ITO Tomokazu 伊藤智和

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Ito Tomokazu 伊藤智和

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Researcher Number	90584970
Other IDs
Affiliation (Current)	2025: 名古屋大学, 生命農学研究科, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 名古屋大学, 生命農学研究科, 准教授 2016 – 2023: 名古屋大学, 生命農学研究科, 講師 2010 – 2014: 名古屋大学, 生命農学研究科, 助教
Review Section/Research Field	Principal Investigator Applied biochemistry / Basic Section 38030:Applied biochemistry-related Except Principal Investigator Basic Section 38020:Applied microbiology-related / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator D-セリンデヒドラターゼ / D-アミノ酸 / D-セリン / ピリドキサールリン酸 / D-アスパラギン酸 / 補酵素 / 代謝 / ビタミン / 葉酸 / 恒常性 … More / ビタミンＢ6 / アミノ酸 / ピリドキサールレダクターゼ / PLPBP / YggS/PROSC / ピリドキシンリン酸 / ビタミンB6 / 腎機能 / セリンラセマーゼ / バイオマーカー / D-セリンデヒドラーゼ / ピリドキサール / ピリドキサール5'リン酸 … More Except Principal Investigator 大腸菌 / 古細菌 / イソプレノイド / メバロン酸経路 / アミノ酸 / 発酵生産 / 脂質代謝 / インスリン抵抗性 Less

アミノ酸代謝フロー変化による脂肪蓄積メカニズムの解明
- Principal Investigator
  
  北浦靖之
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Chubu University
「修飾型」葉酸の生物分布と分子機能の解明Principal Investigator
- Principal Investigator
  
  伊藤智和
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Nagoya University
Effective fermentative production of isoprenoid via oxygen-tolerant archaeal mevalonate pathway
- Principal Investigator
  
  邊見久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Nagoya University
肥満・インスリン抵抗性におけるアミノ酸代謝フロー変化の解明とその応用
- Principal Investigator
  
  北浦靖之
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Nagoya University
Creation of microbial cells as the innovative chassis for isoprenoid production
- Principal Investigator
  
  Hemmi Hisashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  Nagoya University
Elucidation of the function of a conserved pyridoxal phosphate-binding protein involved in the homeostasis of amino acid metabolismPrincipal Investigator
- Principal Investigator
  
  Ito Tomokazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Applied biochemistry
- Research Institution
  Nagoya University
D-amino acid biological system in eukaryotePrincipal Investigator
- Principal Investigator
  
  Ito Tomokazu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Nagoya University
Function and regulation of D-amino acid in eukaryotePrincipal Investigator
- Principal Investigator
  
  ITO Tomokazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Nagoya University
Functions and metabolism of D-serine in eukaryotePrincipal Investigator
- Principal Investigator
  
  ITO Tomokazu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Applied biochemistry
- Research Institution
  Nagoya University

[Journal Article] d‐amino acid auxotrophic Escherichia coli strain for in vivo functional cloning of novel d‐amino acid synthetic enzyme2023
- Author(s)
  Ito Tomokazu、Muto Natsumi、Sakagami Haruna、Tanaka Miho、Hemmi Hisashi、Yoshimura Tohru
- Journal Title
  
  The FEBS Journal
  
  Volume: 290 Issue: 11 Pages: 2895-2908
- DOI
  10.1111/febs.16734
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H02899
[Journal Article] A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway2023
- Author(s)
  Komeyama Mutsumi、Kanno Kohsuke、Mino Hiroyuki、Yasuno Yoko、Shinada Tetsuro、Ito Tomokazu、Hemmi Hisashi
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 14 Pages: 1150353-1150353
- DOI
  10.3389/fmicb.2023.1150353
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H02899, KAKENHI-PROJECT-21K14629, KAKENHI-PUBLICLY-23H04560
[Journal Article] Identification and functional analysis of a new type of Z,E-mixed prenyl reductase from mycobacteria2022
- Author(s)
  Abe, T., Hakamata, M., Nishiyama, A., Tateishi, Y., Matsumoto, S., Hemmi, H., Ueda, D., and Sato, T.
- Journal Title
  
  The FEBS journal
  
  Volume: - Issue: 16 Pages: 4981-4997
- DOI
  10.1111/febs.16412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21J14050, KAKENHI-PROJECT-21K19637, KAKENHI-PROJECT-20KK0216, KAKENHI-PROJECT-20H02899, KAKENHI-PROJECT-23K24374
[Journal Article] Mechanism of pyridoxine 5'-phosphate accumulation in pyridoxal 5'-phosohate-binding protein-deficiency2022
- Author(s)
  Ito, T., Ogawa, H., Hemmi, H., Downs, D. M., & Yoshimura, T.
- Journal Title
  
