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Furukohri Asako  古郡 麻子

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FURUKOHRI Asako  古郡 麻子

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Researcher Number 90546293
Other IDs
Affiliation (Current) 2025: 大阪大学, 蛋白質研究所, 准教授
Affiliation (based on the past Project Information) *help 2018 – 2024: 大阪大学, 蛋白質研究所, 准教授
2017: 大阪大学, たんぱく質研究所, 准教授
2013 – 2016: 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教
2009 – 2010: Nara Institute of Science and Technology, バイオサイエンス研究科, 助教
Review Section/Research Field
Principal Investigator
Molecular biology / Basic Section 43010:Molecular biology-related / Complex systems
Keywords
Principal Investigator
DNA修復 / DNA二本鎖切断 / 相同組換え / Mre11 / 二本鎖DNA切断 / 高速AFM / Mrer11 complex / Mre11 complex / 大腸菌 / 突然変異 / DNA複製
  • Research Projects

    (5 results)
  • Research Products

    (47 results)
  • Co-Researchers

    (5 People)
  •  MRNによる相同組換え開始機構の生化学的解析Principal Investigator

    • Principal Investigator
      古郡 麻子
    • Project Period (FY)
      2019 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43010:Molecular biology-related
    • Research Institution
      Osaka University
  •  ヒトMRNの動的構造解析が明らかにするDNA二本鎖切断修復の分子メカニズムPrincipal Investigator

    • Principal Investigator
      古郡 麻子
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Osaka University
  •  Biochemical analysis of Human Mre11 complex working in DNA double-strand break repairPrincipal Investigator

    • Principal Investigator
      Furukohri Asako
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      Osaka University
      Nara Institute of Science and Technology
  •  Regulatory mechanism controlling a novel nuclease activity of Mre11 complex on structured DNAPrincipal Investigator

    • Principal Investigator
      FURUKOHRI Asako
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Molecular biology
    • Research Institution
      Nara Institute of Science and Technology
  •  Analysis of translesion synthesis at replication fork in vitroPrincipal Investigator

    • Principal Investigator
      FURUKOHRI Asako
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Molecular biology
    • Research Institution
      Nara Institute of Science and Technology

All 2023 2021 2020 2019 2018 2017 2016 2015 2014 2011 2010 Other

All Journal Article Presentation Book

  • [Book] Elsevier2011

    • Author(s)
      Hisaji Maki, Asako Furukohri
    • Publisher
      The Encyclopedia of Biological Chemistry second edition(in pres)
    • Data Source
      KAKENHI-PROJECT-21870023
  • [Journal Article] Fanconi anemia-associated mutation in RAD51 compromises the coordinated action of DNA-binding and ATPase activities.2023

    • Author(s)
      Liu S, Shinohara A, Furukohri A.
    • Journal Title

      J Biol Chem.

      Volume: 299(12) Issue: 12 Pages: 105424-105424

    • DOI

      10.1016/j.jbc.2023.105424

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Journal Article] The role of conserved amino acid residues of Sae3 in Mei5–Sae3 complex for Dmc1 assembly in meiotic recombination2023

    • Author(s)
      Sawant P, Mwaniki S, Fujita Y, Ito M, Furukohri A, Shinohara A.
    • Journal Title

      Genes Genet. Syst.

      Volume: 98 Issue: 1 Pages: 45-52

    • DOI

      10.1266/ggs.23-00015

    • ISSN
      1341-7568, 1880-5779
    • Year and Date
      2023-02-01
    • Language
      English
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Journal Article] FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination2023

    • Author(s)
      Ito Masaru、Furukohri Asako、Matsuzaki Kenichiro、Fujita Yurika、Toyoda Atsushi、Shinohara Akira
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 6857-6857

    • DOI

      10.1038/s41467-023-42576-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K18036, KAKENHI-PROJECT-20K15716, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-23K20059
  • [Journal Article] Nutritional conditions and oxygen concentration affect spontaneous occurrence of homologous recombination events but not spontaneous mutagenesis in <i>Escherichia coli</i>2020

    • Author(s)
      Le Lan Anh Thi、Chang Phooi Yee、Ando Sayaka、Conrad Thomas M.、Nunose Shohei、Sakai Akiko、Uefune Haruka、Furukohri Asako、Akiyama Masahiro Tatsumi、Maki Hisaji
    • Journal Title

      Genes Genet. Syst.

