Izawa Kazushi 井澤和司

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IZAWA Kazushi 井澤和司

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Researcher Number	90634931
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help	2025: 京都大学, 医学研究科, 講師 2023: 京都大学, 医学研究科, 講師 2016 – 2022: 京都大学, 医学研究科, 助教 2016: 京都大学, 大学院医学研究科発達小児科学, 助教 2012 – 2013: 京都大学, 医学(系)研究科(研究院), 医員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Keywords	Principal Investigator 自己炎症性疾患 / 体細胞モザイク / クリオピリン関連周期熱症候群 / 発現解析 / インターフェロン / 自己免疫疾患 / Ⅰ型インターフェロン / NLRC4 / NLRP3 / インフラマソーム … More / MEFV / 家族性地中海熱 / NLRC4異常症 / 医療 / 遺伝子診断 / 遺伝子 / 遺伝子重複 / 遺伝子欠失 / 分子バーコード / モザイク変異 / 遺伝子変異 / 炎症 / サイトカイン … More Except Principal Investigator iPS細胞 / 自己炎症性疾患 / オミックス解析 / マルチオミックス解析 / 自己炎症症候群 / マクロファージ / iPS細胞由来細胞株 / 疾患特異的iPS細胞 / TNF受容体関連周期性症候群 / iPS-ML / TRAPS / 自己炎症性症候群 / TNF受容体関連症候群 / 単球、マクロファージ / CAPS / 自己炎症疾患 / 軟骨細胞 / 単球・マクロファージ / モザイシズム / 病態解明 / インフラマソーム Less

クリオピリン関連周期熱症候群における体細胞モザイク変異の推移と炎症機序の解明Principal Investigator
- Principal Investigator
  
  井澤和司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto University
原因不明の炎症性疾患におけるⅠ型IFN応答遺伝の発現解析と新規炎症病態の解明Principal Investigator
- Principal Investigator
  
  井澤和司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto University
Elucidation of molecular mechanism of TNF receptor-associated periodic syndrome by cell technology and multi-omics analysis
- Principal Investigator
  
  Nishikomori Ryuta
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Mechanisms of caspase-1-independent cell death induced by NLRP3 and NLRC4 disease-associated variantsPrincipal Investigator
- Principal Investigator
  
  Izawa Kazushi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto University
Detection of Low frequent mosaism in autoinflammatory diseases using molecular barcode methodPrincipal Investigator
- Principal Investigator
  
  Izawa Kazushi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Establishing a platform for molecular analysis and drug innovation of auto-inflammatory disorders
- Principal Investigator
  
  Heike Toshio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Elucidation of molecular mechanisms of NLRP3 mosaicismPrincipal Investigator
- Principal Investigator
  
  IZAWA Kazushi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University

All 2022 2021 2020 2019 2018 2017 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 【自己炎症性疾患における最近の展開】自己炎症性疾患の診療ガイドライン2019
- Author(s)
  井澤和司(京都大学大学院医学研究科発達小児科学), 西小森隆太
- Total Pages
  3
- Publisher
  先端医学社
- ISBN
- Data Source
  KAKENHI-PROJECT-16K19640
[Book] 【小児疾患の診断治療基準】 (第2部)疾患　アレルギー性疾患、自己免疫・リウマチ性疾患(膠原病)　自己炎症症候群2018
- Author(s)
  西小森隆太(京都大学大学院医学研究科発達小児科学), 井澤和司
- Total Pages
  3
- Publisher
  東京医学社
- ISBN
- Data Source
  KAKENHI-PROJECT-16K19640
[Book] 【自己炎症性疾患-最新の基礎・臨床知見-】狭義の自己炎症性疾患　アデノシンデアミナーゼ-2(ADA2)欠損症2018
- Author(s)
  井澤和司(京都大学医学部附属病院小児科), 仁平寛士, 西小森隆太
- Total Pages
  5
- Publisher
  日本臨床社
- ISBN
- Data Source
  KAKENHI-PROJECT-16K19640
[Book] 【自己炎症性疾患-最新の基礎・臨床知見-】狭義の自己炎症性疾患　インターロイキンI受容体拮抗分子欠損症、NLRP12関連周期熱症候群、H症候群2018
- Author(s)
  柴田洋史(京都大学大学院医学研究科発達小児科学講座), 井澤和司, 西小森隆太
- Total Pages
  6
- Publisher
  日本臨床社
- ISBN
- Data Source
  KAKENHI-PROJECT-16K19640
[Book] 【自己炎症性疾患-病態解明から診療体制の確立まで】病態解明・治療法確立にむけての新展開　アデノシンデアミナーゼ-2(ADA2)欠損症2018
- Author(s)
  井澤和司(京都大学医学部附属病院小児科), 仁平寛士, 西小森隆太
- Total Pages
  5
- Publisher
  医歯薬出版
- ISBN
- Data Source
  KAKENHI-PROJECT-16K19640
[Book] 【自己炎症性疾患-最新の基礎・臨床知見-】狭義の自己炎症性疾患　蕁麻疹様皮疹を伴う自己炎症性疾患　ホスホリパーゼCγ2関連抗体欠損・免疫異常症(PLAID)、Schnitzler症候群など2018
- Author(s)
  本田吉孝(京都大学大学院医学研究科発達小児科学), 井澤和司, 西小森隆太
- Total Pages
  6
- Publisher
  日本臨床社
- ISBN
- Data Source
  KAKENHI-PROJECT-16K19640
[Book] 自己炎症性疾患・自然免疫不全症とその近縁疾患（CAPSの項）2012
- Author(s)
  井澤和司
- Total Pages
  280
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-24890096
[Journal Article] Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience.2022
- Author(s)
  Miyamoto T, Honda Y, Izawa K, Kanazawa N, Saito MK, Takita J, Nishikomori R, Yasumi T, et al.
- Journal Title
  
