Komatsu Toshihiro 小松利広

… Alternative Names

小松利広コマツトシヒロ

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Researcher Number	90598517
Other IDs
Affiliation (Current)	2025: 高知大学, 教育研究部医療学系基礎医学部門, 助教
Affiliation (based on the past Project Information) *help	2025: 高知大学, 教育研究部医療学系基礎医学部門, 助教 2023: 高知大学, 教育研究部医療学系基礎医学部門, 助教 2016 – 2020: 高知大学, 教育研究部医療学系基礎医学部門, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 腫瘍 / 抗原提示 / 血管内皮細胞 / 制御性T細胞 / 腫瘍細胞 / 免疫学 / T細胞 / MHC class I 分子 / 細胞傷害性T細胞 / 腫瘍抗原 … More Except Principal Investigator … More antigen presentation / T cell / peptide / MHC / fibroblast / 腫瘍免疫 / ヘルパーT細胞 / 遺伝子 / miRNA / 血管内皮細胞 / 抗原提示 / T細胞 / がん免疫 Less

Peptide immunotherapy targeting FAP-positive fibroblasts for tumors and fibrotic diseases
- Principal Investigator
  
  宇高恵子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kochi University
腫瘍内への制御性T細胞の抗原特異的浸潤機構の解明Principal Investigator
- Principal Investigator
  
  小松利広
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kochi University
Analysis of endothelial cells presenting antigens to helper T cells in tumor microenvironment
- Principal Investigator
  
  Shimizu Takeyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kochi University
Elucidation of T cell infiltration mechanism into the tumor tissue by the antigen recognitionPrincipal Investigator
- Principal Investigator
  
  Komatsu Toshihiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Kochi University

All 2024 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion2020
- Author(s)
  Toshihiro Komatsu, Takeyuki Shimizu, Makoto Kanoh, Tomoya Miyakawa, Yoko Satta, Yoshiki Yasukochi, Rika Fujimoto, Motoki Tada, Kaori Machida, Sayo Kataoka, Keiko Udaka
- Journal Title
  
  Immunogenetics
  
  Volume: 72 Issue: 3 Pages: 143-153
- DOI
  10.1007/s00251-020-01154-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07299, KAKENHI-PROJECT-19K07775, KAKENHI-PLANNED-16H06498
[Journal Article] Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines2018
- Author(s)
  Nishikawa H, Taniguchi Y, Matsumoto T, Arima N, Masaki M, Shimamura Y, Inoue K, Horino T, Fujimoto S, Ohko K, Komatsu T, Udaka K, Sano S, Terada Y.
- Journal Title
  
  Kidney Int.
  
  Volume: 93 Issue: 3 Pages: 599-614
- DOI
  10.1016/j.kint.2017.09.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19491, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-16K14611, KAKENHI-PROJECT-18K08212, KAKENHI-PROJECT-18K11129
[Journal Article] Improvement of Peptide-Based Tumor Immunotherapy Using pH-Sensitive Fusogenic Polymer-Modified Liposomes.2016
- Author(s)
  Yoshizaki Y, Yuba E, Komatsu T, Udaka K, Harada A, Kono K
- Journal Title
  
