hayashi hideki 林秀樹

… Alternative Names

HAYASHI Hodeki 林秀樹

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Researcher Number	90508657
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 東京薬科大学, 薬学部, 准教授 2019 – 2020: 東京薬科大学, 薬学部, 准教授 2013 – 2018: 東京薬科大学, 薬学部, 講師 2012: 熊本大学, 大学院先導機構, 特定事業教員(特任助教) 2008 – 2011: Kumamoto University, 大学院・先導機構, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / General pharmacology / Ophthalmology
Keywords	Principal Investigator 緑内障 / LRP1 / 神経保護 / 抗体 / ナノバブル / アルファ２マクログロブリン / リポタンパク質 / グルタミン酸 / グリア細胞 / 脂質 … More / 神経科学 / リポプロテイン / 視神経変性 / リポタンパク質受容体 / 神経保護、 / アポリポタンパク質E含有リポタンパク質 / 神経変性 / リポタンパク / リポ蛋白 / 糖尿病 / 眼疾患 / 神経細胞 Less

抗LRP1抗体の超音波ナノバブル・イオン液体併用網膜薬物送達による緑内障治療戦略Principal Investigator
- Principal Investigator
  
  林秀樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of a non-invasive glaucoma treatment using ultrasonic nanobubbles associated with anti-LRP1 antibodyPrincipal Investigator
- Principal Investigator
  
  林秀樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
The neuroprotective mechanism of lipoproteins for optic nerve degeneration.Principal Investigator
- Principal Investigator
  
  Hideki Hayashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
A study on neuroprotection by glia-derived lipoproteins against nerve injuryPrincipal Investigator
- Principal Investigator
  
  Hayashi Hideki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo University of Pharmacy and Life Science
Neuroprotection via lipoprotein receptors against optic neuropathyPrincipal Investigator
- Principal Investigator
  
  HIDEKI Hayashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo University of Pharmacy and Life Science
  Kumamoto University
A potential treatment of glaucoma by glia-derived lipoproteins.Principal Investigator
- Principal Investigator
  
  HAYASHI Hideki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
Roles and possible treatment of lipoproteins in diabetic retinopathyPrincipal Investigator
- Principal Investigator
  
  HAYASHI Hodeki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Ophthalmology
- Research Institution
  Kumamoto University

[Book] Neuroprotection and neurodegeneration for retinal diseases2014
- Author(s)
  H. Hayashi, edited by T. Nakazawa, Y. Kitaoka, and T. Harada
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-24500441
[Book] Oxford University Press, Lipids, lipid mediators and other signaling molecules. Neuroglia, 3rd Edition2012
- Author(s)
  Hayashi H
- Data Source
  KAKENHI-PROJECT-22790254
[Book] Neuroglia Third Edition2012
- Author(s)
  Kettenmann H., Ransom B.R., Hayashi H. (Chapter 23)
- Publisher
  Oxford University Press
- Data Source
  KAKENHI-PROJECT-24500441
[Journal Article] Effects of laminin-111 peptide coatings on rat neural stem/progenitor cell culture.2021
- Author(s)
  Hayashi H, Horinokita I, Yamada Y, Hamada K, Takagi N, Nomizu M.
- Journal Title
  
  Experimental Cell Research
  
  Volume: 400 Issue: 1 Pages: 112440-112440
- DOI
  10.1016/j.yexcr.2020.112440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07376
[Journal Article] Investigating the Relationship Between Neuronal Cell Death and Early DNA Methylation After Ischemic Injury.2020
- Author(s)
  Asada M, Hayashi H, Murakami K, Kikuiri K, Kaneko R, Yuan B, Takagi N.
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 14 Pages: 581915-581915
- DOI
  10.3389/fnins.2020.581915
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07376
[Journal Article] Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA2019
- Author(s)
  Yamada Mariko、Hayashi Hideki、Suzuki Kaori、Sato Shoko、Inoue Daisuke、Iwatani Yui、Ohata Meiko、Yuan Bo、Takagi Norio
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 11782-11782
- DOI
  10.1038/s41598-019-48279-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07376, KAKENHI-PROJECT-17K08289
[Journal Article] Potential neuroprotective effects of an LSD1 inhibitor in retinal ganglion cells via p38 MAPK-gamma activity2016
- Author(s)
  T. Tsutsumi, K. Iwao, H. Hayashi, T. Kawaji, T. Inoue, S. Hino, M. Nakao, and H. Tanihara.
- Journal Title
  
  Invest. Ophthalmol. Vis. Sci.
  