  Front Immunol
  
  Volume: 13 Pages: 905960-905960
- DOI
  10.3389/fimmu.2022.905960
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08798, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-22K06999, KAKENHI-PROJECT-22K07829, KAKENHI-PROJECT-22K07867, KAKENHI-PROJECT-19K08754, KAKENHI-PROJECT-23K24302
[Journal Article] Hematopoietic Cell Transplantation Ameliorates Autoinflammation in A20 Haploinsufficiency2021
- Author(s)
  Shiraki, M. Williams, E. Yokoyama, N. Shinoda, K. Nademi, Z. Matsumoto, K. Nihira, H. Honda, Y. Izawa, K. Nishikomori, R. Slatter, M. A. Cant, A. J. Gennery, A. R. Ohnishi, H. Kanegane, H.
- Journal Title
  
  J Clin Immunol
  
  Volume: 41 Issue: 8 Pages: 1954-1956
- DOI
  10.1007/s10875-021-01124-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-21K07770
[Journal Article] Detailed analysis of Japanese patients with adenosine deaminase 2 deficiency reveals characteristic elevation of type II interferon signature and STAT1 hyperactivation.2021
- Author(s)
  Nihira H, Izawa K, Ito M, Umebayashi H, Okano T, Kajikawa S, Nanishi E, Keino D, Murakami K, Isa-Nishitani M, Shiba T, Honda Y, Hijikata A, Yasu T, Kubota T, Hasegawa Y, Kawashima Y, Nakano N, Takada H, Ohga S, Heike T, Takita J, Ohara O, Takei S, Takahashi M, Kanegane H, Morio T,etc
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: Jan 30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17293
[Journal Article] Augmentation of STING‐induced type I interferon production in COPA syndrome2021
- Author(s)
  Kato Takashi、Yamamoto Masaki、Honda Yoshitaka、Orimo Takashi、Sasaki Izumi、Murakami Kohei、Hemmi Hiroaki、Fukuda‐Ohta Yuri、Isono Kyoichi、Takayama Saki、Nakamura Hidenori、Otsuki Yoshiro、Miyamoto Toshiaki、Takita Junko、Yasumi Takahiro、Nishikomori Ryuta、Matsubayashi Tadashi、Izawa Kazushi、Kaisho Tsuneyasu
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: in press Issue: 11 Pages: 2105-2115
- DOI
  10.1002/art.41790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-18K16096, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20K16289, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-21J22615, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K09216, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-21K19405
[Journal Article] Detailed analysis of Japanese patients with adenosine deaminase 2 deficiency reveals characteristic elevation of type II interferon signature and STAT1 hyperactivation.2021
- Author(s)
  Nihira H, Izawa K, Ito M, Umebayashi H, Okano T, Kajikawa S, ...Yasumi T.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 印刷中 Issue: 2 Pages: 00157-3
- DOI
  10.1016/j.jaci.2021.01.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16355, KAKENHI-PROJECT-19H03613, KAKENHI-PROJECT-18K18154, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-21K19405
[Journal Article] Rapid Flow Cytometry-Based Assay for the Functional Classification of MEFV Variants2021
- Author(s)
  Honda Y, Maeda Y, Izawa K, Shiba T, Tanaka T, Nakaseko H, Nishimura K, Mukoyama H, Isa-Nishitani M, Miyamoto T, Nihira H, Shibata H, Hiejima E, Ohara O, Takita J, Yasumi T, Nishikomori R.
- Journal Title
  
  J Clin Immunol.
  
