Nishimura Kaneyasu 西村周泰

Researcher Number	90527889
Other IDs	https://orcid.org/0000-0002-5582-3341
Affiliation (Current)	2024: 同志社大学, 研究開発推進機構, 准教授 2024: 同志社大学, 脳科学研究科, 准教授
Affiliation (based on the past Project Information) *help	2024: 同志社大学, 研究開発推進機構, 准教授 2022 – 2023: 同志社大学, 脳科学研究科, 准教授 2019 – 2021: 京都薬科大学, 薬学部, 助教 2014 – 2015: 京都大学, iPS細胞研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurosurgery Except Principal Investigator Basic Section 51010:Basic brain sciences-related / Transformative Research Areas, Section (IV) / Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator パーキンソン病 / 神経再生 / ヒトiPS細胞 / 細胞移植治療 / ドパミン神経 / iPS細胞 / 線条体 / 中脳黒質 / 脳オルガノイド / 神経回路網の再形成 … More / direct reprogramming / 創薬 / シングルセルRNA-seq / ダイレクトリプログラミング / ダイレクトコンバージョン / 神経オルガノイド / ドパミン神経細胞 / 細胞移植 / 細胞運命決定 / ダイレクトコンバーション / 多能性幹細胞 / 細胞接着因子 / エストラジオール / シナプス形成 … More Except Principal Investigator in vivo カルシウムイメージング / ドーパミン / 運動学習 / 運動制御 / 損傷耐性 / バイオ超越 / 多細胞バイオ計算 / Smad2/3 / 移植 / 造血幹細胞 / TGF-β1 / 線条体 / ヒト人工多能性幹細胞 / 多様性 / 疾患関連ミクログリア / 貪食 / イメージング / 化合物 / 神経保護 / 生薬成分 / オルガノイド / アミロイドβ / 病態 / 老化 / アルツハイマー病 / 脳内免疫環境 / ミクログリア Less

モデル動物脳における運動制御の損傷耐性と修復特性
- Principal Investigator
  
  正水芳人
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (IV)
- Research Institution
  Doshisha University
Disease-modeling and neuronal construction using nigro-striatal assembloidPrincipal Investigator
- Principal Investigator
  
  西村周泰
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Doshisha University
神経回路創出により解明する高度な運動学習の神経基盤
- Principal Investigator
  
  正水芳人
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51010:Basic brain sciences-related
- Research Institution
  Doshisha University
脳内免疫環境変化の解析によるアルツハイマー病の病態解明と治療への応用
- Principal Investigator
  
  高田和幸
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyoto Pharmaceutical University
Towards the establishment of new regenerative strategy of midbrain neuronal networksPrincipal Investigator
- Principal Investigator
  
  Nishimura Kaneyasu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyoto Pharmaceutical University
Facilitation of functional synaptic formation between grafted-iPSC-derived dopaminergic neurons and host brain neurons via cell-adhesion moleculePrincipal Investigator
- Principal Investigator
  
  Nishimura Kaneyasu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2016 2015 Other

All Journal Article Presentation Book

[Book] 京都薬科大学紀要2022
- Author(s)
  西村周泰、高田和幸
- Total Pages
  19
- Publisher
  京都薬科大学
- Data Source
  KAKENHI-PROJECT-19K07854
[Book] BIO Clinica2021
- Author(s)
  西村周泰、高田和幸
- Total Pages
  3
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-19K07854
[Book] ファルマシア2021
- Author(s)
  西村周泰
- Total Pages
  2
- Publisher
  日本薬学会
- Data Source
  KAKENHI-PROJECT-19K07854
[Book] BIO Clinica2015
- Author(s)
  西村周泰、高橋淳
- Total Pages
  4
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-26861146
[Journal Article] Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation2023
- Author(s)
  Nishimura Kaneyasu、Yang Shanzheng、Lee Ka Wai、Asgrimsdottir Emilia Sif、Nikouei Kasra、Paslawski Wojciech、Gnodde Sabine、Lyu Guochang、Hu Lijuan、Salto Carmen、Svenningsson Per、Hjerling-Leffler Jens、Linnarsson Sten、Arenas Ernest
- Journal Title
  
