Yamamoto Naoki 山本直樹

… Alternative Names

山本直樹ヤマモトナオキ

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Researcher Number	90580671
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 自治医科大学, 医学部, 講師 2022 – 2023: 自治医科大学, 医学部, 講師 2018 – 2020: 自治医科大学, 医学部, 助教 2019: 神戸大学, 理学研究科, 特命助教 2016 – 2017: 神戸大学, 理学研究科, 特命助教
Review Section/Research Field	Principal Investigator Basic Section 13040:Biophysics, chemical physics and soft matter physics-related / Biological physics/Chemical physics/Soft matter physics Except Principal Investigator Biophysics
Keywords	Principal Investigator テラヘルツ時間領域分光 / 回転緩和 / 線維前駆中間体 / アミロイド線維 / タンパク質の水和水 / 広帯域誘電分光 / アミロイド線維中間体 / 単粒子解析 / クライオ電子顕微鏡 / アミロイド中間体 … More / サブTHz領域 / テラヘルツ時間領域分光計 / タンパク質と水和水のダイナミクス / 低振動運動 / ベクトルネットワークアナライザ / テラヘルツ分光 / 水和水回転緩和 / タンパク質機能活性化 / 水和水 / タンパク質ダイナミクス / ダイナミクスと機能の相関 / 中性子散乱 / タンパク質水和 / 水和ダイナミクス / タンパク質 / 生物物理 / 動力学転移 / 水和タンパク質のダイナミクス / 誘電緩和 … More Except Principal Investigator 伝播 / 中間体 / アミロイド / ミスフォールディング / 蛋白質 Less

プロトフィブリルを標的とした抗アルツハイマー病薬剤の作用機序解明Principal Investigator
- Principal Investigator
  
  山本直樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
- Research Institution
  Jichi Medical University
Structural basis of the structural development of amyloid fibrils via the prefibrillar intermediates revealed by cryo-electron microscopyPrincipal Investigator
- Principal Investigator
  
  山本直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
- Research Institution
  Jichi Medical University
Spectroscopic Study on Protein Functionally-Relevant Modes Excited by Dynamics of Hydration WaterPrincipal Investigator
- Principal Investigator
  
  Yamamoto Naoki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
- Research Institution
  Jichi Medical University
Structural basis of propagation ability and toxicity of amyloid fibrils as elucidated through the analysis of prefibrillar intermediates
- Principal Investigator
  
  CHATANI Eri
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Kobe University
Understanding hydraiton-water dynamics related to amyloid fibril formationPrincipal Investigator
- Principal Investigator
  
  Yamamoto Naoki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological physics/Chemical physics/Soft matter physics
- Research Institution
  Kobe University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Tracking the Structural Development of Amyloid Precursors in the Insulin B Chain and the Inhibition Effect by Fibrinogen2022
- Author(s)
  Naoki Yamamoto, Rintaro Inoue, Yoshiteru Makino, Hiroshi Sekiguchi, Naoya Shibayama, Akira Naito, Masaaki Sugiyama, and Eri Chatani
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 126 Issue: 51 Pages: 10797-10812
- DOI
  10.1021/acs.jpcb.2c05136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K03555, KAKENHI-PROJECT-19KK0071, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-20H03224, KAKENHI-PROJECT-20K06579, KAKENHI-PROJECT-20K21396, KAKENHI-PLANNED-18H05534
[Journal Article] Freezable and Unfreezable Hydration Water: Distinct Contributions to Protein Dynamics Revealed by Neutron Scattering2021
- Author(s)
  Yamamoto Naoki、Kofu Maiko、Nakajima Kenji、Nakagawa Hiroshi、Shibayama Naoya
- Journal Title
  
  The Journal of Physical Chemistry Letters
  
  Volume: 12 Issue: 8 Pages: 2172-2176
- DOI
  10.1021/acs.jpclett.0c03786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06601, KAKENHI-PROJECT-20H02944, KAKENHI-PROJECT-18K03559
[Journal Article] Structural Insights into the Inhibition of Amyloid Fibril Formation by Fibrinogen via Interaction with Prefibrillar Intermediates2019
- Author(s)
  Yamamoto Naoki、Akai Taiki、Inoue Rintaro、Sugiyama Masaaki、Tamura Atsuo、Chatani Eri
- Journal Title
  