  Volume: Online ahead of print. Issue: 6 Pages: 1187-1197
- DOI
  10.1007/s10875-021-01021-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16852, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-19K08320, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-21K19405
[Journal Article] Rapid Flow Cytometry-Based Assay for the Functional Classification of MEFV Variants2021
- Author(s)
  Honda Y, Maeda Y, Izawa K, Shiba T, Tanaka T, Nakaseko H, Nishimura K, Mukoyama H, Isa-Nishitani M, Miyamoto T, Nihira H, Shibata H, Hiejima E, Ohara O, Takita J, Yasumi T, Nishikomori R.
- Journal Title
  
  J Clin Immunol.
  
  Volume: Mar 17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17293
[Journal Article] Immunophenotyping of A20 haploinsufficiency by multicolor flow cytometry2020
- Author(s)
  Kadowaki, T. Ohnishi, H. Kawamoto, N. Kadowaki, S. Hori, T. Nishimura, K. Kobayashi, C. Shigemura, T. Ogata, S. Inoue, Y. Hiejima, E. Izawa, K. Matsubayashi, T. Matsumoto, K. Imai, K. Nishikomori, R. Ito, S. Kanegane, H. Fukao, T.
- Journal Title
  
  Clinical Immunology
  
  Volume: 216 Pages: 108441-108441
- DOI
  10.1016/j.clim.2020.108441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20K16852, KAKENHI-PROJECT-18K07814
[Journal Article] Haploinsufficiency of A20 with a novel mutation of deletion of exons 2-3 of TNFAIP3.2020
- Author(s)
  Shimizu Maho、Matsubayashi Tadashi、Ohnishi Hidenori、Nakama Mina、Izawa Kazushi、Honda Yoshitaka、Nishikomori Ryuta
- Journal Title
  
  Modern Rheumatology
  
  Volume: e-pub Issue: 2 Pages: 1-5
- DOI
  10.1080/14397595.2020.1719595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07840, KAKENHI-PROJECT-19K17293, KAKENHI-PROJECT-19K08299
[Journal Article] Aicardi-Goutieres syndrome-like encephalitis in mutant mice with constitutively active MDA52020
- Author(s)
  Onizawa Hideo、Kato Hiroki、Kimura Hiroyuki、Kudo Tomoo、Soda Nobumasa、Shimizu Shota、Funabiki Masahide、Yagi Yusuke、Nakamoto Yuji、Priller Josef、Nishikomori Ryuta、Heike Toshio、Yan Nan、Tsujimura Tohru、Mimori Tsuneyo、Fujita Takashi
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 4 Pages: 225-240
- DOI
  10.1093/intimm/dxaa073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15566, KAKENHI-PROJECT-19K08299
[Journal Article] Functional evaluation of the pathological significance of MEFV variants using induced pluripotent stem cell-derived macrophages2019
- Author(s)
  Shiba, T. Tanaka, T. Ida, H. Watanabe, M. Nakaseko, H. Osawa, M. Shibata, H. Izawa, K. Yasumi, T. Kawasaki, Y. Saito, M. K. Takita, J. Heike, T. Nishikomori, R.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 144 Issue: 5 Pages: 1438-1441
- DOI
  10.1016/j.jaci.2019.07.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-19K17293, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-18K19467, KAKENHI-PROJECT-19K08320
[Journal Article] Expanding clinical spectrum of autosomal dominant pyrin-associated autoinflammatory disorder caused by the heterozygous MEFV p.Thr577Asn variant2019
- Author(s)
  Nakaseko, H. Iwata, N. Izawa, K. Shibata, H. Yasuoka, R. Kohagura, T. Abe, N. Kawabe, S. Nishikomori, R.
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 58 Pages: 182-184
- DOI
  10.1093/rheumatology/key283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08299
[Journal Article] Expanding clinical spectrum of autosomal dominant pyrin-associated autoinflammatory disorder caused by the heterozygous MEFV p.Thr577Asn variant.2019
- Author(s)
  Nakaseko H, Iwata N, Izawa K, Shibata H, Yasuoka R, Kohagura T, Abe N, Kawabe S, Nishikomori R.
- Journal Title
  
  Rheumatology (Oxford).
  
