Monai Hiromu 毛内拡

Researcher Number	90708413
Other IDs	https://orcid.org/0000-0002-6975-7218
Affiliation (Current)	2025: お茶の水女子大学, 基幹研究院, 助教
Affiliation (based on the past Project Information) *help	2025: お茶の水女子大学, 基幹研究院, 助教 2018 – 2022: お茶の水女子大学, 基幹研究院, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 46010:Neuroscience-general-related / Basic Section 46030:Function of nervous system-related Except Principal Investigator Sections That Are Subject to Joint Review: Basic Section60030:Statistical science-related , Basic Section61030:Intelligent informatics-related / Basic Section 60030:Statistical science-related / Basic Section 61030:Intelligent informatics-related / Basic Section 47040:Pharmacology-related
Keywords	Principal Investigator アドレナリン受容体 / アストロサイト / 光血栓法 / 脳脊髄液 / アクアポリン4 / 脳梗塞 / 腸管グリア / ADRA1A / GFAP / 細胞間質液 … More / ミクログリア / マウス / 大脳皮質 / 脳脊髄液循環 / 水チャネル (AQP4) / アクアポリン / 細胞外カリウムイオン / 阻害薬 / ノルアドレナリン / カリウムイオン / 脳脊髄液（髄液） … More Except Principal Investigator 情報圧縮 / フラクタル / 海馬 / 文脈学習 / 時空間学習則 / 生理活性脂質 / テネイシンC / 代謝物 / 神経細胞 / アストロサイト / ミクログリア / 脳血管障害 / 環状ホスファチジン酸 Less

Understanding Top-Down Mechanisms in the Dynamics of Contextual Memory and Learning
- Principal Investigator
  
  塚田啓道
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 61030:Intelligent informatics-related
  Basic Section 60030:Statistical science-related
  Sections That Are Subject to Joint Review: Basic Section60030:Statistical science-related , Basic Section61030:Intelligent informatics-related
- Research Institution
  Chubu University
アストロサイトにヒト特異的遺伝的変異を導入した遺伝子改変マウスの生理機能解析Principal Investigator
- Principal Investigator
  
  毛内拡
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Ochanomizu University
The mechanisms of the dysregulation of brain water channel aquaporin 4 (AQP4) after acute ischemic stroke in mice brainPrincipal Investigator
- Principal Investigator
  
  Monai Hiromu
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Ochanomizu University
A novel mechanism of bioactive lipids with neuroprotective effects: application for treatment of cerebrovascular disease
- Principal Investigator
  
  GOTOH Mari
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Teikyo University
  Ochanomizu University
The mechanisms of extracellular ion homeostasis by brain fluid dynamicsPrincipal Investigator
- Principal Investigator
  
  Monai Hiromu
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  Ochanomizu University

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] 脳を司る「脳」　最新研究で見えてきた、驚くべき脳のはたらき2020
- Author(s)
  毛内拡
- Total Pages
  272
- Publisher
  講談社
- ISBN
  9784065219195
- Data Source
  KAKENHI-PROJECT-20K15895
[Book] 脳の半分を占める　グリア細胞2019
- Author(s)
  平瀬肇, 王筱文, 毛内拡, 安井正人
- Total Pages
  230
- Publisher
  羊土社
- ISBN
  9784758103824
- Data Source
  KAKENHI-PROJECT-18K14859
[Journal Article] Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization2021
- Author(s)
  H Monai, S Koketsu, Y Shinohara, T Ueki, P Kusk, Hauglund, NL, Samson AJ, Nedergaard M, Hirase H
- Journal Title
  
  Sci Rep
  
  Volume: 11(1) Issue: 1 Pages: 8150-8160
- DOI
  10.1038/s41598-021-87609-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02221, KAKENHI-PROJECT-19K22594, KAKENHI-PROJECT-20K15895, KAKENHI-PLANNED-16H06404, KAKENHI-PROJECT-20H03295
[Journal Article] Transcranial cortex-wide fluorescence imaging through a fully intact skull, as a powerful tool for functional mapping: less invasive macroscopic imaging of cortical Ca2+ dynamics2020
- Author(s)
  Monai Hiromu
- Journal Title
  
  Natural Science Report, Ochanomizu University
  
  Volume: 71 Pages: 39-50
- NAID
  120006895205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15895
[Journal Article] An Example of R&D with RIKEN CBS-OLYMPUS Collaboration Center (BOCC)2020
- Author(s)
  Monai Hiromu、Ue Yoshihiro、Miyawaki Atsushi
- Journal Title
  