  Volume: 57 Issue: 14 Pages: 6461-6473
- DOI
  10.1167/iovs.16-19494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04707, KAKENHI-PROJECT-26293375, KAKENHI-PROJECT-16K11290, KAKENHI-PROJECT-26462693, KAKENHI-PROJECT-15K15068, KAKENHI-PROJECT-15K06781, KAKENHI-PROJECT-16K07215
[Journal Article] Effects of Active Bufadienolide Compounds on Human Cancer Cells and CD4+CD25+Foxp3+ Regulatory T Cells in Mitogen-activated Human Peripheral Blood Mononuclear Cells.2016
- Author(s)
  Yuan B., He J., Kisoh K., Hayashi H., Tanaka S., Si N., Zhao H., Hirano T., Bian B. and Takagi N.
- Journal Title
  
  Oncology Rep
  
  Volume: 36 Issue: 3 Pages: 1377-1384
- DOI
  10.3892/or.2016.4946
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06781
[Journal Article] Involvement of GSK-3β Phosphorylation Through PI3-K/Akt in Cerebral Ischemia-Induced Neurogenesis in Rats.2016
- Author(s)
  Kisoh K., Hayashi H., Itoh T., Asada M, Arai M., Yuan B, Tanonaka K., and Takagi N.
- Journal Title
  
  Mol Neurobiol
  
  Volume: - Issue: 10 Pages: 7917-7927
- DOI
  10.1007/s12035-016-0290-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06781
[Journal Article] Endogenous Neuroprotective Molecules and Their Mechanisms in the Central Nervous System2015
- Author(s)
  Hayashi H. and Takagi N.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 8 Pages: 1104-1108
- DOI
  10.1248/bpb.b15-00361
- NAID
  130005090640
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06781
[Journal Article] Increasing Cellular Level of Phosphatidic Acid Enhances FGF-1 Production in Long Term-cultured Rat Astrocytes2014
- Author(s)
  Yuko Nagayasu, Shin-ya Morita, Hideki Hayashi, Yutaka Miura, Kazuki Yokoyama, Makoto Michikawa, Jin-ichi Ito
- Journal Title
  
  Brain Research
  
  Volume: 1563 Pages: 31-40
- DOI
  10.1016/j.brainres.2014.03.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500441, KAKENHI-PROJECT-25461375
[Journal Article] Enhancement of FGF-1 release along with cytosolic proteins from rat astrocytes by hydrogen peroxide.2013
- Author(s)
  Ito, J., Nagayasu, Y., Hoshikawa, M., Kato, K.H., Miura, Y., Asai, K., Hayashi, H., Yokoyama, S., and Michikawa, M
- Journal Title
  
  Brain Res
  
  Volume: 1522 Pages: 12-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500441
[Journal Article] A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma2012
- Author(s)
  Hayashi H, Eguchi Y, Fukuchi-Nakaishi Y, Takeya M, Nakagata N, Tanaka K, Vance JE, Tanihara H
- Journal Title
  