  Volume: 1;58(1) Pages: 182-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19640
[Journal Article] Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells.2019
- Author(s)
  3.Rodriguez R, Fournier B, Cordeiro DJ, Winter S, Izawa K, Martin E, Boutboul D, Lenoir C, Fraitag S, Kracker S, Watts TH, Picard C, Bruneau J, Callebaut I, Fischer A, Neven B, Latour S.
- Journal Title
  
  J Exp Med.
  
  Volume: Dec 2;216(12) Issue: 12 Pages: 2800-2818
- DOI
  10.1084/jem.20190678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17293
[Journal Article] Low-frequency mosaicism in cryopyrin-associated periodic fever syndrome: mosaicism in systemic autoinflammatory diseases2019
- Author(s)
  Nishikomori, R. Izawa, K. Kambe, N. Ohara, O. Yasumi, T.
- Journal Title
  
  Int Immunol
  
  Volume: 31 Issue: 10 Pages: 649-655
- DOI
  10.1093/intimm/dxz047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-19K08784, KAKENHI-PROJECT-19K17293
[Journal Article] Plasma infliximab monitoring contributes to optimize Takayasu arteritis treatment: a case report.2019
- Author(s)
  5.Masui S, Yonezawa A, Izawa K, Hayakari M, Asakura K, Taniguchi R, Isa M, Shibata H, Yasumi T, Nishikomori R, Takita J, Matsubara K.
- Journal Title
  
  J Pharm Health Care Sci.
  
  Volume: May 2;5:9 Issue: 1 Pages: 9-9
- DOI
  10.1186/s40780-019-0136-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17293, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-19H03389, KAKENHI-PROJECT-18K19467
[Journal Article] Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency.2019
- Author(s)
  Boisson B, Honda Y, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, et al.
- Journal Title
  
  J Clin Invest.
  
  Volume: 1;129(2) Pages: 583-597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19640
[Journal Article] Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing.2018
- Author(s)
  Ono S, Nakayama M, Kanegane H, Hoshino A, Shimodera S, Shibata H, Fujino H, Fujino T, Yunomae Y, Okano T, Yamashita M, Yasumi T, Izawa K, Takagi M, Imai K, Zhang K, Marsh R, Picard C, Latour S, Ohara O, Morio T.
- Journal Title
  
  Int J Hematol.
  
  Volume: 108(3) Pages: 319-328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19640
[Journal Article] Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis.2018
- Author(s)
  Shibata H, Yasumi T, Shimodera S, Hiejima E, Izawa K, Kawai T, Shirakawa R, Wada T, Nishikomori R, Horiuchi H, Ohara O, Ishii E, Heike T.
- Journal Title
  
  Blood.
  
  Volume: 3;131(18) Pages: 2016-2025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19640
[Journal Article] Characterization of a large UNC13D gene duplication in a patient with familial hemophagocytic lymphohistiocytosis type 3.2018
- Author(s)
  Hiejima E, Shibata H, Yasumi T, Shimodera S, Hori M, Izawa K, Kawai T, Matsuoka M, Kojima Y, Ohara A, Nishikomori R, Ohara O, Heike T.
- Journal Title
  
  Clin Immunol.
  
  Volume: 191 Pages: 63-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19640
[Journal Article] Accurate clinical genetic testing for autoinflammatory diseases using the next-generation sequencing platform MiSeq2017
- Author(s)
  Nakayama Manabu、Oda Hirotsugu、Nakagawa Kenji、Yasumi Takahiro、Kawai Tomoki、Izawa Kazushi、Nishikomori Ryuta、Heike Toshio、Ohara Osamu
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 9 Pages: 146-152
- DOI
  10.1016/j.bbrep.2016.12.002
- NAID
  120006355733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19640, KAKENHI-PROJECT-15H04876
[Journal Article] Fever of unknown origin with rashes in early infancy is indicative of adenosine deaminase type 2 deficiency2017
- Author(s)
  Nihira H、Nakagawa K、Izawa K、Kawai T、Yasumi T、Nishikomori R、Nambu M、Miyagawa-Hayashino A、Nomura T、Kabashima K、Ito M、Iwaki-Egawa S、Sasahara Y、Nakayama M、Heike T
- Journal Title
  