  Biochemistry
  
  Volume: 58 Issue: 24 Pages: 2769-2781
- DOI
  10.1021/acs.biochem.9b00439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0071, KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-18H05229, KAKENHI-PROJECT-16H04778, KAKENHI-PROJECT-17K07361
[Journal Article] Effect of temperature and hydration level on purple membrane dynamics studied using broadband dielectric spectroscopy from sub-GHz to THz regions2018
- Author(s)
  Naoki Yamamoto, Shota Ito, Masahiro Nakanishi, Eri Chatani, Keiichi Inoue, Hideki Kandori, Keisuke Tominaga
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 122 Issue: 4 Pages: 1367-1377
- DOI
  10.1021/acs.jpcb.7b10077
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H00772, KAKENHI-PLANNED-25104009, KAKENHI-PROJECT-15H02391, KAKENHI-PROJECT-16H04778, KAKENHI-PROJECT-17H03007, KAKENHI-PROJECT-16K17783
[Journal Article] A specific form of prefibrillar aggregates that functions as a precursor of amyloid nucleation2018
- Author(s)
  Naoki Yamamoto, Shoko Tsuhara, Atsuo Tamura, Eri Chatani
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 62-62
- DOI
  10.1038/s41598-017-18390-y
- NAID
  120006394632
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H00772, KAKENHI-PROJECT-16H04778, KAKENHI-PROJECT-15K13289, KAKENHI-PROJECT-16K17783
[Journal Article] Recent progress on understanding the mechanisms of amyloid nucleation2018
- Author(s)
  Eri Chatani, Naoki Yamamoto
- Journal Title
  
  Biophys. Rev.
  
