Atarashi Ryuichiro 新竜一郎

… Alternative Names

新竜一郎アタラシリユウイチロウ

ATARASHI Ryuichiro 新竜一郎

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Researcher Number	90452846
Other IDs
External Links
Affiliation (Current)	2023: 宮崎大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023: 宮崎大学, 医学部, 教授 2015 – 2021: 宮崎大学, 医学部, 教授 2014 – 2015: 長崎大学, 医歯薬学総合研究科(医学系), 准教授 2014: 長崎大学, 医歯薬学総合研究科, 准教授 2012 – 2013: 長崎大学, 医歯(薬)学総合研究科, 准教授 … More 2010 – 2011: Nagasaki University, 大学院・医歯薬学総合研究科, 助教 2009: Nagasaki University, 医歯薬学総合研究科, 助教 2008: Nagasaki University, 大学院・医歯薬学総合研究科, 助教 Less
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Infectious disease medicine / Nerve anatomy/Neuropathology / Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Medium-sized Section 52:General internal medicine and related fields / Basic Section 52020:Neurology-related Except Principal Investigator Neurology / Infectious disease medicine
Keywords	Principal Investigator プリオン病 / 神経変性疾患 / プリオン / リコンビナントタンパク / 異常型PrP / 感染症診断学 / 異常型プリオンタンパク / 試験管内増幅法 / 早期診断 / 遺伝性プリオン病 … More / real-time QUIC法 / 髄液検査 / FK506 / 予防・治療法 / レビー小体型認知症 / alpha-synuclein / オリゴマー / アミロイドフィブリル / プリオン株 / PrP / タンパク単独仮説 / プリオンタンパク / RT-QuIC法 / PMCA法 / 孤発性クロイツフェルトヤコブ病 / クロイツフェルト・ヤコブ病 / 培養細胞 / RT-QUIC法 / クロイツフェルトヤコブ病 / 異常型プリオンタンパク質 / ロタウイルス / ネパール / 成人下痢症 / 種間伝播 / 系統樹解析 / 分子疫学 / 下痢症 / GPIアンカー / αシヌクレイン / プリオンタンパク質 / タウ蛋白 / TDP-43 … More Except Principal Investigator プリオン病 / 診断法 / 臨床症状 / 髄液検査 / クロイツフェルト・ヤコブ病 / ゲルストマン・ストロイスラー・シャインカー病 / 髄液 / クロイツフェルト・ヤコプ病(CJD) / パネルRT-QUIC法 / 孤発性CJD Less

抗プリオン薬のプリオン株特異的有効性と薬剤耐性機構の解明Principal Investigator
- Principal Investigator
  
  新竜一郎
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  University of Miyazaki
Does GPI-anchored modification promote the pathogenicity and transmissibility of alpha-synucleinopathies?Principal Investigator
- Principal Investigator
  
  新竜一郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  University of Miyazaki
Elucidation of rotavirus interspecies transmission mechanism in Nepal and the role of adults in rotavirus circulation.Principal Investigator
- Principal Investigator
  
  新竜一郎
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  University of Miyazaki
Elucidation of the amplification mechanism using cultured human prion persistent infection cells and development of novel prevention and treatment for prion diseasesPrincipal Investigator
- Principal Investigator
  
  Atarashi Ryuichiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  University of Miyazaki
The elucidation of molecular basis of the diversity and transmissibility in abnormal prion protein formationPrincipal Investigator
- Principal Investigator
  
  Atarashi Ryuichiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  University of Miyazaki
  Nagasaki University
Establishments of diagnosis for patients' CSF in humanprion disease and novel prion clinical research through field work
- Principal Investigator
  
  SATOH Katsuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagasaki University
Development of useful method in differential diagnosis of Creutzfeldt-Jakob diseases
- Principal Investigator
  
  MORI Tsuyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  University of Miyazaki
  Nagasaki University
Efficient seed-dependent alpha-synuclein aggregation in real-time quaking-induced conversion assayPrincipal Investigator
- Principal Investigator
  
