Miyachi Hitoshi 宮地均

… Alternative Names

宮地均ミヤチヒトシ

MIYACHI Hitoshi 宮地均

Less

Researcher Number	90599200
Affiliation (Current)	2025: 京都大学, 医生物学研究所, 技術職員
Affiliation (based on the past Project Information) *help	2023: 京都大学, 医生物学研究所, 技術職員 2015 – 2016: 京都大学, ウイルス研究所, 技術専門職員 2013: 京都大学, ウイルス研究所, その他 2013: 京都大学, ウイルス研究所, 技術専門職員 2012: 京都大学, ウイルス研究所, 専門技術職員 2011: 京都大学, ウイルス研究所, 技術専門職員
Review Section/Research Field	Except Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Genome biology / General medical chemistry / Experimental pathology
Keywords	Except Principal Investigator ALS / 網膜 / 神経変性疾患 / AKT / Rosa26ノックインマウス / FLPo / Cre / Gt(ROSA)26Sor / エピゲノム / 性分化 … More / エピジェネティクス / ヒストン修飾 / 性決定 / メチル化 / ヒストン / 新規マウスモデル / 免疫疲弊 / 遺伝子改変マウス / T細胞 / PD-1 / 抑制受容体 / Ｔ細胞 / 抑制レセプター / がん免疫 / 自己免疫 / 免疫寛容 / 造血幹細胞 / リプログラミング / 造血幹細胞検出法 / 再生医学 Less

神経変性疾患の発症メカニズム解明を目的としたノックインマウスの開発
- Principal Investigator
  
  阪上起世
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Ritsumeikan University
  Nagahama Institute of Bio-Science and Technology
Molecular mechanism of epigenetic regulation of mammalian sex differentiation
- Principal Investigator
  
  TACHIBANA Makoto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Genome biology
- Research Institution
  The University of Tokushima
The mechanism of strong PD-1 expression leading to immuno-suppression.
- Principal Investigator
  
  CHIKUMA SHUNSUKE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Keio University
  Kyoto University
Direct reprogramming of fibroblasts to hemetopoietic stem cells
- Principal Investigator
  
  ITOH Katsuhiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University

All 2023 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination.2015
- Author(s)
  Kuroki S, Akiyoshi M, Ideguchi K, Kitano S, Miyachi H, Hirose M, Mise N, Abe K, Ogura A, Tachibana M.
- Journal Title
  
  Genesis.
  
  Volume: 53(6) Issue: 6 Pages: 387-93
- DOI
  10.1002/dvg.22863
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-26112509, KAKENHI-PUBLICLY-26112515, KAKENHI-PROJECT-26250025, KAKENHI-PROJECT-26250037
[Journal Article] Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations.2013
- Author(s)
  Tani-Ichi, S., Shimba, A., Wagatsuma, K., Miyachi, H., Kitano, S., Imai, K., Hara, T., and Ikuta, K.
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A.
  
  Volume: 110 Issue: 2 Pages: 612-617
- DOI
  10.1073/pnas.1219242110
- NAID
  120005241695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659202, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24790468, KAKENHI-PROJECT-24790469
[Journal Article] Oscillatory control of factors determining multipotency and fate in mouse neural progenitors2013
- Author(s)
  I. Imayoshi, A. Isomura, Y. Harima, K. Kawaguchi, H. Kori, H. Miyachi, T. Fujiwara, F. Ishidate, and R. Kageyama
- Journal Title
  
  Science
  
  Volume: 342 Issue: 6163 Pages: 1203-1208
- DOI
  10.1126/science.1242366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08031, KAKENHI-PLANNED-22123002, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24240049, KAKENHI-PROJECT-24680035, KAKENHI-PROJECT-24700293, KAKENHI-PROJECT-25890010
[Journal Article] JMJD1C, a JmjC Domain-Containing Protein, Is Required for Long-Term Maintenance of Male Germ Cells in Mice2013
- Author(s)
  Kuroki, S., Akiyoshi, M., Tokura, M., Miyachi, H., Nakai, Y., Kimura, H., Shinkai, Y., and Tachibana, M
- Journal Title
  
  Biol. Reprod
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a2013
- Author(s)
  Kuroki, S., Matoba, S., Akiyoshi, M., Matsumura, Y., Miyachi, H., Mise, N., Abe, K., Ogura, A., Wilhelm, D., Koopman, P., Nozaki, M., Kanai, Y., Shinkai, Y., and Tachibana, M
- Journal Title
  