  Volume: 10 Issue: 2 Pages: 527-534
- DOI
  10.1007/s12551-017-0353-8
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H00772, KAKENHI-PROJECT-16K17783, KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-16H04778
[Journal Article] Broadband Dielectric Spectroscopy on Lysozyme in the sub-Gigahertz to Terahertz Frequency Regions: Effects of Hydration and Thermal Excitation2016
- Author(s)
  Naoki Yamamoto, Kaoru Ohta, Atsuo Tamura,　 Keisuke Tominaga
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 120 Issue: 21 Pages: 4743-4755
- DOI
  10.1021/acs.jpcb.6b01491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26288079, KAKENHI-PROJECT-15K13289, KAKENHI-PROJECT-16K17783
[Presentation] 電子顕微鏡を用いたアミロイド線維中間体の構造発達追跡2023
- Author(s)
  山本直樹
- Organizer
  第２３回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-22K03555
[Presentation] Electron Microscopy of Amyloid Fibril Structures2023
- Author(s)
  Naoki Yamamoto
- Organizer
  The 61st Annual Meeting of the Biophysical Society of Japan
- Data Source
  KAKENHI-PROJECT-22K03555
[Presentation] 広帯域誘電分光によるタンパク質水和水ダイナミクスの評価2020
- Author(s)
  山本直樹
- Organizer
  分子フォト研究会　「誘電応答から見るソフトマターの水和ダイナミクス」
- Invited
- Data Source
  KAKENHI-PROJECT-18K03559
[Presentation] X線小角散乱によるアミロイド線維前駆中間体発達の時分割追跡2020
- Author(s)
  山本直樹;赤井大気;井上倫太郎;杉山正明;柴山直哉;茶谷絵理
- Organizer
  京都大学原子炉実験所第54回学術講演会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] アミロイド核形成メカニズムの解明を目指した核形成中間体の捕捉と構造解析2020
- Author(s)
  吉川祐樹;山本直樹;井上倫太郎;守島健;杉山正明;田村厚夫;茶谷絵理
- Organizer
  京都大学原子炉実験所第54回学術講演会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Protein hydration dynamics probed by broadband dielectric spectroscopy and neutron scattering2020
- Author(s)
  Naoki Yamamoto
- Organizer
  Dynamics of Chemical and Biological Systems, IIT Kampur
- Invited
- Data Source
  KAKENHI-PROJECT-18K03559
[Presentation] Enhanced membrane disruption by Aβ1-40 under weak acidic conditions2019
- Author(s)
  Kaori Mageshi;Naoki Yamamoto;Ryota Komatsu;Kenichi Morigaki;Masatomo So;Yuji Goto;Eri Chatani
- Organizer
  Ulm Meeting on “Biophysics of Amyloid Formation”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Examination of the possibility of the formation of transmissible transthyretin amyloid fibrils by the use of proteolysis2019
- Author(s)
  Misato Matsumura;Naoki Yamamoto;Keiichi Yamaguchi;Masatomo So;Yuji Goto;Eri Chatani
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Iodine staining for identifying amyloid polymorphism and for tracking seed-dependent structural propagation2019
- Author(s)
  Eri Chatani;Takato Hiramatsu;Keisuke Yuzu;Naoki Yamamoto;Mitsuru Yasuda;Mika Ishigaki;Yukihiro Ozaki
- Organizer
  Indo-Japan Workshop-Frontiers in Molecular Spectroscopy: From Fundamentals to Applications in Chemistry and Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] アミロイドβ線維認識に関与するNLRP3-LRRドメインの構造特徴および認識機構の解明2019
- Author(s)
  政安梨緒;山本良太;今村比呂志;山本直樹;松花沙織;井上邦夫;鍔木基成;茶谷絵理
- Organizer
  非共有結合系の分子科学：計測技術から探る生体分子科学の新展開/研究プロジェクト「非共有結合系分子科学研究」
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] トランスサイレチンのアミロイド線維形成に対するプロテアーゼの効果2019
- Author(s)
  松村美里;山本直樹;山口圭一;宗正智;後藤祐児;茶谷絵理
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Structural characterization of amyloid nucleation intermediates of insulin B chain2019
- Author(s)
  Yuhki Yoshikawa;Naoki Yamamoto;Atsuo Tamura;Eri Chatani
- Organizer
  非共有結合系の分子科学：計測技術から探る生体分子科学の新展開/研究プロジェクト「非共有結合系分子科学研究」
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Protein hydration water dynamics probed by broadband dielectric spectroscopy2019
- Author(s)
  Naoki Yamamoto
- Organizer
  International Conference on Chemical and Environmental Sciences 2019, Kolkata
- Invited
- Data Source
  KAKENHI-PROJECT-18K03559
[Presentation] temperature and hydration dependence of protein dynamics studied by broadband dielectric spectroscopy and neutron scattering2019
- Author(s)
  Naoki Yamamoto
- Organizer
  Indo-Japan workshop, 2019, Kobe, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-18K03559
[Presentation] アミロイド核形成メカニズムの解明を目指した核形成中間体の捕捉と構造解析2019
- Author(s)
  吉川祐樹;山本直樹;井上倫太郎;杉山正明;田村厚夫;茶谷絵理
- Organizer