  The Brain & Neural Networks
  
  Volume: 27 Issue: 1 Pages: 20-27
- DOI
  10.3902/jnns.27.20
- NAID
  130007840305
- ISSN
  1340-766X, 1883-0455
- Year and Date
  2020-03-05
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K14859
[Journal Article] 神経回路学会における「在野研究者」「企業研究者」の取り組み2020
- Author(s)
  毛内拡
- Journal Title
  
  The Brain & Neural Networks
  
  Volume: 27 Issue: 1 Pages: 1-3
- DOI
  10.3902/jnns.27.1
- NAID
  130007840299
- ISSN
  1340-766X, 1883-0455
- Year and Date
  2020-03-05
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K14859
[Journal Article] 編集後記2020
- Author(s)
  毛内拡
- Journal Title
  
  The Brain & Neural Networks
  
  Volume: 27 Issue: 1 Pages: 32-32
- DOI
  10.3902/jnns.27.32
- NAID
  130007840293
- ISSN
  1340-766X, 1883-0455
- Year and Date
  2020-03-05
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K14859
[Journal Article] Transcranial Direct Current Stimulation (tDCS) Induces Adrenergic Receptor-Dependent Microglial Morphological Changes in Mice2019
- Author(s)
  Mishima Tsuneko、Nagai Terumi、Yahagi Kazuko、Akther Sonam、Oe Yuki、Monai Hiromu、Kohsaka Shinichi、Hirase Hajime
- Journal Title
  
  eneuro
  
  Volume: 6 Issue: 5 Pages: 0214-0214
- DOI
  10.1523/eneuro.0204-19.2019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05150, KAKENHI-PROJECT-16H01888, KAKENHI-PROJECT-18K14859
[Journal Article] Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke2019
- Author(s)
  Monai Hiromu、Wang Xiaowen、Yahagi Kazuko、Lou Nanhong、Mestre Humberto、Xu Qiwu、Abe Yoichiro、Yasui Masato、Iwai Youichi、Nedergaard Maiken、Hirase Hajime
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 116 Issue: 22 Pages: 11010-11019
- DOI
  10.1073/pnas.1817347116
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H05150, KAKENHI-PROJECT-16H01888, KAKENHI-PROJECT-18H02606, KAKENHI-PROJECT-18K14859
[Journal Article] A spherical aberration-free microscopy system for live brain imaging2018
- Author(s)
  Ue Yoshihiro、Monai Hiromu、Higuchi Kaori、Nishiwaki Daisuke、Tajima Tetsuya、Okazaki Kenya、Hama Hiroshi、Hirase Hajime、Miyawaki Atsushi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 500 Issue: 2 Pages: 236-241
- DOI
  10.1016/j.bbrc.2018.04.049
- NAID
  40021394427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H01888, KAKENHI-PROJECT-16K13116, KAKENHI-PROJECT-18K14859, KAKENHI-PLANNED-15H05948
[Journal Article] Aquaporin-4-dependent glymphatic solute transport in the rodent brain2018
- Author(s)
  H. Mestre*, LM. Hablitz*, ALB. Xavier*, W. Feng*, W. Zou*, T. Pu*, H. Monai*, G. Murlidharan*, RM. Castellanos Rivera*, MJ. Simon*, MM. Pike*, V. Pla*, T. Du*, BT. Kress*, X. Wang, BA. Plog, AS. Thrane, I. Lundgaard, Y. Abe, M. Yasui, JH. Thomas, M. Xiao, H. Hirase, A. Asokan, JJ. Iliff, M. Nedergaard
- Journal Title
  
