Toki Yasumichi 土岐康通

Researcher Number	90596280
Affiliation (based on the past Project Information) *help	2019 – 2020: 旭川医科大学, 医学部, 特任助教 2016 – 2018: 旭川医科大学, 大学病院, 医員 2015: 旭川医科大学, 大学病院, その他
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Laboratory medicine / Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator バイオマーカー / スプライシングバリアント / ヘプシジン Except Principal Investigator 鉄代謝 / バイオマーカー / 動脈硬化症 / NAFLD / 臨床検査医学 / 非トランスフェリン結合鉄 / labile plasma iron (LPI) … More / 鉄 / 非トランスフェリン結合鉄（NTBI） / 抗腫瘍効果 / フェロトーシス / 血清フェリチン / 鉄感知機構 / ヘプシジン / フェリチン Less

Anti-tumor effect achieved by effective induction of ferroptosis utilizing non-transferrin-bound iron
- Principal Investigator
  
  IKUTA KATSUYA
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Asahikawa Medical College
Elucidation of the significance of iron metabolism disorder-related molecules as cardioliver-related factors and clinical application of its measurement
- Principal Investigator
  
  Fujii Satoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Asahikawa Medical College
Investigation for iron sensing mechanism via the direct regulation of hepcidin expression by serum ferritin protein
- Principal Investigator
  
  IKUTA KATSUYA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Asahikawa Medical College
Usefulness as the biomarker and effect in the iron metabolism of new splicing variant of hepcidin with liver cancer originPrincipal Investigator
- Principal Investigator
  
  Toki Yasumichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] 輸血後鉄過剰症　診療の参照ガイド令和1年改訂版（担当：日本における原発性（遺伝性）鉄過剰症の種類と疫学 p133-136） p109-111）2020
- Author(s)
  土岐康通、生田克哉
- Total Pages
  52
- Publisher
  厚生労働省科学研究費補助金（難治性疾患政策研究事業）特発性造血障害に関する調査研究班編集
- Data Source
  KAKENHI-PROJECT-18K08347
[Book] Medical Practice、2016, vol. 33, no. 9（担当：慢性炎症に伴う貧血の病態（臨床に役立つ知識と情報））2016
- Author(s)
  土岐康道、生田克哉
- Total Pages
  166
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-15K09446
[Journal Article] Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: A case report.2021
- Author(s)
  Nishina S, Tomiyama Y, Ikuta K, Tatsumi Y, Toki Y, Kato A, Kato K, Yoshioka N, Sasaki K, Hara Y, Hino K.
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21(1) Issue: 1 Pages: 111-111
- DOI
  10.1186/s12876-021-01674-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08347, KAKENHI-PROJECT-19H03644, KAKENHI-PROJECT-21K07995
[Journal Article] Type 4B hereditary hemochromatosis due to heterozygous p.D157A mutation in SLC40A1 complicated with hypopituitarism.2021
- Author(s)
  Honma Y, Karasuyama T, Kumamoto K, Shimajiri S, Toki Y, Tatsumi Y, Sumida K, Koikawa K, Morino K, Oe S, Miyagawa K, Yamasaki M, Shibata M, Abe S, Ikuta K, Hayashi H, Harada M.
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: 54(1) Issue: 1 Pages: 60-67
- DOI
  10.1007/s00795-020-00259-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08347, KAKENHI-PROJECT-21K07926
[Journal Article] Identification of Heterozygous p.Y150C and p.V274M Mutations in the HJV Gene in a Japanese Patient With a Mild Phenotype of Juvenile Hemochromatosis: A Case Report2020
- Author(s)
  Kawaguchi T, Ikuta K, Tatsumi Y, Toki Y, Hayashi H, Tonan T, Ohtake T, Hoshino S, Naito M, Kato K, Okumura T, Torimura T.
- Journal Title
  
