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Tsuchiya Yoshihiro  土谷 佳弘

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TSUCHIYA Yoshihiro  土谷 佳弘

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Researcher Number 90611301
Other IDs
Affiliation (Current) 2025: 広島女学院大学, 人間生活学部, 准教授
Affiliation (based on the past Project Information) *help 2017 – 2018: 広島女学院大学, 人間生活学部, 准教授
2015 – 2016: 広島大学, 医歯薬保健学研究院(医), 助教
2015: 広島大学, 医歯薬学保健学研究院(医), 助教
2014: 広島大学, 医歯薬保健学研究院, 助教
2013: 広島大学, 医歯薬保健学研究院(歯), 助教 … More
2012: 広島大学, 医歯薬保健学研究院, 特任助教
2012: 広島大学, 大学院・医歯薬保健学研究院, 特任助教
2011: 広島大学, 大学院・医歯薬学総合研究科, 特任助教 Less
Review Section/Research Field
Principal Investigator
Functional biochemistry / Tumor biology
Keywords
Principal Investigator
IKK / 肝線維化 / 肝がん / IKKβ / 肝炎 / NF-kB / 肝細胞死 / HNF4 / DEN / HCC … More / シトクロムp450 / 化学発がん / 肝障害 / 細胞死 / 紫外線 / 炎症 / アダプター / ストレス応答 / 細胞内シグナル伝達 / NF-κB Less
  • Research Projects

    (3 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (5 People)
  •  Nuclear IKKbeta regulates DEN-induced hepatic carcinogenesis through the suppression of DNA-binding activity of HNF4alphaPrincipal Investigator

    • Principal Investigator
      TSUCHIYA Yoshihiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      Hiroshima Jogakuin University
      Hiroshima University
  •  Nuclear IKKbeta regulates necroptosis and hepatocellular carcinomaPrincipal Investigator

    • Principal Investigator
      Tsuchiya Yoshihiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Hiroshima University
  •  Stress-induced NF-κB mediated by the nuclear IKKβandcelldeathPrincipal Investigator

    • Principal Investigator
      TSUCHIYA Yoshihiro
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Functional biochemistry
    • Research Institution
      Hiroshima University

All 2018 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] 医学のあゆみ 活性酸素2013

    • Author(s)
      土谷佳弘、鎌田英明
    • Total Pages
      988
    • Publisher
      医歯薬出版株式会社
    • Data Source
      KAKENHI-PROJECT-25840035
  • [Journal Article] Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding2018

    • Author(s)
      Kanamoto Mayu、Tsuchiya Yoshihiro、Nakao Yuki、Suzuki Takafumi、Motohashi Hozumi、Yamamoto Masayuki、Kamata Hideaki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 11 Pages: e0203978-e0203978

    • DOI

      10.1371/journal.pone.0203978

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04794, KAKENHI-PUBLICLY-18H04963, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-16K18419, KAKENHI-PROJECT-17K15590
  • [Journal Article] Distinct B subunits of PP2A regulate the NF-κB signalling pathway through dephosphorylation of IKKβ, IκBα and RelA2017

    • Author(s)
      Tsuchiya Yoshihiro、Osaki Keiko、Kanamoto Mayu、Nakao Yuki、Takahashi Ena、Higuchi Toru、Kamata Hideaki
    • Journal Title

      FEBS Letters

      Volume: 591 Issue: 24 Pages: 4083-4094

    • DOI

      10.1002/1873-3468.12912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K18419
  • [Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012

    • Author(s)
      Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
    • Journal Title

      American Journal of Physiology - Endocrinology and Metabolism

      Volume: 302 Issue: 3 Pages: 286-296

    • DOI

      10.1152/ajpendo.00324.2011

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-21390556, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23390213, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022, KAKENHI-PROJECT-24790928
  • [Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model2012

    • Author(s)
      Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 53 Pages: 44526-44535

    • DOI

      10.1074/jbc.m112.397133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390556, KAKENHI-PUBLICLY-23013007, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022, KAKENHI-PROJECT-24249047, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24790928
  • [Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011

    • Author(s)
      Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 23 Pages: 20812-20822

    • DOI

      10.1074/jbc.m110.206904

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390556, KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-22790869, KAKENHI-PROJECT-23390238, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022
  • [Presentation] IKKβ遺伝子の改変により生じた肝臓における慢性炎症は遺伝子発現の改変を介して化学発がんを抑制する2017

    • Author(s)
      土谷 佳弘、金井 昭教、金輪 真佐美、外丸 祐介、前田 愼、鎌田 英明
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-16K18419
  • [Presentation] IKKβ遺伝子改変マウスにおける肝線維化誘導と肝がん抑制機構2016

    • Author(s)
      土谷佳弘, 松永泰花, 中津祐介, 鎌田英明
    • Organizer
      第39回日本分子生物学年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16K18419
  • [Presentation] Suppression of chemical hepatocarcinogenesis in transgenic mice expressing nuclear-localized kinase negative IKKβ2016