  Molecules
  
  Volume: 21 Issue: 10 Pages: 1284-1284
- DOI
  10.3390/molecules21101284
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H03024, KAKENHI-PROJECT-15J12180, KAKENHI-PROJECT-16K14611, KAKENHI-PROJECT-26242049
[Presentation] Regulatory T cells suppress cross-presentation by vascular endothelial cells2024
- Author(s)
  Toshihiro Komatsu, Takeyuki Shimizu, Yoshiaki Kubota and Keiko Udaka
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14652
[Presentation] Optimization of culture condition and method of detection to monitor T cells specific for HLA-peptides in PBMCs2021
- Author(s)
  Keiko Udaka, Asami Nakata, Kaori Machida, Toshihiko Komatsu, Takeyuki Shimizu
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] ゲノム編集によるTAP欠損細胞を使ったMHCクラスI分子と抗原ペプチドの結合相互作用解析法2019
- Author(s)
  清水健之、小松利広、深澤太郎、片岡佐誉、宇高恵子
- Organizer
  第23回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] Construction of a platform to predict HLA-A*11:01-binding peptides2019
- Author(s)
  小松利広、清水健之、町田香織、山下慶子、中村祥紀、宇高恵子
- Organizer
  第23回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] Construction of a computational platform to predict HLA-A*11:01 binding peptides2019
- Author(s)
  Keiko Udaka, Toshihiro Komatsu, Takeyuki Shimizu
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] Development of a novel monoclonal antibody which binds to most HLA-A allomorphs in a peptide-dependent, yet sequence promiscuous fashion2018
- Author(s)
  Makoto Kanoh, Takeyuki Shimizu, Toshihiro Komatsu, Yuko Satta, Sayo Kataoka, Keiko Udaka
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07299
[Presentation] 固形腫瘍内へのT細胞の浸潤機構2018
- Author(s)
  小松　利広
- Organizer
  新学術領域研究「ネオ・セルフの生成・機能・構造」第1回若手の会（第2回領域班会議）
- Data Source
  KAKENHI-PROJECT-16K14611
[Presentation] Construction of a TAP deficient HLA class I-binding assay system with the use of CRISPR/Cas9 system2017
- Author(s)
  Takeyuki Shimizu, Toshihiro Komatsu, Keiko Udaka
- Organizer
  第46回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K14611
[Presentation] Extravasation of CTLs occurs by recognizing the MHC-peptide complexes cross-presented by vascular endothelial cells2017
- Author(s)
  Toshihiro Komatsu, Ryosuke Iwade, Mika Kijima, Takehito Sato, Keiko Udaka
- Organizer
  第46回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K14611
[Presentation] 血管内皮細胞のHLAクラスII発現は、T細胞浸潤及び膵腫瘍に対する傷害活性と関連する2016
- Author(s)
  宇高　恵子、木岐　淳、西森　功、西原　利治、小松　利広、西岡　千恵、鈴木　勝英
- Organizer
  第8回血液疾患免疫療法学会学術集会
- Place of Presentation
  北海道大学(北海道札幌市)
- Year and Date
  2016-09-03
- Data Source
  KAKENHI-PROJECT-16K14611
[Presentation] 血管内皮細胞のクロスプレゼンテーションによるCTLの固形腫瘍への抗原特異的浸潤2016
- Author(s)
  岩出　良介、横山　水紀、小松　利広、木嶋　美香、笠井　道之、清水　健之、佐藤　健人、宇高　恵子
- Organizer
  第15回四国免疫フォーラム
- Place of Presentation
  高知大学（高知県南国市）
- Year and Date
  2016-06-25
- Data Source
  KAKENHI-PROJECT-16K14611
[Presentation] Cross-presentation of tumor antigen by endothelial cells promotes infiltration of tumor specific CTLs2016
- Author(s)
  Komatsu T, Iwade R, Sato T, Udaka K
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター(沖縄県宜野湾市)
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K14611

1. 宇高恵子 (40263066)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. Shimizu Takeyuki (10339137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. 島村芳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Komatsu Toshihiro 小松 利広

小松 利広 コマツ トシヒロ

Research Projects

Research Products

Co-Researchers

Peptide immunotherapy targeting FAP-positive fibroblasts for tumors and fibrotic diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腫瘍内への制御性T細胞の抗原特異的浸潤機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of endothelial cells presenting antigens to helper T cells in tumor microenvironment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of T cell infiltration mechanism into the tumor tissue by the antigen recognitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improvement of Peptide-Based Tumor Immunotherapy Using pH-Sensitive Fusogenic Polymer-Modified Liposomes.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] Regulatory T cells suppress cross-presentation by vascular endothelial cells2024

Author(s)

Organizer

Data Source

[Presentation] Optimization of culture condition and method of detection to monitor T cells specific for HLA-peptides in PBMCs2021

Author(s)

Organizer

Data Source

[Presentation] ゲノム編集によるTAP欠損細胞を使ったMHCクラスI分子と抗原ペプチドの結合相互作用解析法2019

Author(s)

Organizer

Data Source

[Presentation] Construction of a platform to predict HLA-A*11:01-binding peptides2019

Author(s)

Organizer

Data Source

[Presentation] Construction of a computational platform to predict HLA-A*11:01 binding peptides2019

Author(s)

Organizer

Data Source

[Presentation] Development of a novel monoclonal antibody which binds to most HLA-A allomorphs in a peptide-dependent, yet sequence promiscuous fashion2018

Author(s)

Organizer

Data Source

[Presentation] 固形腫瘍内へのT細胞の浸潤機構2018

Author(s)

Organizer

Data Source

[Presentation] Construction of a TAP deficient HLA class I-binding assay system with the use of CRISPR/Cas9 system2017

Author(s)

Organizer

Data Source

[Presentation] Extravasation of CTLs occurs by recognizing the MHC-peptide complexes cross-presented by vascular endothelial cells2017

Author(s)

Organizer

Data Source

Komatsu Toshihiro 小松利広

小松利広コマツトシヒロ