  Jornal of Bacteriology
  
  Volume: 204 Issue: 3
- DOI
  10.1128/jb.00521-21
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H02882, KAKENHI-PROJECT-20H02899
[Journal Article] Identification and characterization of a serine racemase in the silkworm Bombyx mori2022
- Author(s)
  Tanaka Yui、Yoshimura Tohru、Hakamata Maho、Saito Chiaki、Sumitani Megumi、Sezutsu Hideki、Hemmi Hisashi、Ito Tomokazu
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 172 Issue: 1 Pages: 17-28
- DOI
  10.1093/jb/mvac026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H02899
[Journal Article] Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways2022
- Author(s)
  Aoki Mizuki、Vinokur Jeffrey、Motoyama Kento、Ishikawa Rino、Collazo Michael、Cascio Duilio、Sawaya Michael R.、Ito Tomokazu、Bowie James U.、Hemmi Hisashi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 7 Pages: 102111-102111
- DOI
  10.1016/j.jbc.2022.102111
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H02899
[Journal Article] Urinary L-erythro-β-hydroxyasparagine - a novel serine racemase inhibitor and substrate of the Zn2+-dependent D-serine dehydratase2021
- Author(s)
  Ito T., Tono M., Kitaura Y., Hemmi H., Yoshimura T
- Journal Title
  
  Bioscience Reports
  
  Volume: 41 Issue: 4
- DOI
  10.1042/bsr20210260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H02882, KAKENHI-PROJECT-20H02899
[Journal Article] Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway2021
- Author(s)
  Yasuno Yoko、Nakayama Atsushi、Saito Kai、Kitsuwa Kohei、Okamura Hironori、Komeyama Mutsumi、Hemmi Hisashi、Shinada Tetsuro
- Journal Title
  
  Journal of Natural Products
  
  Volume: 84 Issue: 10 Pages: 2749-2754
- DOI
  10.1021/acs.jnatprod.1c00615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K14629, KAKENHI-PROJECT-20K06939, KAKENHI-PROJECT-20H02899
[Journal Article] Isopentenyl diphosphate/dimethylallyl diphosphate-specific Nudix hydrolase from the methanogenic archaeon Methanosarcina mazei2021
- Author(s)
  Ishibashi Yumi、Matsushima Natsumi、Ito Tomokazu、Hemmi Hisashi
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 86 Issue: 2 Pages: 246-253
- DOI
  10.1093/bbb/zbab205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H02899
[Journal Article] Inhibition of glycine cleavage system by pyridoxine 5′‐phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli2020
- Author(s)
  Ito Tomokazu、Hori Ran、Hemmi Hisashi、Downs Diana M.、Yoshimura Tohru
- Journal Title
  
  Molecular Microbiology
  
  Volume: 113 Issue: 1 Pages: 270-284
- DOI
  10.1111/mmi.14415
- NAID
  120006812139
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0153, KAKENHI-PROJECT-19H02882
[Journal Article] Pyridoxal reductase, PdxI, is critical for salvage of pyridoxal in Escherichia coli2020
- Author(s)
  Ito Tomokazu、Downs Diana M.
- Journal Title
  
  Journal of Bacteriology
  
  Volume: 202 Issue: 12
- DOI
  10.1128/jb.00056-20
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0153
[Journal Article] Mechanism of eukaryotic serine racemase-catalyzed serine dehydration2020
- Author(s)
  Ito Tomokazu、Matsuoka Mai、Goto Masaru、Watanabe Soichiro、Mizobuchi Taichi、Matsushita Kazuma、Nasu Ryoma、Hemmi Hisashi、Yoshimura Tohru
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: 1868 Issue: 9 Pages: 140460-140460
- DOI
  10.1016/j.bbapap.2020.140460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KK0153, KAKENHI-PROJECT-19H02882, KAKENHI-PROJECT-20H02899
[Journal Article] The Role of YggS in Vitamin B6 Homeostasis in Salmonella enterica Is Informed by Heterologous Expression of Yeast SNZ32020
- Author(s)
  Vu Huong N.、Ito Tomokazu、Downs Diana M.
- Journal Title
  
  Journal of Bacteriology
  
  Volume: 202 Issue: 22
- DOI
  10.1128/jb.00383-20
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0153
[Journal Article] Conserved Pyridoxal 5'-Phosphate Binding Protein YggS Impacts Amino Acid Metabolism through Pyridoxine 5'-Phosphate in Escherichia coli.2019
- Author(s)
  Ito T, Yamamoto K, Hori R, Yamauchi A, Downs DM, Hemmi H, Yoshimura T.
- Journal Title
  
  Appl Environ Microbiol.
  