  ATARASHI Ryuichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nagasaki University
Sensitive detection of abnormal prion protein in genetic human prion diseasesPrincipal Investigator
- Principal Investigator
  
  ATARASHI Ryuichiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nagasaki University
Sensitive prion detection by in vitro amplification of abnormal prion proteinPrincipal Investigator
- Principal Investigator
  
  ATARASHI Ryuichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagasaki University

All 2022 2021 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] プリオン病の髄液診断の可能性Annual Review神経2011
- Author(s)
  新竜一郎、佐藤克也
- Data Source
  KAKENHI-PROJECT-20390287
[Book] Annual Review神経「プリオン病の髄液診断の可能性」2011
- Author(s)
  新竜一郎、佐藤克也
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-23300127
[Journal Article] Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures.2022
- Author(s)
  Takatsuki H, Imamura M, Mori T, Atarashi R.
- Journal Title
  
  Scientific Reports
  
  Volume: － Pages: 7923-7923
- DOI
  10.1038/s41598-022-12049-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02721, KAKENHI-PROJECT-21K05938, KAKENHI-PROJECT-21K07277
[Journal Article] RT-QuIC as ultrasensitive method for prion detection.2022
- Author(s)
  Atarashi R.
- Journal Title
  
  Cell Tissue Res.
  
  Volume: －
- DOI
  10.1007/s00441-021-03568-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02721
[Journal Article] Spontaneous generation of distinct prion variants with recombinant prion protein from a baculovirus-insect cell expression system2022
- Author(s)
  Imamura M, Tabeta N, Iwamaru Y, Takatsuki H, Mori T, Atarashi R.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 613 Pages: 67-72
- DOI
  10.1016/j.bbrc.2022.04.137
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02721, KAKENHI-PROJECT-21K05938
[Journal Article] Development of radioiodinated acridine derivatives for in vivo imaging of prion deposits in the brain.2017
- Author(s)
  Kawasaki M, Fuchigami T, Kobashi N, Nakagaki T, Sano K, Atarashi R, Yoshida S, Haratake M, Nishida N, Nakayama M
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 25 Pages: 1085-1093
- DOI
  10.1016/j.bmc.2016.12.020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05392, KAKENHI-PROJECT-15K09895, KAKENHI-PROJECT-16K15585, KAKENHI-PROJECT-15KK0348, KAKENHI-PROJECT-15H04269
[Journal Article] Real-Time Quaking-Induced Conversion for Diagnosis of Prion Disease.2017
- Author(s)
  Satoh K, Atarashi R, Nishida N.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1658 Pages: 305-310
- DOI
  10.1007/978-1-4939-7244-9_21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04269
[Journal Article] A direct assessment of human prion adhered to steel wire using real-time quaking-induced conversion.2016
- Author(s)
  Mori T, Atarashi R, Furukawa K, Takatsuki H, Satoh K, Sano K, Nakagaki T, Ishibashi D, Ichimiya K, Hamada M, Nakayama T, Nishida N.
- Journal Title
  
  Scientific reports
  
  Volume: 6 Pages: 24993-24993
- DOI
  10.1038/srep24993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26461507, KAKENHI-PROJECT-16K07042
[Journal Article] プリオン病の脳脊髄液検査2016
- Author(s)
  佐藤克也, 新竜一郎, 西田教行
- Journal Title
  
  神経内科
  
  Volume: 84(3) Pages: 254-259
- Data Source
  KAKENHI-PROJECT-26305030
[Journal Article] The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases.2016
- Author(s)
  Schmitz M, Cramm M, Llorens F, Muller-Cramm D, Collins S, Atarashi R, Satoh K, Orru CD, Groveman BR, Zafar S, Schulz-Schaeffer WJ, Caughey B, Zerr I.
- Journal Title
  
  Nat Protoc
  
  Volume: 11 Pages: 2233-2242
- DOI
  10.1038/nprot.2016.120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-26305030
[Journal Article] Prion-seeding activity is widely distributed in tissues of sporadic Creutzfeldt-Jakob disease patients2016
- Author(s)
  Takatsuki H, Fuse T, Nakagaki T, Mori T, Mihara B, Takao M, Iwasaki Y, Yoshida M, Murayama S, Atarashi R, Nishida N, Satoh K.
- Journal Title
  
