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Hasegawa Atsuhiko  長谷川 温彦

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HASEGAWA Atsuhiko  長谷川 温彦

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Researcher Number 90508334
Other IDs
Affiliation (Current) 2026: 東京科学大学, その他の部局等, 非常勤講師
2026: 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 臨床研究センター腫瘍病態研究部腫瘍細胞生物学研究室室長
Affiliation (based on the past Project Information) *help 2011 – 2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field
Principal Investigator
Hematology
Keywords
Principal Investigator
Tax特異的T細胞応答 / Tax特異的T細胞 / 免疫抑制 / HTLV-1特異的T細胞 / 成人T細胞白血病 / HTLV-1 / ATL / CTL / immunosuppression
  • Research Projects

    (1 results)
  • Research Products

    (40 results)
  •  HTLV-1-specific T cell suppression in infected individualsPrincipal Investigator

    • Principal Investigator
      HASEGAWA Atsuhiko
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University

All 2013 2012 2011

All Journal Article Presentation Patent

  • [Journal Article] Potential contribution of a novel Taxepitope-specific CD4+ T cells tograftversus-Tax effects in adult T-cell leukemia patients after allogeneichematopoietic stem celltransplantation.2013

    • Author(s)
      Tamai Y., Hasegawa A., Takamori A., et al.
    • Journal Title

      Journal of Immunology

      Volume: in press Issue: 8 Pages: 4382-4392

    • DOI

      10.4049/jimmunol.1202971

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-23591414, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-25461453, KAKENHI-PROJECT-221S0001
  • [Journal Article] Interferon-α(IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-αcombined with zidovudin induces p53 signaling and apoptosis in HTLV-1-infected cells2013

    • Author(s)
      Kinpara S, Kijiyama M, Takamori A, Hasegawa A, Sasada A, Masuda T, Tanaka Y, Utsunomiya A, Kannagi M
    • Journal Title

      Retrovirology

      Volume: 10 Issue: 1 Pages: 52-52

    • DOI

      10.1186/1742-4690-10-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591414, KAKENHI-PROJECT-221S0001
  • [Journal Article] The role of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases2012

    • Author(s)
      Mari Kannagi
    • Journal Title

      Frontiers in Microbiology

      Volume: 3 Pages: 1-10

    • DOI

      10.3389/fmicb.2012.00323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J00630, KAKENHI-PROJECT-23591414, KAKENHI-PROJECT-221S0001
  • [Journal Article] Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity2011

    • Author(s)
      Kannagi M, Hasegawa A, Kinpara S, Shimizu Y, Takamori A, Utsunomiya A
    • Journal Title

      Cancer Sci

      Volume: 102(4) Issue: 4 Pages: 670-6

    • DOI

      10.1111/j.1349-7006.2011.01862.x

    • NAID

      10029291668

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Journal Article] Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+cytotoxic T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers.2011

    • Author(s)
      Takamori A., Hasegawa A., Utsunomiya A., et al
    • Journal Title

      Retrovirology

      Volume: 8 Issue: 1 Pages: 100-100

    • DOI

      10.1186/1742-4690-8-100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-23591414, KAKENHI-PROJECT-221S0001
  • [Patent] HLA-DR1拘束性Tax特異的CD4+T細胞エピトープ2013

    • Inventor(s)
      玉井洋太郎,長谷川温彦,神奈木真理,田野崎隆二
    • Industrial Property Rights Holder
      玉井洋太郎,長谷川温彦,神奈木真理,田野崎隆二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-01-09
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Patent] HLA-DR1拘束性Tax特異的CD4+T細胞エピトープ2013

    • Inventor(s)
      玉井 洋太郎、長谷川 温彦、神奈木 真理、田野崎 隆二
    • Industrial Property Rights Holder
      玉井 洋太郎、長谷川 温彦、神奈木 真理、田野崎 隆二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-01-09
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Impact of innate and acquired immune responses in Adult T-cell Leukemia2013

    • Author(s)
      Kannagi M, Kinpara S, Takamori A, Sasada A, Hasegawa A
    • Organizer
      The 9^<th> AACR-Japanese cancer association joint conference
    • Place of Presentation
      Maui, HI
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] The phase-I study of a therapeutic vaccine to ATL patients with autologous dendritic cells pulsed with Tax peptides2013

    • Author(s)
      Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Tanosaki R, Utsunomiya A, Matsuoka M, Teshima T, Akashi K, Okamura J, Kannagi M, Uike N
    • Organizer
      第72回日本癌学会シンポジウム
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Unresponsiveness of Tax-specific CTLs in Rats Orally Infected with HTLV-1 and Reinduction of Functional Tax-specific CTLs by Peptide-pulsed BMDC Vaccine2013

    • Author(s)
      Hasegawa A
    • Organizer
      第4回日本血液学会(JSH)国際シンポジウム
    • Place of Presentation
      松山
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Kinetics of Tax-specific CTL in ATL patients following hematopoietic stem cell transplantation from uninfected donors2013