  神戸大学第10回サイエンスフロンティア研究発表会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 広帯域誘電分光を用いたタンパク質水和水のダイナミクス観測2019
- Author(s)
  山本直樹
- Organizer
  テラヘルツ分光で水を研究する会
- Invited
- Data Source
  KAKENHI-PROJECT-18K03559
[Presentation] アミロイドβ線維認識に関わるNLRP3-LRRドメインの構造特徴と認識機構の研究2019
- Author(s)
  政安梨緒;山本良太;今村比呂志;山本直樹;松花沙織;井上邦夫;鍔木基成;茶谷絵理
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Iodine staining as a useful probe for amyloid polymorphism and its propagation2019
- Author(s)
  Eri Chatani;Takato Hiramatsu;Keisuke Yuzu;Naoki Yamamoto
- Organizer
  第57回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] アミロイド核形成機構の解明を目指した核形成中間体の捕捉と構造解析2019
- Author(s)
  吉川祐樹;山本直樹;田村厚夫;茶谷絵理
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] プロテアーゼがトランスサイレチンのアミロイド線維形成に与える効果の検証2019
- Author(s)
  松村美里;山本直樹;山口圭一;宗正智;後藤祐児;茶谷絵理
- Organizer
  神戸大学研究基盤センター若手フロンティア研究会2019
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] トランスサイレチンのアミロイド線維化に対するプロテアーゼの効果2019
- Author(s)
  松村美里;山本直樹;茶谷絵理
- Organizer
  非共有結合系の分子科学：計測技術から探る生体分子科学の新展開/研究プロジェクト「非共有結合系分子科学研究」
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] フィブリノーゲンによるインスリンB鎖アミロイド線維の形成阻害2019
- Author(s)
  茶谷絵理;山本直樹;赤井大気;井上倫太郎;杉山正明;田村厚夫
- Organizer
  京都大学複合原子力科学研究所第53回学術講演会プログラム
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] ヨウ素染色で見るアミロイド線維構造の多様性と伝播様式2019
- Author(s)
  茶谷絵理;平松貴人;柚佳祐;山本直樹
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Observation of prefibrillar intermediates of insulin B chain and their stabilization by interaction with fibrinogen2019
- Author(s)
  Eri Chatani;Naoki Yamamoto;Taiki Akai;Shoko Tsuhara;Atsuo Tamura;Rintaro Inoue;Masaaki Sugiyama
- Organizer
  Towards a Cure for Amyloid Siseases: A Successful Example of Precision and Translational Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 広帯域誘電分光による水和タンパク質ダイナミクスの評価2019
- Author(s)
  山本直樹
- Organizer
  東京大学　物性研究所極限コヒーレント光科学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K03559
[Presentation] 様々なpHにおけるインスリンB鎖のアミロイド核形成反応中間体の観察2018
- Author(s)
  吉川祐樹;山本直樹;田村厚夫;茶谷絵理
- Organizer
  第18回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] NLRP3におけるLRRドメインの構造特徴およびアミロイドβ線維認識機構の解明2018
- Author(s)
  政安梨緒;山本良太;今村比呂志;山本直樹;鍔木基成;茶谷絵理
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 炎症誘起タンパク質NLRP3のLRRドメインによるアミロイドβ線維の直接的認識2018
- Author(s)
  政安梨緒;山本良太;今村比呂志;山本直樹;松花沙織;井上邦夫;鍔木基成;茶谷絵理
- Organizer
  神戸大学研究基盤センター若手フロンティア研究会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] タンパク質の広帯域誘電分光；水和水ダイナミクスおよびその熱活性の検証2018
- Author(s)
  山本直樹;伊藤奨太;太田薫;中西真大;田村厚夫;井上圭一;神取秀樹;茶谷絵理;富永圭介
- Organizer
  第18回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 弱酸性条件におけるAβ1-40のアミロイド線維形成と脂質膜破壊2018
- Author(s)
  曲師香緒里;山本直樹;森垣憲一;茶谷絵理
- Organizer
  第18回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Characterization and Stabilization of Prefibrillar Aggregate of Insulin B Chain for Inhibition of Amyloid Fibril Formation2018
- Author(s)
  Naoki Yamamoto, Taiki Akai, Shoko Tsuhara, Atsuo Tamura, Rintaro Inoue, Masaaki Sugiyama, Eri Chatani
- Organizer
  新学術領域研究「動的秩序と機能」第６回国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] Broadband dielectric spectroscopy on hydrated proteins2018
- Author(s)
  Naoki Yamamoto, Shota Ito, Kaoru Ohta, Masahiro Nakanishi, Atsuo Tamura, Eri Chatani, Hideki Kandori, Keisuke Tominaga
- Organizer
  Symposium on Advanced Spectroscopic Techniques, University of the Philippines Los Banos
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K03559
[Presentation] Broadband dielectric spectroscopy on proteins and lipid bilayers from sub-GHz to THz2018
- Author(s)
  Naoki Yamamoto, Yu Kadomura, Shota Ito, Masahiro Nakanishi, Eri Chatani, Kei-ichi Inoue, Hideki Kandori, Keisuke Tominaga
- Organizer
  13th DAE-BRNS Biennial Trombay Symposium onRadiation & Photochemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Investigation of multi-step nucleation of insulin B chain amyloid fibrils and its inhibition2018
- Author(s)
  Naoki Yamamoto;Taiki Akai;Shoko Tsuhara;Rintaro Inoue;Masaaki Sugiyama;Atsuo Tamura;Eri Chatani
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Temperature and Hydration Dependence of Protein Dynamics Studied by Broadband Dielectric Spectroscopy2018