  J Biol Chem
  
  Volume: 287(30) Issue: 30 Pages: 25395-406
- DOI
  10.1074/jbc.m112.370130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390403, KAKENHI-PROJECT-23659814, KAKENHI-PROJECT-24500441
[Journal Article] Dynamic imaging of axonal transport in living retinal ganglion cells in vitro2011
- Author(s)
  Takihara, Y., Inatani, M., Hayashi, H., Adachi, N., Iwao, K., Inoue, T., Iwao, M., and Tanihara, H.
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 52 Pages: 3039-3045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790254
[Journal Article] Lipid metabolism and glial lipoproteins in the central nervous system2011
- Author(s)
  Hayashi, H.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 34 Pages: 453-461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790254
[Journal Article] 中枢神経系の脂質代謝と神経変性疾患2011
- Author(s)
  林秀樹
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 137 Pages: 227-231
- NAID
  10029417699
- Data Source
  KAKENHI-PROJECT-22790254
[Journal Article] Formation and function of apolipoprotein E-containing lipoproteins in the nervous system2010
- Author(s)
  Vance JE, Hayashi H
- Journal Title
  
  Biochimica et Biophysica Acta (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890174
[Journal Article] Formation and function of apolipoprotein E-containing lipoproteins in the nervous system2010
- Author(s)
  Vance, J. E., and Hayashi, H.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1801 Pages: 806-818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790254
[Journal Article] Vance JE Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cγ1 and inhibition of calcineurin2009
- Author(s)
  Hayashi H, Campenot RB, Vance DE
- Journal Title
  
  The Journal of Biological Chemistry 284
  
  Pages: 29605-29613
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890174
[Journal Article] Protection of neurons from apoptosis by apolipoprotein E-contaning lipoproetins does not require lipoprotein uptake and involes activation of phospholipase Cγ1 and inhibition of calcineurin2009
- Author(s)
  Hayashi H, Campenot RB, Vance DE, Vance JE
- Journal Title
  
