KAWAHARA KENTA 川原健太

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Kawahara Kenta 川原健太

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Researcher Number	90732735
Other IDs
Affiliation (Current)	2025: 熊本大学, 病院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 熊本大学, 病院, 助教 2019 – 2020: 熊本大学, 病院, 病院教員 2017 – 2018: 熊本大学, 医学部附属病院, 病院教員 2016: 熊本大学, 医学部附属病院, 医員 2015: 熊本大学, 医学部附属病院, その他
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords	Principal Investigator 口腔癌 / オルガネラ / カルシウム / ミトコンドリア / シスプラチン耐性 / 抗癌剤耐性 / ストア依存性カルシウムチャネル / カルシウムキレーター / 抗腫瘍免疫 / 所属リンパ節 … More / M1マクロファージ / 癌免疫 / CD8 / CD169 / リンパ節マクロファージ / 腫瘍免疫 / miR-30a / Drosha / Dicer / OSCC / exosomal miRNA / exosomal microRNA / microRNA Less

Are calcium and mitochondrial morphology regulation involved in treatment resistance in oral cancer?Principal Investigator
- Principal Investigator
  
  川原健太
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Elucidation of the mechanism of mitochondorial dynamics for chemoresistance and creation of novel therapeutic methodsPrincipal Investigator
- Principal Investigator
  
  Kawahara Kenta
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Relationship between antitumor immunity and lymph node immune environment in oral canerPrincipal Investigator
- Principal Investigator
  
  Kawahara Kenta
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kumamoto University
Investigation of the mechanisms underlying chemoresistance through microRNA modulation and applications to individualized therapy in oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Kawahara Kenta
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kumamoto University

All 2024 2023 2022 2021 2019 2016 2015

All Journal Article Presentation

[Journal Article] FOXM1-Mediated Regulation of Reactive Oxygen Species and Radioresistance in Oral Squamous Cell Carcinoma Cells2023
- Author(s)
  Takeshita Hisashi、Yoshida Ryoji、Inoue Junki、Ishikawa Kohei、Shinohara K、Hirayama M、Oyama T、Kubo R、Yamana K、Nagao Y、Gohara S、Sakata J、Nakashima H、Matsuoka Y、Nakamoto M、Hirayama M、Kawahara K、Takahashi N、Hirosue A、Kuwahara Y、Fukumoto M、Toya R、Murakami R、Nakayama H
- Journal Title
  
  Laboratory Investigation
  
  Volume: 103 Issue: 5 Pages: 100060-100060
- DOI
  10.1016/j.labinv.2022.100060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K12173, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-22K12379, KAKENHI-PROJECT-21K17145, KAKENHI-PROJECT-23K09400, KAKENHI-PROJECT-21K10099
[Journal Article] Programmed death-ligand 1-expressing extracellular vesicles are a prognostic factor in patients with oral squamous cell carcinoma treated with immune checkpoint inhibitors2023
- Author(s)
  Seki Yuki、Yamana Keisuke、Yoshida Ryoji、Inoue Junki、Shinohara Kosuke、Oyama Toru、Kubo Ryuta、Nagata Masashi、Kawahara Kenta、Hirayama Masatoshi、Takahashi Nozomu、Nakamoto Masafumi、Hirosue Akiyuki、Kariya Ryusho、Okada Seiji、Nakayama Hideki
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
  
  Volume: in press Issue: 4 Pages: 518-525
- DOI
  10.1016/j.ajoms.2023.12.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09400, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-21K10142
[Journal Article] Air Plasma-Activated Medium Evokes a Death-Associated Perinuclear Mitochondrial Clustering2022
- Author(s)
  Manami Suzuki-Karasaki, Takashi Ando, Yushi Ochiai, Kenta Kawahara, Miki Suzuki-Karasaki, Hideki Nakayama, Yoshihiro Suzuki-Karasaki.
- Journal Title
  
  International Journal of Molecular Science
  
  Volume: 23 Issue: 3 Pages: 1124-1124
- DOI
  10.3390/ijms23031124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09217, KAKENHI-PROJECT-21K10128, KAKENHI-PROJECT-20K17944, KAKENHI-PROJECT-20K18699
[Journal Article] Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration2022
- Author(s)
  Kawaguchi S、Kawahara a、Fujiwara Y、Ohnishi K、Pan C、Yano H、Hirosue A、Nagata M、Hirayama M、Sakata J、Nakashima H、Arita H、Yamana K、Gohara S、Nagao Y、Maeshiro M、Iwamoto A、Hirayama M、Yoshida R、Komohara Y、Nakayama H
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: - Issue: 9 Pages: 2127-2139
- DOI
  10.1007/s00262-022-03149-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07370, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-20K18699
[Journal Article] miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma.2021
- Author(s)
  Kenta Kawahara, Masashi Nagata, Ryoji Yoshida, Akiyuki Hirosue, Takuya Tanaka, Yuichiro Matsuoka, Hidetaka Arita, Hikaru Nakashima, Junki Sakata, Keisuke Yamana, Sho Kawaguchi, Shunsuke Gohara, Yuka Nagao, Masatoshi Hirayama, Nozomu Takahashi, Mayumi Hirayama, Hideki Nakayama
- Journal Title
  