  EBioMedicine
  
  Volume: 12 Pages: 150-155
- DOI
  10.1016/j.ebiom.2016.08.033
- NAID
  120006987618
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-26461507, KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-16K18384
[Journal Article] Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt-jakob disease: An international study.2016
- Author(s)
  McGuire LI, Poleggi A, Poggiolini I, Suardi S, Grznarova K, Shi S, de Vil B, Sarros S, Satoh K, Cheng K, Cramm M, Fairfoul G, Schmitz M, Zerr I, Cras P, Equestre M, Tagliavini F, Atarashi R, Knox D, Collins S, Haik S, Parchi P, Pocchiari M, Green A.
- Journal Title
  
  Ann Neurol
  
  Volume: 未定 Pages: 160-165
- DOI
  10.1002/ana.24679
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-26305030
[Journal Article] Structure-based drug discovery for prion disease by using a novel binding simulation2016
- Author(s)
  Ishibashi D, Nakagaki T, Ishikawa T, Atarashi R, Watanabe K, Cruz FA, Hamada T, Nishida N.
- Journal Title
  
  EBioMedicine
  
  Volume: 9 Pages: 238-249
- DOI
  10.1016/j.ebiom.2016.06.010
- NAID
  120006987627
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-16K00397, KAKENHI-PROJECT-16K07042
[Journal Article] Prion-Seeding Activity Is widely Distributed in Tissues of Sporadic Creutzfeldt-Jakob Disease Patients.2016
- Author(s)
  Takatsuki H, Fuse T, Nakagaki T, Mori T, Mihara B, Takao M, Iwasaki Y, Yoshida M, Murayama S, Atarashi R, Nishida N, Satoh K.
- Journal Title
  
  EBioMedicine
  
  Volume: 12 Pages: 150-155
- NAID
  120006987618
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26305030
[Journal Article] Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells2015
- Author(s)
  Ishibashi D, Homma T, Nakagaki T, Fuse T, Sano K, Takatsuki H, Atarashi R, Nishida N.
- Journal Title
  
  PLoS One
  
  Volume: 10 Pages: 0137958-0137958
- DOI
  10.1371/journal.pone.0137958
- NAID
  120006986825
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-25461514, KAKENHI-PROJECT-26860671
[Journal Article] Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits2015
- Author(s)
  Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M.
- Journal Title
  
  Scientific reports
  
  Volume: 5 Pages: 18440-18440
- DOI
  10.1038/srep18440
- NAID
  120006987233
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09895, KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-25461514, KAKENHI-PROJECT-26860671
[Journal Article] Ubiquitin-specific protease 14 modulates degradation of cellular prion protein.2015
- Author(s)
  Homma T, Ishibashi D, Nakagaki T, Fuse T, Mori T, Satoh K, Atarashi R, Nishida N.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Pages: 11028-11028
- DOI
  10.1038/srep11028
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-26860671, KAKENHI-PROJECT-26305030
[Journal Article] Structural conservation of prion strain specificities in recombinant prion protein fibrils in real-time quaking-induced conversion2015
- Author(s)
  Sano K, Atarashi R, Nishida N.
- Journal Title
  
  Prion
  
  Volume: 9 Pages: 237-243
- DOI
  10.1080/19336896.2015.1062201
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-25461514
[Journal Article] Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases2015
- Author(s)
  Takatsuki H, Satoh K, Sano K, Fuse T, Nakagaki T, Mori T, Ishibashi D, Mihara B, Takao M, Iwasaki Y, Yoshida M, Atarashi R, Nishida N.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Pages: 0126930-0126930
- DOI
  10.1371/journal.pone.0126930
- NAID
  120006986998
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08369, KAKENHI-PROJECT-26430060, KAKENHI-PROJECT-15H04269, KAKENHI-PROJECT-25461514, KAKENHI-PROJECT-26860671, KAKENHI-PROJECT-26305030
[Journal Article] Conformational properties of prion strains can be transmitted to recombinant prion protein fibrils in real-time quaking-induced conversion2014
- Author(s)
  Sano K, Atarashi R, Ishibashi D, Nakagaki T, Satoh K, Nishida N.
- Journal Title
  