- Author(s)
  Naoki Yamamoto
- Organizer
  FIR center seminar, Fukui University
- Invited
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] Structural comparison of amyloid nucleation intermediates of insulin B chain formed at different pHs2018
- Author(s)
  Yuhki Yoshikawa;Naoki Yamamoto;Atsuo Tamura;Eri Chatani
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] アミロイド核形成メカニズムの解明を目指した核形成中間体の捕捉および構造解析2018
- Author(s)
  吉川祐樹;山本直樹;田村厚夫;茶谷絵理
- Organizer
  神戸大学研究基盤センター若手フロンティア研究会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 細胞のアミロイドβ線維認識に関わるNLRP3-LRRドメインの構造特徴の解明2018
- Author(s)
  政安梨緒;山本良太;今村比呂志;山本直樹;鍔木基成;茶谷絵理
- Organizer
  第18回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Characterization and stabilization of prefibrillar aggregate of insulin B chain for inhibition of amyloid fibril formation2018
- Author(s)
  Naoki Yamamoto, Taiki Akai, Shoko Tsuhara, Atsuo Tamura, Rintaro Inoue, Masaaki Sugiyama, Eri Chatani
- Organizer
  新学術領域「動的秩序と機能」第6回国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] タンパク質の広帯域誘電分光；水和水ダイナミクスおよびその熱活性の検証2018
- Author(s)
  山本直樹
- Organizer
  第１８回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] Broadband dielectric spectroscopy on proteins from sub-GHz to THz regions2018
- Author(s)
  Naoki Yamamoto
- Organizer
  Indo-Japan mini-workshop -Frontiers in Molecular Spectroscopy: From Fundamentals to Applications in Chemistry and Biology-、Kobe University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K03559
[Presentation] Exploring the mechanisms of protein self-assembly underlying amyloid nuclei formation2018
- Author(s)
  Eri Chatani, Naoki Yamamoto
- Organizer
  新学術領域「動的秩序と機能」第6回国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Characterization of Prefibrillar Aggregates that Function as a Precursor of Amyloid Nucleation2017
- Author(s)
  Naoki Yamamoto, Shoko Tsuhara, Atsuo Tamura, Eri Chatani
- Organizer
  The 55th Annual Meeting of the Biophysical Society of Japan
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] A New fibrinogen function of trapping amyloid intermediate conformation2017
- Author(s)
  Taiki Akai, Naoki Yamamoto, Eri Chatani
- Organizer
  新学術領域「動的秩序と機能」第5回国際シンポジウム
- Place of Presentation
  東京大学駒場キャンパス（東京都・目黒区）
- Year and Date
  2017-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Investigation of inhibition mechanism of fibrinogen in the amyloid fibrillation2017
- Author(s)
  赤井大気, 山本直樹, 茶谷絵理
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Characterization of prefibillar intermediates that function as a precursorof the amyloid fibrils2017
- Author(s)
  Naoki Yamamoto, Shoko Tsuhara, Atsuo Tamura, Eri Chatani
- Organizer
  Horizon in Molecular Biology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Induction of the amyloid fibril formation by an ultrasonic wave on the prefibrillar intermediate of insulin B chain2017
- Author(s)
  Naoki Yamamoto, Shoko Tsuhara, Atsuo Tamura, Eri Chatani
- Organizer
  The 17th Annual Meeting of the Protein Science Society of Japan
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] 弱酸性条件におけるAβ1-40のアミロイド線維形成と膜破壊機構の解明2017
- Author(s)
  曲師香緒里, 山本直樹, 平松貴人, 茶谷絵理
- Organizer
  第4回新学術領域研究「動的秩序と機能」若手研究会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Aβ1-40のアミロイド線維形成と膜破壊能に対するpHの効果2017
- Author(s)
  曲師香緒里, 山本直樹, 平松貴人, 茶谷絵理
- Organizer
  若手フロンティア研究会2017
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 弱酸性条件におけるAβ1-40アミロイド線維形成反応の観察2017
- Author(s)
  曲師香緒里, 平松貴人, 山本直樹, 茶谷絵理
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] pHおよび塩濃度に依存したトランスサイレチン凝集反応の観察2017
- Author(s)
  下地恭平, 山本直樹, 茶谷絵理
- Organizer
  第4回新学術領域研究「動的秩序と機能」若手研究会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Role of prefibrillar intermediates of insulin B chain in its amyloid fibril formation2017
- Author(s)
  Naoki Yamamoto, Shoko Tsuhara, Atsuo Tamura, Eri Chatani
- Organizer
  新学術領域「動的秩序と機能」第5回国際シンポジウム
- Place of Presentation
  東京大学駒場キャンパス（東京都・目黒区）
- Year and Date
  2017-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] A specific form of prefibrillar aggregates that functions as a precursor of amyloid nucleation2017
