸化学会東北支部第１５６回大会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] 酵母を用いたスクリーニングによるγセクレターぜサブユニットAph1の機能解析2021
- Author(s)
  渡辺ひかり, 吉田知加, 蔡哲夫, 日高將文, 小川智久, 富田泰輔, 二井勇人
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] γセクレターゼ変異体の解析に向けた酵母発現系・精製系の構築2021
- Author(s)
  関正義, 小川智久, 日高將文, 二井勇人
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] γセクレターゼによるアミロイド前駆体タンパク質の膜内切断感受性を変化させる配列要因の解析2021
- Author(s)
  鈴木涼太, 高橋春香，日高將文, 小川智久, 二井勇人
- Organizer
  日本生化学会東北支部第８７回例会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] ハブメタロプロテアーゼのアミロイドβに対する分解活性2021
- Author(s)
  川崎創，日高将文，小川智久，二井勇人
- Organizer
  第2６回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] γセクレターゼによる切断感受性を変化させるアミロイド前駆体タンパク質の配列要因2021
- Author(s)
  鈴木涼太, 高橋春香, 日高将文, 小川智久, 二井勇人
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] 出芽酵母ロンボイドPcp1pの生理機能解明と基質探索2021
- Author(s)
  角田俊揮, 日高將文, 小川智久, 新谷尚弘, 二井勇人
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] γセクレターゼ複合体構成因子Aph1による活性調節機構の解析2020
- Author(s)
  渡辺ひかり, 吉田知加, 蔡哲夫, 富田泰輔, 二井勇人
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] 出芽酵母ロンボイドPcp1pの生理機能解明と基質探索2020
- Author(s)
  角田俊揮, 日高將文, 小川智久, 新谷尚弘, 二井勇人
- Organizer
  日本農芸化学会東北支部第１５５回大会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] γセクレターゼ複合体構成因子Aph1による活性調節機構の解析2020
- Author(s)
  渡辺ひかり, 吉田知加, 蔡哲夫, 日高將文, 小川智久, 富田泰輔, 二井勇人
- Organizer
  日本農芸化学会東北支部第１５５回大会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] PS1変異体の解析によるγセクレターゼの構造変化とトリミング活性の上昇の解明2019
- Author(s)
  今井創、吉田知加、蔡哲夫、富田泰輔、二井勇人
- Organizer
  第38会日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] Presenilin 1活性化変異によるγセクレターゼのトリミング促進と構造変化の解明2019
- Author(s)
  二井勇人、今井創、吉田知加、蔡哲夫、富田泰輔
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06558
[Presentation] γセクレターゼ複合体構成因子Aph1による活性調節機構の解析2018
- Author(s)
  吉田知加、今井創、二井　勇人
- Organizer
  第23回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16K07290
[Presentation] γセクレターゼ複合体構成因子Aph1による活性調節機構の解析2018
- Author(s)
  吉田知加、高橋実希、今井創、二井勇人
- Organizer
  日本農芸化学会東北北海道合同支部会
- Data Source
  KAKENHI-PROJECT-16K07290
[Presentation] 膜内切断プロテアーゼによるタンパク質分解の制御機構の解明2017
- Author(s)
  二井勇人
- Organizer
  酵素研究助成第43回研究発表会
- Invited
- Data Source
  KAKENHI-PROJECT-16K07290
[Presentation] プレセニリン１の変異によるγセクレターゼ活性の変化と毒性Aβの減少2016
- Author(s)
  今井創、二井勇人
- Organizer
  第２１回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪府豊中市
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16K07290
[Presentation] プレセニリン１変異の解析によるγセクレターゼ活性制御機構へのアプローチ2016
- Author(s)
  今井創、二井勇人
- Organizer
  第３５回日本認知症学会学術集会
- Place of Presentation
  東京都千代田区
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K07290
[Presentation] プレセニリン１変異の解析によるγセクレターゼ活性制御機構へのアプローチ2016
- Author(s)
  今井創、二井勇人
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K07290
[Presentation] 酵母を用いたγセクレターゼの機能スクリーニングの有用性2016
- Author(s)
  二井勇人
- Organizer
  第２１回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪府豊中市
- Invited
- Data Source
  KAKENHI-PROJECT-16K07290
[Presentation] 家族性アルツハイマー病PS1変異の異常活性を回復させるサプレッサー変異の解析2015
- Author(s)
  二井勇人、大沢智子、蔡哲夫、石浦章一、富田太輔
- Organizer
  第20回病態プロテアーゼ学会
- Place of Presentation
  ANAクラウンプラザホテルグランコート名古屋（愛知県名古屋市）
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PUBLICLY-26102504
[Presentation] プロリン異性化酵素Pin1はPresenilin1に結合し、活性を制御する2013
- Author(s)
  佐々木広美、二井勇人、内田隆史
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台市、東北大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] プレセニリンとAph1分子の違いがγセクレターゼの機能に及ぼす影響2013
- Author(s)
  米村洋而、二井勇人、柳下聡介、石浦章一
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] プレセニリンとAph1 分子の違いがγセクレターゼの機能に及ぼす影響2013
- Author(s)
  米村洋而, 二井勇人, 柳下聡介, 石浦章一
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] プロリン異性化酵素Pin1の脳関連キナーゼCaMKIIへの影響2013
- Author(s)
  金井研太、小坂啓太、堤貴明、後藤愛那、二井勇人、日高將文、内田隆史
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台市, 東北大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] プロリン異性化酵素Pin1はPresenilin1に結合し、活性を制御する2013
