Tsuchiya Yoshihiro 土谷佳弘

… Alternative Names

TSUCHIYA Yoshihiro 土谷佳弘

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Researcher Number	90611301
Other IDs
Affiliation (Current)	2025: 広島女学院大学, 人間生活学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2018: 広島女学院大学, 人間生活学部, 准教授 2015 – 2016: 広島大学, 医歯薬保健学研究院(医), 助教 2015: 広島大学, 医歯薬学保健学研究院(医), 助教 2014: 広島大学, 医歯薬保健学研究院, 助教 2013: 広島大学, 医歯薬保健学研究院(歯), 助教 … More 2012: 広島大学, 医歯薬保健学研究院, 特任助教 2012: 広島大学, 大学院・医歯薬保健学研究院, 特任助教 2011: 広島大学, 大学院・医歯薬学総合研究科, 特任助教 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Tumor biology
Keywords	Principal Investigator IKK / 肝線維化 / 肝がん / IKKβ / 肝炎 / NF-kB / 肝細胞死 / HNF4 / DEN / HCC … More / シトクロムp450 / 化学発がん / 肝障害 / 細胞死 / 紫外線 / 炎症 / アダプター / ストレス応答 / 細胞内シグナル伝達 / NF-κB Less

Nuclear IKKbeta regulates DEN-induced hepatic carcinogenesis through the suppression of DNA-binding activity of HNF4alphaPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Yoshihiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Hiroshima Jogakuin University
  Hiroshima University
Nuclear IKKbeta regulates necroptosis and hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  Tsuchiya Yoshihiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hiroshima University
Stress-induced NF-κB mediated by the nuclear IKKβandcelldeathPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Yoshihiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional biochemistry
- Research Institution
  Hiroshima University

All 2018 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] 医学のあゆみ　活性酸素2013
- Author(s)
  土谷佳弘、鎌田英明
- Total Pages
  988
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-25840035
[Journal Article] Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding2018
- Author(s)
  Kanamoto Mayu、Tsuchiya Yoshihiro、Nakao Yuki、Suzuki Takafumi、Motohashi Hozumi、Yamamoto Masayuki、Kamata Hideaki
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 11 Pages: e0203978-e0203978
- DOI
  10.1371/journal.pone.0203978
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04794, KAKENHI-PUBLICLY-18H04963, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-16K18419, KAKENHI-PROJECT-17K15590
[Journal Article] Distinct B subunits of PP2A regulate the NF-κB signalling pathway through dephosphorylation of IKKβ, IκBα and RelA2017
- Author(s)
  Tsuchiya Yoshihiro、Osaki Keiko、Kanamoto Mayu、Nakao Yuki、Takahashi Ena、Higuchi Toru、Kamata Hideaki
- Journal Title
  
  FEBS Letters
  
  Volume: 591 Issue: 24 Pages: 4083-4094
- DOI
  10.1002/1873-3468.12912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18419
[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012
- Author(s)
  Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
- Journal Title
  
