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KAWAHARA KENTA  川原 健太

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Kawahara Kenta  川原 健太

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Researcher Number 90732735
Other IDs
Affiliation (Current) 2025: 熊本大学, 病院, 助教
Affiliation (based on the past Project Information) *help 2021 – 2023: 熊本大学, 病院, 助教
2019 – 2020: 熊本大学, 病院, 病院教員
2017 – 2018: 熊本大学, 医学部附属病院, 病院教員
2016: 熊本大学, 医学部附属病院, 医員
2015: 熊本大学, 医学部附属病院, その他
Review Section/Research Field
Principal Investigator
Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords
Principal Investigator
口腔癌 / オルガネラ / カルシウム / ミトコンドリア / シスプラチン耐性 / 抗癌剤耐性 / ストア依存性カルシウムチャネル / カルシウムキレーター / 抗腫瘍免疫 / 所属リンパ節 … More / M1マクロファージ / 癌免疫 / CD8 / CD169 / リンパ節マクロファージ / 腫瘍免疫 / miR-30a / Drosha / Dicer / OSCC / exosomal miRNA / exosomal microRNA / microRNA Less
  • Research Projects

    (4 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (8 People)
  •  Are calcium and mitochondrial morphology regulation involved in treatment resistance in oral cancer?Principal Investigator

    • Principal Investigator
      川原 健太
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kumamoto University
  •  Elucidation of the mechanism of mitochondorial dynamics for chemoresistance and creation of novel therapeutic methodsPrincipal Investigator

    • Principal Investigator
      Kawahara Kenta
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kumamoto University
  •  Relationship between antitumor immunity and lymph node immune environment in oral canerPrincipal Investigator

    • Principal Investigator
      Kawahara Kenta
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kumamoto University
  •  Investigation of the mechanisms underlying chemoresistance through microRNA modulation and applications to individualized therapy in oral squamous cell carcinomaPrincipal Investigator

    • Principal Investigator
      Kawahara Kenta
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kumamoto University

All 2024 2023 2022 2021 2019 2016 2015

All Journal Article Presentation

  • [Journal Article] FOXM1-Mediated Regulation of Reactive Oxygen Species and Radioresistance in Oral Squamous Cell Carcinoma Cells2023

    • Author(s)
      Takeshita Hisashi、Yoshida Ryoji、Inoue Junki、Ishikawa Kohei、Shinohara K、Hirayama M、Oyama T、Kubo R、Yamana K、Nagao Y、Gohara S、Sakata J、Nakashima H、Matsuoka Y、Nakamoto M、Hirayama M、Kawahara K、Takahashi N、Hirosue A、Kuwahara Y、Fukumoto M、Toya R、Murakami R、Nakayama H
    • Journal Title

      Laboratory Investigation

      Volume: 103 Issue: 5 Pages: 100060-100060

    • DOI

      10.1016/j.labinv.2022.100060

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K12173, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-22K12379, KAKENHI-PROJECT-21K17145, KAKENHI-PROJECT-23K09400, KAKENHI-PROJECT-21K10099
  • [Journal Article] Programmed death-ligand 1-expressing extracellular vesicles are a prognostic factor in patients with oral squamous cell carcinoma treated with immune checkpoint inhibitors2023

    • Author(s)
      Seki Yuki、Yamana Keisuke、Yoshida Ryoji、Inoue Junki、Shinohara Kosuke、Oyama Toru、Kubo Ryuta、Nagata Masashi、Kawahara Kenta、Hirayama Masatoshi、Takahashi Nozomu、Nakamoto Masafumi、Hirosue Akiyuki、Kariya Ryusho、Okada Seiji、Nakayama Hideki
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: in press Issue: 4 Pages: 518-525

    • DOI

      10.1016/j.ajoms.2023.12.007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K09400, KAKENHI-PROJECT-21K10048, KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-21K10142
  • [Journal Article] Air Plasma-Activated Medium Evokes a Death-Associated Perinuclear Mitochondrial Clustering2022

    • Author(s)
      Manami Suzuki-Karasaki, Takashi Ando, Yushi Ochiai, Kenta Kawahara, Miki Suzuki-Karasaki, Hideki Nakayama, Yoshihiro Suzuki-Karasaki.
    • Journal Title