  Scandinavian Journal of Rheumatology
  
  Volume: 47 Issue: 2 Pages: 170-172
- DOI
  10.1080/03009742.2017.1324912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19640, KAKENHI-PROJECT-15H04876
[Journal Article] Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway2015
- Author(s)
  Yokoyama, K. Ikeya, M. Umeda, K. Oda, H. Nodomi, S. Nasu, A. Matsumoto, Y. Izawa, K. Horigome, K. Kusaka, T. Tanaka, T. Saito, M. K. Yasumi, T. Nishikomori, R. Ohara, O. Nakayama, N. Nakahata, T. Heike, T. Toguchida, J.
- Journal Title
  
  Arthritis Rheumatol
  
  Volume: 67 Issue: 1 Pages: 302-314
- DOI
  10.1002/art.38912
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24591507, KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26253062, KAKENHI-PROJECT-26670498, KAKENHI-PROJECT-15K15549
[Journal Article] Real-time single-cell imaging of protein secretion2014
- Author(s)
  Shirasaki Y, Yamagishi M, Suzuki N, Izawa K, Nakahara A, Mizuno J, Shoji S, Heike T, Harada Y, Nishikomori R, Ohara O
- Journal Title
  
  scientific reports
  
  Volume: 4 Pages: 4736-4736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890096
[Journal Article] Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.2014
- Author(s)
  Nakagawa K, Kawai T, Umebayashi H, Takei S, Kobayashi N, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI et al.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: in press Issue: 3 Pages: 1-8
- DOI
  10.1136/annrheumdis-2013-204361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249056, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24590681, KAKENHI-PROJECT-25460838, KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26253062
[Journal Article] Real-time single-cell imaging of protein secretion2014
- Author(s)
  Yoshitaka Shirasaki, Mai Yamagishi, Nobutake Suzuki, Kazushi Izawa, Asahi Nakahara, Jun Mizuno, Shuichi Shoji, Toshio Heike, Yoshie Harada Ryuta Nishikomori, and Osamu Ohara
- Journal Title
  
  Scientific Reports
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890096
[Journal Article] Heterozygous TREX1 p.Asp18Asn mutation can cause variable neurological symptoms in a family with Aicardi-Goutieres syndrome/familial chilblain lupus2013
- Author(s)
  Abe J, Izawa K, Nishikomori R, Awaya T, Kawai T, Yasumi T, Hiragi N, Hiragi T, Ohshima Y, Heike T
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 52(2) Pages: 406-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890096
[Journal Article] Autosomal dominant anhidrotic ectodermal dysplasia with immunodeficiency caused by a novel NFKBIA mutation, p.Ser36Tyr, presents with mild ectodermal dysplasia and non-infectious systemic inflammation2013
- Author(s)
  Yoshioka T, Nishikomori R, Hara J, Okada K, Hashii Y, Okafuji I, Nodomi S, Kawai T, Izawa K, Ohnishi H, Yasumi T, Nakahata T, Heike T
- Journal Title
  
  J Clin Immunol.
  
  Volume: 33(7) Pages: 1165-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890096
[Journal Article] A nationwide survey of Aicardi-Goutieres syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions : Japanese cohort study
- Author(s)
  Abe J, Nakamura K, Nishikomori R, Kato M, Mitsuiki N, Izawa K, Awaya T, Kawai T, Yasumi T, Toyoshima I, Hasegawa K, Ohshima Y, Hiragi T, Sasahara Y, Suzuki Y, Kikuchi M, Osaka H, Ohya T, Ninomiya S, Fujikawa S, Akasaka M, Iwata N, Kawakita A, Funatsuka M, Shintaku H, Ohara O, Ichinose H, Heike T
- Journal Title
  