  American Journal of Physiology - Endocrinology and Metabolism
  
  Volume: 302 Issue: 3 Pages: 286-296
- DOI
  10.1152/ajpendo.00324.2011
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-21390556, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23390213, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022, KAKENHI-PROJECT-24790928
[Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model2012
- Author(s)
  Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 53 Pages: 44526-44535
- DOI
  10.1074/jbc.m112.397133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390556, KAKENHI-PUBLICLY-23013007, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022, KAKENHI-PROJECT-24249047, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24790928
[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011
- Author(s)
  Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 23 Pages: 20812-20822
- DOI
  10.1074/jbc.m110.206904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390556, KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-22790869, KAKENHI-PROJECT-23390238, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022
[Presentation] IKKβ遺伝子の改変により生じた肝臓における慢性炎症は遺伝子発現の改変を介して化学発がんを抑制する2017
- Author(s)
  土谷佳弘、金井昭教、金輪真佐美、外丸祐介、前田愼、鎌田英明
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K18419
[Presentation] IKKβ遺伝子改変マウスにおける肝線維化誘導と肝がん抑制機構2016
- Author(s)
  土谷佳弘, 松永泰花, 中津祐介, 鎌田英明
- Organizer
  第39回日本分子生物学年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K18419
[Presentation] Suppression of chemical hepatocarcinogenesis in transgenic mice expressing nuclear-localized kinase negative IKKβ2016
- Author(s)
  土谷佳弘, 松永泰花, 外丸祐介, 前田愼, 鎌田英明.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K18419
[Presentation] 肝細胞特異的IKKβ遺伝子改変マウスにおける酸化ストレスと肝細胞がんの抑制と細胞死の発生と肝細胞がんの抑制2016
- Author(s)
  土谷佳弘, 松永泰花, 外丸祐介, 前田愼,　鎌田英明,
- Organizer
  第89回日本生化学大会, 仙台, 2016.9.26
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K18419
[Presentation] RelAの転写活性化ドメイン(TAD)を介したIKK活性制御機構2015
- Author(s)
  土谷佳弘、樋口徹、松永泰花、高橋江奈、中津祐介、浅野知一郎、鎌田英明
- Organizer
  BMB2015
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25840035
[Presentation] RelA associates Hsp70 and suppresses IKKbeta; activity in a trascription-independent manner2013
- Author(s)
  Yoshihihiro Tsuchiya, Mayu Kanamoto, Masamoto Kanno, Tomoichiro Asano, Hideaki Kamata
- Organizer
  第３６回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-25840035
[Presentation] Stress-induced NF-kappaB activation mediated by the nuclear IKKbeta and cell death2013
- Author(s)
  Yoshihihiro Tsuchiya, Mayu Kanamoto, Masamoto Kanno, Tomoichiro Asano, Hideaki Kamata
- Organizer
  第８６回　日本生化学大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25840035
[Presentation] Stress-induced NF-kB activation mediated by the nuclear IKK and cell death2012
- Author(s)
  土谷佳弘
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23870022
[Presentation] Nuclear IKKβ acts as an adaptor protein for IκBα ubiquitination and degradation in UV- and oxidative stress-induced NF-κB activation. Keystone Symposium2012
- Author(s)
  Yoshihiro Tsuchiya, Tomoichiro Asano, Keiko Nakayama, Tomohisa Kato, Jr., Michael Karin, and Hideaki Kamata
- Organizer
  NF-kappaB Signaling and Biology: From Bench to Bedside
- Place of Presentation
  Whistler, British Columbia, Canada
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-23870022
[Presentation] Stress-induced NF-kB activation mediated by the nuclear IKK and cell death2012
- Author(s)
  土谷佳弘, 金本麻裕, 菅野雅元, 浅野知一郎, 鎌田英明
- Organizer
  35回日本分子生物学会
- Place of Presentation
  福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-23870022
[Presentation] IKKβの脱リン酸化反応における転写因子RelAの関与2012
- Author(s)
  土谷佳弘, 金本麻裕, 菅野雅元, 浅野知一郎, 鎌田英明
- Organizer
  第85回日本生化学会合同大会ワークショップ
- Place of Presentation
  福岡
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23870022
[Presentation] IKKβ act as an adaptor protein for IκBα ubiquitination and degradation in UV-induced NF-κB activation ; possible involvement in the TNF sign aling2011
- Author(s)
  Yoshihiro Tsuchiya
- Organizer
  13th International TNF Conference
- Place of Presentation
  淡路
- Year and Date
  2011-05-17
- Data Source
  KAKENHI-PROJECT-23870022
[Presentation] IKKβ act as an adaptor protein for IκBα ubiquitination and degradation in UV-induced NF-κB activation; possible involvement in the TNF signaling2011
- Author(s)
  Yoshihiro Tsuchiya a n d H i d e a k i K a m a t a
- Organizer
  13th International TNF Conference
- Place of Presentation
  Awajishima
- Year and Date
  2011-05-17
- Data Source
  KAKENHI-PROJECT-23870022
[Presentation] IKKβの多重的活性制御機構ー転写因子p65 によるネガティブフィードバックとレドックス制御の関与2011
- Author(s)
  土谷佳弘, 浅野知一郎, 菅野雅元,鎌田英明
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23870022
[Presentation] IKKbetaの多重的活性制御機構-転写因子p65によるネガティブフィードバックとレドックス制御の関与2011
- Author(s)
  土谷佳弘
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23870022
[Presentation] RelA suppresses IKKb activity in a trascription-independent manner
- Author(s)
  土谷佳弘, 浅野知一郎, 鎌田英明
- Organizer
  第87回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25840035
[Presentation] RelAによる遺伝子発現非依存的なIKK活性制御機構
- Author(s)
  土谷佳弘, 浅野知一郎, 鎌田英明
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25840035

1. KAMATA Hideaki (10233925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. NAKATSU Yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 浅野知一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 西村英紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsuchiya Yoshihiro 土谷 佳弘

TSUCHIYA Yoshihiro 土谷 佳弘

Research Projects

Research Products

Co-Researchers

Nuclear IKKbeta regulates DEN-induced hepatic carcinogenesis through the suppression of DNA-binding activity of HNF4alphaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nuclear IKKbeta regulates necroptosis and hepatocellular carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Stress-induced NF-κB mediated by the nuclear IKKβandcelldeathPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医学のあゆみ 活性酸素2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct B subunits of PP2A regulate the NF-κB signalling pathway through dephosphorylation of IKKβ, IκBα and RelA2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] IKKβ遺伝子の改変により生じた肝臓における慢性炎症は遺伝子発現の改変を介して化学発がんを抑制する2017

Author(s)

Organizer

Data Source

[Presentation] IKKβ遺伝子改変マウスにおける肝線維化誘導と肝がん抑制機構2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Suppression of chemical hepatocarcinogenesis in transgenic mice expressing nuclear-localized kinase negative IKKβ2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 肝細胞特異的IKKβ遺伝子改変マウスにおける酸化ストレスと肝細胞がんの抑制と細胞死の発生と肝細胞がんの抑制2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] RelAの転写活性化ドメイン(TAD)を介したIKK活性制御機構2015

Author(s)

Organizer

Place of Presentation

Year and Date

Tsuchiya Yoshihiro 土谷佳弘

TSUCHIYA Yoshihiro 土谷佳弘

[Book] 医学のあゆみ　活性酸素2013