Shimohata Takaaki 下畑隆明

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SHIMOHATA Takaaki 下畑隆明

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Researcher Number	90609687
Other IDs
Affiliation (Current)	2025: 福井県立大学, 海洋生物資源学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 福井県立大学, 海洋生物資源学部, 准教授 2018 – 2023: 徳島大学, 大学院医歯薬学研究部(医学域), 助教 2021 – 2022: 福井県立大学, 海洋生物資源学部, 准教授 2016 – 2017: 徳島大学, 大学院医歯薬学研究部(医学系), 助教 2015: 徳島大学, 大学院医歯薬学研究部, 助教 2014: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 2012 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 助教
Review Section/Research Field	Principal Investigator Eating habits / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Applied health science / Eating habits / Applied health science
Keywords	Principal Investigator アミノ酸 / カンピロバクター / 細菌叢 / オートファジー / mTOR / amino acid / Amino acid / Autophagy / Campylobacter jejuni / サイトカイン … More / VP1680 / 胃腸炎症 / エフェクター / 炎症 / III型分泌装置 / ３型分泌機構 / 腸炎 / 腸炎ビブリオ … More Except Principal Investigator 殺菌 / カンピロバクター / UVA / 血管内皮細胞 / 鶏肉 / 塩素 / LED / Gut microbiome / 中性脂肪 / 肝臓 / 腸内微生物細菌叢 / 概日リズム / 血管内皮機能 / 腸内微生物叢 / 腸内マイクロバイオーム / 病原性 / 紫外線 / 酸化ストレス / UVA-LED / 酸化 / Campylobacter jejuni / 一酸化窒素 / 心房血栓 Less

Study of Campylobacter nutritional preference and pathogenicity using human intestinal microbiotaPrincipal Investigator
- Principal Investigator
  
  下畑隆明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Fukui Prefectural University
Development of LED sterilization system for Campylobacter jejuni-contaminated raw chicken
- Principal Investigator
  
  HARADA Yumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  The University of Tokushima
腸内細菌叢の活性で調節される食物由来の概日リズム振動化合物の同定及びヒトへの応用
- Principal Investigator
  
  高橋章
- Project Period (FY)
  2018 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  The University of Tokushima
The study of nutrition starvation in Campylobacter jejuni infection for nutritional therapyPrincipal Investigator
- Principal Investigator
  
  SHIMOHATA Takaaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  The University of Tokushima
Interaction between gut microbiota and food-derived compounds for prevention and control of cardiovascular endothelial dysfunction
- Principal Investigator
  
  MAWATARI Kazuaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  The University of Tokushima
Development of new chicken store system focused on attenuation of Campylobacter jejuni invasion by UVA irradiation
- Principal Investigator
  
  HARADA Yumi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Eating habits
- Research Institution
  The University of Tokushima
Mechanism elucidation of Vibrio parahaemolyticus-mediated inflammation targeted for intestinal epithelial cell.Principal Investigator
- Principal Investigator
  
  SHIMOHATA Takaaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Eating habits
- Research Institution
  The University of Tokushima
Prevention of atrial thrombosis by food-derived bioactive components which act cardiovascular endothelial cells
- Principal Investigator
  
  MAWATARI Kazuaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  The University of Tokushima

All 2023 2022 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] The Polymethoxyflavone Sudachitin Modulates the Circadian Clock and Improves Liver Physiology2023
- Author(s)
  Mawatari Kazuaki、Koike Nobuya、Nohara Kazunari、Wirianto Marvin、Uebanso Takashi、Shimohata Takaaki、Shikishima Yasuhiro、Miura Hiroyuki、Nii Yoshitaka、Burish Mark J.、Yagita Kazuhiro、Takahashi Akira、Yoo Seung‐Hee、Chen Zheng
- Journal Title
  
  Molecular Nutrition & Food Research
  
  Volume: 67 Issue: 9 Pages: 2200270-2200270
- DOI
  10.1002/mnfr.202200270
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0274, KAKENHI-PROJECT-19K06770, KAKENHI-PROJECT-22K18366
[Journal Article] Recruitment of LC3 by Campylobacter jejuni to Bacterial Invasion Site on Host Cells via the Rac1-Mediated Signaling Pathway2022
- Author(s)
  Fukushima S, Shimohata T, Inoue Y, Kido J, Uebanso T, Mawatari K, Takahashi A.
- Journal Title
  
  Front Cell Infect Microbiol .
  