  The Journal of Biological Chemistry 284
  
  Pages: 29605-29613
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890174
[Patent] リポ蛋白を用いたα２－マクログロブリンの神経保護抑制効果抑止剤及び眼科用組成物2014
- Inventor(s)
  林　秀樹
- Industrial Property Rights Holder
  林　秀樹
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-534722
- Filing Date
  2014-03-18
- Data Source
  KAKENHI-PROJECT-24500441
[Patent] リポ蛋白を用いた神経疾患予防・治療剤ならびに神経疾患予防・治療方法2012
- Inventor(s)
  林　秀樹
- Industrial Property Rights Holder
  熊本大学、東京医科歯科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-09-19
- Overseas
- Data Source
  KAKENHI-PROJECT-24500441
[Patent] リポ蛋白含有複合体およびリポ蛋白を用いた神経変性抑制剤ならびに神経変性抑制方法2011
- Inventor(s)
  林秀樹
- Industrial Property Rights Holder
  熊本大学、東京医科歯科大学
- Industrial Property Number
  2011-205390
- Filing Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-22790254
[Presentation] 網膜グリア細胞のリポタンパク質受容体LRP1を介したα2-マクログロブリン発現抑制による視神経保護機構2023
- Author(s)
  林　秀樹、森　みすず、見世　加南子、高木　教夫
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-23K24220
[Presentation] 染色体工学技術の抗体研究への応用（６）CDR-H3を標的としたゲノム編集誘導性分子多様化によるMammalian displayシステムの構築2023
- Author(s)
  櫻井　諒一、円子　大夢、橋本　七海、宇野　愛海、林　秀樹、香月　康弘、堀田　秋津、冨塚　一磨
- Organizer
  第2回日本抗体学会　20231201　鹿児島
- Data Source
  KAKENHI-PROJECT-23K24220
[Presentation] 抗体重鎖相補性決定領域3を標的とした相同組換えによる新規抗体ディスプレイの開発2023
- Author(s)
  櫻井　諒一、円子　大夢、橋本　七海、宇野　愛海、林　秀樹、香月　康弘、堀田　秋津、冨塚　一磨
- Organizer
  日本ゲノム編集学会第8回大会20230606　東京
- Data Source
  KAKENHI-PROJECT-23K24220
[Presentation] アポE含有リポタンパク質によるLRP1を介した網膜グリア細胞のα２-マクログロブリン発現抑制とNMDA誘発興奮毒性に対する網膜神経節細胞保護効果2022
- Author(s)
  林　秀樹、森　みすず、南　厚徳、見世　加南子、高木　教夫
- Organizer
  第96回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24220
[Presentation] 染色体工学技術の抗体研究への応用（9）相補性決定領域を標的としたアミノ酸挿入型・置換型ゲノム編集による新規抗体の探索2022
- Author(s)
  櫻井　諒一、円子　大夢、橋本　七海、宇野　愛海、林　秀樹、香月　康弘、堀田　秋津、冨塚　一磨
- Organizer
  第1回　日本抗体学会
- Data Source
  KAKENHI-PROJECT-23K24220
[Presentation] 虚血性神経障害における DNA メチル化の役割2021
- Author(s)
  浅田　眞由美、林　秀樹、村上健二郎、菊入健斗、金子遼太郎、袁博、高木　教夫
- Organizer
  第94回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] リポタンパク質受容体LRP1シグナルによる視神経保護2020
- Author(s)
  林秀樹、高木教夫
- Organizer
  第63回　日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] グリア細胞由来リポタンパク質のLRP1を介した神経保護と緑内障治療への応用2020
- Author(s)
  林秀樹、高木教夫
- Organizer
  第93回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] アポE含有リポタンパク質による初代培養網膜グリア細胞のα2マクログロブリン発現調節機構の解析2019
- Author(s)
  竹村映美、林秀樹、向垣内千早、袁博、高木教夫
- Organizer
  第140回　日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] Neuroprotective roles of apolipoprotein E containing lipoproteins in neurons and glia of retina2019
- Author(s)
  H. Hayashi, M. Mori, M. Yamada, B. Yuan, N. Takagi
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] 網膜のリポタンパク質受容体LRP1と視神経生存2019
- Author(s)
  林秀樹、森　みすず、原嶋美奈、橋爪達哉、向垣内千早、山田まりこ、袁博、高木教夫
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] 虚血性脳神経障害時のLRP1プロセシングと神経細胞死の関連2019
- Author(s)
  今村唯、堀之北一朗、林秀樹、高木教夫
- Organizer
  第140回　日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] ラット緑内障モデルの網膜α2マクログロブリンおよびアポE含有リポタンパク質の変化と視神経保護に関する研究2018
- Author(s)
  向垣内　千早、小島　拓也、林　秀樹、小林　美緒、小出　暉、袁　博、高木　教夫
- Organizer
  第１３８回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Protective effects of apolipoprotein E-containing lipoproteins against glaucomatous optic neuropathy2018
- Author(s)
  Hideki Hayashi, Mariko Yamada, Misuzu Mori, Mio Kobayashi, Hikaru Koide, Takuya Kojima, Chihaya Mukaigaito, Bo Yuan, Norio Takagi
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] ラット緑内障モデルに対するアポE含有リポタンパク質の視神経保護因子としての働き2018
- Author(s)
  林　秀樹、森みすず、袁　博、高木　教夫
- Organizer
  第１３８回日本薬学会
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Roles of low density lipoprotein receptor-related protein 1 ligands in glaucomatous optic neuropathy2018
- Author(s)
  Hideki Hayashi, Misuzu Mori, Mariko Yamada, Bo Yuan, Norio Takagi
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] Apo E-containing lipoproteins protect retinal ganglion cells from glaucomatous optic neuropathy via an LRP1-mediated pathway2018