  Rheumatology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890096
[Journal Article] Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes
- Author(s)
  Nakagawa K, Gonzalez-Roca E, Souto A, Kawai T, Umebayashi H, Campistol JM, Cañellas J, Takei S, Kobayashi N, Callejas-Rubio JL, Ortego-Centeno N, Ruiz-Ortiz E, Rius F, Anton J, Iglesias E, Jimenez-Treviño S, Vargas C, Fernandez-Martin J, Calvo I, Hernández-Rodríguez J, Mendez M, Dordal MT, Basagaña M, Bujan S, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890096
[Presentation] インターフェロノパチーの最新知見2022
- Author(s)
  井澤
- Organizer
  第54回日本小児感染症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07867
[Presentation] 新規機能解析系によるMEFVバリアントの病原性評価・分類の試み2021
- Author(s)
  前田由可子、本田吉孝、井澤和司、芝剛、田中孝之、中瀬古春奈、西村啓佑、向山宙希、東口素子、加藤健太郎、宮本尚幸、伊佐（西谷）真彦、仁平寛士1)、柴田洋史、日衛嶋栄太郎、小原收、滝田順子、八角高裕、西小森隆太
- Organizer
  第4回日本免疫不全・自己炎症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17293
[Presentation] 新規機能解析系によるMEFVバリアントの病原性評価・分類の試み2020
- Author(s)
  前田由可子, 本田吉孝, 井澤和司, 芝剛, 田中孝之, 東口素子, 加藤健太郎, 宮本尚幸, 伊佐真彦[西谷], 仁平寛士, 柴田洋史, 日衛嶋栄太郎, 滝田順子, 西小森隆太
- Organizer
  第48回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K17293
[Presentation] 免疫疾患の遺伝的背景　新規機能解析系によるMEFVバリアントの病原性評価・分類の試み.2020
- Author(s)
  前田由可子, 本田吉孝, 井澤和司, 芝剛, 田中孝之, 東口素子, 加藤健太郎, 宮本尚幸, 伊佐真彦[西谷], 仁平寛士, 柴田洋史, 日衛嶋栄太郎, 滝田順子, 西小森隆太.
- Organizer
  第43回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K08299
[Presentation] A case report of Hermansky-Pudlak type 2 in comparison with Hermansky-Pudlak type 1 in onePID center.2020
- Author(s)
  西小森隆太, 渡邊順子, 田中征治, 島さほ, 北城恵史郎, 水落建輝, 石原潤, 柴田洋史, 八角高裕, 井澤和司, 岡村賢, 林昌弘, 鈴木民夫, 田代克弥, 冨野広通, 江頭智子, 高柳俊光, 山下裕史朗.
- Organizer
  第3回日本免疫不全・自己炎症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08299
[Presentation] 4.免疫不全原発性免疫不全症の遺伝子診断におけるExome解析のpitfallと診断困難例に対する解析戦略患者由来iPS細胞を用いて診断したDeep intron変異による細胞種依存的なNEMO異常症の経験から2019
- Author(s)
  本田吉孝,八角高裕,伊佐真彦,仁平寛士,芝剛,柴田洋史,田中孝之,井澤和司,川崎ゆり,齋藤潤,網代将彦,萩原正敏,岡田賢,小原收,平家俊男,滝田順子,西小森隆太
- Organizer
  第47回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-19K17293
[Presentation] 3.多彩な自己炎症性疾患を紐解くインフラマソームを介した自己炎症性疾患の診断・治療にiPS細胞がどのように役立つか?2019
- Author(s)
  田中孝之,芝剛,西小森隆太,柴田洋史,井澤和司,柳町昌克,齋藤潤,中畑龍俊,小原收,平家俊男,滝田順子,八角高裕,
- Organizer
  第29回日本小児リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K17293
[Presentation] 1.不明熱診療における末梢血1型インターフェロン応答遺伝子群の発現解析の有用性,2019
- Author(s)
  宮本尚幸,本田吉孝,井澤和司,前田由可子,西谷真彦,仁平寛,柴田洋史,田中孝之,八角高裕,滝田順子,西小森隆太
- Organizer
  第29回日本小児リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K17293
[Presentation] 2.MEFV V726A/I692del複合ヘテロ接合性変異を認め、自己免疫性肝炎を併発した家族性地中海熱の一例2019
- Author(s)
  宮本尚幸,井澤和司,田中孝之,前田由可子,西谷真彦,仁平寛士,本田吉孝,柴田洋史,八角高裕,滝田順子,西小森隆太
- Organizer
  第29回日本小児リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K17293
[Presentation] 意義不明なMEFV遺伝子の変異/SNPが疾患発症に関連するかの評価系の検討2018
- Author(s)
  田中孝之, 芝剛, 西小森隆太, 井田弘明, 柴田洋史, 井澤和司, 八角高裕, 齋藤潤, 平家俊男
- Organizer
  日本小児リウマチ学会総会・学術集会プログラム・抄録集28回 Page86(2018.10)
- Data Source
  KAKENHI-PROJECT-16K19640
