Harada Hiroaki 原田洋明

… Alternative Names

原田洋明ハラダヒロアキ

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Researcher Number	90573816
Affiliation (Current)	2025: 独立行政法人国立病院機構東広島医療センター(臨床研究部), 診療部呼吸器外科, 呼吸器外科医師
Affiliation (based on the past Project Information) *help	2021: 独立行政法人国立病院機構東広島医療センター(臨床研究部), 診療部呼吸器外科, 呼吸器外科医師 2017 – 2019: 独立行政法人国立病院機構東広島医療センター(臨床研究部), 診療部呼吸器外科, 呼吸器外科医師 2016: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他(移行) 2014 – 2015: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他
Review Section/Research Field	Principal Investigator Respiratory surgery / Basic Section 55040:Respiratory surgery-related
Keywords	Principal Investigator 肺癌 / 遺伝子異常 / 肺がん / エピジェネティクス / 分子標的 / エピゲノム / 外科 / バイオマーカー / 口腔粘膜 / 分子マーカー … More / 遺伝子メチル化異常 / リスク因子 / メチレーション / 予後因子 / 早期発見 / メチル化 / 分子生物学的マーカー / 手術 Less

肺癌における原発病巣と転移・再発病巣間の異質性メカニズムの解析Principal Investigator
- Principal Investigator
  
  原田洋明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Higashihiroshima Medical Center
Establishment of a model for risk stratification of lung cancer development by comprehensive analysis of oral mucosal gene abnormalitiesPrincipal Investigator
- Principal Investigator
  
  Harada Hiroaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Higashihiroshima Medical Center
Novel strategy for lung cancer risk stratification through the assessment of epigenetic alteration in oral eputheliumPrincipal Investigator
- Principal Investigator
  
  Harada Hiroaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Department of Clinical Research, National Hospital Organization Kure Medical Center

All 2021 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Lung cancer risk stratification using methylation profile in the oral epithelium2019
- Author(s)
  Hiroaki Harada, et al.
- Journal Title
  
  Asian Cardiovasucular and Thoracic Annals
  
  Volume: 27 Issue: 2 Pages: 87-92
- DOI
  10.1177/0218492318813443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10807
[Journal Article] The Role of DNA Methylation as a Biomarker in Lung Cancer: Prognostic Prediction and Early Detection.2016
- Author(s)
  Harada H, Miyamoto K, KuwaharaM, YamashitaY.
- Journal Title
  
  Advances in Modern Medicine During the Last Decade
  
  Volume: １ Pages: 66-72
- DOI
  10.2174/9781681080239117010010
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462143
[Journal Article] Prognostic signature of protocadherin 10 methylation in curatively resected pathological stage I non-small-cell lung cancer.2015
- Author(s)
  11. Harada H, Miyamoto K, Yamashita Y, Taniyama K, Mihara K, Nishimura M, Okada M.
- Journal Title
  
  Cancer Medicine
  
  Volume: 4 Issue: 10 Pages: 1536-1546
- DOI
  10.1002/cam4.507
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462143
[Journal Article] Methylated DLX4 Predicts Response to Pathologic Stage I Non-Small Cell Lung Cancer Resection2015
- Author(s)
  Hiroaki Harada, Kazuaki Miyamoto, Yoshinori Yamashita, Kiyomi Taniyama, Hideki Ohdan, Morihito Okada
- Journal Title
  