- Author(s)
  山本直樹, 津原祥子, 田村厚夫, 茶谷絵理
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Nucleation dynamics in amyloid formation as investigated by the analysis of prefibrillar intermediates2017
- Author(s)
  Eri Chatani, Naoki Yamamoto
- Organizer
  新学術領域「動的秩序と機能」第5回国際シンポジウム
- Place of Presentation
  東京大学駒場キャンパス（東京都・目黒区）
- Year and Date
  2017-01-22
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] トランスサイレチン凝集反応のpH および塩濃度依存性の解析2017
- Author(s)
  下地恭平, 山本直樹, 茶谷絵理
- Organizer
  若手フロンティア研究会2017
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 超音波照射によるインスリンB 鎖アミロイド前駆中間体の線維化誘導2017
- Author(s)
  山本直樹, 津原祥子, 田村厚夫, 茶谷絵理
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Characterization of prefibillar intermediates that function as a precursorof the amyloid fibrils2017
- Author(s)
  Naoki Yamamoto, Shoko Tsuhara, Atsuo Tamura, Eri Chatani
- Organizer
  The 14th Horizons in Molecular Biology Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] Amyloid fibrillation of Aβ1-40 under weak acidic conditions2017
- Author(s)
  曲師香緒里, 山本直樹, 平松貴人, 茶谷絵理
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Protein hydration and its thermal excitation studied by broadband dielectric spectroscopy2017
- Author(s)
  Naoki Yamamoto, Shota Ito, Eri Chatani, Hideki Kandori, Keisuke Tominaga
- Organizer
  The 1st Philippine-Japan Terahertz Research Workshop
- Place of Presentation
  De La sale University Science and Technology Complex, the Philippines
- Year and Date
  2017-02-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] 広帯域誘電武功を用いた紫膜ダイナミクスの観測；サブGHz-THz領域における水和および温度依存性の評価2016
- Author(s)
  山本直樹、伊藤奨太、茶谷絵理、神取秀樹、富永圭介
- Organizer
  第10回分子科学討論会
- Place of Presentation
  神戸ファッションマート
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] 様々な炎症物質を認識するNLRP3-LRRドメインの発現系の確立とその構造的基盤の解明2016
- Author(s)
  山本良太、山下和人、今村比呂志、鍔木基成、茶谷絵理
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Protein hydration dynamics studied by broadband dielectric spectroscopy2016
- Author(s)
  Naoki Yamamoto, Shota Ito, Kaoru Ohta, Atsuo Tamura, Eri Chatani, Hideki Kandori, Keisuke Tominaga
- Organizer
  Japan-Taiwan Medical Spectroscopy International Symposium
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県・淡路市）
- Year and Date
  2016-12-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 広帯域誘電分光で観るタンパク質ダイナミクスの水和および熱励起効果2016
- Author(s)
  山本直樹
- Organizer
  テラヘルツテクノロジーフォーラム　平成28年度　第1回技術セミナー
- Place of Presentation
  ホテル北野プラザ六甲荘
- Year and Date
  2016-10-26
- Invited
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] 広帯域誘電分光を用いた紫膜のダイナミクスにおける温度および水和依存性の観測2016
- Author(s)
  山本直樹、伊藤奨太、茶谷絵理、神取秀樹、富永圭介
- Organizer
  第43回生体分子科学討論会
- Place of Presentation
  名古屋大学
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] 一残基アミノ酸挿入によるアミロイドβタンパク質の線維形成機構の解明2016
- Author(s)
  山下和人、山本直樹、鍔木基成、茶谷絵理
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] アミロイド線維形成に対するフィブリノーゲンの共存効果2016
- Author(s)
  赤井大気、山本直樹、茶谷絵理
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Investigation of molecular basis underlying the recognition of various inflammatory substances by NLRP3-LRR domain2016
- Author(s)
  山本良太、山下和人、今村比呂志、鍔木基成、茶谷絵理
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Fibrinogen inhibits amyloid fibrillation by stopping at the stage of intermediates2016
- Author(s)
  赤井大気、山本直樹、茶谷絵理
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 線維前駆中間体を経由したアミロイド線維形成機構　－インスリン B 鎖が形成する初期会合体のキャラクタリゼーション－2016
- Author(s)
  山本直樹、津原祥子、田村厚夫、茶谷絵理
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Effects of hydration on protein dynamics and its thermal excitation studied by broadband dielectric spectroscopy2016
- Author(s)
  Naoki Yamamoto, Shota Ito, Eri Chatani, Hideki Kandori, Keisuke Tominaga
- Organizer
  2nd International Aquaphotomics Symposium
- Place of Presentation
  Kobe University
- Year and Date
  2016-11-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] Investigation of protein aggregation processes leading to amyloid formation2016
- Author(s)
  Eri Chatani, Naoki Yamamoto
- Organizer
  Japan-Taiwan Medical Spectroscopy International Symposium
- Place of Presentation