- Author(s)
  佐々木広美、二井勇人、内田隆史
- Organizer
  2013年度日本農芸化学会大会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] プロリン異性化酵素Pin1 はPresenilin に結合し, 活性を制御する2013
- Author(s)
  佐々木広美, 二井勇人, 内田隆史
- Organizer
  2013年度日本農芸化学会大会
- Place of Presentation
  仙台
- Year and Date
  2013-03-25
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] 酵母再構成系を用いたγセクレターゼの機能解析2013
- Author(s)
  米村洋而, 二井勇人, 柳下聡介, 周防諭, 石浦章一
- Organizer
  第17回病態プロテアーゼ学会学術集会
- Place of Presentation
  浜松
- Year and Date
  2013-08-10
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] 酵母再構成系を用いたγセクレターゼの機能解析2013
- Author(s)
  米村洋而、二井勇人、柳下聡介、周防諭、石浦章一
- Organizer
  第17回病態プロテアーゼ学会学術集会
- Place of Presentation
  オークラアクトシティホテル浜松
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] アルツハイマー病関連タンパク質Gas7bの機能2013
- Author(s)
  乗田理恵、藤田彩子、後藤愛那、二井勇人、内田隆史
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台市、東北大学
- Data Source
  KAKENHI-PROJECT-20228006
[Presentation] エタノールアミン型リン脂質のγセクレターゼのin vitro 活性への影響2012
- Author(s)
  小野寺智子, 佐々木広美, 二井勇人, 内田隆史, 神尾好是, 金子淳
- Organizer
  2012年度日本農芸化学会大会
- Place of Presentation
  京都
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] 酵母再構成系によるγセクレターゼ活性の評価2012
- Author(s)
  米村洋而, 二井勇人, 柳下聡介, 周防諭, 石浦章一
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] 酵母再構成系によるγセクレターゼ活性の評価2012
- Author(s)
  米村洋而、二井勇人、柳下聡介、周防諭、石浦章一
- Organizer
  第３５回日本分子生物学会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] γセクレターゼによるAβ生成へのPin1 の作用機構解析2011
- Author(s)
  佐々木広美, 内田隆史, 二井勇人
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] 酵母再構成系によるγセクレターゼにおけるPS1とPS2 の比較2011
- Author(s)
  米村洋而, 二井勇人, 柳下聡介, 周防諭, 富田泰輔, 岩坪威, 石浦章一
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-23657082
[Presentation] 酵母γセクレターゼ再構成系を用いたpresenilin変異体の解析2010
- Author(s)
  二井勇人、柳下聡一、石浦章一
- Organizer
  酵母遺伝学フォーラム
- Place of Presentation
  ならまちセンター(奈良)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-19770101
[Presentation] アルツハイマー病治療を目指した○!Cセクレターゼ活性評価系の開発2009
- Author(s)
  二井勇人、柳下聡一、石浦章一
- Organizer
  第14回日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター(大阪)
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-19770101
[Presentation] 酵母でのγセクレターゼ再構成系を用いたpresenilin変異体の解析(Nicastrin is dispensable for gamma-secretase activity in the presence of specific presenilin mutations)2009
- Author(s)
  二井勇人、柳下聡一、石浦章一
- Organizer
  第82回日本生化学大会
- Place of Presentation
  神戸国際会議場(兵庫)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19770101
[Presentation] 酵母でのγセクレターゼ再構成系を用いたpresenilin変異体の解析2009
- Author(s)
  二井勇人
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19770101
[Presentation] Nicastrin is dispensable for protease activity of γ -secretase.2008
- Author(s)
  Futai, E., Yagishita, S., Ishiura, S.
- Organizer
  Society for Neuroscience 2008(北米神経科学会2008)
- Place of Presentation
  ワシントンD.C.(米国)
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19770101
[Presentation] Nicastrin is dispensable for protease activity of the γ-secretase2008
- Author(s)
  Futai, E., Yagishita, S., and Ishiura, S.
- Organizer
  Society for Neurosciece(北米神経科学会2008)
- Place of Presentation
  米国ワシントンD.C
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19770101
[Presentation] Recnstitution of γ-secretase activity using yeast microsome fraction.2008
- Author(s)
  Yagishita, S., Futai, E., Ishiura, S.
- Organizer
  Society for Neuroscience 2008(北米神経科学会2008)
- Place of Presentation
  ワシントンD.C.(米国)
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19770101
[Presentation] Sec16 inhibits GAP activity of COPII coat on synthetic liposomes.2007
- Author(s)
  Futai, E., Hamamoto, S., Schekman, R.
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-19770101
[Presentation] Sec16 inhibits GAP activity of the COPII coat on synthetic liposomes2007
- Author(s)
  Futai, E., Hamamoto, S., and Schek man, R.
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-19770101