      Volume: 95 Issue: 2 Pages: 85-93

    • DOI

      10.1266/ggs.19-00008

    • NAID

      130007871342

    • ISSN
      1341-7568, 1880-5779
    • Year and Date
      2020-04-01
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-23K20059
  • [Journal Article] Rad50 zinc hook functions as a constitutive dimerization module interchangeable with SMC hinge2020

    • Author(s)
      Tatebe Hisashi、Lim Chew Theng、Konno Hiroki、Shiozaki Kazuhiro、Shinohara Akira、Uchihashi Takayuki、Furukohri Asako
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 370-370

    • DOI

      10.1038/s41467-019-14025-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06542, KAKENHI-PROJECT-19K06596, KAKENHI-PLANNED-15H05973, KAKENHI-PUBLICLY-18H04512, KAKENHI-PUBLICLY-19H05389, KAKENHI-PROJECT-18H01837, KAKENHI-PROJECT-16K07255, KAKENHI-PROJECT-19H00981, KAKENHI-PROJECT-23K20059
  • [Journal Article] Collision with duplex DNA renders Escherichia coli DNA polymerase III holoenzyme susceptible to DNA polymerase IV-mediated polymerase switching on the sliding clamp2017

    • Author(s)
      Thanh Thi Le, Asako Furukohri, Masahiro Tatsumi-Akiyama and Hisaji Maki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1

    • DOI

      10.1038/s41598-017-13080-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Journal Article] Long inverted repeat transiently stalls DNA replication by forming hairpin structures on both leading and lagging strands2016

    • Author(s)
      Lai P.J., Lim C.T., Le H.P., Katayama T., Leach D.R.F, Furukohri A*., Maki H.
    • Journal Title

      Genes to Cells

      Volume: 21 Issue: 2 Pages: 136-145

    • DOI

      10.1111/gtc.12326

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25840009, KAKENHI-PROJECT-25291077
  • [Journal Article] Recombinase and translesion DNA polymerase decrease the speed of replication fork progression during the DNA damage response in Escherichia coli cells.2015

    • Author(s)
      Tan K.W., Pham M.T., Furukohri A, Maki H. and Akiyama T.M.
    • Journal Title

      Nucleic Acids Research

      Volume: 43 Issue: 3 Pages: 1715-1725

    • DOI

      10.1093/nar/gkv044

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-25840009
  • [Journal Article] A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex2015

    • Author(s)
      Lim C.T., Lai P.J., Leach D.R.F, Maki H., Furukohri A
    • Journal Title

      Nucleic Acids Research

      Volume: 43 Pages: 9804-9816

    • DOI

      10.1093/nar/gkv855

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25840009, KAKENHI-PROJECT-25291077
  • [Journal Article] Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork.2015

    • Author(s)
      Le HP, Masuda Y, Tsurimoto T, Maki S, Katayama T, Furukohri A, Maki H.
    • Journal Title

      Genes Cells.

      Volume: 10 Issue: 10 Pages: 817-833

    • DOI

      10.1111/gtc.12275

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25440011, KAKENHI-PUBLICLY-26114714, KAKENHI-PROJECT-15H02818, KAKENHI-PROJECT-25840009, KAKENHI-PROJECT-25291077
  • [Journal Article] DNA polymeraes IV mediates efficient and quick recovery at N2-dG adducts.2014

    • Author(s)
      Ikeda M, Furukohri A, Philippin G, Loechler E, Akiyama MT, Katayama T, Fuchs RP, Maki H.
    • Journal Title

      Nucleic Acids Research

      Volume: 42 Issue: 13 Pages: 8461-8472

    • DOI

      10.1093/nar/gku547

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25131713, KAKENHI-PROJECT-25291077, KAKENHI-PROJECT-25440009, KAKENHI-PROJECT-25840009
  • [Journal Article] Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication.2011

    • Author(s)
      Kundu LR, Seki M, Watanabe N, Murofushi H, Furukohri A, Waga S, Score AJ, Blow JJ, Horikoshi M, Enomoto T, Tada S.
    • Journal Title

      Biochim Biophys Acta. 1813(6)

      Pages: 1129-1136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870023
  • [Journal Article] Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.2010

    • Author(s)
      Kundu LR, Kumata Y, Kakusho N, Watanabe S, Furukohri A, Waga S, Seki M, Masai H, Enomoto T, Tada S.
    • Journal Title

      Nucleic Acids Res. 38(16)

      Pages: 5409-5418

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870023
  • [Presentation] The analysis of the dynamic structures and functions of enzymes working in DNA double-strand break repair2023