  Biochemistry Biophysics Reports
  
  Volume: 21 Pages: 28-28
- DOI
  10.1016/j.bbrep.2021.101114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-20K18699, KAKENHI-PROJECT-21K17145
[Journal Article] Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study.2016
- Author(s)
  Nakashima H, Matsuoka Y, Yoshida R, Nagata M, Hirosue A, Kawahara K, Sakata J, Arita H, Hiraki A, Nakayama H.
- Journal Title
  
  BMC Cancer
  
  Volume: 16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20546
[Presentation] 口腔癌におけるミトコンドリア・カルシウムダイナミクスが及ぼす抗癌剤耐性機構の解明2024
- Author(s)
  川原　健太
- Organizer
  第6回治療耐性がん細胞研究協議会セミナー
- Data Source
  KAKENHI-PROJECT-23K09400
[Presentation] Calcium dynamics and mitochondrial morphology in oral cancer as a mechanism of cisplatin resistance2023
- Author(s)
  篠原　光佑、川原　健太
- Organizer
  第68回（公社）日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-23K09400
[Presentation] 治療抵抗性口腔癌とCa2+ダイナミクスの関連2023
- Author(s)
  篠原　光佑、川原　健太
- Organizer
  第47回日本頭頸部癌学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-23K09400
[Presentation] Calcium dynamics and mitochondrial morphology in oral cancer as a mechanism of cisplatin resistance2023
- Author(s)
  篠原　光佑、川原　健太
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K09400
[Presentation] Overexpression of miR-30a confers 5-FU resistance by inhibiting cell proliferation through targeting cyclin E2 in oral cancer.2019
- Author(s)
  Kenta Kawahara
- Organizer
  23rd International Symposium on Molecular Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11878
[Presentation] 口腔癌の化学放射線治療と唾液の変化に関する検討2016
- Author(s)
  川原　健太
- Organizer
  第34回　日本口腔腫瘍学会
- Place of Presentation
  横浜開港記念会館
- Year and Date
  2016-01-21
- Data Source
  KAKENHI-PROJECT-15K20546
[Presentation] 肺転移巣に対するCetuximab併用化学療法が奏効した唾液腺導管癌の1例2016
- Author(s)
  川原健太
- Organizer
  日本頭頸部癌学会学術総会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K20546
[Presentation] 転移性口腔扁平上皮癌細胞の放射線耐性について2015
- Author(s)
  川原　健太
- Organizer
  第39回　頭頸部癌学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-06-04
- Data Source
  KAKENHI-PROJECT-15K20546

1. 吉田遼司 (10632458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 菰原義弘 (40449921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中山秀樹 (70381001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SUZUKI Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 福本学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 大野剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 大西紘二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高橋望

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWAHARA KENTA 川原 健太

Kawahara Kenta 川原 健太

Research Projects

Research Products

Co-Researchers

Are calcium and mitochondrial morphology regulation involved in treatment resistance in oral cancer?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of mitochondorial dynamics for chemoresistance and creation of novel therapeutic methodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Relationship between antitumor immunity and lymph node immune environment in oral canerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanisms underlying chemoresistance through microRNA modulation and applications to individualized therapy in oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] FOXM1-Mediated Regulation of Reactive Oxygen Species and Radioresistance in Oral Squamous Cell Carcinoma Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Programmed death-ligand 1-expressing extracellular vesicles are a prognostic factor in patients with oral squamous cell carcinoma treated with immune checkpoint inhibitors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Air Plasma-Activated Medium Evokes a Death-Associated Perinuclear Mitochondrial Clustering2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study.2016

Author(s)

Journal Title

Data Source

[Presentation] 口腔癌におけるミトコンドリア・カルシウムダイナミクスが及ぼす抗癌剤耐性機構の解明2024

Author(s)

Organizer

Data Source

[Presentation] Calcium dynamics and mitochondrial morphology in oral cancer as a mechanism of cisplatin resistance2023

Author(s)

Organizer

Data Source

[Presentation] 治療抵抗性口腔癌とCa2+ダイナミクスの関連2023

Author(s)

Organizer

Data Source

[Presentation] Calcium dynamics and mitochondrial morphology in oral cancer as a mechanism of cisplatin resistance2023

Author(s)

Organizer

Data Source

[Presentation] Overexpression of miR-30a confers 5-FU resistance by inhibiting cell proliferation through targeting cyclin E2 in oral cancer.2019

Author(s)

Organizer

Data Source

[Presentation] 口腔癌の化学放射線治療と唾液の変化に関する検討2016

Author(s)

KAWAHARA KENTA 川原健太

Kawahara Kenta 川原健太