  Annals of Thoracic Surgery
  
  Volume: 99 Issue: 5 Pages: 1746-1756
- DOI
  10.1016/j.athoracsur.2014.12.058
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462143
[Presentation] Assessment of inter-lobe biological diversity in the lung by DNA methylation profiles in autopsy cases2021
- Author(s)
  Hiroaki Harada
- Organizer
  25th Congress of the Asian Pacific Society of Respirology
- Data Source
  KAKENHI-PROJECT-21K08895
[Presentation] Evaluation of the inter-tumor heterogeneity of PD-L1 expression in primary and metastatic lesions of autopsy cases with untreated lung adenocarcinoma2021
- Author(s)
  Hiroaki Harada
- Organizer
  25th Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08895
[Presentation] 肺癌無治療例における剖検検体を用いた病巣別p16エピジェネティクス異常プロファイルの検討2019
- Author(s)
  原田洋明、他
- Organizer
  第60回　日本肺癌学会総会
- Data Source
  KAKENHI-PROJECT-17K10807
[Presentation] Assessment of inter-tumor heterogeneity among primary and metastatic lesions in a patient with untreated lung cancer by DNA methylation profiling: an autopsy case2019
- Author(s)
  Hiroaki Harada, et al.
- Organizer
  24th Congres of the Asian PacifiSociety of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10807
[Presentation] 口腔粘膜遺伝子エピジェネティクス異常解析による肺癌発生リスク層別化の試み2019
- Author(s)
  原田洋明、他
- Organizer
  第36回　日本呼吸器外科学会　学術総会
- Data Source
  KAKENHI-PROJECT-17K10807
[Presentation] Clinical relevance between preoperative serum oxidative stress level and aberrant DNA methylation of peripheral whole blood in patients with curatively resected Stage I lung adenocarcinoma; A pilot analysis.2018
- Author(s)
  Narumi Yashiki, Hiroaki Harada, et al
- Organizer
  23rd Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10807
[Presentation] Clinical implication of DNA methylation analysis in the oral epithelium for lung cancer risk stratification2018
- Author(s)
  Hiroaki Harada, et al.
- Organizer
  23rd Congress of the Asian Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10807
[Presentation] Preoperative serum oxidative stress levels are associated with aberrant PCDH10 methylation in serum and poor clinical outcomes in curatively resected node-negative non-small cell lung cancer2017
- Author(s)
  Hiroaki Harada, et al.
- Organizer
  Asia Pacific Society of Respirology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10807
[Presentation] Combined Analysis of Epigenetic Inactivation of MDFI, DLX4, and PCDH10 in Stage I Non-Small Cell Lung Cancer for the Assessment of Prognostic Impact2017
- Author(s)
  Hiroaki Harada, et al.
- Organizer
  World Congress of Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10807
[Presentation] 口腔粘膜遺伝子エピジェネティクス異常を用いた肺癌発生リスク評価の試み2017
- Author(s)
  原田洋明　他
- Organizer
  日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10807
[Presentation] Combined analyses of DNA methylation profiling in oral epithelium for lung cancer risk stratification2016
- Author(s)
  Hiroaki Harada, Kazuaki Miyamoto, Yoshinori Yamashita, Norifumi Tsubokawa, Kazuko Mihara, Morihito Okada, Kiyomi Taniyama
- Organizer
  27th Rajavithi Hospital Annual Academic Meeting
- Place of Presentation
  Bangkok
- Year and Date
  2016-02-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462143
[Presentation] HOXD methylation status in the oral epithelium is a promising biomarker for lung cancer risk stratification2015
- Author(s)
  Hiroaki Harada, Kazuaki Miyamoto, Yoshinori Yamashita, Norifumi Tsubokawa, Morihito Okada
- Organizer
  20th Congress of Asian Pacific Society of Respirology
- Place of Presentation
  Kuala Lumpur
- Year and Date
  2015-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462143
[Presentation] Epigenetic Inactivation of MDFI Predicts Poor Recurrence-Free Survival after Complete Resection of Pathologic Stage I Non-Small Cell Lung Cancer2015
- Author(s)
  Hiroaki Harada, Kazuaki Miyamoto, Yoshinori Yamashita, Norifumi Tsubokawa, Morihito Okada
- Organizer
  20th Congress of Asian Pacific Society of Respirology
- Place of Presentation
  Kuala Lumpur
- Year and Date
  2015-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462143
[Presentation] Prognostic Value of the Protocadherin 10 Promoter Methylation Status in Curatively Resected Pathological Stage I Non-small Cell Lung Cancer
- Author(s)
  Hiroaki Harada, Kazuaki Miyamoto, Yoshinori Yamashita, Kiyomi Taniyama, Morihito Okada
- Organizer
  The Society of Thoracic Surgeons 51^st Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-01-24 – 2015-01-28
- Data Source
  KAKENHI-PROJECT-26462143

1. OKADA Morihito (70446045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. KIMURA Masami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Harada Hiroaki 原田 洋明

原田 洋明 ハラダ ヒロアキ

Research Projects

Research Products

Co-Researchers

肺癌における原発病巣と転移・再発病巣間の異質性メカニズムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a model for risk stratification of lung cancer development by comprehensive analysis of oral mucosal gene abnormalitiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel strategy for lung cancer risk stratification through the assessment of epigenetic alteration in oral eputheliumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lung cancer risk stratification using methylation profile in the oral epithelium2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Role of DNA Methylation as a Biomarker in Lung Cancer: Prognostic Prediction and Early Detection.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic signature of protocadherin 10 methylation in curatively resected pathological stage I non-small-cell lung cancer.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Methylated DLX4 Predicts Response to Pathologic Stage I Non-Small Cell Lung Cancer Resection2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Assessment of inter-lobe biological diversity in the lung by DNA methylation profiles in autopsy cases2021

Author(s)

Organizer

Data Source

[Presentation] Evaluation of the inter-tumor heterogeneity of PD-L1 expression in primary and metastatic lesions of autopsy cases with untreated lung adenocarcinoma2021

Author(s)

Organizer

Data Source

[Presentation] 肺癌無治療例における剖検検体を用いた病巣別p16エピジェネティクス異常プロファイルの検討2019

Author(s)

Organizer

Data Source

[Presentation] Assessment of inter-tumor heterogeneity among primary and metastatic lesions in a patient with untreated lung cancer by DNA methylation profiling: an autopsy case2019

Author(s)

Organizer

Data Source

[Presentation] 口腔粘膜遺伝子エピジェネティクス異常解析による肺癌発生リスク層別化の試み2019

Author(s)

Organizer

Data Source

[Presentation] Clinical relevance between preoperative serum oxidative stress level and aberrant DNA methylation of peripheral whole blood in patients with curatively resected Stage I lung adenocarcinoma; A pilot analysis.2018

Author(s)

Organizer

Data Source

[Presentation] Clinical implication of DNA methylation analysis in the oral epithelium for lung cancer risk stratification2018

Author(s)

Organizer

Data Source

[Presentation] Preoperative serum oxidative stress levels are associated with aberrant PCDH10 methylation in serum and poor clinical outcomes in curatively resected node-negative non-small cell lung cancer2017

Author(s)

Organizer

Data Source

[Presentation] Combined Analysis of Epigenetic Inactivation of MDFI, DLX4, and PCDH10 in Stage I Non-Small Cell Lung Cancer for the Assessment of Prognostic Impact2017

Author(s)

Organizer

Data Source

[Presentation] 口腔粘膜遺伝子エピジェネティクス異常を用いた肺癌発生リスク評価の試み2017

Harada Hiroaki 原田洋明

原田洋明ハラダヒロアキ