  Volume: 12
- DOI
  10.3389/fcimb.2022.829682
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H01616, KAKENHI-PROJECT-20K11647
[Journal Article] Cellular Tight Junctions Prevent Effective Campylobacter jejuni Invasion and Inflammatory Barrier Disruption Promoting Bacterial Invasion from Lateral Membrane in Polarized Intestinal Epithelial Cells2018
- Author(s)
  Hatayama Sho、Shimohata Takaaki、Amano Sachie、Kido Junko、Nguyen Anh Q.、Sato Yuri、Kanda Yuna、Tentaku Aya、Fukushima Shiho、Nakahashi Mutsumi、Uebanso Takashi、Mawatari Kazuaki、Takahashi Akira
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 8
- DOI
  10.3389/fcimb.2018.00015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870411, KAKENHI-PROJECT-15K00819
[Journal Article] Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice2018
- Author(s)
  Yoshimoto A, Uebanso T, Nakahashi M, Shimohata T, Mawatari K, Takahashi A.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 62 Issue: 2 Pages: 155-160
- DOI
  10.3164/jcbn.17-53
- NAID
  130006407472
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05647, KAKENHI-PROJECT-15K01717, KAKENHI-PROJECT-16K15191, KAKENHI-PROJECT-15KK0345
[Journal Article] Effects of Consuming Xylitol on Gut Microbiota and Lipid Metabolism in Mice2017
- Author(s)
  Takashi Uebanso, Saki Kano, Ayumi Yoshimoto, Chisato Naito, Takaaki Shimohata, Kazuaki Mawatari and Akira Takahashi
- Journal Title
  
  Nutrients
  
  Volume: 9(7) Issue: 7 Pages: 756-756
- DOI
  10.3390/nu9070756
- NAID
  120007097695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05647, KAKENHI-PROJECT-15K01717, KAKENHI-PROJECT-16K15191
[Journal Article] Effects of Low-Dose Non-Caloric Sweetener Consumption on Gut Microbiota in Mice2017
- Author(s)
  Uebanso Takashi、Ohnishi Ai、Kitayama Reiko、Yoshimoto Ayumi、Nakahashi Mutsumi、Shimohata Takaaki、Mawatari Kazuaki、Takahashi Akira
- Journal Title
  
  Nutrients
  
  Volume: 9 Issue: 6 Pages: 560-560
- DOI
  10.3390/nu9060560
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870411, KAKENHI-PROJECT-15H05647, KAKENHI-PROJECT-15K01717, KAKENHI-PROJECT-16K15191
[Journal Article] Cystic Fibrosis Transmembrane Conductance Regulator Reduces Microtubule-Dependent Campylobacter jejuni Invasion2017
- Author(s)
  Kido Junko、Shimohata Takaaki、Amano Sachie、Hatayama Sho、Nguyen Anh Quoc、Sato Yuri、Kanda Yuna、Tentaku Aya、Fukushima Shiho、Nakahashi Mutsumi、Uebanso Takashi、Mawatari Kazuaki、Takahashi Akira
- Journal Title
  
  Infection and Immunity
  
  Volume: 85 Issue: 10
- DOI
  10.1128/iai.00311-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870411, KAKENHI-PROJECT-15K00819
[Journal Article] Enhancement of Endothelial Function Inhibits Left Atrial Thrombi Development in an Animal Model of Spontaneous Left Atrial Thrombosis2014
- Author(s)
  Kazuaki Mawatari, Emiko Yoshioka, Satomi Toda, Sonoko Yasui, Hiroko Furukawa, Takaaki Shimohata, Takamasa Ohnishi, Masaki Morishima, Nagakatsu Harada, Akira Takahashi, Hiroshi Sakaue, Yutaka Nakaya
- Journal Title
  