  Journal of virology
  
  Volume: 88(20) Pages: 11791-11801
- DOI
  10.1128/jvi.00585-14
- NAID
  120006986372
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24591268, KAKENHI-PROJECT-24591482, KAKENHI-PROJECT-25461514, KAKENHI-PROJECT-25640029, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26860671
[Journal Article] Persistent prion infection disturbs the function of Oct-1, resulting in the down-regulation of murine interferon regulatory factor-32014
- Author(s)
  Homma T, Ishibashi D, Nakagaki T, Fuse T, Sano K, Satoh K, Atarashi R, Nishida N.
- Journal Title
  
  SCIENTIFIC REPORTS
  
  Volume: 4 Pages: 6006-6006
- DOI
  10.1038/srep06006
- NAID
  120006986450
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24591268, KAKENHI-PROJECT-24591482, KAKENHI-PROJECT-25461514, KAKENHI-PROJECT-25640029, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26860671
[Journal Article] Increased expression of p62/SQSTM1 in prion diseases and its association with pathogenic prion protein.2014
- Author(s)
  Homma T, Ishibashi D, Nakagaki T, Satoh K, Sano K, Atarashi R, Nishida N.
- Journal Title
  
  Scientific reports
  
  Volume: 4 Pages: 4504-4504
- DOI
  10.1038/srep04504
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24591268, KAKENHI-PROJECT-24591482, KAKENHI-PROJECT-25461514, KAKENHI-PROJECT-26305030
[Journal Article] Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene.2014
- Author(s)
  Qina, T., N. Sanjo, M. Hizume, M. Higuma, M. Tomita, R. Atarashi, K. Satoh, I. Nozaki, T. Hamaguchi, Y. Nakamura, A. Kobayashi, T. Kitamoto, S. Murayama, H. Murai, M. Yamada and H. Mizusawa
- Journal Title
  
  BMJ Open.
  
  Volume: 4
- DOI
  10.1136/bmjopen-2014-004968
- NAID
  120006986552
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24591268, KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26670435
[Journal Article] Pressure-assisted dissociation and degradation of “proteinase K-resistant” fibrils prepared by seeding with scrapie-infected hamster prion protein2014
- Author(s)
  Akasaka K, Maeno A, Murayama T, Tachibana H, Fujita Y, Yamanaka H, Nishida N, Atarashi R.
- Journal Title
  
  Prion
  
  Volume: 8(4) Pages: 314-318
- DOI
  10.4161/pri.32081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-25450444, KAKENHI-PROJECT-25640029
[Journal Article] Age-dependent impairment of eyeblink conditioning in prion protein-deficient2013
- Author(s)
  Kishimoto Y, Hirono M, Atarashi R, Sakaguchi S, Yoshioka T, Katamine S, Kirino
- Journal Title
  
  PLOS ONE
  
  Volume: 8
- DOI
  10.1371/journal.pone.0060627
- NAID
  120006985917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24590068, KAKENHI-PROJECT-24590133
[Journal Article] FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice2013
- Author(s)
  Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R.
- Journal Title
  
  Autophagy
  
  Volume: 9 Pages: 1386-1394
- DOI
  10.4161/auto.25381
- NAID
  120006986076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24591482, KAKENHI-PROJECT-25461514
[Journal Article] Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay2013
- Author(s)
  Sano K, Satoh K, Atarashi R, Takashima H, Iwasaki Y, Yoshida M, Sanjo N, Murai
- Journal Title
  