    • Author(s)
      Takamori A, Hasegawa A, Utsunomiya A, Choi I, Tanosaki R, Eto T, Kato K, Tamai Y, Sasada A, Suehiro Y, Uike N, Kannagi M
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Identification of novel HTLV-1-specific CD4 epitopes in ATL patients after hematopoietic stem cell transplantation2013

    • Author(s)
      Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Suehiro Y, Maeda Y, Yamano Y, Uike N, Kannagi M
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Unresponsiveness of Tax-specific CTLs in Rats Orally Infected with HTLV-1 and Reinduction of Functional Tax-specific CTLs by Peptide-pulsed BMDC Vaccine2013

    • Author(s)
      Hasegawa A
    • Organizer
      The 4th Japanese Society of Hematology, International Symposium
    • Place of Presentation
      大和屋本店、松山
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Peptide-pulsed dendritic cell vaccine reinduced functional Tax-specific CD8+ T cells in orally HTLV-1 infected rats with impaired Tax-specific CD8+ T cells responses2013

    • Author(s)
      Ando S, Hasegawa A, Murakami Y, Masuda T, Kannagi M.
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      幕張メッセ、千葉
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] ATL発症予防、治療を目的としたペプチドパルス樹状細胞療法に関する研究2013

    • Author(s)
      長谷川温彦、安藤聡美、高森絢子、玉井洋太郎、笹田亜麻子、神奈木真理
    • Organizer
      第23回日本樹状細胞研究会
    • Place of Presentation
      京都
    • Year and Date
      2013-05-17
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Augmentation of donor-derived Tax-specific CTL responses by a novel Tax epitope-specific CD4+ helper T-cells in ATL patients after allogeneic hematopoietic stem cell transplanation2013

    • Author(s)
      Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Etoh T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M.
    • Organizer
      The 16th International Conference on Human Retrovirology HTLV and Related Viruses
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Peptide-pulsed dendritic cell vaccine reinduced functional Tax-specific CD8+ T cells in orally HTLV-1 infected rats with impaired Tax-specific CD8+ T cells responses2013

    • Author(s)
      Ando S, Hasegawa A, Murakami Y, Masuda T, Kannagi M
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Immunological control of HTLV-1: Prospective therapy towards prophylaxis of disease2013

    • Author(s)
      Kannagi M. Hasegawa A, Suehiro Y, Takamori A, Kinpara S, Ando S, Utsunomiya A, Choi I, Uike N.
    • Organizer
      第6回HTLV-1研究会国際シンポジウム
    • Place of Presentation
      東京大学医科学研究所、東京
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Identification of a novel HLA-DR1-restricted dominant epitope recognized by HTLV-1 Tax-specific CD4+ T-cells augmenting HTLV-1-specific CTL expansion in ATL patients after allogeneic HSCT2013

    • Author(s)
      1. Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Etoh T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M.
    • Organizer
      The 9th AACR-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Hyatt Regency Maui (Maui, HI)
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] The phase-I study of a therapeutic vaccine to ATL patients with autologous dendritic cells pulsed with peptides corresponding to Tax-specific CTL epitopes2013

    • Author(s)
      Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Choi I, Fukuda T, Takaishi S, Tanosaki R, Utsunomiya A, Miura O, Matsuoka M, Teshima T, Akashi K, Okamura J, Kannagi M, Uike N
    • Organizer
      16th International Conference on Human Retrovirology HTLV and Related Viruses
    • Place of Presentation
      Montréal, Canada
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Identification of a novel HLA-DR1-restricted dominant epitope recognized by HTLV-1 Tax-specific CD4^+ T-cells augmenting HTLV-1-specific CTL expansion in ATL patients after allogeneic HSCT2013

    • Author(s)
      Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Etoh T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M
    • Organizer
      The 9^<th> AACR-Japanese cancer association joint conference
    • Place of Presentation
      Maui, HI
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Augmentation of donor-derived Tax-specific CTL responses by a novel Tax epitope-specific CD4+ helper T-cells in ATL patients after allogeneic hematopoietic stem cell transplanation2013

    • Author(s)
      Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Etoh T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M
    • Organizer
      16th International Conference on Human Retrovirology HTLV and Related Viruses
    • Place of Presentation
      Montréal, Canada
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Identification of novel HTLV-1-specific CD4 epitopes in ATL patients after hematopoietic stem cell transplantation2013

    • Author(s)
      Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Suehiro Y, Maeda Y, Yamano Y, Uike N, Kannagi M.
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] ATL発症予防、治療を目的としたペプチドパルス樹状細胞療法に関する研究2013

    • Author(s)
      長谷川温彦、安藤聡美、高森絢子、玉井洋太郎、笹田亜麻子、神奈木真理.
    • Organizer
      第23回日本樹状細胞研究会
    • Place of Presentation
      国立京都国際会館、京都
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] HTLV-1感染者におけるTax特異的T細胞応答およびATL発症予防2012