  Volume: 11 Issue: 11
- DOI
  10.1128/aem.00430-19
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KK0153, KAKENHI-PROJECT-16H04908, KAKENHI-PROJECT-19H02882
[Journal Article] Production of Ophthalmic Acid Using Engineered Escherichia coli2018
- Author(s)
  Ito T, Tokoro M, Hori R, Hemmi H, Yoshimura T
- Journal Title
  
  Appl Environ Microbiol
  
  Volume: 84 Issue: 7 Pages: 02806-02817
- DOI
  10.1128/aem.02806-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18686, KAKENHI-PROJECT-16H04908
[Journal Article] Occurrence of the (2R,3S)-Isomer of 2-Amino-3,4-dihydroxybutanoic Acid in the Mushroom Hypsizygus marmoreus.2017
- Author(s)
  Ito T, Yu Z, Yoshino I, Hirozawa Y, Yamamoto K, Shinoda K, Watanabe A, Hemmi Ｈ, Asada Y, Yoshimura T.
- Journal Title
  
  J Agric Food Chem.
  
  Volume: 65 Issue: 30 Pages: 6131-6139
- DOI
  10.1021/acs.jafc.7b01893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18686, KAKENHI-PROJECT-16H04908
[Journal Article] Serine racemase is involved in D-aspartate biosynthesis.2016
- Author(s)
  Ito, T., Hayashida, M., Kobayashi, S., Muto, N., Hayashi, A., Yoshimura, T., Mori, H.
- Journal Title
  
  J Biochem.
  
  Volume: 160 Issue: 6 Pages: 345-353
- DOI
  10.1093/jb/mvw043
- NAID
  40021050460
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01279, KAKENHI-PROJECT-16K18686
[Journal Article] Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator2015
- Author(s)
  Okuda K., Kato S., Ito T., Shiraki S., Kawase Y., Goto M., Kawashima S., Hemmi H., Fukada H., Yoshimura T
- Journal Title
  
  Molecular Microbiology
  
  Volume: 95 Issue: 2 Pages: 245-257
- DOI
  10.1111/mmi.12861
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780098, KAKENHI-PROJECT-25292059
[Journal Article] Is D-aspartate produced by glutamic-oxaloacetic transaminase -1 like 1(Got1l1), a putative aspartate racemase?2015
- Author(s)
  Tanaka-Hayashi A, Hayashi S, Inoue R, Ito T, Konno K, Yoshida T, Watanabe M, Yoshimura T, Mori H
- Journal Title
  
  Amino Acids
  
  Volume: 47 Issue: 1 Pages: 79-86
- DOI
  10.1007/s00726-014-1847-3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24780098, KAKENHI-PUBLICLY-25110708, KAKENHI-PROJECT-25292059, KAKENHI-PROJECT-25293057, KAKENHI-PROJECT-26640038, KAKENHI-PROJECT-24220007, KAKENHI-PROJECT-25293059
[Journal Article] PEGylated D-Serine Dehydratase as a D-Serine Reucing Agent2015
- Author(s)
  Ito T., Takada H., Isobe K., Suzuki M., Kitaura Y., Hemmi H., Matsuda T., Sasabe J., Yoshimura T.
- Journal Title
  
  Journal of Parmacetuical and Biomedical Analysis
  
  Volume: in press Pages: 34-39
- DOI
  10.1016/j.jpba.2014.12.044
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24780098, KAKENHI-PROJECT-25292059
[Journal Article] Reaction mechanism of Zn2+-dependent D-serine dehydratase: role of a conserved tyrosine residue interacting with pyridine ring nitrogen of pyridoxal 5'-phosphate2014
- Author(s)
  Ito T., Matsuoka M., Koga K., Hemmi H., Yoshimura T.
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 156 Issue: 3 Pages: 173-180
- DOI
  10.1093/jb/mvu035
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24780098, KAKENHI-PROJECT-25292059
[Journal Article] D－アミノ酸代謝関連酵素ー構造・機能研究の最前線ー「D－セリンデヒドラターゼ」2014
- Author(s)
  伊藤智和
- Journal Title
  