  Hepatology Research
  
  Volume: 50 (1) Issue: 1 Pages: 144-150
- DOI
  10.1111/hepr.13423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08347, KAKENHI-PROJECT-17K08971
[Journal Article] Juvenile Hemochromatosis: A Case Report and Review of the Literature2020
- Author(s)
  Takami Akiyoshi、Tatsumi Yasuaki、Sakai Katsuhisa、Toki Yasumichi、Ikuta Katsuya、Oohigashi Yuka、Takagi Junko、Kato Koichi、Takami Kazuhisa
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Issue: 8 Pages: 195-195
- DOI
  10.3390/ph13080195
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-18K08347
[Journal Article] Novel Automated Measuring System for Evaluating Labile Plasma Iron in Serum2019
- Author(s)
  Saito T, Ikuta K, Hatayama M, Shibusa K, Matsui K, Tanaka R, Toki Y, Kato D, Iizuka N, Okumura T.
- Journal Title
  
  Annals of Clinical Biochemistry
  
  Volume: 56 (6) Issue: 6 Pages: 654-661
- DOI
  10.1177/0004563219861413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08347, KAKENHI-PROJECT-17K08971
[Journal Article] Iron overload patients with unknown etiology from national survey in Japan.2017
- Author(s)
  Ikuta K, Hatayama M, Addo L, Toki Y, Sasaki K, Tatsumi Y, Hattori A, Kato A, Kato K, Hayashi H, Suzuki T, Kobune M, Tsutsui M, Gotoh A, Aota Y, Matsuura M, Hamada Y, Tokuda T, Komatsu N, Kohgo Y.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 105 Issue: 3 Pages: 353-360
- DOI
  10.1007/s12185-016-2141-9
- NAID
  120006425801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09446, KAKENHI-PROJECT-15K09489
[Journal Article] Reticulocyte hemoglobin equivalent as a potential marker for diagnosis of iron deficiency.2017
- Author(s)
  Toki Y, Ikuta K, Kawahara Y, Niizeki N, Kon K, Enomoto M, Tada Y, Hatayama M, Yamamoto M, Ito S, Shindo M, Kikuchi Y, Inoue M, Sato K, Fujiya M, Okumura T.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 印刷中 Issue: 1 Pages: 116-125
- DOI
  10.1007/s12185-017-2212-6
- NAID
  120006491647
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09446, KAKENHI-PROJECT-17K08971
[Journal Article] 網赤血球ヘモグロビン量とその臨床応用について2016
- Author(s)
  土岐康通、伊藤　巧、河原好絵、藤井　聡、生田克哉
- Journal Title
  
  自己血輸血
  
  Volume: 28 Pages: 141-144
- Data Source
  KAKENHI-PROJECT-15K09446
[Journal Article] A selective splicing variant of hepcidin mRNA in hepatocellular carcinoma cell lines.2016
- Author(s)
  Toki Y, Sasaki K, Tanaka H, Yamamoto M, Hatayama M, Ito S, Ikuta K, Shindo M, Hasebe T, Nakajima S, Sawada K, Fujiya M, Torimoto Y, Ohtake T, Kohgo Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 476 Issue: 4 Pages: 501-507
- DOI
  10.1016/j.bbrc.2016.05.153
- NAID
  120006337813
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26870026, KAKENHI-PROJECT-15K09446, KAKENHI-PROJECT-15K19302
[Journal Article] Iron-induced epigenetic abnormalities of mouse bone marrow through aberrant activation of aconitase and isocitrate dehydrogenase.2016
- Author(s)
  Yamamoto M, Tanaka H, Toki Y, Hatayama M, Ito S, Addo L, Shindo M, Sasaki K, Ikuta K, Ohtake T, Fujiya M, Torimoto Y, Kohgo Y.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 104 Issue: 4 Pages: 491-501
- DOI
  10.1007/s12185-016-2054-7
- NAID
  120006368090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09446
[Journal Article] In vivo behavior of NTBI revealed by automated quantification system.2016
- Author(s)
  Ito S, Ikuta K, Kato D, Lynda A, Shibusa K, Niizeki N, Toki Y, Hatayama M, Yamamoto M, Shindo M, Iizuka N, Kohgo Y, Fujiya M.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 104 Issue: 2 Pages: 175-181
- DOI
  10.1007/s12185-016-2002-6
- NAID
  120006337811
- Data Source
  KAKENHI-PROJECT-15K09446
[Journal Article] The three isoforms of hepcidin in human serum and their processing determined by liquid chromatography-tandem mass spectrometry (LC-tandem MS).2016
- Author(s)
  Addo L, Ikuta K, Tanaka H, Toki Y, Hatayama M, Yamamoto M, Ito S, Shindo M, Sasaki Y, Shimonaka Y, Fujiya M, Kohgo Y.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 103 Pages: 34-43
- NAID
  120005954154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09446
[Journal Article] 肝がん患者血清エキソソーム中に同定したヘプシジンmRNAの選択的スプライシング・バリアントに関する研究2015
- Author(s)
  土岐　康通
- Journal Title
  