    • Author(s)
      10. 長谷川 温彦、高森 絢子、宇都宮 與、前田 裕弘、山野 嘉久、増田 昌人、清水 由紀子、玉井 洋太郎、笹田 亜麻子、崔 日承、鵜池 直邦、岡村 純、渡邉 俊樹、神奈木 真理.
    • Organizer
      第1回 ATLシンポジウム(第5回 HTLV-1研究会/シンポジウム)
    • Place of Presentation
      東京大学医科学研究所講堂(東京)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Functional impairment of CD8+ cytotoxic T lymphocytes selective for HTLV-1-specific responses in early stages of adult T-cell leukemia patients2012

    • Author(s)
      Takamori A, Hasegawa A, Utsunomiya A, Maeda Y, Yamano Y, Masuda M, Tamai Y, Sasada A, Choi I, Uike N, Okamura J, Watanabe T, Kannagi M
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Unresponsiveness of dominant Tax-specific CD8+ T cells in rats orally infected with HTLV-12012

    • Author(s)
      Ando S, Murakami Y, Hasegawa A, Masuda T, Kannagi M
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] HTLV-1経口感染ラットを用いたペプチドパルス樹状細胞ワクチン評価系作成のための基礎的研究2012

    • Author(s)
      安藤聡美、村上悠二、長谷川温彦、増田貴夫、神奈木真理
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] A novel HLA-DR-restricted epitope recognized by Tax-specific CD4+ T cells in ATL patients after allo-HSCT2012

    • Author(s)
      8. Tamai Y, Hasegawa A, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Etoh T, Koh KR, Suehiro Y, Okamura J, Uike N, Kannagi M.
    • Organizer
      第71回 日本癌学会学術総会
    • Place of Presentation
      札幌教育文化会館(札幌)
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] HTLV-1感染者におけるTax特異的T細胞応答およびATL発症予防2012

    • Author(s)
      長谷川温彦、高森絢子、宇都宮與、前田裕弘、山野嘉久、増田昌人、清水由紀子、玉井洋太郎、笹田亜麻子、崔日承、鵜池直邦、岡村純、渡邉俊樹、神奈木真理
    • Organizer
      第1回ATLシンポジウム(第5回HTLV-1研究会/シンポジウム)
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] A novel HLA-DR-restricted epitope recognized by Tax-specific CD4+ T cells in ATL patients after allo-HSCT2012

    • Author(s)
      Tamai Y, Hasegawa A, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Etoh T, Koh KR, Suehiro Y, Okamura J, Uike N, Kannagi M
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Functional impairment of Tax-specific but not CMV-specific CTLs in a minor population of asymptomatic carriers2011

    • Author(s)
      Hasegawa A, Takamori A, Utsunomiya A, Maeda Y, Yamano Y, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M
    • Organizer
      The 15^<th> International Conference on Human Retrovirology : HTLV and Related Viruses
    • Place of Presentation
      Leuven, Belgium
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] The evaluation of peptide-pulsed dendritic cell vaccine in HTLV-1-infected rats with weak T cell responses against HTLV-12011

    • Author(s)
      Zeng N, Hasegawa A, Shimizu Y, Tamai Y, Takamori A, Sasada A, Kannagi M
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Functional impairment of Tax-specific but not CMV-specific CTLs in a minor population of asymptomatic carriers2011

    • Author(s)
      Takamori A, Hasegawa A, Utsunomiya A, Maeda Y, Yamano Y, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Functional impairment of Tax-specific but not CMV-specific CD8+ T cells in a minor population of asymptomatic carriers2011

    • Author(s)
      Hasegawa A, Takamori A, Utsunomiya A, Maeda Y, Yamano Y, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M
    • Organizer
      The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic HTLV-1-carriers2011

    • Author(s)
      Atsuhiko Hasegawa
    • Organizer
      The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
    • Place of Presentation
      東京大学(東京)
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Evaluation of peptide-pulsed dendritic cell vaccine using HTLV-1-infected rat model2011

    • Author(s)
      Hasegawa A, Zeng N, Masuda T, Kannagi M
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] Functional impairment of Tax-specific but not CMV-specific CD8+ T cells in a minor population of asymptomatic carriers2011

    • Author(s)
      Takamori A, Hasegawa A, Utsunomiya A, Maeda Y, Yamano Y, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] 成人T細胞白血病リンパ腫(ATLL)に対する樹状細胞免疫療法に向けた、基礎解析と第I相臨床試験コールドラン2011

    • Author(s)
      笹田亜麻子、長谷川温彦、清水由紀子、末廣陽子、鵜池直邦、豊嶋崇徳、谷憲三朗、森尾友宏、福田哲也、三浦修、宇都宮與、神奈木真理
    • Organizer
      第3回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      別府
    • Data Source
      KAKENHI-PROJECT-23591414
  • [Presentation] The role of innate and acquired immune responses on HTLV-1 infection2011

    • Author(s)
      Kannagi M, Kinpara S, Hasegawa A, Takamori A, Shimizu Y, Utsunomiya A
    • Organizer
      The 15^<th> International Conference on Human Retrovirology : HTLV and Related Viruses
    • Place of Presentation
      Leuven, Belgium
    • Data Source
      KAKENHI-PROJECT-23591414

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