1. UCHIDA Takafumi (80312239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. UCHIDA Chiyoko (80312776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. YAMASHITA Mari (50192430)

# of Collaborated Projects: 1 results

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4. HIROSE Keiko (90357872)

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5. OKUDA Toru (40328026)

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6. 日高將文 (00584848)

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7. Shintani Takahiro

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8. 富田泰輔

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9. 日高将文

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10. 神尾好是

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11. 金子淳

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Futai Yujin 二井 勇人

FUTAI Eugene 二井 勇人

Research Projects

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Structural basis for activation of intramembrane proteasesPrincipal Investigator

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Characterization of intramembrane proteases by yeast reconstitution systemPrincipal Investigator

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Characterization of intramembrane proteases by the yeast resonctitution systemPrincipal Investigator

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コート小胞形成における動的秩序形成メカニズムの解明Principal Investigator

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Molecular mechanism in regulation of the intramembrane proteasesPrincipal Investigator

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Drug Discovery of Alzheimer Disease from Molecules- Regulating Microtubule Polymerization

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COPII vesicle formation and the membrane trafficking in Alzheimer's disease.Principal Investigator

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[Book] 脳-分子・遺伝子・生理-2011

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[Book] 脳21(膜結合型メタロプロテアーゼ(MMP、ADAM)ファミリー)13巻(No.1)2010

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[Book] 生物の科学『遺伝』(家族性自閉症の遺伝子変異)61巻(No.3)2007

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[Journal Article] C-terminal amino acids in the type I transmembrane domain of L-type lectin VIP36 affect γ-secretase susceptibility2024

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[Journal Article] A Metalloproteinase Cocktail from the Venom of Protobothrops flavoviridis Cleaves Amyloid Beta Peptides at the α-Cleavage Site2023

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[Journal Article] Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production2023

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[Journal Article] Specific Mutations in Aph1 Cause γ-Secretase Activation2022

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[Journal Article] Focused Proteomics Analysis of Habu Snake (Protobothrops flavoviridis) Venom Using Antivenom-Based Affinity Chromatography Reveals Novel Myonecrosis-Enhancing Activity of Thrombin-Like Serine Proteases2021

Futai Yujin 二井勇人

FUTAI Eugene 二井勇人