      International Journal of Molecular Science

      Volume: 23 Issue: 3 Pages: 1124-1124

    • DOI

      10.3390/ijms23031124

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09217, KAKENHI-PROJECT-21K10128, KAKENHI-PROJECT-20K17944, KAKENHI-PROJECT-20K18699
  • [Journal Article] Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration2022

    • Author(s)
      Kawaguchi S、Kawahara a、Fujiwara Y、Ohnishi K、Pan C、Yano H、Hirosue A、Nagata M、Hirayama M、Sakata J、Nakashima H、Arita H、Yamana K、Gohara S、Nagao Y、Maeshiro M、Iwamoto A、Hirayama M、Yoshida R、Komohara Y、Nakayama H
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: - Issue: 9 Pages: 2127-2139

    • DOI

      10.1007/s00262-022-03149-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07370, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-20K18699
  • [Journal Article] miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma.2021

    • Author(s)
      Kenta Kawahara, Masashi Nagata, Ryoji Yoshida, Akiyuki Hirosue, Takuya Tanaka, Yuichiro Matsuoka, Hidetaka Arita, Hikaru Nakashima, Junki Sakata, Keisuke Yamana, Sho Kawaguchi, Shunsuke Gohara, Yuka Nagao, Masatoshi Hirayama, Nozomu Takahashi, Mayumi Hirayama, Hideki Nakayama
    • Journal Title

      Biochemistry Biophysics Reports

      Volume: 21 Pages: 28-28

    • DOI

      10.1016/j.bbrep.2021.101114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K10099, KAKENHI-PROJECT-21K10118, KAKENHI-PROJECT-20K18699, KAKENHI-PROJECT-21K17145
  • [Journal Article] Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study.2016

    • Author(s)
      Nakashima H, Matsuoka Y, Yoshida R, Nagata M, Hirosue A, Kawahara K, Sakata J, Arita H, Hiraki A, Nakayama H.
    • Journal Title

      BMC Cancer

      Volume: 16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K20546
  • [Presentation] 口腔癌におけるミトコンドリア・カルシウムダイナミクスが及ぼす抗癌剤耐性機構の解明2024

    • Author(s)
      川原 健太
    • Organizer
      第6回 治療耐性がん細胞研究協議会セミナー
    • Data Source
      KAKENHI-PROJECT-23K09400
  • [Presentation] Calcium dynamics and mitochondrial morphology in oral cancer as a mechanism of cisplatin resistance2023

    • Author(s)
      篠原 光佑、川原 健太
    • Organizer
      第68回(公社)日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-23K09400
  • [Presentation] 治療抵抗性口腔癌とCa2+ダイナミクスの関連2023

    • Author(s)
      篠原 光佑、川原 健太
    • Organizer
      第47回 日本頭頸部癌学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-23K09400
  • [Presentation] Calcium dynamics and mitochondrial morphology in oral cancer as a mechanism of cisplatin resistance2023

    • Author(s)
      篠原 光佑、川原 健太
    • Organizer
      第82回 日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-23K09400
  • [Presentation] Overexpression of miR-30a confers 5-FU resistance by inhibiting cell proliferation through targeting cyclin E2 in oral cancer.2019

    • Author(s)
      Kenta Kawahara
    • Organizer
      23rd International Symposium on Molecular Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11878
  • [Presentation] 口腔癌の化学放射線治療と唾液の変化に関する検討2016

    • Author(s)
      川原 健太
    • Organizer
      第34回 日本口腔腫瘍学会
    • Place of Presentation
      横浜開港記念会館
    • Year and Date
      2016-01-21
    • Data Source
      KAKENHI-PROJECT-15K20546
  • [Presentation] 肺転移巣に対するCetuximab併用化学療法が奏効した唾液腺導管癌の1例2016

    • Author(s)
      川原健太
    • Organizer
      日本頭頸部癌学会学術総会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2016-06-09
    • Data Source
      KAKENHI-PROJECT-15K20546
  • [Presentation] 転移性口腔扁平上皮癌細胞の放射線耐性について2015

    • Author(s)
      川原 健太
    • Organizer
      第39回 頭頸部癌学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-06-04
    • Data Source
      KAKENHI-PROJECT-15K20546
  • 1.  吉田 遼司 (10632458)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  菰原 義弘 (40449921)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  中山 秀樹 (70381001)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  SUZUKI Yoshihiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  福本 学
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  大野 剛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  大西 紘二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  高橋 望
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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