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Kuroki Kimiko  黒木 喜美子

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KUROKI Kimiko  黒木 喜美子

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Researcher Number 90553313
Other IDs
External Links
Affiliation (Current) 2025: 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help 2024 – 2025: 北海道大学, 薬学研究院, 教授
2022 – 2023: 北海道大学, 薬学研究院, 准教授
2018 – 2020: 北海道大学, 薬学研究院, 准教授
2011 – 2014: 北海道大学, 薬学研究科(研究院), 助教
2011 – 2012: 北海道大学, 大学院・薬学研究院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Biological Sciences / Basic Section 43020:Structural biochemistry-related / Functional biochemistry / Structural biochemistry
Keywords
Principal Investigator
LILR / 構造解析 / HLA-G / 免疫チェックポイント / 抗体 / 相互作用解析 / ホモ二量体 / HLA-G6 / 強直性脊椎炎 / HLA-B27 … More / アイソフォーム / 抗体医薬品 / 免疫抑制 / 免疫寛容 / 立体構造解析 / バイオ医薬品 / ANGPTL2 / HLA-G2 / LILRB2 / 抗炎症効果 / PIR-B / CIAマウス / 表面プラスモン共鳴法 / 電子顕微鏡解析 / 化合物スクリーニング / NMR / 電子顕微鏡 / X線結晶構造解析 Less
  • Research Projects

    (7 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (2 People)
  •  免疫抑制分子HLA-Gの機能理解・制御を目指した機能性抗体開発Principal Investigator

    • Principal Investigator
      黒木 喜美子
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      Hokkaido University
  •  免疫抑制分子HLA-Gアイソフォームを特異的に機能阻害する腫瘍治療抗体医薬品開発Principal Investigator

    • Principal Investigator
      黒木 喜美子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
    • Research Institution
      Hokkaido University
  •  Molecular recognition of immune inhibitory receptor, LILRB2, with HLA-G2 and various ligandsPrincipal Investigator

    • Principal Investigator
      Kuroki Kimiko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Hokkaido University
  •  強直性脊椎炎病因蛋白質HLA-B27の受容体LILRB2を介した発症機構の解明Principal Investigator

    • Principal Investigator
      黒木 喜美子
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Structural analysis of HLA-G6 isoform bound to LILRB2 receptorPrincipal Investigator

    • Principal Investigator
      KUROKI KIMIKO
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Hokkaido University
  •  強直性脊椎炎病因蛋白質HLA-B27ホモ二量体の立体構造解析Principal Investigator

    • Principal Investigator
      黒木 喜美子
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Hokkaido University
  •  Molecular recognition of HLA-G6 isoform with LILR familyPrincipal Investigator

    • Principal Investigator
      KUROKI Kimiko
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Hokkaido University

All 2024 2023 2021 2020 2019 2018 2015 2014 2013 2012 2011

All Journal Article Presentation

  • [Journal Article] Efficient preparation of human and mouse CD1d proteins using silkworm baculovirus expression system2020

    • Author(s)
      Kusaka Hiroki、Kita Shunsuke、Tadokoro Takashi、Yoshida Kouki、Kasai Yoshiyuki、Niiyama Harumi、Fujimoto Yukari、Hanashima Shinya、Murata Michio、Sugiyama Shigeru、Ose Toyoyuki、Kuroki Kimiko、Maenaka Katsumi
    • Journal Title

      Protein Expression and Purification

      Volume: 172 Pages: 105631-105631

    • DOI

      10.1016/j.pep.2020.105631

    • NAID

      120007147244

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K16051, KAKENHI-PROJECT-17K07296, KAKENHI-PROJECT-20K06529, KAKENHI-PROJECT-18KK0194, KAKENHI-PUBLICLY-19H04634, KAKENHI-PROJECT-18K06073, KAKENHI-PUBLICLY-19H04815, KAKENHI-PROJECT-19H00918
  • [Journal Article] Therapeutic effects of soluble human leukocyte antigen G2 isoform in lupus-prone MRL/lpr mice2020

    • Author(s)
      Watanabe Hiroshi、Kuroki Kimiko、Yamada Chisato、Saburi Yukari、Maeda Naoyoshi、Maenaka Katsumi
    • Journal Title

      Human Immunology

      Volume: 81 Issue: 4 Pages: 186-190

    • DOI

      10.1016/j.humimm.2019.11.002

    • NAID

      120007034052

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06073, KAKENHI-PROJECT-17K08848, KAKENHI-PROJECT-20K07523
  • [Journal Article] Evaluation of the Reactivity and Receptor Competition of HLA-G Isoforms toward Available Antibodies: Implications of Structural Characteristics of HLA-G Isoforms2019