  北海道医学雑誌
  
  Volume: 90 Pages: 31-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19302
[Journal Article] イムノクロマト迅速定量測定試薬「ポイントストリップフェリチン-3000」の基礎評価2015
- Author(s)
  渋佐琴恵、畑山真弓、土岐康通、山本昌代、伊藤　巧、進藤基博、藤谷幹浩、新関紀康、友田　豊、河合優一、Addo Lynda、生田克哉
- Journal Title
  
  臨床病理
  
  Volume: 63 Pages: 1371-1376
- NAID
  120005752871
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09446
[Presentation] Hereditary Hemochromatosis-related gene mutation analysis in Japan.2019
- Author(s)
  Saito T, Toki Y, Tamamura N, Funayama T, Igarashi S, Ishioh M, Hatayama M, Shindo M, Ikuta K, Torimoto Y, Tatsumi Y, Kato A, Hayashi H, Kato K, Okumura T.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08347
[Presentation] Homozygous I281T mutation in HJV causing indolent juvenile hemochromatosis with a middle to late onset.2019
- Author(s)
  Takami A, Tatsumi Y, Sakai K, Toki Y, Ikuta K, Kato K, Takami K.
- Organizer
  24th European Hematology Association Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08347
[Presentation] 血清の酸化活性能の新規測定系構築2018
- Author(s)
  齋藤豪志、生田克哉、畑山真弓、土岐康通、進藤基博、鳥本悦宏、松井康蔵、飯塚直美、奥村勝利．
- Organizer
  第42回日本鉄バイオサイエンス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08347
[Presentation] Suppression of erythropoiesis in the mouse model mimicking repeated-transfusion induced iron overload.2017
- Author(s)
  Masayo Yamamoto, Hiroki Tanaka, Masatomo Ishioh, Takeshi Saito, Yasumichi Toki, Mayumi Hatayama, Motohiro Shindo, Katsuya Ikuta, Yoshihiro Torimoto, Toshikatsu Okumura.
- Organizer
  Seventh Congress of the International BioIron Society (IBIS) Biennial World Meeting (BioIron 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09446
[Presentation] 本邦における遺伝性ヘモクロマトーシス責任遺伝子の変異．2017
- Author(s)
  土岐康通、生田克哉、畑山真弓、山本昌代、進藤基博、巽　康彰、加藤文子、林　久男、加藤宏一、鳥本悦宏、奥村利勝．
- Organizer
  第41回日本鉄バイオサイエンス学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09446
[Presentation] Development a novel reagent measuring redox activity of iron overload using an automated analyzer.2017
- Author(s)
  Mayumi Hatayama, Katsuya Ikuta, Masayo Yamamoto, Yasumichi Toki, Motohiro Shindo, Daisuke Kato, Naomi Iizuka, Toshikatsu Okumura.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09446
[Presentation] Update of the hereditary hemochromatosis-related gene mutation analysis in Japan.2017
- Author(s)
  Yasumichi Toki, Katsuya Ikuta, Masatomo Ishioh, Takeshi Saito, Mayumi Hatayama, Masayo Yamamoto, Motohiro Shindo, Yoshihiro Torimoto, Yasuaki Tatsumi, Ayako Kato, Hisao Hayashi, Koichi Kato, Toshikatsu Okumura.
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09446
[Presentation] 肝がん患者血清exosome中に同定したヘプシジンmRNAの選択的スプライシング・バリアントに関する研究2017
- Author(s)
  土岐　康通
- Organizer
  北海道癌談話会
- Data Source
  KAKENHI-PROJECT-15K19302
[Presentation] Usefulness of reticulocyte hemoglobin equivalent for diagnosis of iron deficiency.2016
- Author(s)
  Yasumichi Toki, Katsuya Ikuta, Masayo Yamamoto, Mayumi Hatayama, Motohiro Shindo, Mikihiro Fujiya, Toshikatsu Okumura.
- Organizer
  ASH 2016 (Annual Meeting of American Society of Hematology)
- Place of Presentation
  San Diego Convention Center, San Diego, CA, U.S.A
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09446
[Presentation] Non-transferrin-bound iron (NTBI) after chemotherapy for non-Hodgkin lymphoma.2016
- Author(s)
  Mayumi Hatayama, Katsuya Ikuta, Satoshi Ito, Takeshi Saito, Masayo Yamamoto, Yasumichi Toki, Motohiro Shindo, Yoshihiro Torimoto, Toshikatsu Okumura.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K09446
[Presentation] 網赤血球ヘモグロビン等量（Reticulocyte hemoglobin equivalent: RET-He）の鉄欠乏診断における有用性の検討2015
- Author(s)
  土岐康通、生田克哉、畑山真弓、山本昌代、伊藤　巧、進藤基博、菊地陽子、井上充貴、佐藤一也、鳥本悦宏、藤谷幹浩．
- Organizer
  第39回日本鉄バイオサイエンス学会学術集会
- Place of Presentation
  岡山コンベンションセンター（岡山）
- Year and Date
  2015-08-29
- Data Source
  KAKENHI-PROJECT-15K09446
[Presentation] Reticulocyte hemoglobin equivalent (RET-He) is a possible marker for diagnosis of iron deficiency.2015
- Author(s)
  Yasumichi Toki, Katsuya Ikuta, Satoshi Ito, Mayumi Hatayama, Masayo Yamamoto, Motohiro Shindo, Yoshihiro Torimoto, Kazuya Sato, Junki Inamura, Takaaki Hosoki, Kazuhiko Ichiki, Mikihiro Fujiya.
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂（金沢）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K09446
[Presentation] 鉄欠乏状態の診断における網赤血球ヘモグロビン等量（RET-He）の有用性に関する検討．2015
- Author(s)
  生田克哉、伊藤　巧、土岐康通、河原好絵、佐藤一也、今　昌幸、菊地陽子、多田裕子、井上充貴、榎本基樹．
- Organizer
  第16回日本検査血液学会学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-15K09446

