Kasho Kazutoshi 加生和寿

… Alternative Names

KASHO Kazutoshi 加生和寿

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Researcher Number	90726019
Other IDs	https://orcid.org/0000-0003-0326-0740
Affiliation (Current)	2024: 九州大学, 薬学研究院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2022: 九州大学, 薬学研究院, 助教 2016 – 2017: 九州大学, 薬学研究院, 助教 2016: 九州大学, 大学院薬学研究院, 助教 2015: 九州大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 43010:Molecular biology-related / 0701:Biology at molecular to cellular levels, and related fields Except Principal Investigator Genetics/Chromosome dynamics
Keywords	Principal Investigator 試験管内再構成 / 複製 / mtDNA / ミトコンドリア / DNA複製 / 大規模欠損 / コピー数制御 / コピー数 / 複製開始 / 試験管内解析 … More / 炎症 / mtDNA複製 / NLRP3 / DARS2 / 大腸菌 / 染色体複製 / DnaA / 細胞周期 / IHF / 核様体蛋白質 … More Except Principal Investigator 生体生命情報学 / 細菌 / ゲノム / 遺伝子 / 遺伝学 Less

Biochemical study about the regulatory mechanism for mitochondrial genome replication and maintenancePrincipal Investigator
- Principal Investigator
  
  加生和寿
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Kyushu University
Analysis about mitochondrial genome signaling for activating NLRP3 inflammationPrincipal Investigator
- Principal Investigator
  
  Kasho Kazutoshi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyushu University
複製開始を制御する核様体因子IHFの適時的な結合-解離の制御機構の解析Principal Investigator
- Principal Investigator
  
  加生和寿
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kyushu University
Regulatory mechanism for timely DARS2 activationPrincipal Investigator
- Principal Investigator
  
  KASHO Kazutoshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kyushu University
Genomic and functional analysis for novel long-chain inverted repeats
- Principal Investigator
  
  Katayama Tsutomu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  Kyushu University

All 2022 2021 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Concerted actions of DnaA complexes with DNA-unwinding sequences within and flanking replication origin oriC promote DnaB helicase loading2022
- Author(s)
  Sakiyama Yukari、Nagata Mariko、Yoshida Ryusei、Kasho Kazutoshi、Ozaki Shogo、Katayama Tsutomu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 6 Pages: 102051-102051
- DOI
  10.1016/j.jbc.2022.102051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06087, KAKENHI-PROJECT-20H03212, KAKENHI-PROJECT-22KJ2423, KAKENHI-PROJECT-21K20640
[Journal Article] TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication2022
- Author(s)
  Inatomi Teppei、Matsuda Shigeru、Ishiuchi Takashi、Do Yura、Nakayama Masunari、Abe Shusaku、Kasho Kazutoshi、Wanrooij Sjoerd、Nakada Kazuto、Ichiyanagi Kenji、Sasaki Hiroyuki、Yasukawa Takehiro、Kang Dongchon
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1869 Issue: 1 Pages: 119167-119167
- DOI
  10.1016/j.bbamcr.2021.119167
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-19H05756, KAKENHI-PROJECT-21K07127, KAKENHI-PROJECT-21K20640, KAKENHI-PROJECT-20H00530
[Journal Article] Cooperative DnaA binding to the negatively supercoiled datA locus stimulates DnaA-ATP hydrolysis2017
- Author(s)
  Kazutoshi Kasho, Hiroyuki Tanaka, Ryuji Sakai, Tsutomu Katayama
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 4 Pages: 1251-1266
- DOI
  10.1074/jbc.m116.762815
- NAID
  120005971209
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H00775, KAKENHI-PROJECT-26291004, KAKENHI-PROJECT-15K18479
[Journal Article] Chromosomal location of the DnaA-reactivating sequence DARS2 is important to regulate timely initiation of DNA replication in Escherichia coli2016
- Author(s)
  Yukie Inoue, Hiroyuki Tanaka, Kazutoshi Kasho, Kazuyuki Fujimitsu, Taku Oshima, Tsutomu Katayama
- Journal Title
  