  Science
  
  Volume: 341 Pages: 1106-1109
- NAID
  120005323045
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] In vivo analysis of Aicda gene regulation : a critical balance between upstream enhancers and intronic silencers governs appropriate expression2013
- Author(s)
  Huong le, T., Kobayashi, M., Nakata, M., Shioi, G., Miyachi, H., Honjo, T., and Nagaoka, H
- Journal Title
  
  PLoS One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cells2013
- Author(s)
  Deguchi, K., Nagamatsu, G., Miyachi, H., Kato, Y., Morita, S., Kimura, H., Kitano, S., Hatada, I., Saga, Y., Tachibana, M., and Shinkai, Y
- Journal Title
  
  Biol. Reprod
  
  Volume: 88 Pages: 36-36
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] Oscillatory control of factors determining multipotency and fate in mouse neural progenitors2013
- Author(s)
  Imayoshi, I., Isomura, A., Harima, Y., Kawaguchi, K., Kori, H., Miyachi, H., Fujiwara, T., Ishidate, F., and Kageyama, R
- Journal Title
  
  Science
  
  Volume: 342 Pages: 1203-1208
- NAID
  120005343917
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations2013
- Author(s)
  Tani-Ichi, S., Shimba, A., Wagatsuma, K., Miyachi, H., Kitano, S., Imai, K., Hara, T., and Ikuta, K
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A
  
  Volume: 110 Pages: 612-617
- NAID
  120005241695
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] Epigenetic regulation of sex determination by the histone demethylase Jmjd1a2013
- Author(s)
  Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, and Tachibana, M
- Journal Title
  
  Science
  
  Volume: 341 Issue: 6150 Pages: 1106-1109
- DOI
  10.1126/science.1239864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23651189, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24228005, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-25132703
[Journal Article] In vivo evaluation of PhiC31 recombinase activity in transgenic mice2012
- Author(s)
  Imayoshi, I., Hirano, K., Kitano, S., Miyachi, H., and Kageyama, R
- Journal Title
  
  Neurosci.Res
  
  Volume: 73 Pages: 106-114
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre- and Flp-mediated recombination2012
- Author(s)
  I.Imayoshi, K.Hirano, M.Sakamoto, G.Miyoshi, T.Imura, S.Kitano, H.Miyachi, R.Kageyama
- Journal Title
  
  Neuroscience Research
  
  Volume: 73 Issue: 1 Pages: 85-91
- DOI
  10.1016/j.neures.2012.02.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04652, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24240049, KAKENHI-PLANNED-22123002
[Journal Article] Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver2012
- Author(s)
  Liang, B., Hara, T., Wagatsuma, K., Zhang, J., Maki, K., Miyachi, H., Kitano, S., Yabe-Nishimura, C., Tani-Ichi, S., and Ikuta, K
- Journal Title
  
  J.Immunol
  
  Volume: 189 Pages: 4444-4450
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] A multifunctional teal-fluorescent Rosa26 reporter mouse line for Creand Flp-mediated recombination2012
- Author(s)
  Imayoshi, I., Hirano, K., Sakamoto, M., Miyoshi, G., Imura, T., Kitano, S., Miyachi, H., and Kageyama, R
- Journal Title
  
  Neurosci.Res
  
  Volume: 73 Pages: 85-91
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver.2012
- Author(s)
  Liang, B., T. Hara, K. Wagatsuma, J. Zhang, K. Maki, H. Miyachi, S. Kitano, C. Yabe-Nishimura, S. Tani-Ichi, and K. Ikuta
- Journal Title
  
  Journal of Immunology
  
  Volume: 189 Issue: 9 Pages: 4444-4450
- DOI
  10.4049/jimmunol.1201181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24790468, KAKENHI-PROJECT-24790469
[Journal Article] In vivo evaluation of PhiC31 recombinase activity in transgenic mice.2012
- Author(s)
  Imayoshi, I., K. Hirano, S. Kitano, H. Miyachi, and R. Kageyama
- Journal Title
  
  Neuroscience Research
  
  Volume: 73 Issue: 2 Pages: 106-114
- DOI
  10.1016/j.neures.2012.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659202, KAKENHI-PLANNED-22123002
[Journal Article] Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.02012
- Author(s)
  I.Imayoshi, S.Tabuchi, K.Hirano, M.Sakamoto, S.Kitano, H.Miyachi, A.Yamanaka, R.Kageyama, R.
- Journal Title
  