1. IKUTA KATSUYA (00396376)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
2. Fujii Satoshi (90291228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 進藤基博 (10396377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
4. 伊藤巧 (80548686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
5. 田中宏樹 (70596155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 齋藤豪志 (80837930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 赤坂和美 (80344555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 澤田康司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 高見昭良

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Toki Yasumichi 土岐 康通

Research Projects

Research Products

Co-Researchers

Anti-tumor effect achieved by effective induction of ferroptosis utilizing non-transferrin-bound iron

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the significance of iron metabolism disorder-related molecules as cardioliver-related factors and clinical application of its measurement

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation for iron sensing mechanism via the direct regulation of hepcidin expression by serum ferritin protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Usefulness as the biomarker and effect in the iron metabolism of new splicing variant of hepcidin with liver cancer originPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 輸血後鉄過剰症 診療の参照ガイド令和1年改訂版（担当：日本における原発性（遺伝性）鉄過剰症の種類と疫学 p133-136） p109-111）2020

Author(s)

Total Pages

Publisher

Data Source

[Book] Medical Practice、2016, vol. 33, no. 9（担当：慢性炎症に伴う貧血の病態（臨床に役立つ知識と情報））2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: A case report.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Type 4B hereditary hemochromatosis due to heterozygous p.D157A mutation in SLC40A1 complicated with hypopituitarism.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Heterozygous p.Y150C and p.V274M Mutations in the HJV Gene in a Japanese Patient With a Mild Phenotype of Juvenile Hemochromatosis: A Case Report2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Juvenile Hemochromatosis: A Case Report and Review of the Literature2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Automated Measuring System for Evaluating Labile Plasma Iron in Serum2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Iron overload patients with unknown etiology from national survey in Japan.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Reticulocyte hemoglobin equivalent as a potential marker for diagnosis of iron deficiency.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 網赤血球ヘモグロビン量とその臨床応用について2016

Author(s)

Journal Title

Data Source

[Journal Article] A selective splicing variant of hepcidin mRNA in hepatocellular carcinoma cell lines.2016

Toki Yasumichi 土岐康通

[Book] 輸血後鉄過剰症　診療の参照ガイド令和1年改訂版（担当：日本における原発性（遺伝性）鉄過剰症の種類と疫学 p133-136） p109-111）2020