- Author(s)
  Hideki Hayashi, Misuzu Mori, Mariko Yamada, Bo Yuan, Norio Takagi
- Organizer
  59th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] ラット緑内障モデルのアポE含有リポタンパク質による視神経保護とα2-マクログロブリンの働き2018
- Author(s)
  林　秀樹、森　みすず、山田　まりこ、袁　博、高木　教夫
- Organizer
  第60回　日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] 虚血性神経障害時の LRP1 の変化と神経保護の可能性2018
- Author(s)
  山田まりこ、林秀樹、岩谷結衣、鈴木かおり、袁博、高木教夫
- Organizer
  第１３８回日本薬学会
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] 虚血性脳神経障害時の LRP1 プロセシングと神経生存2018
- Author(s)
  山田まりこ、林秀樹、井上大輔、大畑芽衣子、松嶋菜穂子、袁博、高木教夫
- Organizer
  第60回　日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] A possible neuroprotective mechanism of preventing LRP1 cleavage after ischemic brain damage2018
- Author(s)
  Mariko Yamada, Hideki Hayashi, Yui Iwatani, Kaori Suzuki, Bo Yuan, Norio Takagi
- Organizer
  59th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07376
[Presentation] Apolipoprotein E containing lipoproteins prevent optic nerve degeneration with a reduction of alpha 2 macroglobulin secretion from retinal glia2017
- Author(s)
  Hideki Hayashi, Misuzu Mori, Mina Harashima, Tatsuya Hashizume, Miho Furiya, Hiroko Mori, Bo Yuan, Norio Takagi
- Organizer
  Neuroscience 2017, Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] 中枢神経細胞障害時の LRP1プロセッシングに関わるタンパク質分解酵素と神経生存2017
- Author(s)
  山田まりこ、林秀樹、井上大輔、岩谷結衣、鈴木かおり、袁博、高木教夫
- Organizer
  第９０回日本生化学会
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Pathologic Roles of Proteolytic Enzymes Associated with Receptor Processing2017
- Author(s)
  Mariko Yamada, Hideki Hayashi, Nahoko Matsushima, Meiko Ohata, Bo Yuan, Norio Takagi
- Organizer
  Neuroscience 2017, Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] ラット緑内障モデルのリポタンパク質受容体LRP1を介した視神経保護と網膜グリア細胞の働き2017
- Author(s)
  林　秀樹、森　みすず、橋爪　達哉、原嶋　美奈、降矢　実穂、森　寛子、袁　博、高木　教夫
- Organizer
  第１９回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] 視神経保護におけるアポE含有リポタンパク質とアルファ２-マクログロブリンの働き2017
- Author(s)
  林　秀樹、森　みすず、橋爪　達哉、原嶋　美奈、降矢　実穂、森　寛子、袁　博、高木　教夫
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Neuroprotective roles of apo E-containing lipoproteins against optic nerve degeneration2017
- Author(s)
  Hideki Hayashi
- Organizer
  Bridging Discovery Research with Therapies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] 初代培養大脳皮質神経細胞障害時の LRP1 の変化と LP による神経保護への可能性2017
- Author(s)
  山田まりこ、佐藤祥子、結城もえ、袁博、林秀樹、高木教夫
- Organizer
  第５９回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] リポタンパク質受容体LRP1を介した視神経保護と網膜グリア細胞の働き2017
- Author(s)
  林　秀樹、森　みすず、橋爪　達哉、原嶋　美奈、降矢　実穂、森　寛子、袁　博、高木　教夫
- Organizer
  第９０回日本生化学会
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] 視神経保護におけるアポリポタンパク質E含有リポタンパク質とα2-マクログロブリンの役割2017
- Author(s)
  林　秀樹、森　みすず、橋爪　達哉、原嶋　美奈、降矢　実穂、森　寛子、袁　博、高木　教夫
- Organizer
  第５９回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Antitumor activity of arsenite and tetrandrine, each alone and in combination, against breast cancer cell line MDA-MB-231 in vitro and in vivo.2016
- Author(s)
  Wang X., Yao M., Yuan B., Hayashi H. and Takagi N.
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Neuroprotective functions of apolipoprotein E-containing lipoproteins in neurons and glia of retina.2016
- Author(s)
  H. Hayashi, M. Mori, Y. Ban, B.Yuan, N. Takagi
- Organizer
  Neuroscience 2016, Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] 網膜グリア細胞におけるアポE含有リポタンパク質のα2マクログロブリン発現に及ぼす影響2016
- Author(s)
  森みすず、林秀樹、小沢由、上野栞、伊藤玲奈、坂祐樹、袁博、高木教夫
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Cerebral ischemia-mediated phosphorylation of GSK-3β induced neurogenesis in rats.2016
- Author(s)
  K. Kisoh, H. Hayashi, M. Asada, T. Ito, M. Arai, B. Yuan, N. Takagi
- Organizer
  Neuroscience 2016, Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] 網膜の神経変性に対するアポE含有リポタンパク質の神経保護効果2016
- Author(s)
  林秀樹、森みすず、伊藤玲奈、小沢由、上野栞、坂祐樹、袁博、高木教夫
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] マイクロスフェア誘発脳塞栓後の神経新生におけるGSK-3β情報伝達系の関与2016
- Author(s)