  Stem Cell Reports
  
  Volume: 18 Issue: 1 Pages: 337-353
- DOI
  10.1016/j.stemcr.2022.10.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07382
[Journal Article] Plantainoside B in <i>Bacopa monniera</i> Binds to Aβ Aggregates Attenuating Neuronal Damage and Memory Deficits Induced by Aβ2023
- Author(s)
  Fukuda Aina、Nakashima Souichi、Oda Yoshimi、Nishimura Kaneyasu、Kawashima Hidekazu、Kimura Hiroyuki、Ohgita Takashi、Kawashita Eri、Ishihara Keiichi、Hanaki Aoi、Okazaki Mizuki、Matsuda Erika、Tanaka Yui、Nakamura Seikou、Matsumoto Takahiro、Akiba Satoshi、Saito Hiroyuki、Matsuda Hisashi、Takata Kazuyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 2 Pages: 320-333
- DOI
  10.1248/bpb.b22-00797
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06637, KAKENHI-PROJECT-22K06556, KAKENHI-PROJECT-22K07382, KAKENHI-PROJECT-21K15245, KAKENHI-PROJECT-20H03569
[Journal Article] Analysis of Aβ-induced neurotoxicity and microglial responses in simple two- and three-dimensional human iPSC-derived cortical culture systems2023
- Author(s)
  Takata Mayuko、Nishimura Kaneyasu、Harada Koki、Iwasaki Ryota、Ando Momona、Yamada Shiho、Ginhoux Florent、Takata Kazuyuki
- Journal Title
  
  Tissue and Cell
  
  Volume: 81 Pages: 102023-102023
- DOI
  10.1016/j.tice.2023.102023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07382
[Journal Article] CRISPR-Cas9-Edited <i>SNCA</i> Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity2023
- Author(s)
  Inoue Shizen、Nishimura Kaneyasu、Gima Serina、Nakano Mai、Takata Kazuyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 3 Pages: 517-522
- DOI
  10.1248/bpb.b22-00839
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-03-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07382, KAKENHI-PROJECT-20H03569
[Journal Article] Disease modeling using human induced pluripotent stem cell-derived microglia and region-specific neurons2023
- Author(s)
  西村周泰、高田和幸
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 158 Issue: 1 Pages: 52-56
- DOI
  10.1254/fpj.22087
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07382
[Journal Article] Rapid conversion of human induced pluripotent stem cells into dopaminergic neurons by inducible expression of two transcription factors2022
- Author(s)
  Nishimura Kaneyasu、Nitta Tatsumi、Doi Keisuke、Takata Kazuyuki
- Journal Title
  
  Stem Cells and Development
  
  Volume: 印刷中 Issue: 11-12 Pages: 269-277
- DOI
  10.1089/scd.2021.0363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07854, KAKENHI-PROJECT-22K07382, KAKENHI-PROJECT-20H03569
[Journal Article] Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease2022
- Author(s)
  Takata Kazuyuki、Kimura Hiroyuki、Yanagisawa Daijiro、Harada Koki、Nishimura Kaneyasu、Kitamura Yoshihisa、Shimohama Shun、Tooyama Ikuo
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 9 Pages: 2780-2780
- DOI
  10.3390/molecules27092780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07854, KAKENHI-PROJECT-21K06586, KAKENHI-PROJECT-22K07382, KAKENHI-PROJECT-20H03569
[Journal Article] Pharmaceutical approaches in controlling cell fate determination of pluripotent stem cells toward future innovation of regenerative medicine2022
- Author(s)
  西村周泰、高田和幸
- Journal Title
  
  京都薬科大学紀要
  
  Volume: 3 Issue: 1 Pages: 37-55
- DOI
  10.34445/00000294
- ISSN
  2435-4112
- URL
  https://kyoto-phu.repo.nii.ac.jp/records/317
- Year and Date
  2022-07-13
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07382
[Journal Article] Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules2021
- Author(s)
  Amimoto Naoya、Nishimura Kaneyasu、Shimohama Shun、Takata Kazuyuki
- Journal Title
  
  Stem Cell Research
  
  Volume: 55 Pages: 102486-102486
- DOI
  10.1016/j.scr.2021.102486
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07854, KAKENHI-PROJECT-20H03569
[Journal Article] Combination of Drugs and Cell Transplantation: More Beneficial Stem Cell-Based Regenerative Therapies Targeting Neurological Disorders2021
- Author(s)
  Nishimura Kaneyasu、Takata Kazuyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 9047-9047
- DOI
  10.3390/ijms22169047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07854, KAKENHI-PROJECT-20H03569
[Journal Article] 中脳ドパミン神経の機能再生治療法の開発2021
- Author(s)
  西村周泰、高田和幸
- Journal Title
  
  BIO Clinica
  
  Volume: 36 Pages: 87-89
- Data Source
  KAKENHI-PROJECT-19K07854
[Journal Article] Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ2020
- Author(s)
  Kuroda E, Nishimura K, Kawanishi S, Sueyoshi M, Ueno F, Toji Y, Abo N, Konishi T, Harada K, Satake S, Shima C, Toda Y, Kitamura Y, Shimohama S, Ashihara E, Takata K.
- Journal Title
  
