ISHIHARA TOMOAKI 石原知明

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Ishihara Tomoaki 石原知明

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Researcher Number	90724013
Other IDs	https://orcid.org/0000-0002-0840-008X
Affiliation (Current)	2026: 長崎国際大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 長崎国際大学, 薬学部, 講師 2018: 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Genome biology Except Principal Investigator Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator オートファジー / 老化 / 脂質代謝 / 脂質 / ビスモノアシルグリセロリン酸 / 代謝異常 / 老化関連疾患 / 細胞老化 / 共生細菌叢 / 脂質代謝酵素 … More / 共生細菌 / 性差 / トランスクリプトーム / LC-MS/MS / リピドミクス / 薬理学 / 分析科学 / 生理活性 / 酵素 / シトクロムP450 / 機能性代謝物 / シトクロムP450（Cyp） / エイコサペンタエン酸 / 17,18-EpETE / EPA / 生体恒常性 / チトクロムP450 / 活性代謝物 / 脂肪酸代謝酵素 / ω3脂肪酸 … More Except Principal Investigator 活性酸素 / リン脂質 / サルコペニア / 糖尿病 / 筋萎縮 Less

糖尿病性筋萎縮とサルコペニアに共通するリン脂質過酸化の役割解明と治療法の開発
- Principal Investigator
  
  江島弘晃
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nagasaki International University
Elucidation of the Autophagy Regulatory Mechanism Mediated by Aging-Associated Bis(monoacylglycero)phosphate AccumulationPrincipal Investigator
- Principal Investigator
  
  石原知明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nagasaki International University
Elucidation of Age-Associated Dysregulation in Lipid Metabolism and Its Impact on Aging-Related PhenotypesPrincipal Investigator
- Principal Investigator
  
  Ishihara Tomoaki
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nagasaki International University
Comprehensive analysis of the metabolic pathway involved in the biological function of omega-3 fatty acidsPrincipal Investigator
- Principal Investigator
  
  Ishihara Tomoaki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  Institute of Physical and Chemical Research

All 2025 2024 2022 2019 2018 2017

All Journal Article Presentation

[Journal Article] Transcriptomic and lipidomic analysis of aging-associated inflammatory signature in mouse liver2025
- Author(s)
  Ishihara Tomoaki、Tsugawa Hiroshi、Iwanami Seigo、Chang Jen-Chien、Minoda Aki、Arita Makoto
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 45 Issue: 1
- DOI
  10.1186/s41232-025-00377-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K11718
[Journal Article] マウス加齢変容のノンターゲットリピドミクス2025
- Author(s)
  石原　知明、津川裕司、有田誠
- Journal Title
  
  炎症と免疫
  
  Volume: 32 Pages: 91-96
- Data Source
  KAKENHI-PROJECT-22K11718
[Journal Article] Deuterium-reinforced polyunsaturated fatty acids protect against muscle atrophy by STZ-induced diabetic mice2025
- Author(s)
  Eshima Hiroaki、Ishihara Tomoaki、Tabuchi Ayaka、Kano Yutaka、Kurokawa Kenji、Shchepinov Mikhail S.
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 230 Pages: 273-282
- DOI
  10.1016/j.freeradbiomed.2025.02.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K11718, KAKENHI-PROJECT-22K17745
[Journal Article] A lipidome landscape of aging in mice2024
- Author(s)
  Tsugawa Hiroshi、Ishihara Tomoaki、Ogasa Kota、Iwanami Seigo、Hori Aya、Takahashi Mikiko、Yamada Yutaka、Satoh-Takayama Naoko、Ohno Hiroshi、Minoda Aki、Arita Makoto
- Journal Title
  
  Nature Aging
  
  Volume: 0 Issue: 5 Pages: 1-18
- DOI
  10.1038/s43587-024-00610-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18216, KAKENHI-PROJECT-20KK0360, KAKENHI-PROJECT-22K11718
[Journal Article] Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis2022
- Author(s)
  Mio Yoshida, Tomoaki Ishihara, Yosuke Isobe, Makoto Arita
- Journal Title
  
  FASEB Journal
  
  Volume: 36(12) Issue: 12
- DOI
  10.1096/fj.202200982r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11718, KAKENHI-PROJECT-20H00495
[Journal Article] Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis2019
- Author(s)
  Ishihara Tomoaki、Yoshida Mio、Arita Makoto
- Journal Title
  