  PLoS One
  
  Volume: 8(1)
- DOI
  10.1371/journal.pone.0054915
- NAID
  120006985758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-23790998
[Journal Article] Protective role of interferon regulatory factor3-mediated signaling against prion infection2012
- Author(s)
  Ishibashi D, Atarashi R, Fuse T, Nakagaki T, Yamaguchi N, Satoh K, Honda K, Nishida N
- Journal Title
  
  J Virol
  
  Volume: (Epub ahead of print)
- NAID
  120006985559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127
[Journal Article] Multicentre multiobserver study of diffusion-weighted and fluid-attenuated inversion recovery MRI for the diagnosis of sporadic Creutzfeldt-Jakob disease : a reliability and agreement study2012
- Author(s)
  Fujita K, Harada M, Sasaki M, Yuasa T, Sakai K, Hamaguchi T, Sanjo N, Shiga Y, Satoh K, Atarashi R, Shirabe S, Nagata K, Maeda T, Murayama S, Izumi Y, Kaji R, Yamada M, Mizusawa H
- Journal Title
  
  BMJ Open
  
  Volume: 2(1)
- NAID
  120006864094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127
[Journal Article] Protective role of MyD88-independent innate immune responses against prion infection.2012
- Author(s)
  Ishibashi D, Atarashi R, Nishida N
- Journal Title
  
  Prion.
  
  Volume: 6(5) Pages: 43-446
- DOI
  10.4161/pri.22579
- NAID
  120006985798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24591482
[Journal Article] Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors.2011
- Author(s)
  Kim JI, Cali I, Surewicz K, Kong Q, Raymond GJ, Atarashi R, (以下5名省略)
- Journal Title
  
  J Biol Chem
  
  Volume: 285(19) Pages: 14083-14087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.2011
- Author(s)
  Atarashi R, Satoh K, Sano, K, (以下14名省略)
- Journal Title
  
  Nature Medicine
  
  Volume: 17 Pages: 175-178
- NAID
  120006984771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Real-time quaking-induced conversion : A highly sensitive assay for prion detection2011
- Author(s)
  Atarashi R, Sano K, Satoh K, Nishida N
- Journal Title
  
  Prion
  
  Volume: 5(3) Pages: 150-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127
[Journal Article] High sensitivity of an ELISA kit for detection of the gamma-isoform of 14-3-3 proteins : usefulness in laboratory diagnosis of human prion disease2011
- Author(s)
  Matsui Y, Satoh K, Miyazaki T, Shirabe S, Atarashi R, Mutsukura K, Satoh A, Kataoka Y, Nishida N
- Journal Title
  
  BMC Neurol
  
  Volume: 11 Pages: 120-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300127
[Journal Article] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.2011
- Author(s)
  Atarashi R, Satoh K, Sano K
- Journal Title
  
  Nature Medicine 17
  
  Pages: 175-178
- NAID
  120006984771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.2010
- Author(s)
  Wilham JM, Orru CD, Bessen RA, Atarashi R, (以下6名省略)
- Journal Title
  
  PLoS Pathogens
  
  Volume: 6(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.2010
- Author(s)
  Wiham JM, Orru CD, Bessen RA, Atarashi R
- Journal Title
  
  PLoS Pathogens 6(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors.2010
- Author(s)
  Kim JI, Cali I, Surewicz K, Kong Q, Raymond GJ, Atarashi R
- Journal Title
  
  J Biol Chem 285(19)
  
  Pages: 14083-14087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Hyperefficient PrP Sc amplification of mouse-adapted BSE and scrapie strain by protein misfolding cyclic amplification technique.2009
- Author(s)
  Fujihara A, Atarashi R
- Journal Title
  
  FEBS J 276(10)
  
  Pages: 2841-2848
- NAID
  120006984475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Recent advances in cell-free PrPSc amplification technique.2009
- Author(s)
  Atarashi R
- Journal Title
  
  Protein&peptide letters 16(3)
  
  Pages: 256-259
- NAID
  120006982654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Distinct structures of scrapie prion protein(PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange.2009
- Author(s)
  Smirnovas V, Kim JI, Lu X, Atarashi R, Caughey B, Surewicz WK.
- Journal Title
  