    • Author(s)
      土谷佳弘, 松永泰花, 外丸祐介, 前田愼, 鎌田英明.
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K18419
  • [Presentation] 肝細胞特異的IKKβ遺伝子改変マウスにおける酸化ストレスと肝細胞がんの抑制と細胞死の発生と肝細胞がんの抑制2016

    • Author(s)
      土谷佳弘, 松永泰花, 外丸祐介, 前田愼, 鎌田英明,
    • Organizer
      第89回日本生化学大会, 仙台, 2016.9.26
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16K18419
  • [Presentation] RelAの転写活性化ドメイン(TAD)を介したIKK活性制御機構2015

    • Author(s)
      土谷佳弘、樋口徹、松永泰花、高橋江奈、中津祐介、浅野知一郎、鎌田英明
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25840035
  • [Presentation] RelA associates Hsp70 and suppresses IKKbeta; activity in a trascription-independent manner2013

    • Author(s)
      Yoshihihiro Tsuchiya, Mayu Kanamoto, Masamoto Kanno, Tomoichiro Asano, Hideaki Kamata
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Data Source
      KAKENHI-PROJECT-25840035
  • [Presentation] Stress-induced NF-kappaB activation mediated by the nuclear IKKbeta and cell death2013

    • Author(s)
      Yoshihihiro Tsuchiya, Mayu Kanamoto, Masamoto Kanno, Tomoichiro Asano, Hideaki Kamata
    • Organizer
      第86回 日本生化学大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-25840035
  • [Presentation] Stress-induced NF-kB activation mediated by the nuclear IKK and cell death2012

    • Author(s)
      土谷佳弘
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23870022
  • [Presentation] Nuclear IKKβ acts as an adaptor protein for IκBα ubiquitination and degradation in UV- and oxidative stress-induced NF-κB activation. Keystone Symposium2012

    • Author(s)
      Yoshihiro Tsuchiya, Tomoichiro Asano, Keiko Nakayama, Tomohisa Kato, Jr., Michael Karin, and Hideaki Kamata
    • Organizer
      NF-kappaB Signaling and Biology: From Bench to Bedside
    • Place of Presentation
      Whistler, British Columbia, Canada
    • Year and Date
      2012-03-25
    • Data Source
      KAKENHI-PROJECT-23870022
  • [Presentation] Stress-induced NF-kB activation mediated by the nuclear IKK and cell death2012

    • Author(s)
      土谷佳弘, 金本麻裕, 菅野雅元, 浅野知一郎, 鎌田英明
    • Organizer
      35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Data Source
      KAKENHI-PROJECT-23870022
  • [Presentation] IKKβの脱リン酸化反応における転写因子RelAの関与2012

    • Author(s)
      土谷佳弘, 金本麻裕, 菅野雅元, 浅野知一郎, 鎌田英明
    • Organizer
      第85回日本生化学会合同大会ワークショップ
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-16
    • Data Source
      KAKENHI-PROJECT-23870022
  • [Presentation] IKKβ act as an adaptor protein for IκBα ubiquitination and degradation in UV-induced NF-κB activation ; possible involvement in the TNF sign aling2011

    • Author(s)
      Yoshihiro Tsuchiya
    • Organizer
      13th International TNF Conference
    • Place of Presentation
      淡路
    • Year and Date
      2011-05-17
    • Data Source
      KAKENHI-PROJECT-23870022
  • [Presentation] IKKβ act as an adaptor protein for IκBα ubiquitination and degradation in UV-induced NF-κB activation; possible involvement in the TNF signaling2011

    • Author(s)
      Yoshihiro Tsuchiya a n d H i d e a k i K a m a t a
    • Organizer
      13th International TNF Conference
    • Place of Presentation
      Awajishima
    • Year and Date
      2011-05-17
    • Data Source
      KAKENHI-PROJECT-23870022
  • [Presentation] IKKβの多重的活性制御機構ー転写因子p65 によるネガティブフィードバックとレドックス制御の関与2011

    • Author(s)
      土谷佳弘, 浅野知一郎, 菅野雅元,鎌田英明
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Data Source
      KAKENHI-PROJECT-23870022
  • [Presentation] IKKbetaの多重的活性制御機構-転写因子p65によるネガティブフィードバックとレドックス制御の関与2011

    • Author(s)
      土谷佳弘
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Data Source
      KAKENHI-PROJECT-23870022
  • [Presentation] RelA suppresses IKKb activity in a trascription-independent manner

    • Author(s)
      土谷佳弘, 浅野知一郎, 鎌田英明
    • Organizer
      第87回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25840035
  • [Presentation] RelAによる遺伝子発現非依存的なIKK活性制御機構

    • Author(s)
      土谷佳弘, 浅野知一郎, 鎌田英明
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25840035
  • 1.  KAMATA Hideaki (10233925)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 2.  NAKATSU Yusuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  浅野 知一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 4.  西村 英紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 5.  山本 雅之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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