    • Author(s)
      Furukawa Atsushi、Meguro Manami、Yamazaki Rika、Watanabe Hiroshi、Takahashi Ami、Kuroki Kimiko、Maenaka Katsumi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 23 Pages: 5947-5947

    • DOI

      10.3390/ijms20235947

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06073, KAKENHI-PROJECT-18K14633
  • [Journal Article] Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms2019

    • Author(s)
      Kuroki Kimiko、Matsubara Haruki、Kanda Ryo、Miyashita Naoyuki、Shiroishi Mitsunori、Fukunaga Yuko、Kamishikiryo Jun、Fukunaga Atsushi、Fukuhara Hideo、Hirose Kaoru、Hunt Joan S.、Sugita Yuji、Kita Shunsuke、Ose Toyoyuki、Maenaka Katsumi
    • Journal Title

      The Journal of Immunology

      Volume: 203 Issue: 12 Pages: 3386-3394

    • DOI

      10.4049/jimmunol.1900562

    • NAID

      120007018379

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06073, KAKENHI-PROJECT-19K06514, KAKENHI-PROJECT-18KK0194, KAKENHI-PROJECT-19H00918, KAKENHI-PROJECT-17K07296, KAKENHI-PUBLICLY-19H04634
  • [Journal Article] The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.2013

    • Author(s)
      Kuroki Kら
    • Journal Title

      Hum Immunol.

      Volume: 74 Issue: 4 Pages: 433-438

    • DOI

      10.1016/j.humimm.2012.11.060

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22370043, KAKENHI-PROJECT-23770102, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-25709080
  • [Journal Article] Structural and functional mosaic nature of MHC class I molecules in their peptide-free form.2013

    • Author(s)
      E.Kurimoto, K.Kuroki, Y.Yamaguchi, M.Yagi-Utsumi, T.Igaki, T.Iguchi, K.Maenaka, and K.Kato
    • Journal Title

      Mol. Immunol.

      Volume: 55 Issue: 3-4 Pages: 393-399

    • DOI

      10.1016/j.molimm.2013.03.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20107004, KAKENHI-PROJECT-23770102, KAKENHI-PROJECT-23870043
  • [Journal Article] Molecular recognition of paired receptors in the immune system.2012

    • Author(s)
      Kuroki K, et al.
    • Journal Title

      Front Microbiol.

      Volume: 3 Pages: 429-429

    • DOI

      10.3389/fmicb.2012.00429

    • Data Source
      KAKENHI-PUBLICLY-23133501
  • [Journal Article] Analysis of receptor-ligand interactions by surface plasmon resonance2011

    • Author(s)
      Kuroki K, Maenaka K
    • Journal Title

      Methods Mol Biol

      Volume: 748 Pages: 83-106

    • DOI

      10.1007/978-1-61779-139-0_6

    • ISBN
      9781617791383, 9781617791390
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23133501
  • [Journal Article] Molecular basis for LLT1 recognition by human CD161 (NKRP1A/KLRB1)2011

    • Author(s)
      Kamishikiryo, ら
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Issue: 27 Pages: 23823-23830

    • DOI

      10.1074/jbc.m110.214254

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22121007, KAKENHI-PROJECT-23770102
  • [Journal Article] Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT2011

    • Author(s)
      Rieko Kojima, et al
    • Journal Title

      Journal of Molecular Biology

      Volume: 413(4) Issue: 4 Pages: 762-772

    • DOI

      10.1016/j.jmb.2011.09.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J03326, KAKENHI-PLANNED-22121007, KAKENHI-PROJECT-22370043, KAKENHI-PROJECT-23770102
  • [Presentation] Immunoregulatory mechanisms mediated by a novel receptor for the immunosuppressive protein HLA-G22024

    • Author(s)
      Hiroshi Watanabe, Kimiko Kuroki, Katsumi Maenaka
    • Organizer
      第52回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K24012
  • [Presentation] 免疫抑制蛋白質製剤としての開発に向けたHLA-G2の発現系の検討2023

    • Author(s)
      山本 亮太,黒木 喜美子,渡邊 紘士,前仲 勝実
    • Organizer
      日本薬学会北海道支部第150回例会
    • Data Source
      KAKENHI-PROJECT-23K24012
  • [Presentation] 免疫抑制分子HLA-G2のバイオ医薬品開発に向けた哺乳細胞発現系の検討2023

    • Author(s)
      山本 亮太,黒木 喜美子,渡邊 紘士,前仲 勝実
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-23K24012
  • [Presentation] 免疫チェックポイント阻害可能な抗 HLA-G 抗体の機能評価2023