  喜早慧士、林秀樹、浅田眞由美、伊藤剛志、新井美穂、袁博、田野中浩一、高木教夫
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Enhanced antitumor effect of the combination of arsenite with tetrandorine in breast cancer.2015
- Author(s)
  Yao M., Wang X., Yuan B., Sato A., Sakuma K, Kaneko K., Hayashi H., Toyoda H. and Takagi N.
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Delphindin induces cytotoxicity and potentiates cytocidal effect in combination with arsenite in an acute promyelocytic leukemia cell line, NB4.2015
- Author(s)
  Yuan B., Okusumi S., Yoshino Y., Tanaka S., Hirano T., Toyoda H., Hayashi H. and Takagi N.
- Organizer
  14th Meeting of Consortium for Globalization of Chinese Medicine
- Place of Presentation
  Ontario (Canada)
- Year and Date
  2015-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06781
[Presentation] Protective effects of high-density lipoproteins against glutamate-induced neurotoxicity in retinal ganglion cells2014
- Author(s)
  H. Hayashi,and N. Takagi
- Organizer
  2nd Asian International Symposium of Traditional Medicines
- Place of Presentation
  Tokyo University of Pharmacy and Life Sciences (Hachioji)
- Year and Date
  2014-05-10
- Invited
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] ラット脳塞栓後の神経新生に及ぼすGSK－3β情報伝達系の関与2014
- Author(s)
  喜早　慧士，丸ノ内　徹郎，林　秀樹，袁　博，田野中　浩一，高木　教夫
- Organizer
  第58回　日本薬学会関東支部大会
- Place of Presentation
  昭和薬科大学（東京）
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] Cytocidal effects of bufadienolides against human glioblastoma and pancreatic cancer cell lines2014
- Author(s)
  J. He, B. Yuan, H. Hayashi, B. Bian, and N. Takagi
- Organizer
  第58回　日本薬学会関東支部大会
- Place of Presentation
  昭和薬科大学（東京）
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] アポE含有リポプロテインのグルタミン酸誘発神経細胞死に対する保護機構2013
- Author(s)
  林　秀樹
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] グリア細胞由来アポリポ蛋白E含有リポ蛋白による神経細胞死の制御機構2013
- Author(s)
  林　秀樹
- Organizer
  第８４回日本動物学会岡山大会
- Place of Presentation
  岡山
- Invited
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] A protective role of apolipoprotein E-containing lipoproteins in glutamate-induced neurodegeneration.2013
- Author(s)
  Hayashi H
- Organizer
  The Target Meeting’s 2nd World Neuroscience Online Conference
- Place of Presentation
  Online
- Invited
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] Neuroprotection by apolipoprotein E-containing lipoproteins against glaucomatous optic neuropathy.2013
- Author(s)
  林　秀樹
- Organizer
  第８６回日本薬理学会年会
- Place of Presentation
  福岡国際会議場（福岡）
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] Neuroprotection by apolipoprotein E-containing lipoproteins via a low density lipoprotein receptor-related protein-1 against glutamate-induced degeneration in vitro and in vivo.2012
- Author(s)
  Hayashi H.
- Organizer
  11th Biennial Meeting of the Asian Pacific Society for Neurochemistry
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] Low density lipoprotein receptor-related protein-1 mediates the neuroprotection of apolipoprotein E-containing lipoproteins against glutamate neurotoxicity2012
- Author(s)
  HAYASHI, Hideki
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-22790254
[Presentation] Low density lipoprotein receptor-related protein-1 mediates the neuroprotection of apolipoprotein E-containing lipoproteins against glutamate neurotoxicity2012
- Author(s)
  Hayashi H.
- Organizer
  Jpn. J. Pharmacol.第85回日本薬理学会年会
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-22790254
[Presentation] A potential therapeutic role of apolipoprotein E-containing lipoproteins in glaucomatous optic neuropathy.2012
- Author(s)
  Hayashi H.
- Organizer
  Frontiers in Lipid Biology
- Place of Presentation
  バンフセンター、（バンフ）カナダ
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] アポリポプロテインE含有リポプロテインのグルタミン酸神経障害に対する保護作用2012
- Author(s)
  林　秀樹
- Organizer
  第５４回日本脂質生化学会
- Place of Presentation
  九州大学（福岡）
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] Protection from neurodegeneration by apolipoprotein E-containing lipoproteins2011