    • Author(s)
      Asako Furukohri
    • Organizer
      日本生化学会第96回大会
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] DNA二本鎖切断修復で働くMRE11-RAD50-NBS1複合体の動的構造解析2021

    • Author(s)
      古郡麻子
    • Organizer
      染色体ワークショップ
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] 蛋白質複合体の動的構造解析によるDNA二本鎖切断修復機構の解明2020

    • Author(s)
      古郡麻子
    • Organizer
      第92回日本遺伝学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] DNA二本鎖切断修復で働くMRE11-RAD50-NBS1複合体の動的構造解析2020

    • Author(s)
      古郡麻子
    • Organizer
      第63回日本放射線影響学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] ヒトMRN複合体の構造と非B型DNAに対するヌクレアーゼ活性の解析2020

    • Author(s)
      古郡麻子
    • Organizer
      第93回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] Revealing the dynamic structures and functions of human MRE11/RAD50/NBS1 complex working in DNA damage response2020

    • Author(s)
      古郡麻子
    • Organizer
      第43回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] Biochemical analysis of DNA polymerase actions across the trinucleotide repeats2019

    • Author(s)
      古郡 麻子
    • Organizer
      第92回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] ヒトDMC1による減数分裂期組換え機構の生化学的解析2019

    • Author(s)
      荒井麻里、篠原彰、古郡麻子
    • Organizer
      第25回DNA複製・修復・組換えワークショップ
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] DNA二本鎖切断修復機構で働くヒトMRN複合体の動的構造解析2019

    • Author(s)
      古郡 麻子
    • Organizer
      第25回DNA複製・修復・組換えワークショップ
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] Biochemical analysis of human RAD51-mediated recombination during meiosis2019

    • Author(s)
      Liu SIJIA, Akira Shinohara, Asako Furukohri
    • Organizer
      第25回DNA複製・修復・組換えワークショップ
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] Biochemical analysis of DNA polymerase actions across the trinucleotide repeats2019

    • Author(s)
      古郡 麻子
    • Organizer
      第92回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] DNA二本鎖切断修復機構で働くヒトMre11/Ra50/Nbs1複合体の動的構造解析2019

    • Author(s)
      古郡 麻子
    • Organizer
      第 42 回日本分子生物学会大会
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] DNA二本鎖切断修復機構で働くヒトMRN複合体の動的構造解析2019

    • Author(s)
      古郡 麻子
    • Organizer
      第25回DNA複製・修復・組換えワークショップ
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] DNA二本鎖切断修復機構で働くヒトMre11/Ra50/Nbs1複合体の動的構造解析2019

    • Author(s)
      古郡 麻子
    • Organizer
      第42回 日本分子生物学会大会
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] ヒトDMC1による減数分裂期組換え機構の生化学的解析2019

    • Author(s)
      荒井麻里、篠原彰、古郡麻子
    • Organizer
      第42回 日本分子生物学会大会
    • Data Source
      KAKENHI-PROJECT-23K20059
  • [Presentation] DNA二本鎖切断修復機構で働くMre11/Ra50/Nbs1複合体の構造と機能2018

    • Author(s)
      古郡 麻子
    • Organizer
      日本生化学会第91回大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05883
  • [Presentation] DNA二本鎖切断修復機構で働くMre11/Ra50/Nbs1複合体の構造と機能2018

    • Author(s)
      古郡 麻子
    • Organizer
      日本遺伝学会第90回大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05883
  • [Presentation] DNA二本鎖切断修復機構で働くヒトMre11/Ra50/Nbs1複合体の動的構造解析2018

    • Author(s)
      古郡 麻子
    • Organizer
      第41回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05883
  • [Presentation] DNA二本鎖切断修復機構で働くMre11/Ra50/Nbs1複合体の構造と機能2018

    • Author(s)
      古郡 麻子
    • Organizer
      日本遺伝学会第90回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] DNA二本鎖切断修復機構で働くMre11/Ra50/Nbs1複合体の構造と機能2018

    • Author(s)
      古郡 麻子
    • Organizer
      日本生化学会第91回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] DNA二本鎖切断修復機構で働くヒトMre11/Ra50/Nbs1複合体の動的構造解析2018

    • Author(s)
      古郡 麻子
    • Organizer
      第41回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] DSB修復で働くMre11/Rad50複合体の生化学的解析2017

    • Author(s)
      古郡 麻子、 Chew Theng Lim、 David R.F. Leach、 真木 壽治
    • Organizer
      日本遺伝学会第89回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] Biochemical analysis on nuclease activities of Mre11/Rad50 complex2017