  BIOINDUSTRY
  
  Volume: 3 Pages: 24-32
- Data Source
  KAKENHI-PROJECT-24780098
[Journal Article] Catalyticmechanism of serine racemase fromDictyostelium discoideum.2013
- Author(s)
  Ito T, Maekawa M, Hayashi S, Goto M,Hemmi H, Yoshimura T
- Journal Title
  
  Amino Acids
  
  Volume: 44 Issue: 3 Pages: 1073-1084
- DOI
  10.1007/s00726-012-1442-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380058, KAKENHI-PROJECT-24780098
[Journal Article] Conserved pyridoxal protein that regulates Ile and Val metabolism.2013
- Author(s)
  Ito T, Iimori J, Takayama S, Moriyama A, Yamauchi A, Hemmi H, Yoshimura T.
- Journal Title
  
  J Bacteriol.
  
  Volume: 195 Issue: 24 Pages: 5439-5449
- DOI
  10.1128/jb.00593-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24780098, KAKENHI-PROJECT-25292059
[Journal Article] Role of Zinc Ion for CatalyticActivity in D-Serine Dehydratase fromSaccharomyces cerevisiae2013
- Author(s)
  Ito T, Koga K, Hemmi H, YoshimuraT.
- Journal Title
  
  FEBS Journal
  
  Volume: 279 Issue: 4 Pages: 612-624
- DOI
  10.1111/j.1742-4658.2011.08451.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380058, KAKENHI-PROJECT-22880014
[Journal Article] Metal ion dependency of serine racemase from Dictyostelium discoideum2012
- Author(s)
  Ito T, Murase H, Maekawa M, Goto M, Hayashi S, Saito H, Maki M, Hemmi H, Yoshimura T
- Journal Title
  
  Amino Acids
  
  Volume: (印刷中) Issue: 4 Pages: 1567-1576
- DOI
  10.1007/s00726-012-1232-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380058, KAKENHI-PROJECT-22770113, KAKENHI-PROJECT-24780098
[Journal Article] Role of zinc ion for catalytic activity in D-serine dehydratase from Saccharomyces cerevisiae2012
- Author(s)
  Ito T, Koga K, Hemmi H, Yoshimura T
- Journal Title
  
  FEBS J.
  
  Volume: 279 Pages: 61-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22880014
[Journal Article] Metal ion dependency of serine racemase from Dictyostelium discoideum2012
- Author(s)
  Ito T, Murase H, Maekawa M, Goto M, Hayashi S, Saito H, Maki M, Hemmi H, Yoshimura T
- Journal Title
  
  Amino acids
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22880014
[Journal Article] ほ乳類のアスパラギン酸ラセマーゼ2011
- Author(s)
  伊藤智和、吉村徹
- Journal Title
  
  Vitamins
  
  Volume: 85 Pages: 661-662
- Data Source
  KAKENHI-PROJECT-22880014
[Journal Article] A highly sensitive enzymatic assay for D-and total serine detection using D-serine dehydratase from Saccharomyces cerevisiae2011
- Author(s)
  Naka T, Ito T, Hemmi H, Yoshimura T
- Journal Title
  
  J. Mol. Catal. B Enzymatic
  
  Volume: 67 Pages: 150-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22880014
[Journal Article] ほ乳動物のアスパラギン酸ラセマーゼ2011
- Author(s)
  伊藤智和、吉村徹
- Journal Title
  
  ビタミン
  
  Volume: 85 Pages: 661-662
- NAID
  110008898023
- Data Source
  KAKENHI-PROJECT-22880014
[Journal Article] A highly sensitive enzymatic assay for D- and total serine detection using D-serine dehydratase from Saccharomyces cerevisiae2010
- Author(s)
  Tomoko Naka, Tomokazu Ito, Hisashi Hemmi, Tohru Yoshimura
- Journal Title
  
  Journal of Molecular Catalysis B
  
  Volume: 67 Pages: 150-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22880014
[Journal Article] 右手型アミノ酸の役割2010
- Author(s)
  伊藤智和
- Journal Title
  