- Author(s)
  HAYASHI, Hideki
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会館(京都府)(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22790254
[Presentation] Protection from neurodegeneration by apolipoprotein E-containing lipoproteins2011
- Author(s)
  Hayashi H.
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会館(京都)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22790254
[Presentation] アポリポプロテインE含有リポプロテインのアポトーシスに対する神経細胞保護2010
- Author(s)
  林秀樹
- Organizer
  第53回日本神経化学会大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22790254
[Presentation] Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins(Neuro2010)2010
- Author(s)
  Hayashi H., Vance J. E.
- Organizer
  第53回日本神経化学会年会
- Place of Presentation
  神戸国際会議場(神戸)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22790254
[Presentation] Lipoproteins derived from glia protect retinal ganglin cells from apoptosis2009
- Author(s)
  林秀樹
- Organizer
  第4回緑内障サマーキャンプ
- Place of Presentation
  大津プリンスホテル
- Year and Date
  2009-07-31
- Data Source
  KAKENHI-PROJECT-20890174
[Presentation] リポプロテイン受容体による網膜神経節細胞保護機構の解析2009
- Author(s)
  林秀樹
- Organizer
  第2回レチナ・リサーチミーティング
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20890174
[Presentation] Lipoproteins derived from glia protect retinal ganglion cells from apoptosis2009
- Author(s)
  林秀樹
- Organizer
  第4回緑内障サマーキャンプ
- Place of Presentation
  大津プリンスホテル
- Year and Date
  2009-07-31
- Data Source
  KAKENHI-PROJECT-20890174
[Presentation] リポプロテイン受容体による網膜神経節細胞保護機構の解析2009
- Author(s)
  林秀樹
- Organizer
  第2回レチナ・リサーチミーティング
- Place of Presentation
  東京大学医科学研究所
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-20890174
[Presentation] グリア細胞由来リポプロテインによる神経細胞保護シグナルの解析2009
- Author(s)
  林秀樹
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-20890174
[Presentation] アポE含有リポタンパク質とalpha２-マクログロブリンの神経保護効果における役割
- Author(s)
  林　秀樹，袁　博，高木　教夫
- Organizer
  第36回日本生物学的精神医学会第57回日本神経化学会大会合同年会
- Place of Presentation
  奈良文化会館（奈良）
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] グルタミン酸誘発神経障害に対するアポE含有リポプロテインとalpha２-マクログロブリンの神経保護におけるバランス
- Author(s)
  林　秀樹，袁　博，高木　教夫
- Organizer
  第87回　日本生化学会大会
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] ラット脳塞栓後神経新生におけるGSK-3β情報伝達系の関与
- Author(s)
  喜早　慧士，林　秀樹，袁　博，田野中　浩一，高木　教夫
- Organizer
  第88回　日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] Contribution of Akt/MAPK signaling pathways and inhibition of metalloproteinase-2 and 9 expression to gamabufotalin-induced cytotoxicity in human glioblastoma cell line U-87
- Author(s)
  J. He, B. Yuan, H. Hayashi, B. Bian, and N. Takagi
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（神戸）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] アポE含有リポプロテインによる神経保護とその妨害因子の働き
- Author(s)
  林　秀樹，伊藤　玲奈，上野　栞，袁　博，高木　教夫
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（神戸）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] 乳がん細胞MCF-7におけるAsIIIとテトランドリンの併用による殺細胞の増強効果
- Author(s)
  B. Yuan, A. Sato, K. Sakuma, K. Kaneko, H. Hayashi, H. Toyoda, and N. Takagi
- Organizer
  第87回　日本生化学会大会
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] Mechanisms of casticin-induced cytocidal effects against the human promyelocytic cell line HL-60
- Author(s)
  B. Yuan, H. Kikuchi, E. Yuhara, H. Hayashi, N. Takagi, and H. Toyoda
- Organizer
  13th Meeting of Consortium for Globalization of Chinese Medicine (CGCM)
- Place of Presentation
  Beijing (China)
- Year and Date
  2014-08-27 – 2014-08-29
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60
- Author(s)
  B. Yuan, H. Kikuchi, H. Hayashi, H. Toyoda and N. Takagi
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（神戸）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24500441
[Presentation] グリア細胞由来LRP1リガンドの神経保護における役割
- Author(s)
  林　秀樹，小沢　由，袁　博，高木　教夫
- Organizer
  第88回　日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（名古屋）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-24500441