  Circ J
  
  Volume: 78 Issue: 8 Pages: 1980-1988
- DOI
  10.1253/circj.CJ-13-1398
- NAID
  130004427936
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500857
[Presentation] スダチ果皮特有のフラボノイド・スダチチンの概日リズム調節作用と肝脂質代謝改善作用2023
- Author(s)
  馬渡一諭, 小池宣也, 野原一成, 敷島康普, 三浦宏之, 新居佳孝, 上番増喬, 下畑隆明, 八木田和弘, 髙橋章, Seung-Hee Yoo, Zheng Chen
- Organizer
  第267回徳島医学会学術集会
- Data Source
  KAKENHI-PROJECT-18KK0274
[Presentation] スダチ由来ポリメトキシフラボン・スダチチンの概日リズム調節作用と肝脂質代謝改善作用2023
- Author(s)
  馬渡一諭, 小池宣也, 野原一成, 敷島康普, 三浦宏之, 新居佳孝, 上番増喬, 下畑隆明, 八木田和弘, 髙橋章, Seung-Hee Yoo, Zheng Chen
- Organizer
  第77回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-18KK0274
[Presentation] Campylobacter jejuni感染における小胞体ストレス応答は菌の侵入を抑制する2017
- Author(s)
  天宅あや, 下畑隆明, 畑山翔, NGUYEN QUOC ANH, 木戸純子, 福島志帆, 上番増喬, 馬渡一諭, 髙橋章
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] Campylobacter jejuni感染で誘導されるオートファジーは，宿主上皮細胞における菌の侵入および生存を促進する2017
- Author(s)
  福島志帆, 下畑隆明, 畑山翔, 木戸純子, 天宅あや, 上番増喬, 馬渡一諭, 髙橋章
- Organizer
  第256回徳島医学会学術集会
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] Campylobacter jejuni感染における小胞体ストレスの誘導2017
- Author(s)
  天宅あや, 下畑隆明, 木戸純子, 上番増喬, 馬渡一諭, 髙橋章
- Organizer
  第91回日本感染症学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] 宿主腸管上皮細胞のTight Junction形成が食中毒原因菌Campylobacter jejuniの侵入機構に及ぼす影響について2017
- Author(s)
  畑山翔, 下畑隆明, 天野幸恵, 木戸純子, 神田結奈, 天宅あや, 福島志帆, 中橋睦美, 上番増喬, 馬渡一諭, 髙橋章
- Organizer
  第71回日本栄養食糧学会
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] Campylobacter jejuni感染で誘導されるオートファジーは菌のクリアランス機構として働くのか2017
- Author(s)
  福島志帆, 下畑隆明, 畑山翔, 木戸純子, 天宅あや, 神田結奈, 鳴滝涼香, 石田快, 上番増喬, 馬渡一諭, 髙橋章
- Organizer
  第38回日本食品微生物学会学術総会
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] Does metabolites in gut world reflect effect of dietary ingredients on gut microbial community?2017
- Author(s)
  Takashi Uebanso, Ayumi Yoshimoto, Takaaki Shimohata, Mutsumi, Nakahashi, Kazuaki Mawatari, Akira Takahashi
- Organizer
  The 90th Annual Meeting of Japanese Society for Bacteriology
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01717
[Presentation] Campylobacter jejuni infection activates amino acid uptake in HeLa cell2017
- Author(s)
  下畑隆明, 木戸純子, 佐藤優里, 畑山翔, 神田結奈, 福島志帆, 天宅あや, 上番増喬, 馬渡一諭, 高橋章
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] 代謝産物の解析から紐解くCampylobacter jejuniの宿主細胞内生存戦略2017
- Author(s)
  下畑隆明, 木戸純子, 畑山翔, 上番増喬, 馬渡一諭, 髙橋章
- Organizer
  第70回日本細菌学会中国・四国支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] CFTR reduced microtubule-mediated Campylobacter jejuni invasion2017
- Author(s)
  木戸純子, 下畑隆明, 天野幸恵, 畑山翔, 佐藤優里, 神田結奈, 天宅あや, 福島志帆, 中橋睦美, 上番増喬, 馬渡一諭, 髙橋章
- Organizer
  日米医学協力研究会コレラ・細菌性腸管感染症専門部会
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] Campylobacter jejuniの宿主細胞内生存戦略に関する検討2016
- Author(s)
  下畑隆明，福島志帆，佐藤優里，扶川留音,　木戸純子，神田結奈，天宅あや，畑山翔,　中橋睦美，上番増喬，馬渡一諭，高橋章
- Organizer
  第69回日本細菌学会中国・四国支部総会
- Place of Presentation
  かがわ国際会議場（香川県・高松市）
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] 上皮細胞に侵入したCampylobacter jejuniのエネルギー獲得機構について2016
- Author(s)
  下畑隆明、福島志帆、佐藤優里、扶川留音、木戸純子、神田結奈、天宅あや、畑山翔、中橋睦美、上番増喬、原田永勝、馬渡一諭、高橋章
- Organizer
  第37回日本食品微生物学会学術総会
- Place of Presentation
  タワーホール船堀（東京都・江戸川区）
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] 代謝解析で明らかとなったCampylobacter jejuni感染による宿主細胞での特徴的なアミノ酸変動について2016
- Author(s)
  下畑隆明、佐藤優里、扶川留音、木戸純子、天野幸恵、畑山翔、中橋睦美、上番増喬、原田永勝、馬渡一諭、高橋章
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] メタボローム解析を用いた宿主細胞内のCampylobacter jejuniのエネルギー源獲得機構の検索2015
- Author(s)
  佐藤優里、下畑隆明、扶川留音、根来幸恵、畑山翔、木戸純子、上番増喬、原田永勝、馬渡一諭、高橋章
- Organizer
  日本カンピロバクター研究会総会
- Place of Presentation
  京都大学桂キャンパス（京都府京都市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K00819
[Presentation] Acceptable daily intake levels of sucralose consumption reduces fecal Clostridium cluster 4 in mouse2015
- Author(s)
  Takashi Uebanso, Ai Ohnishi, Takaaki Shimohata, Mutsumi Nakahashi, Kazuaki Mawatari, Akira Takahashi
- Organizer
  12th Asian Congress of Nutrition
- Place of Presentation
  パシフィコ横浜（神奈川県、横浜市）
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01717
[Presentation] Campylobacter jejuniに対するUVA-LEDの有効性2015
- Author(s)
  常冨愛香里、下畑隆明、後藤茉凛、天野幸恵、中橋睦美、上番増喬、馬渡一諭、宮脇克行、榎本崇宏、芥川正武、木内陽介、高橋章
- Organizer
  第８回日本カンピロバクター研究会総会
- Place of Presentation
  京都大学桂キャンパス（京都府京都市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26560046
[Presentation] 腸炎ビブリオの3型分泌装置遺伝子発現は細胞接着により誘導される2013
- Author(s)
  浅田翔子, 射場仁美, 下畑隆明, 上番増喬, 馬渡一諭, 髙橋章
- Organizer
  第247回徳島医学会学術集会
- Place of Presentation
  徳島大学大塚講堂（徳島県）
- Data Source
  KAKENHI-PROJECT-25750043