  生物工学会誌
  
  Volume: 88 Pages: 613-613
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 古細菌祖先型プレニル化フラビンモノヌクレオチド合成酵素の基質特異性2024
- Author(s)
  伊志嶺壮真, 星野洋輔, 伊藤智和, 邊見久
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K26819
[Presentation] テトラエーテル脂質合成酵素ホモログの機能および生成物特異性の解明2024
- Author(s)
  石原和華, 井深達哉, 伊藤智和, 浅川晋, 横川隆志, 邊見久
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-23K26819
[Presentation] メタン生成アーキアにおけるテトラエーテル脂質合成酵素の機能解析2023
- Author(s)
  石原和華, 井深達哉, 伊藤智和, 浅川晋, 横川隆志, 邊見久
- Organizer
  第33回イソプレノイド研究会例会
- Data Source
  KAKENHI-PROJECT-23K26819
[Presentation] 低酸素条件におけるイソプレノイド生産を強化する古細菌型メバロン酸経路2023
- Author(s)
  高橋拓矢、伊藤智和、邊見久
- Organizer
  2023年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] 大腸菌における新奇フォリルポリ-α-グルタミン酸合成酵素の同定と機能解析2023
- Author(s)
  小瀬有里奈、邊見久、伊藤智和
- Organizer
  2023年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] カイコセリンラセマーゼの同定と酵素学的性質の解析2022
- Author(s)
  田中優衣、伊藤智和、邊見久、吉村徹
- Organizer
  2022年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] 乳酸菌のD-アミノ酸トランスポーターの同定と性状解析2022
- Author(s)
  青木浩一郎，邊見久，伊藤智和
- Organizer
  第９５回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] 超好熱性古細菌Aeropyrum pernix由来ホスホメバロン酸脱水酵素の鉄硫黄クラスターに関する研究2022
- Author(s)
  菅野航佑、米山　睦、三野広幸、品田哲郎、保野陽子、伊藤智和、吉村　徹、邊見　久
- Organizer
  第３０回イソプレノイド研究会例会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] Escherichia coliにおけるピリドキシン5’-リン酸の脱リン酸化酵素の同定2022
- Author(s)
  松尾ひなの、邊見　久、吉村　徹、伊藤智和
- Organizer
  日本ビタミン学会第７４回大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] Picrophilus torridus由来3,5-ビスホスホメバロン酸デカルボキシラーゼにおける奇妙な活性制御2022
- Author(s)
  邊見　久、青木瑞希、本山賢人、石川りの、伊藤智和
- Organizer
  日本Archaea研究会第34回講演会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] ゲラニルゲラニル二リン酸による3,5-ビスホスホメバロン酸デカルボキシラーゼの活性制御2022
- Author(s)
  石川りの、青木瑞希、本山賢人、伊藤智和、邊見　久
- Organizer
  第９５回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] Escherichia coli におけるビタミンB6発酵生産法の開発2022
- Author(s)
  松尾ひなの，邊見久，吉村徹，伊藤智和
- Organizer
  第９５回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] アーキア型メバロン酸経路を用いた大腸菌のイソプレノイド生産能強化2022
- Author(s)
  高橋拓矢、吉田稜、伊藤智和、吉村徹、邊見久
- Organizer
  2022年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] 哺乳類のPLレダクターゼ同定に向けた取り組み2021
- Author(s)
  西山尚来、伊藤智和、邊見久、吉村徹
- Organizer
  2021年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] Escherichia coliにおけるビタミンB6脱リン酸化酵素の同定2021
- Author(s)
  松尾ひなの、伊藤智和、邊見久、吉村徹
- Organizer
  第９４回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] 哺乳類のPLレダクターゼ同定に向けた取り組み2021
- Author(s)
  西山尚来、伊藤智和、邊見久、吉村徹
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-17KK0153
[Presentation] アーキア型メバロン酸経路の鍵酵素であるホスホメバロン酸脱水酵素は[4Fe-4S]型鉄硫黄クラスターを有する2021
- Author(s)
  米山　睦、三野広幸、保野陽子、品田哲郎、伊藤智和、邊見　久
- Organizer
  日本Archaea研究会第33回講演会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] 哺乳類のピリドキサールレダクターゼ同定に向けた取り組み2021
- Author(s)
  西山尚来、伊藤智和、邊見　久、吉村　徹
- Organizer
  日本ビタミン学会第７３回大会
- Data Source
  KAKENHI-PROJECT-20H02899
[Presentation] D-アミノ酸生産酵素の新規in vivoスクリーニング法2020
- Author(s)
  伊藤智和、吉村徹
- Organizer
  日本分生生物学会2020年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0153
[Presentation] 高度に保存されたビタミン B6 結合タンパク質の機能解析と応用展開2020
- Author(s)
  伊藤智和
- Organizer
  日本農芸化学会2021年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0153
[Presentation] YggS/PROSCタンパク質ファミリーによるビタミンB6恒常性維持機構2020
- Author(s)
  小河ほのか、伊藤智和、邊見久、吉村徹
- Organizer
  日本農芸化学会 2020年度大会
- Data Source
  KAKENHI-PROJECT-17KK0153
[Presentation] YggS/PROSCタンパク質の欠損によるpyridoxine 5'-phosphate蓄積の要因2020
- Author(s)
  小河ほのか、伊藤智和、邊見久、吉村徹
- Organizer
  日本農芸化学会中部支部第187回支部例会
- Data Source
  KAKENHI-PROJECT-17KK0153
[Presentation] YggS/PROSCタンパク質ファミリーによるビタミンB6の恒常性維持機構2020
- Author(s)
  小河ほのか、伊藤智和、邊見久、吉村徹
- Organizer
  日本ビタミン学会第72回大会
- Data Source
  KAKENHI-PROJECT-17KK0153