  eLife
  
  Volume: 7
- DOI
  10.7554/elife.40070
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859, KAKENHI-PUBLICLY-18H05150, KAKENHI-PROJECT-18H02606, KAKENHI-PROJECT-16H01888, KAKENHI-PROJECT-17K19637, KAKENHI-PROJECT-16H05134
[Presentation] Calcium imaging reveals the gut-brain axis via the vagus nerve involvement in the sucrose preference reduction after psychological stress in mice2023
- Author(s)
  山田芹華, 原田一貴, 坪井貴司, 毛内拡
- Organizer
  日本生理学会
- Data Source
  KAKENHI-PUBLICLY-21H05616
[Presentation] Microglial involvement in the dysregulation of aquaporin-4 after acute adrenergic receptor agonism.2022
- Author(s)
  森田笑子, 毛内拡
- Organizer
  第99回日本生理学会
- Data Source
  KAKENHI-PROJECT-20K15895
[Presentation] 腸内グルコース直接投与によって生じる大脳皮質ダイナミクスの経頭蓋カルシウムイメージング2022
- Author(s)
  山田芹華, 原田一貴, 坪井貴司, 毛内拡
- Organizer
  NEURO2022
- Data Source
  KAKENHI-PUBLICLY-21H05616
[Presentation] ヒト特異的な遺伝的変異を持つマウス作製と行動表現型の解析2022
- Author(s)
  森本梨々花, 中谷一真, 小林千紘, 末永雄介, 毛内拡
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PUBLICLY-21H05616
[Presentation] Transcranial direct current stimulation alters cerebrospinal fluid-interstitial fluid exchanges in mouse brain2021
- Author(s)
  Yan Wang, Hiromu Monai
- Organizer
  12th Ewha-JWU-Ochanomizu Joint Symposium 2021
- Data Source
  KAKENHI-PROJECT-20K15895
[Presentation] 健康な脳機能を支える脳内ロジスティクス2020
- Author(s)
  毛内拡
- Organizer
  第63回日本神経化学会大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15895
[Presentation] 覚醒マウスにおける経頭蓋マクロイメージング法の確立2020
- Author(s)
  武井理乃, 毛内拡
- Organizer
  第９回日本生物物理学会関東支部会
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 球面収差自動補正システムによる脳組織の in vivo 水組成推定2020
- Author(s)
  郷間葵, 足立尚哉, 上喜裕, 樋口香織, 宮脇敦史, 毛内拡
- Organizer
  第９回日本生物物理学会関東支部会
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 脳損傷に伴う異常なCa2+波の伝播と回復の可視化2020
- Author(s)
  毛内拡, 平瀬肇
- Organizer
  第29回日本バイオイメージング学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15895
[Presentation] Brain water channel AQP4 involvement in normalization of extracellular potassium after acute ischemic stroke2020
- Author(s)
  毛内拡
- Organizer
  ドイツ・ボン大学
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] AQP4 involvement in normalization of extracellular potassium after acute ischemic stroke2019
- Author(s)
  H. Monai, X. Wang, K. Yahagi, N. Lou, H. Mestre, Q. Xu, Y. Abe, M. Yasui, Y. Iwai, M. Nedergaard, H. Hirase
- Organizer
  第9回アジア・オセアニア生理学会連合大会 FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 健康な脳のカギを握る脳の中のメタコミュニケーション2019
- Author(s)
  毛内拡
- Organizer
  北海道大学電子科学研究所ニコンイメージングセンター
- Invited
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 生体深部の球面収差を補正し、鮮明に観察するための顕微鏡システム2019
- Author(s)
  毛内拡
- Organizer
  第７回生物計測応用研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 健康な脳のカギを握る脳の中のメタコミュニケーション2019
- Author(s)
  毛内拡
- Organizer
  第42回日本神経科学大会・第62回神経化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 健康な脳のカギを握る脳の中のメタコミュニケーション2019
- Author(s)
  毛内拡
- Organizer
  第6回サイコグリア研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] Astrocytes, keeping the brain healthy, not just supporting cells for neurons2019
- Author(s)
  Aoi Gohma, Risa Tsurukame, Ayumi Takamizawa, Shoko Nakasono, Saya Katagiri, Hiromu Monai
- Organizer
  10th Ewha-JWU-Ochanomizu Joint Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] AQP4 involvement in normalization of extracellular potassium after acute ischemic stroke2019
- Author(s)
  H. Monai, X. Wang, K. Yahagi, N. Lou, H. Mestre, Q. Xu, Y. Abe, M. Yasui, Y. Iwai, M. Nedergaard, H. Hirase
- Organizer
  Young Glia/ SPP1757
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 健康な脳のはたらきを守り、支えるアストロサイト2019
- Author(s)
  毛内拡
- Organizer
  寧夏回族自治区青年科学技術者交流団との学術交流会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] rain water channel aquaporin-4 involvement in tissue injury after photothrombotic stroke in mice2019
- Author(s)
  Saya Katagiri, Hiromu Monai
- Organizer
  10th Ewha-JWU-Ochanomizu Joint Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 健康な脳のはたらきを守り、支えるアストロサイト2019
- Author(s)
  毛内拡
- Organizer
  JSTグローバルサイエンスキャンパス事業「医学・医療の学際的修学、半学半教」
- Invited
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 健康な脳のカギを握る脳の中のメタコミュニケーション2019
- Author(s)
  毛内拡
- Organizer
  第二回形態解析ワークショップ ―多様な顕微鏡を用いて
- Invited
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 健康な脳の鍵を握る脳の中のメタコミュニケーション2019
- Author(s)
  毛内拡
- Organizer
  国立研究開発法人量子科学技術研究開発機構放射線医学総合研究所脳機能イメージング研究部セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke2019
- Author(s)
  H. Monai, X. Wang, K. Yahagi, N. Lou, H. Mestre, Q. Xu, Y. Abe, M. Yasui, Y. Iwai, M. Nedergaard, H. Hirase
- Organizer
  第9回アジア・オセアニア生理学会連合大会 FAOPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 健康な脳のはたらきを守り、支えるアストロサイト2019
- Author(s)
  毛内拡
- Organizer
  国立研究開発法人量子科学技術研究開発機構放射線医学総合研究所脳機能イメージング研究部
- Invited
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] Visualization of cortex-wide brain activity in living mouse2019
- Author(s)
  Rino Takei, Ayaka Kurihara, Hitomi Achiwa, Nanami Tsuji, Saya Katagiri, Hiromu Monai
- Organizer
  10th Ewha-JWU-Ochanomizu Joint Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] Glial involvement in transcranial direct current stimulation (tDCS)-induced plasticity2019
- Author(s)
  毛内拡
- Organizer
  第2回「エクスプロラシオン・フランス」プログラム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 脳の中のメタコミュニケーション～ニューロン以外の要素が知性をつくる！？～2018
- Author(s)
  毛内拡
- Organizer
  東京薬科大学生命科学部創立25周年記念シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] Macroscopic neuroglial imaging of pathological states using a G-CaMP Tg mouse2018
- Author(s)
  H. Monai and H. Hirase
- Organizer
  研究拠点形成事業 Young Glia/ SPP1757
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke2018
- Author(s)
  H. Monai, X. Wang, K. Yahagi, N. Lou, H. Mestre, Q. Xu, Y. Abe, M. Yasui, Y. Iwai, M. Nedergaard, H. Hirase
- Organizer
  Society for Neuroscience Annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 深部微細構造を鮮明かつ定量的にイメージングする自動球面収差補正システム2018
- Author(s)
  上喜裕, 毛内拡, 樋口香織, 西脇大介, 田島鉄也, 岡咲賢哉, 濱裕, 平瀬肇, 宮脇敦史
- Organizer
  第27会日本バイオイメージング学会年次大会
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 脳虚血超急性期の細胞外カリウムイオン濃度正常化における水チャネル AQP4 の関与2018
- Author(s)
  H. Monai, X. Wang, K. Yahagi1, N. Lou, H. Mestre, Q. Xu, Y. Abe, M. Yasui, Y. Iwai, M. Nedergaard, H. Hirase
- Organizer
  第61回日本神経化学会大会・第40回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke2018
- Author(s)
  H. Monai, X. Wang, K. Yahagi, N. Lou, H. Mestre, Q. Xu, Y. Abe, M. Yasui, Y. Iwai, M. Nedergaard, H. Hirase
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K14859
[Presentation] 健康な脳を支え、守る、グリア細胞の働き2018
- Author(s)
  毛内拡
- Organizer
  第3回お茶の水女子大学ヒューマンライフイノベーション研究所公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K14859

