Kuroki Kimiko 黒木喜美子

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KUROKI Kimiko 黒木喜美子

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Researcher Number	90553313
Other IDs
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Affiliation (Current)	2025: 北海道大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 北海道大学, 薬学研究院, 教授 2022 – 2023: 北海道大学, 薬学研究院, 准教授 2018 – 2020: 北海道大学, 薬学研究院, 准教授 2011 – 2014: 北海道大学, 薬学研究科(研究院), 助教 2011 – 2012: 北海道大学, 大学院・薬学研究院, 助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Biological Sciences / Basic Section 43020:Structural biochemistry-related / Functional biochemistry / Structural biochemistry
Keywords	Principal Investigator LILR / 構造解析 / HLA-G / 免疫チェックポイント / 抗体 / 相互作用解析 / ホモ二量体 / HLA-G6 / 強直性脊椎炎 / HLA-B27 … More / アイソフォーム / 抗体医薬品 / 免疫抑制 / 免疫寛容 / 立体構造解析 / バイオ医薬品 / ANGPTL2 / HLA-G2 / LILRB2 / 抗炎症効果 / PIR-B / CIAマウス / 表面プラスモン共鳴法 / 電子顕微鏡解析 / 化合物スクリーニング / NMR / 電子顕微鏡 / X線結晶構造解析 Less

免疫抑制分子HLA-Gの機能理解・制御を目指した機能性抗体開発Principal Investigator
- Principal Investigator
  
  黒木喜美子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Hokkaido University
免疫抑制分子HLA-Gアイソフォームを特異的に機能阻害する腫瘍治療抗体医薬品開発Principal Investigator
- Principal Investigator
  
  黒木喜美子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Hokkaido University
Molecular recognition of immune inhibitory receptor, LILRB2, with HLA-G2 and various ligandsPrincipal Investigator
- Principal Investigator
  
  Kuroki Kimiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Hokkaido University
強直性脊椎炎病因蛋白質HLA-B27の受容体LILRB2を介した発症機構の解明Principal Investigator
- Principal Investigator
  
  黒木喜美子
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Structural analysis of HLA-G6 isoform bound to LILRB2 receptorPrincipal Investigator
- Principal Investigator
  
  KUROKI KIMIKO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
強直性脊椎炎病因蛋白質ＨＬＡ－Ｂ２７ホモ二量体の立体構造解析Principal Investigator
- Principal Investigator
  
  黒木喜美子
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Molecular recognition of HLA-G6 isoform with LILR familyPrincipal Investigator
- Principal Investigator
  
  KUROKI Kimiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Hokkaido University

All 2024 2023 2021 2020 2019 2018 2015 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Efficient preparation of human and mouse CD1d proteins using silkworm baculovirus expression system2020
- Author(s)
  Kusaka Hiroki、Kita Shunsuke、Tadokoro Takashi、Yoshida Kouki、Kasai Yoshiyuki、Niiyama Harumi、Fujimoto Yukari、Hanashima Shinya、Murata Michio、Sugiyama Shigeru、Ose Toyoyuki、Kuroki Kimiko、Maenaka Katsumi
- Journal Title
  
  Protein Expression and Purification
  
  Volume: 172 Pages: 105631-105631
- DOI
  10.1016/j.pep.2020.105631
- NAID
  120007147244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16051, KAKENHI-PROJECT-17K07296, KAKENHI-PROJECT-20K06529, KAKENHI-PROJECT-18KK0194, KAKENHI-PUBLICLY-19H04634, KAKENHI-PROJECT-18K06073, KAKENHI-PUBLICLY-19H04815, KAKENHI-PROJECT-19H00918
[Journal Article] Therapeutic effects of soluble human leukocyte antigen G2 isoform in lupus-prone MRL/lpr mice2020
- Author(s)
  Watanabe Hiroshi、Kuroki Kimiko、Yamada Chisato、Saburi Yukari、Maeda Naoyoshi、Maenaka Katsumi
- Journal Title
  