[Presentation] アミノ酸・ビタミンB6恒常性に関与する新奇ビタミンB6結合タンパク質2020
- Author(s)
  伊藤智和
- Organizer
  日本ビタミン学会第７２回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17KK0153
[Presentation] YggS/PROSCファミリータンパク質のアミノ酸代謝制御機構の解析2019
- Author(s)
  山本佳奈、伊藤智和、邊見久、吉村徹
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17KK0153
[Presentation] E. coliビタミンB6結合タンパク質YggSの機能解明：glyAとの合成致死性の解析2018
- Author(s)
  堀　蘭、伊藤　智和、山内　綾子、吉村　徹、邊見　久
- Organizer
  2018年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] D-セリンデヒドラターゼの基質となるヒト尿中未知アミノ酸の同定2018
- Author(s)
  戸野真由香、伊藤智和、邊見久、吉村徹
- Organizer
  2018年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] D-アミノ酸合成酵素のファンクショナルクローニング系の開発2018
- Author(s)
  武藤　菜摘、伊藤　智和、吉村　徹、邊見　久
- Organizer
  2018年度日本農芸化学会大会
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] E.coliのPLP結合タンパク質YggSの生理機能：欠損株が示すホモセリン毒性の要因の解析2017
- Author(s)
  伊藤　智和、堀　蘭、山内　綾子、吉村　徹、邊見　久
- Organizer
  2017酵素・補酵素研究会
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] D-アミノ酸研究における代謝酵素の応用利用2017
- Author(s)
  伊藤　智和
- Organizer
  D-アミノ酸学会第三回ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] D-セリンデヒドラターゼの基質となるヒト尿中未知アミノ酸の同定2017
- Author(s)
  戸野真由香、伊藤智和、邊見久、吉村徹
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] 高度に保存された機能未知タンパク質の機能解析2017
- Author(s)
  伊藤　智和、吉村　徹
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] ブナシメジに存在する新奇D-アミノ酸の同定2017
- Author(s)
  伊藤智和・余卓尓・吉野一晴・渡邊彰・邊見久・麻田恭彦・吉村徹
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] Unusual D-Amino acids in mushroom2017
- Author(s)
  Tomokazu Ito, Zhuoer Yu, Issei Yoshino, Yurina Hirozawa, Kana Yamamoto, Akira Watanabe, Hisashi Hemmi, Yasuhiko Asada, Tohru Yoshimura
- Organizer
  International Conference of D-Amino Acid Research（IDAR2017）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] 哺乳類におけるD-アスパラギンサンの生合成機構と抗酸化作用の解析2016
- Author(s)
  武藤菜摘・伊藤智和・邊見久・川原幸一・吉村徹
- Organizer
  日本生化学会中部支部例会・シンポジウム
- Place of Presentation
  三重大学
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] ブナシメジに存在するユニークなD-アミノ酸の同定と生長過程における動態解析2016
- Author(s)
  伊藤智和・余卓尓・吉野一晴・渡邊彰・邊見久・麻田恭彦・吉村徹
- Organizer
  D-アミノ酸学会
- Place of Presentation
  高知大学
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-16K18686
[Presentation] 細胞性粘菌におけるD-セリン代謝酵素欠損の影響2014
- Author(s)
  伊藤智和、濱内菜月、邊見久、吉村徹
- Organizer
  2014年度日本農芸化学会大会
- Place of Presentation
  明治大学
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] D-SERINE METABOLISM IN CELLULAR SLIME MOLD AND EFFECTS OF D-SERINE DEHYDRATASE MUTATION2014
- Author(s)
  Tomokazu ITO, Natsuki HAMAUCHI, Hisashi HEMMI, Tamao SAITO, Tohru YOSHIMURA
- Organizer
  4th International Conference on Cofactors (ICC-04)
- Place of Presentation
  宇都宮市
- Year and Date
  2014-09-01
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] イソロイシン、バリン代謝系に関与する新奇ビタミンB6タンパク質2013
- Author(s)
  伊藤智和、飯盛淳平、邊見久、吉村徹
- Organizer
  日本ビタミン学会第65回大会
- Place of Presentation
  一橋大学・一橋講堂
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] ピリドキサル5’-リンに依存するBacillus subtilis の転写制御因子GabR2013
- Author(s)
  奥田啓太、深田はるみ、伊藤智和、後藤　勝、吉村　徹
- Organizer
  日本生物高分子学会2013年度大会
- Place of Presentation
  学校法人常翔学園教育施設「大阪センター」
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] 真核微生物におけるD-セリン：代謝酵素と生理的意義2013
- Author(s)
  伊藤智和
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] 真核生物型D-セリンデヒドラターゼの反応機構：PLPピリジン環窒素の相互作用残基Y203の役割2013
- Author(s)
  松岡舞、伊藤智和、邊見久、吉村徹
- Organizer
  酵素補酵素研究会
- Place of Presentation
  立命館大学
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] 亜鉛依存性D-セリンデヒドラターゼの反応機構：PLPピリジン環窒素の相互作用残基Y203の変異体解析2013
- Author(s)
  松岡舞、伊藤智和、古賀和志、邊見久、吉村徹
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] 細胞性粘菌におけるD-セリンデヒドラターゼ欠損の影響2013
- Author(s)
  濱内菜月、伊藤智和、邊見久、齊藤玉緒、吉村徹
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] D-アスパラギン酸合成酵素とされる哺乳動物Got1l1の酵素活性2013