    • Author(s)
      Asako Furukohri
    • Organizer
      IPR seminar: Chromosome dynamics and genome stability in meiosis and mitosis
    • Place of Presentation
      大阪大学蛋白質研究所、大阪府吹田市
    • Year and Date
      2017-03-23
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] DNA二本鎖切断修復機構で働くMre11/Rad50/Nbs1複合体の解析2017

    • Author(s)
      古郡 麻子
    • Organizer
      2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] DNA二本鎖切断修復機構で働くMre11/Rad50/Nbs1複合体の解析2017

    • Author(s)
      古郡 麻子
    • Organizer
      2017年度生命科学系学会合同年次大会(第40回日本分子生物学会)
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05883
  • [Presentation] DSB修復で働くMre11/Rad50複合体の生化学的解析2017

    • Author(s)
      古郡 麻子、Chew Theng Lim、David F Leach、真木 寿治
    • Organizer
      日本遺伝学会第89回大会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05883
  • [Presentation] Biochemical analysis reveals a novel action of bacterial Mre11/Rad50 complex (SbcCD) at a DNA end2016

    • Author(s)
      Asako Furukohri
    • Organizer
      10th 3R International Symposium
    • Place of Presentation
      ホテル一畑、鳥取県松江市
    • Year and Date
      2016-11-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07255
  • [Presentation] Biochemical analysis reveals a novel action of bacterial Mre11/Rad50 complex2015

    • Author(s)
      古郡 麻子、Lim Chew Theng、David R.F. Leach、真木 寿治
    • Organizer
      日本遺伝学会第87回大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-09-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-25840009
  • [Presentation] 大腸菌損傷乗り越え型DNA Polymerase IVの複製フォークにおける役割2015

    • Author(s)
      古郡 麻子、池田 美央、秋山 昌広、片山 勉、Robert P. Fuchs、真木 寿治
    • Organizer
      第12回21世紀大腸菌研究会
    • Place of Presentation
      琵琶湖グランドホテル(滋賀県大津市)
    • Year and Date
      2015-06-04
    • Data Source
      KAKENHI-PROJECT-25840009
  • [Presentation] 大腸菌Mre11/Rad50ホモログSbcCDの新規DNA末端依存的二本鎖DNA切断活性の生化学的解析2015

    • Author(s)
      古郡 麻子、Lim Chew Theng、David R.F. Leach、真木 寿治
    • Organizer
      第23回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      焼津グランドホテル(静岡県焼津市)
    • Year and Date
      2015-10-19
    • Data Source
      KAKENHI-PROJECT-25840009
  • [Presentation] Overproduction of Escherichia coli DNA Polymerase DinB(Pol IV) Inhibits Replication Fork Progression and is Lethal.2010

    • Author(s)
      Uchida K, Furukohri A, Shinozaki Y.Mori T, Ogawara D, Kanaya S, Nohmi T, Maki H, Akiyama M
    • Organizer
      The 57th NIBB Conference THE DYNAMIC GENOME
    • Place of Presentation
      Okazaki Conference Center, Okazaki, Aichi, Japan
    • Year and Date
      2010-10-14
    • Data Source
      KAKENHI-PROJECT-21870023
  • [Presentation] Escherichia coli DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts

    • Author(s)
      Asako Furukohri, Mio Ikeda, Masahiro Tatsumi Akiyama, Tsutomu Katayama, Robert P. Fuchs and Hisaji Maki
    • Organizer
      DNA polymerases: Biology, Diseases and Biomedical Applications Conference 2014
    • Place of Presentation
      Robinson College, Cambridge, England, UK
    • Year and Date
      2014-08-31 – 2014-09-04
    • Data Source
      KAKENHI-PROJECT-25840009
  • [Presentation] Escherichia coli DNA polymerase IV mediates efficient and quick recovery of replication forks stalled at N2-dG adducts

    • Author(s)
      Asako Furukohri, Mio Ikeda, Masahiro Tatsumi Akiyama, Tsutomu Katayama, Robert P. Fuchs and Hisaji Maki
    • Organizer
      The 9th 3R Symposium
    • Place of Presentation
      御殿場高原ホテル、御殿場市
    • Year and Date
      2014-11-17 – 2014-11-21
    • Data Source
      KAKENHI-PROJECT-25840009
  • 1.  建部 恒 (00596819)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  篠原 彰 (00252578)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 3.  真木 寿治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 4.  藤田 侑里香
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  釣本 敏樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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