  J Biol Chem. 284(36)
  
  Pages: 24233-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange.2009
- Author(s)
  Smirnovas V, Kim JI, Lu X, Atarashi R, Caughey B, Surewicz WK
- Journal Title
  
  J Biol Chem 284(36)
  
  Pages: 24233-24241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Hyperefficient PrP Sc amplification of mouse-adapted BSE and scrapie strain by protein misfolding cyclic amplification technique.2009
- Author(s)
  Fujihara A, Atarashi R, Fuse T, Ubagai K, Nakagaki T, Yamaguchi N, Ishibashi D, Katamine S, Nishida N.
- Journal Title
  
  FEBS J. 276(10)
  
  Pages: 2841-8
- NAID
  120006984475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking.2008
- Author(s)
  Atarashi R
- Journal Title
  
  Nature Methods 5(3)
  
  Pages: 211-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Journal Article] Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking.2008
- Author(s)
  Atarashi R, Wilham JM, Christensen L, Hughson AG, Moore RA, Johnson LM, Onwubiko HA, Priola SA, Caughey B.
- Journal Title
  
  Nature methods 5(3)
  
  Pages: 211-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] 異常型プリオンタンパク無細胞増幅法(RT-QUIC法とPMCA法)を駆使したプリオン病病態機構の解明.2021
- Author(s)
  新竜一郎
- Organizer
  第25回日本神経感染症学会総会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02721
[Presentation] Pentosan polysulfate induces latent prion infection in Fukuoka-1 strain-infected cells.2019
- Author(s)
  Takatsuki H, Mori T, Imamura M, Atarashi R
- Organizer
  Asian Pacific Prion Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02721
[Presentation] Isolation of hidden minor prion conformers from classical scrapie isolates in advanced protein misfolding cyclic amplification in the presence of arginine ethyl ester.2019
- Author(s)
  Imamura M, Miyazawa K, Matsuura Y, Iwamaru Y, Kitamoto T, Mohri S, Takatsuki H, Mori T, Atarashi R
- Organizer
  Asian Pacific Prion Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02721
[Presentation] さまざまなリコンビナントプリオン蛋白を基質としたRT-QUIC法の反応性の比較解析2019
- Author(s)
  森剛志, 今村守一, 高月英恵, 井口洋美, 大野美奈子, 新竜一郎
- Organizer
  日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-18H02721
[Presentation] バキュロウイルス-昆虫細胞発現組換えPrP を用いた試験管内変換系の構築に基づくプリオン変換・生成機構の解明.2017
- Author(s)
  新竜一郎,　今村守一,　森剛志,　高月英恵,　岩丸祥史
- Organizer
  日本薬学会第138年会(シンポジウム)
- Invited
- Data Source
  KAKENHI-PROJECT-15H04269
[Presentation] Spontaneously-generated baculovirus-derived abnormal recombinant prion protein has infectivity.2017
- Author(s)
  Imamura M, Tabeta N, Iwamaru Y, Yokoyama T, Murayama Y, Mori T, Takatsuki H, Atarashi R.
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04269
[Presentation] "Wire-QuIC": a new detection sysmte of human prion2016
- Author(s)
  Mori T, Atarashi R, Takatsuki H, Satoh K, Nakagaki T, Ishibashi D, Nishida N.
- Organizer
  Prion 2016
- Place of Presentation
  東京、日本
- Year and Date
  2016-05-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04269
[Presentation] Wire-QuIC reaction can detect abnormal human prion seeds from contaminated stainless steel-wire2016
- Author(s)
  Tsuyoshi Mori, Ryuichiro Atarashi, Katsuya Satoh, Daisuke Ishibashi, Takehiro Nakagaki, Noriyuki Nishida
- Organizer
  The 64th Annual Meeting of the Japanese Society for Virology
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-26461507
[Presentation] "Wire-QuIC": a new detection system of human prion2016
- Author(s)
  Tsuyoshi Mori, Ryuichiro Atarashi, Hanae Takatsuki, Katsuya Satoh, Takehiro Nakagaki, Daisuke Ishibashi, Noriyuki Nishida
- Organizer
  PRION 2016 TOKYO
- Place of Presentation
  Hitotsubashi Hall, National Center of Sciences Building
- Year and Date
  2016-05-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461507
[Presentation] Wire-QuIC reaction can detect abnormal human prion seeds from contaminated stainless steel-wire2016
- Author(s)
  Mori T, Atarashi R, Satoh K,Ishibashi D, Nakagaki T, Nishida N.
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌、日本
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15H04269