- Author(s)
  林修平、伊藤智和、邊見久、田中亜由美、吉田知之、森寿、吉村徹
- Organizer
  D-アミノ酸学会
- Place of Presentation
  関西大学
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] 真核生物型D-セリンデヒドラターゼの触媒機構2012
- Author(s)
  伊藤智和
- Organizer
  2012年度酵素補酵素研究会
- Place of Presentation
  名古屋大学
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] 細胞性粘菌におけるD-セリンの代謝と機能2012
- Author(s)
  伊藤智和、萩泰典、濱内菜月、邊見　久、齊藤玉緒、吉村　徹
- Organizer
  第8回D-アミノ酸研究会学術講演会
- Place of Presentation
  滋賀医科大学
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] 亜鉛に依存するD-セリンデヒドラターゼ：亜鉛の役割と反応機構の解析2012
- Author(s)
  伊藤智和、松岡舞、邊見久、吉村徹
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] 細胞性粘菌におけるD-セリン代謝関連酵素とその生理機能2012
- Author(s)
  萩泰典、伊藤智和、齊藤玉緒、邊見久、吉村徹
- Organizer
  日本農芸化学会2012年度大会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 真核細胞型D-セリンデヒドラターゼの神経疾患解析への応用2011
- Author(s)
  伊藤智和、高田紘江、磯部恵子、邊見久、吉村徹
- Organizer
  日本ビタミン学会第63回大会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 真核生物D-セリンデヒドラーゼ:神経疾患解析への応用2011
- Author(s)
  高田紘江、磯部恵子、伊藤智和、邊見久、吉村徹
- Organizer
  日本農芸化学会2011年度大会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 真核生物型Dセリンデヒドラーゼにおける亜鉛の意義2011
- Author(s)
  伊藤智和、邊見久、吉村徹
- Organizer
  日本農芸化学会大会2011年度大会
- Place of Presentation
  要旨集
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 真核生物型Dセリンデヒドラーゼにおける亜鉛の意義2011
- Author(s)
  伊藤智和、邊見久、吉村徹
- Organizer
  日本農芸化学会2011年度大会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] Characterization of YggS from Escherichia coli : A unique PLP-dependent protein involved in the refulation of L-valine production2011
- Author(s)
  飯盛淳平、伊藤智和、邊見久、吉村徹
- Organizer
  IUMS201
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 新奇ビタミンB6タンパク質YggSの機能解析:E. coliにおけるL-バリン生合成制御2011
- Author(s)
  飯盛淳平、伊藤智和、邊見久、吉村徹
- Organizer
  第84回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] PEG化D-セリンデヒドラーゼの調製と物性の解析2011
- Author(s)
  高田紘江、磯部恵子、伊藤智和、邊見久、吉村徹
- Organizer
  第7回D-アミノ酸研究会学術講演会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] ビタミンB6を要求する細菌の転写制御因子、GabR2011
- Author(s)
  吉村徹、白木俊介、奥田啓太、深田はるみ、後藤勝、伊藤智和、邊見久
- Organizer
  日本ビタミン学会第63回大会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 真核生物D-セリンデヒドラーゼ:神経疾患解析への応用2011
- Author(s)
  高田紘江、磯部恵子、伊藤智和、邊見久、吉村徹
- Organizer
  日本農芸化学会大会2011年度大会
- Place of Presentation
  要旨集
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 細胞性粘菌におけるD-セリンの生理的役割の解明2011
- Author(s)
  萩泰典、伊藤智和、齊藤玉緒、邊見久、吉村徹
- Organizer
  第84回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 真核生物型D-セリンデヒドラーゼにおける亜鉛の意義2010
- Author(s)
  伊藤智和、邊見久、吉村徹
- Organizer
  酵素補酵素研究会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] Catalytic mechanisms of serine racemase from Dictyostelium discoideum2010
- Author(s)
  前川元貴、伊藤智和、後藤勝、邊見久、吉村徹
- Organizer
  日本生化学会大会2010年度大会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 細胞性粘菌、Dictyostelium discoideumの真核細胞型セリンラセマーゼに対する金属の影響2010
- Author(s)
  吉村徹、前川元貴、邊見久、伊藤智和
- Organizer
  日本ビタミン学会第62回大会
- Data Source
  KAKENHI-PROJECT-22880014
[Presentation] 亜鉛依存性D-セリンデヒドラターゼの反応機構：PLPピリジン環窒素の相互作用残基(Y203)の変異体解析
- Author(s)
  伊藤智和・松岡舞・邊見久・吉村徹
- Organizer
  日本ビタミン学会第 65回大会
- Place of Presentation
  姫路
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] Catalytic mechanism of PLP- and Zn2+-dependent D-serine dehydratase
- Author(s)
  Tomokazu Ito, Mai Matsuoka, Hisashi Hemmi, and Tohru Yoshimura
- Organizer
  4th International Conference on Cofactors (ICC-04)
- Place of Presentation
  Parma、Italy
- Year and Date
  2014-08-25 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-24780098
[Presentation] Brevibacillus brevisの新奇ピリドキサール5’-リン酸(PLP)結合性転写調節因子の解析
- Author(s)
  伊藤智和、竹中崇、邊見久、吉村徹
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2015-10-18
- Data Source
  KAKENHI-PROJECT-24780098