1. GOTOH Mari (80467050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 宮本泰則 (50272737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 塚田啓道 (40794087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 池口徹 (30222863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 塚田稔 (80074392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 奈良重俊 (60231495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 篠原良章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 平瀬肇

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Monai Hiromu 毛内 拡

Research Projects

Research Products

Co-Researchers

Understanding Top-Down Mechanisms in the Dynamics of Contextual Memory and Learning

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アストロサイトにヒト特異的遺伝的変異を導入した遺伝子改変マウスの生理機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanisms of the dysregulation of brain water channel aquaporin 4 (AQP4) after acute ischemic stroke in mice brainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel mechanism of bioactive lipids with neuroprotective effects: application for treatment of cerebrovascular disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanisms of extracellular ion homeostasis by brain fluid dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 脳を司る「脳」 最新研究で見えてきた、驚くべき脳のはたらき2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 脳の半分を占める グリア細胞2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcranial cortex-wide fluorescence imaging through a fully intact skull, as a powerful tool for functional mapping: less invasive macroscopic imaging of cortical Ca2+ dynamics2020

Author(s)

Journal Title

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[Journal Article] An Example of R&amp;D with RIKEN CBS-OLYMPUS Collaboration Center (BOCC)2020

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[Journal Article] 神経回路学会における「在野研究者」「企業研究者」の取り組み2020

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[Journal Article] 編集後記2020

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Monai Hiromu 毛内拡

[Book] 脳を司る「脳」　最新研究で見えてきた、驚くべき脳のはたらき2020

[Book] 脳の半分を占める　グリア細胞2019

[Journal Article] An Example of R&D with RIKEN CBS-OLYMPUS Collaboration Center (BOCC)2020