[Presentation] Analysis of biomarkers and RT-QUIC method of CSF in prion disease’ patients2015
- Author(s)
  Katsuya Satoh，Ryuichiro Atarashi，Hanae Takatuki，Tsuyoshi Mori，
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ (新潟コンベンションセンター)（新潟県）
- Year and Date
  2015-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26305030
[Presentation] Diagnostic evaluation of real-time quaking-induced conversion for the detection of human prion diseases.2015
- Author(s)
  Ryuichiro Atarashi
- Organizer
  Asian Pacific Prion Symposium 2015
- Place of Presentation
  石川県立音楽堂(石川県・金沢市）
- Year and Date
  2015-09-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04269
[Presentation] RT-QUIC法を用いたヒトプリオンサンプル中のSeeding Activityの測定2012
- Author(s)
  高月英恵、新竜一郎、佐野和憲、佐藤克也、西田教行
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23300127
[Presentation] Evaluation of RT-QUIC (real-time quaking-induced conversion) assay for genetic human prion diseases2011
- Author(s)
  新竜一郎
- Organizer
  Prion2011
- Place of Presentation
  カナダ(モントリオール)
- Year and Date
  2011-05-17
- Data Source
  KAKENHI-PROJECT-23300127
[Presentation] Evaluation of RT-QUIC (real-time quaking-induced conversion) assay for genetic human prion diseases2011
- Author(s)
  新竜一郎
- Organizer
  CJD 2011 and the Ninth Annual CJD Foundation Family Conference
- Place of Presentation
  アメリカ合衆国(ワシントンDC)
- Year and Date
  2011-07-08
- Data Source
  KAKENHI-PROJECT-23300127
[Presentation] Ultrasensitive human prion dectection in cerebrospinal fluids using real-time quaking-induced conversion.2010
- Author(s)
  新竜一郎
- Organizer
  Asia-Oceania Symposium on Prion diseases 2010
- Place of Presentation
  札幌
- Year and Date
  2010-07-25
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] シンポジウムI「プリオン病の疫学から治療まで」2010
- Author(s)
  新竜一郎
- Organizer
  第15回日本神経感染症学会
- Place of Presentation
  福島
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] Ultrasensitive human prion dectection in cerebrospinal fluids using real-time quaking-induced conversion.2010
- Author(s)
  新竜一郎
- Organizer
  Prion2010
- Place of Presentation
  オーストリア(ザルツブルグ)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.2010
- Author(s)
  新竜一郎
- Organizer
  Asia-Oceania Symposium on Prion diseases 2010
- Place of Presentation
  札幌
- Year and Date
  2010-07-05
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion.2010
- Author(s)
  新竜一郎
- Organizer
  Prion 2010
- Place of Presentation
  オーストリア(ザルツブルグ)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] Real-time QUIC法によるクロイツフェルトヤコブ病患者由来髄液中のPrp^<Sc>の検出2009
- Author(s)
  新竜一郎
- Organizer
  2009年プリオン研究会
- Place of Presentation
  宮城県刈田郡(ラフオーレ蔵王)
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] 正常型から異常型へのプリオンタンパク構造変換プロセスの解析2009
- Author(s)
  新竜一郎
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] Real-time QUIC(QUaking-Induced Conversion)によるクロイツフェルトヤコブ病患者由来髄液中のPrP^<Sc>の検出2009
- Author(s)
  新竜一郎
- Organizer
  2009年プリオン研究会
- Place of Presentation
  宮城県刈田郡
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] PMCA法によるマウスプリオン株の高効率の増幅2008
- Author(s)
  新竜一郎
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20390287
[Presentation] Clinical usefulness of the in vitro amplification of prion amyloid formation.
- Author(s)
  Atarashi R
- Organizer
  JSPS Japan Hungary Joint Seminar
- Place of Presentation
  大阪（大阪大学）
- Year and Date
  2014-11-18 – 2014-11-20
- Invited
- Data Source
  KAKENHI-PROJECT-23300127
[Presentation] Conformational properties of prion strains can be transmitted to recombinant prion protein fibrils in real-time quaking-induced conversion.
- Author(s)
  Sano K, Atarashi R, Nishida N
- Organizer
  Prion2014
- Place of Presentation
  Trieste, Italy
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-23300127
[Presentation] 異常型プリオンタンパク試験管内増幅法（Real-time QUIC法）によるプリオン株鑑別診断法の開発と分子機構の解明
- Author(s)
  新竜一郎, 祖母井香織, 福田茂夫，西田教行
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-23300127
[Presentation] プリオン蛋白の構造安定性に対する金属イオンの影響
- Author(s)
  祖母井香織, 新竜一郎, 西田教行
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23300127