1. MAWATARI Kazuaki (40352372)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. Nakahashi Mutsumi (60596211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. HARADA Yumi (80568395)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 高橋章 (90304047)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 上番増喬 (10581829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 山田苑子 (30716634)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shimohata Takaaki 下畑 隆明

SHIMOHATA Takaaki 下畑 隆明

Research Projects

Research Products

Co-Researchers

Study of Campylobacter nutritional preference and pathogenicity using human intestinal microbiotaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of LED sterilization system for Campylobacter jejuni-contaminated raw chicken

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腸内細菌叢の活性で調節される食物由来の概日リズム振動化合物の同定及びヒトへの応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study of nutrition starvation in Campylobacter jejuni infection for nutritional therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Interaction between gut microbiota and food-derived compounds for prevention and control of cardiovascular endothelial dysfunction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new chicken store system focused on attenuation of Campylobacter jejuni invasion by UVA irradiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism elucidation of Vibrio parahaemolyticus-mediated inflammation targeted for intestinal epithelial cell.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prevention of atrial thrombosis by food-derived bioactive components which act cardiovascular endothelial cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Polymethoxyflavone Sudachitin Modulates the Circadian Clock and Improves Liver Physiology2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recruitment of LC3 by Campylobacter jejuni to Bacterial Invasion Site on Host Cells via the Rac1-Mediated Signaling Pathway2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular Tight Junctions Prevent Effective Campylobacter jejuni Invasion and Inflammatory Barrier Disruption Promoting Bacterial Invasion from Lateral Membrane in Polarized Intestinal Epithelial Cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Effects of Consuming Xylitol on Gut Microbiota and Lipid Metabolism in Mice2017

Author(s)

Journal Title

DOI

Shimohata Takaaki 下畑隆明

SHIMOHATA Takaaki 下畑隆明

[Presentation] スダチ由来ポリメトキシフラボン・スダチチンの概日リズム調節作用と肝脂質代謝改善作用2023