1. Hemmi Hisashi (60302189)

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18. 吉田明

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# of Collaborated Products: 1 results

ITO Tomokazu 伊藤 智和

Ito Tomokazu 伊藤 智和

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アミノ酸代謝フロー変化による脂肪蓄積メカニズムの解明

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「修飾型」葉酸の生物分布と分子機能の解明Principal Investigator

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Effective fermentative production of isoprenoid via oxygen-tolerant archaeal mevalonate pathway

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肥満・インスリン抵抗性におけるアミノ酸代謝フロー変化の解明とその応用

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Creation of microbial cells as the innovative chassis for isoprenoid production

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Elucidation of the function of a conserved pyridoxal phosphate-binding protein involved in the homeostasis of amino acid metabolismPrincipal Investigator

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D-amino acid biological system in eukaryotePrincipal Investigator

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Function and regulation of D-amino acid in eukaryotePrincipal Investigator

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Functions and metabolism of D-serine in eukaryotePrincipal Investigator

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[Journal Article] d‐amino acid auxotrophic Escherichia coli strain for in vivo functional cloning of novel d‐amino acid synthetic enzyme2023

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[Journal Article] A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway2023

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[Journal Article] Identification and functional analysis of a new type of Z,E-mixed prenyl reductase from mycobacteria2022

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[Journal Article] Mechanism of pyridoxine 5'-phosphate accumulation in pyridoxal 5'-phosohate-binding protein-deficiency2022

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[Journal Article] Identification and characterization of a serine racemase in the silkworm Bombyx mori2022

ITO Tomokazu 伊藤智和

Ito Tomokazu 伊藤智和