  Neuroscience
  
  Volume: 438 Pages: 217-228
- DOI
  10.1016/j.neuroscience.2020.05.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17388, KAKENHI-PROJECT-20H03569, KAKENHI-PROJECT-18K06904
[Journal Article] 中脳ドパミン神経回路網の機能再生・修復を目指した新規治療戦略2020
- Author(s)
  西村周泰、高田和幸
- Journal Title
  
  Medical Science Digest
  
  Volume: 46 Pages: 36-38
- Data Source
  KAKENHI-PROJECT-19K07854
[Journal Article] Estradiol facilitates functional integration of induced pluripotent stem cell-derived dopaminergic neurons into striatal neuronal circuits via activation of integrin α5β12016
- Author(s)
  Kaneyasu Nishimura, Daisuke Doi, Bumpei Samata, Shigeo Murayama, Tsuyoshi Tahara, Hirotaka Onoe, Jun Takahashi
- Journal Title
  
  Stem Cell Reports
  
  Volume: 6 Issue: 4 Pages: 511-524
- DOI
  10.1016/j.stemcr.2016.02.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J02729, KAKENHI-PROJECT-26861146, KAKENHI-PROJECT-16H06277
[Presentation] Bacopa monnieraに含有されるAβ結合物質plantainoside BによるAβ凝集体の検出と神経保護作用2023
- Author(s)
  福田愛菜, 中嶋聡一, 尾田好美, 西村周泰, 河嶋秀和, 木村寛之, 扇田隆司, 河下映里, 石原慶一, 花木葵, 岡崎瑞紀, 松田英里香, 田中雪衣, 中村誠宏, 松本崇宏, 秋葉聡, 斎藤博幸, 松田久司, 高田和幸
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] 転写因子の誘導性発現によるヒト人工多能性幹細胞からドパミン神経への転換的誘導法の開発2023
- Author(s)
  西村周泰
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K07382
[Presentation] Establishment of induction protocol for human midbrain neurons by decoding human midbrain development2023
- Author(s)
  西村周泰
- Organizer
  第21回武田科学振興財団生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K07382
[Presentation] Effects of Down syndrome genes on amyloid-β aggregation in mice2022
- Author(s)
  Keiichi Ishihara, Eri Kawashita, Kaneyasu Nishimura, Michiko Saito, Haruhiko Sago, Kazuhiro Yamakawa, Satoshi Akiba, Kazuyuki Takata
- Organizer
  The 65th Annual Meeting of the Japanese Society for Neurochemistry
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] 生薬由来低分子化合物のAβ神経毒性に対する保護作用とAβイメージングに向けた解析2022
- Author(s)
  福田愛菜、中嶋聡一、尾田好美、西村周泰、花木葵、河嶋秀和、木村寛之、中村誠宏、松本崇宏、高田和幸
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] 黒質線条体経路を再現する多領域性を持つ脳モデルの作製2022
- Author(s)
  西村周泰、網本直弥、中野舞、高田和幸
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-19K07854
[Presentation] Towards understanding the pathology of Parkinson’s disease using imaging and iPSC technology2022
- Author(s)
  Kaneyasu Nishimura
- Organizer
  Novel Approaches on PET Research - Total-body Imaging, Radiopharmaceuticals, and Machine Learning
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07382
[Presentation] Roles of nicotinic acetylcholine receptors on the differentiation of pluripotent stem cell-derived primitive macrophages and dopaminergic neurons2022
- Author(s)
  Koki Harada, Takeshi Kato, Masahiro Hirao, Kaneyasu Nishimura, Shun Shimohama, Kazuyuki Takata
- Organizer
  The 65th Annual Meeting of the Japanese Society for Neurochemistry
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] 生薬由来Aβ結合性低分子化合物の神経保護作用の解析2022
- Author(s)
  松田英里香、福田愛菜、中嶋聡一、尾田好美、花木葵、河嶋秀和、木村寛之、岡崎瑞紀、田中雪衣、中村誠宏、松田久司、西村周泰、高田和幸
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] 発生原理の再現によるミクログリアの誘導と脳領域特異的な神経誘導技術を用いた病態の解析と神経機能再生研究基盤の確立に向けて2022
- Author(s)
  西村周泰、高田和幸
- Organizer
  第95回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07854
[Presentation] Bacopa monniera由来Aβ結合性低分子化合物によるAβの検出と神経保護作用の解析2022
- Author(s)
  福田愛菜、中嶋聡一、尾田好美、西村周泰、花木葵、河嶋秀和、木村寛之、中村誠宏、松本崇宏、岡崎瑞紀、松田英里香、田中雪衣、松田久司、高田和幸
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] CRISPR-Cas9システムを用いて作製したα-シヌクレインノックアウトヒトiPS細胞を活用した神経毒に対する脆弱性の検討2022
- Author(s)
  西村周泰
- Organizer
  第16回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K07382
[Presentation] 黒質線条体経路を再現する多領域性を持つ脳モデルの作製2022
- Author(s)
  西村周泰、網本直弥、中野舞、高田和幸
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] 二次元および三次元培養法による低分子化合物を用いたヒトiPS細胞から線条体神経細胞への分化誘導法の開発2021
- Author(s)
  西村周泰、網本直弥、高田和幸
- Organizer
  第44回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K07854
[Presentation] 低分子化合物を用いたシグナルコントロールによるヒト多能性幹細胞から黒質・線条体神経細胞の作製2021
- Author(s)
  西村周泰、網本直弥、加藤丈使、平尾真大、高田和幸
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07854
[Presentation] iPS細胞由来マクロファージおよびドパミン神経の分化におけるアセチルコリン受容体の役割2021
- Author(s)
  原田考輝、加藤丈使、西村周泰、平尾真大、下濱俊、高田和幸
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] Direct conversionによるヒトiPS細胞からドパミン神経への簡便で迅速な誘導法の開発2021
- Author(s)
  西村周泰、仁田達海、土居佳祐、高田和幸
- Organizer
  第15回次世代を担う若手のための医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07854
[Presentation] 脳オルガノイドを活用した脳内免疫環境変化の解析と認知症の病態解明への応用2021
- Author(s)
  高田和幸、高田真優子、西村周泰
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] 骨髄細胞由来ミクログリア様細胞のミクログリアとの相互作用ならびにニコチン受容体刺激による機能制御の解析2020
- Author(s)
  末吉真梨、西村周秦、北村佳久、芦原英司、下濱俊、高田和幸
- Organizer
  第70回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] 低分子化合物を用いたヒトiPS細胞から脳領域特異的神経細胞の誘導制御と応用法の提案2020
- Author(s)
  西村周泰、網本直弥、加藤丈使、高田真優子、福田愛菜、平尾真大、高田和幸
- Organizer
  第10回 4大学連携研究フォーラム
- Data Source
  KAKENHI-PROJECT-19K07854
[Presentation] 認知症の細胞治療戦略開発に向けた幹細胞由来ミクログリア様細胞の機能解析とその制御2020
- Author(s)
  末吉真梨、西村周泰、芦原英司、下濱俊、高田和幸
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-20H03569
[Presentation] 幹細胞技術を基盤とした神経変性疾患に対する再生創薬研究2020
- Author(s)
  西村周泰、高田和幸
- Organizer
  第14回次世代を担う若手のための医療薬科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K07854
[Presentation] トランスシナプストレーサーを用いた中脳ドパミン神経支配を受ける線条体神経の組織学的特性解析
- Author(s)
  西村周泰、髙橋淳
- Organizer
  第37回日本神経科学学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26861146

