Doki Kosuke 土岐浩介

… Alternative Names

DOKI Kosuke 土岐浩介

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Researcher Number	90620881
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 筑波大学, 医学医療系, 准教授 2014 – 2019: 筑波大学, 医学医療系, 講師 2013: 筑波大学, 附属病院, 病院講師
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 58010:Medical management and medical sociology-related
Keywords	Principal Investigator 治療薬物モニタリング / 抗体医薬品 / リポタンパク質 / アミオダロン / 薬学 / 新規経口抗凝固薬 / 直接作用型経口抗凝固薬 / 腎機能障害 / P-糖蛋白阻害薬 / 生理学的速度論モデル … More / 生理学的薬物速度論モデリング / 腎障害 / 薬物相互作用 / 血中濃度 / ダビガトラン / β１受容体 / β1受容体 / SCN5A / 有効血中濃度 / プロパフェノン / フレカイニド / 遺伝子変異 / β1アドレナリン受容体 / 遺伝子多型 / ナトリウムチャネル遮断薬 / 心筋ナトリウムチャネル … More Except Principal Investigator 肝機能障害 / 有効治療域 / 血中濃度 / TDM / エルトロンボパグ / 副作用 / PBPKモデル / 患者背景 / 出血 / 出血イベント / 大規模臨床試験 / ダビガトラン / DOAC Less

リポタンパク質結合型薬物の非結合型濃度を考慮した治療薬物モニタリング法の構築Principal Investigator
- Principal Investigator
  
  土岐浩介
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Tsukuba
Study on the practical application of TDM in eltrombopag
- Principal Investigator
  
  本間真人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Tsukuba
がん治療における抗体医薬品の治療薬物モニタリング法の構築Principal Investigator
- Principal Investigator
  
  土岐浩介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Tsukuba
大規模臨床試験データと実臨床データとの患者背景の乖離に関する研究
- Principal Investigator
  
  高嶋泰之
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  University of Tsukuba
Clinical implication of lipoprotein-binding in therapeutic drug monitoring of amiodaronePrincipal Investigator
- Principal Investigator
  
  Doki Kosuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Tsukuba
Individualized dosing of direct oral anticoagulants using blood drug concentrationPrincipal Investigator
- Principal Investigator
  
  Doki Kosuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Tsukuba
Analysis of cardiac sodium channel-related gene polymorphisms for dose adjustment of anti-arrhythmic drugsPrincipal Investigator
- Principal Investigator
  
  DOKI Kosuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Tsukuba

All 2023 2022 2021 2019 2018 2017 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Effect of massive ascites on ramucirumab pharmacokinetics in patients with gastrointestinal cancers: a population pharmacokinetic analysis2023
- Author(s)
  Kaneko Takuya、Doki Kosuke、Yamada Takeshi、Yamamoto Yoshiyuki、Moriwaki Toshikazu、Suzuki Yoshiharu、Homma Masato
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 92 Issue: 4 Pages: 271-278
- DOI
  10.1007/s00280-023-04568-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06718, KAKENHI-PROJECT-22K07272
[Journal Article] Distribution of therapeutic monoclonal antibodies into ascites in advanced gastric cancer patients with peritoneal metastasis: case reports and literature review2022
- Author(s)
  Kaneko Takuya、Doki Kosuke、Yamada Takeshi、Yamamoto Yoshiyuki、Moriwaki Toshikazu、Suzuki Yoshiharu、Homma Masato
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 90 Issue: 5 Pages: 421-426
- DOI
  10.1007/s00280-022-04479-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06718, KAKENHI-PROJECT-22K07272
[Journal Article] Increased serum amiodarone concentration in hypertriglyceridemic patients: Effects of drug distribution to serum lipoproteins2021
- Author(s)
  Hashimoto Naoaki、Doki Kosuke、Kawano Satoru、Aonuma Kazutaka、Ieda Masaki、Homma Masato
- Journal Title
  
  Clinical and Translational Science
  
  Volume: 15 Issue: 3 Pages: 771-781
- DOI
  10.1111/cts.13199
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07188
[Journal Article] Assessing Potential Drug-Drug Interactions Between Dabigatran Etexilate and a P-Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling2019
- Author(s)
  Doki Kosuke、Neuhoff Sibylle、Rostami-Hodjegan Amin、Homma Masato
- Journal Title
  