[Presentation] 患者由来iPS細胞を用いた家族性地中海熱の病態解明2018
- Author(s)
  田中孝之, 西小森隆太, 井田弘明, 柴田洋史, 井澤和司, 河合朋樹, 八角高裕, 齋藤潤, 平家俊男
- Organizer
  日本小児科学会雑誌(0001-6543)122巻2号 Page255(2018.02)
- Data Source
  KAKENHI-PROJECT-16K19640
[Presentation] Self-limitedであったNLRC4の新規SNP変異を持つ女児例2018
- Author(s)
  楠田政輝, 井澤和司, 山崎雄一, 久保田知洋, 野中由希子, 嶽崎智子, 今中啓之, 武井修治, 山遠剛, 芝剛, 西小森隆太, 平家俊男, 河野嘉文
- Organizer
  日本小児リウマチ学会総会・学術集会プログラム・抄録集28回 Page71(2018.10)
- Data Source
  KAKENHI-PROJECT-16K19640
[Presentation] 本邦におけるAdenosine Deaminase 2欠損症の臨床的および遺伝学的解析2018
- Author(s)
  笹原洋二, 井澤和司, 梅林宏明, 中野直子, 金兼弘和, 森尾友宏, 平家俊男, 呉繁夫
- Organizer
  日本小児科学会雑誌(0001-6543)122巻2号 Page255(2018.02)
- Data Source
  KAKENHI-PROJECT-16K19640
[Presentation] 自己炎症症候群インフリキシマブが二次無効となったADA2欠損症の乳児例2018
- Author(s)
  山田早紀, 井澤和司, 西谷真彦, 仁平寛士, 柴田洋史, 田中孝之, 河合朋樹, 八角高裕, 西小森隆太
- Organizer
  日本リウマチ学会総会・学術集会プログラム・抄録集62回 Page461(2018.03)
- Data Source
  KAKENHI-PROJECT-16K19640
[Presentation] 反復性高サイトカイン血症、慢性炎症を呈したKARS遺伝子異常症の1例2018
- Author(s)
  仁平寛士, 井澤和司, 伊佐真彦, 芝剛, 本田吉孝, 下寺佐栄子, 柴田洋史, 田中孝之, 八角高裕, 矢野直子, 舞鶴賀奈子, 吉田健司, 横山淳史, 村山圭, 小原収, 西小森隆太
- Organizer
  日本小児リウマチ学会総会・学術集会プログラム・抄録集28回 Page73(2018.10)
- Data Source
  KAKENHI-PROJECT-16K19640
[Presentation] Early Diagnosis of an Infant with DADA2-Japanese Cohort2018
- Author(s)
  Kazushi Izawa, Hiroshi Nihira, Takahiro Yasumi, Ryuta Nishikomori
- Organizer
  The Second International Conference on Deficiency of ADA2
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19640
[Presentation] gene expression and signaling in the immune system2014
- Author(s)
  Yoshitaka Shirasaki, Mai Yamagishi, Kazushi Izawa Hirotsugu Oda, Toshio Heike, Ryuta Nishikomori, Osamu Ohara
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-24890096
[Presentation] Real-time single-cell imaging of IL-1β secretion by Inflammasomes2014
- Author(s)
  Yoshitaka Shirasaki, Mai Yamagishi, Kazushi Izawa, Hirotsugu Oda, Toshio Heike, Ryuta Nishikomori, Osamu Ohara
- Organizer
  Gene Expression&Signaling in the Immune System meeting
- Place of Presentation
  New York
- Data Source
  KAKENHI-PROJECT-24890096
[Presentation] Muckle-Wells症候群におけるNLRP3体細胞モザイク変異の検討2013
- Author(s)
  中川権史, 西小森隆太, 井澤和司, 河合朋樹, 八角高裕, 河合利尚, 梅林宏明, 武井修治, 小林法元, 小原收, Eva Gonzalez-Roca, Juan I. Arostegui, 平家俊男
- Organizer
  第41回日本臨床免疫学会
- Place of Presentation
  下関
- Year and Date
  2013-11-27
- Data Source
  KAKENHI-PROJECT-24890096
[Presentation] Muckle-Wells症候群におけるNLRP3体細胞モザイク変異の検討2013
- Author(s)
  中川権史, 西小森隆太, 井澤和司, 河合朋樹, 八角高裕, 河合利尚, 梅林宏明, 武井修治, 小林法元, 小原收, Eva Gonzalez-Roca, Juan I. Arostegui, 平家俊男
- Organizer
  第23回日本小児リウマチ学会
- Place of Presentation
  埼玉
- Year and Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-24890096
[Presentation] CAPSに対するアナキンラ治療の有効性及び安全性の後方視的検討2013
- Author(s)
  中川権史, 井澤和司, 西小森隆太, 河合朋樹, 八角高裕, 津下充, 小林法元, 河島尚志, 谷口敦夫, 窪田哲朗, 松林正, 平家俊男
- Organizer
  第57回日本リウマチ学会
- Place of Presentation
  京都
- Year and Date
  2013-04-18
- Data Source
  KAKENHI-PROJECT-24890096