1. SATOH Katsuya (70398147)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
2. MORI Tsuyoshi (40426565)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. 今村守一 (10391442)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. NISHIDA Noriyuki (40333520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
5. SANO Kazunori (50534343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. 岩丸祥史 (20355142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 岩下華子 (40742771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高月英恵 (80773978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. KISHIMOTO Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. ISHIBASHI Ishibashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
11. SATO Noriko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. KAWASAKI Masao

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. OBA Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. ISHIKAWA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. YAMANAKA Hitoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 桐野豊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 中垣岳大

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
18. 淵上剛志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 中山守雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 吉田さくら

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 小林和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 富田博秋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 富田泰輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 尾崎紀夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 村山繁雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 中村克樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 北本哲之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 西弘大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 鎌足雄司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 桑田一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 高尾昌樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 美原盤

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. 岩崎靖

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 赤坂一之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Atarashi Ryuichiro 新 竜一郎

新 竜一郎 アタラシ リユウイチロウ

ATARASHI Ryuichiro 新 竜一郎

Research Projects

Research Products

Co-Researchers

抗プリオン薬のプリオン株特異的有効性と薬剤耐性機構の解明Principal Investigator

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Does GPI-anchored modification promote the pathogenicity and transmissibility of alpha-synucleinopathies?Principal Investigator

Principal Investigator

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Elucidation of rotavirus interspecies transmission mechanism in Nepal and the role of adults in rotavirus circulation.Principal Investigator

Principal Investigator

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Review Section

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Elucidation of the amplification mechanism using cultured human prion persistent infection cells and development of novel prevention and treatment for prion diseasesPrincipal Investigator

Principal Investigator

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Review Section

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The elucidation of molecular basis of the diversity and transmissibility in abnormal prion protein formationPrincipal Investigator

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Establishments of diagnosis for patients' CSF in humanprion disease and novel prion clinical research through field work

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Development of useful method in differential diagnosis of Creutzfeldt-Jakob diseases

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Efficient seed-dependent alpha-synuclein aggregation in real-time quaking-induced conversion assayPrincipal Investigator

Principal Investigator

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Sensitive detection of abnormal prion protein in genetic human prion diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Sensitive prion detection by in vitro amplification of abnormal prion proteinPrincipal Investigator

Principal Investigator

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[Book] プリオン病の髄液診断の可能性Annual Review神経2011

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Data Source

[Book] Annual Review神経「プリオン病の髄液診断の可能性」2011

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Data Source

[Journal Article] Pentosan polysulfate induces low-level persistent prion infection keeping measurable seeding activity without PrP-res detection in Fukuoka-1 infected cell cultures.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RT-QuIC as ultrasensitive method for prion detection.2022

Author(s)

Atarashi Ryuichiro 新竜一郎

新竜一郎アタラシリユウイチロウ

ATARASHI Ryuichiro 新竜一郎