  Genes Cells
  
  Volume: 21 Issue: 9 Pages: 1015-1023
- DOI
  10.1111/gtc.12395
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H00775, KAKENHI-PROJECT-26291004, KAKENHI-PROJECT-26450090, KAKENHI-PROJECT-15K18479
[Presentation] 脊椎動物型ミトコンドリアゲノム複製開始の進化的起源に迫る2022
- Author(s)
  加生　和寿、片山　勉
- Organizer
  第45回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06087
[Presentation] 脊椎動物型ミトコンドリアゲノム複製開始の進化的起源に迫る2022
- Author(s)
  加生　和寿、片山　勉
- Organizer
  第45回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K20640
[Presentation] Regulation of replication initiation timing by timely binding and dissociation of the nucleoid protein IHF in Escherichia coli2022
- Author(s)
  Kazutoshi Kasho, Taku Oshima, Onuma Chumsakul, Kensuke Nakamura, Kazuki Fukamachi, Kazuyuki Fujimitsu, and Tsutomu Katayama
- Organizer
  遺伝研国際シンポジウム2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06087
[Presentation] Regulation of replication initiation timing by timely binding and dissociation of the nucleoid protein IHF in Escherichia coli2022
- Author(s)
  Kazutoshi Kasho, Taku Oshima, Onuma Chumsakul, Kensuke Nakamura, Kazuki Fukamachi, Kazuyuki Fujimitsu, and Tsutomu Katayam
- Organizer
  遺伝研国際シンポジウム2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20640
[Presentation] ユニークな多機能蛋白質PolDIP2によるPrimPol依存的ミトコンドリアゲノム維持の新規制御機構2021
- Author(s)
  加生　和寿, Anais Lamy, Andreas Berner, Tran Nguyen, Gorazd Stojkovic, Cristina Velazquez-Ruiz, Maria Isabel Martinez-Jimenez, Mara Doimo, Timothee Laurent, Aldo E. Perez-Rivera, Ronnie Berntsson, Luis Blanco, and Sjoerd Wanrooij
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K20640
[Presentation] 大腸菌の核様体蛋白質IHFはゲノム複製開始時期において複製開始点oriCとの結合が特異的に安定化される2021
- Author(s)
  加生　和寿、大島　拓、Onuma Chumsakul、中村　健介、深町　和貴、片山　勉
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K20640
[Presentation] PrimPol-PolDIP2 複合体によるミトコンドリアゲノム維持の分子機構2021
- Author(s)
  加生和寿, Gorazd Stojkovic, Mara Doimo, Berner Andreas, Cristina Velazquez-Ruiz, Maria I. Martinez-Jimenez, Timothee Laurent, Aldo E. Perez-Rivera, Luis Blanco, Sjoerd Wanrooij
- Organizer
  第26回 DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-21K20640
[Presentation] Genetic analyses of a unique, long intergenic region in E. coli2017
- Author(s)
  呉唯意, 土田愛海, 川上広宣, 加生和寿, 片山勉
- Organizer
  KAIST-Kyushu University Joint Seminar
- Place of Presentation
  休暇村志賀島（福岡県福岡市）
- Year and Date
  2017-01-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26650127
[Presentation] 大腸菌染色体datA配列による複製開始蛋白質DnaA不活性化機構のDNA超らせんに応じた制御の解析2016
- Author(s)
  加生　和寿、田中　宏幸、酒井　隆至、片山　勉
- Organizer
  平成２８年度日本生化学会九州支部例会
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
- Year and Date
  2016-05-14
- Data Source
  KAKENHI-PROJECT-15K18479
[Presentation] 細胞増殖に必須な長鎖逆方向反復配列の役割と保存性の推定2016
- Author(s)
  川上広宣, 土田愛海, 竹原通秋, 加生和寿, 片山勉
- Organizer
  第13回21世紀大腸菌研究会
- Place of Presentation
  グリーンピア南阿蘇（熊本県阿蘇郡）
- Year and Date
  2016-06-02
- Data Source
  KAKENHI-PROJECT-26650127
[Presentation] Regulation of timely replication initiation by a nucleoid protein IHF on DnaA activating and inactivating DNA elements, DARS2 and datA in Escherichia coli.2016
- Author(s)
  Kasho, K., Inoue, Y., Oshima, T., Fujimitsu, K., and Katayama, T.
- Organizer
  10th 3R symposium
- Place of Presentation
  ホテル一畑（島根県松江市）
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18479
[Presentation] 核様体蛋白質IHFと特異的なDNA部位との複合体形成・解離による複製開始タイミング制御2016
- Author(s)
  加生　和寿、大島　拓、片山　勉
- Organizer
  日本遺伝学会第88回大会
- Place of Presentation
  日本大学国際関係学部三島駅北口校舎（静岡県三島市）
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-15K18479
[Presentation] 大腸菌染色体datA領域による複製開始蛋白質DnaAの不活性化機構は DNA超らせん構造依存的に制御される2015
- Author(s)
  加生和寿、田中宏幸、片山勉
- Organizer
  第３８回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18479
[Presentation] 大腸菌の複製起点における複製開始複合体の形成と複製タイミング調節因子の集合の動的な制御2015
- Author(s)
  加生　和寿、村谷　周悟、毛谷村　賢司、片山　勉
- Organizer
  第２３回 DNA 複製・組換え・修復ワークショップ
- Place of Presentation
  焼津グランドホテル（静岡県焼津市）
- Year and Date
  2015-10-19
- Data Source
  KAKENHI-PROJECT-15K18479
[Presentation] 大腸菌染色体上のdatA 領域によるDnaA 不活性化の新たな制御；DNA 超らせん構造による促進2015
- Author(s)
  加生和寿、田中宏幸、片山勉
- Organizer
  第15回薬学研究院若手セミナー
- Place of Presentation
  九州大学医系地区コラボステーションII（福岡県福岡市）
- Year and Date
  2015-09-08
- Data Source
  KAKENHI-PROJECT-15K18479
[Presentation] 大腸菌の増殖に必須な長鎖逆方向反復配列ELIXIR1の機能解析
- Author(s)
  土田愛海, 川上広宣, 加生和寿, 末次正幸, 片山勉
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26650127