1. Nishikomori Ryuta (70359800)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. Heike Toshio (90190173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 八角高裕 (00511891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 小原收 (20370926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 河合朋樹 (20631568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 斎藤潤 (90535486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Hiejima Eitaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 戸田口淳也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 改正恒康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 金澤伸雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 伊藤萌子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 大西秀典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 屋木祐亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 神戸直智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Izawa Kazushi 井澤 和司

IZAWA Kazushi 井澤 和司

Research Projects

Research Products

Co-Researchers

クリオピリン関連周期熱症候群における体細胞モザイク変異の推移と炎症機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

原因不明の炎症性疾患におけるⅠ型IFN応答遺伝の発現解析と新規炎症病態の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanism of TNF receptor-associated periodic syndrome by cell technology and multi-omics analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of caspase-1-independent cell death induced by NLRP3 and NLRC4 disease-associated variantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Detection of Low frequent mosaism in autoinflammatory diseases using molecular barcode methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishing a platform for molecular analysis and drug innovation of auto-inflammatory disorders

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of molecular mechanisms of NLRP3 mosaicismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 【自己炎症性疾患における最近の展開】 自己炎症性疾患の診療ガイドライン2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 【小児疾患の診断治療基準】 (第2部)疾患 アレルギー性疾患、自己免疫・リウマチ性疾患(膠原病) 自己炎症症候群2018

Author(s)

Total Pages

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[Book] 【自己炎症性疾患-最新の基礎・臨床知見-】 狭義の自己炎症性疾患 アデノシンデアミナーゼ-2(ADA2)欠損症2018

Author(s)

Total Pages

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Data Source

[Book] 【自己炎症性疾患-最新の基礎・臨床知見-】 狭義の自己炎症性疾患 インターロイキンI受容体拮抗分子欠損症、NLRP12関連周期熱症候群、H症候群2018

Author(s)

Total Pages

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ISBN

Data Source

[Book] 【自己炎症性疾患-病態解明から診療体制の確立まで】 病態解明・治療法確立にむけての新展開 アデノシンデアミナーゼ-2(ADA2)欠損症2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 【自己炎症性疾患-最新の基礎・臨床知見-】 狭義の自己炎症性疾患 蕁麻疹様皮疹を伴う自己炎症性疾患 ホスホリパーゼCγ2関連抗体欠損・免疫異常症(PLAID)、Schnitzler症候群など2018

Author(s)

Total Pages

Izawa Kazushi 井澤和司

IZAWA Kazushi 井澤和司

[Book] 【自己炎症性疾患における最近の展開】自己炎症性疾患の診療ガイドライン2019

[Book] 【小児疾患の診断治療基準】 (第2部)疾患　アレルギー性疾患、自己免疫・リウマチ性疾患(膠原病)　自己炎症症候群2018

[Book] 【自己炎症性疾患-最新の基礎・臨床知見-】狭義の自己炎症性疾患　アデノシンデアミナーゼ-2(ADA2)欠損症2018

[Book] 【自己炎症性疾患-最新の基礎・臨床知見-】狭義の自己炎症性疾患　インターロイキンI受容体拮抗分子欠損症、NLRP12関連周期熱症候群、H症候群2018

[Book] 【自己炎症性疾患-病態解明から診療体制の確立まで】病態解明・治療法確立にむけての新展開　アデノシンデアミナーゼ-2(ADA2)欠損症2018

[Book] 【自己炎症性疾患-最新の基礎・臨床知見-】狭義の自己炎症性疾患　蕁麻疹様皮疹を伴う自己炎症性疾患　ホスホリパーゼCγ2関連抗体欠損・免疫異常症(PLAID)、Schnitzler症候群など2018