  淡路夢舞台国際会議場（兵庫県・淡路市）
- Year and Date
  2016-12-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 広帯域誘電分光法を用いた紫膜のダイナミクスにおける温度および水和依存性の観測2016
- Author(s)
  山本直樹、伊藤奨太、茶谷絵理、神取秀樹、富永圭介
- Organizer
  第43回生体分子科学討論会2016
- Place of Presentation
  名古屋大学野依記念学術交流館（愛知県・名古屋市）
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 広帯域誘電分光を用いた紫膜ダイナミクスの観測；サブGHz-THz領域における水和および温度依存性の評価2016
- Author(s)
  山本直樹、伊藤奨太、茶谷絵理、神取秀樹、富永圭介
- Organizer
  第10回分子科学討論会
- Place of Presentation
  神戸ファッションマート（兵庫県・神戸市）
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] THz分光および広帯域誘電分光による水和タンパク質ダイナミクスの観測2016
- Author(s)
  山本直樹
- Organizer
  Spring-8シンポジウム　放射光赤外研究会サテライトミーティング　「振動分光でわかること：赤外分光の今後と方向性」
- Place of Presentation
  関西学院大学神戸三田キャンパス
- Year and Date
  2016-08-20
- Invited
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] 線維前駆中間体に作用点をもつフィブリノーゲンのアミロイド線維化阻害機構2016
- Author(s)
  赤井大気、山本直樹、茶谷絵理
- Organizer
  新学術領域研究「動的秩序と機能」第３回若手研究会
- Place of Presentation
  加賀観光ホテル（石川県・加賀市）
- Year and Date
  2016-10-12
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Hydration and thermal-excitation effects of purple membrane dynamics probed by broadband dielectric spectroscopy2016
- Author(s)
  Naoki Yamamoto, Shota Ito, Eri Chatani, Hideki Kandori, Keisuke Tominaga
- Organizer
  Indo-Japan Discussion Meeting on Frontiers in Molecular Spectroscopy: From Fundamental to Applications on material science and biology
- Place of Presentation
  Indian Institute of Technology Kanpur, India
- Year and Date
  2016-11-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] Molecular exploration of prefibrillar intermediates that lead to formation of amyloid fibrils2016
- Author(s)
  Eri Chatani, Naoki Yamamoto
- Organizer
  Indo-Japan Joint Seminar on "Frontiers in Molecular Spectroscopy: From Fundamentals to Applications on Material Science and Biology"
- Place of Presentation
  Indian Institute of Technology, Kanpur (Kanpur, India)
- Year and Date
  2016-11-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Effects of hydration and thermal excitation of globular and membrane proteins studied by broadband dielectric spectroscopy2016
- Author(s)
  山本　直樹、伊藤　奨太、茶谷　絵理、神取　秀樹、富永　圭介
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] 広帯域分光による水/ジメチルスルホキシド二成分液体中におけるタンパク質の構造安定性2016
- Author(s)
  飯沼美紀、山本直樹、太田薫、茶谷絵理、富永圭介
- Organizer
  第10回分子科学討論会
- Place of Presentation
  神戸ファッションマート（兵庫県・神戸市）
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Effects of hydration on protein dynamics and its thermal excitation studied by broadband dielectric spectroscopy2016
- Author(s)
  Naoki Yamamoto, Shota Ito, Hideki Kandori, Kaoru Ohta, Atsuo Tamura, Eri Chatani, Keisuke Tominaga
- Organizer
  AQUAPHOTOMICS: UNDERSTANDING WATER in BIOLOGY 2nd INTERNATIONAL SYMPOSIUM
- Place of Presentation
  神戸大学（兵庫県・神戸市）
- Year and Date
  2016-11-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778
[Presentation] Protein hydration dynamics studied by broadband dielectric spectroscopy2016
- Author(s)
  Naoki Yamamoto, Shota Ito, Kaoru Ohta, Atsuo Tamura, Eri Chatani, Hideki Kandori, Keisuke Tominaga
- Organizer
  Japan-Taiwan Medical Spectroscopy International Symposium
- Place of Presentation
  Awaji Yumebutai International Conference Center
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] Effects of hydration and thermal excitation of globular and membrane proteins studied by broadband dielectric spectroscopy2016
- Author(s)
  山本直樹、伊藤奨太、茶谷絵理、神取秀樹、富永圭介
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  筑波国際会議場
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16K17783
[Presentation] Hydration and thermal-excitation effects of purple membrane dynamics probed by broadband dielectric spectroscopy2016
- Author(s)
  Naoki Yamamoto, Shota Ito, Eri Chatani, Hideki Kandori, Keisuke Tominaga
- Organizer
  Indo-Japan Joint Seminar on "Frontiers in Molecular Spectroscopy: From Fundamentals to Applications on Material Science and Biology"
- Place of Presentation
  Indian Institute of Technology, Kanpur (Kanpur, India)
- Year and Date
  2016-11-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04778