1. Katayama Tsutomu (70264059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. KAWAKAMI Hironori (50403952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. MAYANAGI Kota

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 石内崇士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kasho Kazutoshi 加生 和寿

KASHO Kazutoshi 加生 和寿

Research Projects

Research Products

Co-Researchers

Biochemical study about the regulatory mechanism for mitochondrial genome replication and maintenancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis about mitochondrial genome signaling for activating NLRP3 inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

複製開始を制御する核様体因子IHFの適時的な結合-解離の制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanism for timely DARS2 activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genomic and functional analysis for novel long-chain inverted repeats

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Concerted actions of DnaA complexes with DNA-unwinding sequences within and flanking replication origin oriC promote DnaB helicase loading2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cooperative DnaA binding to the negatively supercoiled datA locus stimulates DnaA-ATP hydrolysis2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Chromosomal location of the DnaA-reactivating sequence DARS2 is important to regulate timely initiation of DNA replication in Escherichia coli2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 脊椎動物型ミトコンドリアゲノム複製開始の進化的起源に迫る2022

Author(s)

Organizer

Data Source

[Presentation] 脊椎動物型ミトコンドリアゲノム複製開始の進化的起源に迫る2022

Author(s)

Organizer

Data Source

[Presentation] Regulation of replication initiation timing by timely binding and dissociation of the nucleoid protein IHF in Escherichia coli2022

Author(s)

Organizer

Data Source

[Presentation] Regulation of replication initiation timing by timely binding and dissociation of the nucleoid protein IHF in Escherichia coli2022

Author(s)

Organizer

Data Source

[Presentation] ユニークな多機能蛋白質PolDIP2によるPrimPol依存的ミトコンドリアゲノム維持の新規制御機構2021

Author(s)

Organizer

Data Source

[Presentation] 大腸菌の核様体蛋白質IHFはゲノム複製開始時期において複製開始点oriCとの結合が特異的に安定化される2021

Author(s)

Organizer

Data Source

Kasho Kazutoshi 加生和寿

KASHO Kazutoshi 加生和寿