    • Author(s)
      下柿元咲瑛、黒木喜美子、引地和馬、赤岩愛記、古川敦、前田直良、荒瀬尚、前仲勝実
    • Organizer
      日本生化学会北海道支部第60回支部例会
    • Data Source
      KAKENHI-PROJECT-23K24012
  • [Presentation] Novel receptor search for HLA-G2 and evaluation of their binding properties and functions2023

    • Author(s)
      Hiroshi Watanabe, Kimiko Kuroki, Katsumi Maenaka
    • Organizer
      第23回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-23K24012
  • [Presentation] 腫瘍免疫活性化を目指したHLA-G抗体スクリーニング2023

    • Author(s)
      下柿元咲瑛、黒木喜美子、引地和馬、赤岩愛記、古川敦、前田直良、前仲勝実
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-23K24012
  • [Presentation] 全身性エリテマトーデスモデルマウスにおけるHLA-G2蛋白質の発症抑制効果の検証2021

    • Author(s)
      渡邊 紘士、黒木 喜美子、山田 千聖、佐分利 由香里、高橋 愛実、前田 直良、前仲 勝実
    • Organizer
      第141回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-18K06073
  • [Presentation] Immunosuppressive effects of HLA-G2 protein in SLE model mice2020

    • Author(s)
      Hiroshi Watanabe, Kimiko Kuroki, Chisato Yamada, Yukari Saburi, Naoyoshi Maeda, Katsumi Maenaka
    • Organizer
      第20回日本蛋白質科学会年会
    • Data Source
      KAKENHI-PROJECT-18K06073
  • [Presentation] Immunosuppressive function of HLA-G2 protein in vivo2019

    • Author(s)
      Hiroshi Watanabe, Kimiko Kuroki, Chisato Yamada, Yukari Saburi, Naoyoshi Maeda, Katsumi Maenaka
    • Organizer
      第48回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K06073
  • [Presentation] 多様な免疫抑制タンパク質HLA-Gの機能・構造解析2018

    • Author(s)
      黒木喜美子
    • Organizer
      日本組織適合性学会
    • Data Source
      KAKENHI-PROJECT-18K06073
  • [Presentation] The effect of human HLA-G2/G6 isoform proteins.2015

    • Author(s)
      Ami Takahashi, Kimiko Kuroki, Katsumi Maenaka
    • Organizer
      日本生物物理学会北海道支部例会
    • Place of Presentation
      札幌
    • Year and Date
      2015-03-15
    • Data Source
      KAKENHI-PROJECT-25870019
  • [Presentation] The immunosuppressive effect of non-covalent dimer of HLA-G domain deletion type in collagen-induced arthritis mice.2014

    • Author(s)
      Ami Takahashi, Kimiko Kuroki, Katsumi Maenaka
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10
    • Data Source
      KAKENHI-PROJECT-25870019
  • [Presentation] Three dimensional reconstruction of HLA-G2/G6 isoform2013

    • Author(s)
      Kazuhiro Mio, Kimiko Kuroki, Haruki Matsubara, Yoshiyuki Kasai, Sachie Manaka, Chikara Sato, Katsumi Maenaka
    • Organizer
      7th International Conference on Structural Genomics(ICSG2013-SLS)
    • Place of Presentation
      KEIO PLAZA HOTEL SAPPORO, Sapporo
    • Data Source
      KAKENHI-PROJECT-25870019
  • [Presentation] ヒト免疫制御受容体LILRB1とリガンドHLA-Gの複合体の結晶構造解析2012

    • Author(s)
      黒木喜美子
    • Organizer
      分子生物学会
    • Place of Presentation
      福岡・福岡国際会議場・マリンメッセ福岡
    • Data Source
      KAKENHI-PROJECT-23770102
  • [Presentation] Structural basis for recognition of nonclassical MHC molecule HLA-G by the LILRB12012

    • Author(s)
      Kimiko Kuroki
    • Organizer
      The 10th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      The Alumni Hall "Frate", Graduate School of Medicine, Hokkaido University
    • Data Source
      KAKENHI-PROJECT-23770102
  • [Presentation] Immunosuppressive effects of treatment with HLA-G dimer in collagen-induced mouse arthritis2012

    • Author(s)
      Kimiko Kuroki
    • Organizer
      6th International conference on HLA-G
    • Place of Presentation
      Paris, Fondation Del Duca
    • Data Source
      KAKENHI-PROJECT-23770102
  • [Presentation] 免疫抑制分子HLA-Gダイマーの局所投与による関節炎抑制効果の検討2011

    • Author(s)
      黒木喜美子
    • Organizer
      分子生物学会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23770102
  • 1.  喜多 俊介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  加藤 晃一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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