  Neuroscience Research
  
  Volume: (掲載確定)(印刷中) Issue: 1 Pages: 85-91
- DOI
  10.1016/j.neures.2012.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04652, KAKENHI-PROJECT-21240028, KAKENHI-PLANNED-23115103, KAKENHI-PROJECT-23300142, KAKENHI-PROJECT-23659128, KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24240049, KAKENHI-PLANNED-22123002
[Journal Article] Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice.2012
- Author(s)
  Hara, T., S. Shitara, K. Imai, H. Miyachi, S. Kitano, H. Yao, S. Tani-Ichi, and K. Ikuta
- Journal Title
  
  Journal of Immunology
  
  Volume: 189 Issue: 4 Pages: 1577-1584
- DOI
  10.4049/jimmunol.1200586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659202, KAKENHI-PROJECT-24790468
[Journal Article] Identification of IL-7-Producing Cells in Primary and Secondary Lymphoid Organs Using IL-7-GFP Knock-In Mice2012
- Author(s)
  Hara, T., Shitara, S., Imai, K., Miyachi, H., Kitano, S., Yao, H., Tani-Ichi, S., and Ikuta, K
- Journal Title
  
  J.Immunol
  
  Volume: 189 Pages: 1577-1584
- Data Source
  KAKENHI-PROJECT-23659202
[Journal Article] Light-induced silencing of neural activity in Rosa26 knock-in mice conditionally expressing the microbial halorhodopsin eNpHR2.02012
- Author(s)
  Imayoshi, I., Tabuchi, S., Hirano, K., Sakamoto, M., Kitano, S., Miyachi, H., Yamanaka, A., and Kageyama, R
- Journal Title
  
  Neurosci. Res
- Data Source
  KAKENHI-PROJECT-23659202
[Presentation] Gt(ROSA)26Sor-CAG-LF-AKT1ノックインマウス2系統（活性化型および野性型AKT）の樹立 Establishment of two Gt(ROSA)26Sor-CAG-LF-AKT1 knock-in mouse lines (active form and wild-type form) induced by Cre and FLP recombinases.2023
- Author(s)
  阪上起世、黒川理薫、宮地均、北野さつき、佐野裕美、林憲太、小倉淳
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K19582
[Presentation] CRISPR/Cas9 システムを利用した遺伝子編集マウス作製の実際2014
- Author(s)
  宮地均, 伊藤克彦, 他
- Organizer
  第61回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-23659202

1. ITOH Katsuhiko (90281097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. CHIKUMA SHUNSUKE (50437208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TACHIBANA Makoto (80303915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TAKEMOTO Keiko (90243104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 阪上起世 (10804924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 佐野裕美 (00363755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 小林憲太 (70315662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小倉淳郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 阿部訓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyachi Hitoshi 宮地 均

宮地 均 ミヤチ ヒトシ

MIYACHI Hitoshi 宮地 均

Research Projects

Research Products

Co-Researchers

神経変性疾患の発症メカニズム解明を目的としたノックインマウスの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of epigenetic regulation of mammalian sex differentiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of strong PD-1 expression leading to immuno-suppression.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Direct reprogramming of fibroblasts to hemetopoietic stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of a general-purpose method for cell purification using Cre/loxP-mediated recombination.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations.2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Oscillatory control of factors determining multipotency and fate in mouse neural progenitors2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] JMJD1C, a JmjC Domain-Containing Protein, Is Required for Long-Term Maintenance of Male Germ Cells in Mice2013

Author(s)

Journal Title

Data Source

[Journal Article] Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] In vivo analysis of Aicda gene regulation : a critical balance between upstream enhancers and intronic silencers governs appropriate expression2013

Author(s)

Journal Title

Data Source

[Journal Article] Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cells2013

Author(s)

Journal Title

Data Source

[Journal Article] Oscillatory control of factors determining multipotency and fate in mouse neural progenitors2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Epigenetic regulation of sex determination by the histone demethylase Jmjd1a2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo evaluation of PhiC31 recombinase activity in transgenic mice2012

Author(s)

Miyachi Hitoshi 宮地均

宮地均ミヤチヒトシ

MIYACHI Hitoshi 宮地均