1. 吉川大和 (20274227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 冨塚一磨 (40444640)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 根岸洋一 (50286978)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. VANCE Jean E.

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 藤田恭子 (90447508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 中尾光善

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 谷原秀信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

hayashi hideki 林 秀樹

HAYASHI Hodeki 林 秀樹

Research Projects

Research Products

Co-Researchers

抗LRP1抗体の超音波ナノバブル・イオン液体併用網膜薬物送達による緑内障治療戦略Principal Investigator

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Development of a non-invasive glaucoma treatment using ultrasonic nanobubbles associated with anti-LRP1 antibodyPrincipal Investigator

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The neuroprotective mechanism of lipoproteins for optic nerve degeneration.Principal Investigator

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A study on neuroprotection by glia-derived lipoproteins against nerve injuryPrincipal Investigator

Principal Investigator

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Neuroprotection via lipoprotein receptors against optic neuropathyPrincipal Investigator

Principal Investigator

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A potential treatment of glaucoma by glia-derived lipoproteins.Principal Investigator

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Roles and possible treatment of lipoproteins in diabetic retinopathyPrincipal Investigator

Principal Investigator

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[Book] Neuroprotection and neurodegeneration for retinal diseases2014

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[Book] Oxford University Press, Lipids, lipid mediators and other signaling molecules. Neuroglia, 3rd Edition2012

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[Book] Neuroglia Third Edition2012

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[Journal Article] Effects of laminin-111 peptide coatings on rat neural stem/progenitor cell culture.2021

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[Journal Article] Investigating the Relationship Between Neuronal Cell Death and Early DNA Methylation After Ischemic Injury.2020

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[Journal Article] Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA2019

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[Journal Article] Potential neuroprotective effects of an LSD1 inhibitor in retinal ganglion cells via p38 MAPK-gamma activity2016

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[Journal Article] Effects of Active Bufadienolide Compounds on Human Cancer Cells and CD4+CD25+Foxp3+ Regulatory T Cells in Mitogen-activated Human Peripheral Blood Mononuclear Cells.2016

Author(s)

hayashi hideki 林秀樹

HAYASHI Hodeki 林秀樹