  Human Immunology
  
  Volume: 81 Issue: 4 Pages: 186-190
- DOI
  10.1016/j.humimm.2019.11.002
- NAID
  120007034052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06073, KAKENHI-PROJECT-17K08848, KAKENHI-PROJECT-20K07523
[Journal Article] Evaluation of the Reactivity and Receptor Competition of HLA-G Isoforms toward Available Antibodies: Implications of Structural Characteristics of HLA-G Isoforms2019
- Author(s)
  Furukawa Atsushi、Meguro Manami、Yamazaki Rika、Watanabe Hiroshi、Takahashi Ami、Kuroki Kimiko、Maenaka Katsumi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 23 Pages: 5947-5947
- DOI
  10.3390/ijms20235947
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06073, KAKENHI-PROJECT-18K14633
[Journal Article] Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms2019
- Author(s)
  Kuroki Kimiko、Matsubara Haruki、Kanda Ryo、Miyashita Naoyuki、Shiroishi Mitsunori、Fukunaga Yuko、Kamishikiryo Jun、Fukunaga Atsushi、Fukuhara Hideo、Hirose Kaoru、Hunt Joan S.、Sugita Yuji、Kita Shunsuke、Ose Toyoyuki、Maenaka Katsumi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 203 Issue: 12 Pages: 3386-3394
- DOI
  10.4049/jimmunol.1900562
- NAID
  120007018379
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06073, KAKENHI-PROJECT-19K06514, KAKENHI-PROJECT-18KK0194, KAKENHI-PROJECT-19H00918, KAKENHI-PROJECT-17K07296, KAKENHI-PUBLICLY-19H04634
[Journal Article] The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.2013
- Author(s)
  Kuroki Kら
- Journal Title
  
  Hum Immunol.
  
  Volume: 74 Issue: 4 Pages: 433-438
- DOI
  10.1016/j.humimm.2012.11.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370043, KAKENHI-PROJECT-23770102, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-25709080
[Journal Article] Structural and functional mosaic nature of MHC class I molecules in their peptide-free form.2013
- Author(s)
  E.Kurimoto, K.Kuroki, Y.Yamaguchi, M.Yagi-Utsumi, T.Igaki, T.Iguchi, K.Maenaka, and K.Kato
- Journal Title
  
  Mol. Immunol.
  
  Volume: 55 Issue: 3-4 Pages: 393-399
- DOI
  10.1016/j.molimm.2013.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20107004, KAKENHI-PROJECT-23770102, KAKENHI-PROJECT-23870043
[Journal Article] Molecular recognition of paired receptors in the immune system.2012
- Author(s)
  Kuroki K, et al.
- Journal Title
  
  Front Microbiol.
  
  Volume: 3 Pages: 429-429
- DOI
  10.3389/fmicb.2012.00429
- Data Source
  KAKENHI-PUBLICLY-23133501
[Journal Article] Analysis of receptor-ligand interactions by surface plasmon resonance2011
- Author(s)
  Kuroki K, Maenaka K
- Journal Title
  