1. CHATANI Eri (00432493)

# of Collaborated Projects: 2 results

# of Collaborated Products: 72 results
2. TOMINAGA Keisuke (30202203)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. NAKANISHI Masahiko (00707763)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. INOUE Rintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 杉山正明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 柴山修哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 田村厚夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamamoto Naoki 山本 直樹

山本 直樹 ヤマモト ナオキ

Research Projects

Research Products

Co-Researchers

プロトフィブリルを標的とした抗アルツハイマー病薬剤の作用機序解明Principal Investigator

Principal Investigator

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Structural basis of the structural development of amyloid fibrils via the prefibrillar intermediates revealed by cryo-electron microscopyPrincipal Investigator

Principal Investigator

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Review Section

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Spectroscopic Study on Protein Functionally-Relevant Modes Excited by Dynamics of Hydration WaterPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Structural basis of propagation ability and toxicity of amyloid fibrils as elucidated through the analysis of prefibrillar intermediates

Principal Investigator

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Research Institution

Understanding hydraiton-water dynamics related to amyloid fibril formationPrincipal Investigator

Principal Investigator

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Research Institution

[Journal Article] Tracking the Structural Development of Amyloid Precursors in the Insulin B Chain and the Inhibition Effect by Fibrinogen2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Freezable and Unfreezable Hydration Water: Distinct Contributions to Protein Dynamics Revealed by Neutron Scattering2021

Author(s)

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DOI

Data Source

[Journal Article] Structural Insights into the Inhibition of Amyloid Fibril Formation by Fibrinogen via Interaction with Prefibrillar Intermediates2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of temperature and hydration level on purple membrane dynamics studied using broadband dielectric spectroscopy from sub-GHz to THz regions2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A specific form of prefibrillar aggregates that functions as a precursor of amyloid nucleation2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Recent progress on understanding the mechanisms of amyloid nucleation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Broadband Dielectric Spectroscopy on Lysozyme in the sub-Gigahertz to Terahertz Frequency Regions: Effects of Hydration and Thermal Excitation2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 電子顕微鏡を用いたアミロイド線維中間体の構造発達追跡2023

Author(s)

Organizer

Data Source

[Presentation] Electron Microscopy of Amyloid Fibril Structures2023

Author(s)

Organizer

Data Source

[Presentation] 広帯域誘電分光によるタンパク質水和水ダイナミクスの評価2020

Yamamoto Naoki 山本直樹

山本直樹ヤマモトナオキ