  CPT: Pharmacometrics & Systems Pharmacology
  
  Volume: 8 Issue: 2 Pages: 118-126
- DOI
  10.1002/psp4.12382
- NAID
  120007128064
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18930
[Presentation] ダビガトラン臨床試験適格基準を用いたアブレーション患者の出血リスク評価（第３報）：ダビガトランブリッジにおける出血リスク評価2023
- Author(s)
  髙嶋泰之、一水翔太、土岐浩介、本間真人
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K10368
[Presentation] 消化器癌患者における大量の腹水貯留はラムシルマブの血中濃度を低下させる2023
- Author(s)
  金子卓也、土岐浩介、山田武史、山本祥之、森脇俊和、鈴木嘉治、本間真人
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-22K06718
[Presentation] 循環器薬のTDMに関するガイドライン発刊後の新たな知見―アミオダロンを例として―2022
- Author(s)
  橋本直明、土岐浩介、本間真人
- Organizer
  第38回日本TDM学会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07188
[Presentation] ベバシズマブの腹水移行について検討した大腸癌腹膜転移の1症例2022
- Author(s)
  金子卓也, 土岐浩介, 山田武史, 新里悠輔, 本間真人
- Organizer
  第38回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-22K06718
[Presentation] ダビガトランの臨床試験適格基準を用いたアブレーション患者の出血リスク評価2022
- Author(s)
  高嶋泰之、大平美波、土岐浩介、本間真人
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K10368
[Presentation] ダビガトラン大規模臨床試験の選択/除外基準を用いたアブレーション患者の出血リスク評価（第2報）2022
- Author(s)
  髙嶋泰之、一水翔太、土岐浩介、本間真人
- Organizer
  第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K10368
[Presentation] Changes in serum amiodarone and desethylamiodarone concentrations in association with serum lipids levels2019
- Author(s)
  Naoaki Hashimoto, Kosuke Doki, Kazutaka Aonuma, Masaki Ieda, Masato Homma
- Organizer
  日本薬物動態学会　第34回年会
- Data Source
  KAKENHI-PROJECT-19K07188
[Presentation] Virtual drug-drug interaction study between dabigatran etexilate and a P-glycoprotein inhibitor in renal impairment population using physiologically-based pharmacokinetic modelling2018
- Author(s)
  Kosuke Doki, Sibylle Neuhoff, Amin Rostami-Hodjegan, Masato Homma
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18930
[Presentation] P-糖蛋白阻害薬とダビガトラン併用患者における血液凝固能と腎機能の関係（第2報）2017
- Author(s)
  横田裕之, 土岐浩介, 青沼和隆, 本間真人
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-16K18930
[Presentation] Effects of kidney function on anticoagulant effect of dabigatran in patients with co-administration of P-glycoprotein inhibitors2016
- Author(s)
  Hiroyuki Yokota, Kosuke Doki, Kazutaka Aonuma, Masato Homma
- Organizer
  第10回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  群馬大学昭和キャンパス（群馬県前橋市）
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K18930
[Presentation] フレカイニドの腎排泄におけるトランスポーターの関与2015
- Author(s)
  土岐浩介, Sandor Apati, 坂田武, 本間真人
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  京王プラザホテル新宿（東京）
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-25860106
[Presentation] プロパフェノンのTDMにおける採血時間の検討2015
- Author(s)
  土岐浩介, 白山祐輝, 関口幸夫, 久賀圭祐, 青沼和隆, 本間真人
- Organizer
  第32回日本TDM学会・学術大会
- Place of Presentation
  キッセイ文化ホール（松本）
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-25860106
[Presentation] β1-アドレナリン受容体Arg389Gly遺伝子多型がフレカイニドの治療効果におよぼす影響2013
- Author(s)
  土岐浩介、関口幸夫、久賀圭祐、青沼和隆、本間真人
- Organizer
  第34回日本臨床薬理学会年会
- Place of Presentation
  東京国際フォーラム（東京）
- Data Source
  KAKENHI-PROJECT-25860106
[Presentation] プロパフェノンのTDMにおける採血時間の検討
- Author(s)
  土岐浩介、白山祐輝、関口幸夫、久賀圭祐、青沼和隆、本間真人
- Organizer
  第32回日本TDM学会・学術大会
- Place of Presentation
  松本
- Year and Date
  2015-05-23 – 2015-05-24
- Data Source
  KAKENHI-PROJECT-25860106

1. 本間真人 (90199589)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. AONUMA KAZUTAKA

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. 高嶋泰之 (50706562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KUGA KEISUKE

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results

Doki Kosuke 土岐 浩介

DOKI Kosuke 土岐 浩介

Research Projects

Research Products

Co-Researchers

リポタンパク質結合型薬物の非結合型濃度を考慮した治療薬物モニタリング法の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the practical application of TDM in eltrombopag

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん治療における抗体医薬品の治療薬物モニタリング法の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

大規模臨床試験データと実臨床データとの患者背景の乖離に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical implication of lipoprotein-binding in therapeutic drug monitoring of amiodaronePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Individualized dosing of direct oral anticoagulants using blood drug concentrationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cardiac sodium channel-related gene polymorphisms for dose adjustment of anti-arrhythmic drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of massive ascites on ramucirumab pharmacokinetics in patients with gastrointestinal cancers: a population pharmacokinetic analysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distribution of therapeutic monoclonal antibodies into ascites in advanced gastric cancer patients with peritoneal metastasis: case reports and literature review2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased serum amiodarone concentration in hypertriglyceridemic patients: Effects of drug distribution to serum lipoproteins2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Assessing Potential Drug-Drug Interactions Between Dabigatran Etexilate and a P-Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] ダビガトラン臨床試験適格基準を用いたアブレーション患者の出血リスク評価（第３報）：ダビガトランブリッジにおける出血リスク評価2023

Author(s)

Organizer

Data Source

[Presentation] 消化器癌患者における大量の腹水貯留はラムシルマブの血中濃度を低下させる2023

Author(s)

Organizer

Data Source

[Presentation] 循環器薬のTDMに関するガイドライン発刊後の新たな知見―アミオダロンを例として―2022

Author(s)

Organizer

Data Source

Doki Kosuke 土岐浩介

DOKI Kosuke 土岐浩介