  Methods Mol Biol
  
  Volume: 748 Pages: 83-106
- DOI
  10.1007/978-1-61779-139-0_6
- ISBN
  9781617791383, 9781617791390
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23133501
[Journal Article] Molecular basis for LLT1 recognition by human CD161 (NKRP1A/KLRB1)2011
- Author(s)
  Kamishikiryo, ら
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Issue: 27 Pages: 23823-23830
- DOI
  10.1074/jbc.m110.214254
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22121007, KAKENHI-PROJECT-23770102
[Journal Article] Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT2011
- Author(s)
  Rieko Kojima, et al
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 413(4) Issue: 4 Pages: 762-772
- DOI
  10.1016/j.jmb.2011.09.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03326, KAKENHI-PLANNED-22121007, KAKENHI-PROJECT-22370043, KAKENHI-PROJECT-23770102
[Presentation] Immunoregulatory mechanisms mediated by a novel receptor for the immunosuppressive protein HLA-G22024
- Author(s)
  Hiroshi Watanabe, Kimiko Kuroki, Katsumi Maenaka
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24012
[Presentation] 免疫抑制蛋白質製剤としての開発に向けたHLA-G2の発現系の検討2023
- Author(s)
  山本亮太，黒木喜美子，渡邊紘士，前仲勝実
- Organizer
  日本薬学会北海道支部第150回例会
- Data Source
  KAKENHI-PROJECT-23K24012
[Presentation] 免疫抑制分子HLA-G2のバイオ医薬品開発に向けた哺乳細胞発現系の検討2023
- Author(s)
  山本亮太，黒木喜美子，渡邊紘士，前仲勝実
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-23K24012
[Presentation] 免疫チェックポイント阻害可能な抗 HLA-G 抗体の機能評価2023
- Author(s)
  下柿元咲瑛、黒木喜美子、引地和馬、赤岩愛記、古川敦、前田直良、荒瀬尚、前仲勝実
- Organizer
  日本生化学会北海道支部第６０回支部例会
- Data Source
  KAKENHI-PROJECT-23K24012
[Presentation] Novel receptor search for HLA-G2 and evaluation of their binding properties and functions2023
- Author(s)
  Hiroshi Watanabe, Kimiko Kuroki, Katsumi Maenaka
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K24012
[Presentation] 腫瘍免疫活性化を目指したHLA-G抗体スクリーニング2023
- Author(s)
  下柿元咲瑛、黒木喜美子、引地和馬、赤岩愛記、古川敦、前田直良、前仲勝実
- Organizer
  日本薬学会　第143年会
- Data Source
  KAKENHI-PROJECT-23K24012
[Presentation] 全身性エリテマトーデスモデルマウスにおけるHLA-G2蛋白質の発症抑制効果の検証2021
- Author(s)
  渡邊紘士、黒木喜美子、山田千聖、佐分利由香里、高橋愛実、前田直良、前仲勝実
- Organizer
  第141回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-18K06073
[Presentation] Immunosuppressive effects of HLA-G2 protein in SLE model mice2020
- Author(s)
  Hiroshi Watanabe, Kimiko Kuroki, Chisato Yamada, Yukari Saburi, Naoyoshi Maeda, Katsumi Maenaka
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K06073
[Presentation] Immunosuppressive function of HLA-G2 protein in vivo2019
- Author(s)
  Hiroshi Watanabe, Kimiko Kuroki, Chisato Yamada, Yukari Saburi, Naoyoshi Maeda, Katsumi Maenaka
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06073
[Presentation] 多様な免疫抑制タンパク質HLA-Gの機能・構造解析2018
- Author(s)
  黒木喜美子
- Organizer
  日本組織適合性学会
- Data Source
  KAKENHI-PROJECT-18K06073
[Presentation] The effect of human HLA-G2/G6 isoform proteins.2015
- Author(s)
  Ami Takahashi, Kimiko Kuroki, Katsumi Maenaka
- Organizer
  日本生物物理学会北海道支部例会
- Place of Presentation
  札幌
- Year and Date
  2015-03-15
- Data Source
  KAKENHI-PROJECT-25870019
[Presentation] The immunosuppressive effect of non-covalent dimer of HLA-G domain deletion type in collagen-induced arthritis mice.2014
- Author(s)
  Ami Takahashi, Kimiko Kuroki, Katsumi Maenaka
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-25870019
[Presentation] Three dimensional reconstruction of HLA-G2/G6 isoform2013
- Author(s)
  Kazuhiro Mio, Kimiko Kuroki, Haruki Matsubara, Yoshiyuki Kasai, Sachie Manaka, Chikara Sato, Katsumi Maenaka
- Organizer
  7th International Conference on Structural Genomics(ICSG2013-SLS)
- Place of Presentation
  KEIO PLAZA HOTEL SAPPORO, Sapporo
- Data Source
  KAKENHI-PROJECT-25870019
[Presentation] ヒト免疫制御受容体LILRB1とリガンドHLA-Gの複合体の結晶構造解析2012
- Author(s)
  黒木喜美子
- Organizer
  分子生物学会
- Place of Presentation
  福岡・福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23770102
[Presentation] Structural basis for recognition of nonclassical MHC molecule HLA-G by the LILRB12012
- Author(s)
  Kimiko Kuroki
- Organizer
  The 10th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  The Alumni Hall "Frate", Graduate School of Medicine, Hokkaido University
- Data Source
  KAKENHI-PROJECT-23770102
[Presentation] Immunosuppressive effects of treatment with HLA-G dimer in collagen-induced mouse arthritis2012
- Author(s)
  Kimiko Kuroki
- Organizer
  6th International conference on HLA-G
- Place of Presentation
  Paris, Fondation Del Duca
- Data Source
  KAKENHI-PROJECT-23770102
[Presentation] 免疫抑制分子HLA-Gダイマーの局所投与による関節炎抑制効果の検討2011
- Author(s)
  黒木喜美子
- Organizer
  分子生物学会
- Place of Presentation
  横浜・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23770102

1. 喜多俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 加藤晃一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuroki Kimiko 黒木 喜美子

KUROKI Kimiko 黒木 喜美子

Research Projects

Research Products

Co-Researchers

免疫抑制分子HLA-Gの機能理解・制御を目指した機能性抗体開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫抑制分子HLA-Gアイソフォームを特異的に機能阻害する腫瘍治療抗体医薬品開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular recognition of immune inhibitory receptor, LILRB2, with HLA-G2 and various ligandsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

強直性脊椎炎病因蛋白質HLA-B27の受容体LILRB2を介した発症機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural analysis of HLA-G6 isoform bound to LILRB2 receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

強直性脊椎炎病因蛋白質ＨＬＡ－Ｂ２７ホモ二量体の立体構造解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular recognition of HLA-G6 isoform with LILR familyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Efficient preparation of human and mouse CD1d proteins using silkworm baculovirus expression system2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Therapeutic effects of soluble human leukocyte antigen G2 isoform in lupus-prone MRL/lpr mice2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Evaluation of the Reactivity and Receptor Competition of HLA-G Isoforms toward Available Antibodies: Implications of Structural Characteristics of HLA-G Isoforms2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural and functional mosaic nature of MHC class I molecules in their peptide-free form.2013

Author(s)

Journal Title

DOI

Data Source

Kuroki Kimiko 黒木喜美子

KUROKI Kimiko 黒木喜美子