  International Immunology
  
  Volume: - Issue: 9 Pages: 559-567
- DOI
  10.1093/intimm/dxz001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05898, KAKENHI-PROJECT-17K18364, KAKENHI-ORGANIZER-15H05897
[Journal Article] ω３脂肪酸由来脂質メディエーターと炎症制御2018
- Author(s)
  吉田美桜、礒部洋輔、石原知明、有田誠
- Journal Title
  
  細胞
  
  Volume: 50 Pages: 8-12
- Data Source
  KAKENHI-PROJECT-17K18364
[Journal Article] Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid2018
- Author(s)
  Isobe Yosuke、Kawashima Yusuke、Ishihara Tomoaki、Watanabe Kenji、Ohara Osamu、Arita Makoto
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 13 Issue: 4 Pages: 887-893
- DOI
  10.1021/acschembio.7b01092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18360, KAKENHI-PROJECT-17K18364, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05898
[Journal Article] ω3脂肪酸の代謝と抗炎症作用2017
- Author(s)
  石原知明, 磯部洋輔, 有田誠
- Journal Title
  
  ビタミン
  
  Volume: 91 Pages: 537-541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K18364
[Presentation] A型ウエルシュ菌感染に対する宿主応答の解析2024
- Author(s)
  石原知明，阪口義彦，永浜政博，竹原正也
- Organizer
  第97回細菌学会
- Data Source
  KAKENHI-PROJECT-22K11718
[Presentation] Protective role of omega-3 fatty acid oxygenase in skin homeostasis2018
- Author(s)
  Tomoaki Ishihara
- Organizer
  The Annual Meeting of Aging Project 2018
- Data Source
  KAKENHI-PROJECT-17K18364
[Presentation] 皮膚の組織恒常性における脂肪酸代謝系の関与2017
- Author(s)
  石原　知明, 磯部　洋輔, 吉田　美桜, 板垣　舞, 有田　誠
- Organizer
  第42回日本医用マススペクトル学会年会
- Data Source
  KAKENHI-PROJECT-17K18364
[Presentation] Emerging roles of fatty acid metabolism in tissue homeostasis and aging2017
- Author(s)
  Tomoaki Ishihara
- Organizer
  Young researchers workshop Integrated life science research to challenge super aging society
- Data Source
  KAKENHI-PROJECT-17K18364

1. 江島弘晃 (80759259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 伊藤隼哉 (50781647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 黒川健児 (80304963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 仲川清隆 (80361145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Arita Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. Ikeda Kazutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 川島祐介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 有田正規

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 津川裕司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIHARA TOMOAKI 石原 知明

Ishihara Tomoaki 石原 知明

Research Projects

Research Products

Co-Researchers

糖尿病性筋萎縮とサルコペニアに共通するリン脂質過酸化の役割解明と治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Autophagy Regulatory Mechanism Mediated by Aging-Associated Bis(monoacylglycero)phosphate AccumulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Age-Associated Dysregulation in Lipid Metabolism and Its Impact on Aging-Related PhenotypesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of the metabolic pathway involved in the biological function of omega-3 fatty acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transcriptomic and lipidomic analysis of aging-associated inflammatory signature in mouse liver2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] マウス加齢変容のノンターゲットリピドミクス2025

Author(s)

Journal Title

Data Source

[Journal Article] Deuterium-reinforced polyunsaturated fatty acids protect against muscle atrophy by STZ-induced diabetic mice2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A lipidome landscape of aging in mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ω３脂肪酸由来脂質メディエーターと炎症制御2018

Author(s)

Journal Title

Data Source

[Journal Article] Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ω3脂肪酸の代謝と抗炎症作用2017

Author(s)

Journal Title

Data Source

[Presentation] A型ウエルシュ菌感染に対する宿主応答の解析2024

Author(s)

Organizer

Data Source

[Presentation] Protective role of omega-3 fatty acid oxygenase in skin homeostasis2018

Author(s)

Organizer

Data Source

[Presentation] 皮膚の組織恒常性における脂肪酸代謝系の関与2017

ISHIHARA TOMOAKI 石原知明

Ishihara Tomoaki 石原知明