1. 正水芳人 (90608530)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 尾崎弘展 (30747697)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 高田和幸 (10434664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. 石原慶一 (80340446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 戸田侑紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishimura Kaneyasu 西村 周泰

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モデル動物脳における運動制御の損傷耐性と修復特性

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Disease-modeling and neuronal construction using nigro-striatal assembloidPrincipal Investigator

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神経回路創出により解明する高度な運動学習の神経基盤

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脳内免疫環境変化の解析によるアルツハイマー病の病態解明と治療への応用

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Towards the establishment of new regenerative strategy of midbrain neuronal networksPrincipal Investigator

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Facilitation of functional synaptic formation between grafted-iPSC-derived dopaminergic neurons and host brain neurons via cell-adhesion moleculePrincipal Investigator

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[Book] 京都薬科大学紀要2022

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[Book] BIO Clinica2021

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[Book] ファルマシア2021

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[Book] BIO Clinica2015

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[Journal Article] Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation2023

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[Journal Article] Plantainoside B in <i>Bacopa monniera</i> Binds to Aβ Aggregates Attenuating Neuronal Damage and Memory Deficits Induced by Aβ2023

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[Journal Article] Analysis of Aβ-induced neurotoxicity and microglial responses in simple two- and three-dimensional human iPSC-derived cortical culture systems2023

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[Journal Article] CRISPR-Cas9-Edited <i>SNCA</i> Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity2023

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Nishimura Kaneyasu 西村周泰